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1.
Int J Mol Sci ; 22(17)2021 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-34502323

RESUMO

The aim of the study was the multi-elemental analysis of aqueous humor (AH) collected from patients undergoing cataract surgery. The study included: 16 patients with age-related macular degeneration AMD (99 controls), 10 patients with retinopathy (105 controls), 61 patients with hypertension (54 controls), and 33 patients with coexisting diabetes (82 controls). The control groups were recruited from patients with a lack of co-existing disease characterizing the specified studied group. The measurements were performed by the use of inductively coupled plasma optical emission spectrometry (ICP-OES). The statistical analysis was carried out using non-parametric testing (Mann-Whitney U). The level of significance was set at p = 0.05. The data obtained revealed substantial variations in elemental composition between the test groups in comparison to the controls. However, the significant variations concerned only a few elements. The phosphorous (P) level and the ratio of P/Ca were significant in retinopathy and diabetes, whereas cobalt (0.091 ± 0.107 mg/L vs. 0.031 ± 0.075 mg/L; p = 0.004) was significant in AMD. In co-existing hypertension, the levels of tin (0.293 ± 0.409 mg/L vs. 0.152 ± 0.3 mg/L; p = 0.031), titanium (0.096 ± 0.059 mg/L vs. 0.152 ± 0.192 mg/L; p = 0.045), and ruthenium (0.035 ± 0.109 mg/L vs. 0.002 ± 0.007 mg/L; p = 0.006) varied in comparison to the controls. The study revealed inter-elemental interactions. The correlation matrices demonstrated the domination of the positive correlations, whereas negative correlations mainly concerned sodium.


Assuntos
Humor Aquoso/metabolismo , Catarata/metabolismo , Diabetes Mellitus/fisiopatologia , Retinopatia Diabética/fisiopatologia , Elementos Químicos , Hipertensão/fisiopatologia , Degeneração Macular/fisiopatologia , Idoso , Idoso de 80 Anos ou mais , Estudos de Casos e Controles , Catarata/epidemiologia , Catarata/patologia , Catarata/terapia , Extração de Catarata , Feminino , Seguimentos , Humanos , Cristalino/cirurgia , Masculino , Pessoa de Meia-Idade , Polônia/epidemiologia , Prognóstico
2.
Ann Agric Environ Med ; 28(2): 243-249, 2021 Jun 14.
Artigo em Inglês | MEDLINE | ID: mdl-34184505

RESUMO

OBJECTIVE: The aim of the study was to explore the influence of exudative age-related macular degeneration on the quality of life of patients from urban and rural areas. MATERIAL AND METHODS: The retrospective study included 144 Polish Caucasians with exudative age-related macular degeneration, treated with anti-VEGF, recruited from Department of Medical Retina in Lublinbetween March and June 2017. Clinical assessment included age, gender, visual acuity, complete ophthalmic examination, fundus fluorescein angiography and optical coherence tomography, medical history and the NEI VFQ-25 questionnaire. RESULTS: The mean age of the study group was 76.73±12.3 years, average time of AMD was 4.24±4.1 years. 21.5% of patients reported comorbidities such as hypertension, cardiovascular disease, diabetes mellitus. 99 (68.75%) lived in a city, while 45(31.25%) in a village. There was a tendency of females to complain more than males about moderate and severe discomfort and pain (p = 0.09). Most of the patients did not drive a car before the onset of the disease (female vs.male: 81% vs 62.9%; p = 0.01). 62.8% males and 25.8% females gave up driving (p = 0.003), whereas significantly more males gave up driving' and 25% of villagers gave up driving (p = 0.07). The parameter because of the eyesight - female vs. male: 50% vs. 20.8%; p = 0.03. There was a tendency of village respondents to complain more often about extreme difficulty in reading newspapers, street signs or the names of stores than (p = 0.08). 44.2% city residents. Rural patients felt to achieve much less because of their eyesight, which was not observed in patients from the city (p = 0.06). CONCLUSIONS: The place of residence and gender influenced perception of the disease in exudative form of age-related macular degeneration.


Assuntos
Degeneração Macular/psicologia , População Rural/estatística & dados numéricos , População Urbana/estatística & dados numéricos , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Degeneração Macular/fisiopatologia , Masculino , Pessoa de Meia-Idade , Qualidade de Vida , Estudos Retrospectivos , Acuidade Visual
3.
Front Pharmacol ; 12: 656774, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33995079

RESUMO

Purpose: To evaluate the effect of repeated intravitreal bevacizumab injections on blood-aqueous barrier permeability in eyes with neovascular age-related macular degeneration (AMD). Patients and Methods: Forty-eight consecutive patients with neovascular AMD received 3 intravitreal bevacizumab injections (1 mg) every 30-40 days. Subjects were followed for a period of 4 months and were examined at baseline, 1 day and 1 month after each injection. A control group comprised of 19 neovascular AMD patients waiting to begin anti-vascular endothelial growth factor (VEGF) therapy. Anterior chamber (AC) inflammation was evaluated with biomicroscopy and laser flare photometry. Results: None of the subjects treated with bevacizumab had detectable ocular inflammation during follow-up. An analysis for variance (ANOVA) of the mixed-effects model has shown neither an effect between treatment and control group (p = 0.921), nor over the time course of the follow-up (p = 0.773). Before treatment, median AC inflammation was 6.7 photons/ms (range: 3.5-18.2 photons/ms). One month after the first, second, and third injections, median laser flare was 6.4, 6.8, and 6.6 photons/ms, respectively, none of which were significantly different from baseline (all p > 0.05). Blood-aqueous barrier permeability did not change between injections and was not different from the control group. Conclusion: Inflammation induced by intravitreal bevacizumab was not detected by examination or flare photometry. This suggests that monthly bevacizumab dosing seems to be safe. The absence of AC inflammation could also reflect the known anti-inflammatory properties of anti-VEGF agents.

4.
Artigo em Inglês | MEDLINE | ID: mdl-33809199

RESUMO

The coronavirus SARS-CoV-2 responsible for the current human COVID-19 pandemic has shown tropism toward different organs with variable efficiency, eyes included. The purpose of this study has been to investigate the presence of detectable SARS-CoV-2 infection in ocular swabs in patients affected by COVID-19. A consecutive series of 74 COVID-19-positive patients (age 21-89) were enrolled at two Polish COVID-19 hospitals for 4 months and were characterized by PCR for the presence of the SARS-CoV-2 genetic material in nasopharyngeal (NP) and ocular swabs, while their respiratory and ocular symptoms were noted. Almost 50% of them presented with severe/critical respiratory involvement, and some degree of eye disease. No tight correlation was observed between the presence of ocular and respiratory symptoms. Three male patients presenting with severe/critical lung disease tested positive in ocular swab, however with mild/moderate ocular symptoms. In conclusion, our study lends further support to the view that overt ocular infection by the SARS-CoV-2 virus is not such a frequent occurrence.


Assuntos
COVID-19 , Infecções por Coronavirus , Adulto , Idoso , Idoso de 80 Anos ou mais , Humanos , Masculino , Pessoa de Meia-Idade , Pandemias , Polônia , SARS-CoV-2 , Adulto Jovem
5.
Eur J Ophthalmol ; 30(3): 586-594, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32347762

RESUMO

PURPOSE: To report 12-month outcomes of a Polish National Treatment Program using aflibercept and ranibizumab in eyes with wet, age-related macular degeneration in routine clinical practice. MATERIAL AND METHODS: This was a non-randomized, retrospective, observational multicenter study. Anonymous data contained in the electronic Therapeutic Program Monitoring System were utilized in this study. RESULTS: The study population consisted of 2828 eyes from 2718 patients. The median age was 76.0 [70.0, 81.0] years; 61.7% were female. Best corrected visual acuity increased from 58.86 [50.05, 69.95] letters to 65.1 [50.1, 73.9] letters (p < 0.001). The median change in best corrected visual acuity was 0.0 [-4.0, 12.2] letters: 2.9 [-2.9, 15.1] letters for treatment-naïve eyes and 0.0 [-4.0, 8.8] letters for those continuing treatment (p < 0.001). The median central retinal thickness was significantly reduced from 341.0 [281.0, 422.0] to 275.0 [221.0, 344.0] µm (p < 0.001). The median number of visits was 9.0 [8.0, 9.0]. The median number of injections was 7.0 [6.0, 8.0]: 8.0 [7.0, 8.0] for treatment-naïve eyes and 6.0 [5.0, 7.0] for those continuing treatment (p < 0.001). CONCLUSION: Eyes treated as part of the Polish therapeutic program gained functional stability and morphological improvement. Treatment-naïve eyes showed the greatest functional benefit.


Assuntos
Inibidores da Angiogênese/uso terapêutico , Neovascularização de Coroide/tratamento farmacológico , Ranibizumab/uso terapêutico , Receptores de Fatores de Crescimento do Endotélio Vascular/uso terapêutico , Proteínas Recombinantes de Fusão/uso terapêutico , Degeneração Macular Exsudativa/tratamento farmacológico , Idoso , Idoso de 80 Anos ou mais , Neovascularização de Coroide/diagnóstico , Neovascularização de Coroide/fisiopatologia , Feminino , Seguimentos , Humanos , Injeções Intravítreas , Masculino , Polônia , Retina/fisiopatologia , Estudos Retrospectivos , Resultado do Tratamento , Fator A de Crescimento do Endotélio Vascular/antagonistas & inibidores , Acuidade Visual/fisiologia , Degeneração Macular Exsudativa/diagnóstico , Degeneração Macular Exsudativa/fisiopatologia
6.
Molecules ; 24(22)2019 Nov 14.
Artigo em Inglês | MEDLINE | ID: mdl-31739645

RESUMO

Trace elements play an important role in the pathogenesis of several serious ophthalmological disorders, such as glaucoma, age-related macular degeneration (AMD), diabetic retinopathy, cataract, etc. This study aimed to measure alterations of chemical elements' (67) levels in the aqueous humor of patients undergoing cataract surgery. The pilot study included 115 patients, (age 74 ± 7.27, female 64.35%, male 35.65%). The aqueous levels of elements were measured by the use of the inductively coupled plasma optical emission spectrometry (ICP-OES), quality controlled with certified standards. The classification of elements based on their concentration was achieved by hierarchical cluster analysis. This is the first screening study that quantifies over 60 elements which are present in the fluid from the anterior chamber of the eye of cataract patients. The obtained results can be suitable for understanding and identifying the causes that may play a role in the initiation and progression of lens opacity.


Assuntos
Humor Aquoso/química , Catarata/metabolismo , Oligoelementos/análise , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Projetos Piloto
7.
Semin Ophthalmol ; 34(3): 146-156, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31060414

RESUMO

Myopic foveoschisis (MF) is common in highly myopic eyes with posterior staphyloma, and optical coherence tomography is essential for establishing the diagnosis and monitoring disease progression. Untreated MF may lead to significant visual loss due to secondary complications. Vitrectomy with or without internal limiting membrane peeling followed by gas tamponade is the standard treatment; however, in recent years, new techniques, including macular buckling, have been introduced. We selected a total of 41 articles with 30 describing various modifications of pars plana vitrectomy, six describing the macular buckling technique, and five reporting combined surgery. The present review describes current MF treatment strategies, including outcomes, and provides a comprehensive understanding of current therapeutic options. Early detection and surgical intervention in eyes with specific risk factors may contribute to both improved visual recovery and more favorable anatomical outcomes.


Assuntos
Miopia Degenerativa , Retinosquise , Técnicas de Diagnóstico Oftalmológico , Humanos , Macula Lutea/cirurgia , Miopia Degenerativa/diagnóstico , Miopia Degenerativa/cirurgia , Retinosquise/diagnóstico , Retinosquise/cirurgia , Fatores de Risco , Tomografia de Coerência Óptica , Vitrectomia/métodos
8.
Molecules ; 23(11)2018 Nov 17.
Artigo em Inglês | MEDLINE | ID: mdl-30453653

RESUMO

Tryptophan (TRP) is to an essential amino acid and its catabolites are significant to human health. By using ultra-high-performance liquid chromatography coupled to electrospray ionization triple quadrupole mass spectrometry (UHPLC-ESI-MS/MS), levels of three major components of kynurenic pathway namely tryptophan (TRP), kynurenic acid (KYNA) and kynurenine (KYN) in fluid from the anterior chamber of the eye were determined. The analysis was carried out on a Synergi 4 µ Fusion-RP column using gradient elution mode. For quantitative determination, l-tryptophan-amino-15N, 99 ATOM % 15N was used as an internal standard. The method was linear in the concentration range 4⁻2000 ng mL-1 for TRP, KYNA and KYN. The mean recoveries measured at four concentration levels for TRP, KYN and KYNA included the following ranges 94.3⁻96.1; 91.0⁻95.0; and 96.0⁻97.6%, respectively. The intra-day precision parameters were smaller than 4.4, 6.4 and 5% respectively. The developed method was applied to study the level of TRP, KYNA and KYN in eye fluid for the retrospective case series which included 28 patients suffering from cataracts and diabetes (n = 8). The experimental data was subjected to statistical analysis. The Mann-Whitney U-test revealed clear differences in the level of TRP catabolites and the ratios of TRP/KYN representing the activities of specific enzyme of kynurenine pathway in examined groups of patients. A level of probability p < 0.05 was used throughout a paper to denote statistically significant differences between the groups.


Assuntos
Câmara Anterior/metabolismo , Catarata/metabolismo , Diabetes Mellitus/metabolismo , Triptofano/química , Triptofano/metabolismo , Cromatografia Líquida , Cinurenina/metabolismo , Redes e Vias Metabólicas , Espectrometria de Massas em Tandem
9.
J Ophthalmol ; 2018: 9479848, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29725542

RESUMO

Purpose: To investigate retinal sensitivity characteristics associated with morphologic changes in the eyes exhibiting chronic central serous chorioretinopathy (CSC), using macular integrity assessment (MAIA) microperimetry. Methods: A retrospective, cross-sectional, observational study was constructed. The eyes of patients classified as chronic CSC, according to the onset of subjective symptoms with serous retinal detachment, as confirmed by optical coherence tomography examination, were included in the study. Retinal sensitivity and fixation were analyzed by performing microperimetry examinations using the MAIA instrument. Results: We reviewed microperimetry examinations of 15 eyes of 15 patients (age: 28-51 years) with chronic CSC and mean best-corrected visual acuity of -0.2 logMAR units. The mean retinal integrity in the chronic CSC group was 49.0 ± 27.6, which was significantly different from the control eyes. The mean average threshold in the eyes with chronic CSC was 24.7 ± 5.8 dB, which also was significantly different from the control eyes. Fixation stability was significantly different between the CSC and control eyes for the P1 parameter (90.1 ± 13.7 versus 99.3 ± 1.5), and for the P2 parameter (97.4 ± 4.0 versus 100.0 ± 0.0). Conclusion: New microperimetry technology may provide valuable information regarding the visual status of chronic CSC cases. Our findings suggest that retinal sensitivity and fixation stability in chronic CSC eyes may serve as useful indicators for assessing the effectiveness of clinical treatments.

10.
Klin Oczna ; 118(1): 41-43, 2016 Aug.
Artigo em Inglês, Polonês | MEDLINE | ID: mdl-29715407

RESUMO

Optic disc pit is a congenital optic disc anomaly, which can be associated with maculopathy. The case of an unusually nasally located pit with concomitant maculopathy in a 64-year-old woman is presented.


Assuntos
Macula Lutea/diagnóstico por imagem , Disco Óptico/anormalidades , Doenças Retinianas/complicações , Feminino , Humanos , Pessoa de Meia-Idade , Disco Óptico/diagnóstico por imagem , Descolamento Retiniano/complicações , Descolamento Retiniano/diagnóstico por imagem , Doenças Retinianas/diagnóstico por imagem , Tomografia de Coerência Óptica
11.
Klin Oczna ; 117(4): 221-224, 2016 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-29727106

RESUMO

AIM OF THE STUDY: To evaluate the efficacy of intravitreal aflibercept administered to patients with exudative age-related macular degeneration. MATERIALS AND METHODS: 70 patients with exudative age-related macular degeneration confirmed clinically and in additional diagnostic procedures (fluorescein angiography and spectral domain-optical coherence tomography) were enrolled. All patients were administered three doses of intravitreal aflibercept at one-month intervals. Some patients (seven) received an additional injection of the drug two months after the last of the three injections. The best-corrected visual acuity and the optical coherence tomography findings were assessed at baseline and after the treatment. RESULTS: At baseline, the mean best corrected visual acuity was 0.20. After the injection of aflibercept it improved to the mean value of 0.32 with the difference being statistically significant (p < 0.001, Student's t-test). The mean central subfield thickness at baseline was 311.4 µm. It decreased to mean value of 254.5 pµn with the difference being statistically significant (p<0.001, Student's t-test). CONCLUSIONS: Intravitreal injections of aflibercept improved clinical and anatomical parameters in patients with exudative age-related macular degeneration in the initial phase of treatment.


Assuntos
Degeneração Macular/tratamento farmacológico , Receptores de Fatores de Crescimento do Endotélio Vascular/uso terapêutico , Proteínas Recombinantes de Fusão/uso terapêutico , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Injeções Intravítreas , Degeneração Macular/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Receptores de Fatores de Crescimento do Endotélio Vascular/administração & dosagem , Proteínas Recombinantes de Fusão/administração & dosagem , Tomografia de Coerência Óptica , Resultado do Tratamento
12.
Klin Oczna ; 117(2): 119-22, 2015.
Artigo em Polonês | MEDLINE | ID: mdl-26638551

RESUMO

Geographic atrophy is a manifestation of the advanced age-related macular degeneration and form of irreversible atrophy of retinal pigment epithelium and photoreceptor layer. Early detection of changes and the ability to evaluate disease progression accurately constitute a key problem in diagnosis and treatment planning. Fundus autofluorescence is a relatively new imaging method considered nowadays to be the best in diagnosis and observing the natural or treatment-altered course of disease. High resolution images showing the 3D distribution of retinal pigment epithelium autofluorescence as lipofuscin index can be obtained owing to the launch of the confocal scanning laser ophthalmoscope.


Assuntos
Fundo de Olho , Atrofia Geográfica/patologia , Epitélio Pigmentado Ocular/patologia , Fluorescência , Atrofia Geográfica/diagnóstico , Humanos
13.
Klin Oczna ; 117(3): 173-6, 2015.
Artigo em Polonês | MEDLINE | ID: mdl-26999941

RESUMO

Central serous chorioretinopathy is a common retinopathy, which is manifested by the idiopathic detachment of the neurosensory retina in the posterior pole, secondary to fluid leakage from choroidal vessels at the level of retinal pigment epithelium. The disease is typically unilateral and affects young men. We present a case of a 48-year old man, admitted to the Department of Vitreo-Retinal Surgery, Medical University in Lublin, reporting vision impairment in his right eye. The bilateral ocular exam followed by optical coherence tomography, ultra-widefield fluorescein angiography and microperimetry revealed bilateral central serous chorioretinopathy. This case presents a bilateral manifestation of central serous chorioretinopathy and emphasizes the role of advanced diagnostic imaging techniques in analyzing retinal function and disease management.


Assuntos
Coriorretinopatia Serosa Central/diagnóstico , Angiofluoresceinografia , Tomografia de Coerência Óptica , Testes de Campo Visual , Coriorretinopatia Serosa Central/diagnóstico por imagem , Coriorretinopatia Serosa Central/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Radiografia
14.
Klin Oczna ; 115(2): 141-3, 2013.
Artigo em Polonês | MEDLINE | ID: mdl-24059031

RESUMO

PURPOSE: We describe a case of choroidal folds coexisting with ethmoidal myxoma and the evolution of folds after tumor excision. Choroidal folds can occure in the case of intraorbital pathology. Optical coherence tomography is usefull in diagnosis and monitoring of these folds. MATERIAL AND METHODS: 45 years old woman was reffered to our clinic because of visal disturbances in her right eye. Visual acuity of right eye was 0.5, of the left eye 1.0. Intraocular pressure of both eyes was within normal limits. Biomicroscopic evaluation of the right eye revealed no changes in anterior segment but choroidal folds in posterior segment were evident. The left eye was normal. Computer tomography of the orbit documented the presence of tumor within the right ethmoid. The tumor was excised surgically and its myxoidal nature was confirmed. RESULTS: 3 months after that intervention retinal profile in posterior pole in optical coherence tomography was normal and visual acuity of right eye improved by 1 line in Snellen chart. CONCLUSIONS: Choroidal folds caused by ethmoidal myxoma can disapper after surgical excison of tumor. Optical coherence tomography is very useful in documentation of these changes.


Assuntos
Doenças da Coroide/diagnóstico , Seio Etmoidal/patologia , Seio Etmoidal/cirurgia , Mixoma/cirurgia , Neoplasias dos Seios Paranasais/cirurgia , Tomografia de Coerência Óptica/métodos , Corioide/patologia , Doenças da Coroide/etiologia , Doenças da Coroide/cirurgia , Feminino , Humanos , Pessoa de Meia-Idade , Mixoma/complicações , Mixoma/patologia , Neoplasias dos Seios Paranasais/complicações , Neoplasias dos Seios Paranasais/patologia , Resultado do Tratamento , Acuidade Visual
15.
Klin Oczna ; 114(1): 26-8, 2012.
Artigo em Polonês | MEDLINE | ID: mdl-22783740

RESUMO

PURPOSE: To present qualitative and quantitative changes in OCT image evolving during time in eyes with central retinal artery occlusion. MATERIAL AND METHODS: Results of OCT examination of 8 patients with central retinal artery occlusion were studied. The patients age ranged from 56 to 81 years (median - 63). The Group consisted of 5 men and 3 women. Follow-up period ranged from 6 o 28 months (median - 14 months). Patients were examined in acute stage of CRAO (1-3 days), 1, 3, 6, 9, 12 and 24 months after CRAO episode. The OCT examination was performed using Cirrus OCT (Zeiss) and macular region analyzed using a standard scanning protocol Macula Thickness: Macular Cube 512x128. RESULTS: In an acute stage of CRAO increased thickness and hyperreflectivity of the inner retinal layers with corresponding hyporeflectivity layer below was detected. During follow-up period thickness of inner retinal layers and total retinal thickness gradually decreased. The other retinal layers presented increased reflectivity over time. After 6 months of observation we observed an atrophy of the retinal layers and lack of fovea profile in all cases. CONCLUSIONS: The SD-OCT examination appears to be a perfect method for the determination of the dynamics of the edematous and atrophic changes evolving after CRAO in the macular area.


Assuntos
Artérias Ciliares/patologia , Corpo Ciliar/irrigação sanguínea , Oclusão da Artéria Retiniana/diagnóstico , Idoso , Idoso de 80 Anos ou mais , Progressão da Doença , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Polônia , Retina/patologia , Oclusão da Artéria Retiniana/patologia , Tomografia de Coerência Óptica/métodos , Acuidade Visual
16.
Klin Oczna ; 114(1): 41-3, 2012.
Artigo em Polonês | MEDLINE | ID: mdl-22783744

RESUMO

PURPOSE: We describe a case of peripapillary myelinated retinal nerve fibers complicated by epiretinal membrane in region of macula. MATERIAL AND METHODS: 72 years old man was refered to our Clinic with suspicion of retinal detachment of right eye. Visual acuity of right eye was based to 0.05, in left eye was 0.5. IOP was normal in both eyes. In biomcroscopic evaluation the slight cortical cataract was observed in both eyes. Stereoscopic evaluation of right eye revealed the presence of massive peripapillary myelinated retinal nerve fibers and epiretinal membrane in the macula. In the left eye the less intense peripapillary myelinated retinal nerve fibers were noticed as well and the macular region was unchanged. With the use of OCT examination of the retina the presence of epiretinal membrane in the right eye was confirmed. OCT in the fellow eye presented an undisturbed foveal profile without any epiretinal abnormalities. CONCLUSIONS: Myelinated retinal nerve fibers can be complicated by epiretinal membrane. Probably the presence of macular pathologies depends on the extensions of nerve fibers. OCT examination is very helpful to give a proper diagnosis.


Assuntos
Membrana Epirretiniana/patologia , Macula Lutea/patologia , Degeneração Macular/patologia , Fibras Nervosas Mielinizadas/patologia , Fibras Nervosas/patologia , Idoso , Membrana Epirretiniana/complicações , Humanos , Degeneração Macular/complicações , Masculino , Descolamento Retiniano/complicações , Tomografia de Coerência Óptica , Acuidade Visual
18.
Klin Oczna ; 113(10-12): 326-30, 2011.
Artigo em Polonês | MEDLINE | ID: mdl-22384649

RESUMO

PURPOSE: To evaluate retinal pigment epithelium (FIPE) and photoreceptors layer integrity in different stages of AMO based on fundus autofluorescence imaging and to correlate autofluorescence images with visual acuity. MATERIAL AND METHODS: 322 eyes of 200 patients with different forms and stages of AMD were studied. Mean age was 70 years (49-91 years). Apart from complete ophthalmologic examination patients were examined every 6 months by using a confocal scanning ophthalmoscope HRA2. Follow-up period ranged trom 1 to 40 months (mean--18 months). RESULTS: In 116 eyes with early AMO punctuate changes in autofluorescence images were observed while in 22 eyes (16%) no distinct changes were present. In 52 eyes (62%) with wet AMD normal or near normal autotluorescence signal was present and 34 eyes (38%) with wet AMO had changes in autofluorescence signal corresponding with choroidal neovascularisation (WV) area. In the group of eyes with autofluorescence changes in the CNV area median BCVA was 0.1 and in the group without autofluorescence changes within the CNV area--0.4. All eyes with disciform scar were characterized by uneven autofluorescence signal decrease in scar area with increased signal in surroundig area. Eyes with geographic atrophy (GA) had lack of autofluorescence signal corresponding to RPE atrophy and in 40 cases (95%) increase autofluorescence signal junctional to GA was noted. CONCLUSIONS: Fundus autofluorescence images of the AMO eyes varies greatly. Decrease of autofluorescence signal correlates with visual acuity decrease.


Assuntos
Angiofluoresceinografia/métodos , Fundo de Olho , Atrofia Geográfica/patologia , Epitélio Pigmentado Ocular/patologia , Degeneração Macular Exsudativa/patologia , Idoso , Idoso de 80 Anos ou mais , Atrofia Geográfica/metabolismo , Humanos , Pessoa de Meia-Idade , Oftalmoscopia/métodos , Epitélio Pigmentado Ocular/metabolismo , Polônia , Acuidade Visual , Degeneração Macular Exsudativa/metabolismo
19.
Klin Oczna ; 112(4-6): 124-6, 2010.
Artigo em Polonês | MEDLINE | ID: mdl-20825066

RESUMO

PURPOSE: To evaluate the relationship between isolated focal retinal pigment epithelium (RPE) proliferation and development of occult choroidal neovascularisation. MATERIAL AND METHODS: The natural clinical course of 43 eyes of 39 patients was analyzed. Patients with RPE proliferation as an isolated manifestation of retinal degeneration were included in this study. The mean age of patients was 75.0 (69-94). The mean observation period was 41.4 months (6-63). RESULTS: In 30 eyes (70%), occult choroidal neovascularisation occurred, in 13 eyes (30%), that complication was not observed. The development of neovascularisation was correlated with the presence of neovascular membrane in the fellow eye. CONCLUSIONS: Based on presented data we can estimate that isolated focal proliferation of retinal pigment epithelium is an important risk factor for the development of occult choroidal neovascularisation.


Assuntos
Proliferação de Células , Epitélio Pigmentado Ocular/patologia , Neovascularização Retiniana/diagnóstico , Neovascularização Retiniana/etiologia , Idoso , Idoso de 80 Anos ou mais , Feminino , Angiofluoresceinografia , Humanos , Masculino , Pessoa de Meia-Idade , Polônia , Fatores de Risco
20.
Klin Oczna ; 109(4-6): 146-9, 2007.
Artigo em Polonês | MEDLINE | ID: mdl-17725273

RESUMO

PURPOSE: To evaluate effects of intravitreal bevacizumab on visual acuity and angiographic lesions characteristics in patients with neovascular AMD and to report safety of such treatement. MATERIAL AND METHODS: 32 patients with confirmed choroidal neovascularisation (CNV) and AMD were treated. Patients received 2 intravitreal bevacizumabu (1.25 mg) iniections on 1-3 months basis. Control ophthalmic evaluations included visual acuity measurements with EDTRS charts, intraocular pressure measurements, complete ophthalmic examination in slit lamp, fluorescein angiography and blond pressure measurements. RESULTS: In 18 patients (56%) visual acuity improvement at a mean 3 lines on EDTRS charts was observed, in 9 patients (28%) visual acuity did not change and in 5 (16%) cases decreased visual acuity (about 1,5 lines in EDTRS charts) was noted. Mean follow-up period was 3 months after second injection. In most study eyes fluorescein angiography revealed a marked reduction in leakage from CNV. Apart from one case with endophthalmitis symptoms after second bevacizumab injection, we did not observed systemic or ocular adverse effects of the applied treatment. CONCLUSIONS: Short-term results suggest that intravitreal bevacizumab is relatively safe form of AMD treatement and is associated with improvement in visual acuity and reduction in angiographic leakage in most patients with neovascular AMD. Further evaluation of the long-term effectiveness of this treatment is warranted.


Assuntos
Inibidores da Angiogênese/uso terapêutico , Anticorpos Monoclonais/uso terapêutico , Neovascularização de Coroide/tratamento farmacológico , Degeneração Macular/tratamento farmacológico , Acuidade Visual/efeitos dos fármacos , Idoso , Idoso de 80 Anos ou mais , Inibidores da Angiogênese/farmacologia , Anticorpos Monoclonais/farmacologia , Anticorpos Monoclonais Humanizados , Bevacizumab , Neovascularização de Coroide/etiologia , Feminino , Angiofluoresceinografia , Humanos , Injeções , Pressão Intraocular , Degeneração Macular/complicações , Masculino , Pessoa de Meia-Idade , Fator A de Crescimento do Endotélio Vascular/efeitos dos fármacos , Corpo Vítreo
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