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1.
J Hazard Mater ; 421: 126800, 2022 Jan 05.
Artigo em Inglês | MEDLINE | ID: mdl-34396955

RESUMO

In order to promote the application of membrane technology in the treatment of textile wastewater containing small molecule dye, fabricating a hollow fiber loose nanofiltration (LNF) with a thin and compact separation layer and deepening the understanding of compactness-tailoring mechanism in chemical crosslinking are essential. Firstly, the mechanisms of synergistic crosslinking of PEI-70K and PEI-10K, along with a weakening of the PEI hydration by ethanol, were expounded in primary crosslinking. Then, some LNF separation layers with different compactness were prepared through crosslinking with different crosslinkers to further reduce pore size, which resulted in the efficient removal (~100%) of a small molecular dye (methyl orange (MO), M = 327 g mol-1). The removal of methyl orange is mainly caused by size sieving. The relationship among the pore size, the Mw of the secondary crosslinkers, and the pore size reduction rate was interpreted by comparing the pore size reduction rate of three secondary crosslinkers with different molecular weights. In addition, the as-prepared separation layer exhibited excellent dimensional stability and solvent resistance. This paper not only provides a reference for fabricating hollow fiber LNF with better purification performance, but also shows their potential in developing solvent resistant nanofiltration.

3.
J Am Chem Soc ; 2021 Oct 12.
Artigo em Inglês | MEDLINE | ID: mdl-34641670

RESUMO

The surface of an electrocatalyst undergoes dynamic chemical and structural transformations under electrochemical operating conditions. There is a dynamic exchange of metal cations between the electrocatalyst and electrolyte. Understanding how iron in the electrolyte gets incorporated in the nickel hydroxide electrocatalyst is critical for pinpointing the roles of Fe during water oxidation. Here, we report that iron incorporation and oxygen evolution reaction (OER) are highly coupled, especially at high working potentials. The iron incorporation rate is much higher at OER potentials than that at the OER dormant state (low potentials). At OER potentials, iron incorporation favors electrochemically more reactive edge sites, as visualized by synchrotron X-ray fluorescence microscopy. Using X-ray absorption spectroscopy and density functional theory calculations, we show that Fe incorporation can suppress the oxidation of Ni and enhance the Ni reducibility, leading to improved OER catalytic activity. Our findings provide a holistic approach to understanding and tailoring Fe incorporation dynamics across the electrocatalyst-electrolyte interface, thus controlling catalytic processes.

4.
Pediatr Infect Dis J ; 2021 Sep 09.
Artigo em Inglês | MEDLINE | ID: mdl-34508026

RESUMO

BACKGROUND: China has a high burden of tuberculosis and latent tuberculosis infection (LTBI). The aim of this study was to estimate the prevalence of LTBI among healthy young children and adolescents and test a 2-step approach to explore the threshold for the diagnosis of tuberculosis infection in Chengdu, China. METHODS: Healthy preschool children and school-going children in Chengdu, Sichuan Province, were screened for LTBI using the tuberculin skin test (TST). Preschool children with TST ≥ 5 mm also underwent interferon-γ release assay (IGRA) to explore the threshold of this 2-step approach. RESULTS: In total, 5667 healthy young children and adolescents completed TST test between July 2020 and January 2021 and were included in the present analysis. The age of the participants ranged from 2.4 to 18 years (median 7.25 ± 4.514 years), of which 2093 (36.9%) were younger than 5 years. The overall prevalence of LTBI was 6.37% and 6.64% in children younger than 5 years old. Fourteen of the 341 preschool children with TST ≥5 mm were interferon-γ release assay positive, of which 4 showed a TST result of 5-10 mm, and 6 preschool children received preventive treatment for LTBI. CONCLUSIONS: Healthy young children and adolescents should also be considered as important target populations for LTBI screening. TST can be recommended for first-line screening as part of a 2-step approach for LTBI screening using a positive threshold of 5 mm.

5.
Med Sci Monit ; 27: e931471, 2021 Aug 27.
Artigo em Inglês | MEDLINE | ID: mdl-34446688

RESUMO

BACKGROUND The demand for plasma and plasma products has increased in China, which has a short supply. Compared with whole blood donors, plasma donors and their donation behavior have received less attention. This study aimed to investigate the demographic characteristics and lifestyle habits of Chinese plasma donors. MATERIAL AND METHODS During 2018-2019, information on plasma donors was collected from blood product companies using a 25-item questionnaire, including sex, age, height, weight, blood group, donation frequency, occupation, smoking and drinking, and sleeping and dietary habits. RESULTS Among 15 497 plasma donors, 70.5% were women and 78.5% were aged 46-55 years. Among 4847 plasma donors, the average height of men was 169.5±6.2 cm and the average height of women was 157.0±4.6 cm. In addition, the average weight of men was 67.0±10.4 kg and the average weight of women was 60.0±8.3 kg. The prevalence of obesity (body mass index ≥30.0 kg/m²) of all donors was 14.8%; 14.7% of men were obese, and 15% of women were obese. Among all plasma donors, 88.8% were farmers and 60% were frequent donors with a donation history of at least 5 years. Among all donors, 84.0% did not smoke, 67.3% did not drink, and 95.1% reported good sleep quality. All respondents reported healthy dietary habits. CONCLUSIONS Healthy lifestyle habits considerably affect the health of plasma donors and the quality of source plasma. Chinese plasma donors in this study demonstrated imbalances in terms of characteristics, which became more marked with age.


Assuntos
Consumo de Bebidas Alcoólicas/epidemiologia , Doadores de Sangue/estatística & dados numéricos , Índice de Massa Corporal , Comportamento Alimentar , Estilo de Vida , Fumar/epidemiologia , Adolescente , Adulto , China/epidemiologia , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Adulto Jovem
6.
Hematology ; 26(1): 503-509, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34238131

RESUMO

OBJECTIVE: High altitude (HA), with the main feature of hypobaric hypoxia, is an independent risk factor for thrombosis. However, little is known on the alterations of fibrinolytic system in adaptation to HA. In this study, we investigated changes of fibrinolytic system parameters between individuals permanently living at HA and low altitude (LA) regions, and provided data for further studies on HA-induced thrombotic disease. MATERIAL AND METHODS: A total of 226 eligible participants, including 103 LA participants, 100 healthy HA subjects and 23 high altitude polycythemia (HAPC) patients, were recruited in this study. Six fibrinolytic parameters, i.e. fibrinogen (Fbg), D-dimer (DDi), antithrombin III (AT-III), plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (tPA) and plasminogen (PLG) were analyzed respectively. PAI-1 and tPA were performed by using bio-immuno-assays and an automated coagulation analyzer was used to conduct Fbg, DDi, AT-III and PLG tests. RESULTS: Plasma levels of Fbg, DDi, PAI-1 and PLG were significantly higher in healthy HA group than in LA group (all p < 0.05), whereas tPA was significantly lower in healthy HA group. No significant difference in AT-III was observed between healthy HA and LA groups (p > 0.05). All these fibrinolytic parameters showed no significant distinctions between healthy HA subjects and HAPC patients (all p > 0.05). HGB showed no relationship with fibrinolytic parameters in HA cohort. CONCLUSION: This study demonstrates that HA environment has a significant effect on fibrinolytic system and provides a foundation for further studies on HA hypobaric hypoxia-induced thrombotic disease.


Assuntos
Altitude , Fibrinólise , Trombose/etiologia , Adulto , Idoso , Antitrombina III/análise , Feminino , Produtos de Degradação da Fibrina e do Fibrinogênio/análise , Fibrinogênio/análise , Humanos , Masculino , Pessoa de Meia-Idade , Trombose/sangue , Adulto Jovem
7.
Microbiol Mol Biol Rev ; 85(3): e0022020, 2021 08 18.
Artigo em Inglês | MEDLINE | ID: mdl-34319143

RESUMO

True morels (Morchella spp., Morchellaceae, Ascomycota) are widely regarded as a highly prized delicacy and are of great economic and scientific value. Recently, the rapid development of cultivation technology and expansion of areas for artificial morel cultivation have propelled morel research into a hot topic. Many studies have been conducted in various aspects of morel biology, but despite this, cultivation sites still frequently report failure to fruit or only low production of fruiting bodies. Key problems include the gap between cultivation practices and basic knowledge of morel biology. In this review, in an effort to highlight the mating systems, evolution, and life cycle of morels, we summarize the current state of knowledge of morel sexual reproduction, the structure and evolution of mating-type genes, the sexual process itself, and the influence of mating-type genes on the asexual stages and conidium production. Understanding of these processes is critical for improving technology for the cultivation of morels and for scaling up their commercial production. Morel species may well be good candidates as model species for improving sexual development research in ascomycetes in the future.


Assuntos
Ascomicetos/genética , Ascomicetos/fisiologia , Animais , DNA Fúngico/genética , Evolução Molecular , Estágios do Ciclo de Vida/genética , Estágios do Ciclo de Vida/fisiologia
8.
Pharm Biol ; 59(1): 757-768, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34144662

RESUMO

CONTEXT: Relinqing granules (RLQ) are being used alone or in combination with antibacterial drugs to treat urological disorders. OBJECTIVE: This study investigates the pharmacokinetics of RLQ in humans and the potential for RLQ-perpetrated interactions on transporters. MATERIALS AND METHODS: Twelve healthy subjects (six women and six men) participated to compare single- and multiple-dose pharmacokinetics of RLQ. In the single-dose study, all 12 subjects received 8 g of RLQ orally. After a 7-d washout period, the subjects received 8 g of RLQ for seven consecutive days (t.i.d.) and then a single dose. Gallic acid (GA) and protocatechuic acid (PCA) in plasma and urine samples were analysed using LC-MS/MS. The transfected cells were used to study the inhibitory effect of GA (50-5000 µg/L) and PCA (10-1000 µg/L) on transporters OAT1, OAT3, OCT2, OATP1B1, P-gp and BCRP. RESULTS: GA and PCA were absorbed into the blood within 1 h after administration and rapidly eliminated with a half-life of less than 2 h. The mean peak concentrations of GA (102 and 176 µg/L) and PCA (4.54 and 7.58 µg/L) were lower in males than females, respectively. The 24 h urine recovery rates of GA and PCA were about 10% and 5%, respectively. The steady-state was reached in 7 d without accumulation. GA was a potent inhibitor of OAT1 (IC50 = 3.73 µM) and OAT3 (IC50 = 29.41 µM), but not OCT2, OATP1B1, P-gp or BCRP. DISCUSSION AND CONCLUSIONS: GA and PCA are recommended as PK-markers in RLQ-related pharmacokinetic and drug interaction studies. We should pay more attention to the potential for RLQ-perpetrated interactions on transporters.

9.
Food Funct ; 12(13): 5850-5861, 2021 Jul 05.
Artigo em Inglês | MEDLINE | ID: mdl-34018523

RESUMO

Nuciferine (NF) has received extensive attention due to its medicinal value in the treatment of metabolic diseases, such as obesity; however, to date, the effects of NF on obesity-related intestinal permeability, autophagy and the gut microbiota have not been investigated. Herein, C57BL/6J mice were fed either a chow or a high-fat diet (HFD) with or without NF for 8 weeks. The results showed that NF supplement reduced weight gain, fat accumulation and intestinal permeability in the HFD mice accompanied by improved autophagy. Subsequently, an in vitro experiment was performed using Caco-2 and HT-29 cells, which showed that NF supplement not only promoted the formation of autophagosomes and autophagolysosomes, but also alleviated LPS-increased intestinal permeability. Importantly, NF supplement protected from LPS-induced paracellular permeability impairment after the administration of autophagy-related gene (Atg) 5 small-interfering RNA (siRNA). These results demonstrate that NF exerts beneficial effects on the intestinal permeability by improving autophagy. Furthermore, we also found that NF supplement lowered the abundance of Butyricimonas and increased the abundance of Akkermansia, an anti-obesity bacterium. Thus, overall, we demonstrated that NF supplement confers reduced intestinal permeability by improving autophagy and alters the composition of the gut microbiota in HFD-fed mice, thereby producing an anti-obesity effect.

10.
Endocrine ; 73(1): 71-84, 2021 07.
Artigo em Inglês | MEDLINE | ID: mdl-33905112

RESUMO

AIMS: Investigations show that 30-40% of patients with diabetes develop diabetic nephropathy (DN). The gut microbiome has become lively field research in diabetes mellitus and chronic kidney disease. The gut microbial profile in DN (stage-3 or 4) patients and healthy controls were systematically analyzed, the discrepancies on microbial profiles in different disease stages, gender, and BMI in DN were also described. METHODS: Fecal samples from 37 healthy volunteers (HG) and 43 DN patients (PG) were recruited to gut microbiota 16S rDNA V3-V4 regions analysis. In consideration of disease stage, gender, and BMI, PG, and HG were further divided into three subgroups. To predict the DN stage, a random forest model was carried out, using the most discrepant genera selected from the PG and HG samples. RESULTS: Gut bacterial richness and diversity in PG were far less than HG. The gut microbiota composition in PG-III was at the middle level between HG and PG-IV. The gender and BMI had some impact on the gut microbiota profile but the major difference still came from the disease. The random forest model was constructed from 25 most discrepant microbe genera. The area under curve (AUC) of receiving operational curve (ROC) was 0.972, indicated a high discriminatory power to predict DN. CONCLUSIONS: DN patients showed dysbiosis and a decrease in gut bacterial richness and diversity compared with HG. Several characterized genera like Megasphaera, Veillonella, Escherichia-Shigella, Anaerostipes, and Haemophilus might be the new potential microbial biomarkers of DN.


Assuntos
Diabetes Mellitus , Nefropatias Diabéticas , Microbioma Gastrointestinal , Bactérias , Disbiose , Fezes , Humanos
11.
Small ; : e2100203, 2021 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-33856115

RESUMO

Engineering high-performance electrocatalysts is of great importance for energy conversion and storage. As an efficient strategy, element doping has long been adopted to improve catalytic activity, however, it has not been clarified how the valence state of dopant affects the catalytic mechanism and properties. Herein, it is reported that the valence state of a doping element plays a crucial role in improving catalytic performance. Specifically, in the case of iridium doped nickel-iron layer double hydroxide (NiFe-LDH), trivalent iridium ions (Ir3+ ) can boost hydrogen evolution reaction (HER) more efficiently than tetravalent iridium (Ir4+ ) ions. Ir3+ -doped NiFe-LDH delivers an ultralow overpotential (19 mV @ 10 mA cm-2 ) for HER, which is superior to Ir4+ doped NiFe-LDH (44 mV@10 mA cm-2 ) and even commercial Pt/C catalyst (40 mV@ 10 mA cm-2 ), and reaches the highest level ever reported for NiFe-LDH-based catalysts. Theoretical and experimental analyses reveal that Ir3+ ions donate more electrons to their neighboring O atoms than Ir4+ ions, which facilitates the water dissociation and hydrogen desorption, eventually boosting HER. The same valence-state effect is found for Ru and Pt dopants in NiFe-LDH, implying that chemical valence state should be considered as a common factor in modulating catalytic performance.

12.
Fungal Biol ; 125(4): 285-293, 2021 04.
Artigo em Inglês | MEDLINE | ID: mdl-33766307

RESUMO

Morels, fungi from the genus Morchella, are popular edible mushrooms. However, little knowledge of their asexual reproduction and inaccessible pure mitospores hamper illumination of their life cycle. Herein, we successfully induced conidiation, conidial germination and chlamydospore formation in pure culture of Morchella sextelata. Conidiation proceeded via four morphologically distinct stages: development of the conidiophore stalk, stalk branching, phialide differentiation, and conidium production. Terminal and intercalary chlamydospores were formed on conidial hyphae. The development of conidiophores occurred earlier, with more conidia produced, in cross-mating cultures than in single-spore cultures. Mature conidia were spherical and 2.5-8 µm in diameter, with a vast majority (nearly 99%) 2.5-5 µm in diameter. Each conidium contained one to three nuclei (80.2% conidia contained one nucleus, 19.1% contained two nuclei, and 0.7% contained three nuclei). The conidial nucleus diameter was 1-2 µm. The nuclear mitosis in detached conidia that was observed may benefit their colony initiation. Additionally, morel conidia formed conidial anastomosis tubes. Conidia (mitospores) likely not only function as spermatia, but also as reproductive propagules in Morchella. Further research is imperative to elucidate the relationship between the conidia and chlamydospores, and their unique function in the morel life cycle.


Assuntos
Ascomicetos , Reprodução Assexuada , Hifas , Esporos Fúngicos
13.
Appl Microbiol Biotechnol ; 105(7): 2747-2758, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-33686455

RESUMO

The E3 ubiquitin ligase Ubr1 is a core player in yeast ubiquitylation and protein quality control required for cellular events including proteasomal degradation and gene activity but has been rarely explored in filamentous fungi. We show here an essentiality of orthologous Ubr1-mediated ubiquitylation for the activation of central developmental pathway (CPD) and the CPD-controlled cellular events in Beauveria bassiana, a filamentous fungal insect pathogen that undergoes an asexual cycle in vitro or in vivo. As a result of ubr1 disruption, intracellular free ubiquitin accumulation increased by 1.4-fold, indicating an impaired ability for the disruptant to transfer ubiquitin to target proteins. Consequently, the disruptant was compromised in polar growth featured with curved or hook-like germ tubes and abnormally branched hyphae, leading to impeded propagation of aberrant hyphal bodies in infected insect hemocoel and attenuated virulence. In the mutant, sharply repressed expression of three CDP activator genes (brlA, abaA, and wetA) correlated well with severe defects in aerial conidiation and submerged blastospore (hyphal body) production in insect hemolymph or a mimicking medium. Moreover, the disruptant was sensitive to cell wall perturbation or lysing and showed increased catalase activity and resistance to hydrogen peroxide despite null response to high osmolarity or heat shock. Most of the examined genes involved in polar growth and cell wall integrity were down-regulated in the disruptant. These findings uncover that the Ubr1-mediated ubiquitylation orchestrates polar growth and the CDP-regulated asexual cycle in vitro and in vivo in B. bassiana. KEY POINTS: • Ubr1 is an E3 ubiquitin ligase essential for ubiquitylation in Beauveria bassiana. • Ubr1-mediated ubiquitylation is required for activation of central development pathway. • Ubr1 orchestrates polar growth and asexual cycle in vitro and in vivo.


Assuntos
Beauveria , Animais , Beauveria/genética , Beauveria/metabolismo , Proteínas Fúngicas/genética , Proteínas Fúngicas/metabolismo , Esporos Fúngicos/metabolismo , Estresse Fisiológico , Ubiquitinação , Virulência
14.
Zookeys ; 964: 143-159, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32939150

RESUMO

The genus Nagiella was studied using morphological and DNA barcode data. Nagiella bispina sp. nov. is described as a new species, and N. hortulatoides Munroe is recorded in China for the first time. The diagnosis of this genus is revised, and the genitalia description of N. quadrimaculalis (Kollar and Redtenbacher) and N. inferior (Hampson) are given in English for the first time. Nosophora incomitata (Swinhoe) stat. rev. is removed from the synonym of N. quadrimaculalis. Photographs of the habitus and genitalia as well as COI DNA Barcode data of these four species are provided.

15.
Angew Chem Int Ed Engl ; 59(43): 19297-19303, 2020 Oct 19.
Artigo em Inglês | MEDLINE | ID: mdl-32666609

RESUMO

Metallic catalysts with nanopores are advantageous on improving both activity and selectivity, while the reason behind that remains unclear all along. In this work, porous Zn nanoparticles (P-Zn) were adopted as a model catalyst to investigate the catalytic behavior of metallic nanopores. In situ X-ray absorption spectroscopy, in situ Fourier transform infrared spectroscopy, and density functional theory (DFT) analyses reveal that the concave surface of nanopores works like a pincer to capture and clamp CO2 and H2 O precursors simultaneously, thus lowering the energy barriers of CO2 electroreduction. Resultantly, the pincer mechanism endows P-Zn with a high Faradic efficiency (98.1 %) towards CO production at the potential of -0.95 V vs. RHE. Moreover, DFT calculation demonstrates that Co and Cu nanopores exhibit the pincer behavior as well, suggesting that this mechanism is universal for metallic nanopores.

16.
IMA Fungus ; 11: 4, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32617256

RESUMO

Mating-type genes are central to sexual reproduction in ascomycete fungi and result in the establishment of reproductive barriers. Together with hybridization, they both play important roles in the evolution of fungi. Recently, potential hybridization events and MAT genes were separately found in the Elata Clade of Morchella. Herein, we characterized the MAT1-1-1 and MAT1-2-1 genes of twenty-two species in the Esculenta Clade, another main group in the genus Morchella, and proved heterothallism to be the predominant mating strategy among the twenty-two species tested. Ascospores of these species were multi-nuclear and had many mitochondrial nucleoids. The number of ascospore nuclei might be positively related with the species distribution range. Phylogenetic analyses of MAT1-1-1, MAT1-2-1, intergenic spacer (IGS), and partial histone acetyltransferase ELP3 (F1) were performed and compared with the species phylogeny framework derived from the ribosomal internal transcribed spacer region (ITS) and translation elongation factor 1-alpha (EF1-a) to evaluate their species delimitation ability and investigate potential hybridization events. Conflicting topologies among these genes genealogies and the species phylogeny were revealed and hybridization events were detected between several species. Different evolutionary patterns were suggested for MAT genes between the Esculenta and the Elata Clades. Complex evolutionary trajectories of MAT1-1-1, MAT1-2-1, F1 and IGS in the Esculenta Clade were highlighted. These findings contribute to a better understanding of the importance of hybridization and gene transfer in Morchella and especially for the appearance of reproductive modes during its evolutionary process.

17.
Adv Mater ; 32(25): e1908521, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32419191

RESUMO

Water electrolysis in alkaline electrolyte is an attractive way toward clean hydrogen energy via the hydrogen evolution reaction (HER), whereas the sluggish water dissociation impedes the following hydrogen evolution. Noble metal oxides possess promising capability for catalyzing water dissociation and hydrogen evolution; however, they are never utilized for the HER due to the instability under the reductive potential. Here it is shown that compressive strain can stabilize RhO2 clusters and promote their catalytic activity. To this end, a strawberry-like structure with RhO2 clusters embedded in the surface layer of Rh nanoparticles is engineered, in which the incompatibility between the oxide cluster and the metal substrate causes intensive compressive strain. As such, RhO2 clusters remain stable at a reduction potential up to -0.3 V versus reversible hydrogen electrode and present an alkaline HER activity superior to commercial Pt/C.

18.
Ann Transl Med ; 8(7): 490, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32395534

RESUMO

Background: OTU domain-containing protein 3 (OTUD3), as a deubiquitinase (DUB) belonging to the ovarian tumor protease (OTU) family, has been reported to suppress tumor via OTUD3-PTEN signaling axis. Glioma is the most common primary intracranial tumor with high invasiveness and poor prognosis. Although less than half of the patients have phosphatase and tension homologue deleted in chromosome 10 (PTEN) mutations or homozygous deletions, two-thirds of glioma possess diminished PTEN expression. Hence, it is conceivable that other obscure mechanisms may cause the decreased expression of the PTEN protein. Methods: OTUD3 expression was assessed in human normal and glioma tissues at The Cancer Genome Atlas (TCGA) database (https://www.cancer.gov/) and Genotype-Tissue Expression (GTEx) database (https://commonfund.nih.gov/GTex). The mRNA levels of OTUD3 in C6 cells and primary astrocytes were detected using real-time fluorescence quantitative PCR. Western blot was performed to assay PTEN and OTUD3 protein expression in C6 cells and primary astrocytes. By generating Kaplan-Meier curves, we predicted the association between OTUD3 expression and prognosis in glioma patients. Results: (I) OTUD3 transcription was markedly downregulated in glioma based on microarray data for gene expression between human gliomas and normal brain samples. (II) The mRNA levels of OTUD3 in C6 cells was significantly lower than that of in primary astrocytes. (III) The expressions of protein PTEN and OTUD3 in C6 cells were significantly decreased when compared with primary astrocytes. (IV) Glioma patients with high expression of OTUD3 had a longer survival time than patients with low expression. Conclusions: Our present findings demonstrated that low expression of OTUD3 in glioma may be involved in PTEN related glioma and may contribute to patient survival.

19.
Angew Chem Int Ed Engl ; 59(28): 11510-11515, 2020 Jul 06.
Artigo em Inglês | MEDLINE | ID: mdl-32233052

RESUMO

Developing highly efficient and low-cost photocatalysts for overall water splitting has long been a pursuit for converting solar power into clean hydrogen energy. Herein, we demonstrate that a nonstoichiometric nickel-cobalt double hydroxide can achieve overall water splitting by itself upon solar light irradiation, avoiding the consumption of noble-metal co-catalysts. We employed an intensive laser to ablate a NiCo alloy target immersed in alkaline solution, and produced so-called L-NiCo nanosheets with a nonstoichiometric composition and O2- /Co3+ ions exposed on the surface. The nonstoichiometric composition broadens the band gap, while O2- and Co3+ ions boost hydrogen and oxygen evolution, respectively. As such, the photocatalyst achieves a H2 evolution rate of 1.7 µmol h-1 under AM 1.5G sunlight irradiation and an apparent quantum yield (AQE) of 1.38 % at 380 nm.

20.
Adv Mater ; 32(21): e2000482, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32253801

RESUMO

Phase engineering of nanomaterials (PEN) offers a promising route to rationally tune the physicochemical properties of nanomaterials and further enhance their performance in various applications. However, it remains a great challenge to construct well-defined crystalline@amorphous core-shell heterostructured nanomaterials with the same chemical components. Herein, the synthesis of binary (Pd-P) crystalline@amorphous heterostructured nanoplates using Cu3- χ P nanoplates as templates, via cation exchange, is reported. The obtained nanoplate possesses a crystalline core and an amorphous shell with the same elemental components, referred to as c-Pd-P@a-Pd-P. Moreover, the obtained c-Pd-P@a-Pd-P nanoplates can serve as templates to be further alloyed with Ni, forming ternary (Pd-Ni-P) crystalline@amorphous heterostructured nanoplates, referred to as c-Pd-Ni-P@a-Pd-Ni-P. The atomic content of Ni in the c-Pd-Ni-P@a-Pd-Ni-P nanoplates can be tuned in the range from 9.47 to 38.61 at%. When used as a catalyst, the c-Pd-Ni-P@a-Pd-Ni-P nanoplates with 9.47 at% Ni exhibit excellent electrocatalytic activity toward ethanol oxidation, showing a high mass current density up to 3.05 A mgPd -1 , which is 4.5 times that of the commercial Pd/C catalyst (0.68 A mgPd -1 ).

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