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1.
Indian J Psychiatry ; 64(2): 185-191, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35494327

RESUMO

Background: Mental disorders are one of the leading causes of illness and disability worldwide. According to the World Health Organization (WHO), one in four people in the world will be affected by mental or neurological disorders during their lifetime. Regular evaluation of mental health outcomes plays an important role in making decisions about timely treatment of the patient. Studies show that a medical record does not provide enough information about the diagnosis, current symptoms, psychiatric medications, and side effects of current medications and treatments for ongoing health care. In this study, the completeness of paper-based psychiatric records was investigated. Aim: The current study aimed to explore the completeness rate of paper-based psychiatric medical records (PMRs) and to investigate the factors effective on documentation status. Setting: The study was conducted in Ebnesina and Dr. Hejazi Psychiatric Hospital and Education Center. The case hospital is a psychiatric teaching hospital, which has 900 beds. Materials and Methods: The completeness rate of PMRs was determined using descriptive statistics. Fleiss' Kappa agreement and effective factors on PMRs' documentation status were assessed. Results: In total, 83.65% (n = 312) of the PMRs had at least one documentation defect. A significantly higher level of documentation completeness rate between different psychiatric wards was observed. Conclusion: Based on our results, it is suggested to conduct regular evaluation and provide feedback to the health-care providers, and conduct training courses.

2.
Ann Thorac Surg ; 2022 Mar 16.
Artigo em Inglês | MEDLINE | ID: mdl-35305991

RESUMO

Management of rare ascending aortic complications following transcatheter aortic valve replacement (TAVR) remains a poorly defined area of knowledge. Furthermore, since most patients undergoing TAVR are intermediate to high surgical risk, the treatment of such complications often requires endovascular approaches. Herein, we present a novel technique of endovascular ascending stent graft delivery from the innominate artery for the treatment of a Type A Aortic Dissection (TAAD) after self-expandable TAVR implantation, specifically addressing the landing of the aortic stent within the crown of the TAVR valve.

3.
Bull Menninger Clin ; 86(1): 48-66, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35258347

RESUMO

Studies on the psychopathy construct are mostly limited to Western cultures, and there is a lack of research in this area in non-Western countries, specifically in Iran. The present study aimed to examine the factor structure, internal consistency, and convergent validity of the Persian version of the Youth Psychopathic Traits Inventory-Short Version (YPI-S) with a sample of 668 school-attending adolescents in Iran (46% girls; Mage = 16.35). Confirmatory factor analysis supported the proposed three-factor model. While the internal consistency of some YPI-S scores was unsatisfactory, the YPI-S scores showed the expected relations with external correlates (e.g., aggression, hyperactivity), supporting the validity of YPI-S scores. The authors' results supported the YPI-S for assessing psychopathic traits in Iranian adolescents. The modification of the YPI-S factor structure, the low factor loadings of some YPI-S items, and the inadequate internal consistency of some YPI-S dimensions indicate cultural influences on the assessment of cross-cultural traits.


Assuntos
Transtorno da Personalidade Antissocial , Adolescente , Transtorno da Personalidade Antissocial/diagnóstico , Análise Fatorial , Feminino , Humanos , Irã (Geográfico) , Masculino , Inventário de Personalidade , Psicometria , Reprodutibilidade dos Testes
4.
Elife ; 112022 03 15.
Artigo em Inglês | MEDLINE | ID: mdl-35289269

RESUMO

Microbial foraging in patchy environments, where resources are fragmented into particles or pockets embedded in a large matrix, plays a key role in natural environments. In the oceans and freshwater systems, particle-associated bacteria can interact with particle surfaces in different ways: some colonize only during short transients, while others form long-lived, stable colonies. We do not yet understand the ecological mechanisms by which both short- and long-term colonizers can coexist. Here, we address this problem with a mathematical model that explains how marine populations with different detachment rates from particles can stably coexist. In our model, populations grow only while on particles, but also face the increased risk of mortality by predation and sinking. Key to coexistence is the idea that detachment from particles modulates both net growth and mortality, but in opposite directions, creating a trade-off between them. While slow-detaching populations show the highest growth return (i.e., produce more net offspring), they are more susceptible to suffer higher rates of mortality than fast-detaching populations. Surprisingly, fluctuating environments, manifesting as blooms of particles (favoring growth) and predators (favoring mortality) significantly expand the likelihood that populations with different detachment rates can coexist. Our study shows how the spatial ecology of microbes in the ocean can lead to a predictable diversification of foraging strategies and the coexistence of multiple taxa on a single growth-limiting resource.


Assuntos
Meio Ambiente , Comportamento Predatório , Animais , Ecossistema , Água Doce , Modelos Teóricos , Oceanos e Mares
5.
Nat Commun ; 13(1): 1657, 2022 03 29.
Artigo em Inglês | MEDLINE | ID: mdl-35351873

RESUMO

Sinking particulate organic carbon out of the surface ocean sequesters carbon on decadal to millennial timescales. Predicting the particulate carbon flux is therefore critical for understanding both global carbon cycling and the future climate. Microbes play a crucial role in particulate organic carbon degradation, but the impact of depth-dependent microbial dynamics on ocean-scale particulate carbon fluxes is poorly understood. Here we scale-up essential features of particle-associated microbial dynamics to understand the large-scale vertical carbon flux in the ocean. Our model provides mechanistic insight into the microbial contribution to the particulate organic carbon flux profile. We show that the enhanced transfer of carbon to depth can result from populations struggling to establish colonies on sinking particles due to diffusive nutrient loss, cell detachment, and mortality. These dynamics are controlled by the interaction between multiple biotic and abiotic factors. Accurately capturing particle-microbe interactions is essential for predicting variability in large-scale carbon cycling.


Assuntos
Ciclo do Carbono , Água do Mar , Carbono/metabolismo
6.
An Bras Dermatol ; 2022 Feb 16.
Artigo em Inglês | MEDLINE | ID: mdl-35183396

RESUMO

BACKGROUND: Vitiligo is a common disease with a high burden, and its recalcitrant type is unresponsive to current medical treatments. Autologous non-cultured and trypsinized melanocyte grafting, which is a simple and experience-based procedure, has been suggested for the treatment of vitiligo. OBJECTIVE: To assess autologous non-cultured and trypsinised melanocyte grafting in recalcitrant vitiligo. METHODS: This clinical trial was done on 28 patients (20 females and 8 males). After demarcation and preparation of both donor and recipient sites, both sites were shaved by a curette. The materials harvested from the donor site were trypsinized and centrifuged. The resulting suspension was mixed with hyaluronic acid gel and was spread over the shaved recipient area. RESULTS: Twenty-eight patients with a total of 108 lesions and a mean age of 25.93 ± 7.11 years were included in the present study. Generalized vitiligo (57.1%) was the most common clinical type and the face and neck regions (38%) were the most frequent treated sites. Good to excellent repigmentation was seen in the face and neck, trunk, upper extremity, and genitals in 31 (57.4%), 11 (20.4%), 9 (16.7%) and 3 (5.5%) patients, respectively. Face and neck showed significantly better results (p < 0.05). STUDY LIMITATIONS: Low sample size and single-center study. CONCLUSION: Autologous non-cultured and trypsinized melanocyte grafting is a safe method with satisfactory outcomes in recalcitrant vitiligo. Appropriate training of physicians and proper use of specialists' experiences can be effective in increasing the improvement rate.

7.
Phytother Res ; 36(4): 1797-1806, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-35178811

RESUMO

Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to cartilage damage with mostly accompanied by metabolic disorders. This study aimed to investigate the effects of curcumin supplementation on metabolic parameters (lipid profile and glycemic indices), inflammatory factors, visfatin levels, and obesity values in women with RA. This randomized, double-blind, placebo-controlled clinical trial was conducted on 48 women with RA. The patients were treated with curcumin (500 mg once a day) or placebo for 8 weeks. Fasting blood samples, anthropometric measurements, dietary intakes, and physical activity levels of subjects were collected at baseline and the end of the study. Curcumin supplementation significantly decreased homeostatic model assessment for insulin resistance (HOMA-IR), erythrocyte sedimentation rate, serum levels of high-sensitivity C-reactive protein and triglycerides, weight, body mass index, and waist circumference of patients compared with the placebo at the end of the study (p < .05 for all). HOMA-IR and triglyceride levels significantly increased within the placebo group. Changes in fasting blood sugar, insulin, other lipids profile, and visfatin levels were not significant in any of the groups (p > .05). These results support the consumption of curcumin, as a part of an integrated approach to modulate metabolic factors, inflammation, and adiposity in women with RA.


Assuntos
Artrite Reumatoide , Curcumina , Resistência à Insulina , Artrite Reumatoide/tratamento farmacológico , Glicemia , Curcumina/farmacologia , Curcumina/uso terapêutico , Suplementos Nutricionais , Método Duplo-Cego , Feminino , Humanos , Masculino , Nicotinamida Fosforribosiltransferase , Obesidade/tratamento farmacológico
8.
IEEE Trans Biomed Eng ; 69(3): 1123-1132, 2022 03.
Artigo em Inglês | MEDLINE | ID: mdl-34550878

RESUMO

OBJECTIVE: Retinal vein cannulation is a technically demanding surgical procedure and its feasibility may rely on using advanced surgical robots equipped with force-sensing microneedles. Reliable detection of the moment of venous puncture is important, to either alert or prevent the clinician from double puncturing the vessel and damaging the retinal surface beneath. This paper reports the first in-vivo retinal vein cannulation trial on rabbit eyes, using sensorized metal needles, and investigates puncture detection. METHODS: We utilized total of four indices including two previously demonstrated ones and two new indices, based on the velocity and force of the needle tip and the correlation between the needle-tissue and tool-sclera interaction forces. We also studied the effect of detection timespan on the performance of detecting actual punctures. RESULTS: The new indices, when used in conjunction with the previous algorithm, improved the detection rate form 75% to 92%, but slightly increased the number of false detections from 37 to 43. Increasing the detection window improved the detection performance, at the cost of adding to the delay. CONCLUSION: The current algorithm can supplement the surgeons' visual feedback and surgical judgment. To achieve automatic puncture detection, more measurements and further analysis are required. Subsequent in-vivo studies in other animals, such as pigs with their more human like eye anatomy, are required, before clinical trials. SIGNIFICANCE: The study provides promising results and the criteria developed may serve as guidelines for further investigation into puncture detection in in-vivo retinal vein cannulation.


Assuntos
Oclusão da Veia Retiniana , Veia Retiniana , Robótica , Animais , Cateterismo/métodos , Agulhas , Punções , Coelhos , Retina , Veia Retiniana/diagnóstico por imagem , Veia Retiniana/cirurgia , Oclusão da Veia Retiniana/diagnóstico , Oclusão da Veia Retiniana/cirurgia , Robótica/métodos , Suínos
9.
Clin Rheumatol ; 41(4): 1033-1044, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-34766228

RESUMO

BACKGROUND: Stachys schtschegleevii (SSC) is a herbal medicine used to treat infections. To date, this is the first study aimed to investigate the effects of SSC tea on disease activity score (DAS), serum inflammatory biomarkers and matrix metalloproteinases (MMP-1 and MMP-3) among women with rheumatoid arthritis (RA). METHODS: This pilot, triple-blind, randomized controlled clinical trial was conducted among forty-four women (age: 30-65 years) diagnosed with moderately active RA. Subjects were randomly assigned (1:1 ratio) into either SSC group (2.4 g/day SSC + 2.4 g/day black tea, n=22) or placebo (2.4 g/day black tea, n=22) for 8 weeks. Serum high-sensitivity C-reactive protein (hs-CRP), interleukin-1 beta (IL-1ß), and MMPs were measured using ELISA. According to the American College of Rheumatology guideline considering hs-CRP, DAS28 was assessed. RESULTS: Both study groups had respondent rates above 94.9%. The SSC intervention caused significant reductions in the number and the percent changes of the tender joints (SSC: -74.39% vs. placebo: -57.15%, mean differences= -0.77; P<0.05) and DAS28 [SSC: -32.44% vs. placebo: -22.32%, mean differences= -0.41, P<0.05). Unlike the intervention within SSC group that showed significant reductions in the mean serum levels of hs-CRP, IL-1ß, and MMP-3, SSC caused significant MMP-3 reductions (SSC: -20.59% vs. placebo: 1.29%, P<0.05). CONCLUSION: The SSC intervention showed an appropriate clinical efficacy for female RA patients, accompanying remarkable reductions in the number of tender and swollen joints, DAS28, and serum levels of MMP-3. This can provide additional insights to the interventional studies controlling RA-related pathological and inflammatory outcomes. Trial registration Prospectively registered at the Iranian Registry of Clinical Trials (IRCT), linked to the WHO Registry Network ( https://en.irct.ir/trial/11602 , IRCT registration number: IRCT2015032011335N5, Registration date:2015-05-12). Key Points • Stachys schtschegleevii improved clinical outcomes and attenuated disease severity in RA patients. • Stachys schtschegleevii ameliorated serum level of MMP-3 in RA patients.


Assuntos
Artrite Reumatoide , Stachys , Adulto , Idoso , Artrite Reumatoide/tratamento farmacológico , Método Duplo-Cego , Feminino , Humanos , Irã (Geográfico) , Metaloproteinase 3 da Matriz , Pessoa de Meia-Idade , Índice de Gravidade de Doença , Chá
10.
J Dermatolog Treat ; 33(2): 699-703, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32598204

RESUMO

BACKGROUND: There is concern about susceptibility of psoriatic patients on biologics to coronavirus disease 2019 (COVID-19) and its clinical course. PURPOSE: The aims of present review were to determine whether the biologic treatment of psoriasis increases the risk of SARS-CoV-2 infection and if biologics affect the clinical course of COVID-19 in these patients. METHODS: We searched database of MEDLINE (PubMed) for key term of psoriasis biologic and COVID-19 until June 9, 2020 and all published 14 papers and an experience from Iran (10509 cases) related to the psoriatic patients on biologics and COVID-19 along with relevant papers were summarized. In spite of limitation in some reports, due to some of strengths that will be discussed, all papers were included in this review. RESULTS: According to 8769 medical reports around 0.3% of psoriatic patients had COVID-19 and the rate of hospitalization was 0.1%. No death due to COVID-19 was reported among 10509 patients. Reports indicated psoriatic patients on biologics were not more susceptible to COVID-19 and the severe clinical course of disease. CONCLUSION: While there is not definitive controlled trial data, the available evidence suggests that patients with psoriasis without COVID-19 can continue the biologic therapy for psoriasis.


Assuntos
Produtos Biológicos , COVID-19 , Psoríase , Produtos Biológicos/uso terapêutico , Terapia Biológica , Humanos , Psoríase/tratamento farmacológico , SARS-CoV-2
11.
Bioelectrochemistry ; 143: 107989, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-34735914

RESUMO

Cell attachment onto electrode-forming biocathodes is a promising alternative to expensive catalysts used for electricity production in bioelectrochemical systems (BESs). Though BESs have been extensively studied for decades, the processes, underlying mechanisms, and determinant driving forces of microalgal biocathode formation remain largely unknown. In this study, we employed a model unicellular motile microalga, Chlamydomonas microsphaera, to investigate the microalgal attachment processes onto the electrode surface of a BES and to identify the determinant factors. Results showed that the initial attachment of C. micrrosphaera cells is determined by the applied external voltage rather than nutrient availability and occurs via electrotaxis-mediated cell motility. The subsequent development of the C. microsphaera biofilm is then increasingly determined by nutrient availability. Our results revealed that, in the absence of an external voltage, nutrient availability remains a dominant factor controlling the fate of the microalgal surface attachment and subsequent biofilm formation processes. Thus, our results show that electrotactic and chemotactic movements are crucial to facilitate the initial attachment and subsequent biofilm formation of C. microsphaera onto the electrode surfaces of BES. This study provides new insights into the mechanisms of microalgal surface attachment and biofilm formation processes on microalgal biocathodes, which hold great promise for improving the electrochemical properties of cathodes.


Assuntos
Fontes de Energia Bioelétrica
12.
Environ Technol ; : 1-12, 2021 Dec 22.
Artigo em Inglês | MEDLINE | ID: mdl-34859742

RESUMO

Microalgal cell attaching and biofilm formation are critical in the application of microalgal biocathode, which severs as one of the hopeful candidates to an original cathode in bioelectrochemical systems. Many efforts have been put in biofilm formation and bioelectrochemical systems for years, but the predominant factors shaping microalgal biocathode formation are sketchy. We launched a pair of researches to investigate microalgal attachment and biofilm formation in the presence/absence of applied voltages using Chlamydomonas microsphaera as a model unicellular motile microalga. In this study, we presented how microalga attached and biofilm formed on a carbon felt surface without applied voltages and try to manifest the most important aspects in this process. Results showed that while nutrient sources did not directly regulate cell attachment onto the carbon felt, limited initial nutrient concentration nevertheless promoted cell attachment. Specifically, nutrient availability did not influence the early stage (20-60 min) of microalgal cell attachment but did significantly impact cell attachment during later stages (240-720 min). Further analysis revealed that nutrient availability-mediated chemotactic movements and zeta potential are crucial to facilitate the initial attachment and subsequent biofilm formation of C. microsphaera onto the surfaces, serving as an important factor controlling microalgal surface attachment. Our results demonstrate that nutrient availability is a dominant factor controlling microalgal surface attachment and subsequent biofilm formation processes. This study provides a mechanistic understanding of microalgal surface attachment and biofilm formation processes on carbon felts surfaces in the absence of applied voltages.

13.
Front Psychiatry ; 12: 744180, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34955912

RESUMO

Autistic traits (ATs) include symptoms associated with autism spectrum conditions (ASCs), which are assumed to be continuously distributed across the general population. Studies have indicated the cultural differences in the expression of ATs. Notwithstanding, our literature review indicated that studies on cross-cultural differences in the expression of ATs included samples from different countries. This is the first study designed to compare the expression of ATs between different ethnicities from the same country. Using the Autism-spectrum Quotient (AQ-28), we examined the possible cultural differences in the expression of autistic traits from four groups of students with different ethnic backgrounds, including Turkish (n = 262), Persian (n = 290), Kurdish (n = 300), and Luri (n = 307) students. Behaviors associated with autistic traits were reported overall higher for males than females. Also, significant cultural differences in autistic traits were found that were different for males and females. Furthermore, while the medical sciences student group scored significantly higher than the humanities group in the Imagination dimension, the humanities group had significantly higher scores in Number/Pattern dimensions than the engineering and medical sciences groups. Altogether, our results provide further support for the idea that the expression of ATs is significantly influenced by culture. A significant limitation of the current study was that groups were not matched with respect to age, percentage of male participants, and fields of studies and that these variables may influence the AQ scores.

14.
BMJ Open ; 11(11): e052663, 2021 11 02.
Artigo em Inglês | MEDLINE | ID: mdl-34728454

RESUMO

OBJECTIVES: This systematic review aimed to assess the performance and clinical feasibility of machine learning (ML) algorithms in prediction of in-hospital mortality for medical patients using vital signs at emergency departments (EDs). DESIGN: A systematic review was performed. SETTING: The databases including Medline (PubMed), Scopus and Embase (Ovid) were searched between 2010 and 2021, to extract published articles in English, describing ML-based models utilising vital sign variables to predict in-hospital mortality for patients admitted at EDs. Critical appraisal and data extraction for systematic reviews of prediction modelling studies checklist was used for study planning and data extraction. The risk of bias for included papers was assessed using the prediction risk of bias assessment tool. PARTICIPANTS: Admitted patients to the ED. MAIN OUTCOME MEASURE: In-hospital mortality. RESULTS: Fifteen articles were included in the final review. We found that eight models including logistic regression, decision tree, K-nearest neighbours, support vector machine, gradient boosting, random forest, artificial neural networks and deep neural networks have been applied in this domain. Most studies failed to report essential main analysis steps such as data preprocessing and handling missing values. Fourteen included studies had a high risk of bias in the statistical analysis part, which could lead to poor performance in practice. Although the main aim of all studies was developing a predictive model for mortality, nine articles did not provide a time horizon for the prediction. CONCLUSION: This review provided an updated overview of the state-of-the-art and revealed research gaps; based on these, we provide eight recommendations for future studies to make the use of ML more feasible in practice. By following these recommendations, we expect to see more robust ML models applied in the future to help clinicians identify patient deterioration earlier.


Assuntos
Serviço Hospitalar de Emergência , Aprendizado de Máquina , Hospitalização , Humanos , Modelos Logísticos , Revisões Sistemáticas como Assunto
15.
Artigo em Inglês | MEDLINE | ID: mdl-34772468

RESUMO

BACKGROUND: Non-suicidal self-injury (NSSI) is a serious public health problem prevalent among adolescents and young adults. The present study examines the factor structure, internal consistency, and validity of the Persian version of the Inventory of Statements About Self-injury (ISAS), a self-report measure designed to comprehensively assess non-suicidal self-injury (NSSI). METHODS: A total of 655 Iranian school-attending adolescents completed study measures online, and 246 youth (37.70 %) (M age = 15.38, SD ± 0.50; 53 % female) reported a history of NSSI at least once during their lifetime. RESULTS: Confirmatory factor analysis supported the proposed two-factor model of ISAS (i.e., Interpersonal and Intrapersonal dimensions), which were internally consistent and yielded direct associations with converging correlates (e.g., depression, anxiety, irritability, and anger). CONCLUSIONS: Findings indicated that the Persian version of the ISAS has sound psychometric properties and is a valid and reliable self-report measure of NSSI.

16.
BMC Med Inform Decis Mak ; 21(1): 298, 2021 10 30.
Artigo em Inglês | MEDLINE | ID: mdl-34749708

RESUMO

BACKGROUND: Prediction of length of stay (LOS) at admission time can provide physicians and nurses insight into the illness severity of patients and aid them in avoiding adverse events and clinical deterioration. It also assists hospitals with more effectively managing their resources and manpower. METHODS: In this field of research, there are some important challenges, such as missing values and LOS data skewness. Moreover, various studies use a binary classification which puts a wide range of patients with different conditions into one category. To address these shortcomings, first multivariate imputation techniques are applied to fill incomplete records, then two proper resampling techniques, namely Borderline-SMOTE and SMOGN, are applied to address data skewness in the classification and regression domains, respectively. Finally, machine learning (ML) techniques including neural networks, extreme gradient boosting, random forest, support vector machine, and decision tree are implemented for both approaches to predict LOS of patients admitted to the Emergency Department of Odense University Hospital between June 2018 and April 2019. The ML models are developed based on data obtained from patients at admission time, including pulse rate, arterial blood oxygen saturation, respiratory rate, systolic blood pressure, triage category, arrival ICD-10 codes, age, and gender. RESULTS: The performance of predictive models before and after addressing missing values and data skewness is evaluated using four evaluation metrics namely receiver operating characteristic, area under the curve (AUC), R-squared score (R2), and normalized root mean square error (NRMSE). Results show that the performance of predictive models is improved on average by 15.75% for AUC, 32.19% for R2 score, and 11.32% for NRMSE after addressing the mentioned challenges. Moreover, our results indicate that there is a relationship between the missing values rate, data skewness, and illness severity of patients, so it is clinically essential to take incomplete records of patients into account and apply proper solutions for interpolation of missing values. CONCLUSION: We propose a new method comprised of three stages: missing values imputation, data skewness handling, and building predictive models based on classification and regression approaches. Our results indicated that addressing these challenges in a proper way enhanced the performance of models significantly, which led to a more valid prediction of LOS.


Assuntos
Serviço Hospitalar de Emergência , Triagem , Hospitalização , Humanos , Tempo de Internação , Aprendizado de Máquina
17.
Front Psychiatry ; 12: 760531, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34795601

RESUMO

The self-report version of the Antisocial Process Screening Device (APSD) is a commonly used tool for assessing psychopathic traits in youth. This is the first study designed to examine the factor structure, internal consistency, and convergent validity of the Persian APSD-SR in a sample of 675 school-attending youth in Iran (46% girls; M age = 16.35). Confirmatory factor analysis supported a modified three-factor model, with items loading on narcissism, callous-unemotional, and impulsivity dimensions, which was invariant across gender. Notwithstanding that the internal consistency of some APSD scores was unsatisfactory, the APSD total and dimension scores showed the expected relations with external correlates (e.g., conduct problems, aggression, and low prosocial behavior), supporting the validity of the interpretation of the APSD scores. The findings showed that the APSD is a useful tool for assessing psychopathic traits in Iranian adolescents and may spark research on adolescent psychopathy in mental health and forensic settings.

18.
Iran J Otorhinolaryngol ; 33(118): 257-262, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34692572

RESUMO

INTRODUCTION: The clinicopathological characteristics of basal cell carcinoma (BCC) in different areas of the face, including the nose, are important and may be different. Accurate recognition of these characteristics may be necessary for the planning and selection of appropriate treatment. MATERIALS AND METHODS: This cross-sectional study was conducted on 328 patients (131 females and 197 males) with 371 documented facial BCC in the West of Iran within 2013-2018. The demographic and clinicopathological data of the patients in the nose area were compared with other sites of the face by appropriate statistical methods. RESULTS: Out of 371 lesions, 38.8% of the cases were on the nose, 75.8% were primary lesions, 97.8% had no perineural invasion, 89.2% were nodular, and 65.8% were of nodular clinical and pathologic type, which were the most common variables of patients. It was revealed that early-onset (P<0.001), smaller size (P<0.001), high-risk pathologic type (P=0.01), and recurrent lesions (P=0.013) were significantly higher in the nasal BCC. However, there was no significant difference between BCC in the nose and other sites of the face in terms of gender (P=0.654), high-risk clinical type (P=0.06), and perineural invasion (P=0.275). CONCLUSION: Considering the nasal site as an important cosmetic unit, more limitation of the nose in performing any procedure, and presence of the more risk factors in the nose than in other areas of the face, the definite treatment of nasal BCC requires special attention, expertise, and experience.

19.
Front Cell Dev Biol ; 9: 717587, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34540833

RESUMO

Currently, the COVID-19 pandemic is an international challenge, largely due to lack of effective therapies. Pharmacotherapy has not yet been able to find a definitive treatment for COVID-19. Since SARS-CoV-2 affects several organs, treatment strategies that target the virus in a wider range are expected to be ultimately more successful. To this end, a two-step treatment strategy has been presented. In the first phase of the disease, when the patient is newly infected with the virus and the cytokine storm has not yet been developed, a chimeric peptide is used to inhibit virus entry into the host cell cytosol (by inhibiting endosomal pH acidification) and viral replication. After the virus entry and decrease of angiotensin converting enzyme 2 (ACE2) level, some people are unable to properly compensate for the ACE2 pathway and progress toward the cytokine storm. In the beginning of the cytokine storm, sACE2 protein is very effective in regulating the immune system toward the anti-inflammatory pathway, including M2 macrophages. Hence, the genes of 8P9R chimeric peptide and sACE2 would be inserted in an episomal vector with a separate promoter for each gene: the chimeric peptide gene promoter is a CMV promoter, while the sACE2 gene promoter is a NF-κB-sensitive promoter. The NF-κB-sensitive promoter induces the expression of sACE2 gene soon after elevation of NF-κB which is the main transcription factor of inflammatory genes. Thus, as the expression of inflammatory cytokines increases, the expression of sACE2 increases simultaneously. In this condition, sACE2 can prevent the cytokine storm by inhibiting the pro-inflammatory pathways. To deliver the designed vector to the target cells, mesenchymal stem cell-derived (MSC-derived) exosome-liposome hybrids are used. Herein, the strategy can be considered as a personalized clinical therapy for COVID-19, that can prevent morbidity and mortality in the future.

20.
Artigo em Inglês | MEDLINE | ID: mdl-34565123

RESUMO

INTRODUCTION: Vitiligo is a disease with a high prevalence and burden that has a negative impact on various aspects of life. Because most cases of vitiligo are not responsive to medical treatment, we performed simplified autologous melanocyte and keratinocyte grafting to treat refractory stable vitiligo. METHODS: This interventional study was carried out on 32 patients (16 females and 16 males). After local anesthesia at the donor site, we shaved the donor sites to harvest autologous melanocyte material. The harvested paste-like non-trypsinized material was spread over the abraded recipient area. Patient follow-up was performed to track the treatment outcome and possible complications. RESULTS: Out of 32 patients with 99 lesions, the generalized type accounted for 28 (87.5%) patients, and 46 (46.5%) lesions were seen in the upper extremity as the most common clinical type and site of involvement. Eighteen (18.2%) and 26 (26.3%) patches showed excellent and good re-pigmentation, respectively, and face areas showed significantly better re-pigmentation (p < 0.001). CONCLUSIONS: Simplified autologous melanocyte and keratinocyte grafting is a safe, simple, office-based, and low-cost procedure with a modest re-pigmentation outcome in refractory stable vitiligo. Moreover, the face area had a satisfactory outcome with this procedure.


Assuntos
Vitiligo , Feminino , Humanos , Queratinócitos , Masculino , Melanócitos , Pigmentação da Pele , Resultado do Tratamento , Vitiligo/cirurgia
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