Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 9 de 9
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Int J Public Health ; 66: 1604235, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34483811

RESUMO

Objectives: This study aimed to investigate the associations between air pollution exposure and pediatric outpatient visits for dry eye disease (DED) in Shenzhen, China. Methods: Generalized additive models were utilized to explore the acute effects of air pollution exposure on pediatric outpatient visits for DED. Results: Single-day lag exposures to NO2, O3, PM2.5, and PM10 were associated with DED outpatient visits at lag days 0, 6, 4 and 2. Relative risks (RRs) for DED given a 10-µg/m3 increase in NO2, O3, PM2.5, and PM10 concentrations were 1.062[95% confidence interval (CI) 1.003, 1.123], 1.015(95% CI 1.001, 1.031), 1.052(95% CI 1.001, 1.115), and 1.038 (95% CI 1.002, 1.076), respectively. RR for DED given a 10-µg/m3 increase in NO2 over cumulative lag days 0-1 was 1.075 (95% CI 1.009, 1.147), and RR for DED given a 10-µg/m3 increase in PM10 over cumulative lag days 0-4 was 1.051 (95% CI 1.003, 1.102). Conclusion: The observed associations between air pollution and outpatient visits for DED may provide evidence for policy makers to consider implementing measures to reduce the risk of DED owing to air pollution in China.


Assuntos
Poluição do Ar , Assistência Ambulatorial , Síndromes do Olho Seco , Exposição Ambiental , Poluição do Ar/efeitos adversos , Assistência Ambulatorial/estatística & dados numéricos , Criança , China/epidemiologia , Síndromes do Olho Seco/epidemiologia , Síndromes do Olho Seco/terapia , Exposição Ambiental/efeitos adversos , Exposição Ambiental/estatística & dados numéricos , Humanos
2.
Front Public Health ; 9: 679406, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34277546

RESUMO

Background: Previous studies have demonstrated the embryotoxicity and fetotoxicity of thallium (Tl). However, the effects of prenatal exposure to Tl on birth weight and placental weight and the mediating role of placental weight in the association of Tl with birth weight remain unclear. Methods: We recruited 2,748 participants from the ongoing Prenatal Environment and Offspring Health Cohort (PEOH Cohort) study, which was initiated in 2016 in Guangzhou, China. The Tl concentrations in maternal urine samples collected during the first and third trimester were determined by inductively coupled plasma mass spectrometry. Birth weight and placental weight were extracted from maternal medical records. Results: Pregnant women exposed to the highest tertile of Tl in the first trimester (ß = -42.7 g, 95% CI: -82.3, -3.1 g) and third trimester (ß = -50.6 g, 95% CI: -99.0, -2.3 g) had babies with lower birth weights than those exposed to the lowest tertile. We also found significant negative associations of exposure to Tl concentrations in the first and third trimester with placental weight. Mediation analyses showed that 50.3% (95% CI: 15.9, 79.2%) and 33.5% (95% CI: 1.3, 80.3%) of the effects of Tl exposure in the first and third trimester on birth weight were mediated by decreased placental weight. Conclusion: Our results suggest that prenatal exposure to Tl is negatively associated with birth weight and that this association may be mediated by decreased placental weight.


Assuntos
Efeitos Tardios da Exposição Pré-Natal , Tálio , Peso ao Nascer , China/epidemiologia , Estudos de Coortes , Feminino , Humanos , Lactente , Exposição Materna/efeitos adversos , Placenta , Gravidez , Estudos Prospectivos
3.
Environ Res ; 200: 111457, 2021 09.
Artigo em Inglês | MEDLINE | ID: mdl-34089745

RESUMO

Although strict lockdown measurements implemented during the COVID-19 pandemic have dramatically reduced the anthropogenic-based emissions, changes in air quality and its health impacts remain unclear in China. We comprehensively described air pollution during and after the lockdown periods in 2020 compared with 2018-2019, and estimated the mortality burden indicated by the number of deaths and years of life lost (YLL) related to the air pollution changes. The mean air quality index (AQI), PM10, PM2.5, NO2, SO2 and CO concentrations during the lockdown across China declined by 18.2 (21.2%), 27.0 µg/m3 (28.9%), 10.5 µg/m3 (18.3%), 8.4 µg/m3 (44.2%), 13.1 µg/m3 (38.8%), and 0.3 mg/m3 (27.3%) respectively, when compared to the same periods during 2018-2019. We observed an increase in O3 concentration during the lockdown by 5.5 µg/m3 (10.4%), and a slight decrease after the lockdown by 3.4 µg/m3 (4.4%). As a result, there were 51.3 (95%CI: 32.2, 70.1) thousand fewer premature deaths (16.2 thousand during and 35.1 thousand after the lockdown), and 1066.8 (95%CI: 668.7, 1456.8) thousand fewer YLLs (343.3 thousand during and 723.5 thousand after the lockdown) than these in 2018-2019. Our findings suggest that the COVID-19 lockdown has caused substantial decreases in air pollutants except for O3, and that substantial human health benefits can be achieved when strict control measures for air pollution are taken to reduce emissions from vehicles and industries. Stricter tailored policy solutions of air pollution are urgently needed in China and other countries, especially in well-developed industrial regions, such as upgrading industry structure and promoting green transportation.


Assuntos
Poluentes Atmosféricos , Poluição do Ar , COVID-19 , Poluentes Atmosféricos/análise , Poluição do Ar/análise , China/epidemiologia , Controle de Doenças Transmissíveis , Monitoramento Ambiental , Humanos , Pandemias , Material Particulado/análise , Material Particulado/toxicidade , SARS-CoV-2
4.
J Affect Disord ; 292: 552-558, 2021 09 01.
Artigo em Inglês | MEDLINE | ID: mdl-34147967

RESUMO

BACKGROUND: Parental attitudes towards the vaccines play a key role in the success of the herd immunity for the COVID-19. Psychological health seems to be a controversial determinant of vaccine hesitancy and remains to be investigated. This study attempted to measure parental psychological distress, attitudes towards the COVID-19 vaccine, and to explore the potential associations. METHODS: An online survey using convenience sampling method was conducted among parents within the school public health network of Shenzhen. Demographic information and attitudes towards COVID-19 vaccination were collected. The Patient Health Questionnaire (PHQ-4) was applied to measure psychological distress. RESULTS: Overall, 4,748 parents were included (average age: 40.28, standard deviation: 5.08). More than one fifth of them demonstrated psychological distress, in which only 3.3% were moderate to severe symptom. The proportions of COVID-19 vaccine hesitancy for themselves, their spouses, and their children were 25.2%, 26.1%, and 27.3%, respectively. Parents with psychological distress were more likely to suffer vaccine hesitancy for themselves (OR: 1.277, 95%CI: 1.091~1.494), for their spouses (OR:1.276, 95%CI: 1.088~1.496) and children (OR:1.274, 95%CI: 1.092~1.486). These associations tended to be more significant among parents with mild or severe psychological distress. LIMITATION: Non-random sampling limited the generalization of our findings to all parents. CONCLUSION: Parents had a low level of psychological distress but relatively high willingness of COVID-19 vaccination when there was no local epidemic but persistent risk of imported cases. Targeted health education and intervention strategies should be provided to people with vaccine hesitancy, especially for those who are susceptible to psychological distress.


Assuntos
COVID-19 , Angústia Psicológica , Adulto , Vacinas contra COVID-19 , Criança , China/epidemiologia , Estudos Transversais , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Pais , Aceitação pelo Paciente de Cuidados de Saúde , SARS-CoV-2 , Vacinação
5.
Environ Epidemiol ; 5(2): e139, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-33870013

RESUMO

Selenium (Se) is an essential element and also toxic at an excessive level for human body. However, few studies have investigated adverse effects of Se exposure on birth weight and placental weight. Methods: All participants were selected from the Prenatal Environment and Offspring Health cohort conducted in 2016 in Guangzhou, China. Se in each participant was measured by inductively coupled plasma mass spectrometry in their urine samples. The urinary Se concentrations were corrected by creatinine and transformed by natural logarithm (ln-Se). Multiple-linear regression models were applied to estimate the associations among Se exposure levels, placenta weight, and birth weight. Results: A total of 2758 mother-newborn pairs were included in this study. Each interquartile range (0.53 µg/g creatinine) increment in urine ln-Se concentration during the first trimester was associated with a mean 21.7 g (95% CI = -41.3g to -2.1g) decrease in birth weight and 3.6g (95% CI = -6.3g to -0.9g) decrease in placental weight. Compared with the lowest quartile (Q1) of ln-Se concentrations during the first trimester, significantly lower birth weight was found in the highest quartile (Q4) (ß = -45.7g; 95% CI = -90.7g to -0.7g). Similar dose-response associations with birthweight and placental weight were found for Se exposure during the third trimester. Mediation analyses showed that 44.2% and 18.2% of the effects of Se exposure in first and third trimester on birth weight were mediated by decreased placental weight, respectively. Conclusion: Maternal Se exposure during pregnancy was negatively associated with birth weight, the reduction of placental weight may partially mediate the association of prenatal Se exposure with birth weight.

6.
Zhen Ci Yan Jiu ; 45(10): 818-22, 2020 Oct 25.
Artigo em Chinês | MEDLINE | ID: mdl-33788448

RESUMO

OBJECTIVE: To observe the effect of electroacupuncture(EA) on the pain behavior and prostaglandin E2 (PGE2), calcitonin gene-related peptide (CGRP) and substance P (SP) in the spinal cord dorsal horn and dorsal root ganglia (DRG) of rats with knee osteoarthritis (KOA), so as to explore the mechanisms of EA underlying improvement of chronic pain in KOA rats. METHODS: Thirty-two female SD rats were randomly divided into blank group, control group, model group and EA group, with 8 rats in each group. Rats in the control group were injected with 50 µL of 0.9% sodium chloride solution into the left knee joint cavity, and rats in the model and EA groups were injected with 50 µL of Monosodium iodoacetate in the left knee joint. EA(2 Hz/100 Hz, <2 mA) was applied to left "Yanglingquan"(GB34) and "Neixiyan" (EX-LE4) for 15 min, once daily, 5 days a course with a total of 2 courses. Paw withdrawal latency (PWL) and mechanical pain threshold (PWT) were tested by Plantar Test and Von Frey, separately. After the last pain test, the contents of PGE2, CGRP and SP in the left lumbar (L) 3-L5 DRG and L3-L5 spinal dorsal horn were detected by ELISA. RESULTS: Compared with the blank group, the PWL and PWT of the rats in the model group were significantly decreased (P<0.01), and the contents of PGE2, CGRP and SP in the DRG and spinal dorsal horn were significantly increased (P<0.01, P<0.05). There were no statistically significant differences in PWL, PWT, contents of PGE2, CGRP and SP in DRG and spinal dorsal horn between the blank group and the control group (P>0.05). Compared with the model group, the PWL and PWT of rats in the EA group were significantly increased (P<0.01), and the contents of PGE2, CGRP and SP in the DRG and spinal dorsal horn were significantly decreased (P<0.01, P<0.05). CONCLUSION: EA of GB34 and EX-LE4 can reduce the levels of pain-related factors PGE2, CGRP and SP in the DRG and spinal dorsal horn, thereby relieving spinal hyperalgesia in rats with KOA.


Assuntos
Eletroacupuntura , Osteoartrite do Joelho , Animais , Feminino , Gânglios Espinais , Osteoartrite do Joelho/genética , Osteoartrite do Joelho/terapia , Dor , Ratos , Ratos Sprague-Dawley , Medula Espinal , Corno Dorsal da Medula Espinal
7.
Wei Sheng Yan Jiu ; 47(3): 406-412, 2018 May.
Artigo em Chinês | MEDLINE | ID: mdl-30082008

RESUMO

OBJECTIVE: To explore the pollution characteristics and possible influence factors of PM_(2. 5)in Shenzhen in 2016. METHODS: The dynamic characters of PM_(2. 5)mass concentration were analyzed using air quality monitoring and meteorology observation data. The correlations between PM_(2. 5)and other affecting factors, e. g. gas pollutions and meteorology factors, were discussed. A multiple linear regression model was built to reveal the impacts of those factors on PM_(2. 5)concentrations in Shenzhen City using the air quality monitoring and meteorology observation data. RESULTS: The mass concentration of PM_(2. 5)was(27. 02±13. 88)µg/m~3, and the ratios of PM_(2. 5)/PM_(10)was(0. 62±0. 08)in Shenzhen City. Significant positive correlations existed between PM_(2. 5)concentration and main airpollutants(NO_2, SO_2, CO and O_3)(P<0. 05). A significant negative correlation existed between PM_(2. 5) concentration and temperature, relative humidity(P<0. 05), and also a significant positive correlation between atmospheric pressure and PM_(2. 5)concentration. The multiple linear regression showed that air pollutants(NO_2, SO_2, CO, and O_3)and atmospheric pressure could explain 86. 7% of the variations of PM_(2. 5)concentration. The standard regression coefficient of CO in the model was the highest(0. 439). CONCLUSION: PM_(2. 5)pollution was relatively light in Shenzhen City, and PM_(2. 5)was the main component of inhalable particulate matter. Atmospheric pressure and other pollutants in the atmosphere were the main influencing factors of PM_(2. 5)concentration, and CO was the major contributor to PM_(2. 5)concentration rising in Shenzhen City.


Assuntos
Poluentes Atmosféricos , Poluição do Ar , Monitoramento Ambiental , Material Particulado/efeitos adversos , China , Cidades , Humanos , Estações do Ano
8.
Wei Sheng Yan Jiu ; 47(2): 270-276, 2018 Mar.
Artigo em Chinês | MEDLINE | ID: mdl-29903282

RESUMO

OBJECTIVE: To investigate spatial-temporal distribution characteristics of air quality indexes( AQI) in Shenzhen City and provide scientific basis for control of air pollution. METHODS: The monitoring data of AQI collected at the 19 monitoring posts in Shenzhen City from 2014 to 2016 were pooled and analyzed, and daily, seasonal and annual means of AQI at each monitoring post were forked out. The theory of spatial autocorrelation analysis was adopted in analyzing strength of the spatial autocorrelation and spatial clustering patterns of AQI. RESULTS: The median of AQI of Shenzhen City was50. 0, and the air quality level of Shenzhen City was level 2. PM_(2. 5) was the primary air pollutant in 2014, and O_3 was the primary air pollutant in 2015 and 2016 respectively. From the time distribution, the air quality in Shenzhen City was the worst in the winter but the best in the summer, and the air quality in night was worse than the day. Spatial autocorrelation analysis showed that there was positive spatial autocorrelation of AQI in Shenzhen. The global moran's I of AQI was 0. 167( Z = 2. 000, P < 0. 05), and the greary coefficient was 0. 801( Z = 1. 711, P < 0. 05). The local moran's I of AQI was 1. 027( P < 0. 05) in Guangming New District. The moran scatter plot of AQI in Guangming New District was in the first quadrant, and appeared to be in a high-high clustering pattern. The moran scatter plot of AQI in Yantian District was in the third quadrant, and appeared to be in a low-low clustering pattern. CONCLUSION: The air quality of Shenzhen City was better. PM_(2. 5) and O_3 were the primary air pollutant. It is necessary to emphasize and strengthen the prevention and control of air pollution in Winter, especially in several administrative districts of the northwest of Shenzhen City.


Assuntos
Poluentes Atmosféricos/efeitos adversos , Poluição do Ar , Monitoramento Ambiental , China , Cidades , Utensílios Domésticos , Humanos , Estações do Ano
9.
Acta Crystallogr Sect E Struct Rep Online ; 68(Pt 3): o714, 2012 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-22412598

RESUMO

The title compound, C(24)H(30)O(8), was obtained by reaction of ethyl 4-hy-droxy-benzoate with 1,2-dichloro-ethane. The mol-ecule occupies a crystallographic inversion center, with its central ethyl-ene bridge in an anti conformation. The other ethyl-ene bridge has a gauche conformation, with the corresponding O-C-C-O torsion angle being 74.2 (1)°. The benzene rings are almost coplanar with the adjacent eth-oxy-carbonyl groups, with an r.m.s. deviation of 0.078 Å.

SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...