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1.
Front Oncol ; 12: 955668, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36212413

RESUMO

Background: Artificial intelligence (AI) is more and more widely used in cancer, which is of great help to doctors in diagnosis and treatment. This study aims to summarize the current research hotspots in the Application of Artificial Intelligence in Cancer (AAIC) and to assess the research trends in AAIC. Methods: Scientific publications for AAIC-related research from 1 January 1998 to 1 July 2022 were obtained from the Web of Science database. The metrics analyses using bibliometrics software included publication, keyword, author, journal, institution, and country. In addition, the blustering analysis on the binary matrix was performed on hot keywords. Results: The total number of papers in this study is 1592. The last decade of AAIC research has been divided into a slow development phase (2013-2018) and a rapid development phase (2019-2022). An international collaboration centered in the USA is dedicated to the development and application of AAIC. Li J is the most prolific writer in AAIC. Through clustering analysis and high-frequency keyword research, it has been shown that AI plays a significantly important role in the prediction, diagnosis, treatment and prognosis of cancer. Classification, diagnosis, carcinogenesis, risk, and validation are developing topics. Eight hotspot fields of AAIC were also identified. Conclusion: AAIC can benefit cancer patients in diagnosing cancer, assessing the effectiveness of treatment, making a decision, predicting prognosis and saving costs. Future AAIC research may be dedicated to optimizing AI calculation tools, improving accuracy, and promoting AI.

2.
Ecotoxicol Environ Saf ; 247: 114218, 2022 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-36279636

RESUMO

Microplastics (MPs) in natural environments undergo complex aging processes, changing their interactions with coexisting antibiotics, and posing unpredictable ecological risks. However, the joint toxicity of aged MPs (aMPs) and antibiotics to bacteria, especially at the molecular level, is unclear. In this study, non-thermal plasma technology was used to simultaneously simulate various radical oxidation and physical reactions that occur naturally in the environment, breaking the limitation of simple aging process in laboratory aging technologies. After aging, we investigated the altered properties of aMPs, their interactions with ciprofloxacin (CIP), and the molecular responses of E. coli exposed to pristine MPs (13.5 mg/L), aMPs (13.5 mg/L), and CIP (2 µg/L) individually or simultaneously. aMPs bound far more CIP to their surfaces than pristine MPs, especially in freshwater ecosystems. Notably, the growth of E. coli exposed to aMPs alone was inhibited, whereas pristine MPs exposure didn't affect the growth of E. coli. Moreover, the most differentially expressed genes in E. coli were induced by the coexposure of aMPs and CIP. Although E. coli depended on chemotaxis to improve its flagellar rotation and escaped the stress of pollutants, the coexposure of aMPs and CIP still caused cell membrane damage, oxidative stress, obstruction of DNA replication, and osmotic imbalance in E. coli. This study filled the knowledge gap between the toxicity of aMPs and pristine MPs coexisting with antibiotics at the transcription level, helping in the accurate assessment of the potential risks of MPs to the environment.


Assuntos
Microplásticos , Poluentes Químicos da Água , Microplásticos/toxicidade , Ciprofloxacina/toxicidade , Plásticos , Escherichia coli/genética , Escherichia coli/metabolismo , Ecossistema , Poluentes Químicos da Água/toxicidade , Poluentes Químicos da Água/metabolismo , Antibacterianos/toxicidade
3.
Plants (Basel) ; 11(17)2022 Aug 25.
Artigo em Inglês | MEDLINE | ID: mdl-36079591

RESUMO

To explore the impact of nitrogen (N) rate during the wheat season and N fertilizer management during the rice season on carbon and soil nutrient pools in paddy soil, a wheat-rice rotation system for 2 successive years was implemented. In the rotation system, a conventional N rate (Nc; 150 kg/ha) and a reduced N rate (Nr; 120 kg/ha) were applied in the wheat season. Based on an application rate of 150 kg/hm2 N in the rice season, three N management models were applied, in which the application ratio of base:tiller:panicle fertilizer was 20%:20%:60% in treatment M1, 30%:30%:40% in treatment M2, and 40%:40%:20% in treatment M3. Zero N was used as the control (M0). Experimental results indicate that, under Nc, the M2 management model during the rice season, improvements were seen in paddy soil urease, organic carbon, and annual yield relative to other conditions. The average organic matter and total N associated with the M2 rice management model and conventional N application during the wheat season were 5.13% and 4.95% higher, respectively, relative to the use of a reduced N application rate during the wheat season. Similarly, the average total carbon content and annual yields were 6.61% and 5.56% higher under the model M2 with conventional N application during the wheat season, respectively, relative to reduced N application after the two-year study period. These findings indicate that production and carbon fixation in paddy fields can be optimized through a conventional N application rate during the wheat season, and an M2 N management model during the rice season in southern China under a wheat-rice rotation system.

4.
Antimicrob Agents Chemother ; 66(10): e0014022, 2022 10 18.
Artigo em Inglês | MEDLINE | ID: mdl-36165615

RESUMO

In orthopedic oncology, the implant of a megaprosthetic device is standard of care after large-scale tumor resection involving segmental removal of bone. Infection remains the leading cause of implant failure, often resulting in major morbidity. Perioperative antibiotic practices for megaprosthetic reconstructions are not standardized and are based on guidelines for conventional joint arthroplasties. This study aims to evaluate the efficacy of current prophylactic strategies for megaprosthetic reconstructions. We conducted a retrospective review of megaprosthetic reconstructions performed at Duke University from 2001 to 2021. Logistic regression with GEE was used to assess whether a prolonged course of postoperative antibiotics is associated with infection risk. We assessed the microbial profile and corresponding susceptibilities of megaprosthetic infections through record review. Additionally, we designed a pharmacokinetic subgroup analysis using liquid chromatography-tandem mass spectrometry to quantify antibiotic concentrations in surgical tissue. Wilcoxon rank-sum tests were used to correlate tissue concentrations with infection risk. Out of 184 cases, 23 (12.5%) developed infection within 1 year. Extended postoperative antibiotics were not significantly associated with infection risk (P = 0.23). Among 18 culture-positive cases, 4 (22.2%) were caused by cefazolin-susceptible organisms. Median bone and muscle concentrations of cefazolin among cases that developed postoperative infection (0.065 ng/mL and 0.2 ng/mL, respectively) were significantly lower than those of cases that did not (0.42 ng/mL and 1.95 ng/mL, P < 0.01 and P = 0.03). This study is the first to comprehensively assess aspects of perioperative prophylaxis for megaprosthetic reconstructions. Extending postoperative antibiotics did not reduce infection risk. We detected a high frequency of cefazolin nonsusceptible organisms among postoperative infections. Additionally, intraoperative antibiotic tissue concentrations may be predictive of later infection. Future studies ought to examine optimal drug choices and dosing strategies.


Assuntos
Antibioticoprofilaxia , Cefazolina , Humanos , Cefazolina/uso terapêutico , Antibacterianos/uso terapêutico , Estudos Retrospectivos , Infecção da Ferida Cirúrgica/prevenção & controle , Infecção da Ferida Cirúrgica/tratamento farmacológico
5.
Chemosphere ; 307(Pt 3): 135940, 2022 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-35963381

RESUMO

The ecotoxicity of microplastics (MPs) to soil animals is widely recognized; however, most studies have only focused on conventional MPs. This study compared the effects of various concentrations (0.5%, 1%, 2%, 5%, 7%, and 14%, w/w) of polyethylene (PE) and biodegradable polylactic acid (PLA) MPs on oxidative stress and gut microbes in Eisenia fetida (E. fetida) from two different soils (black and yellow soils). The results indicated that the activities of superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), glutathione S-transferase (GST), and acetylcholinesterase (AchE) decreased after exposure to PE and PLA MPs for 14 days, whereas malondialdehyde (MDA) levels increased. This level of decrease or increase exhibited a "decrease-increase" trend with increasing MP exposure doses. After 28 days, the activities of SOD, CAT, POD, AchE, and GST increased, whereas MDA levels decreased, and the level of increase or decrease increased with increasing MP dose. The integrated biological response index revealed that the toxic effects of MPs were concentration-dependent, and MP concentration was more important than MP type or soil type. The toxicity of PE MPs was generally higher than that of PLA MPs on day 14, with no significant difference on day 28. Moreover, MPs did not alter the dominant gut microbiota of E. fetida, but altered the relative abundances of Actinobacteriota, Bacteroidota, Ascomycota, and Rozellomycota. Furthermore, different gut microbial phyla exhibited discrepant responses to MPs. Our results demonstrated that both conventional and biodegradable MPs induced oxidative stress in E. fetida, and biodegradable MPs showed no less toxicity compared to conventional MPs. Additionally, MP-induced toxic effects did not differ significantly between black and yellow soils, suggesting that MP-induced toxic effects were less affected by soil type.


Assuntos
Oligoquetos , Poluentes do Solo , Acetilcolinesterase , Animais , Catalase/metabolismo , Glutationa Transferase/metabolismo , Malondialdeído , Microplásticos , Estresse Oxidativo , Peroxidase/metabolismo , Plásticos/toxicidade , Poliésteres , Polietileno/farmacologia , Solo , Poluentes do Solo/toxicidade , Superóxido Dismutase/metabolismo
6.
Nat Commun ; 13(1): 4821, 2022 08 16.
Artigo em Inglês | MEDLINE | ID: mdl-35974023

RESUMO

Global warming is increasingly exacerbating biodiversity loss. Populations locally adapted to spatially heterogeneous environments may respond differentially to climate change, but this intraspecific variation has only recently been considered when modelling vulnerability under climate change. Here, we incorporate intraspecific variation in genomic offset and ecological niche modelling to estimate climate change-driven vulnerability in two bird species in the Sino-Himalayan Mountains. We found that the cold-tolerant populations show higher genomic offset but risk less challenge for niche suitability decline under future climate than the warm-tolerant populations. Based on a genome-niche index estimated by combining genomic offset and niche suitability change, we identified the populations with the least genome-niche interruption as potential donors for evolutionary rescue, i.e., the populations tolerant to climate change. We evaluated potential rescue routes via a landscape genetic analysis. Overall, we demonstrate that the integration of genomic offset, niche suitability modelling, and landscape connectivity can improve climate change-driven vulnerability assessments and facilitate effective conservation management.


Assuntos
Mudança Climática , Ecossistema , Animais , Biodiversidade , Aves/genética , Genômica
7.
Front Oncol ; 12: 918349, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35992886

RESUMO

Background: The coronavirus disease 2019 (COVID-19) pandemic is disrupting routine medical care of cancer patients, including those who have cancer or are undergoing cancer screening. In this study, breast cancer management during the COVID-19 pandemic (BCMP) is reviewed, and the research trends of BCMP are evaluated by quantitative and qualitative evaluation. Methods: In this study, published studies relating to BCMP from 1 January 2020 to 1 April 2022 were searched from the Web of Science database (WoS). Bibliometric indicators consisted of publications, research hotspots, keywords, authors, journals, institutions, nations, and h-index. Results: A total of 182 articles investigating BCMP were searched. The United States of America and the University of Rome Tor Vergata were the nation and the institution with the most publications on BCMP. The first three periodicals with leading published BCMP studies were Breast Cancer Research and Treatment, Breast, and In Vivo. Buonomo OC was the most prolific author in this field, publishing nine articles (9/182, 4.94%). The co-keywords analysis of BCMP suggests that the top hotspots and trends in research are screening, surgery, rehabilitation, emotion, diagnosis, treatment, and vaccine management of breast cancer during the pandemic. The hotspot words were divided into six clusters, namely, screening for breast cancer patients in the pandemic, breast cancer surgery in the pandemic, recovery of breast cancer patients in the pandemic, motion effect of the outbreak on breast cancer patients, diagnosis and treatment of breast cancer patients in the pandemic, and vaccination management for breast cancer patients during a pandemic. Conclusion: BCMP has received attention from scholars in many nations over the last 3 years. This study revealed significant contributions to BCMP research by nations, institutions, scholars, and journals. The stratified clustering study provided the current status and future trends of BCMP to help physicians with the diagnosis and treatment of breast cancer through the pandemic, and provide a reference for in-depth clinical studies on BCMP.

8.
Int J Endocrinol ; 2022: 2319660, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35795844

RESUMO

Objective: Inflammation is related to the occurrence and development of various cancers. This study was designed to explore the role of peripheral blood platelet count, neutrophil-lymphocyte ratio (NLR), platelet count-lymphocyte count ratio (PLR), systemic inflammation index (SII), and other inflammatory markers in predicting benign and malignant Thyroid Imaging Reporting and Data System (TI-RADS) grade 3 thyroid nodules. Methods: In this retrospective study, 514 patients with TI-RADS grade 3 thyroid nodules were enrolled. According to the pathological results, the patients were divided into the benign and malignant nodule groups. We compared the clinical characteristics between the two groups and analysed the influencing factors for malignant thyroid nodules by univariate and stepwise multivariate logistic regression analyses and then analysed the cutoff value of each influencing factor according to the receiver operating characteristic curve. Results: The leukocyte count, neutrophil count, platelet count, NLR, PLR, and SII of the malignant nodule group were significantly higher than those of the benign nodule group (P < 0.05), the age and the diameter of nodule of the malignant nodule group were significantly smaller than those of the benign nodule group (P < 0.05). After excluding the influence of confounding factors, SII (odds ratio (OR) = 1.006; 95% confidence interval (CI) = 1.003-1.008; P < 0.001), PLR (odds ratio (OR) = 0.981; 95% confidence interval (CI) = 0.981-0.992; P < 0.05), leukocyte count (odds ratio (OR) = 0.654; 95% confidence interval (CI) = 0.466-0.892; P < 0.05), and age (OR = 0.969; 95% CI = 0.954-0.985; P < 0.001) were independent risk factors for malignant thyroid nodules, and the cutoff value of SII and PLR in predicting benign and malignant thyroid nodules were 545.63 × 109/L and 138.63. Conclusion: This study showed that peripheral blood SII, PLR, leukocyte count and age were independent risk factors for malignant thyroid nodules, and the combination of these can better predict benign and malignant thyroid nodules, which can further guide the diagnosis and treatment of TI-RADS grade 3 thyroid nodules.

9.
Nanomaterials (Basel) ; 12(14)2022 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-35889658

RESUMO

The Te-free compound Bi2SeS2 is considered as a potential thermoelectric material with less environmentally hazardous composition. Herein, the effect of iodine (I) substitution on its thermoelectric transport properties was studied. The electrical conductivity was enhanced due to the increased carrier concentration caused by the carrier provided defect Ise. Thus, an enhanced power factor over 690 µWm-1K-2 was obtained at 300 K by combining a moderate Seebeck coefficient above 150 µV/K due to its large effective mass, which indicated iodine was an effective n-type dopant for Bi2SeS2. Furthermore, a large drop in the lattice thermal conductivity was observed due to the enhanced phonon scattering caused by nanoprecipitates, which resulted in a low total thermal conductivity (<0.95 Wm-1K-1) for all doped samples. Consequently, a maximum ZT value of 0.56 was achieved at 773 K for a Bi2Se1-xIxS2 (x = 1.1%) sample, a nearly threefold improvement compared to the undoped sample.

10.
Nano Lett ; 22(14): 5898-5908, 2022 07 27.
Artigo em Inglês | MEDLINE | ID: mdl-35839459

RESUMO

The development of platinum(Pt)-drugs for cancer therapy has stalled, as no new Pt-drugs have been approved in over a decade. Packaging small molecule drugs into nanoparticles is a way to enhance their therapeutic efficacy. To date, there has been no direct comparison of relative merits of the choice of Pt oxidation state in the same nanoparticle system that would allow its optimal design. To address this lacuna, we designed a recombinant asymmetric triblock polypeptide (ATBP) that self-assembles into rod-shaped micelles and chelates Pt(II) or enables covalent conjugation of Pt(IV) with similar morphology and stability. Both ATBP-Pt(II) and ATBP-Pt(IV) nanoparticles enhanced the half-life of Pt by ∼45-fold, but ATBP-Pt(IV) had superior tumor regression efficacy compared to ATBP-Pt(II) and cisplatin. These results suggest loading Pt(IV) into genetically engineered nanoparticles may yield a new generation of more effective platinum-drug nanoformulations.


Assuntos
Antineoplásicos , Nanopartículas , Neoplasias , Pró-Fármacos , Animais , Antineoplásicos/química , Antineoplásicos/uso terapêutico , Linhagem Celular Tumoral , Cisplatino/química , Cisplatino/uso terapêutico , Camundongos , Nanopartículas/química , Neoplasias/tratamento farmacológico , Neoplasias/genética , Neoplasias/patologia , Peptídeos/uso terapêutico , Platina/química , Pró-Fármacos/química
11.
Artigo em Inglês | MEDLINE | ID: mdl-35862330

RESUMO

Feature selection plays a significant role in computer science; nevertheless, this task is intractable since its search space scales exponentially with the number of dimensions. Motivated by the potential advantages of near-term quantum computing, three graph-theoretic feature selection (GTFS) methods, including minimum cut (MinCut)-based, densest k -subgraph (DkS)-based, and maximal-independent set/minimal vertex cover (MIS/MVC)-based, are investigated in this article, where the original graph-theoretic problems are naturally formulated as the quadratic problems in binary variables and then solved using the quantum approximate optimization algorithm (QAOA). Specifically, three separate graphs are created from the raw feature set, where the vertex set consists of individual features and pairwise measure describes the edge. The corresponding feature subset is generated by deriving a subgraph from the established graph using QAOA. For the above three GTFS approaches, the solving procedure and quantum circuit for the corresponding graph-theoretic problems are formulated with the framework of QAOA. In addition, those proposals could be employed as a local solver and integrated with the Tabu search algorithm for solving large-scale GTFS problems utilizing limited quantum bit resource. Finally, extensive numerical experiments are conducted with 20 publicly available datasets and the results demonstrate that each model is superior to its classical scheme. In addition, the complexity of each model is only O(p n2) even in the worst cases, where p is the number of layers in QAOA and n is the number of features.

12.
Front Oncol ; 12: 809772, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35837112

RESUMO

Background: Radiation-induced lung injury (RILI) is a severe side effect of radiotherapy for non-small cell lung cancer (NSCLC) ,and one of the major hindrances to improve the efficacy of radiotherapy. Previous studies have confirmed that sodium butyrate (NaB) has potential of anti-radiation toxicity. However, the mechanism of the protective effect of NaB against RILI has not yet been clarified. This study aimed to explore the underlying protective mechanisms of NaB against RILI in NSCLC through network pharmacology, molecular docking, molecular dynamic simulations and in vivo experiments. Methods: The predictive target genes of NaB were obtained from the PharmMapper database and the literature review. The involved genes of RILI and NSCLC were predicted using OMIM and GeneCards database. The intersectional genes of drug and disease were identified using the Venny tool and uploaded to the Cytoscape software to identify 5 core target genes of NaB associated with RILI. The correlations between the 5 core target genes and EGFR, PD-L1, immune infiltrates, chemokines and chemokine receptors were analyzed using TIMER 2.0, TIMER and TISIDB databases. We constructed the mechanism maps of the 3 key signaling pathways using the KEGG database based on the results of GO and KEGG analyses from Metascape database. The 5 core target genes and drug were docked using the AutoDock Vina tool and visualized using PyMOL software. GROMACS software was used to perform 100 ns molecular dynamics simulation. Irradiation-induced lung injury model in mice were established to assess the therapeutic effects of NaB. Results: A total of 51 intersectional genes involved in NaB against RILI in NSCLC were identified. The 5 core target genes were AKT1, TP53, NOTCH1, SIRT1, and PTEN. The expressions of the 5 core target genes were significantly associated with EGFR, PD-L1, immune infiltrates, chemokines and chemokine receptors, respectively. The results from GO analysis of the 51 intersectional genes revealed that the biological processes were focused on the regulation of smooth muscle cell proliferation, oxidative stress and cell death, while the three key KEGG pathways were enriched in PI3K-Akt signal pathway, p53 signal pathway, and FOXO signal pathway. The docking of NaB with the 5 core target genes showed affinity and stability, especially AKT1. In vivo experiments showed that NaB treatment significantly protected mice from RILI, with reduced lung histological damage. In addition, NaB treatment significantly inhibited the PI3K/Akt signaling pathway. Conclusions: NaB may protect patients from RILI in NSCLC through multiple target genes including AKT1, TP53, NOTCH1, SIRT1 and PTEN, with multiple signaling pathways involving, including PI3K-Akt pathway, p53 pathway, and FOXO pathways. Our findings effectively provide a feasible theoretical basis to further elucidate the mechanism of NaB in the treatment of RILI.

13.
Front Plant Sci ; 13: 921130, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35812970

RESUMO

Chalkiness, which is highly affected by nitrogen (N) management during grain filling, is critical in determining rice appearance quality and consumer acceptability. We investigated the effects of N application rates 75 (N1), 150 (N2), and 225 (N3) kg ha-1 on the source-sink carbohydrate accumulation and grain filling characteristics of two indica hybrid rice cultivars with different chalkiness levels in 2019 and 2020. We further explored the relationship between grain filling and formation of chalkiness in superior and inferior grains. In this study, carbohydrates in the functional leaves and grains of the two varieties, and grain filling parameters, could explain 66.2%, 68.0%, 88.7%, and 91.6% of the total variation of total chalky grain rate and whole chalkiness degree, respectively. They were primarily concentrated in the inferior grains. As the N fertilizer application rate increased, the chalky grain rate and chalkiness degree of both the superior and inferior grains decreased significantly. This interfered with the increase in total chalky grain rate and chalkiness. Moreover, the carbohydrate content in the functional leaves increased significantly in N2 and N3 compared with that in N1. The transfer of soluble sugar from the leaves to the grains decreased the soluble sugar and increased total starch contents, accelerated the development of grain length and width, increased grain water content, and effectively alleviated the contradiction between source and sink. These changes promoted the carbohydrate partition in superior and inferior grains, improved their average filling rate in the middle and later stages, optimized the uniformity of inferior grain fillings, and finally led to the overall reduction in rice chalkiness.

14.
ACS Appl Mater Interfaces ; 14(28): 31986-31997, 2022 Jul 20.
Artigo em Inglês | MEDLINE | ID: mdl-35793154

RESUMO

Antimony sulfide-selenide (Sb2(S,Se)3) is a promising light-harvesting material for stable and high-efficiency thin-film photovoltaics (PV) because of its excellent light-harvesting capability, abundant elemental storage, and excellent stability. This study aimed to expand the application of Sb2(S,Se)3 solar cells with a substrate structure as a flexible or tandem device. The use of a hydrothermal method accompanied by a postselenization process for the deposition of Sb2(S,Se)3 film based on the solar cell substrate structure was first demonstrated. The mechanism of postselenization treatment on crystal growth promotion of the Sb2(S,Se)3 film and the defect passivation of the Sb2(S,Se)3 solar cell were revealed through different characterization methods. The crystallinity and the carrier transport property of the Sb2(S,Se)3 film improved, and both the interface defect density of the Sb2(S,Se)3/CdS interface and the bulk defect density of the Sb2(S,Se)3 absorber decreased. Through these above-mentioned processes, the transport and collection of electronics can be improved, and the defect recombination loss can be reduced. By using postselenization treatment to optimize the absorber layer, Sb2(S,Se)3 solar cells with the configuration SLG/Mo/Sb2(S,Se)3/CdS/ITO/Ag achieved an efficiency of 4.05%. This work can provide valuable information for the further development and improvement of Sb2(S,Se)3 solar cells.

15.
World J Surg Oncol ; 20(1): 194, 2022 Jun 11.
Artigo em Inglês | MEDLINE | ID: mdl-35689286

RESUMO

BACKGROUND: Gastric cancer (GC) is the sixth most common cancer. China is one of the most frequent GC occurred countries, and Wuwei, Gansu, is one of the highest incidence area in China. Possible biomarkers of GC susceptibility and prognosis among the population in Wuwei are urgently needed. METHODS: All participants in this study were recruited from the Wuwei Cancer Hospital in Gansu, including 303 patients diagnosed with GC and 200 non-cancer controls. DNA was extracted for further single nucleotide polymorphisms (SNP) genotyping. All SNPs were firstly screened by additive logistic regression model then selected SNPs were subjected to univariate Cox regression analysis and multivariate Cox regression analysis for their associations with GC occurrence. RESULTS: The results showed that 31 SNPs were significantly related to the incidence of GC in Wuwei, Gansu, China. Genotype rs4823921 was significantly related to the overall survival of GC patients and AC/AA genotype of rs4823921 polymorphism was significantly associated with an increased risk of GC in Wuwei population. CONCLUSIONS: Thirty-one SNPs were significantly related to the incidence of GC in Wuwei and rs4823921 genotype AC/AA was significantly associated with poor prognosis of GC patients in Wuwei, Gansu.


Assuntos
Polimorfismo de Nucleotídeo Único , Neoplasias Gástricas , Estudos de Casos e Controles , China/epidemiologia , Predisposição Genética para Doença , Genótipo , Humanos , Prognóstico , Neoplasias Gástricas/diagnóstico , Neoplasias Gástricas/epidemiologia , Neoplasias Gástricas/genética
16.
Front Neurol ; 13: 843909, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35614928

RESUMO

Background: Neuromyelitis optica spectrum disorders seriously hinder social participation. Only clarifying the status of social participation and the factors most strongly influencing it can promote better-targeted support for those with neuromyelitis optica spectrum disorders. Objectives: To explore the factors influencing social participation among persons with neuromyelitis optica spectrum disorders. Methods: 138 persons with neuromyelitis optica were recruited by convenience sampling. They completed the Impact on Participation and Autonomy Questionnaire, and were rated using the Barthel index, the Beck Anxiety Inventory and the Beck Depression Inventory. The data were used to evaluate a generalized linear model predicting social participation. Results: The respondents mostly perceived good or very good possibilities of social participation, but participation outdoors and in social relations were considered more restricted. Ability in the activities of daily living, education level, bladder and bowel dysfunction, and depression were four significant predictors of social participation. Conclusions: Strengthening training in the activities of daily living, continuing education, giving positive psychological support and helping with bladder and bowel problems may help to promote social participation among those with neuromyelitis optica spectrum disorders.

17.
Comput Intell Neurosci ; 2022: 3287068, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35586090

RESUMO

To investigate the effectiveness of identifying patients with Parkinson's disease (PD) from speech signals, various acoustic parameters including prosodic and segmental features are extracted from speech and then the random forest classification (RF) algorithm based on these acoustic parameters is applied to diagnose early-stage PD patients. To validate the proposed method of RF algorithm in early-stage PD identification, this study compares the accuracy rate of RF with that of neurologists' judgments based on auditory test outcomes, and the results clearly show the superiority of the proposed method over its rival. Random forest algorithm based on speech can improve the accuracy of patients' identification, which provides an efficient auxiliary method in the early diagnosis of PD patients.


Assuntos
Doença de Parkinson , Acústica , Algoritmos , Humanos , Doença de Parkinson/complicações , Doença de Parkinson/diagnóstico , Fala
18.
J Environ Manage ; 316: 115232, 2022 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-35569354

RESUMO

Land use planning regulates surface hydrological processes by adjusting land properties with varied evapotranspiration ratios. However, a dearth of empirical spatial information hampers the regulation of place-specific hydrological processes. Therefore, this study proposed a Local Land Use Planning framework for EvapoTranspiration Ratio regulations (ETR-LLUP), which was tested for the developments of spatially-varied land use strategies in the Dongjiang River Basin (DRB) in Southern China. With the first attempt at integrating the Emerging Hot Spots Analysis (EHSA) with the Budyko framework, the spatiotemporal trends of evapotranspiration ratios based on evaporative index and dryness index, from 1992 to 2018, were illustrated. Then, representative land-cover types in each sub-basin were defined using Geographically Weighted Principal Component Analysis, in two wet years (1998 and 2016) and three dry years (2004, 2009, and 2018), which in turn were identified using the Standard Precipitation Index. Finally, Geographically Weighted Regressions (GWRs) were used to detect spatially-varied relationships between land-cover proportions and evaporative index in both dry and wet climates. Results showed that the DRB was consistently a water-limited region from 1992 to 2018, and the situation was getting worse. We also identified the upper DRB as hotspots for hydrological management. Forests and croplands experienced increasingly water stress compared to other vegetation types. More importantly, the spatial results of GWR models enabled us to adjust basin land use by 1) expanding and contracting a combination of 'mosaic natural vegetation' and 'broadleaved deciduous trees' in the western and eastern parts of the basin, respectively; and 2) increasing 'broadleaved evergreen trees' in the upstream parts of the basin. These spatially-varied land use strategies based on the ETR-LLUP framework allow for place-specific hydrological management during both dry and wet climates.


Assuntos
Hidrologia , Rios , China , Mudança Climática , Florestas , Árvores
19.
ACS Appl Mater Interfaces ; 14(22): 25802-25811, 2022 Jun 08.
Artigo em Inglês | MEDLINE | ID: mdl-35609239

RESUMO

Recently, rock-salt lead-free chalcogenide SnTe-based thermoelectric (TE) materials have been considered an alternative to PbTe because of the nontoxic properties of Sn as compared to Pb. However, high carrier concentration that originated from intrinsic Sn vacancies and relatively high thermal conductivity of pristine SnTe lead to poor TE efficiency, which makes room for improving its TE properties. In this study, we present that the Na incorporation into the SnTe matrix is helpful for modifying the electronic band structure, optimization of carrier concentration, introducing dislocations, and kink planes; benefiting from these synergistic effects obviates the disadvantages of SnTe and makes a significant improvement in TE performance. We reveal that Na favorably impacts the structure of electronic bands by valence, conduction band engineering, leading to a nice enhancement in the Seebeck coefficient, which exhibits the highest power factor value of 37.93 µWcm-1 K-2 at 898 K, representing the best result for the SnTe material system. Moreover, a broader phonon spectrum is introduced by new phonon-scattering centers, scattered by dislocations and kink planes which suppressed lattice thermal conductivity to 0.57 Wm-1 K-1 at 898 K, which is much lower than that of pristine SnTe. Ultimately, a maximum ZT of 1.26 at 898 K is achieved in the Sn1.03Te + 3% Na sample, which is 97% higher than that of the pristine SnTe, suggesting that SnTe-based materials are a robust candidate for TE applications specifically, an ideal alternative of lead chalcogenides for TE power generation at high temperatures.

20.
J Clin Lab Anal ; 36(5): e24429, 2022 May.
Artigo em Inglês | MEDLINE | ID: mdl-35403307

RESUMO

OBJECTIVE: The aim of this study was to investigate the diagnostic value of peripheral blood neutrophil-to-lymphocyte ratio (NLR) combined with the thyroid imaging reporting and data system (TIRADS) for benign and malignant thyroid nodules. METHODS: A total of 585 adults were enrolled in the study. The receiver operating characteristic curves were used to determine the optimal cut-off values for NLR and Kwak TIRADS (K-TIRADS) grades, which were 1.87 and 4a, respectively. Thyroid nodules were scored as follows: NLR-K-TIRADS score is 2 (both elevated K-TIRADS grade and NLR), NLR-K-TIRADS score is 1 (one of these was elevated) and NLR-k-TIRADS score is 0 (neither were elevated). RESULTS: The proportions of malignant nodules with NLR-K-TIRADS scores of 2, 1 and 0 were 98.59%, 69.62% and 10.19%, and the difference was statistically significant (p < 0.001). In terms of the sensitivity of diagnosis of malignant nodules, NLR-K-TIRADS 1 tends to increase relative to K-TIRADS grades ≥ 4a; in terms of specificity and positive predictive value for the diagnosis of malignant nodules, NLR-K-TIRADS 2 was significantly higher than K-TIRADS grades ≥ 4a (all p < 0.05). CONCLUSIONS: NLR combined with K-TIRADS grades may be a novel method for screening benign and malignant thyroid nodules.


Assuntos
Nódulo da Glândula Tireoide , Adulto , Humanos , Linfócitos/patologia , Neutrófilos/patologia , Estudos Retrospectivos , Nódulo da Glândula Tireoide/diagnóstico por imagem , Nódulo da Glândula Tireoide/patologia , Ultrassonografia/métodos
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