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1.
Artigo em Inglês | MEDLINE | ID: mdl-36725347

RESUMO

BACKGROUND: The impact of sensory impairment (SI) on individual multidimensional health has not been adequately explored in developing countries. This study examined the association of hearing or/and visual impairment with health-related quality of life (HRQoL) in the Chinese middle-aged and older population, and further explored potential discrepancies in associations by gender and rural-urban residence. METHODS: This cohort study used four-wave data during 2011-2018 from the China Health and Retirement Longitudinal Study, and enrolled 13 342 community-dwelling adults aged 45 years or older. We employed linear mixed effects models to estimate the longitudinal associations between SI and HRQoL, and conducted interaction tests to assess gender or rural-urban differences in above associations. RESULTS: Hearing impairment (HI) and visual impairment (VI) were separately and jointly associated with deteriorated overall HRQoL and decreased physical/mental component of HRQoL (all ß<0, all p<0.05), and in particular, dual sensory impairment (DSI) exhibited greater impacts on HRQoL than either HI or VI alone. The impacts of SI on HRQoL were more evident among women or rural population than their counterparts (all p for interaction<0.05). CONCLUSION: This study observed decreased HRQoL in association with SI. The greater impact of DSI underlines the need for integrated care for comorbid sensory conditions. Our findings also indicate the necessity to reduce the burden of SI among more vulnerable populations such as females and rural adults.

3.
Nanoscale ; 2023 Jan 31.
Artigo em Inglês | MEDLINE | ID: mdl-36723119

RESUMO

In this work, ultra-small core-shell (USCS) Au38.4@Au4.1Pt57.5 nanoparticles (NPs) with an optimal Pt-to-Au ratio were successfully prepared by the optimal etching treatment of USCS Au@AuPt NPs by Fe(III) ions to remove some exposed Au atoms on their outermost surfaces. The as-prepared USCS Au38.4@Au4.1Pt57.5 NPs with Fe(III)-etching treatment for 2 h loaded on carbon black as catalysts (USCS2h Au38.4@Au4.1Pt57.5-NP/C catalysts) exhibit superior electrocatalytic activity and durability for both the hydrogen evolution reaction (HER) and oxygen reduction reaction (ORR) in acidic media. For instance, the overpotential of USCS2h Au38.4@Au4.1Pt57.5-NP/C catalysts toward the HER is 13 mV at a current density of -10 mA cm-2 (η10 = 13 mV), which is much better than that of commercial Pt/C catalysts (η10 = 31 mV). Moreover, their mass activity (63.8 A mgPt-1) is about 16.4 times larger than that of commercial Pt/C catalysts (3.9 A mgPt-1). In addition, they also present better long-term stability. Furthermore, they also show an improved activity toward the ORR in terms of the half-wave potential (E1/2) (0.89 V vs. RHE), which is more positive by about 38 mV than commercial Pt/C catalysts (0.852 V). In addition, they also show a higher kinetic current density (14.22 mA cm-2 at 0.85 V) and better long-term durability. This etching-treatment strategy can be extended to further improve the catalytic performance of ultra-small Au-based bimetallic or multi-metallic NPs by surface engineering.

4.
Zhongguo Dang Dai Er Ke Za Zhi ; 25(1): 51-59, 2023 Jan 15.
Artigo em Chinês | MEDLINE | ID: mdl-36655664

RESUMO

OBJECTIVES: To study the efficacy and safety of rituximab combined with chemotherapy in the treatment of children and adolescents with mature B-cell non-Hodgkin's lymphoma (B-NHL) through a Meta analysis. METHODS: The databases including PubMed, Embase, the Cochrane Library, ClinicalTrials.gov, Web of Science, China National Knowledge Infrastructure, Wanfang Data, and Weipu were searched to obtain 10 articles on rituximab in the treatment of mature B-NHL in children and adolescents published up to June 2022, with 886 children in total. With 3-year event-free survival (EFS) rate, 3-year overall survival (OS) rate, complete remission rate, mortality rate, and incidence rate of adverse reactions as outcome measures, RevMan 5.4 software was used for Meta analysis, subgroup analysis, sensitivity analysis, and publication bias analysis. RESULTS: The rituximab+chemotherapy group showed significant increases in the 3-year EFS rate (HR=0.38, 95%CI: 0.25-0.59, P<0.001), 3-year OS rate (HR=0.29, 95%CI: 0.14-0.61, P=0.001), and complete remission rate (OR=3.72, 95%CI: 1.89-7.33, P<0.001) as well as a significant reduction in the mortality rate (OR=0.31, 95%CI: 0.17-0.57, P<0.001), as compared with the chemotherapy group without rituximab. There was no significant difference in the incidence rate of adverse reactions between the two groups (OR=1.28, 95%CI: 0.85-1.92, P=0.24). CONCLUSIONS: The addition of rituximab to the treatment regimen for children and adolescents with mature B-cell non-Hodgkin's lymphoma can bring significant survival benefits without increasing the incidence of adverse reactions.


Assuntos
Linfoma de Células B , Criança , Adolescente , Humanos , Rituximab/efeitos adversos , Linfoma de Células B/tratamento farmacológico , Intervalo Livre de Progressão , Indução de Remissão , China , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
5.
Conserv Biol ; 2023 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-36661061

RESUMO

Climate warming can substantially impact embryonic development and juvenile growth in oviparous species. Estimating the overall impacts of climate warming on oviparous reproduction is difficult because egg-laying events happen throughout the reproductive season. Successful egg-laying requires the completion of embryonic development as well as hatching timing conducive to offspring survival and energy accumulation. We propose a new metric - egg-laying opportunity (EO) - to estimate the annual hours during which a clutch of freshly laid eggs yields surviving offspring that store sufficient energy for overwintering. We estimated the EO within the distribution of a model species, Sceloporus undulatus, under recent climate condition and a climate-warming scenario by combining microclimate data, developmental functions, and biophysical models. We predicted that EO will decline as the climate warms at 74.8% of 11407 sites. Decreasing hatching success and offspring energy accounted for more lost EO hours (72.6% and 72.9%) than the occurrence of offspring heat stress (59.9%). Nesting deeper (at a depth of 12 cm) may be a more effective behavioral adjustment for retaining EO than using shadier (50% shade) nests because the former fully mitigated the decline of EO under the considered warming scenario at more sites (66.1%) than the latter (28.3%). We advocate for the use of EO in predicting the impacts of climate warming on oviparous animals because it encapsulates the integrative impacts of climate warming on all stages of reproductive life-history. This article is protected by copyright. All rights reserved.


摘要 气候变暖可能严重影响卵生物种的胚胎发育和幼体生长。由于产卵事件先后发生在整个繁殖季节, 评估气候变暖对卵生物种繁殖的总体影响十分困难。一次成功的产卵除了让胚胎能够完成发育外, 还需要让卵在有利于后代生存和能量积累的时机孵化。我们提出了一个新的指标--产卵机会(EO) --用来估计一年中一窝新产卵能够产生成功越冬后代的时间。结合微气候数据、胚胎发育数据和生物物理模型, 我们估算了模式物种东部强棱蜥(Sceloporus undulatus)在当前气候条件和气候变暖情景下, 其分布范围内的EO。我们预测, 在东部强棱蜥分布区内的11407个位点中, 74.8%的位点的EO将随着气候变暖而缩短。由孵化成功率降低和后代能量积累减少所造成的EO损失(72.6%和72.9%)大于由新生幼体热压力所造成的EO损失(59.9%)。在气候变暖情景下, 增加产卵巢穴深度(12 cm)可能比在更郁闭的巢穴中产卵(50%郁闭)更有效地减缓EO损失, 因为在东部强棱蜥的例子中前者(66.1%)比后者(28.3%)在更多的地点避免了EO的损失。我们提倡使用EO来预测气候变暖对卵生动物的影响, 因为它概括了气候变暖对繁殖生活史各个阶段的综合影响。.

6.
Biomacromolecules ; 2023 Jan 21.
Artigo em Inglês | MEDLINE | ID: mdl-36680518

RESUMO

As a highly crystalline and renewable natural polymer nanomaterial, chitin nanocrystals (ChNCs) have attracted intense interest in the biomedical field. The structure of a ChNC is composed of an acetylglucosamine unit containing two hydroxyl groups and an acetyl group. The acetyl group can be converted to the active amino group through deacetylation, which is under the condition of maintaining the rod-like morphology and high crystalline property and is beneficial for the following modification and potential application. We investigated the relationship between different treatments and varied crystallinities of the modified ChNC, which obtained surface amino groups and aldehyde groups and retained high crystallinity. The natural biomolecules were covalently immobilized on the surface of the ChNC. The etherification was performed based on the hydroxyl groups. Based on the amino groups and the aldehyde groups, the carboxyamine and Knoevenagel condensation reactions were realized on ChNCs. Finally, natural biomolecule-modified ChNCs showed no or low cytotoxicity, antibacterial properties, and high antioxidant properties, which extended their potential biomedical applications.

7.
Sci Total Environ ; : 161693, 2023 Jan 18.
Artigo em Inglês | MEDLINE | ID: mdl-36681340

RESUMO

Recently, p-nitrophenol (PNP), a common organic environmental pollutant, has been reported to be degraded by biochar. Although the degradation mechanism of PNP by biochar has been explored, the role of biochar-derived dissolved organic matter (BDOM) in PNP degradation remains unclear. Two BDOM samples were prepared in this study, and their PNP degradation performance was analyzed. BDOM5 (prepared at 500 °C) exhibited higher PNP degradation ratio than BDOM7 (prepared at 700 °C). The extent of PNP degradation per unit of BDOM5 and BDOM7 reached 9.54 and 4.19 mg/mg, respectively. Gas chromatography-mass spectrometry (GC-MS) analysis showed that both oxidative and reductive processes contributed to the PNP degradation by BDOM. Compared with BDOM7, the higher PNP removal of BDOM5 was due to the higher electron exchange capacity. Furthermore, hydroxyl radicals (OH) played a critical role in the oxidative degradation process of PNP by BDOM. This study sheds light on the phenomenon of PNP degradation by BDOM and these results may be useful for accurately assessing the environmental impact of biochar application.

8.
Angew Chem Int Ed Engl ; : e202216083, 2023 Jan 03.
Artigo em Inglês | MEDLINE | ID: mdl-36594790

RESUMO

The electro-reforming of glycerol is an emerging technology of simultaneous hydrogen production and biomass valorization. However, its complex reaction network and limited catalyst tunability restrict the precise steering toward high selectivity. Herein, we incorporated the chelating phenanthrolines into the bulk nickel hydroxide and tuned the electronic properties by installing functional groups, yielding tunable selectivity toward formate (max 92.7 %) and oxalate (max 45.3 %) with almost linear correlation with the Hammett parameters. Further combinatory study of intermediate analysis and various spectroscopic techniques revealed the electronic effect of tailoring the valence band that balances between C-C cleavage and oxidation through the key glycolaldehyde intermediate. A two-electrode electro-reforming setup using the 5-nitro-1,10-phenanthroline-nickel hydroxide catalyst was further established to convert crude glycerol into pure H2 and isolable sodium oxalate with high efficiency.

9.
Adv Drug Deliv Rev ; : 114710, 2023 Jan 25.
Artigo em Inglês | MEDLINE | ID: mdl-36708774

RESUMO

Plasmonic nanoparticles and their assemblies have been widely used in biosensing, optical imaging, and biomedicine over the past few decades. Especially in the field of radiotherapy, the physicochemical properties of high-Z plasmonic nanomaterials endow them with the ability to sensitize radiotherapy. Compared with single particles, the assembled structure with tunable properties leads to versatile applications in drug delivery and cancer treatment. In this review, we focus on plasmonic nanoparticles and their assemblies for cancer radiotherapy. First, the sensitization mechanism of plasmonic radiosensitizers is briefly introduced. Subsequently, the recent progress in cancer radiotherapy is systematically discussed according to the structure and shape classification. Finally, the current challenges and future perspectives in this field are also discussed in detail.

10.
J Hazard Mater ; 446: 130715, 2023 03 15.
Artigo em Inglês | MEDLINE | ID: mdl-36603418

RESUMO

Neonicotinoids (NEOs) are widely applied in agricultural lands and are widespread in different environments, accelerating threats to ecosystems and human health. A number of in vitro/in vivo studies have reported adverse effects of NEOs on mammalian health, but the link between NEO exposure and toxic effects on human liver remains unclear. We randomly recruited 201 participants and quantified eight commercialized NEOs in bile. High frequency and concentration of detection indicate low degradation of human liver on NEOs. The main NEOs are nitenpyram and dinotefuran, which contribute to about 86% of the total residual levels of eight NEOs, due to the highest solubility in bile and are not degraded easily in liver. In contrast, imidacloprid and thiacloprid are major compounds in human blood, according to previous studies, suggesting that individual NEOs behave differently in blood and bile distribution. There was no statistical difference in NEO residues between cancer and non-cancer participants and among the different participant demographics (e.g., age, gender, and body mass index). The serum hematological parameters -bile acid, total bilirubin, cholesterol and alkaline phosphatase -were positively correlated with individual NEO concentrations, suggesting that NEO exposure affects liver metabolism and even enterohepatic circulation. The study first examined the NEO residues in human bile and provided new insights into their bioavailability and hepatoxicity risk.


Assuntos
Doença Hepática Induzida por Substâncias e Drogas , Inseticidas , Animais , Humanos , Inseticidas/toxicidade , Inseticidas/análise , Bile/química , Ecossistema , Neonicotinoides/toxicidade , Nitrocompostos , Mamíferos
11.
Biomaterials ; 294: 122000, 2023 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-36640541

RESUMO

Cell nucleus is the desired subcellular organelle of many therapeutic drugs. Although numerous nanomaterial-based methods have been developed which could facilitate nuclear-targeted delivery of small-molecule drugs, few are known to be capable of delivering exogenous native proteins. Herein, we report a convenient and highly robust approach for effective nuclear-targeted delivery of native proteins/antibodies by using biodegradable silica nanocapsules (BSNPs) that were surface-modified with different nuclear localization signals (NLS) peptides. We found that, upon gaining entry to mammalian cells via endocytosis, such nanocapsules (protein@BSNP-NLS) could effectively escape from endolysosomal vesicles with the assistance of an endosomolytic peptide (i.e., L17E), accumulate in cell nuclei and release the encapsulated protein cargo with biological activities. Cloaked with HeLa cell membrane, DNase@BSNP-NLS/L17E-M (with L17E encapsulated) homologously delivered functional proteins to cancer cell nuclei in tumor-xenografted mice. In vitro and in vivo anti-tumor properties, such as long blood circulation time and effective tumor growth inhibition, indicate that the nuclear-targeted cell-membrane-cloaked BSNPs (DNase@BSNP-NLS/L17E-M) platform is a promising therapeutic approach to nuclear related diseases.

12.
Neural Regen Res ; 18(7): 1601-1606, 2023 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-36571368

RESUMO

Studies have shown that phosphatase and tensin homolog deleted on chromosome ten (PTEN) participates in the regulation of cochlear hair cell survival. Bisperoxovanadium protects against neurodegeneration by inhibiting PTEN expression. However, whether bisperoxovanadium can protect against noise-induced hearing loss and the underlying mechanism remains unclear. In this study, we established a mouse model of noise-induced hearing loss by exposure to 105 dB sound for 2 hours. We found that PTEN expression was increased in the organ of Corti, including outer hair cells, inner hair cells, and lateral wall tissues. Intraperitoneal administration of bisperoxovanadium decreased the auditory threshold and the loss of cochlear hair cells and inner hair cell ribbons. In addition, noise exposure decreased p-PI3K and p-Akt levels. Bisperoxovanadium preconditioning or PTEN knockdown upregulated the activity of PI3K-Akt. Bisperoxovanadium also prevented H2O2-induced hair cell death by reducing mitochondrial reactive oxygen species generation in cochlear explants. These findings suggest that bisperoxovanadium reduces noise-induced hearing injury and reduces cochlear hair cell loss.

13.
J Environ Sci (China) ; 126: 754-760, 2023 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-36503800

RESUMO

To investigate the impact of emission controls on ammonia (NH3) pollution in urban atmosphere, observation on NH3 (1 hr interval) was performed in Shanghai before, during and after the 2019 China International Import Expo (CIIE) event, along with measurements on inorganic ions, organic tracers and stable nitrogen isotope compositions of ammonium in PM2.5. NH3 during the CIIE period was 6.5±1.0 µg/m3, which is 41% and 32% lower than that before and after the event, respectively. Such a decrease was largely ascribed to the emission controls in nonagricultural sources, of which contribution for measured NH3 in control phase abated by ∼20% compared to that during uncontrol period. Molecular compositions of PAHs and hopanes further suggested a dominant role of the reduced vehicle emissions in the urban NH3 abatement during the CIIE period. Our results revealed that vehicle exhaust emission control is an effective way to mitigate NH3 pollution and improve air quality in Chinese urban areas.


Assuntos
Amônia , Emissões de Veículos , China , Atmosfera , Poluição Ambiental
14.
ACS Appl Mater Interfaces ; 15(1): 1583-1591, 2023 Jan 11.
Artigo em Inglês | MEDLINE | ID: mdl-36537368

RESUMO

Two-dimensional semiconducting transition-metal dichalcogenides (TMDCs) have attracted extensive attention as building blocks of miniaturized electronic and optical devices. However, as the characteristics of TMDC devices are predominately determined by their device structures, the function of TMDC devices is fixed once fabricated, leaving the reconfigurable active device and circuit a challenge. Here, we have demonstrated the current rectification switching in TMDC vertical diodes using a liquid metal (EGaIn) top electrode with a reconfigurable contact area. The rectification switching is closely related to the ultrathin gallium oxide layer on the surface of EGaIn. Under the small contact, with the existence of gallium oxide, photocurrent dominates the electrical transport showing a negative rectification, while as the contact increases, the broken gallium oxide leads to rectification switching to the positive bias direction. Such rectification switching applies to thin TMDC flakes down to 3 nm, benefitting from the soft electrical contact between the TMDC and the EGaIn electrode. Our work shows the new possibility of actively reconfigurable TMDC vertical diodes enabled by the liquid metal electrode and will promote promising applications of flexible and tunable TMDC-based nanoelectronic devices.

15.
Org Lett ; 25(4): 576-580, 2023 Feb 03.
Artigo em Inglês | MEDLINE | ID: mdl-36475779

RESUMO

A relay catalytic protocol using pyrrolidine and palladium catalysis has been developed for asymmetric synthesis of 1,3-diamine derivatives from 3-substituted 1,3-dienes, sulfuric diamide, and aldehydes. This one-pot, three-component reaction features the advantages of a high atom step economy and operational simplicity, providing an efficient and straightforward access to valuable 1,3-diamines incorporating quaternary and tertiary stereogenic centers with moderate to good enantioselectivity.

16.
Respir Med ; 205: 107042, 2022 Nov 14.
Artigo em Inglês | MEDLINE | ID: mdl-36462288

RESUMO

BACKGROUND: This study provides a comprehensive, comparative and updated estimates of temporal patterns of lower respiratory infections (LRIs) globally over the past three decades. METHODS: The data on morbidity and mortality of patients with LRIs at the global, regional and national levels were retrieved from the Global Burden of Disease (GBD) 2019 study. RESULTS: Globally, the incident cases of LRIs increased from 414,342,866 [95% uncertainty interval (UI):383,529,625 to 449, 086,938]in 1990 to 488,902,504(95% UI: 457,572,987 to 522,635,542)in 2019 with the age standardized incidence rate (ASIR) decreased from 8,276/100,000 persons (95% UI: 7,727 to 8,892) to 6,295/100,000 persons (95% UI: 5,887 to 6,737) between 1990 and 2019. Number of LRIs deaths were 2,493,200 (95% UI: 2,268,184 to 2,736,184) in 2019, a decrease of 24.9% (95% UI: -34.4 to -15.4) in the past 30 years. Meanwhile, the age-standardized death rate (ASDR) declined also from 67/100,000 persons (95% UI: 61 to 73) in 1990 to 34/100,000 persons (95% UI: 31 to 38) in 2019. Moreover, the numbers and age-standardized rates per 100,000 persons of morbidity and mortality varied widely by age, sex, Socio-Demographic Index (SDI) quintiles, and geographical locations in 2019. CONCLUSION: LRIs remain a major public health concern . Some differences in age, sex, SDI quintiles, and geographical locations contribute to LRIs-related global health policy development and health system resource optimization.

17.
ACS Omega ; 7(47): 43102-43110, 2022 Nov 29.
Artigo em Inglês | MEDLINE | ID: mdl-36467952

RESUMO

Recovery of phosphate (P) from sludge, domestic wastewater, and industrial wastewater is beneficial for overcoming the problem of shortage of P rock resources. In this study, Mg-functionalized peanut shell-derived biochar was prepared by ultrasound-assisted impregnation. The obtained Mg-laden biochar had a higher content of Mg, a larger specific surface area, and more porosity. The prepared Mg-modified biochar exhibited excellent adsorption properties of phosphorus. Modified biochar has a higher amount of adsorbed P than raw biochar. The capacity of P adsorption by modified biochar was 30.48-114.24% higher than that by raw biochar. Moreover, the Mg-laden biochar can be applied in a wide working environment (pH: 2-10; temperature range: 15-40 °C). This study not only develops a new strategy for the preparation of high-capacity P adsorbents but also provides a new green use for agricultural peanut shells.

18.
J Am Chem Soc ; 2022 Dec 05.
Artigo em Inglês | MEDLINE | ID: mdl-36468863

RESUMO

Carboxylic acids are not readily applied as carbon-based nucleophiles due to their intrinsic acidic group. Here, we demonstrate that free (E,E)-2,4-dienoic acids form electron-neutral and highest occupied molecular orbital-raised η2-complexes with Pd(0) and undergo Friedel-Crafts-type additions to imines with exclusive α-regioselectivity, giving formal dienylated products after decarboxylation. Unusual and switchable (E,E)- and (Z,E)-selectivity, along with excellent enantioselectivity, is achieved via ligand-controlled outer-sphere or inner-sphere reaction modes, respectively, which are well supported by comprehensive density functional theory calculation studies. An unprecedented formal reductive Mannich reaction between (E,E)-dienoic acids and imines is also developed to furnish enantioenriched ß-amino acid derivatives.

19.
Artigo em Inglês | MEDLINE | ID: mdl-36469082

RESUMO

PURPOSE: To explore the clinical and radiological effects of the free vascularized iliac bone flap (FVIBF) based on deep iliac circumflex vessels for Association Research Circulation Osseous (ARCO) stage 3 traumatic osteonecrosis of the femoral head (TONFH) in young adults. METHODS: From February 2017 to August 2020, a total of 29 (29 hips) TONFH patients with ARCO stage 3 were enrolled in this study. Following the FVIBF standard procedure, the necrotic area of the femoral head was removed and a free vascularized iliac bone flap was harvested and grafted. X-rays were performed at 1, 3, 6, 9, and 12 months and every 6 months thereafter postoperatively for evaluation of the degree of femoral head collapse. The Beijing University of Chinese Medicine X-ray Evaluation Method (BUCMXE) was used to evaluate the hip preservation effects based on anteroposterior hip radiographs. Hip functions were evaluated using the Harris hip score (HHS) every 6 months and annually after 24 months, and the quality of life was assessed using the SF-36 questionnaire at 18 months postoperatively. RESULTS: The mean follow-up time was 30 months (range 12-54 months). None of the patients was lost to follow-up, and the wounds healed primarily without infection and deep venous thrombosis of lower limbs. The HHS at 12 months postoperatively was significantly improved than that before surgery (83.4 ± 7.4 vs. 64.8 ± 14.1; p < 0.05). The BUCMXE radiographic score at 12 months postoperatively did not reveal any significant differences in femoral head morphology and osteonecrotic lesion, when compared to preoperation. The SF-36 questionnaire showed significant improvements in social functioning, role physical, bodily pain, and general health (p < 0.05). However, eight patients had varying degrees of femoral head collapse after surgery, and only one of them underwent THA due to pain and collapse aggravation. BUCMXE-Osteoarthritis scores showed that 23 hips were stable and six hips were advanced, among which five hips staged ARCO 3B and one staged ARCO 3A preoperatively, with statistically significant differences (p < 0.05). CONCLUSION: Although some patients showed no improvement of radiological outcomes, most patients with severe TONFH could still benefit from the FVIBF procedure. Further studies should attempt to improve this surgical procedure and explore its long-term efficacy.

20.
BMC Ophthalmol ; 22(1): 512, 2022 Dec 28.
Artigo em Inglês | MEDLINE | ID: mdl-36578031

RESUMO

BACKGROUND: To ascertain the agreement of corneal aberrations obtained from the Pentacam and the KR-1W in myopic populations and to investigate the influence of the level of myopia as well as the laterality on the agreement. METHODS: In this observational study, a rotating Scheimpflug camera (Pentacam AXL) and a Hartmann-Shack wavefront analyzer with Placido-disc topographer (KR-1W) were used to measure the aberrations of myopes in the anterior corneal surface by one experienced operator. All examinations were computed across a 6 mm diameter. Six subgroups were generated according to the degree of myopia (mild, moderate, and severe myopia) and the laterality of eyes (right and left eyes). RESULTS: The study included 245 eyes of 170 participants. For certain anterior corneal aberrations, statistically significant differences existed between the Pentacam and the KR-1W (all P < .05). The values of Zernike (Z)(2,0), Z(2,2), Z(3,1), and Z(4,0) varied in all levels of myopia regardless of the laterality, with the values of the Pentacam constantly larger than the KR-1W in the measurement of Z(2,0), Z(2,2), and Z(4,0). For 2nd to 6th aberrations, both instruments correlated poorly to moderately. The width of limits of agreement between the two instruments was clinically too wide (> 0.1 µm) for aberrations closely correlated with visual quality, including Z(3, ± 3), Z(3, ± 1), and Z(4,0), and almost all aberrations, indicating poor agreement. CONCLUSIONS: In clinical practice, the Pentacam based on Scheimpflug technology and the KR-1W based on Placido Disc System are not interchangeable in measuring anterior corneal aberration for myopes regardless of myopia degree and the laterality, suggesting that a consistent instrument should be selected for surgical design as well as follow-up.


Assuntos
Aberrações de Frente de Onda da Córnea , Miopia , Humanos , Topografia da Córnea , Aberrações de Frente de Onda da Córnea/diagnóstico , Córnea/diagnóstico por imagem , Miopia/diagnóstico
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