Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 76
Filtrar
Filtros adicionais











Tipo de estudo
País/Região como assunto
Intervalo de ano
1.
An Bras Dermatol ; 94(3): 264-278, 2019 Jul 29.
Artigo em Inglês | MEDLINE | ID: mdl-31365654

RESUMO

Pemphigus vulgaris is a chronic autoimmune bullous dermatosis that results from the production of autoantibodies against desmogleins 1 and 3. It is the most frequent and most severe form of pemphigus, occurring universally, usually between 40 and 60 years of age. It usually begins with blisters and erosions on the oral mucosa, followed by lesions on other mucous membranes and flaccid blisters on the skin, which can be disseminated. There is a clinical variant, pemphigus vegetans, which is characterized by the presence of vegetating lesions in the large folds of the skin. Clinical suspicion can be confirmed by cytological examination, histopathological examination, and direct and indirect immunofluorescence tests. The treatment is performed with systemic corticosteroids, and immunosuppressive drugs may be associated, among them azathioprine and mycophenolate mofetil. More severe cases may benefit from corticosteroids in the form of intravenous pulse therapy, and recent studies have shown a beneficial effect of rituximab, an anti-CD20 immunobiological drug. It is a chronic disease with mortality around 10%, and septicemia is the main cause of death. Patients need long-term and multidisciplinary follow-up.


Assuntos
Pênfigo/diagnóstico , Adulto , Autoanticorpos/imunologia , Desmossomos/imunologia , Diagnóstico Diferencial , Feminino , Humanos , Imunoglobulinas Intravenosas/uso terapêutico , Imunossupressores/classificação , Imunossupressores/uso terapêutico , Imunoterapia/métodos , Masculino , Pessoa de Meia-Idade , Pênfigo/classificação , Pênfigo/epidemiologia , Pênfigo/terapia , Pele/patologia , Inquéritos e Questionários
2.
An. bras. dermatol ; 94(3): 264-278, May-June 2019. tab, graf
Artigo em Inglês | LILACS-Express | ID: biblio-1011108

RESUMO

Abstract: Pemphigus vulgaris is a chronic autoimmune bullous dermatosis that results from the production of autoantibodies against desmogleins 1 and 3. It is the most frequent and most severe form of pemphigus, occurring universally, usually between 40 and 60 years of age. It usually begins with blisters and erosions on the oral mucosa, followed by lesions on other mucous membranes and flaccid blisters on the skin, which can be disseminated. There is a clinical variant, pemphigus vegetans, which is characterized by the presence of vegetating lesions in the large folds of the skin. Clinical suspicion can be confirmed by cytological examination, histopathological examination, and direct and indirect immunofluorescence tests. The treatment is performed with systemic corticosteroids, and immunosuppressive drugs may be associated, among them azathioprine and mycophenolate mofetil. More severe cases may benefit from corticosteroids in the form of intravenous pulse therapy, and recent studies have shown a beneficial effect of rituximab, an anti-CD20 immunobiological drug. It is a chronic disease with mortality around 10%, and septicemia is the main cause of death. Patients need long-term and multidisciplinary follow-up.

3.
J Dermatol ; 46(7): 618-621, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31144726

RESUMO

Eosinophilic dermatosis of hematological malignancy is a paraneoplastic skin eruption associated with chronic lymphocytic leukemia and other B-cell malignancies. It clinically resembles an insect bite reaction and it can precede the symptoms of the hematological malignancy or be related to a more aggressive course. Different treatments have been proposed, but partial response and recurrence are frequent. Herein, we describe a case of eosinophilic dermatosis associated with mantle cell lymphoma with remission after lenalidomide therapy.

4.
An. bras. dermatol ; 94(1): 29-36, Jan.-Feb. 2019. graf
Artigo em Inglês | LILACS-Express | ID: biblio-983752

RESUMO

Abstract: Background: Diseases caused by melanized fungi include mycetoma, chromoblastomycosis and phaeohyphomycosis. This broad clinical spectrum depends on the dynamic interactions between etiologic agent and host. The immune status of the host influences on the development of the disease, as, an exemple. phaeohyphomicosis is more frequently observed in immunocompromised patients. Objectives: Examine the histological inflammatory response induced by Fonsecaea pedrosoi in several different strains of mice (BALB/c, C57BL/6, Nude and SCID, and reconstituted Nude). Methods: Fonsecaea pedrosoi was cultivated on agar gel and a fragment of this gel was implanted subcutaneously in the abdominal region of female adult mice. After infection has been obtained, tissue fragment was studied histopathologically. Results: There were significant changes across the strains, with the nodular lesion more persistent in Nude and SCID mice, whereas in immunocompetent mice the lesion progressed to ulceration and healing. The histopathological analysis showed a significant acute inflammatory reaction which consisted mainly of neutrophils in the initial phase that was subsequently followed by a tuberculoid type granuloma in immunocompetent mice. Study limitations: There is no a suitable animal model for chromoblastomycosis. Conclusions: The neutrophilic infiltration had an important role in the containment of infection to prevent fungal spreading, including in immunodeficient mice. The fungal elimination was dependent on T lymphocytes. The re-exposure of C57BL/6 mice to Fonsecaea pedrosoi caused a delay in resolving the infection, and appearance of muriform cells, which may indicate that re-exposure to fungi, might lead to chronicity of infection.

5.
An Bras Dermatol ; 94(1): 29-36, 2019 Jan-Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30726460

RESUMO

BACKGROUND: Diseases caused by melanized fungi include mycetoma, chromoblastomycosis and phaeohyphomycosis. This broad clinical spectrum depends on the dynamic interactions between etiologic agent and host. The immune status of the host influences on the development of the disease, as, an exemple. phaeohyphomicosis is more frequently observed in immunocompromised patients. OBJECTIVES: Examine the histological inflammatory response induced by Fonsecaea pedrosoi in several different strains of mice (BALB/c, C57BL/6, Nude and SCID, and reconstituted Nude). METHODS: Fonsecaea pedrosoi was cultivated on agar gel and a fragment of this gel was implanted subcutaneously in the abdominal region of female adult mice. After infection has been obtained, tissue fragment was studied histopathologically. RESULTS: There were significant changes across the strains, with the nodular lesion more persistent in Nude and SCID mice, whereas in immunocompetent mice the lesion progressed to ulceration and healing. The histopathological analysis showed a significant acute inflammatory reaction which consisted mainly of neutrophils in the initial phase that was subsequently followed by a tuberculoid type granuloma in immunocompetent mice. STUDY LIMITATIONS: There is no a suitable animal model for chromoblastomycosis. CONCLUSIONS: The neutrophilic infiltration had an important role in the containment of infection to prevent fungal spreading, including in immunodeficient mice. The fungal elimination was dependent on T lymphocytes. The re-exposure of C57BL/6 mice to Fonsecaea pedrosoi caused a delay in resolving the infection, and appearance of muriform cells, which may indicate that re-exposure to fungi, might lead to chronicity of infection.


Assuntos
Ascomicetos , Dermatomicoses/imunologia , Imunocompetência , Inflamação/imunologia , Inflamação/microbiologia , Animais , Contagem de Células Sanguíneas , Cromoblastomicose/imunologia , Cromoblastomicose/patologia , Doença Crônica , Dermatomicoses/patologia , Modelos Animais de Doenças , Feminino , Inflamação/patologia , Camundongos Endogâmicos BALB C , Camundongos Endogâmicos C57BL , Camundongos Nus , Camundongos SCID , Neutrófilos , Especificidade da Espécie , Fatores de Tempo
6.
An. bras. dermatol ; 93(5): 726-729, Sept.-Oct. 2018. tab, graf
Artigo em Inglês | LILACS-Express | ID: biblio-949959

RESUMO

Abstract: Fusariosis is due to inhalation or direct contact with conidia. Clinical presentation depends on host's immunity and can be localized, focally invasive or disseminated. Given the severity of this infection and the possibility for the dermatologist to make an early diagnosis, we report six cases of patients with hematologic malignancies, who developed febrile neutropenia an skin lesions suggestive of cutaneous fusariosis. All patients had skin cultures showing growth of Fusarium solani complex, and they received amphotericin B and voriconazole. As this infection can quickly lead to death, dermatologists play a crucial role in diagnosing this disease.

7.
An Bras Dermatol ; 93(5): 726-729, 2018 Sep-Oct.
Artigo em Inglês | MEDLINE | ID: mdl-30156626

RESUMO

Fusariosis is due to inhalation or direct contact with conidia. Clinical presentation depends on host's immunity and can be localized, focally invasive or disseminated. Given the severity of this infection and the possibility for the dermatologist to make an early diagnosis, we report six cases of patients with hematologic malignancies, who developed febrile neutropenia an skin lesions suggestive of cutaneous fusariosis. All patients had skin cultures showing growth of Fusarium solani complex, and they received amphotericin B and voriconazole. As this infection can quickly lead to death, dermatologists play a crucial role in diagnosing this disease.


Assuntos
Fusariose/complicações , Fusarium/isolamento & purificação , Leucemia Mieloide Aguda/complicações , Mieloma Múltiplo/complicações , Leucemia-Linfoma Linfoblástico de Células Precursoras/complicações , Pele/microbiologia , Adulto , Antifúngicos/uso terapêutico , Evolução Fatal , Fusariose/patologia , Fusariose/prevenção & controle , Humanos , Pessoa de Meia-Idade , Neutropenia/etiologia , Pele/patologia , Adulto Jovem
8.
An Bras Dermatol ; 93(3): 435-437, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29924252

RESUMO

Linear immunoglobulin A bullous dermatosis is a rare autoimmune disease that usually has an excellent prognosis in childhood; however, its control is more difficult in adults. It presents heterogeneous clinical manifestations and is frequently confused with other bullous diseases such as bullous pemphigoid and Duhring's dermatitis herpetiformis. Dermatologists' awareness of this disease contributes to early diagnosis and appropriate treatment. We thus report three cases of linear immunoglobulin A dermatosis in adults.


Assuntos
Dermatose Linear Bolhosa por IgA/diagnóstico , Dermatopatias Vesiculobolhosas/diagnóstico , Adulto , Diagnóstico Precoce , Feminino , Técnica Direta de Fluorescência para Anticorpo , Humanos , Dermatose Linear Bolhosa por IgA/patologia , Masculino , Pessoa de Meia-Idade , Doenças Raras , Dermatopatias Vesiculobolhosas/patologia
9.
An. bras. dermatol ; 93(3): 435-437, May-June 2018. graf
Artigo em Inglês | LILACS-Express | ID: biblio-949900

RESUMO

Abstract: Linear immunoglobulin A bullous dermatosis is a rare autoimmune disease that usually has an excellent prognosis in childhood; however, its control is more difficult in adults. It presents heterogeneous clinical manifestations and is frequently confused with other bullous diseases such as bullous pemphigoid and Duhring's dermatitis herpetiformis. Dermatologists' awareness of this disease contributes to early diagnosis and appropriate treatment. We thus report three cases of linear immunoglobulin A dermatosis in adults.

10.
An Bras Dermatol ; 93(2): 274-276, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29723351

RESUMO

Lupus erythemathosus is a chronic, relapsing disease with acute, subacute, and chronic lesions. Effluvium telogen occurs in the setting of systemic activity of the disease, and cicatricial alopecia results from discoid lesionsin on the scalp. Other types of alopecia, like alopecia areata, may rarely be found in lupus. Frontal fibrosing alopecia is characterized by frontotemporal hairline recession and eybrow loss. Histophatologically, it cannot be differentiated from lichen planopilaris.It is controversial whether frontal fibrosing alopecia is a subtype of lichen planopilaris.. A pacient with chronic lichenoid lupus erythematosus is described with clinical, histophatological and dermoscopic features of frontal fibrosing alopecia.We have not been able to find in the literature cases of frontal fibrosing alopecia as a clinical manifestation of lupus.


Assuntos
Alopecia/complicações , Alopecia/patologia , Lúpus Eritematoso Discoide/complicações , Lúpus Eritematoso Discoide/patologia , Biópsia , Dermoscopia , Feminino , Fibrose/patologia , Humanos , Erupções Liquenoides/patologia , Pessoa de Meia-Idade , Couro Cabeludo/patologia
11.
An. bras. dermatol ; 93(2): 274-276, Mar.-Apr. 2018. graf
Artigo em Inglês | LILACS-Express | ID: biblio-887172

RESUMO

Abstract: Lupus erythemathosus is a chronic, relapsing disease with acute, subacute, and chronic lesions. Effluvium telogen occurs in the setting of systemic activity of the disease, and cicatricial alopecia results from discoid lesionsin on the scalp. Other types of alopecia, like alopecia areata, may rarely be found in lupus. Frontal fibrosing alopecia is characterized by frontotemporal hairline recession and eybrow loss. Histophatologically, it cannot be differentiated from lichen planopilaris.It is controversial whether frontal fibrosing alopecia is a subtype of lichen planopilaris.. A pacient with chronic lichenoid lupus erythematosus is described with clinical, histophatological and dermoscopic features of frontal fibrosing alopecia.We have not been able to find in the literature cases of frontal fibrosing alopecia as a clinical manifestation of lupus.

12.
An Bras Dermatol ; 92(5 Suppl 1): 69-72, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-29267451

RESUMO

Cryptococcosis is a common fungal infection in immunocompromised patients, caused by genus Cryptococcus, presenting with meningitis, pneumonia, and skin lesions. Cutaneous presentation can be varied, but specifically in solid organ transplant recipients (iatrogenically immunocompromised), cryptococcosis should always be considered in the differential diagnosis of cellulitis-like lesions, since the delay in diagnosis leads to worse prognosis and fatal outcome. We report four cases of cryptococcosis with cutaneous manifestation not only for its rarity, but also to emphasize the important role of the dermatologist in the diagnosis of this disease.


Assuntos
Criptococose/patologia , Dermatomicoses/patologia , Adulto , Antifúngicos/uso terapêutico , Biópsia , Criptococose/tratamento farmacológico , Criptococose/imunologia , Dermatomicoses/tratamento farmacológico , Dermatomicoses/imunologia , Diagnóstico Diferencial , Humanos , Imunocompetência , Masculino , Pessoa de Meia-Idade , Pele/patologia
13.
An Bras Dermatol ; 92(5 Suppl 1): 129-131, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-29267470

RESUMO

Pyoderma gangrenosum is a rare neutrophilic dermatosis of unknown etiology, of which the most frequent clinical manifestations are ulcers. The diagnosis difficulty is, among other things, to rule out other causes of ulcers, since it is considered a diagnosis of exclusion. Skin ulcerations may also occur in the iliac vein compression syndrome, which, like pyoderma gangrenosum, mainly affects young women. Because they have such similar characteristics, the presence of vascular disease may hinder the diagnosis of concurrent pyoderma gangrenosum. Because of the clinical relevance of ulcerated lesions and scars, the early diagnosis and treatment of this condition is considered extremely important. We report a case in which the two diseases were associated, hampering the diagnosis of pyoderma gangrenosum.


Assuntos
Síndrome de May-Thurner/complicações , Pioderma Gangrenoso/etiologia , Pioderma Gangrenoso/patologia , Biópsia , Diagnóstico Diferencial , Feminino , Humanos , Pessoa de Meia-Idade
16.
An Bras Dermatol ; 92(4): 546-549, 2017 Jul-Aug.
Artigo em Inglês | MEDLINE | ID: mdl-28954109

RESUMO

Liposarcomas correspond to the most common histological subtype of soft tissue sarcomas. They can be subdivided into: well differentiated or atypical lipoma, undifferentiated, myxoid, round, and pleomorphic cells. Atypical lipomas are the most prevalent and usually appear as asymptomatic softened tumors. They are locally aggressive but rarely lead to distant metastases. The diagnosis of this tumor is based on the imaging and histopathologic findings. Treatment consists of excision surgery with complete tumor removal. It has a good prognosis due to the low percentage of distant metastases. We report a rare case of giant atypical lipoma as well as the adopted therapy and evolution.


Assuntos
Lipoma/patologia , Lipossarcoma/patologia , Neoplasias de Tecidos Moles/patologia , Adulto , Biópsia , Nádegas/patologia , Diagnóstico Diferencial , Humanos , Lipoma/diagnóstico , Lipoma/cirurgia , Lipossarcoma/diagnóstico , Lipossarcoma/cirurgia , Masculino , Neoplasias de Tecidos Moles/diagnóstico , Neoplasias de Tecidos Moles/cirurgia
18.
An. bras. dermatol ; 92(4): 546-549, July-Aug. 2017. tab, graf
Artigo em Inglês | LILACS-Express | ID: biblio-886990

RESUMO

Abstract: Liposarcomas correspond to the most common histological subtype of soft tissue sarcomas. They can be subdivided into: well differentiated or atypical lipoma, undifferentiated, myxoid, round, and pleomorphic cells. Atypical lipomas are the most prevalent and usually appear as asymptomatic softened tumors. They are locally aggressive but rarely lead to distant metastases. The diagnosis of this tumor is based on the imaging and histopathologic findings. Treatment consists of excision surgery with complete tumor removal. It has a good prognosis due to the low percentage of distant metastases. We report a rare case of giant atypical lipoma as well as the adopted therapy and evolution.

20.
An Bras Dermatol ; 92(1): 124-125, 2017 Jan-Feb.
Artigo em Inglês | MEDLINE | ID: mdl-28225972

RESUMO

Pigmented Bowen's disease is a rare subtype of Bowen's disease. Clinically it presents as a slow-growing, well-defined, hyperpigmented plaque, and should be included as a differential diagnosis of other pigmented lesions. The authors describe a challenging case of pigmented Bowen's disease with non-diagnostic dermscopy findings.


Assuntos
Doença de Bowen/patologia , Carcinoma de Células Escamosas/patologia , Transtornos da Pigmentação/patologia , Neoplasias Cutâneas/patologia , Idoso , Nádegas , Diagnóstico Diferencial , Feminino , Humanos
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA