Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 168
J Neurosurg Spine ; : 1-8, 2020 Aug 21.
Artigo em Inglês | MEDLINE | ID: mdl-32823260


OBJECTIVE: The objective of this study was to determine the publication rate of abstracts presented at the annual meetings of the AANS/CNS Section on Disorders of the Spine and Peripheral Nerves (Spine Summit). METHODS: The authors used a search algorithm in PubMed to determine the publication rate of abstracts presented at the Spine Summit from 2007 to 2012. The variables assessed were presentation modality, topic, meeting year, publication year, destiny journal and its 5-year impact factor (IF), country, and citation count (retrieved from the Scopus database). RESULTS: One thousand four hundred thirty-six abstracts were analyzed; 502 were oral presentations and 934 were digital poster presentations. The publication rate was 53.97% (775/1436). The mean time from presentation to publication was 1.35 ± 1.97 years (95% CI 1.21-1.49 years). The mean citation count of published articles was 40.55 ± 55.21 (95% CI 36.66-44.44). Oral presentations had a higher publication rate (71.51%, 359/502) than digital posters (44.54%, 416/934; OR 3.13, 95% CI 2.48-3.95, p < 0.001). Oral presentations had a higher number of citations (55.51 ± 69.00, 95% CI 48.35-62.67) than digital posters (27.64 ± 34.88, 95% CI 24.28-31.00, p < 0.001). The mean IF of published articles was 3.48 ± 2.91 (95% CI 3.27-3.70). JNS: Spine (191/775, 24.64%), Spine (103/775, 13.29%), and Neurosurgery (56/775, 7.23%) had the greatest number of published articles. The US represented the highest number of published articles (616/775, 79.48%). CONCLUSIONS: The publication rate of the Spine Summit is among the highest compared to other spine meetings. Many of the abstracts initially presented at the meeting are further published in high-IF journals and had a high citation count. Therefore, the Spine Summit maintains its high standards of scientific papers, which reflects the high quality of the research performed in the spine surgery field in North America.

World Neurosurg ; 2020 Jun 27.
Artigo em Inglês | MEDLINE | ID: mdl-32599181


OBJECTIVE: To evaluate access to the technologies and education needed to perform minimally invasive spine surgery (MISS) in Latin America. METHODS: We designed a questionnaire to evaluate surgeons' practice characteristics, access to different technologies, and training opportunities for MISS techniques. The survey was sent to members and registered users of AO Spine Latin from January 6-20, 2020. The major variables studied were nationality, specialty (orthopedics or neurosurgery), level of hospital (primary, secondary, tertiary), number of surgeries performed per year by the spine surgeon, types of spinal pathologies commonly managed, and number of MISS performed per year. Other variables involved specific access to different technologies: intraoperative fluoroscopy, percutaneous screws, cages, tubular retractors, microscopy, intraoperative computed tomography, neuronavigation imaging, and bone morphogenetic protein. Finally, participants were asked about main obstacles to performing MISS and their access to education on MISS techniques in their region. RESULTS: The questionnaires were answered by 306 members of AO Spine Latin America across 20 different countries. Most answers were obtained from orthopedic surgeons (57.8%) and those with over 10 years of experience (42.4%). Most of the surgeons worked in private practice (46.4%) and performed >50 surgeries per year (44.1%), but only 13.7% performed >50 MISS per year, mainly to manage degenerative pathologies (87.5%). Most surgeons always had access to fluoroscopy (79%). Only 26% always had access to percutaneous screws, 24% to tubular retractors, 34.3% to cages (anterior lumbar interbody fusion, lateral lumbar interbody fusion, or transforaminal lumbar interbody fusion), and 43% to microscopy. Regarding technologies, 71% reported never having access to navigation, 83% computed tomography, and 69.3% bone morphogenetic protein. The main limitations expressed for widely used MISS technologies were the high implant costs (69.3%) and high navigation costs (49.3%). Most surgeons claimed access to online education activities (71%), but only 44.9% reported access to face-to-face events and 28.8% to hands-on activities, their limited access largely because the courses were expensive (62.7%) or few courses were available on MISS in their region (51.3%). CONCLUSIONS: Most surgeons in Latin America have limited resources to perform MISS, even in private practice. The main constraints are implant costs, access to technologies, and limited face-to-face educational opportunities.

Int J Med Inform ; 135: 104065, 2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-31927468


INTRODUCTION: A dataset with patient information allows a comparison between different clinical treatments in many fields of medicine as well as the effective use of medical resources. Patient-reported outcome measures (PROMs) collect data directly from patients for use in clinical practice by helping decision making and tailoring treatments according to the patients' needs. The authors present a novel database to overcome data collection related barriers, calculating automatically the questionnaire results, displayed in graphics on the patients' dashboard in real time, and focused on the active follow of the patients. OBJECTIVE: To present electronic health record database for monitoring clinical or surgical interventions and assess the usability. METHODOLOGY: Process modeling and specification of system requirements were performed using the Iconix methodology along with the Post-Study System Usability Questionnaire (PSSUQ) to validate the usability and usefulness of the proposed system. The system and the questionnaires were performed in three languages: Brazilian Portuguese, Spanish, and English. RESULTS: The database enables researchers to use the questionnaires defining the time of data collection according to the needs of each clinical study. The system facilitates the patient answers without any personal interference from smartphones, tablets or computers. The questionnaire scores were calculated automatically in real time and displayed in graphics on the patients' dashboard. The evaluation of the usability and usefulness of the developed database used 8 people divided into two equal groups (4 physicians and 4 medical students). CONCLUSION: The proposed electronic health record database allows a friendly and flexible use of PROMs according to the population, needs in practice and clinical settings. The platform promotes active and direct data collection from patients and physicians in English, Portuguese and Spanish.

Registros Eletrônicos de Saúde/estatística & dados numéricos , Medidas de Resultados Relatados pelo Paciente , Brasil , Bases de Dados Factuais , Seguimentos , Humanos , Idioma , Inquéritos e Questionários
Eur Spine J ; 29(5): 927-936, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-31696338


PURPOSE: To investigate whether the World Health Organization Safety Surgical Checklist (SSC) is an effective tool to reduce complications in spinal surgery. METHODS: We retrospectively evaluated the clinical and radiological charts prospectively collected from patients who underwent a spinal surgery procedure from January 2010 to December 2012. The aim of this study was to compare the incidence of complications between two periods, from January to December 2010 (without checklist) and from January 2011 and December 2012 (with checklist), in order to assess the checklist's effectiveness. RESULTS: The sample size was 917 patients with an average of 30-month follow-up. The mean age was 52.88 years. The majority of procedures were performed for oncological diseases (54.4%) and degenerative diseases (39.8%). In total, 159 complications were detected (17.3%). The overall incidence of complications for trauma, infectious pathology, oncology, and degenerative disease was 22.2%, 19.2%, 18.4%, and 15.3%, respectively. No correlation was observed between the type of pathology and the complication incidence. We observed a reduction in the overall incidence of complications following the introduction of the SSC: In 2010 without checklist, the incidence of complications was 24.2%, while in 2011 and 2012, following the checklist introduction, the incidence of complications was 16.7% and 11.7%, respectively (mean 14.2%). CONCLUSIONS: The SSC seems to be an effective tool to reduce complications in spinal surgery. We propose to extend the use of checklist system also to the preoperative and postoperative phases in order to further reduce the incidence of complications. These slides can be retrieved under Electronic Supplementary Material.

Telemed J E Health ; 26(5): 576-583, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-31314689


Introduction: Remote patient monitoring or telemonitoring aims at improving patient care through digitally transmitted health-related data. That allows early detection of disease decompensation and intervention, patient education and improves patient-physician relationship. Despite its relevance, there are no comprehensive reviews evaluating the variables discussed by clinical studies on telemonitoring. Methods: A systematic literature search of PubMed was performed to identify studies about telemonitoring published between 2000 and 2018. These had to be case reports with >5 cases, comparative or clinical studies/trials. The following variables were evaluated: year of publication, author's country, discussed topic, objective of study, follow-up time, number of telemonitoring patients, primary outcome, use of teleconsultation and tele-education, presence of a control group, effectiveness of telemonitoring, telemonitoring strategies, and level of evidence. Results: After screening 947 records, 272 articles were included. The review showed a growing number of publications over the years, with 43.0% being published between 2015 and 2018, providing generally positive results (76.8%). The United States was responsible for 38.2% of articles. Cardiovascular disease was the topic of 47.8% of studies, whereas surgical pathologies and postoperative care represented only 2.6%. Wireless devices or smartphone apps were the most popular strategy (75.7%), with 17.6% of studies employing tele-education and 24.6% employing teleconsultation measures. Most publications were OCEBM Level of Evidence 2 (73.5%). Conclusion: Telemonitoring appears to maximize patient care and effectiveness of treatment. The number of publications illustrates the growing interest in the matter. Telemonitoring has yet to be evaluated in the setting of postoperative care and surgical pathologies.

J Biomech Eng ; 2019 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-31633166


In this study, we present a numerical methodology to minimize the bone mass loss in a femur with a total hip arthroplasty procedure considering uncertainties in the material parameters by a RBDO (Reliability-Based Design Optimization) procedure. A genetic algorithm (GA) was applied as the optimization method and a three-dimensional finite element model associated with a bone remodeling procedure was developed to describe the femoral bone behavior (internal and external). An example of a femoral prosthesis is presented for the discussion of the methodologies employed, and the corresponding reliability level is evaluated. Constraints on the strength of all materials are inputs to the optimization model. The proposed methodology is compared with a deterministic optimization (DO) and the results show that it is important to consider the uncertainties in this kind of problem since the reliability index found a posteriori is considerably lower.

Coluna/Columna ; 18(3): 240-245, July-Sept. 2019. graf
Artigo em Inglês | LILACS | ID: biblio-1019780


ABSTRACT Around 6% of the elderly population over 65 years of age are affected by adult spinal deformity (ASD). The increasing prevalence of ASD with aging has prompted discussion regarding the use of various techniques for its treatment, such as surgery and conservative treatment. The objective of this study is to investigate whether surgical treatment demonstrates significant benefits as compared to conservative treatment. A literature review was conducted, focusing on the most relevant papers on the topic published in the last five years. Surgical treatment, which costs an average of US$ 99,114 per procedure, enables almost instant improvement of the pain and disability of ASD. The rate of perioperative complications in ASD is approximately 7.5%, and the average improvement in back pain is 6.2 times higher in the surgical approach than in conservative treatment. In addition, the use of modern operative techniques, such as minimally invasive surgery (MIS), reduces the complications and greatly improves patients' quality of life, compared to open surgery. Therefore, the expected benefits of surgical treatment meets the patient's expectations by eliminating the pain caused by ASD. Although surgical treatment has a higher cost and a greater risk of complications, the use of minimally invasive techniques give the ASD patient a better quality of life. Level of evidence III; Non-Systematic Review.

RESUMO Adultos com deformidade na coluna (ASD) representam cerca de 6% da população idosa com mais de 65 anos de idade. Assim, a crescente prevalência da doença com o envelhecimento leva à uma discussão sobre o uso de várias técnicas para tratar ASD, como cirurgia e tratamento conservador. O objetivo deste estudo é verificar se os benefícios do tratamento cirúrgico mostram melhora significativa em relação ao tratamento conservador. Foi realizada uma revisão da literatura dos trabalhos mais relevantes dos últimos 5 anos, que eram pertinentes ao tema do presente estudo. Com um custo médio de US$ 99,114 por procedimento, o tratamento cirúrgico permite a melhora instantânea da dor e da incapacidade causada aos ASD e apresenta uma taxa de complicações perioperatórias de aproximadamente 7.5% . A média de melhora na dor nas costas é 6.2 vezes maior na abordagem cirúrgica do que o apresentado pelo tratamento conservador. Além disso, o uso de modernas técnicas operatórias, como a cirurgia minimamente invasiva (MIS), que permite a diminuição das complicações e uma melhora muito superior na qualidade de vida, diferentemente da cirurgia aberta. Assim, o ganho esperado com o tratamento cirúrgico atende as expectativas do paciente ao eliminar o processo doloroso nos ASD. A escolha pelo tratamento cirúrgico, apesar de apresentar um custo mais elevado e um maior risco de complicações, e o uso de técnicas minimamente invasivas, permitem ao paciente ASD uma melhor qualidade de vida. Nível de evidência III; Revisão não Sistemática.

RESUMEN Alrededor del 6% de las personas mayores de 65 años de edad se ven afectadas por la deformidad espinal adulta (DEA). La creciente prevalencia de DEA con el envejecimiento ha impulsado la discusión sobre el uso de diversas técnicas para su tratamiento, como la cirugía y el tratamiento conservador. El objetivo de este estudio es investigar si el tratamiento quirúrgico demuestra beneficios significativos en comparación con el tratamiento conservador. Una revisión de la literatura, centrada en los artículos más relevantes se llevó a cabo en los últimos cinco años. Con un costo promedio de US$ 99.114, el tratamiento quirúrgico permite una mejora casi instantánea del dolor y la discapacidad de de DEA. La tasa de complicaciones perioperatorias la DEA es aproximadamente del 7,5%, y la mejoría promedio en el dolor de espalda es 6,2 veces mayor en el tratamiento quirúrgico que en el tratamiento conservador. Además, el uso de técnicas quirúrgicas modernas, como cirugía mínimamente invasiva (CMI) reduce las complicaciones y mejora en gran medida la calidad de vida de los pacientes en comparación con la cirugía abierta. Por lo tanto, los beneficios esperados del tratamiento quirúrgico cumplen con las expectativas del paciente al eliminar el dolor causado por la DEA. Aunque el tratamiento quirúrgico tiene un costo más elevado y un mayor riesgo de complicaciones, el uso de técnicas mínimamente invasivas permite que el paciente con DEA tenga una mejor calidad de vida. Nivel de evidencia III; Revisión no Sistemática.

Humanos , Qualidade de Vida , Doenças da Coluna Vertebral , Cirurgia Geral , Terapêutica , Custos e Análise de Custo , Tratamento Conservador
World Neurosurg ; : e339-e345, 2019 Jul 26.
Artigo em Inglês | MEDLINE | ID: mdl-31356976


INTRODUCTION: Publication rate can indirectly assess the quality of research presented in scientific meetings. Considering presentations at orthopedic surgery and neurosurgery meetings, 10.5-66% of abstracts are published in scientific journals. Publication rate of abstracts presented at CSS Meetings is unknown. The objective of this study was to evaluate the publication rate of abstracts presented at the Canadian Spine Society(CSS) Annual Meetings from 2005to2014. METHODS: In October2018, a systematic PubMed search was performed using title and authors of all abstracts presented at CSS Meetings from 2005 to 2014. The following information was retrieved from the articles and abstracts: year, type of presentation, publication in PubMed, time from presentation to final publication, journal and its impact factor(IF). RESULTS: A total of 621 abstracts were presented at CSS meetings from 2005 to 2014. Publication rate in PubMed was 54.8%(N=340/621). Oral presentations were more likely to be published than poster presentations(63.8%vs44.0%; OR=1.45; CI95%=1.20-1.75; P<0.0001). The mean time from presentation to publication was 1.76 years(±1.93). The 340 identified articles were published in 87 different journals. Most common journals were Spine(N=75; 22.1%), The Spine Journal(N=40;11.8%), and Journal of Neurosurgery:Spine(N=28;8.2%). IF ranged from 0.18 to 47.66(mean=3.73±4.68). IF of articles presented orally were higher than those presented as poster(P=0.038). CONCLUSIONS: The CSS scientific meeting maintain along the years a steady high quality research presentations as manifested by its significant publication rate(54.8%) in medical journals with mean IF of 3.73. In comparison with other spine scientific meetings, publication rates of abstracts presented at CSS meeting is amongst the highest.

Coluna/Columna ; 18(2): 138-143, June 2019. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1011951


ABSTRACT Objective: Spondylodiscitis is still a frequent pathology among neurosurgical services, and its correct treatment involves infectious, neurological and orthopedic goals. The authors describe the protocol and report the diagnostic and therapeutic results after its implementation. Methods: A prospective prognostic study (Level I) including patients with primary spondylodiscitis treated in the Neurosurgical Service of Cristo Redentor Hospital from January 2014 to March 2018. Demographic, spine, infectious and treatment-related variables were analyzed. The numerical variables are presented as mean and standard deviation or median and interquartile range (according to their parametricity), and are compared by the student's t-Test or Mann-Whitney U Test, respectively. Results: Thirty seven patients were included. The sexes were evenly distributed, with predominantly Caucasians, and a mean age of 56.89 ±15.33. Hypertension and type 2 diabetes were the most frequent comorbidities. Vertebral lumbar level was the most involved segment. Pathogens were identified in 34 cases (91%), with Staphylococcus aureus being the most prevalent, followed by Koch Bacilli. Inflammatory markers are higher in pyogenic infections at hospital admission, but lower at hospital discharge when compared to tuberculous discitis (p<0.01). Mean hospital stay was higher in the pyogenic group. Conclusion: The protocol described has a high diagnostic level of the pathogen, with cure of infection and satisfactory neurologic outcome in all cases. Level of Evidence I, Diagnostic Studies - Investigating a Diagnostic Test.

RESUMO Objetivo: Espondilodiscite é uma patologia frequente nas enfermarias neurocirúrgicas, cujo tratamento adequado envolve questões infecciosas, neurológicas e ortopédicas. Os autores descrevem um protocolo reportando resultados diagnósticos e terapêuticos após sua implementação. Método: Estudo prognóstico prospectivo (Nível I) incluindo pacientes com espondilodiscite primária tratados de janeiro 2014 a março de 2018. Variáveis relacionadas a dados demográficos, vertebrais, infecciosos e terapêuticos foram analisados. Variáveis numéricas serão apresentadas como média e desvio padrão ou mediana e intervalo interquartil (conforme sua parametricidade) e analisadas com Teste T-Student ou Teste Mann-Whittney, respectivamente. Resultados: 37 pacientes foram incluídos, cuja média de idade foi 56.89 ±15.33. Hipertensão arterial e Diabetes foram as comorbidades mais prevalentes. O segmento lombar foi o mais acometido. Houve identificação do patógeno em 34 casos (91%), sendo o Staphylococcus aureus o mais frequente, seguido pelo Bacilo de Koch. Os marcadores inflamatórios foram maiores no grupo de discite piogênica no momento da admissão hospitalar, mas com valores inferiores aos da discite tuberculosa na alta hospitalar (p<0.01). A média de internação hospitalar foi maior no grupo piogênico. Conclusão: O protocolo descrito tem elevada taxa de identificação do patógeno com critérios de cura infecciosa e desfecho neurológico satisfatório em todos os casos descritos. Nível de Evidência I, Estudos diagnósticos - Investigação de um exame para diagnóstico.

RESUMEN Objetivo: La espondilodiscitis sigue siendo una patología frecuente en los servicios de neurocirugía y su tratamiento correcto incluye objetivos infecciosos, neurológicos y ortopédicos. Los autores describen un protocolo e informan los resultados diagnósticos y terapéuticos después de su implementación. Métodos: Estudio pronóstico prospectivo (Nivel I) que incluyó pacientes con espondilodiscitis primaria tratados en el Servicio de Neurocirugía del Hospital Cristo Redentor desde enero de 2014 hasta marzo de 2018. Se analizaron variables demográficas, vertebrales, infecciosas y relacionadas con el tratamiento. Las variables numéricas se presentan como promedio y la desviación estándar o mediana y rango intercuartil (según su parametricidad) y se comparan mediante la prueba t de Student o la prueba U de Mann-Whitney, respectivamente. Resultados: Se incluyeron 37 pacientes. Los sexos se distribuyeron uniformemente, con predominancia de caucásicos y una edad promedio de 56,89 ± 15,33. La hipertensión y la diabetes tipo 2 fueron las comorbilidades más frecuentes. El nivel lumbar fue el segmento más afectado. Se identificaron patógenos en 34 casos (91%), siendo el Staphylococcus aureus el más frecuente, seguido por el bacilo de Koch. Los marcadores inflamatorios fueron más en las infecciones piógenas en el hospital, pero más bajos en el alta hospitalaria en comparación con la discitis tuberculosa (p < 0,01). La estancia hospitalaria promedio fue mayor en el grupo piógeno. Conclusiones: El protocolo descrito tiene un alto nivel de diagnósticos del patógeno, con curación de la infección y resultados neurológicos satisfactorios en todos los casos. Nivel de Evidencia I, Estudios de diagnósticos - Investigación de un examen para diagnóstico.

Humanos , Coluna Vertebral , Discite , Infecções , Neurocirurgia
Mater Sci Eng C Mater Biol Appl ; 99: 957-968, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30889770


Engineered skin coverings have been adopted clinically to support extensive and deep wounds that result in fewer healthy skin remaining and therefore take longer to heal. Nonetheless, these biomaterials demand intensive labor and an expensive final cost. In comparison to conventional bandages, which do not meet all the requirements of wound care, electrospun fiber mats could potentially provide an excellent environment for healing. In this work, we developed two nanostructured scaffolds based on polyamide-6 (PA-6) to be tested as a wound covering in a rat model of full-thickness incisional wound healing. The central idea was to create a bioconstruct that is simple to implement and biologically safe, with a high survival rate, which provides physical support and biological recognition for new functional tissues. An unmodified PA-6 and a soybean-modified PA-6 were employed as nanofibrillar matrices in this study. The biomaterials showed a dimensional homology to natural extracellular matrix components and neither in vitro toxicity nor in vivo side effects. Both polymeric scaffolds were resistant to the sterilization process and could promote the attachment of 3T3 fibroblast cells, besides successfully incorporating the growth factor PDGF-BB, which had its bioactivity extended for up to 12 h under simulated conditions. The modification of PA-6 chains with a fatty acid derivative increased the scaffold's surface free energy, favoring cell proliferation, collagen formation, and ECM secretion. These results confirm the potential of these materials as a topical dermal covering for skin regeneration.

Caprolactama/análogos & derivados , Polímeros/farmacologia , Pele/patologia , Soja/química , Cicatrização/efeitos dos fármacos , Células 3T3 , Animais , Becaplermina/farmacologia , Caprolactama/farmacologia , Adesão Celular/efeitos dos fármacos , Microambiente Celular/efeitos dos fármacos , Chlorocebus aethiops , Masculino , Membranas Artificiais , Camundongos , Nanopartículas/química , Nanopartículas/ultraestrutura , Ratos Wistar , Pele/efeitos dos fármacos , Fatores de Tempo , Células Vero
Regen Med ; 13(5): 611-626, 2018 07 01.
Artigo em Inglês | MEDLINE | ID: mdl-30132392


AIM: Disc herniation is a spine disease that leads to suffering and disability. Discectomy is a Janus-faced approach that relieves pain symptoms but leave the intervertebral discs predisposed to herniation. This systematic review discussed the mechanical and biological requirements for a polyurethane-based biomaterial to be used in annular repair. METHODS: Search strategy was performed in PubMed, Web of Science and Scopus databases to define the main mechanical properties, biological findings and follow-up aspects of these biomaterials. The range was limited to articles published from January 2000 to December 2017 in English language. RESULTS: The search identified 82 articles. From these, a total of 18 articles underwent a full-text analysis, and 16 studies were included in the review. CONCLUSION: The polyurethane presents suitable properties to be used as an engineered solution to re-establish the microenvironment and biomechanical features of the intervertebral disc.

Anel Fibroso , Deslocamento do Disco Intervertebral/terapia , Poliuretanos/uso terapêutico , Regeneração/efeitos dos fármacos , Animais , Humanos
Global Spine J ; 8(3): 303-310, 2018 May.
Artigo em Inglês | MEDLINE | ID: mdl-29796379


Study Design: Cross-sectional study. Objectives: To continue the line of a previous publication using steroid for acute spinal cord injury (SCI) by spine surgeons from Latin America (LA) and assess the current status of methylprednisolone (MP) prescription in Europe (EU), Asia Pacific (AP), North America (NA), and Middle East (ME) to determine targets for educational activities suitable for each region. Methods: The English version of a previously published questionnaire was used to evaluate opinions about MP administration in acute SCI in LA, EU, AP, NA, and ME. This Internet-based survey was conducted by members of AOSpine. The questionnaire asked about demographic features, background with management of spine trauma patients, routine administration of MP in acute SCI, and reasons for MP administration. Results: A total of 2659 responses were obtained for the electronic questionnaire from LA, EU, AP, NA, and ME. The number of spine surgeons that treat SCI was 2206 (83%). The steroid was used by 1198 (52.9%) surgeons. The uses of MP were based predominantly on the National Acute Spinal Cord Injury Study III study (n = 595, 50%). The answers were most frequently given by spine surgeons from AP, ME, and LA. These regions presented a statistically significant difference from North America (P < .001). The number of SCI patients treated per year inversely influenced the use of MP. The higher the number of patients treated, the lower the administration rates of MP observed. Conclusions: The study identified potential targets for educational campaigns, aiming to reduce inappropriate practices of MP administration.

World Neurosurg ; 112: e823-e829, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-29410173


BACKGROUND: Spine surgeons are exposed to high amounts of radiation from fluoroscopic procedures during their lifetime. In this study, we evaluated spine surgeons' knowledge of and attitude regarding radiation exposure during spine surgery. METHODS: We developed a questionnaire including questions about surgeons' characteristics and knowledge of and attitude regarding radiation exposure during spine surgery. A survey was performed with the members of AOSpine Latin America. The main variables studied were specialty, years of experience, surgeon's position during fluoroscopy, and practices to reduce the patient's and surgeon's radiation exposure during surgery. The results were analyzed and compared among different specialties, levels of experience, and countries of origin. RESULTS: The questionnaire was answered by 371 members of AOSpine Latin America from different countries. The sample was mostly from orthopedic surgeons (57.1%) and surgeons in practice for longer than 10 years (54.2%). Thyroid lead protection was used by 64.2% of the spine surgeons, lead glasses by 20.2%, and lead gloves by 7%. A dosimeter badge was never or only rarely used by 75.7%. The correct answer for surgeon position during lateral lumbar fluoroscopy was reported by only one-third of the surgeons. The reported rate of thyroid protector use was higher in surgeons from Brazil and Colombia compared with surgeons from Mexico and Argentina (P < 0.001), whereas the use of pulsed-mode fluoroscopy was higher in Mexico and Argentina compared with Brazil and Colombia (P < 0.0001). CONCLUSIONS: Future efforts toward implementing educational programs in Latin America focused on safety strategies are needed to minimize intraoperative radiation exposure.

Conhecimentos, Atitudes e Prática em Saúde , Neurocirurgiões , Cirurgiões Ortopédicos , Exposição à Radiação , Estudos Transversais , Humanos , América Latina , Exposição Ocupacional/prevenção & controle , Exposição à Radiação/prevenção & controle , Lesões por Radiação/prevenção & controle , Inquéritos e Questionários
World Neurosurg ; 113: e232-e238, 2018 May.
Artigo em Inglês | MEDLINE | ID: mdl-29432942


BACKGROUND: Infertility is one of many complications of spinal cord injury (SCI) in male patients, who are often at the peak of their reproductive life. This study evaluated effects of hyperbaric therapy (HT) on quality of sperm of rats with SCI and correlated the findings with histologic analysis of the testicles. METHODS: This experimental study comprised 18 rats that were submitted to SCI with a MASCIS Impactor and randomly allocated to either a HT or a control group. Testicular biopsies were performed on the first and 28th day of the study; 4 parameters were evaluated: concentration of sperm per mL, number of round cells per field, number of inflammatory cells per field (peroxidase [Endtz] test), and sperm viability (hypo-osmotic swelling test). RESULTS: There was no difference in sperm concentration between the HT group (P = 0.41) and control group (P = 0.74) during 28 days. From day 1 to day 28, sperm viability decreased twice as much in the control group (P = 0.001) compared with the HT group (P = 0.017). There was no difference between the groups in mean sperm concentration and number of round and inflammatory cells. On the first day, there was no difference in sperm viability between groups. There was a significantly higher (P = 0.001) percentage of viable sperm in the HT group (86.8 ± 5.6) compared with the control group (48.8 ± 21.8) on day 28. CONCLUSIONS: SCI increased the number of round and inflammatory cells and diminished sperm viability in both groups. HT promoted greater sperm viability in rats with SCI.

Oxigenação Hiperbárica , Infertilidade Masculina/terapia , Espermatozoides/citologia , Traumatismos da Medula Espinal/complicações , Animais , Biópsia , Sobrevivência Celular , Infertilidade Masculina/etiologia , Infertilidade Masculina/patologia , Inflamação , Masculino , Estresse Oxidativo , Distribuição Aleatória , Ratos , Ratos Wistar , Análise do Sêmen , Contagem de Espermatozoides , Testículo/patologia
Spine (Phila Pa 1976) ; 43(8): E442-E447, 2018 04 15.
Artigo em Inglês | MEDLINE | ID: mdl-28837532


STUDY DESIGN: A controlled laboratory study. OBJECTIVE: The aim of this study was to analyze the effectiveness of hyperbaric therapy (HT) using mild and moderate models of spinal cord injury (SCI). SUMMARY OF BACKGROUND DATA: SCI can cause permanent impairment with socioeconomic consequences. The motor deficit occurs by two mechanisms: destruction of neuronal cells and local inflammatory response, resulting in hypoxia. HT acts by increasing oxygen in the injured area. METHODS: Thoracic laminectomy was performed in 72 female Wistar rats. The MASCIS impactor was used at 12.5 mm (n = 35) and 25 mm (n = 35) of height to perform, respectively, mild and moderate SCI. Muscle strength was assessed through the Basso, Beattie, and Bresnahan scale (BBB) on days 1, 7, 14, 21, and 28 after SCI. The animals were randomized into five subgroups with seven animals each: (1) control group had SCI without HT; (2) HT 30 minutes after SCI; (3) HT 30 minutes after SCI and daily for 7 days; (4) HT 12 hours after SCI; and (5) HT 12 hours after SCI and daily for 7 days. HT was performed at 2.5 atm for 1 hour. RESULTS: There was a linear relationship between injury severity and motor deficit until day 21, with similar BBB scores on day 28. A pattern of uniform lesions was observed in the mild SCI, with lower variation of BBB when compared with moderate SCI. All animals that underwent HT had significant improvement in motor function and histology when compared with control group. Regardless of the injury model, animals submitted to 7-day protocols had an early improvement in motor function and a smaller area of histological injury. CONCLUSION: The present study reported that the sooner HT is begun after mild and moderate SCI and the larger the number of sessions, the greater and earlier is the motor recovery and smaller is the tissue injury. LEVEL OF EVIDENCE: N/A.

Oxigenação Hiperbárica/métodos , Atividade Motora/fisiologia , Recuperação de Função Fisiológica/fisiologia , Traumatismos da Medula Espinal/fisiopatologia , Traumatismos da Medula Espinal/terapia , Animais , Feminino , Oxigenação Hiperbárica/tendências , Distribuição Aleatória , Ratos , Ratos Wistar , Traumatismos da Medula Espinal/patologia , Vértebras Torácicas