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Front Aging Neurosci ; 14: 862107, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35462694


Background: Interhemispheric and intrahemispheric long-range synchronization and information communication are crucial features of functional integration between the bilateral hemispheres. Previous studies have demonstrated that disrupted functional connectivity (FC) exists in the bilateral hemispheres of patients with carpal tunnel syndrome (CTS), but they did not clearly clarify the phenomenon of central dysfunctional connectivity. This study aimed to further investigate the potential mechanism of the weakened connectivity of primary somatosensory cortex (S1) based on a precise template. Methods: Patients with CTS (n = 53) and healthy control subjects (HCs) (n = 23) participated and underwent resting-state functional magnetic resonance imaging (rs-fMRI) scanning. We used FC to investigate the statistical dependency of the whole brain, effective connectivity (EC) to analyze time-dependent effects, and voxel-mirrored homotopic connectivity (VMHC) to examine the coordination of FC, all of which were adopted to explore the change in interhemispheric and intrahemispheric S1. Results: Compared to the healthy controls, we significantly found a decreased strength of the two connectivities in the interhemispheric S1 hand , and the results of EC and VMHC were basically consistent with FC in the CTS. The EC revealed that the information output from the dominant hemisphere to the contralateral hemisphere was weakened. Conclusion: This study found that maladjusted connections between and within the bilateral S1 revealed by these methods are present in patients with CTS. The dominant hemisphere with deafferentation weakens its effect on the contralateral hemisphere. The disturbance in the bilateral S1 provides reliable evidence to understand the neuropathophysiological mechanisms of decreased functional integration in the brains of patients with CTS.

BMJ Open ; 12(1): e053991, 2022 Jan 13.
Artigo em Inglês | MEDLINE | ID: mdl-35027421


INTRODUCTION: Stroke survivors can have a high disability rate with low quality of daily life, resulting in a heavy burden on family and society. Transcranial magnetic stimulation has been widely applied to brain injury repair, neurological disease treatment, cognition and emotion regulation and so on. However, there is still much to be desired in the theories of using these neuromodulation techniques to treat stroke-caused hemiplegia. It is generally recognised that synaptic plasticity is an important basis for functional repair after brain injury. This study protocol aims to examine the corticocortical paired associative stimulation (ccPAS) for inducing synaptic plasticity to rescue the paralysed after stroke. METHODS AND ANALYSIS: The current study is designed as a 14-week double-blind randomised sham-controlled clinical trial, composed of 2-week intervention and 12-week follow-up. For the study, 42 patients who had a stroke aged 40-70 will be recruited, who are randomly assigned either to the ccPAS intervention group, or to the control group at a 1:1 ratio, hence an equal number each. In the intervention group, ccPAS is practised in conjunction with the conventional rehabilitation treatment, and in the control group, the conventional rehabilitation treatment is administered with sham stimulation. A total of 10 interventions will be made, 5 times a week for 2 weeks. The same assessors are supposed to evaluate the participants' motor function at four time points of the baseline (before 10 interventions), treatment ending (after 10 interventions), and two intervals of follow-up (1 and 3 months later, respectively). The Fugl-Meyer Assessment Upper Extremity is used for the primary outcomes. The secondary outcomes include changes in the assessment of Action Research Arm Test (ARAT), Modified Barthel Index (MBI), electroencephalogram (EEG) and functional MRI data. The adverse events are to be recorded throughout the study. ETHICS AND DISSEMINATION: This study was approved by the Medical Ethics Committee of Yueyang Hospital. All ethical work was performed in accordance with the Helsinki declaration. Written informed consent was obtained from all individual participants included in the study. Study findings will be disseminated in the printed media. TRIAL REGISTRATION NUMBER: Chinese Clinical Trial Registry: ChiCTR2000036685.

Reabilitação do Acidente Vascular Cerebral , Acidente Vascular Cerebral , Adulto , Idoso , Método Duplo-Cego , Hemiplegia/complicações , Hemiplegia/terapia , Humanos , Pessoa de Meia-Idade , Ensaios Clínicos Controlados Aleatórios como Assunto , Acidente Vascular Cerebral/complicações , Acidente Vascular Cerebral/terapia , Reabilitação do Acidente Vascular Cerebral/métodos , Resultado do Tratamento , Extremidade Superior
Huan Jing Ke Xue ; 29(4): 879-83, 2008 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-18637332


Based on 9-month monitoring field data, this paper analyzes the variation of chlorophyll-a (Chl-a), total phosphorus (TP), total nitrogen (TN) and transparency (SD) in different sub-lake districts in order to study the treatment effect of eutrophication restoration project in Lichee Lake in Shenzhen. The statistical results show that, the average of TP and TN for whole lake were below 0.1 mg x L(-1) and 1.5 mg x L(-1) respectively, the average of Chl-a of north lake district and east lake district were 16.77 microg x L(-1) and 21.45 microg x L(-1) respectively, lower than that of south lake district (35.83 microg x L(-1) and west lake district (32.69 microg x L(-1)), and the average of SD for whole lake was greater than 0.5 m. During the 9-month operation of the restoration project, the average water quality satisfied the National Standard IV for surface water and the water was improved from hypereutrophic status to eutrophic status in Lake.

Clorofila/análise , Eutrofização , Água Doce/análise , Poluentes Químicos da Água/análise , China , Clorofila A , Monitoramento Ambiental , Recuperação e Remediação Ambiental , Nitrogênio/análise , Fósforo/análise