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1.
Int J Periodontics Restorative Dent ; 40(4): e179-e187, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32559046

RESUMO

The aim of this study was to test the nano-hydroxyapatite powder decontamination method on intraorally contaminated titanium discs and to compare this method with current decontamination methods in the treatment of peri-implantitis. Contaminated discs were assigned to six treatment groups (n = 10 each): titanium hand curette; ultrasonic scaler with a plastic tip (appropriate for titanium); ultrasonic scaler with a plastic tip (appropriate for titanium) + H2O2; short-term airflow system (nano-hydroxyapatite airborne-particle abrasion for 30 seconds); long-term airflow system (nano-hydroxyapatite airborne-particle abrasion for 120 seconds); Er:YAG laser (120 mJ/pulse at 10 Hz). There were also two control groups (n = 10 each): contaminated disc (negative control) and sterile disc (positive control). Scanning electron microscopy, energy-dispersive x-ray spectroscopy, and dynamic contact angle analysis were used to determine the most effective surface-treatment method. The highest percentage of carbon (C) atoms was observed in the negative control group, and the lowest percentage of C atoms was found in the long-term airflow group, followed by the short-term airflow, laser, ultrasonic + H2O2, ultrasonic, and mechanical groups. When the groups were examined for wettability, the lowest contact angle degree was observed in the long-term airflow, short-term airflow, and laser groups. Nano-hydroxyapatite and laser treatments for detoxifying and improving infected titanium surfaces may show the most suitable results for reosseointegration.


Assuntos
Implantes Dentários , Titânio , Durapatita , Peróxido de Hidrogênio , Microscopia Eletrônica de Varredura , Propriedades de Superfície
2.
Clin Oral Investig ; 24(6): 2121-2127, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32430775

RESUMO

OBJECTIVES: The aim of this split-mouth, prospective controlled study was to compare the effects of two different interdental devices on clinical plaque elimination, gingival bleeding and patient acceptance and comfort. MATERIALS AND METHODS: Thirty participants who had been diagnosed with gingivitis were included in the study. After professional oral prophylaxis and a 3-day washout period, patients were advised to use two test devices (TePe Interdental Brushes Original and TePe EasyPick™, Malmö, Sweden) according to instructions. The plaque index (Turesky modification of the Quigley and Hein Index) and bleeding index (Papillary Bleeding Index) were recorded at baseline and after 2 weeks. Patient satisfaction and comfort were assessed with a questionnaire. RESULTS: Both of the tested devices improved the plaque and bleeding index scores. There were no differences between the two sides in terms of time-dependent changes. The patients felt more satisfied with the cleansing capacity and more comfortable with the use of SCIP compared with IDB (p = 0.001). Pain sensation with the use of SCIP was significantly lower than with IDB (p = 0.002). CONCLUSION: The clinical efficiency of the tested interdental devices was similar in terms of removing plaque and decreasing bleeding. However, SCIP were found to be more comfortable and preferable to IDB. CLINICAL RELEVANCE: The silicone coated interdental picks showed similar effects on plaque removal as interdental brushes and superiority in terms of ease to use than interdental brushes.


Assuntos
Dispositivos para o Cuidado Bucal Domiciliar , Gengivite , Silicones , Índice de Placa Dentária , Gengivite/prevenção & controle , Humanos , Aceitação pelo Paciente de Cuidados de Saúde , Estudos Prospectivos , Método Simples-Cego , Suécia , Escovação Dentária , Resultado do Tratamento
3.
Artigo em Inglês | MEDLINE | ID: mdl-33441277

RESUMO

INTRODUCTION: Facial nerve damage is a condition that causes functional, psychological, and cosmetic problems; and treatment methods need to be improved. OBJECTIVE: We investigated the efficacy of titanium-prepared platelet-rich fibrin as a healing enhancer at the region of transection of the facial nerve. METHODS: Twenty-seven New Zealand male rabbits were used in this study, divided into three experimental groups. Group 1, the sham group (n=7); Group 2, the suture group (n=10); and Group 3, the suture+T-PRF group (n=10). In Group 1, the facial nerve trunk was dissected, and no additional surgical intervention was performed. For Group 2, a transection was made to the facial nerve trunk and the nerve endings were sutured together. In Group 3, nerve endings were sutured after transection, and a titanium-prepared platelet-rich fibrin membrane was wrapped in a tube around the damaged area. All animals were followed up weekly for the presence of corneal reflex, whisker movement and low ears. Bilateral facial electromyography was performed both preoperatively and postoperatively at the 1st, 3rd, 5th, 7th, 10th weeks. Tissue samples obtained at the 10th week were histopathologically examined, and intra-group and inter-group comparisons were performed. RESULTS: Subjects in Group showed improvement in whisker movement and ear drop one week earlier than Group 2. In Group 3, the nerve stimulation threshold required to trigger the compound muscle action potential had returned to values similar to the preoperative control values (11.31±2.16V) by 5 weeks postoperatively (12.51±3.97V), (p=0.249). CONCLUSION: Titanium-prepared platelet-rich fibrin administration contributed to partial nerve healing both on a functional and an electrophysiological level.

4.
Clin Oral Investig ; 22(3): 1345-1354, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-28990126

RESUMO

OBJECTIVE: Titanium-prepared platelet-rich fibrin (T-PRF) is activated with titanium, which results in a more mature and aggregated form than PRF. In our previous studies, we established that the fibrin carpet formed with titanium had a firmer network structure, and longer resorption time in the tissue than the fibrin carpet formed with glass. The purpose of this randomized controlled clinical trial is to compare the effects of autogenous T-PRF and connective tissue graft (CTG). MATERIALS AND METHODS: A total of 114 Miller Class I/II gingival recessions with abrasion defects were treated either T-PRF (63 teeth) or CTG (51 teeth) using a modified tunnel technique. Clinical periodontal indexes, keratinized tissue (KTW), gingival thickness, and recession depth were recorded before surgery and at 6- and 12-month follow-up examinations. The visual analog scale and healing index scores were assessed. RESULTS: The mean root coverages were 93.29 and 93.22% in the T-PRF and CTG groups, respectively, at 12 months post-operatively. CTG resulted in greater gingival thickness than T-PRF at 6 and 12 months post-surgery compared to baseline. Furthermore, the mean amounts of KTW increased by 1.97 and 0.75 mm in the T-PRF and CTG groups, respectively. CONCLUSION: Within the limits of this study, the results demonstrated that T-PRF is safe and effective for treatment of multiple Miller Class I/II gingival recession defects. CLINICAL RELEVANCE: T-PRF can serve as a good autogenous alternative to CTG, which is the gold standard for root coverage.


Assuntos
Retração Gengival/cirurgia , Fibrina Rica em Plaquetas , Titânio/farmacologia , Adulto , Idoso , Tecido Conjuntivo/transplante , Feminino , Gengiva/transplante , Humanos , Masculino , Pessoa de Meia-Idade , Índice Periodontal , Estudos Prospectivos , Resultado do Tratamento , Cicatrização
5.
Photomed Laser Surg ; 35(4): 223-230, 2017 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-28092488

RESUMO

OBJECTIVE: The aim of this study was to determine the effects of low-level laser therapy (LLLT) on wound healing at free gingival graft (FGG) donor sites. MATERIALS AND METHODS: Forty patients requiring FGG were selected for this randomized, controlled, and double-blinded prospective clinical trial. The FGG donor sites were treated with LLLT and compared with an untreated control group. The Wound-Healing Index (WHI), tissue consistency, color match, and H2O2 bubbling test for the evaluation of complete wound epithelialization were recorded on the 3rd, 7th, 14th and 21st days. The pain-burning level, number of analgesics, and bleeding were recorded for 7 days. Donor area soft tissue thickness (TT) was measured at baseline and at the first month. RESULTS: The prevalence of Complete Wound Epithelization was higher in the LLLT group than in the control group on the 14th day (p < 0.001). The bleeding was lower in the test group than in the control group during the first 2 days (p ≤ 0.001). Higher WHI Scores were observed in the test group relative to the control group at all visits (p ≤ 0.001). Color match scores were higher in the test group than in the control group at the first 3 visits (p < 0.05). The TT changed from 4.62 ± 0.79 to 4.71 ± 0.82 mm in the LLLT group and from 4.23 ± 0.62 to 4.01 ± 0.68 mm in the control group. CONCLUSIONS: It can be concluded that LLLT enhances FGG donor site wound healing and preserves TT at palatinal donor sites.


Assuntos
Retalhos de Tecido Biológico/transplante , Gengiva/transplante , Terapia com Luz de Baixa Intensidade/métodos , Sítio Doador de Transplante/efeitos da radiação , Cicatrização/efeitos da radiação , Adulto , Cicatriz/prevenção & controle , Feminino , Gengiva/cirurgia , Humanos , Masculino , Estudos Prospectivos , Valores de Referência , Estatísticas não Paramétricas , Transplante Autólogo/métodos , Cicatrização/fisiologia
6.
Acta Odontol Scand ; 74(7): 558-564, 2016 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-27538770

RESUMO

OBJECTIVE: We aimed to determine the clinical effects of titanium-prepared, platelet-rich fibrin (T-PRF) on human palatal mucosal wound healing (PMWH) and to identify its effect on time-dependent changes in palatal soft-tissue thickness (PSTT) in terms of histoconduction, which is a new concept. MATERIALS AND METHODS: Free gingival graft (FGG) donor sites were treated with T-PRF and compared with an untreated control group. The results of colour match and H2O2-bubbling tests for complete wound epithelization (CWE) were recorded on days 3, 7, 14 and 21. Pain level, number of analgesics used and bleeding status were recorded for the first 7 days. PSTT was measured at baseline and after 1 and 6 months. RESULTS: Colour match scores of the test group were significantly higher than those of the control group at 7 and 14 days. CWE was observed at a higher frequency in the test group than in the control group on day 14. Post-operative bleeding prevalence was lower in the test group than in the control group for the first 2 days. A time-dependent decrease in PSTT was observed at 1 and 6 months in the control group compared with baseline (baseline, 4.23 ± 0.62 mm; 1 month, 4.01 ± 0.68 mm; and 6 months, 3.93 ± 0.69 mm). However, no significant difference was found in the test group (baseline, 4.29 ± 0.64 mm; 1 month, 4.61 ± 0.51 mm; and 6 months, 4.51 ± 0.58 mm). CONCLUSION: The T-PRF membrane exhibited positive effects on PMWH. T-PRF, which is a promising autogenous matrix for histoconduction, may also be preferred as an autogenous alternative to connective tissue grafts in the treatment of gingival recessions and peri-implant mucosal recessions.


Assuntos
Materiais Biocompatíveis/química , Plaquetas/fisiologia , Fibrina/uso terapêutico , Gengiva/transplante , Titânio/química , Sítio Doador de Transplante/patologia , Analgésicos/uso terapêutico , Cor , Tecido Conjuntivo/efeitos dos fármacos , Tecido Conjuntivo/patologia , Tecido Conjuntivo/transplante , Seguimentos , Gengiva/efeitos dos fármacos , Gengiva/patologia , Retração Gengival/cirurgia , Humanos , Peróxido de Hidrogênio/administração & dosagem , Hemorragia Bucal/classificação , Oxidantes/administração & dosagem , Medição da Dor/métodos , Dor Pós-Operatória/prevenção & controle , Palato/cirurgia , Hemorragia Pós-Operatória/classificação , Estudos Prospectivos , Reepitelização/efeitos dos fármacos , Cicatrização/efeitos dos fármacos
7.
Angle Orthod ; 86(3): 431-6, 2016 May.
Artigo em Inglês | MEDLINE | ID: mdl-26284755

RESUMO

OBJECTIVE: To evaluate the presence of dehiscence and fenestration defects around anterior teeth in the cleft region and to compare these findings with the noncleft side in the same patients using cone beam computed tomography (CBCT). MATERIALS AND METHODS: CBCT scans of 44 patients (26 males, 18 females; mean age, 14.04 ± 3.81 years) with unilateral cleft lip and palate (UCLP) were assessed to define dehiscences and fenestrations of the anterior teeth in both cleft and noncleft sides of the UCLP patients and a control group of noncleft patients (51 patients; 21 males, 30 females; mean age, 14.52 ± 1.16 years). Data were analyzed using Pearson's χ(2) and Student's t-test. RESULTS: The prevalence of dehiscences at the maxillary central incisors, lateral incisors, and canines teeth were 43.2%, 70.6%, and 34.1% on the cleft side and 22.7%, 53.1%, and 27.3% on the noncleft side of UCLP patients, and 13.7%, 7.8%, and 13.7% in controls, respectively (statistically no difference between the sides of cleft patients). The cleft patients had a statistically significantly higher prevalence of dehiscences than did the controls on both the cleft and noncleft sides (P < .05), except for the maxillary central incisors. Fenestrations for these teeth were significantly more common on the cleft side in UCLP patients compared with controls (P < .05), whereas the difference for maxillary lateral incisors was not statistically significant. CONCLUSIONS: Patients with UCLP showed a higher prevalence of dehiscence and fenestration defects around the maxillary anterior teeth.


Assuntos
Fenda Labial/patologia , Fissura Palatina/patologia , Tomografia Computadorizada de Feixe Cônico , Adolescente , Criança , Feminino , Humanos , Masculino , Estudos Retrospectivos
8.
Angle Orthod ; 85(6): 1003-8, 2015 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-25650761

RESUMO

OBJECTIVE: To assess the bone support of the teeth adjacent to a cleft using cone-beam computed tomography (CBCT). MATERIALS AND METHODS: The CBCT scans of 31 patients with unilateral cleft lip and palate (UCLP) were assessed. The data for teeth neighboring the cleft were compared with those of contralateral noncleft teeth. For each tooth analyzed, the distance between the cementoenamel junction (CEJ) and the bone crest (AC) at the buccal side was measured as was the thickness of the buccal bone level at 0, 1, 2, and 4 mm. RESULTS: The bone thicknesses of the central teeth at the cleft region at the crest and 2 mm apically were statistically significantly thinner than that of the central incisor at a noncleft region. The CEJ-AC distance for central teeth at the cleft region was higher than that for central teeth in a noncleft region. CONCLUSIONS: Subjects with UCLP showed reduced bone support at teeth neighboring the cleft compared with controls. This may cause some problems during orthodontic treatment.


Assuntos
Fenda Labial/patologia , Fissura Palatina/patologia , Tomografia Computadorizada de Feixe Cônico , Adolescente , Osso e Ossos , Criança , Fenda Labial/complicações , Fenda Labial/diagnóstico por imagem , Fissura Palatina/complicações , Fissura Palatina/diagnóstico por imagem , Feminino , Humanos , Masculino , Estudos Retrospectivos , Colo do Dente/patologia
9.
Lasers Med Sci ; 30(1): 11-5, 2015 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-23649613

RESUMO

Both mechanical and chemical methods can be used to clean and decontaminate implant surfaces. Incomplete debridement of infected tissue and failure to clear endotoxins can result in graft failure and a return of the defect. Recently, lasers have gained popularity for sterilizing and cleaning implant surfaces. We determined the effects of laser treatment on the surface characteristics of titanium discs with a Laser-Lok surface. The discs were irradiated with an erbium, chromium: yttrium, scandium, gallium, garnet (Er,Cr:YSGG) laser under various conditions (R1-9). Scanning electron microscopy was used to evaluate the surface. Considerable surface alterations such as melting and flattening were seen at R6 (2 W, 20 Hz, 4 mm, 45 s) and R8 (3 W, 25 Hz, 2 mm, 45 s). In addition, cracking was seen at R8. The laser parameters should be optimized to conserve surface characteristics during the irradiation of implant surfaces.


Assuntos
Cromo/química , Érbio/química , Lasers de Estado Sólido , Titânio/química , Titânio/efeitos da radiação , Microscopia Eletrônica de Varredura , Propriedades de Superfície
10.
Oral Health Prev Dent ; 13(3): 275-80, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25197730

RESUMO

PURPOSE: To investigate the periodontal examination profiles and treatment approaches of a group of Turkish general dentists. MATERIALS AND METHODS: 457 general dentists were called and 173 dentists agreed to participate in the study. The questionnaire comprised 10 questions including gender, years of experience, periodontal probing during examination, oral hygiene motivation methods (do you perform, yes/no; the oral hygiene motivation method; verbal expression or using visual materials), periodontal treatments (supragingival scaling, subgingival scaling and planing or surgery) and knowledge about diagnosis and treatment for aggressive and chronic periodontitis. The participants were grouped according to their years of clinical experience: group 1: 0 to 10 years of clinical practice (n = 58); group 2: 10 to 20 years (n = 68); group 3: >20 years (n = 47). RESULTS: The 'periodontal probing' performance percentages were 70.69%, 26.47% and 40.43% in groups 1, 2 and 3, respectively. The oral hygiene motivation rate was high in the first 10 years of clinical practice (60.3%). In addition, 72.4% of the dentists in group 1 used visual materials in addition to verbal expression during oral hygiene motivation. 72.25% of the general dentists performed supragingival scaling. The knowledge of diagnosis and treatment of chronic periodontitis was present in >90% of the dentists surveyed. In contrast, >50% of the general dentists were not knowledgeable in the diagnosis and treatment of aggressive periodontitis. CONCLUSION: Periodontal probing is a gold standard for periodontal diagnosis, but as the dentists' clinical experience increases, the frequency of its performance decreases. The percentage of the knowledge and treatment of chronic periodontitis is higher than that of aggressive periodontitis. Postgraduate education in periodontology is important to keep general dentists up to date on current periodontal practice and improve awareness of periodontal diseases.


Assuntos
Atitude do Pessoal de Saúde , Odontólogos/psicologia , Doenças Periodontais/diagnóstico , Doenças Periodontais/terapia , Padrões de Prática Odontológica , Periodontite Agressiva/diagnóstico , Periodontite Agressiva/terapia , Recursos Audiovisuais , Periodontite Crônica/diagnóstico , Periodontite Crônica/terapia , Raspagem Dentária/métodos , Feminino , Odontologia Geral/educação , Humanos , Masculino , Motivação , Higiene Bucal/educação , Educação de Pacientes como Assunto , Periodontia/educação , Aplainamento Radicular/métodos , Curetagem Subgengival/métodos , Inquéritos e Questionários , Ensino/métodos , Fatores de Tempo , Turquia
11.
Rheumatol Int ; 34(11): 1563-9, 2014 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-24715239

RESUMO

Most patients with osteoporosis are postmenopausal women or senile people who are deemed to have primary osteoporosis. However, young women, males, and atypical cases need further work up to evaluate the risk factors for secondary osteoporosis. A growing body of literature has accumulated regarding the role of osteoporosis in the onset and progression of periodontal disease and tooth loss. We hypothesized that secondary/idiopathic osteoporosis in young patients will be associated with worse periodontal status. Patients and controls who were seen in the general internal medicine outpatient clinic and who were less than 47 years of age were recruited between December 2005 and June 2011. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry. Blood samples were obtained for bone turnover markers and secondary causes of low BMD. Periodontal variables were assessed. Forty-five women whose mean age was 33.9 ± 7.7 years were enrolled. The osteoporotic group consisted of 12 patients, the osteopenic group 17 patients, and the control group 16 subjects. Significantly higher gingival recession (GR), gingival bleeding time index, and hence gingival inflammation were noted in patients with secondary osteoporosis compared to healthy subjects. In logistic regression analysis, having osteoporosis was determined as the single risk factor for increased bleeding time (b = 0.871, p = 0.008), while having osteoporosis (b = 0.181, p = 0.001) and age (b = 0.010, p < 0.001) were significant parameters with regard to GR. In conclusion, low BMD in young individuals was associated with greater gingival inflammation and recession when compared to those individuals with normal BMD values.


Assuntos
Densidade Óssea , Doenças Ósseas Metabólicas/complicações , Retração Gengival/etiologia , Gengivite/etiologia , Osteoporose/complicações , Absorciometria de Fóton , Adolescente , Adulto , Fatores Etários , Doenças Ósseas Metabólicas/diagnóstico , Doenças Ósseas Metabólicas/fisiopatologia , Estudos de Casos e Controles , Distribuição de Qui-Quadrado , Feminino , Retração Gengival/diagnóstico , Retração Gengival/fisiopatologia , Gengivite/diagnóstico , Gengivite/fisiopatologia , Humanos , Modelos Lineares , Modelos Logísticos , Pessoa de Meia-Idade , Osteoporose/diagnóstico , Osteoporose/fisiopatologia , Valor Preditivo dos Testes , Fatores de Risco , Adulto Jovem
12.
J Periodontol ; 85(3): e47-56, 2014 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-24144270

RESUMO

BACKGROUND: Volumetric alterations in gingival crevicular fluid (GCF) are widely accepted to be associated with periodontal health/disease. The volume/flow of GCF was shown to be affected by an array of methodological factors. However, relatively limited information is available on whether GCF is subject to circadian rhythm. The main aim of the present study is to assess the possible presence/absence of GCF circadian rhythm. The impact of the sampling technique on daytime volumetric variations is also analyzed. METHODS: The possible daily volumetric variations of GCF with 2-hour intervals (from 08:00 to 18:00 hours) were assessed in 100 tooth sites and 600 GCF samples. Only maxillary incisors were included to eliminate any potential volumetric differences due to tooth dimensions. To analyze the potential impact of sampling technique on GCF volume and daytime variations, at one site modified intracrevicular sampling technique (MIST) was used, whereas the contralateral site was sampled with a deep intracrevicular sampling technique (DIST). Clinical periodontal parameters of the GCF sites were also recorded. RESULTS: No significant daily variations in GCF volume could be detected. Higher volumetric measures were observed in inflamed subgroups compared with healthy subgroups (P <0.05). MIST was equivalent to DIST with regard to mean GCF volumes and the possible daytime volumetric alterations. CONCLUSIONS: Within the limits of the present study, it can be suggested that daytime variations did not have significant impact on GCF volume. The sampling methodology had no apparent impact on the circadian periodicity of GCF.


Assuntos
Ritmo Circadiano/fisiologia , Líquido do Sulco Gengival/metabolismo , Adulto , Feminino , Gengivite/classificação , Gengivite/metabolismo , Humanos , Incisivo , Masculino , Maxila , Pessoa de Meia-Idade , Índice Periodontal , Bolsa Periodontal/classificação , Bolsa Periodontal/metabolismo , Manejo de Espécimes/métodos , Fatores de Tempo , Adulto Jovem
13.
Lasers Med Sci ; 29(3): 875-80, 2014 May.
Artigo em Inglês | MEDLINE | ID: mdl-23474782

RESUMO

Lasers are used to modify the surfaces of dental implants or to decontaminate exposed implant surfaces. However, research is lacking on whether the laser causes any change on the surfaces of titanium implants. We aimed to determine the effects of laser treatment on the surface characteristics of titanium discs. Nine discs were fabricated using grade-V titanium with resorbable blast texturing surface characteristics. The discs were irradiated with an erbium, chromium: yttrium, scandium, gallium, garnet (Er,Cr:YSGG) laser under different experimental conditions (R1-9). Scanning electron microscopy was used to evaluate implant surface topography qualitatively, and a mechanical contact profilometer was used to evaluate surface roughness. The R3 and R5 parameters caused no measurable change. Minor cracks and grooves were observed in discs treated with the R1, R2, R4, R7 and R9 parameters. Major changes, such as melting, flattening and deep crack formation, were observed in discs subjected to R6 (2 W, 30 Hz, 2 mm. distance, 30 s) and R8 (3 W, 25 Hz, 2 mm. distance, 45 s) parameters. The lowest surface roughness value was obtained with the R8 parameter. Irradiation distance, duration, frequency and power were the most significant factors affecting surface roughness. Parameters such as wavelength, output power, energy, dose and duration should be considered during irradiation. The results of this study indicate that the distance between the laser tip and the irradiated surface should also be considered.


Assuntos
Lasers de Estado Sólido , Titânio/química , Implantes Dentários , Humanos , Microscopia Eletrônica de Varredura , Propriedades de Superfície
14.
Acta Odontol Scand ; 71(3-4): 553-9, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23638858

RESUMO

BACKGROUND: Pre-term birth and/or low birth weight (PTLBW) is a serious problem in developing countries. The absence of known risk factors in ≈ 50% of PTLBW cases has resulted in a continued search for other causes. The aim of this study was to examine the effect of periodontitis on pregnancy outcomes. METHODS: Samples were taken from 50 pregnant women who underwent amniocentesis. Polymerase chain reaction was performed on amniotic fluid samples obtained during amniocentesis and on subgingival plaque samples to determine the presence of Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Treponema denticola, Tannerella forsythia, Fusobacterium nucleatum, Prevotella intermedia, Campylobacter rectus and Eikenella corrodens. Plaque index, gingival index, bleeding on probing, probing depth and clinical attachment level were evaluated. Medical records were obtained after birth. RESULTS: Social and demographic variables were similar among the Gingivitis (G), Localized Periodontitis (LP) and Generalized Periodontitis (GP) groups. Four subjects gave birth to PTLBW neonates. Campylobacter rectus, T. forsythia, P. gingivalis and F. nucleatum were detected in the amniotic fluid and subgingival plaque samples of three patients who gave birth to PTLBW neonates. The amniotic fluid sample from the fourth patient was not positive for any of the tested pathogens. CONCLUSION: These findings suggest that the transmission of some periodontal pathogens from the oral cavity of the mother may cause adverse pregnancy outcomes. The results contribute to an understanding of the association between periodontal disease and PTLBW, but further studies are required to better clarify the possible relationship.


Assuntos
Líquido Amniótico/microbiologia , Recém-Nascido de Baixo Peso , Doenças Periodontais/fisiopatologia , Complicações na Gravidez/fisiopatologia , Nascimento Prematuro , Bactérias/classificação , Bactérias/genética , Bactérias/isolamento & purificação , Sequência de Bases , Primers do DNA , Feminino , Humanos , Recém-Nascido , Doenças Periodontais/complicações , Doenças Periodontais/microbiologia , Reação em Cadeia da Polimerase , Gravidez , Complicações na Gravidez/microbiologia
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