Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 27
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Arab J Gastroenterol ; 2019 Nov 21.
Artigo em Inglês | MEDLINE | ID: mdl-31759875

RESUMO

This article has been withdrawn at the request of the editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.

3.
J Clin Gastroenterol ; 53(10): 744-749, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30222644

RESUMO

PURPOSE: Initiatives by the Centers for Disease Control and Prevention as well as the National Colorectal Cancer Roundtable aim to increase the rate of colorectal cancer (CRC) screening. We assess individual and geographic characteristics associated fecal immunochemical test (FIT) CRC screening over 3 years. METHODS: This is a retrospective study of 1500 FIT kits which were mailed or opportunistically handed to eligible participants in Brooklyn, New York from January 2014 to December 2016. Eligibility criteria included increased risk for colon cancer, uninsured or underinsured, and a minimum age of 50 years to warrant CRC screening. We looked at the association of individual demographic characteristics and FIT screening by logistic regression using SPPS version 23 software. In addition, using ArcGIS, we coded patients address and layered census tract population information to find associations. RESULTS: In total, 1367 Cancer Services Participants met our study criteria. The study sample was predominantly female (95.2%) and minority (46% African American, 24.7% Hispanic, 17.3% Caucasian, 11.4% Asian) and on average 59 years old (SD, 5.7). A large majority (73%) had household incomes below $20,000/year. Approximately half (49.9%) of all Cancer Services Participants returned their FIT kit. In participants who did not return their FIT kit, the majority were African American (41%), followed by Hispanics (26.5%), Caucasians (20.6%), and Asians (11.8%). Multivariable logistic regression showed that a screening history of prior colonoscopy or FIT, gender, ethnicity, and educational attainment were significantly associated with FIT CRC screening uptake (P<0.05). Geospatial mapping showed clusters of low screening uptake in areas of high poverty. Hot-spot analysis identified areas of significant vulnerability. CONCLUSIONS: FIT uptake remains suboptimal. Individual predictors as well as area poverty is associated with low screening uptake. Geospatial mapping is an effective tool for evaluating CRC screening uptake.

4.
J Med Biogr ; : 967772018778028, 2018 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-29998747

RESUMO

The widespread use of liver biopsies underscores its utility and significance within the field of medicine. Dr. Gerald Klatskin's pioneering work on liver biopsy techniques, as well as his study of liver histopathology, paved the way for its diagnostic and therapeutic applications around the world. His attention to detail as well as meticulous account of hilar cholangiocarcinoma has had a lasting impact on the medical community. Eponymously, the tumor was named after him-Klatskin's tumor. Klatskin was also well known and respected for his commitment and devotion to his fellows who themselves went on to hold prestigious academic positions and make significant contributions of their own. The life and work of Klatskin documents a pioneering hepatologist and devoted teacher.

5.
Cureus ; 10(4): e2529, 2018 Apr 24.
Artigo em Inglês | MEDLINE | ID: mdl-29942731

RESUMO

Gastrointestinal stromal tumors (GISTs) are rare neoplasms of the digestive tract. The clinical behavior of GISTs varies greatly, has extended follow-up, and almost all of the tumors have malignant potential. The introduction of imatinib has led to extraordinary improvements in the treatment of individuals with GISTs (as well as those with Philadelphia chromosome-positive chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL)). However, there have been notable postmarketing reports of adverse drug reactions of hepatotoxicity with the use of imatinib. By our search, among individuals taking imatinib for the treatment of GIST, only six cases of drug-induced liver injury (DILI) have been reported. Here, we present an interesting case of an elderly woman who developed DILI after taking imatinib for the treatment of GIST. As the liver function tests (LFTs) initially did not improve, it was decided to proceed with an interventional radiology (IR)-guided liver biopsy, which showed a histologic pattern of acute hepatitis, consistent with DILI. Ultimately, discontinuation of the antineoplastic agent led to recovery in the patient's clinical condition along with normalization of her LFTs over the next several weeks. Thus, it is essential that physicians remain alert for and suspect DILI for any patient being treated with imatinib who presents with a sudden elevation of LFTs. The key to making the diagnosis is stopping the offending agent and closely monitoring the liver enzymes for improvement. When discontinuation of imatinib alone does not lead to improvement in LFTs and the patient's clinical status, a detailed history should be taken and initial diagnostic testing performed to exclude other etiologies. And, if they are negative, a liver biopsy should be considered.

6.
Mol Clin Oncol ; 8(5): 671-674, 2018 May.
Artigo em Inglês | MEDLINE | ID: mdl-29725533

RESUMO

Leiomyomas are rare, benign submucosal tumors originating from smooth muscle cells. The clinical presentation is usually asymptomatic, with excellent prognosis. We herein report the case of a 68-year-old female with a solitary leiomyoma found during esophagogastroduodenoscopy for hematemesis. Histopathological examination revealed smooth muscle proliferation supported by positive staining for smooth muscle myosin heavy chain and negative staining for CD117 and S-100, consistent with the marker expression pattern of leiomyoma. We report on the clinical presentation of this case, and discuss the origin, epidemiology, treatment and management of leiomyomas.

7.
Gastroenterology Res ; 11(1): 1-4, 2018 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-29511398

RESUMO

A double or accessory common bile duct (ACBD) is a rare congenital anomaly. We report the case of a 60-year-old American Asian male, who was found to have a double or duplicated common bile duct after being admitted for evaluation of a pancreatic mass. A duplicated bile duct has the same mucosa histologically as a single bile duct. However, the opening of a duplicated bile duct lacks a sphincter allowing retrograde flow of gut contents which results in a higher probability of intraductal calculus formation. On rare occasions, it can predispose to liver abscesses, pancreatitis, pancreatic cancer, gallbladder cancer, gastric cancer, and ampullary cancer depending on the location of the opening of the ACBD. We present an integrative review of the limited cases of ACBD with correlation to the current case and discussion regarding the aspects of diagnosis and management.

10.
J Med Biogr ; 26(2): 137-141, 2018 May.
Artigo em Inglês | MEDLINE | ID: mdl-29405817

RESUMO

The widespread use of endoscopy in today's clinical arena underscores its utility and growing significance within the field of medicine. Primitive forms of endoscopy have existed for hundreds of years, but it was not until the early 19th century that Dr Philipp Bozzini invented an endoscope that would form the basis of modern endoscopy. Born into an influential Italian family, Bozzini practiced medicine in a time and place of conflict and political unrest. His passion, ingenuity, and important social connections allowed him to create and introduce to the medical profession the Lichtleiter (light-conductor), which overcame two key issues plaguing endoscopy: inadequate lighting and poor penetration. A combination of professional rivalry and his premature passing stifled enthusiasm and further work on the Lichtleiter, but its value would not be lost forever. The advancements in the field of endoscopy that have come since the time of the Lichtleiter all build upon the principles of Bozzini, who became widely acknowledged as the father of modern endoscopy.


Assuntos
Endoscópios/história , Endoscopia/história , Endoscopia/instrumentação , Alemanha , História do Século XVIII , História do Século XIX
11.
Gastroenterology Res ; 11(6): 436-440, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30627269

RESUMO

We describe a case of a 31-year-old man who presented with a 3-year history of worsening upper abdominal pain, nausea, and vomiting: symptoms that were resistant to medical treatment and unexplained despite a thorough diagnostic evaluation. Then, an upper gastrointestinal series with small bowel follow-through showed proximal duodenal dilation and distal decompression of the duodenum, suggestive of a partial duodenal obstruction. An abdominal computed tomography (CT) scan revealed a transition point in the distal duodenum. At surgery, a segmental resection of the distal duodenum with a duodenojejunal anastomosis was performed. Histopathologic examination of the specimen revealed Crohn's disease. Therefore, making the diagnosis of duodenal obstruction has significant clinical implications and, in the setting of Crohn's disease, is evidence of an underlying intestinal stricture, stenotic area, or adhesion.

12.
Gastroenterology Res ; 10(5): 322-324, 2017 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-29118876

RESUMO

Pancreatic dermoid cysts are rare and benign congenital abnormalities of germ cell origin. They occur equally in males and females without age predilection. Though radiographic imaging aids in the diagnosis, most times they are inconclusive and require fine-needle aspiration cytology for confirmation. We report the first case of a dermoid cyst presenting as recurrent pancreatitis in a 49-year-old male. Computed tomography scan, followed by magnetic resonance imaging, showed a complex cystic mass lesion adjacent to the pancreatic tail. Endoscopic ultrasound noted a large heterogeneous cystic lesion with hypoechoic wall layers in the tail of the pancreas without invading surrounding structures. Fine-needle aspiration cytology revealed numerous mature squamous cells consistent with a pancreatic dermoid cyst. We discuss the history, clinical presentation, diagnosis, and treatment of pancreatic dermoid cysts.

13.
Gastroenterology Res ; 10(2): 147-148, 2017 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-28496541

RESUMO

Gastric volvulus has been reported in all age groups; however, it is typically diagnosed in the elderly. Organo-axial volvulus is the most common type, followed by the mesentero-axial and the combined types. Depending on the etiology, gastric volvulus can also be classified as primary (idiopathic) or secondary. Treatment of acute gastric volvulus involves laparoscopic or endoscopic procedures/maneuvers, depending on the severity of symptoms and surgical eligibility of the patient. Chronic gastric volvulus is typically managed conservatively, although laparoscopic or endoscopic interventions can also be employed depending on the severity of presentation.

14.
Gastroenterology Res ; 10(1): 42-44, 2017 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-28270876

RESUMO

While an uncommon occurrence, it is possible for patients diagnosed with acute pancreatitis to develop colonic ileus, obstruction, or perforation. By extension, it is also possible to develop a small bowel obstruction following an episode of acute pancreatitis. Here, we present the case of a 44-year-old male, who after repeated attacks of acute pancreatitis, came to the emergency department with continuous, non-bloody vomiting. This patient also complained of both left upper quadrant and epigastric pain, and was subsequently diagnosed with a small bowel obstruction involving the proximal jejunum.

16.
Clin Anat ; 29(4): 516-23, 2016 May.
Artigo em Inglês | MEDLINE | ID: mdl-26579995

RESUMO

The aim of this study was to explore the anatomical variations of the nerve to the levator ani (LA) and to relate these findings to LA dysfunction. One hundred fixed human female cadavers were dissected using transabdominal, gluteal, and perineal approaches, resulting in two hundred dissections of the sacral plexus. The pudendal nerve and the sacral nerve roots were traced from their origin at the sacral foramina to their termination. All nerves contributing to the innervation of the LA were considered to be the nerve to the LA. Based on the spinal nerve components, the nerve to the LA was classified into the following categories: 50% (n = 100) originated from S4 and S5 (type I); 19% (n = 38) originated from S5 (type II); 16% (n = 32) originated from S4 (type III); 11% (n = 22) originated from S3 and S4 (type IV); 4% (n = 8) originated from S3, S4, and S5 (type V). Two patterns of nerve termination were observed. In 42% of specimens, the nerve to the LA penetrated the coccygeus muscle and assumed an external position along the inferior surface of the LA muscle. In the remaining 58% of specimens, the nerve crossed the superior surface of the coccygeus muscle and continued along the superior surface of the iliococcygeus muscle. Damage to the nerve to LA has been associated with various pathologies. In order to minimize injuries during surgical procedures, a thorough understanding of the course and variations of the nerve to the LA is extremely important.


Assuntos
Músculo Esquelético/inervação , Diafragma da Pelve/inervação , Nervo Pudendo/anatomia & histologia , Raízes Nervosas Espinhais/anatomia & histologia , Feminino , Humanos , Distúrbios do Assoalho Pélvico/patologia , Pelve , Região Sacrococcígea/inervação
17.
Clin Anat ; 28(1): 5-11, 2015 01.
Artigo em Inglês | MEDLINE | ID: mdl-24753297

RESUMO

Heinrich Obersteiner (1847-1921) was amongst the most influential neuroscientists in the 19th century. Born into a family of physicians, he gained early exposure to medicine, and as a medical student, he focused much of his research in neuroanatomy, eventually becoming a professor of neuroanatomy at the University of Vienna. Throughout his academic career, he focused greatly on neuropathology, and incorporated much of his research into his textbook, "Introduction to the Study of the Structure of the Central Nervous Organs in Health and Disease," which was considered the foremost reference text of neurology for many generations of scholars. The culmination of his contributions to the neurological world can be seen as the Neurological Institute of Vienna, which he founded in 1882. Scholars from all over the world sought out his expertize and tutelage. While he was the director of the Institute, over 500 articles were published within the Obersteiner-Arbeiten. Much of this work helped set the foundation for the eventual development of neurology as a medical discipline. A review of his life will help us better understand the legacy Heinrich Obersteiner left in the field of neurology.


Assuntos
Neuroanatomia/história , Neurologia/história , Neuropsiquiatria/história , Academias e Institutos/história , Áustria , História do Século XIX , História do Século XX , Publicações Periódicas como Assunto/história
18.
World J Gastrointest Pharmacol Ther ; 5(3): 191-5, 2014 Aug 06.
Artigo em Inglês | MEDLINE | ID: mdl-25133048

RESUMO

Statin induced pancreatitis has historically been considered a diagnosis of exclusion, with literature references typically in the form of case reports and observational studies. Recently, larger studies have challenged the correlations made by earlier case reports, and instead demonstrate a mild protective effect in statin users. We present a case report of likely statin induced pancreatitis in a 58-year-old male (which we have attributed to drug-drug interaction with resulting inhibition of hepatic cytochrome P450 enzymes) and have reviewed the apparent dichotomy in the available literature.

19.
Clin Anat ; 27(7): 958-63, 2014 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-25041967

RESUMO

Étienne-Arthur Louis Fallot (1850-1911) is one of the most significant medical figures of the 19th century with an eponymous congenital cardiac malformation. His initial account of the four anatomical features making up his tetralogy proved remarkably significant in the progression of clinical descriptions of the lesions producing cyanotic congenital cardiac disease. Although subsequently the cause of appreciable controversy, the accuracy of his initial descriptions underscore the current diagnostic and therapeutic approach to the malformation now known uniformly as tetralogy of Fallot.


Assuntos
Patologia/história , Tetralogia de Fallot/história , História do Século XIX , História do Século XX
20.
Med Sci Monit ; 20: 818-24, 2014 May 19.
Artigo em Inglês | MEDLINE | ID: mdl-24835144

RESUMO

BACKGROUND: The season of diagnosis of several forms of cancer has been observed to impact survival, supporting the hypothesis that vitamin D3 has a protective role in cancer survival. All previous studies demonstrating this seasonality were performed in European populations residing at latitudes upwards of 50°N. This study investigated whether seasonality of prognosis persists in populations residing in the lower latitudes of the contiguous United States (Latitude 21°N to 48°N). MATERIAL/METHODS: The 5-year survival data of 19 204 female breast cancer, 6740 colorectal cancer, and 1644 prostate cancer cases was analyzed. RESULTS: Female breast cancer patients exhibited improved survival when diagnosed in the summer as compared to the winter at all latitudes (Hazard Ratio [HR]: 0.940, 95%; Confidence Interval [CI]: 0.938 to 0.941, P=0.002). Colorectal cancer and prostate cancer also exhibited a similar seasonal pattern (HR: 0.978, 95% CI: 0.975 to 0.980, P=0.008 and HR: 0.935, 95%, CI 0.929 to 0.943, P=0.006), respectively, when the analysis was restricted to northern regions. CONCLUSIONS: These observations contribute to the mounting evidence that vitamin D3 may affect the progression of cancer. Data also suggest that vitamin D3 status at the onset of treatment may synergistically improve the prognosis of several cancer types.


Assuntos
Neoplasias da Mama/epidemiologia , Neoplasias Colorretais/epidemiologia , Geografia , Neoplasias da Próstata/epidemiologia , Estações do Ano , Neoplasias da Mama/diagnóstico , Neoplasias Colorretais/diagnóstico , Feminino , Humanos , Modelos Lineares , Masculino , Modelos de Riscos Proporcionais , Neoplasias da Próstata/diagnóstico , Programa de SEER , Estados Unidos/epidemiologia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA