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1.
J Med Internet Res ; 23(2): e23786, 2021 Feb 22.
Artigo em Inglês | MEDLINE | ID: mdl-33616534

RESUMO

BACKGROUND: Noncommunicable diseases (NCDs) are associated with the burden of premature deaths and huge medical costs globally. There is an increasing number of studies combining a multiple health behavior change (MHBC) intervention paradigm with eHealth approaches to jointly promote weight-related health behaviors among people with NCD; yet, a comprehensive summary of these studies is lacking. OBJECTIVE: This review aims to meta-analyze the effectiveness and systematically summarize the characteristics of the relevant intervention studies for improving the outcomes of physical activity, healthy diet, and weight among people with NCD. METHODS: Following PRISMA guidelines, 4 electronic databases (PsycINFO, PubMed, Scopus, SPORTDiscus) were systematically searched to identify eligible articles based on a series of inclusion and exclusion criteria. Article selection, quality assessment, and data extraction were independently performed by 2 authors. The standardized mean difference (SMD) was calculated to evaluate the effectiveness of interventions for 3 intervention outcomes (physical activity, healthy diet, and weight), and subsequent subgroup analyses were performed for gender, age, intervention duration, channel, and theory. Calculations were conducted, and figures were produced in SPSS 22 and Review Manager 5.3. RESULTS: Of the 664 original hits generated by the systematic searches, 15 eligible studies with moderate to high quality were included. No potential publication bias was detected using statistical analyses. Studies varied in intervention channel, intensity, and content. The meta-analysis revealed that the eHealth MHBC interventions significantly promoted physical activity (SMD 0.85, 95% CI 0.23 to 1.47, P=.008) and healthy diet (SMD 0.78, 95% CI 0.13 to 1.43, P=.02), but did not contribute to a healthy weight status (SMD -0.13, 95% CI= -0.47 to 0.20, P=.43) among people with NCDs, compared to the control conditions. Results from subgroup analysis indicated that theory-based interventions achieved greater effect than nontheory-based interventions in promoting physical activity, and interventions with traditional approaches (SMS, telephone) were more effective than those with modern internet-based approaches in promoting healthy diet. CONCLUSIONS: The results of this review indicates that eHealth MHBC interventions achieve preliminary success in promoting physical activity and healthy diet behaviors among people with NCD. Future studies could improve the intervention design to achieve better intervention effectiveness. TRIAL REGISTRATION: PROSPERO International Prospective Register of Systematic Reviews CRD42019118629; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=118629.

2.
J Affect Disord ; 280(Pt A): 121-126, 2020 Nov 11.
Artigo em Inglês | MEDLINE | ID: mdl-33207284

RESUMO

BACKGROUND: This study aimed to evaluate cognitive function in patients with anxious depression. METHODS: This was a part of the "Objective Diagnostic Indicators and Individualized Drug Intervention of Major Depressive Disorder (MDD)" study. All participants, including patients with MDD and healthy controls (HCs), completed the 17-item Hamilton Depression Scale (HAMD17) and the Hamilton Anxiety Scale (HAMA). Anxious depression was defined as a HAMD17 anxiety/somatization factor score ≥7. Cognitive function was assessed at baseline and at the end of week 8. HC cognitive function was assessed at baseline. RESULTS: A total of 1048 people were included in the analysis, including 328 patients in the anxious depression group (G1=328), 221 patients in the MDD without anxious depression group (G2=221), and 499 in the HC group (G3=499). There were significant differences in the HAMA at baseline (t=13.050, p<0.001), HAMD17 at baseline (t=16.722, p<0.001), and HAMA at weekend 8 (z=-3.477, p=0.001) between G1 and G2. Cognitive functioning on the Hopkins Verbal Learning Test-Revised (HVLT-R) (t=2.948, p=0.003) and the Brief Visual Memory Test-Revised (BVMT-R) (t=2.843, p=0.005) was better in G1 than in G2 at baseline. Cognitive functioning on the HVLT-R (OR=1.081, p=0.006) was better in G1 than in G2 at weekend 8. The Stroop-color-word test (SCWT) (OR=0.976, p=0.004) and the Continuous Performance Test (CPT) (OR=0.698, p=0.007) showed significant differences at baseline; however, after the acute treatment phase, there were no significant differences in executive function (assessed by SCWT) (p=0.148) or attention/vigilance (assessed by CPT) (p=0.416) between G1 and G3. CONCLUSIONS: Patients with anxious depression have more severe depressive symptoms but better cognitive function, especially for verbal learning, compared with nonanxious depression patients. After the acute treatment phase, executive function and attention/vigilance in anxious depression patients may be remitted.

3.
Sci Total Environ ; 743: 140703, 2020 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-32758831

RESUMO

In recent decades, water quality problems that impact human health, especially groundwater pollution, have been intensely studied, and this has contributed to new ideas and policies around the world such as Low Impact Development (LID) and Superfund legislation. The fundamental to many of these problems is pollutant occurrence and migration in saturated porous media, especially in groundwater. Such environments often contain contrasting zones of high and low permeability with significant differences in hydraulic conductivity (~10-4 and 10-8 m/s, respectively). High-permeability zones (HPZs) represent the primary pathways for pollutant transport in groundwater, while low-permeability zones (LPZs) are often diffusion dominated and serve as both sinks and sources (i.e., via back-diffusion) of pollutants over many decades. In this review, concepts and mechanisms of solute source depletion, contaminant accumulation, and back-diffusion in high- and low-permeability systems are presented, and new insights gained from both experimental and numerical studies are analyzed and summarized. We find that effluent monitoring and novel image analysis techniques have been adroitly used to investigate temporal and spatial evolutions of contaminant concentration; simultaneously, mathematical models are constantly upscaled to verify, optimize and extend the experimental data. However, the spatial concentration data during back-diffusion lacks diversity due to the limitations of pollutant species in studies, the microscopic mechanisms controlling pollutant transformation are poorly understood, and the impacts of these reactions on contaminant back-diffusion are rarely considered. Hence, most simulation models have not been adequately validated and are not capable of accurately predicting pollutant fate and cleanup in realistic heterogeneous aquifers. Based on these, some hypotheses and perspectives are mentioned to promote the investigation of contaminant migration in high- and low-permeability systems in groundwater.

4.
Environ Sci Pollut Res Int ; 27(33): 41623-41638, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32691313

RESUMO

Ethylenediaminetetraacetic acid (EDTA) can serve as a washing agent in the remediation of low-permeability layers contaminated by heavy metals (HMs). Therefore, batch adsorption experiments, where pure quartz (SM1) and mineral mixtures (SM2) were used as typical soil minerals (SMs) in low-permeability layers, were implemented to explore the effects of different EDTA concentrations, pH, and exogenous chemicals on the HM-SM-EDTA adsorption system. As the EDTA concentration increased, it gradually cut down the maximum Cd adsorption capacities of SM1 and SM2 from approximately 135 to 55 mg/kg and 2660 to 1453 mg/kg; and the maximum Pb adsorption capacities of SM1 and SM2 were reduced from 660 to 306 mg/kg and 19,677 to 19,262 mg/kg, respectively. When the initial mole ratio (MR = moles of HM ions/sum of moles of HM ions and EDTA) was closer to 0.5, the effect of EDTA was more effective. Additionally, EDTA worked well at pH below 7.0 and 4.0 for Cd and Pb, respectively. Low-molecular-weight organic acids (LMWOAs) affected the system mainly by bridging, complexation, adsorption site competition, and reductive dissolution. Cu2+, Fe2+ ions could significantly increase the Cd and Pb adsorption onto SM2. Notably, there were characteristic changes in mineral particles, including attachment of EDTA and microparticles, agglomeration, connection, and smoother surfaces, making the specific surface area (SSA) decrease from 16.73 to 12.59 m2/g. All findings indicated that EDTA could effectively and economically reduce the HM adsorption capacity of SMs at the reasonable MR value, contact time, and pH; EDTA reduced the HM adsorption capacity of SMs not only by complexation with HM ions but also by decreasing SSA and blocking active sites. Hence, the acquired insight from the presented study can help to promote the remediation of contaminated low-permeability layers in groundwater.


Assuntos
Metais Pesados , Poluentes do Solo , Adsorção , Cádmio , Ácido Edético , Chumbo , Metais Pesados/análise , Minerais , Permeabilidade , Solo , Poluentes do Solo/análise
5.
Orphanet J Rare Dis ; 15(1): 121, 2020 05 24.
Artigo em Inglês | MEDLINE | ID: mdl-32448241

RESUMO

BACKGROUND: Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a rare congenital disease characterized by uterovaginal agenesis. The diagnosis of MRKH syndrome generally leads to considerable emotional burdens on patients. However, studies focusing on the psychological influence on patients are limited and of unsatisfactory quality. The aim of this study was to investigate the prevalence of depressive symptoms in Chinese patients with MRKH syndrome and to identify the factors associated with depressive symptoms. We recruited 141 patients with MRKH syndrome and 178 age-matched healthy women as control group in this cross-sectional study. Depressive symptoms were assessed by the Patient Health Questionnaire-9 (PHQ-9). Other parameters such as sociodemographic characteristics, treatment histories, personality traits, and attitudes toward femininity and offspring, were also gathered in the self-administered questionnaire. RESULTS: The PHQ-9 score was significantly higher in MRKH patient group than the age-matched control group (7.0 (4.5-11.0) vs. 6.0 (3.0-9.0)), median and IQRs) (P = 0.015). A total of 75.2% of MRKH patients suffered from depressive symptoms, and 34.0% reached a moderate to severe level, while the proportion in the control group was 61.2 and 24.2% respectively. Compared with other age groups, patients in their 20s scored higher on the PHQ-9. Patients with higher neuroticism levels in personality traits (OR 1.19 95% CI 1.11-1.28), negative self-evaluation of femininity (OR 3.964, 95% CI 1.371-11.464) and sexual dysfunction (OR 4.81 95% CI 1.24-18.72) (compared with those having no sexual activity) were more likely to exhibit depressive symptoms. CONCLUSIONS: Three-quarters of MRKH patients show depressive symptoms, and one-third of these individuals are even at risk for depressive disorders. Therefore, depressive symptom screening and proper psychotherapy in MRKH patients are of great importance.

7.
Front Microbiol ; 11: 473, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32292394

RESUMO

Mosquito-borne flaviviruses (MBFVs) spread between vertebrate (mammals and birds) and invertebrate (mosquitoes) hosts. The cis-acting RNAs of MBFV share common evolutionary origins and contain frequent alterations, which control the balance of linear and circular genome conformations and allow effective replication. Importantly, multiple cis-acting RNAs interact with trans-acting regulatory RNA-binding proteins (RBPs) and affect the MBFV lifecycle process, including viral replicase binding, viral RNA translation-cyclisation-synthesis and nucleocapsid assembly. Considering that extensive structural probing analyses have been performed on MBFV cis-acting RNAs, herein the homologous RNA structures are online folded and consensus structures are constructed by sort. The specific traits and underlying biology of MBFV cis-acting RNA are illuminated accordingly in a review of RNA structure. These findings deepen our understanding of MBFV cis-acting RNA biology and serve as a resource for designing therapeutics in targeting protein-viral RNA interaction or viral RNA secondary structures.

8.
Sci Total Environ ; 721: 137624, 2020 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-32171137

RESUMO

The occurrence, partition, and human health risk of thirteen pharmaceuticals and personal care products (PPCPs) have been investigated in surface water, overlying water, pore water and sediment samples from Dianshan Lake of Yangtze River Delta Ecology and Greenery Integration Development Demonstration Zone in China. PPCPs were ubiquitous in aqueous phase and sediments from Dianshan Lake. Sulfamethazine (SMZ) was dominated in surface water and overlying water, while ketoprofen (KPF) was rich in sediment. The total concentration of PPCPs ranged from 0.38-85.27 ng/L, 24.26-130.03 ng/L and 5.39-149.84 µg/kg in surface water, overlying water and sediment, respectively, which were in middle levels compared with these reported in other aquatic environment in China. Naproxen (NPX), sulfadimethoxine (SDM), sulfamethoxazole (SMX) and sulfamethazine (SMZ) in surface water showed a relatively higher level in lake side than those in lake center suggesting that a mixed containment source of human- and animal-derived from the areas around lake. The significant season variations of most PPCPs were mainly attributed to their usage, water temperature and dilution effect. The partition behaviors of PPCPs in sediment-overlying water and sediment-pore water system were mainly affected by their logKow values, and showed weak correlation with total organic carbon (TOC) content in sediment and molecular weights of PPCPs. Preliminary results indicated that PPCPs in Dianshan Lake have not posed a high risk to human health by exposure to drinking water for all age groups. Nevertheless, their potential to cause the mixture toxicity and resistance genes cannot be neglected. This work will contribute to the clear picture of PPCPs contamination in drinking water source in the Demonstration Zone, and provide reliable and simple-to-use information to regulators on the exposure and risk levels of PPCPs, as well as recommendations for future research.


Assuntos
Cosméticos/análise , Água Potável , Preparações Farmacêuticas , Poluentes Químicos da Água/análise , Animais , China , Monitoramento Ambiental , Humanos , Medição de Risco , Rios
9.
J Virol ; 94(9)2020 04 16.
Artigo em Inglês | MEDLINE | ID: mdl-32075929

RESUMO

Duck Tembusu virus (DTMUV), which is similar to other mosquito-borne flaviviruses that replicate well in most mammalian cells, is an emerging pathogenic flavivirus that has caused epidemics in egg-laying and breeding waterfowl. Immune organ defects and neurological dysfunction are the main clinical symptoms of DTMUV infection. Preinfection with DTMUV makes the virus impervious to later interferon (IFN) treatment, revealing that DTMUV has evolved some strategies to defend against host IFN-dependent antiviral responses. Immune inhibition was further confirmed by screening for DTMUV-encoded proteins, which suggested that NS2A significantly inhibited IFN-ß and IFN-stimulated response element (ISRE) promoter activity in a dose-dependent manner and facilitated reinfection with duck plague virus (DPV). DTMUV NS2A was able to inhibit duck retinoic acid-inducible gene-I (RIG-I)-, and melanoma differentiation-associated gene 5 (MDA5)-, mitochondrial-localized adaptor molecules (MAVS)-, stimulator of interferon genes (STING)-, and TANK-binding kinase 1 (TBK1)-induced IFN-ß transcription, but not duck TBK1- and interferon regulatory factor 7 (IRF7)-mediated effective phases of IFN response. Furthermore, we found that NS2A competed with duTBK1 in binding to duck STING (duSTING), impaired duSTING-duSTING binding, and reduced duTBK1 phosphorylation, leading to the subsequent inhibition of IFN production. Importantly, we first identified that the W164A, Y167A, and S361A mutations in duSTING significantly impaired the NS2A-duSTING interaction, which is important for NS2A-induced IFN-ß inhibition. Hence, our data demonstrated that DTMUV NS2A disrupts duSTING-dependent antiviral cellular defenses by binding with duSTING, which provides a novel mechanism by which DTMUV subverts host innate immune responses. The potential interaction sites between NS2A and duSTING may be the targets of future novel antiviral therapies and vaccine development.IMPORTANCE Flavivirus infections are transmitted through mosquitos or ticks and lead to significant morbidity and mortality worldwide with a spectrum of manifestations. Infection with an emerging flavivirus, DTMUV, manifests with clinical symptoms that include lesions of the immune organs and neurological dysfunction, leading to heavy egg drop and causing serious harm to the duck industry in China, Thailand, Malaysia, and other Southeast Asian countries. Mosquito cells, bird cells, and mammalian cell lines are all susceptible to DTMUV infection. An in vivo study revealed that BALB/c mice and Kunming mice were susceptible to DTMUV after intracerebral inoculation. Moreover, there are no reports about DTMUV-related human disease, but antibodies against DTMUV and viral RNA were detected in serum samples of duck industry workers. This information implies that DTMUV has expanded its host range and may pose a threat to mammalian health. However, the pathogenesis of DTMUV is largely unclear. Our results show that NS2A strongly blocks the STING-induced signal transduction cascade by binding with STING, which subsequently blocks STING-STING binding and TBK1 phosphorylation. More importantly, the W164, Y167, or S361 residues in duSTING were identified as important interaction sites between STING and NS2A that are vital for NS2A-induced IFN production and effective phases of IFN response. Uncovering the mechanism by which DTMUV NS2A inhibits IFN in the cells of its natural hosts, ducks, will help us understand the role of NS2A in DTMUV pathogenicity.


Assuntos
Flavivirus/metabolismo , Interferon beta/metabolismo , Proteínas Virais/metabolismo , Animais , Linhagem Celular , Patos/virologia , Flavivirus/patogenicidade , Infecções por Flavivirus/virologia , Humanos , Imunidade Inata/imunologia , Fator Regulador 7 de Interferon , Interferons/metabolismo , Proteínas de Membrana , Proteínas Serina-Treonina Quinases , Transdução de Sinais/imunologia , Proteínas não Estruturais Virais/metabolismo
10.
Environ Sci Pollut Res Int ; 27(13): 15188-15197, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32072419

RESUMO

Transport of environmental pollutants in groundwater systems can be greatly influenced by colloids. In this study, the cotransport of Pb2+ and silica (SiO2) colloids at different Pb2+ concentrations was systematically investigated by batch adsorption and saturated sand column experiments. Results showed that SiO2 colloids had low adsorption capacity for Pb2+ (less than 1% of the input) compared with sands. In saturated porous media, SiO2 colloids showed a high mobility; however, with the increase of Pb2+ concentration in the sand column, the mobility of SiO2 colloids gradually decreased. Notably, SiO2 colloids could facilitate Pb2+ transport, although they did not serve as effective carriers of Pb2+. Under the condition of low Pb2+ concentration, SiO2 colloids promoted the Pb2+ transport mainly through the way of "transport channel," while changing the porosity of the medium and masking medium adsorption sites were the main mechanisms of SiO2 colloid-facilitated Pb2+ transport under the condition of high Pb2+ concentration. The discovery of this non-adsorption effect of colloids would improve our understanding of colloid-facilitated Pb2+ transport in saturated porous media, which provided new insights into the role of colloids, especially colloids with weak Pb2+ adsorption capacity, in Pb2+ occurrence and transport in soil-groundwater systems.


Assuntos
Chumbo , Dióxido de Silício , Adsorção , Coloides , Porosidade
11.
PLoS One ; 15(1): e0227182, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31914138

RESUMO

OBJECTIVES: Fluctuation is a common but neglected phenomenon of physical activity (PA) behavior. This study aimed to explore the psychosocial profiles of PA fluctuation in office employees, and to examine the association of latent profiles with demographics and PA level. METHOD: 434 Chinese office employees who were identified as PA fluctuators (M = 32.4 years, SD = 6.9, 55.5% female) completed a cross-sectional online survey covering demographics, PA behavior, and six psychosocial indicators (self-efficacy, planning, action control, affective attitude, social support, and perceived barriers). Latent profile analysis was used to determine PA fluctuators' psychosocial profiles. Associated factors of profile membership were identified with multinomial logistic regression. RESULTS: The two-profile model (uncommitted vs. moderately committed) was selected as the best solution. The moderately committed group (n = 346, 79.7%) possessed a more active mindset by reporting significantly higher scores of self-efficacy (t = 9.42 p < .001), planning (t = 16.33 p < .001), action control (t = 14.55 p < .001), affective attitude (t = 13.33 p < .001), and social support (t = 11.50 p < .001) compared with the uncommitted group (n = 88, 20.3%). Results from a multinomial logistic regression showed that the moderately committed profile was associated with normal weight status (OR = 2.00, p< .05), having a medium managerial position (OR = 2.54, p< .01), and high level of moderate to vigorous PA behavior (OR = 4.85, p< .001). CONCLUSIONS: These findings demonstrate the variability of PA fluctuators' mindsets. Future tailored interventions are recommended to promote PA behavior for this population based on the categorization from the present study.


Assuntos
Pessoal Administrativo/psicologia , Exercício Físico/psicologia , Comportamentos Relacionados com a Saúde , Adulto , Algoritmos , Atitude , China , Estudos Transversais , Feminino , Humanos , Atividades de Lazer/psicologia , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Autoeficácia , Autorrelato , Apoio Social
12.
Chin Med J (Engl) ; 133(4): 388-394, 2020 Feb 20.
Artigo em Inglês | MEDLINE | ID: mdl-31977552

RESUMO

BACKGROUND: As a congenital malformation that results in infertility and an inability to have vaginal intercourse, Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome places a considerable psychological burden on patients, which results in anxiety symptoms. However, only single case studies or a few small to medium-sized cross-sectional studies were identified to focus on anxiety symptoms in MRKH patients. Thus, the aim of this study was to explore the status of anxiety symptoms and the related factors in patients with MRKH syndrome. METHODS: This cross-sectional study involving 141 patients with MRKH syndrome and 178 healthy women was conducted from January 2018 to December 2018. All participants were required to complete a demographic questionnaire and the Generalized Anxiety Disorder 7-item scale (GAD-7), Patient Health Questionnaire-9, Eysenck Personality Questionnaire-Revised, Short Scale for Chinese, and Chinese Version of the Female Sexual Function Index. The main outcome was the anxiety symptoms measured by the GAD-7. Main outcome was compared between the MRKH syndrome group and the healthy control group. Then, we explored the related factors by comparing patients with and without anxiety symptoms. RESULTS: Of the respondents, 24.1% experienced moderate to severe anxiety symptoms. Patients with MRKH syndrome manifested more severe anxiety symptoms than healthy women. Negative self-evaluation of femininity (odds ratio [OR] 2.706, 95% confidence interval [CI] 1.010-7.247), neurotic personality traits (OR 1.100, 95% CI 1.029-1.175), and coexisting depressive symptoms (OR 4.422, 95% CI 1.498-13.049) were more prevalent in anxious patients. CONCLUSION: The findings stress the importance of anxiety symptom screening in MRKH patients and identify patients at risk of anxiety symptoms, providing a possible basis for future intervention.

13.
Sci Total Environ ; 706: 135708, 2020 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-31787287

RESUMO

Pollutant accumulation in the low-permeability zones (LPZs) in groundwater systems is regarded as a secondary source, and its consequent back-diffusion can extend the timeframe of pump-and-treat remediation. However, the bioavailability and mobility of heavy metals and the medium characteristics can be changed during the process. This study investigated the accumulation and back-diffusion law of toxic metals and the effects of ethylenediaminetetraacetic acid disodium salt (EDTA-2Na) on them by implementing a series of tank experiments. In these experiments, a cadmium solution was injected first, and deionized water or EDTA-2Na constantly washed the system consisting of different medium layers. The experimental results showed that the cadmium breakthrough curves had some concentration gradient reverse points where the curves fluctuated with elution by deionized water, which did not exist when EDTA-2Na was the eluent. In these scenarios, the mass of accumulated cadmium in the media before elution was large, with a value of 931 mg (153 mg/kg), when the low-permeability medium was clay. However, when EDTA-2Na was injected together with cadmium, the value dropped to 319 mg (52.3 mg/kg), greatly reducing the cadmium accumulation. Additionally, the use of EDTA-2Na as an eluent resulted in the appearance of a secondary peak in the breakthrough curve, showing that EDTA-2Na accelerated and centralized the back-diffusion. Notably, the reduced cadmium accumulation in LPZs with the elution by EDTA-2Na was partly due to a reduced adsorption capacity of the clay minerals. The above results can advance the technology related to pump-and-treat remediation.

14.
BMC Psychiatry ; 19(1): 353, 2019 11 08.
Artigo em Inglês | MEDLINE | ID: mdl-31703657

RESUMO

BACKGROUND: Bipolar disorder is associated with complicated medical comorbidities. The risk-taking behavior of bipolar disorder patients may lead to many problems. CASE PRESENTATION: A 40-year-old male patient had gastrointestinal symptoms for 4 months. He was talkative, agitative, and grandiose but showed poor cognition. Multisystem injury required multidepartment, multidisciplinary consultation. Repeated fecal examination found multiple infections of Opisthorchis sinensis, Heterophyes, and Echinostomatidae. The diagnostic criteria for parasitic infections, bipolar disorder and organic mental disorder were met. After treatment with a mood stabilizer and helminthic, his mood became stable, but risky dietary behavior continued. CONCLUSIONS: The case describes persistent risky dietary behaviors in a bipolar patient even after affective symptoms were under control, which ultimately led to diverse parasitic infections and chronic encephalopathy. We call for clinical and scientific attention to possible dangerous behavior changes in bipolar patients even after their emotions are stabilized.


Assuntos
Transtorno Bipolar/psicologia , Dieta/psicologia , Comportamento Alimentar/psicologia , Assunção de Riscos , Adulto , Afeto , Sintomas Afetivos/psicologia , Emoções , Humanos , Masculino
15.
Viruses ; 11(10)2019 10 10.
Artigo em Inglês | MEDLINE | ID: mdl-31658680

RESUMO

Flaviviruses, most of which are emerging and re-emerging human pathogens and significant public health concerns worldwide, are positive-sense RNA viruses. Flavivirus replication occurs on the ER and is regulated by many mechanisms and factors. NS5, which consists of a C-terminal RdRp domain and an N-terminal methyltransferase domain, plays a pivotal role in genome replication and capping. The C-terminal RdRp domain acts as the polymerase for RNA synthesis and cooperates with diverse viral proteins to facilitate productive RNA proliferation within the replication complex. Here, we provide an overview of the current knowledge of the functions and characteristics of the RdRp, including the subcellular localization of NS5, as well as the network of interactions formed between the RdRp and genome UTRs, NS3, and the methyltransferase domain. We posit that a detailed understanding of RdRp functions may provide a target for antiviral drug discovery and therapeutics.


Assuntos
Flavivirus , Replicação Viral/genética , Vírus da Dengue/genética , Flavivirus/genética , Flavivirus/metabolismo , Genoma Viral , Humanos , Metiltransferases/genética , RNA Viral/metabolismo , /genética , Regiões não Traduzidas/genética , Proteínas não Estruturais Virais/genética , Proteínas não Estruturais Virais/metabolismo , Proteínas Virais/genética , Proteínas Virais/metabolismo , Vírus da Febre Amarela/genética , Zika virus/genética
16.
J Sport Health Sci ; 8(5): 412-421, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31534816

RESUMO

Background: With an increase in the evidence for the associations between park-based physical activity (PA) and physical environments (especially park and neighborhood environments), researchers face an important challenge in interpreting and summarizing the evidence to develop environmental change interventions. An updated review is needed to better inform policymaking and environmental interventions. The current study aimed to systematically review the research on the associations of park-based PA with park and neighborhood environmental characteristics. Methods: We targeted English peer-reviewed articles from 5 electronic databases using keywords related to park-based PA, park environments, and neighborhood environments. Of the 4071 identified papers, 25 studies published between 2008 and 2016 met all the eligibility criteria and were included in this review. Results: The characteristics of physical environment that received consistent support included paths/trails, lighting, and incivilities (e.g., broken glasses and litter). Mixed findings were revealed for 6 park environmental factors (unspecified active facilities, playgrounds and skating areas, fitness stations, picnic areas, greenness, and park size) and 2 neighborhood environmental factors (park density and park proximity). Conclusion: It can be concluded that paths/trails, lighting, and incivilities are 3 key physical environmental attributes of park-based PA. Given the inconsistent findings on park and neighborhood environmental factors, more robust designs such as prospective investigation are required.

17.
Artigo em Inglês | MEDLINE | ID: mdl-31443443

RESUMO

AIMS: The present study aimed to examine and compare the socioecological correlates of park-based physical activity (PA) among Hong Kong and Leipzig older adults in terms of types of activity areas, perceived park environment, psychosocial factors, and the interactions between the perceived park environmental and psychosocial factors. METHODS: Based on the SOPARC, systematic observations were conducted in six randomly selected urban parks in each city. A total of 317 Hong Kong (Mage = 69.96; SD = 6.81) and 311 Leipzig (Mage = 72.06; SD = 6.78) older adults from these six parks completed an interviewer-delivered survey measuring their perceived park environment, psychosocial variables, and park-based PA. RESULTS: In both cities, the types of activity areas were positively associated with the number of older adults observed being active in parks. Psychosocial factors, especially self-efficacy and perceived barriers, had larger associations with park-based PA compared with the perceived park environment. The interaction between perceived park features and self-efficacy in the association with park-based PA was found in Leipzig, but not in Hong Kong. CONCLUSION: Findings of the current study contribute to the cross-cultural understanding of the socioecological correlates of park-based PA among older adults.


Assuntos
Exercício Físico , Parques Recreativos , Características de Residência/estatística & dados numéricos , Idoso , Idoso de 80 Anos ou mais , Cidades , Feminino , Alemanha , Hong Kong , Humanos , Masculino , Pessoa de Meia-Idade
18.
J Affect Disord ; 256: 1-7, 2019 09 01.
Artigo em Inglês | MEDLINE | ID: mdl-31154087

RESUMO

BACKGROUND: This study aimed to evaluate the effect of short-term use of benzodiazepines (BZDs) on cognitive function of major depressive disorder (MDD) patients being treated with antidepressants (ADs). METHODS: This was a part of a multi-center, multi-stage and prospective study of "Objective Diagnostic Indicators and Individualized Drug Intervention of Major Depressive Disorder (OIMDD)". Three hundred and fifty-three patients treated with the selective serotonin reuptake inhibitors (SSRIs) alone (Group 1) and 49 patients treated with SSRIs combined with short-term use of BZDs (Group 2) during the acute treatment period were included in the analysis. Cognitive function and depressive and anxiety symptoms were assessed at baseline, weekend 8 and 48. A cognitive test battery included 5 domains: information processing speed assessed by the Animal Verbal Fluency Scale (AVFS), Digit Symbol Coding Test (DSCT) and Color Trial Test (CTT), verbal learning assessed by the Hopkins Verbal Learning Test-Revised (HVLT-R), visual learning assessed by the Brief Visual Memory Test-Revised (BVMT-R), executive function assessed by the Stroop Color Word Test (SCWT), and attention or vigilance assessed by the Continuous Performance Test (CPT). RESULTS: Significant differences were found in education level (χ2 = 5.442, p = 0.020), the severity of depressive (t = -1.982, p = 0.048) and anxiety symptoms (t = -2.629, p = 0.009) between Group 1 and 2 at baseline. There were no significant differences between G1 and G2 in cognitive functions at baseline. After Multiple correction, DSCT was better in patients treated with BZDs combined with ADs than in patients with ADs alone at weekend 8 without controlling education level, depressive and anxiety symptoms at baseline (F = -2.747, p = 0.042). After controlling these factors at baseline, the DSCT was still slightly high in patients treated with ADs combined with BZDs than in patients with ADs alone at weekend 8 (OR = 1.052, 95%CI:1.000-1.105). The repeated measurement analysis of variance showed that the DSCT could be improved by the treatment of BZDs combined with ADs at 1-year follow-up compared to baseline (F = 7.569, p = 0.006). CONCLUSIONS: The findings suggest that short-term use of BZDs does not impair cognitive function of MDD patients; conversely, it could improve the information processing speed after acute treatment and at 1 year follow up.


Assuntos
Antidepressivos/uso terapêutico , Benzodiazepinas/uso terapêutico , Cognição/efeitos dos fármacos , Transtorno Depressivo Maior/tratamento farmacológico , Adulto , Ansiedade , Atenção , Função Executiva , Feminino , Humanos , Masculino , Memória , Pessoa de Meia-Idade , Estudos Prospectivos , Inibidores de Captação de Serotonina/uso terapêutico
19.
Poult Sci ; 98(7): 2989-2996, 2019 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-30915447

RESUMO

Duck Tembusu virus (DTMUV) non-structural protein 5 (NS5), which harbors an N-terminal methyltransferase (MTase) domain and a C-terminal RNA-dependent RNA polymerase (RdRp) domain, is central to virus replication. In this study, a sequence encoding amino acid residues 1-408 of NS5 was amplified and ligated into a pET32a vector to generate a pET32a-NS51-408 expression vector. Recombinant protein was expressed, purified, and used to arise a mouse anti-NS5 specific polyclonal antibody (DTMUV-NS51-408 mPAb). Indirect immunofluorescence assays indicated that NS5 protein localized within the cytoplasmic region of DTMUV-infected or transfected cells; the localization was not affected in the presence of a nuclear export inhibitor. This study provides the first demonstration that, in contrast to the data reported for NS5 proteins of Dengue and Yellow fever virus, DTMUV NS5 had slight nuclear localization activity.


Assuntos
Citoplasma/virologia , Flavivirus/fisiologia , Proteínas não Estruturais Virais/análise , Animais , Anticorpos Antivirais , Linhagem Celular , Células Cultivadas , Cricetinae , Patos , Feminino , Flavivirus/imunologia , Camundongos Endogâmicos BALB C , Doenças das Aves Domésticas/virologia , Proteínas Recombinantes
20.
Front Psychiatry ; 9: 659, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30564156

RESUMO

Objective: To integrate high-quality evidence of the efficacy of antidepressants across different subtypes of functional gastrointestinal disorders (FGIDs). Methods: The Medline, PsycINFO, EMBASE, the Cochrane Library, and Chinese local database were searched up to October 1, 2017. Keywords included all subtypes of FGIDs, antidepressants, and randomized controlled trials (RCTs). We included RCTs with low to moderate risks of bias in comparing antidepressants with placebos as the only intervention in treating adult patients with FGIDs (PROSPERO ID: CRD42015030123). Language was restricted to English or Chinese. Data extraction was independently carried out by two authors, following the Cochrane Handbook for systematic reviews. Results: Of 2,460 records identified, 31 studies reporting on 2,340 participants were included in the meta-analysis. Antidepressants were more effective than placebos in terms of the rate of responder [RR = 1.35 (95% CI 1.12 to 1.63)], and the reduction of target gastrointestinal symptoms [SMD = -0.94 (95% CI -1.33 to -0.54)], and disability severity (moderate effect sizes). Those effects partly remained both at the presence and absence of comorbid depression, and among different subtypes of FGIDs. Subgroup analyses confirmed the benefit of tricyclic and tetracyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs), and trazodone. Efficacy of serotonin and norepinephrine reuptake inhibitors (SNRIs), low doses of antidepressants, and antidepressants in intermediate to long term treatment was inconclusive due to the scarcity of eligible evidence. Compared to placebo, patients on antidepressants reported more adverse events [RR = 1.91 (95% CI 1.23 to 2.96)] and more frequent withdrawal. On average one in 7.4 (95% CI 5.4 to 11.9) patients treated with antidepressants responded, while one in 4.8 (95% CI 3.7 to 6.8) experienced certain adverse effects. Conclusions: Antidepressants were inferior to placebo in terms of tolerability and partly superior regarding efficacy. Before prescribing antidepressants, the benefits and side effects should be carefully evaluated.

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