Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 57
Filtrar
1.
Front Neurol ; 12: 704109, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34552551

RESUMO

Background: The behavioral variant of frontotemporal dementia (bvFTD), characterized by early behavioral abnormalities and late memory impairment, is a neurodegenerative disorder with a detrimental impact on patients and their caregivers. bvFTD is often difficult to distinguish from other neurodegenerative diseases, such as Alzheimer's disease (AD), using brief cognitive tests. Combining brief socio-cognitive and behavioral evaluations with standard cognitive testing could better discriminate bvFTD from AD patients. We sought to evaluate the diagnostic accuracy of brief socio-cognitive tests that may differentiate bvFTD and AD patients with low educational levels. Methods: A prospective study was performed on 51 individuals over the age of 50 with low educational levels, with bvFTD or AD diagnosed using published criteria, and who were receiving neurological care at a multidisciplinary neurology clinic in Lima, Peru, between July 2017 and December 2020. All patients had a comprehensive neurological evaluation, including a full neurocognitive battery and brief tests of cognition (Addenbrooke's Cognitive Examination version III, ACE-III), social cognition (Mini-social Cognition and Emotional Assessment, Mini-SEA), and behavioral assessments (Frontal Behavioral Inventory, FBI; Interpersonal Reactivity Index-Emphatic Concern, IRI-EC; IRI-Perspective Taking, IRI-PT; and Self-Monitoring Scale-revised version, r-SMS). Receiver operating characteristic (ROC) analysis to calculate the area under the curve (AUC) was performed to compare the brief screening tests individually and combined to the gold standard of bvFTD and AD diagnoses. Results: The AD group was significantly older than the bvFTD group (p < 0.001). An analysis of the discriminatory ability of the ACE-III to distinguish between patients with AD and bvFTD (AUC = 0.85) and the INECO Frontal Screening (IFS; AUC = 0.78) shows that the former has greater discriminatory ability. Social and behavioral cognition tasks were able to appropriately discriminate bvFTD from AD. The Mini-SEA had high sensitivity and high moderate specificity (83%) for discriminating bvFTD from AD, which increased when combined with the brief screening tests ACE-III and IFS. The FBI was ideal with high sensitivity (83%), as well as the IRI-EC and IRI-PT that also were adequate for distinguishing bvFTD from AD. Conclusions: Our study supports the integration of socio-behavioral measures to the standard global cognitive and social cognition measures utilized for screening for bvFTD in a population with low levels of education.

2.
Am J Alzheimers Dis Other Demen ; 36: 15333175211039089, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34416114

RESUMO

To evaluate neuropsychiatric symptoms in patients with Alzheimer's disease (AD) and their association with cognition and functionality during lockdown of the COVID-19's first wave. We included 91 patients and caregivers of people with AD from a memory clinic. The RUDAS, M@T, and CDR were administered to patients and NPI/ADCS-ADL to caregivers. Baseline and lockdown measurements scales were analyzed to compare the frequencies at baseline versus lockdown and conditional Odds Ratio (ORc) was calculated for the neuropsychiatric symptoms. During the pandemic, significant increase in the number of cases was observed in depression (23%), agitation (36.8%), aberrant motor activity (12%), sleep disorders (26.3%), and appetite change (12.1%). In worsening of pre-existing symptoms, the most frequent were delusions (75%), followed by sleep disorders (71.7%). Lockdown induces a rapid increase of neuropsychiatric symptoms affecting cognitive symptoms and functionality of Peruvian patients with AD.


Assuntos
Doença de Alzheimer , COVID-19 , Doença de Alzheimer/epidemiologia , Controle de Doenças Transmissíveis , Humanos , Testes Neuropsicológicos , Pandemias , Peru/epidemiologia , SARS-CoV-2
3.
J Med Virol ; 2021 Aug 26.
Artigo em Inglês | MEDLINE | ID: mdl-34436792

RESUMO

Dengue virus and severe acute respiratory syndrome coronavirus 2 coexist in dengue-endemic countries; therefore, the adoption of preventive measures is essential to control the spread of both viruses. We conducted an ecological study to compare the temporal patterns of the incidence of dengue before and during the Coronavirus disease 2019 (COVID-19) pandemic in Peru. A time-series analysis comparing the incidence of dengue using a Student's t test with variance correction was performed. Poisson regression was applied to determine the incidence rate ratio (IRR) of dengue before and during the COVID-19 pandemic. The incidence of dengue was found to be increased in all endemic regions of Peru during the COVID-19 pandemic, with the highest incidences registered in Ica (IRR = 90.14), Huánuco (IRR = 38.6), and Ucayali (IRR = 23.78), with the exception of Piura (IRR = 0.83). The highest increases in the number of dengue cases per million inhabitants were in Ucayali (393.38), Tumbes (233.19), Ica (166.08), and Loreto (129.93). The gradient of dengue cases was positive in all endemic regions during the COVID-19 pandemic. The number of dengue cases per million increased during the COVID-19 pandemic throughout Peru and in several endemic regions, with the exception of Piura.

4.
Colomb Med (Cali) ; 52(1): e7014577, 2021 Mar 18.
Artigo em Inglês | MEDLINE | ID: mdl-33911322

RESUMO

Case description: 32-month-old boy, IgG positive for SARS-CoV-2, presented to the emergency department with dermatologic lesions. Clinical findings: Four days before admission, he presented skin eruptions with redness and pruritus on hands and feet. Generalized papular erythema was evidenced, upper extremities with diffuse erythematosquamous plaques, palmoplantar keratoderma, so he was evaluated by a dermatologist who diagnosed pityriasis rubra pilaris. Treatment and outcome: rehydrating cream, cetirizine 0.5 mg/kg/day every two days, and prednisolone 2 mg/kg/day in the morning. He was discharged after 14 days, the patient presented clinical improvement, but the erythematous lesion persisted on the trunk and extremities. In the evaluation, after three months, the patient did not show the described lesions, evidencing an improvement and clinical resolution of the dermatological problems. Clinical relevance: We report a patient with pityriasis rubra piloris associated with a post-infection by SARS-CoV-2 that had not been described before.


Assuntos
COVID-19/complicações , Pitiríase Rubra Pilar/etiologia , Cetirizina/administração & dosagem , Pré-Escolar , Glucocorticoides/administração & dosagem , Humanos , Imunoglobulina G , Masculino , Pitiríase Rubra Pilar/diagnóstico , Pitiríase Rubra Pilar/tratamento farmacológico , Prednisolona/administração & dosagem
5.
PeerJ ; 9: e11210, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33868828

RESUMO

Background: Estimating the cumulative prevalence of SARS-COV-2 will help to understand the epidemic, contagion, and immunity to COVID-19 in vulnerable populations. The objective is to determine the extent of infection in the general population and the cumulative incidence by age group. Methods: It was carried out with a longitudinal analytical study, in the population of the Lambayeque region, located in the north of Peru. The selection was carried out in multistages (districts, area, household, and finally choosing the interviewee within the house). Seroprevalence was estimated as a positive result of the rapid test whether it was positive IgM or positive IgG. An adjustment was made for the sampling weights used. Results: The seroprevalence found in the region was 29.5%. Young people between 21 and 50 years old presented the highest seroprevalence frequencies. A total of 25.4% were asymptomatic. The most frequent complaint was dysgeusia and dysosmia (85.3% and 83.6%). Dysosmia (PR = 1.69), chest pain (PR = 1.49), back pain (PR = 1.45), cough (PR = 1.44), fever (PR = 1.41), general malaise (PR = 1.27) were associated factors with the higher the frequency of seropositivity for SARS-CoV-2. Reporting of complete isolation at home decreased the frequency of positivity (PR = 0.80), however, reporting having ARI contact (PR = 1.60), having contact with a confirmed case (PR = 1.51), and going to market (PR = 1.26) increased the frequency of positivity for SARS-CoV-2. Conclusion: These results suggest that Lambayeque is the region with the highest seroprevalence in the world, well above Spain, the United States and similar to a study in India.

6.
Acta méd. peru ; 38(2): 145-150, abr.-jun 2021. tab
Artigo em Espanhol | LILACS-Express | LILACS | ID: biblio-1339026

RESUMO

RESUMEN El cáncer pulmonar es un problema de salud pública debido a su alta morbimortalidad mundial y en el Perú. En el cáncer pulmonar de células no pequeñas (CPCNP) la detección de mutaciones del receptor del factor de crecimiento epidérmico (EGFR) ha sido útil para elección de la terapéutica de esta enfermedad. El presente artículo tiene como objetivo discutir la información actual y relevante sobre la biopsia liquida como técnica diagnóstica en detección de mutaciones del gen EGFR en pacientes con cáncer pulmonar de células no pequeñas. Las principales guías de cáncer y dos revisiones sistemáticas muestran evidencia a favor de la biopsia líquida en busca de mutaciones del gen EGFR, esto como una alternativa a la biopsia de tejido al inicio de diagnóstico y con una mayor aceptación de uso en el escenario clínico de pacientes con CPCNP con mutaciones sensibles de EGFR. Esta tecnología sanitaria puede ser útil en nuestro país, y proponemos su uso en dos escenarios clínicos.


ABSTRACT Lung cancer is a public health problem due to its high morbidity and mortality worldwide and in Peru. In non-small cell lung cancer, the detection of mutations of the epidermal growth factor receptor (EGFR) has been useful for the choice of therapeutics for this disease. In the present article we aim to discuss current and relevant information on the best diagnostic technique for EGFR in patients with non-small cell lung cancer. The main cancer guidelines and two systematic reviews showed evidence in favor of the diagnosis of EGFR gene mutations on liquid biopsy as an alternative to tissue biopsy at the beginning of diagnosis and with a greater acceptance use, in the clinical setting of NSCLC patients with sensitive EGFR mutations. This healthcare technology may be useful in our country, and we propose its use in two clinical scenarios.

7.
PLoS Negl Trop Dis ; 15(3): e0009144, 2021 03.
Artigo em Inglês | MEDLINE | ID: mdl-33730099

RESUMO

BACKGROUND: Oral ivermectin is a safe broad spectrum anthelminthic used for treating several neglected tropical diseases (NTDs). Currently, ivermectin use is contraindicated in children weighing less than 15 kg, restricting access to this drug for the treatment of NTDs. Here we provide an updated systematic review of the literature and we conducted an individual-level patient data (IPD) meta-analysis describing the safety of ivermectin in children weighing less than 15 kg. METHODOLOGY/PRINCIPAL FINDINGS: A systematic review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) for IPD guidelines by searching MEDLINE via PubMed, Web of Science, Ovid Embase, LILACS, Cochrane Database of Systematic Reviews, TOXLINE for all clinical trials, case series, case reports, and database entries for reports on the use of ivermectin in children weighing less than 15 kg that were published between 1 January 1980 to 25 October 2019. The protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO): CRD42017056515. A total of 3,730 publications were identified, 97 were selected for potential inclusion, but only 17 sources describing 15 studies met the minimum criteria which consisted of known weights of children less than 15 kg linked to possible adverse events, and provided comprehensive IPD. A total of 1,088 children weighing less than 15 kg were administered oral ivermectin for one of the following indications: scabies, mass drug administration for scabies control, crusted scabies, cutaneous larva migrans, myiasis, pthiriasis, strongyloidiasis, trichuriasis, and parasitic disease of unknown origin. Overall a total of 1.4% (15/1,088) of children experienced 18 adverse events all of which were mild and self-limiting. No serious adverse events were reported. CONCLUSIONS/SIGNIFICANCE: Existing limited data suggest that oral ivermectin in children weighing less than 15 kilograms is safe. Data from well-designed clinical trials are needed to provide further assurance.


Assuntos
Anti-Helmínticos/efeitos adversos , Helmintíase/tratamento farmacológico , Ivermectina/efeitos adversos , Administração Oral , Anti-Helmínticos/administração & dosagem , Peso Corporal , Pré-Escolar , Humanos , Lactente , Ivermectina/administração & dosagem , Doenças Negligenciadas/tratamento farmacológico
8.
Colomb. med ; 52(1): e7014577, Jan.-Mar. 2021. graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1249641

RESUMO

Abstract Case description: 32-month-old boy, IgG positive for SARS-CoV-2, presented to the emergency department with dermatologic lesions. Clinical findings: Four days before admission, he presented skin eruptions with redness and pruritus on hands and feet. Generalized papular erythema was evidenced, upper extremities with diffuse erythematosquamous plaques, palmoplantar keratoderma, so he was evaluated by a dermatologist who diagnosed pityriasis rubra pilaris. Treatment and outcome: rehydrating cream, cetirizine 0.5 mg/kg/day every two days, and prednisolone 2 mg/kg/day in the morning. He was discharged after 14 days, the patient presented clinical improvement, but the erythematous lesion persisted on the trunk and extremities. In the evaluation, after three months, the patient did not show the described lesions, evidencing an improvement and clinical resolution of the dermatological problems. Clinical relevance: We report a patient with pityriasis rubra piloris associated with a post-infection by SARS-CoV-2 that had not been described before.


Resumen Descripción del caso: Niño 32 meses de vida, con IgG positivo para SARS-CoV-2, acude al servicio de emergencia por presentar lesiones dermatológicas. Hallazgos clínicos: Cuatro días antes del ingreso presentó erupciones en la piel, con enrojecimiento y prurito en manos y pies. Se evidenció eritema papular generalizado, extremidades superiores con placas eritematoescamosas difusas, queratodermia palmo-plantar por lo que es evaluado por dermatólogo quien diagnostica pitiriasis rubra pilaris. Tratamiento y resultado: Crema rehidratantes, cetirizina 0.5 mg/kg/día cada 2 días y prednisolona 2 mg/kg/día por la mañana. Fue dado de alta a los 14 días, el paciente presenta mejora clínica, pero aún persiste la lesión eritematosa en tronco y extremidades. En la evaluación a los tres meses el paciente no mostró las lesiones descritas, evidenciando una mejoría y resolución clínica de los problemas dermatológicos. Relevancia clínica: Se reporta un paciente con afectación por pitiriasis rubra piloris asociado a una post-infección por SARS-CoV-2 que no se había descrito antes.

10.
Electrophoresis ; 42(3): 200-205, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-33128395

RESUMO

Although knowledge on glycan biosynthesis and processing is continuously maturing, there are still a limited number of studies that examine biological functions of N-glycan structures in plants, which remain virtually unknown. Here, the statistical correlation between nutrient (nitrogen) deficiency symptoms of crops and changes in 8-aminopyrene-1,3,6-trisulfonic acid (APTS)-labeled complex type free oligosaccharides is reported. While deficiency symptoms are predicted by multispectral images and Kjeldahl digestion, APTS-labeled complex type free oligosaccharides are identified by their glucose unit (GU) values in tomato xylem sap, using capillary electrophoresis with laser induced fluorescence detection (CE-LIF). Given the limited number of structures obtained from plants, archived in the literature, in the future, it is intended to create an open access database of promising indicators, namely, glycan structures that are presumably responsible for the nutrient deficiency caused stress in plants (http://glycoplants.org).

11.
Acta méd. peru ; 37(4): 518-531, oct-dic 2020. tab, graf
Artigo em Espanhol | LILACS-Express | LILACS | ID: biblio-1278176

RESUMO

RESUMEN El presente artículo resume la guía de práctica clínica (GPC) para tamizaje, diagnóstico y manejo de los pacientes con enfermedad renal crónica (ERC) en los estadios 1 al 3 en el Seguro Social del Perú (EsSalud). Para el desarrollo de esta GPC, se conformó un grupo elaborador de la guía (GEG) que incluyó especialistas clínicos y metodólogos, el cual formuló ocho preguntas clínicas. Para responder cada pregunta se realizaron búsquedas sistemáticas de revisiones sistemáticas y, cuando fue considerado pertinente, de estudios primarios; y se seleccionó la evidencia pertinente. La certeza de la evidencia fue evaluada usando la metodología Grading of Recommendations Assessment, Development, and Evaluation (GRADE). En reuniones periódicas, el GEG usó la metodología GRADE para revisar la evidencia y emitir las recomendaciones. Se emitieron ocho recomendaciones (cuatro fuertes y cuatro condicionales), 29 puntos de buena práctica clínica, y tres flujogramas.


ABSTRACT This paper summarizes the clinical practice guidelines (CPG) for the screening, diagnosis, and management of patients with chronic kidney disease (CKD) stages 1-3 in the Social Security of Peru (EsSalud). A guideline development group (GDG) was established for develop this CPG, which included clinical and methodology specialists, who formulated 08 clinical questions. Systematic searches of systematic reviews and, when considered necessary, primary studies were conducted to answer each question; and relevant evidence was selected. The certainty of the evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology. In periodic work meetings, the GDG used the GRADE methodology for reviewing the evidence and for developing recommendations. At the end, this CPG formulated 08 recommendations (04 strong and 04 conditional), 29 points of good clinical practice, and 03 flowcharts were formulated.

12.
Rev. Asoc. Esp. Espec. Med. Trab ; 29(3): 236-244, sept. 2020. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-200268

RESUMO

OBJETIVO: Determinar los factores sociolaborales asociados a la variación del IMC y circunferencia de cintura en trabajadores de 15 ciudades peruanas. Material y MÉTODO: Se realizó un análisis secundario de datos, en donde se asoció el IMC y la circunferencia de cintura al periodo laboral (menor de 1 año, hasta 5 años, hasta 10 años, hasta 20 años y más de 20 años), el sexo, la edad y el tipo de trabajador. RESULTADOS: Según el análisis multivariado, el IMC estuvo asociado al sexo masculino (valor p < 0,001) y con el incremento de edad (valor p < 0,001). En cambio, el diámetro de cintura se asoció de forma positiva con tener periodos laborales de hasta 5 años (valor p: 0,015), de hasta 10 años (valor p < 0,001) y de hasta 20 años (valor p: 0,003), así como, con el incremento de la edad (valor p < 0,001). CONCLUSIÓN: Se encontró que el sexo y la edad se relacionaban a la variación del IMC, en cambio, el periodo laboral y la edad estuvieron asociados al diámetro de cintura


OBJECTIVE: To determine the socio-labour factors associated with variation in BMI and waist circumference in workers in 15 Peruvian cities. Material and METHOD: A secondary data analysis was performed, in which BMI and waist circumference were associated to the work period (less than 1 year, up to 5 years, up to 10 years, up to 20 years and more than 20 years), sex, age and type of worker. RESULTS: According to the multivariate analysis, BMI was associated with male sex (p < 0.001 value) and with increasing age (p < 0.001 value). On the other hand, waist circumference was positively associated with working periods of up to 5 years (p-value: 0.015), up to 10 years (p-value < 0.001) and up to 20 years (p-value: 0.003), as well as with increasing age (p-value < 0.001). CONCLUSION: It was found that sex and age were related to BMI variation, whereas work period and age were associated to waist diameter


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Índice de Massa Corporal , Razão Cintura-Estatura , Saúde do Trabalhador , Fatores Socioeconômicos , Fatores de Tempo , Peru
13.
Glob Health Promot ; 27(4): 123-130, 2020 12.
Artigo em Inglês | MEDLINE | ID: mdl-32829693

RESUMO

INTRODUCTION: Approximately three billion people in Asia, Africa, and the Americas cook with biomass, cleaner cooking technologies with the potential to reduce household air pollution exposure. It is necessary to assess the adoption and long-term use of these stoves, measure perceived benefits among users, and use this information to provide feedback to programs that are implementing new cooking technologies. The aim of this study is to determine the level of adoption and impact of improved biomass cookstoves in the rural area of Lambayeque, Peru, in 2017. METHODS: A descriptive cross-sectional study was conducted. A total of 52 homes were surveyed in the districts of Pacora and Íllimo where improved biomass stoves were introduced between 2005 and 2013. A questionnaire for the assessment of adoption and impact indexes proposed by the Global Alliance for Clean Cookstoves was applied. The STROBE checklist was used. RESULTS: The mean number of years with the improved biomass cookstove was 9.1 (standard deviation: 2.9); 51.9% always used the improved stove, and 34.6% never used it due to destruction during the El Niño phenomenon in 2017. The median impact index was 5.62; 19.2% had a very good/good adoption. The median adoption index was 6.5; 25% had a very high/high impact. The use of the traditional or open fire biomass stove persisted in 61.5% of the houses. CONCLUSION: The adoption and impact of improved biomass cookstoves were acceptable, but traditional stove use persisted in more than half of the houses. Households used a mix of different stove technologies. Gas stoves were used more frequently for breakfast or dinner, while the traditional biomass stoves were used for larger lunchtime meals.

14.
Medwave ; 20(6): e7972, 2020 Jul 23.
Artigo em Espanhol, Inglês | MEDLINE | ID: mdl-32759895

RESUMO

Introduction: Chronic gastritis is one of the most common diseases in the population. Several factors influence its appearance; however, the effect of high altitude has not been studied thoroughly. Objective: To determine the association between the altitude of the residential area and chronic gastritis in outpatients of Peru. Methods: Observational, analytical, and cross-sectional study. Secondary data analysis was conducted. The dependent variable was chronic gastritis, obtained from patient references, and verified in the medical history according to the pathological history mentioned during medical consultation. The independent variable was the altitude of the residential areas (categorized into low altitude, intermediate altitude, high and very high), and the secondary co-variables were age, sex, and time living at altitude. Generalized linear models were used to estimate prevalence ratios using Poisson family and city as a cluster. Results: Of the 4263 patients studied, 63% were female; the median age was 42 years. The overall prevalence of chronic gastritis was 12,9%. There was an association with chronic gastritis and altitude of residence at the intermediate and high levels, but not at the very high; with an adjusted prevalence ratio of 1.52 (95% confidence interval, 1.03 to 2.23); 2.01 (1.55 to 2.60) and 1.12 (0.84 to 1.48), respectively. Conclusions: We found a significant association between chronic gastritis and intermediate and high altitude but not at very high, which could be explained by hypobaric hypoxia in altitude that could lead to gastric wall lesions and other socio-demographic variables.


Assuntos
Altitude , Gastrite/epidemiologia , Adulto , Doença Crônica , Estudos Transversais , Feminino , Gastrite/diagnóstico , Humanos , Masculino , Peru/epidemiologia , Prevalência
15.
Respir Med Case Rep ; 31: 101142, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32670788

RESUMO

Infections with protozoans, mainly due to immunodeficiency, are common all over the world. However, pulmonary infections with protozoans are less frequent. Lophomonas sp. is a flagellated protozoan that lives in the gastrointestinal tract of some species of cockroaches. Some cases, that show the presence of Lophomonas in populations whose lungs are affected, have been reported. Case report: The medical records of nine patients were studied: seven adult patients and two pediatric patients who were in the Intensive Care Unit (ICU) and in the Neonatal Intensive Care Unit (NICU), respectively. The samples were taken from tracheal aspirations and bronchoalveolar lavages. The patients' ages were between 9 and 95 years, and 60% of them were male. Some of the patients were healthy, a priori, and others were immunosuppressed. There were found three patients with neoplasia, two patients with diabetes mellitus and four patients with no systemic pathologies. It is concluded that Lophomonas sp. is a protozoa parasite which emerges from the upper and lower respiratory tract of hospitalized patients. However, its pathogenic role is still controversial in all cases, that's why it merits further study for its understanding and possible treatment.

16.
Medwave ; 20(6): e7972, 31-07-2020.
Artigo em Inglês, Espanhol | LILACS | ID: biblio-1118990

RESUMO

INTRODUCCIÓN: La gastritis crónica es unas de las enfermedades más comunes en la población y varía por regiones. Existen diversos factores que influyen en su aparición. Sin embargo, no se ha estudiado a profundidad el efecto de la altura. OBJETIVOS: Determinar la asociación entre la zona altitudinal de residencia y gastritis crónica en pacientes ambulatorios de Perú. MÉTODOS: Estudio transversal analítico. Se realizó a través del análisis secundario de datos. La variable dependiente fue gastritis crónica, tomada del reporte del paciente y verificado en la historia clínica, según antecedentes patológicos mencionados durante consulta médica. La variable independiente fue la zona altitudinal de residencia (divida en baja altitud, altitud intermedia, elevada y muy elevada). Las covariables secundarias fueron edad, sexo y tiempo viviendo en altura. Se realizaron modelos lineales generalizados para estimar razones de prevalencias, usando familia Poisson y ciudad como clúster. RESULTADOS: De los 4263 pacientes estudiados, 63% fue del sexo femenino; la mediana de la edad fue de 42 años. La prevalencia global de gastritis crónica fue 12,9%. Hubo asociación con gastritis crónica y altura de residencia a nivel intermedio, elevado, pero no con muy elevado, con una razón de prevalencia ajustada de 1,52 (intervalo de confianza 95%: 1,03 a 2,23); 2,01 (1,55 a 2,60) y 1,12 (0,84 a 1,48), respectivamente. CONCLUSIONES: Se encontró una asociación significativa entre gastritis crónica y altitud intermedia y elevada, pero no en muy elevada. Esto se explicaría por la hipoxia hipobárica en alturas, que podría conllevar lesiones en la pared gástrica, la adaptación de los peruanos a las alturas y por otras variables sociodemográficas.


INTRODUCTION: Chronic gastritis is one of the most common diseases in the population. Several factors influence its appearance; however, the effect of high altitude has not been studied thoroughly. OBJECTIVE: To determine the association between the altitude of the residential area and chronic gastritis in outpatients of Peru. METHODS: Observational, analytical, and cross-sectional study. Secondary data analysis was conducted. The dependent variable was chronic gastritis, obtained from patient references, and verified in the medical history according to the pathological history mentioned during medical consultation. The independent variable was the altitude of the residential areas (categorized into low altitude, intermediate altitude, high and very high), and the secondary co-variables were age, sex, and time living at altitude. Generalized linear models were used to estimate prevalence ratios using Poisson family and city as a cluster. RESULTS: Of the 4263 patients studied, 63% were female; the median age was 42 years. The overall prevalence of chronic gastritis was 12,9%. There was an association with chronic gastritis and altitude of residence at the intermediate and high levels, but not at the very high; with an adjusted prevalence ratio of 1.52 (95% confidence interval, 1.03 to 2.23); 2.01 (1.55 to 2.60) and 1.12 (0.84 to 1.48), respectively. CONCLUSIONS: We found a significant association between chronic gastritis and intermediate and high altitude but not at very high, which could be explained by hypobaric hypoxia in altitude that could lead to gastric wall lesions and other socio-demographic variables.


Assuntos
Humanos , Masculino , Feminino , Adulto , Altitude , Gastrite/epidemiologia , Peru/epidemiologia , Doença Crônica , Prevalência , Estudos Transversais , Gastrite/diagnóstico
18.
Rev Soc Bras Med Trop ; 53: e20190164, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32187332

RESUMO

INTRODUCTION: Toxoplasmosis is a zoonosis caused by Toxoplasma gondii. This study investigated the prevalence and factors associated with toxoplasmosis among pregnant women. METHODS: We followed an analytical observational study. From July 2016 to June 2017, 218 pregnant women were selected. The infection was detected through serological dosage of anti-T.gondii Immunoglobulin(Ig) M and IgG antibodies. RESULTS: The seroprevalence was 35.8%; the factors associated with infection were consumption of non-drinking water, residence in an urban area, and threatened abortion during the current pregnancy. CONCLUSIONS: The seroprevalence of toxoplasmosis among pregnant women is high. The risk factors are dependent on environmental determinants.


Assuntos
Anticorpos Antiprotozoários/sangue , Complicações Parasitárias na Gravidez/epidemiologia , Complicações Parasitárias na Gravidez/parasitologia , Toxoplasmose/epidemiologia , Adulto , Feminino , Humanos , Imunoglobulina G/sangue , Imunoglobulina M/sangue , Peru/epidemiologia , Gravidez , Complicações Parasitárias na Gravidez/diagnóstico , Prevalência , Fatores de Risco , Estudos Soroepidemiológicos , Fatores Socioeconômicos , Toxoplasmose/diagnóstico
19.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-33735000

RESUMO

INTRODUCTION: Although the absence of memory impairment was considered among the diagnostic criteria to differentiate Alzheimer's disease (AD) from Behavioural Variant of Frontotemporal Dementia (bvFTD), current and growing evidence indicates that a significant percentage of cases of bvFTD present with episodic memory deficits. In order to compare the performance profile of the naming capacity and episodic memory in patients with AD and bvFTD the present study was designed. METHODS: Cross-sectional and analytical study with control group (32 people). The study included 42 people with probable AD and 22 with probable bvFTD, all over 60 years old. Uniform Data Set instruments validated in Spanish were used: Multilingual Naming Test (MINT), Craft-21 history and Benson's complex figure, among others. RESULTS: A higher average age was observed among the patients with AD. The naming capacity was much lower in patients with bvFTD compared to patients with AD, measured according to the MINT and the nouns/verbs naming coefficient. All patients with bvFTD, 73.81% of those with AD and only 31.25% of the control group failed to recognise Benson's complex figure. All differences were statistically significant (p <0.001). RESULTS: This study confirms the amnesic profile of patients with AD and reveals the decrease in naming capacity in patients with bvFTD, an area of language that is typically affected early on with executive functions, according to recent findings. CONCLUSIONS: Patients with AD perform worse in verbal and visual episodic memory tasks, while patients with bvFTD perform worse in naming tasks. These findings open the possibility of exploring the mechanisms of prefrontal participation in episodic memory, typically attributed to the hippocampus.

20.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-33735029

RESUMO

OBJECTIVES: The aim of this work is to evaluate the factors related to depression in older adults seen in the health centres of Chiclayo. METHODS: An observational, prospective, analytical study that included adults over 60 years of age residing in the Chiclayo district (Peru). The abbreviated depression scale of Yesavage was used. Univariate analysis was performed, presented as frequencies and percentages, as well as bivariate analysis using chi-squared. Adjusted logistic regressions were calculated for age and gender. RESULTS: A total of 302 older adults participated in this study. The median age was 73 years. It was found that 30.8% had depressive signs, and 18.2% had some degree of cognitive deterioration. Just over half (160, 52.98%) had a socio-familial risk, and 29 (9.60%) were detected in the dependent functional assessment. There was an association in the analysis of depression, age group, cognitive impairment, socio-family assessment (P<.05). In the multivariate analysis adjusted for age and gender, cognitive deterioration and socio-family assessment continued to be risk factors. CONCLUSIONS: Depression is associated with a deficiency in the cognitive state, with familial partner risk being an influential factor that may be preventable.

SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...