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1.
Dermatol Ther ; : e15152, 2021 Oct 05.
Artigo em Inglês | MEDLINE | ID: mdl-34609042

RESUMO

BACKGROUND AND OBJECTIVES: Nevus of Ota has been successfully treated by lasers. Currently, 1064 nm picosecond Nd:YAG lasers have become available for the treatment of pigmented disorders. However, there are few studies concerning the application of 1064 nm picosecond Nd:YAG laser in nevus of Ota. This study aimed to evaluate the efficacy and safety of a 1064 nm picosecond Nd:YAG laser for the treatment of nevus of Ota. STUDY DESIGN/MATERIALS AND METHODS: We conducted a retrospective analysis of Chinese patients with nevus of Ota who had been treated with a 1064 nm picosecond Nd:YAG laser. Those who had any other laser treatment during the period of picosecond laser treatment were excluded. Via a visual analog scale for percentage of pigmentary clearance in standard photographs, the treatment efficacy was assessed by three blinded physician evaluators. RESULTS: A total of 16 subjects were included in this retrospective study. The average age at the beginning of treatment was 16.87 years old (range of 4 months to 59 years), and all patients were of Fitzpatrick skin type IV. Total treatment ranged from 1 to 5 sessions. A 1064 nm picosecond Nd:YAG laser with a mean fluence of 1.8-4.3 J/cm2 was used at 3 to 12 month intervals. The mean efficacy score for all 16 patients was 2.56 after one session, and the mean efficacy score of 13 patients who completed two sessions and 9 patients who completed three sessions were 3.15 and 3.51, respectively. Post-inflammatory hyperpigmentation after treatment was only observed in 1 (1/16, 6.25%) patient. CONCLUSION: The 1064 nm picosecond Nd:YAG laser is an effective and safe approach for treating nevus of Ota. This article is protected by copyright. All rights reserved.

2.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi ; 38(10): 1002-1006, 2021 Oct 10.
Artigo em Chinês | MEDLINE | ID: mdl-34625942

RESUMO

OBJECTIVE: To analyze the correlation of methylation status of dachshund homolog 1 (DACH1) gene in tumor tissues with clinicopathological characteristics and prognosis of patients of esophageal cancer. METHODS: Tumor tissue, paracancerous tissue and normal esophageal mucosal specimens of 104 patients with esophageal cancer were collected. Methylation-specific PCR was used to determine the methylation status of the DACH1 gene. Univariate analysis and multivariate Logistic regression model were used to analyze the correlation between DACH1 methylation status and clinical pathological characteristics of the patients. Kaplan-Meier survival curve was used to analyze the relationship between DACH1 methylation status and prognostic survival of patients. RESULTS: The methylation rate of the DACH1 gene in esophageal cancer tumor tissue was 30.77% (32/104), which was higher than those in adjacent tissues (1.92%) and normal esophageal mucosa (0%) (P< 0.05). The methylation status of the DACH1gene in tumor tissues of patients did not correlate with the patient's age, gender, and pathological type (P> 0.05) but tumor differentiation, TNM staging, and lymph node metastasis(P< 0.05). The degree of tumor differentiation, TNM stage, and lymph node metastasis of patients are independent risk factors for the methylation status of the DACH1 gene. By March 2020, 89 of the 104 patients had died. Among them, the median survival foresophageal cancer patients with DACH1 gene methylation was 22 months, which was lower than 34 months of those without DACH1 methylation (P< 0.05). CONCLUSION: Methylation of the DACH1 gene may be involved in the occurrence and progress of esophageal cancer. The degree of tumor differentiation, TNM stage, and lymph node metastasis of patients are independent risk factors for the methylation status of the DACH1 gene. Patients with esophageal cancer but unmethylated DACH1 gene have a longer prognostic survival.


Assuntos
Neoplasias Esofágicas , Animais , Cães , Neoplasias Esofágicas/genética , Neoplasias Esofágicas/patologia , Proteínas do Olho/genética , Humanos , Metástase Linfática , Metilação , Estadiamento de Neoplasias , Prognóstico , Fatores de Transcrição
3.
J Pharm Biomed Anal ; 206: 114385, 2021 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-34597841

RESUMO

Kai-Xin-San (KXS) is a traditional Chinese medicine (TCM) formula containing four herbal medicines: Ginseng Radix Rhizoma, Polygalae Radix, Poria and Acori Tatarinowii Rhizoma. A large number of pharmacological studies in vitro and in vivo have shown that KXS is characterized by anti-depression, anti-Alzheimer's disease, anti-oxidation and other activities. However, the pharmacodynamic substance basis studies of KXS are hitherto quite limited. Here, KXS was identified and determined by ultra-performance liquid chromatography-quadrupole-Orbitrap mass spectrometry (UPLC-Q-Orbitrap MS) and gas chromatography-mass spectrometry (GC-MS). Firstly, the data-dependent acquisition mode (DDA) of UPLC-Q-Orbitrap MS combined with the inclusion list were used to collected the chemical composition. The chemical constituents of KXS were identified by local database on compound discoverer™ 3.1 software and Xcalibur 4.1 software. With the use of this approach, a total of 211 compounds were identified from KXS. Wherein 60 compounds were from Ginseng Radix Rhizoma, 40 compounds were from Poria, and 111 compounds were from Polygala Radix, respectively. Secondly, 105 volatile constituents were identified by GC-MS analysis, which were mainly derived from Acori Tatarinowii Rhizoma. Besides, an adjusted parallel reaction monitoring method was established and validated to quantify the seventeen major compounds in different herbal medicines of KXS, which were chosen as the benchmarked substances to evaluate the quality of KXS. In conclusion, this study provided a generally applicable strategy for global metabolite identification of the complicated components and determination of multi-component content in traditional Chinese medicines.

4.
Environ Technol ; : 1-25, 2021 Sep 13.
Artigo em Inglês | MEDLINE | ID: mdl-34516339

RESUMO

Volatile organic compounds (VOCs) have caused a serious threat to the atmosphere and human health. Therefore, it is of great significance to exploit effective catalytic materials for the safe and effective catalytic elimination of VOCs. Herein, Ag-MnOx-ACF composite catalysts were constructed via a two-step impregnation strategy and used for catalytic toluene degradation. A remarkable low-temperature catalytic activity (T100 = 50℃), excellent stability, as well as CO2 selectivity (80%) were achieved over the Ag-MnOx-ACF catalyst. A series of characterizations indicated that the unique manganese defects structure of birnessite phase manganese oxide played an essential role for toluene oxidation, which was conducive to generating surface adsorbed oxygen. The higher ratio of Mn3+/Mn4+, abundant surface adsorbed oxygen and highly dispersed Ag species were determined to significantly facilitate toluene degradation. The mechanism of efficient degradation of toluene at low temperature was proposed. O3 and H2O molecules were activated via surface hydroxyl and Mn defects on Ag-MnOx-ACF to produce sufficient •OH, enhancing the degradation performance of toluene. We provide a new idea for the catalytic oxidation of benzene VOCs at low even room temperatures.

5.
Anticancer Drugs ; 2021 Sep 13.
Artigo em Inglês | MEDLINE | ID: mdl-34486535

RESUMO

Side effects of afatinib are a problem in patients with advanced non-small cell lung cancer (NSCLC). However, little is known about the occurrence of afatinib-induced hypotension. An 81-year-old man with NSCLC had an epidermal growth factor receptor-positive genotype with the p.L861Q mutation in exon 21. He was administered afatinib (40 mg/day) as anticancer therapy. Hypotension occurred twice after afatinib initiation. He suffered from dizziness and nausea. Blood pressure gradually returned to normal after afatinib cessation. Clinicians should be aware of hypotension in patients with NSCLC after afatinib initiation.

6.
Curr Med Chem ; 2021 Sep 14.
Artigo em Inglês | MEDLINE | ID: mdl-34525906

RESUMO

Sumoylation of proteins is an important reversible post-translational modification of proteins and mediates a variety of cellular processes. Sumo-modified proteins can change their subcellular localization, activity and stability. In addition, it also plays an important role in various cellular processes such as transcriptional regulation and signal transduction. The abnormal sumoylation is involved in many diseases, including neurodegeneration and immune-related diseases, as well as the development of cancer. Therefore, identification of the sumoylation site (SUMO site) is fundamental to understanding their molecular mechanisms and regulatory roles. In contrast to labor-intensive and costly experimental approaches, computational prediction of sumoylation sites in silico also attracted much attention for its accuracy, convenience and speed. At present, many computational prediction models have been used to identify SUMO sites, but these contents have not been comprehensively summarized and reviewed. Therefore, the research progress of relevant models is summarized and discussed in this paper. We will briefly summarize the development of bioinformatics methods on sumoylation site prediction. We will mainly focus on the benchmark dataset construction, feature extraction, machine learning method, published results and online tools. We hope the review will provide more help for wet-experimental scholars.

8.
Chem Rev ; 2021 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-34523916

RESUMO

Electrochemical water splitting for hydrogen generation is a promising pathway for renewable energy conversion and storage. One of the most important issues for efficient water splitting is to develop cost-effective and highly efficient electrocatalysts to drive sluggish oxygen-evolution reaction (OER) at the anode side. Notably, structural transformation such as surface oxidation of metals or metal nonoxide compounds and surface amorphization of some metal oxides during OER have attracted growing attention in recent years. The investigation of structural transformation in OER will contribute to the in-depth understanding of accurate catalytic mechanisms and will finally benefit the rational design of catalytic materials with high activity. In this Review, we provide an overview of heterogeneous materials with obvious structural transformation during OER electrocatalysis. To gain insight into the essence of structural transformation, we summarize the driving forces and critical factors that affect the transformation process. In addition, advanced techniques that are used to probe chemical states and atomic structures of transformed surfaces are also introduced. We then discuss the structure of active species and the relationship between catalytic performance and structural properties of transformed materials. Finally, the challenges and prospects of heterogeneous OER electrocatalysis are presented.

9.
Medicine (Baltimore) ; 100(35): e27126, 2021 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-34477156

RESUMO

ABSTRACT: Currently no research is available on muscle and functional performance of chronic obstructive pulmonary disease (COPD) patients with type 2 diabetes (T2DM) in China, even though both diseases have been reported to damage motor function.This single-center prospective study involves 55 males with COPD and T2DM and 46 males with COPD. Lung function, muscle strength and endurance of the upper limbs, and quadriceps strength of both legs were assessed using instruments. The 6-min walk (6MW) test was performed to evaluate physical performance.Between the two groups, respiratory function of COPD patients with T2DM was worse than in those without (P < .05). Mean handgrip strength and muscle endurance of upper limbs and mean quadriceps strength at both 60°/s and 120°/s in COPD males with T2DM was also significantly less (P < .05). Mean 6MW distances of COPD patients with T2DM were significantly worse (P < .05), and mean pulse rate (PR) increments of COPD patients with T2DM in 6MW test were significantly higher (P < .05).The combination of COPD and T2DM not only brings one more chronic disease to elderly patients but also significantly affects muscle strength and endurance as well as physical performance. Accordingly, in the management of chronic diseases, we recommend that clinicians as well as patients themselves actively control blood sugar and review them regularly with a view to reducing adverse effects on physical performance.


Assuntos
Diabetes Mellitus Tipo 2/complicações , Desempenho Físico Funcional , Doença Pulmonar Obstrutiva Crônica/fisiopatologia , Idoso , Humanos , Masculino , Pessoa de Meia-Idade , Força Muscular , Estudos Prospectivos , Doença Pulmonar Obstrutiva Crônica/complicações , Músculo Quadríceps/fisiopatologia
10.
Brief Bioinform ; 2021 Sep 22.
Artigo em Inglês | MEDLINE | ID: mdl-34553747

RESUMO

MOTIVATION: The Estimation of Model Accuracy problem is a cornerstone problem in the field of Bioinformatics. As of CASP14, there are 79 global QA methods, and a minority of 39 residue-level QA methods with very few of them working on protein complexes. Here, we introduce ZoomQA, a novel, single-model method for assessing the accuracy of a tertiary protein structure/complex prediction at residue level, which have many applications such as drug discovery. ZoomQA differs from others by considering the change in chemical and physical features of a fragment structure (a portion of a protein within a radius $r$ of the target amino acid) as the radius of contact increases. Fourteen physical and chemical properties of amino acids are used to build a comprehensive representation of every residue within a protein and grade their placement within the protein as a whole. Moreover, we have shown the potential of ZoomQA to identify problematic regions of the SARS-CoV-2 protein complex. RESULTS: We benchmark ZoomQA on CASP14, and it outperforms other state-of-the-art local QA methods and rivals state of the art QA methods in global prediction metrics. Our experiment shows the efficacy of these new features and shows that our method is able to match the performance of other state-of-the-art methods without the use of homology searching against databases or PSSM matrices. AVAILABILITY: http://zoomQA.renzhitech.com.

11.
Arch Gynecol Obstet ; 2021 Sep 20.
Artigo em Inglês | MEDLINE | ID: mdl-34542679

RESUMO

PURPOSE: Exosomes are vesicles secreted by cells that contain a wide variety of biomolecules, including proteins or nucleic acids. MicroRNAs (miRNAs), which are commonly found in exosomes, are known to play important roles in the pathophysiology of endometriosis. METHODS: This study investigated the miRNA expression profile of serum exosomes from women with endometriosis in comparison with normal controls as well as the possible role of identified miRNAs in the pathogenesis of endometriosis. Exosomes with a diameter between 60 and 100 nm were identified by their expression of exosomal marker proteins CD9 and CD63. RESULTS: Microarray miRNA expression profiling analysis revealed that 26 genes were significantly up-regulated and 19 genes were significantly down-regulated in serum exosomes from endometriosis patients compared with normal controls. These differentially expressed miRNAs were mainly enriched in the regulation of cellular development, metabolism, and involved in the regulation of the MAPK and PI3k-Akt pathways. qRT-PCR analysis verified the differential expression of three miRNAs, miR-26b-5p, miR-215-5p, and miR-6795-3p. CONCLUSION: Further analysis indicated that these differentially expressed miRNAs in serum exosomes may be involved in the pathogenesis of endometriosis and are related to the severity and certain symptoms of endometriosis.

12.
Rapid Commun Mass Spectrom ; 35(21): e9174, 2021 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-34350664

RESUMO

RATIONALE: Kaixin San (KXS) is a prescription traditional Chinese medicine (TCM) with the effects of "tonifying the kidney and brain" and "improving memory". The volatile organic compounds (VOCs) in KXS could effectively improve senile dementia and depression, but only few studies have focused on the overall characterization of VOCs in KXS and the quantitative study of the main active components. METHODS: We have developed a strategy to correlate the results from headspace gas chromatography/ion mobility spectrometry (HS-GC/IMS) and headspace gas chromatography/mass spectrometry (HS-GC/MS) for the comprehensive characterization of VOCs in KXS and the quantitative analysis of the main pharmacodynamic substances. RESULTS: A totsal of 68 low molecular weight VOCs were identified in KXS by HS-GC/IMS at room temperature and atmospheric pressure; 117 VOCs were identified and 10 components (isocalamenediol, α-asarone, ß-asarone, methyl eugenol, isoeugenol methyl ether, camphor, anethol, 2,4-di-tert-butylphol, linalool, asarylaldehyde) as the quality markers of KXS based on HS-GC/MS. CONCLUSIONS: This results from this study provide a foundation for quality control, pharmacodynamic mechanism research and further development of KXS, and provides more convincing data supporting the VOCs of other natural products.

13.
Medicine (Baltimore) ; 100(31): e26706, 2021 Aug 06.
Artigo em Inglês | MEDLINE | ID: mdl-34397807

RESUMO

BACKGROUND: The relationship between Helicobacter pylori (H. pylori) infection and nonalcoholic fatty liver disease (NAFLD) is a matter of debate. Although it has been studied in many observational studies, the results remain controversial. Therefore, we performed a meta-analysis to assess the association between H pylori infection and risk of NAFLD. METHODS: We searched Pubmed, EMBASE, and Web of Science databases, from inception to September 10, 2020. Odds ratio (OR) and 95% confidence interval (CI) were pooled by random-effects model. The statistical heterogeneity among studies (I2-index), subgroup analyses, regression analyses, sensitivity analysis and the possibility of publication bias were assessed. RESULTS: A total of seventeen studies involving 91,958 individuals were included in our meta-analysis. Meta-analysis of data from cross-sectional and case-control studies showed that H pylori infection was associated with increased risk of prevalent NAFLD (n = 15; involving 74,561 middle-aged individuals; OR1.38, 95% CI 1.23-1.55, I2 = 86.8%, P < .001). The results of meta-regression implicated that the study type and the case-control ratio impacted the total effect size. Funnel plot did not show significant publication bias. Meta-analysis of data from longitudinal studies showed that H pylori infection was also associated with increased NAFLD incidence (n = 2; involving 17397 individuals; OR 1.21, 95% CI 1.01-1.44, I2 = 6.5%, P = .301). CONCLUSIONS: The results indicated that a positive association between H pylori infection and the risk of NAFLD. Further studies are required to strengthen the association and clarify the mechanism.


Assuntos
Infecções por Helicobacter/epidemiologia , Helicobacter pylori , Hepatopatia Gordurosa não Alcoólica/epidemiologia , Estudos de Casos e Controles , Estudos Transversais , Humanos , Incidência , Estudos Observacionais como Assunto , Prevalência
14.
Brief Bioinform ; 2021 Aug 19.
Artigo em Inglês | MEDLINE | ID: mdl-34410360

RESUMO

The global pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, has led to a dramatic loss of human life worldwide. Despite many efforts, the development of effective drugs and vaccines for this novel virus will take considerable time. Artificial intelligence (AI) and machine learning (ML) offer promising solutions that could accelerate the discovery and optimization of new antivirals. Motivated by this, in this paper, we present an extensive survey on the application of AI and ML for combating COVID-19 based on the rapidly emerging literature. Particularly, we point out the challenges and future directions associated with state-of-the-art solutions to effectively control the COVID-19 pandemic. We hope that this review provides researchers with new insights into the ways AI and ML fight and have fought the COVID-19 outbreak.

15.
Artigo em Inglês | MEDLINE | ID: mdl-34444143

RESUMO

BACKGROUND: The Yi ethnic group is the sixth largest minority in China. The aim of this study was to investigate dental caries status among Yi preschool children in the Yunnan province, China. METHOD: This cross-sectional study invited 5-year-old Yi children using multistage cluster sampling. Two trained and calibrated dentists examined the children in kindergartens. The children's dental caries experience was assessed using the decayed, missing, and filled teeth (dmft) index. Visual plaque on an indexed tooth of each six sextants was recorded and the oral hygiene status was assessed using the Visible Plaque Index. Parents completed questionnaires that surveyed their educational attainment. The questionnaires also collected information about the children's demographics, snacking habits, oral-health-related behaviors and dental visit experiences. The associations between caries experiences and potential factors were analyzed using zero-inflated negative binomial regression. RESULTS: All 452 invited children (249 boys, 55%) participated in this study with a response rate of 100%. Dental caries prevalence rate was 83%. The mean dmft score and decayed teeth score were 5.2 ± 4.4 and 5.1 ± 4.4, respectively. Almost half of the children (n = 211, 47%) had visible plaque on four or more of the six sextants. Most (n = 366, 81%) of the children had not visited a dentist in the prior 12 months. Regression analysis found the children's caries experience was associated with their dental visit experience. CONCLUSION: The great majority of the Yi preschool children experienced dental caries and almost all of the cavities were not restored. Their oral hygiene was poor and visible plaque was commonly found on their teeth.


Assuntos
Cárie Dentária , Pré-Escolar , China/epidemiologia , Estudos Transversais , Índice CPO , Cárie Dentária/epidemiologia , Humanos , Masculino , Saúde Bucal , Prevalência
16.
IEEE Trans Biomed Eng ; PP2021 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-34460361

RESUMO

AbstractObjective: Understanding medical images like the human surgeon is a challenge for current surgical robots. It is still hard for surgical robots to achieve safe and stable operations with the help of priori information from preoperative images. We proposed a method to estimate drilling force information based on preoperative images, which can provide priori force information for surgical robots to perform bone drilling tasks. METHODS: A visual sensing computing framework is proposed to obtain the 3D image information from the drill-tissue contact area in a one-dimensional signal format. Under this computing framework, a computed tomography (CT) image-weighted bone drilling mechanical model is built. The model considers both targets bone shape and material properties to predict the thrust force, torque, and radial force of a drilling process based on preoperative CT images. RESULTS: The built model can respond to multiple bone drilling process factors, such as personalized surgery plans, varying tissue densities, uneven drilling surfaces, different drilling speeds, feed rates, and drill bit geometries. The minimum error of the predicted thrust force on bovine bones is 1.130.95 N, and the best normalized average prediction error on porcine bones is 0.070.08. Experiments in spinal pedicle screw placement surgery also show potential application abilities. CONCLUSION: Our method predicts the bone drilling force well based on preoperative images, providing robots with more efficient preoperative information. SIGNIFICANCE: This work offers a new perspective to study the interaction relationship between robot surgical instruments and tissues with the assistance of preoperative images.

17.
Artigo em Inglês | MEDLINE | ID: mdl-34387026

RESUMO

The exploration of novel systems for the electrochemical CO2 reduction reaction (CO2 RR) for the production of hydrocarbons like CH4 remains a giant challenge. Well-designed electrocatalysts with advantages like proton generation/transferring and intermediate-fixating for efficient CO2 RR are much preferred yet largely unexplored. In this work, a kind of Cu-porphyrin-based large-scale (≈1.5 µm) and ultrathin nanosheet (≈5 nm) has been successfully applied in electrochemical CO2 RR. It exhibits a superior FE CH 4 of 70 % with a high current density (-183.0 mA cm-2 ) at -1.6 V under rarely reported neutral conditions and maintains FE CH 4 >51 % over a wide potential range (-1.5 to -1.7 V) in a flow cell. The high performance can be attributed to the construction of numerous hydrogen-bonding networks through the integration of diaminotriazine with Cu-porphyrin, which is beneficial for proton migration and intermediate stabilization, as supported by DFT calculations. This work paves a new way in exploring hydrogen-bonding-based materials as efficient CO2 RR catalysts.

18.
Environ Res ; 201: 111618, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-34237337

RESUMO

Glyphosate, a common broad-spectrum herbicide, is a serious environmental pollutant that causes a significant threat to humans. Hence, there is a pressing task to remove glyphosate from the environment. Here, we report an excellent Fe3Ce1Ox catalyst synthesized via the one-step co-precipitation method for activating peroxymonosulfate (PMS) to degrade glyphosate at 25 °C. As a result, glyphosate is completely degraded with a high degradation rate of 400 mg L-1·h-1, and the TOC and TN removals are 85.6% and 80.8%, respectively. As proven by systematic characterizations, the Fe-Ce synergistic effect plays a significant role in promoting PMS activation. The main reactive oxygen species for glyphosate oxidation are surface-bound SO4-· and ·OH, produced by activating PMS by electron transfer between Fe2+/Fe3+ and Ce3+/Ce4+ of Fe3Ce1Ox. In light of the products determined, the possible degradation process of glyphosate is also speculated: C-N and C-P bonds of glyphosate molecules are attacked to form aminomethylphosphonic acid (AMPA) and orthophosphate (PO43-) by surface-bound SO4-· and ·OH that continuously mineralize and dephosphorylate AMPA to generate small molecules and inorganic ions, such as H2O and PO43-. The results of this work suggest that Fe3Ce1Ox/PMS could provide a potential candidate for efficiently removing organic compounds containing nitrogen or phosphorus from wastewater.


Assuntos
Temperatura , Glicina/análogos & derivados , Humanos , Organofosfonatos , Peróxidos
19.
Math Biosci Eng ; 18(4): 3348-3363, 2021 04 15.
Artigo em Inglês | MEDLINE | ID: mdl-34198389

RESUMO

N4-methylcytosine (4mC) is a kind of DNA modification which could regulate multiple biological processes. Correctly identifying 4mC sites in genomic sequences can provide precise knowledge about their genetic roles. This study aimed to develop an ensemble model to predict 4mC sites in the mouse genome. In the proposed model, DNA sequences were encoded by k-mer, enhanced nucleic acid composition and composition of k-spaced nucleic acid pairs. Subsequently, these features were optimized by using minimum redundancy maximum relevance (mRMR) with incremental feature selection (IFS) and five-fold cross-validation. The obtained optimal features were inputted into random forest classifier for discriminating 4mC from non-4mC sites in mouse. On the independent dataset, our model could yield the overall accuracy of 85.41%, which was approximately 3.8% -6.3% higher than the two existing models, i4mC-Mouse and 4mCpred-EL respectively. The data and source code of the model can be freely download from https://github.com/linDing-groups/model_4mc.


Assuntos
Citosina , DNA , Animais , Biologia Computacional , Genoma , Aprendizado de Máquina , Camundongos , Software
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