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1.
Soft Robot ; 2021 Jun 09.
Artigo em Inglês | MEDLINE | ID: mdl-34107748

RESUMO

Robotic grasping has become increasingly important in many application areas such as industrial manufacturing and logistics. Because of the diversity and uncertainty of objects and environments, common grippers with one single grasping mode face difficulties to fulfill all the tasks. Hence, we proposed a soft gripper with multiple grasping modes in this study. The gripper consists of four modular soft fingers integrated with layer jamming structure and tendon-driven mechanism. Each finger's rotating shaft of the base uses a torsional spring to decouple the bending deformation and relative rotation. An octopus-mimicking vacuum sucker is installed in the fingertip to generate suction. The effectiveness of the bending deformation and variable stiffness of the design were proved by finite element simulation. Thus, the control model of the finger was built, and the control strategy of multimode grasping of the gripper was proposed. Three control modes were designed to realize the four anthropomorphic grasping modes, including wrap, pinch, hook, and suck. Furthermore, the grasping performance was evaluated to show the abilities. The experiments indicated the superior performance of the proposed gripper and the multimode grasping ability that satisfies various grasping tasks.

2.
Percept Mot Skills ; : 315125211022709, 2021 Jun 09.
Artigo em Inglês | MEDLINE | ID: mdl-34107802

RESUMO

While prior research has generally found Outdoor Education Programs (OEPs) to be beneficial to adolescents' self-efficacy, we sought to conduct a meta-analytic review of prior studies in this area in order to pinpoint the key elements to OEPs' effectiveness. Following Cooper's guidelines for synthesis research and meta-analysis, we searched six electronic databases for relevant articles: PubMed, Sciencedirect, Medline, PsycArticles, and Behavioral Sciences Collection of EBSCO, and Eric. Selection criteria were: Populations, Interventions, Comparators, Outcomes, Study Design (PICOS), and Methodological Index for Non-randomized Studies (MINORS). We estimated the effect size of the selected studies with a 95% confidence interval (CI), estimated I-squared (I2) for heterogeneity analysis and analyzed publication bias by Egger's test. After excluding many studies, we reviewed 12 studies with 2,642 participants that were deemed to be eligible for final analysis. We discovered a high level of heterogeneity (I-squared value =82.474) in the findings of the selected studies. Our meta-analyses revealed that adolescents participating in OEPs enhanced their self-efficacy (medium effect size; Hedges's g = 0.597) but this enhancement was moderated by participants' mental health status, the length of the experiments, study groups, and the duration of the intervention. We found no evidence of publication bias (Egger: bias = 2.001, 95% CI = -0.736 to 4.739, p = .137). We discussed our research limitations and the theoretical and practical implications of these findings and made recommendations for future research.

3.
J Proteome Res ; 20(6): 3134-3149, 2021 06 04.
Artigo em Inglês | MEDLINE | ID: mdl-34014671

RESUMO

Multiple myeloma is an incurable hematological malignancy that impacts tens of thousands of people every year in the United States. Treatment for eligible patients involves induction, consolidation with stem cell rescue, and maintenance. High-dose therapy with a DNA alkylating agent, melphalan, remains the primary drug for consolidation therapy in conjunction with autologous stem-cell transplantation; as such, melphalan resistance remains a relevant clinical challenge. Here, we describe a proteometabolomic approach to examine mechanisms of acquired melphalan resistance in two cell line models. Drug metabolism, steady-state metabolomics, activity-based protein profiling (ABPP, data available at PRIDE: PXD019725), acute-treatment metabolomics, and western blot analyses have allowed us to further elucidate metabolic processes associated with melphalan resistance. Proteometabolomic data indicate that drug-resistant cells have higher levels of pentose phosphate pathway metabolites. Purine, pyrimidine, and glutathione metabolisms were commonly altered, and cell-line-specific changes in metabolite levels were observed, which could be linked to the differences in steady-state metabolism of naïve cells. Inhibition of selected enzymes in purine synthesis and pentose phosphate pathways was evaluated to determine their potential to improve melphalan's efficacy. The clinical relevance of these proteometabolomic leads was confirmed by comparison of tumor cell transcriptomes from newly diagnosed MM patients and patients with relapsed disease after treatment with high-dose melphalan and autologous stem-cell transplantation. The observation of common and cell-line-specific changes in metabolite levels suggests that omic approaches will be needed to fully examine melphalan resistance in patient specimens and define personalized strategies to optimize the use of high-dose melphalan.

4.
Ann Rheum Dis ; 2021 May 26.
Artigo em Inglês | MEDLINE | ID: mdl-34039624

RESUMO

OBJECTIVES: Circular RNAs (circRNAs) have emerged as significant biological regulators. Herein, we aimed to elucidate the role of an unidentified circRNA (circPDE4B) that is reportedly downregulated in osteoarthritis (OA) tissues. METHODS: The effects of circPDE4B were explored in human and mouse chondrocytes in vitro. Specifically, RNA pull-down (RPD)-mass spectrometry analysis (MS), immunoprecipitation, glutathione-S-transferase (GST) pull-down, RNA immunoprecipitation and RPD assays were performed to verify the interactions between circPDE4B and the RIC8 guanine nucleotide exchange factor A (RIC8A)/midline 1 (MID1) complex. A mouse model of OA was also employed to confirm the role of circPDE4B in OA pathogenesis in vivo. RESULTS: circPDE4B regulates chondrocyte cell viability and extracellular matrix metabolism. Mechanistically, FUS RNA binding protein (FUS) was found to promote the splicing of circPDE4B, while downregulation of circPDE4B in OA is partially caused by upstream inhibition of FUS. Moreover, circPDE4B facilitates the association between RIC8A and MID1 by acting as a scaffold to promote RIC8A degradation through proteasomal degradation. Furthermore, ubiquitination of RIC8A at K415 abrogates RIC8A degradation. The circPDE4B-RIC8A axis was observed to play an important role in regulating downstream p38 mitogen-activated protein kinase (MAPK) signalling. Furthermore, delivery of a circPDE4B adeno-associated virus (AAV) abrogates the breakdown of cartilage matrix by medial meniscus destabilisation in mice, whereas a RIC8A AAV induces the opposite effect. CONCLUSION: This work highlights the function of the circPDE4B-RIC8A axis in OA joints, as well as its regulation of MAPK-p38, suggesting this axis as a potential therapeutic target for OA.

5.
Appl Opt ; 60(14): 4154-4164, 2021 May 10.
Artigo em Inglês | MEDLINE | ID: mdl-33983168

RESUMO

The LiDAR sensor has been widely used for reconstruction in urban scenes. However, the current registration method makes it difficult to find stable 3D point correspondences from sparse and low overlapping LiDAR point clouds. In the urban situation, most of the LiDAR point clouds have a common flat ground. Therefore, we propose a novel, to the best of our knowledge, multi-level height (MH) maps-based coarse registration method. It requires that source and target point clouds have a common flat ground, which is easily satisfied for LiDAR point clouds in urban scenes. With MH maps, 3D registration is simplified as 2D registration, increasing the speed of registration. Robust correspondences are extracted in MH maps with different height intervals and statistic height information, improving the registration accuracy. The solid-state LiDAR Livox Mid-100 and mechanical LiDAR Velodyne HDL-64E are used in real-data and dataset experiments, respectively. Verification results demonstrate that our method is stable and outperforms state-of-the-art coarse registration methods for the sparse case. Runtime analysis shows that our method is faster than these methods, for it is non-iterative. Furthermore, our method can be extended for the unordered multi-view point clouds.

6.
Artigo em Inglês | MEDLINE | ID: mdl-34043330

RESUMO

Lithium (Li) metal as an anode replacing the traditional graphite could largely enhance the specific energy density of Li batteries. However, the repeated formation of solid electrolyte interfaces on the surface of Li metal upon plating/stripping leads to a low Coulombic efficiency, and the growth of Li dendrites upon cycling probably causes the short circuit or even explosion of the batteries, both of which block the commercial application of Li metal in lithium metal batteries (LMBs). Herein, we report an antidendrite AAO@PVDF-HFP composite separator fabricated by a two-step method, which features the ordered pore channels and the polar groups in the channels. This novel composite separator has a good wettability to the electrolyte, high mechanical properties, and high ionic conductivity. Expectedly, the assembled batteries based on our novel composite separator show many impressive performances. In Li-Li cells, the cycling life up to 1600 h at an areal current density of 2 mA/cm2 can be realized; in Li-Cu cells, the cycling life of more than 1000 h with a high Coulombic efficiency of 99.9% at 1 mA/cm2 can be achieved. More interestingly, the Li/LiFePO4 full batteries constructed by the novel AAO@PVDF-HFP composite separators show a high discharge capacity of 140 mAh/g and weak capacity decays even after 360 cycles. The novel design of the separator with ordered channels and polar groups presents an effective route for developing the next-generation LMBs.

7.
J Opt Soc Am A Opt Image Sci Vis ; 38(4): 504-514, 2021 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-33798179

RESUMO

A zoom camera can change its focal length and track moving objects with an adjustable resolution. To extract precise geometric information for the tracked objects, a zoom camera requires an accurate calibration method. High-precision camera calibration methods, however, usually require a number of control points that are not guaranteed in some practical situations. Most zoom cameras suffer radial distortion. Athough a traditional method can recover an undistorted image with known intrinsic parameters, it fails to work for a zoom camera with an unknown focal length. Motivated by these problems, we propose a two-point calibration method (TPCM). In this scheme, we first propose an approximate focal-invariant radial distortion (AFRD) model. With the AFRD model, an RGB image can be undistorted with an unknown focal length. After that, the TPCM method is presented to estimate the focal length and rotation matrix with only two control points for one image. Synthetic experiments demonstrate that the AFRD model is efficient. In the real data experiment, the mean reprojection error of the TPCM method is less than one pixel, which is smaller than current state-of-the-art methods, and we believe meets the demand for high-precision calibration.

8.
Hereditas ; 158(1): 16, 2021 Apr 27.
Artigo em Inglês | MEDLINE | ID: mdl-33906697

RESUMO

BACKGROUND: CCN1 plays a crucial role in the modulation of cardiovascular diseases. However, whether CCN1 genetic variants are involved in the susceptibility of ACS remains unknown. Hence, the present study investigates the association between CCN1 polymorphisms and ACS among Han and Uygur populations in Xinjiang, China. RESULTS: In this case-control study, 1234 Han (547 ACS patients and 687 controls) and 932 Uygur (471 ACS patients and 461 controls) were genotyped using SNPscanTM for three single-nucleotide polymorphisms (SNPs, rs6576776, rs954353, and rs3753794) of the human CCN1 gene. In the Uygur population, we found that the detected frequencies of the C allele (25.3% vs. 18.3%, P<0.001) and CC genotype (6.4% vs. 3.0%, P=0.001) of rs6576776 were significantly higher in the ACS patients than in the control participants. Differences in rs6576776 regarding the dominant model (CC+CG vs. GG, 44.2% vs. 55.8%, P=0.001) and the recessive model (CC vs. CG+GG, 6.4% vs. 93.6%, P=0.016) were observed between the two groups. The frequencies of the GGC and AGC haplotypes in those with ACS were significantly higher than those in the control group (all P<0.05) in the Uygur population. After adjusting for hypertension, diabetes, lipids and smoking, all of which indicate that the rs6576776 C allele is associated with higher risk of ACS (odds ratio (OR)=1.798, 95% confidence interval (CI), 1.218-2.656, P=0.003). In Han population, neither the distribution of genotypes and alleles of the CCN1 gene three SNPs nor the distribution of haplotypes constructed with the three SNPs exhibited a significant difference between the ACS patients and control participants. CONCLUSIONS: Our study document that the CCN1 gene rs6576776 C allele is associated with higher susceptibility of ACS and that the frequencies of GGC and AGC haplotypes are higher among the Uygur ACS patients.

9.
Sci Rep ; 11(1): 8050, 2021 Apr 13.
Artigo em Inglês | MEDLINE | ID: mdl-33850223

RESUMO

Macrophage migration inhibitory factor (MIF) is an essential mediator of atherosclerotic plaque progression and instability leading to intracoronary thrombosis, therefore contributing to coronary artery disease (CAD). In this study, we investigated the relationship between MIF gene polymorphism and CAD in Chinese Han population. Three single nucleotide polymorphisms (SNP, rs755622, rs1007888 and rs2096525) of MIF gene were genotyped by TaqMan genotyping assay in 1120 control participants and 1176 CAD patients. Coronary angiography was performed in all CAD patients and Gensini score was used to assess the severity of coronary artery lesions. The plasma levels of MIF and other inflammatory mediators were measured by ELISA. The CAD patients had a higher frequency of CC genotype and C allele of rs755622 compared with that in control subjects (CC genotype: 6.5% vs. 3.9%, P = 0.008, C allele: 24.0% vs. 20.6%, P = 0.005). The rs755622 CC genotype was associated with an increased risk of CAD (OR: 1.804, 95%CI: 1.221-2.664, P = 0.003). CAD patients with a variation of rs755622 CC genotype had significantly higher Gensini score compared with patients with GG or CG genotype (all P < 0.05). In addition, the circulating MIF level was highest in CAD patients carrying rs755622 CC genotype (40.7 ± 4.2 ng/mL) and then followed by GC (37.9 ± 3.4 ng/mL) or GG genotype (36.9 ± 3.7 ng/mL, all P < 0.01). Our study showed an essential relationship between the MIF gene rs755622 variation and CAD in Chinese Han population. Individuals who carrying MIF gene rs755622 CC genotype were more susceptible to CAD and had more severe coronary artery lesion. This variation also had a potential influence in circulating MIF levels.

10.
Pharmacol Res Perspect ; 9(3): e00764, 2021 May.
Artigo em Inglês | MEDLINE | ID: mdl-33929082

RESUMO

Xanthine oxidase (XO) competes with thiopurine S-methyltransferase (TPMT) and hypoxanthine guanine phosphoribosyltransferase (HPRT) to metabolize azathioprine (AZA)/6-mercaptopurine (6-MP) in vivo. A retrospective investigation was performed to detect the activity of XO in thiopurine curative Chinese inflammatory bowel disease (IBD) patients. We also evaluated whether a relationship between XO activity and incidence of thiopurine-induced adverse effects (AEs) existed. Clinical data and blood samples were collected from 140 IBD patients before receiving AZA/6-MP therapy, and the erythrocyte XO activity was measured. The XO activities of all patients were 20.29 ± 4.43 U/g Hb. No sex difference in XO activity was observed (p = .728), and the XO activity showed no difference between the UC and CD patients (p = .082). AEs were observed in 41 (29.3%) patients including leukopenia (26, 18.57%), gastrointestinal intolerance (11, 7.86%), flu-like symptom (5, 3.57%), alopecia (5, 3.57%), and hepatotoxicity (1, 0.71%). XO activity was significantly lower in the patients with AEs than in those without AEs (18.40 ± 3.73 vs. 21.07 ± 4.48 U/g Hb, p = .001), especially in the patients with leukopenia (18.29 ± 3.68 vs. 21.07 ± 4.48 U/g Hb, p = .004). However, no significant difference in XO activity was found between patients with and without other AEs. Decreased XO activity was observed in the patients who developed flu-like symptoms (17.58 ± 3.50 U/g Hb) and alopecia (18.67 ± 2.91 U/g Hb) compared to those who did not, although the differences did not reach statistical significance. These findings suggested that patients with low XO expression might have a high risk of thiopurine-induced toxicity.

11.
Clin Cancer Res ; 2021 Apr 20.
Artigo em Inglês | MEDLINE | ID: mdl-33879459

RESUMO

PURPOSE: Among human cancers that harbor mutant (mt) KRas, some, but not all, are dependent on mt KRas. However, little is known about what drives KRas dependency. EXPERIMENTAL DESIGN: Global phosphoproteomics, screening of a chemical library of FDA drugs, and genome-wide CRISPR/Cas9 viability database analysis were used to identify vulnerabilities of KRas dependency. RESULTS: Global phosphoproteomics revealed that KRas dependency is driven by a cyclin-dependent kinase (CDK) network. CRISPR/Cas9 viability database analysis revealed that, in mt KRas-driven pancreatic cancer cells, knocking out the cell-cycle regulators CDK1 or CDK2 or the transcriptional regulators CDK7 or CDK9 was as effective as knocking out KRas. Furthermore, screening of a library of FDA drugs identified AT7519, a CDK1, 2, 7, and 9 inhibitor, as a potent inducer of apoptosis in mt KRas-dependent, but not in mt KRas-independent, human cancer cells. In vivo AT7519 inhibited the phosphorylation of CDK1, 2, 7, and 9 substrates and suppressed growth of xenografts from 5 patients with pancreatic cancer. AT7519 also abrogated mt KRas and mt p53 primary and metastatic pancreatic cancer in three-dimensional (3D) organoids from 2 patients, 3D cocultures from 8 patients, and mouse 3D organoids from pancreatic intraepithelial neoplasia, primary, and metastatic tumors. CONCLUSIONS: A link between CDK hyperactivation and mt KRas dependency was uncovered and pharmacologically exploited to abrogate mt KRas-driven pancreatic cancer in highly relevant models, warranting clinical investigations of AT7519 in patients with pancreatic cancer.

12.
Cell Death Dis ; 12(3): 226, 2021 03 01.
Artigo em Inglês | MEDLINE | ID: mdl-33649312

RESUMO

Hypertrophic scar (HS) formation is a skin fibroproliferative disease that occurs following a cutaneous injury, leading to functional and cosmetic impairment. To date, few therapeutic treatments exhibit satisfactory outcomes. The mechanical force has been shown to be a key regulator of HS formation, but the underlying mechanism is not completely understood. The Piezo1 channel has been identified as a novel mechanically activated cation channel (MAC) and is reportedly capable of regulating force-mediated cellular biological behaviors. However, the mechanotransduction role of Piezo1 in HS formation has not been investigated. In this work, we found that Piezo1 was overexpressed in myofibroblasts of human and rat HS tissues. In vitro, cyclic mechanical stretch (CMS) increased Piezo1 expression and Piezo1-mediated calcium influx in human dermal fibroblasts (HDFs). In addition, Piezo1 activity promoted HDFs proliferation, motility, and differentiation in response to CMS. More importantly, intradermal injection of GsMTx4, a Piezo1-blocking peptide, protected rats from stretch-induced HS formation. Together, Piezo1 was shown to participate in HS formation and could be a novel target for the development of promising therapies for HS formation.

13.
Chem Soc Rev ; 50(8): 4872-4931, 2021 Apr 26.
Artigo em Inglês | MEDLINE | ID: mdl-33734247

RESUMO

Stimulus-cleavable nanoscale drug delivery systems are receiving significant attention owing to their capability of achieving exquisite control over drug release via the exposure to specific stimuli. Central to the construction of such systems is the integration of cleavable linkers showing susceptibility to one stimulus or several stimuli with drugs, prodrugs or fluorogenic probes on the one hand, and nanocarriers on the other hand. This review summarises recent advances in stimulus-cleavable linkers from various research areas and the corresponding mechanisms of linker cleavage and biological applications. The feasibility of extending their applications to the majority of nanoscale drug carriers including nanomaterials, polymers and antibodies are further highlighted and discussed. This review also provides general design guidelines to incorporate stimulus-cleavable linkers into nanocarrier-based drug delivery systems, which will hopefully spark new ideas and applications.

14.
Environ Pollut ; 278: 116916, 2021 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-33744784

RESUMO

Cold condensation is an important pathway for polycyclic aromatic hydrocarbons (PAHs) depositing at remote alpine lakes after long-range atmospheric transportation. However, in the context of global warming, the obvious temperature rise in the Tibetan Plateau (TP) might have an impact on the air deposition of PAHs by controlling the extent of cold condensation. To investigate the influence of rising temperatures on the atmospheric deposition of PAHs, two dated sedimentary cores from Pumoyum Co Lake (PC) and Selin Co Lake (SC) were collected, respectively and concentrations of 16 individual PAHs were measured. In both PC and SC, the total concentration of 16 PAHs presented relatively lower levels in four historical periods of "hot anomaly" including 1973-1975, 1988-1989, 1998-1999, and 2006-2007. This indicated that the hot temperatures might restrict the atmospheric deposition of PAHs. Besides, the results of the principal component analysis did discriminate those "hot anomalies". As the temperature kept increasing in TP, for low molecular weight PAHs and high molecular weight PAHs, the influence of rising temperatures on the cold condensation was different. Therefore, it was identified that the effect of global warming on the environmental fate of POPs cannot be neglected, especially in alpine regions like TP.


Assuntos
Hidrocarbonetos Policíclicos Aromáticos , Monitoramento Ambiental , Sedimentos Geológicos , Aquecimento Global , Lagos , Hidrocarbonetos Policíclicos Aromáticos/análise , Tibet
15.
Sci Rep ; 11(1): 6811, 2021 03 24.
Artigo em Inglês | MEDLINE | ID: mdl-33762651

RESUMO

High rate of cardiovascular disease (CVD) has been reported among patients with coronavirus disease 2019 (COVID-19). Importantly, CVD, as one of the comorbidities, could also increase the risks of the severity of COVID-19. Here we identified phospholipase A2 group VII (PLA2G7), a well-studied CVD biomarker, as a hub gene in COVID-19 though an integrated hypothesis-free genomic analysis on nasal swabs (n = 486) from patients with COVID-19. PLA2G7 was further found to be predominantly expressed by proinflammatory macrophages in lungs emerging with progression of COVID-19. In the validation stage, RNA level of PLA2G7 was identified in nasal swabs from both COVID-19 and pneumonia patients, other than health individuals. The positive rate of PLA2G7 were correlated with not only viral loads but also severity of pneumonia in non-COVID-19 patients. Serum protein levels of PLA2G7 were found to be elevated and beyond the normal limit in COVID-19 patients, especially among those re-positive patients. We identified and validated PLA2G7, a biomarker for CVD, was abnormally enhanced in COVID-19 at both nucleotide and protein aspects. These findings provided indications into the prevalence of cardiovascular involvements seen in patients with COVID-19. PLA2G7 could be a potential prognostic and therapeutic target in COVID-19.


Assuntos
1-Alquil-2-acetilglicerofosfocolina Esterase/metabolismo , COVID-19/metabolismo , Doenças Cardiovasculares/metabolismo , Macrófagos/metabolismo , 1-Alquil-2-acetilglicerofosfocolina Esterase/sangue , 1-Alquil-2-acetilglicerofosfocolina Esterase/genética , Biomarcadores/metabolismo , COVID-19/epidemiologia , COVID-19/imunologia , COVID-19/patologia , Doenças Cardiovasculares/epidemiologia , Doenças Cardiovasculares/virologia , China/epidemiologia , Mineração de Dados/métodos , Humanos , Macrófagos/imunologia , Macrófagos/patologia , Polimorfismo de Nucleotídeo Único , SARS-CoV-2/isolamento & purificação , Ativação Transcricional , Regulação para Cima
16.
Clin Cancer Res ; 27(9): 2533-2548, 2021 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-33619172

RESUMO

PURPOSE: Covalent inhibitors of KRASG12C specifically target tumors driven by this form of mutant KRAS, yet early studies show that bypass signaling drives adaptive resistance. Although several combination strategies have been shown to improve efficacy of KRASG12C inhibitors (KRASi), underlying mechanisms and predictive strategies for patient enrichment are less clear. EXPERIMENTAL DESIGN: We performed mass spectrometry-based phosphoproteomics analysis in KRASG12C cell lines after short-term treatment with ARS-1620. To understand signaling diversity and cell type-specific markers, we compared proteome and phosphoproteomes of KRASG12C cells. Gene expression patterns of KRASG12C cell lines and lung tumor tissues were examined. RESULTS: Our analysis suggests cell type-specific perturbation to ERBB2/3 signaling compensates for repressed ERK and AKT signaling following ARS-1620 treatment in epithelial cell type, and this subtype was also more responsive to coinhibition of SHP2 and SOS1. Conversely, both high basal and feedback activation of FGFR or AXL signaling were identified in mesenchymal cells. Inhibition of FGFR signaling suppressed feedback activation of ERK and mTOR, while AXL inhibition suppressed PI3K pathway. In both cell lines and human lung cancer tissues with KRASG12C, we observed high basal ERBB2/3 associated with epithelial gene signatures, while higher basal FGFR1 and AXL were observed in cells/tumors with mesenchymal gene signatures. CONCLUSIONS: Our phosphoproteomic study identified cell type-adaptive responses to KRASi. Markers and targets associated with ERBB2/3 signaling in epithelial subtype and with FGFR1/AXL signaling in mesenchymal subtype should be considered in patient enrichment schemes with KRASi.

17.
BMC Infect Dis ; 21(1): 208, 2021 Feb 25.
Artigo em Inglês | MEDLINE | ID: mdl-33632141

RESUMO

BACKGROUND: Hand, foot, and mouth disease (HFMD) is an acute infectious disease caused by human enterovirus 71 (EV71), coxsackievirus, or echovirus, which is particularly common in preschool children. Severe HFMD is prone to cause pulmonary edema before progressing to respiratory and circulatory failure; thus hemodynamic monitoring and fluid management are important to the treatment process. METHODS: We did a review of young patients who had been successfully treated in our department for severe HFMD, which had been caused by EV71. A total of 20 patients met the inclusion criteria. Eight cases were monitored by the pulse indicator continuous cardiac output (PiCCO) technique, and fluid management was administered according to its parameters. With regard to the treatment with PiCCO monitoring, patients were divided into two groups: the PiCCO group (8 patients) and the control group (12 patients). The groups were then compared comprehensively to evaluate whether PiCCO monitoring could improve patients' clinical outcomes. RESULTS: After analysis, the findings informed that although PiCCO failed to shorten the length of ICU stay, reduce the days of vasoactive drug usage, or lower the number of cases which required mechanical ventilation, PiCCO did reduce the incidence of fluid overload (p = 0.085) and shorten the days of mechanical ventilation (p = 0.028). After effective treatment, PiCCO monitoring indicated that the cardiac index (CI) increased gradually(p < 0.0001), in contrast to their pulse (P, p < 0.0001), the extra vascular lung water index (EVLWI, p < 0.0001), the global end diastolic volume index (GEDVI, p = 0.0043), and the systemic vascular resistance index (SVRI, p < 0.0001), all of which decreased gradually. CONCLUSION: Our study discovered that PiCCO hemodynamic monitoring in young children with severe HFMD has some potential benefits, such as reducing fluid overload and the duration of mechanical ventilation. However, whether it can ameliorate the severity of the disease, reduce mortality, or prevent multiple organ dysfunction remain to be further investigated.


Assuntos
Hidratação , Doença de Mão, Pé e Boca/fisiopatologia , Doença de Mão, Pé e Boca/terapia , Hemodinâmica/fisiologia , Monitorização Fisiológica/métodos , Débito Cardíaco/fisiologia , Pré-Escolar , Enterovirus Humano A/isolamento & purificação , Feminino , Doença de Mão, Pé e Boca/diagnóstico , Frequência Cardíaca/fisiologia , Humanos , Lactente , Masculino , Edema Pulmonar/diagnóstico , Edema Pulmonar/fisiopatologia , Edema Pulmonar/terapia , Estudos Retrospectivos , Resultado do Tratamento
18.
ACS Nano ; 2021 Feb 19.
Artigo em Inglês | MEDLINE | ID: mdl-33606942

RESUMO

The Berry phase, which reveals the intimate geometrical structure underlying quantum mechanics, plays a central role in the anomalous Hall effect. In this work, we observed a sign change of Berry curvatures at the interface between the ferromagnet SrRuO3 (SRO) layer and the SrIrO3 (SIO) layer with strong spin-orbit coupling. The negative Berry curvature at the interface, induced by the strongly spin-orbit-coupled Ir 5d bands near the Fermi level, makes the SRO/SIO interface different from the SRO layer that has a positive Berry curvature. These opposite Berry curvatures led to two anomalous Hall effect (AHE) channels with opposite signs at the SRO/SIO interface and in the SRO layer, respectively, resulting in a hump-like feature in the Hall resistivity loop. This observation offers a straightforward explanation of the hump-like feature that is usually associated with the chiral magnetic structure or magnetic skyrmions. Hence, this study provides evidence to oppose the widely accepted claim that magnetic skyrmions induce the hump-like feature.

19.
J Orthop Surg Res ; 16(1): 119, 2021 Feb 08.
Artigo em Inglês | MEDLINE | ID: mdl-33557910

RESUMO

BACKGROUND: Although researchers have adopted various methods for the resection and reconstruction of periacetabular tumors, the total incidence rate of complications remains high. Aiming for preserving the acetabulum and reducing the risk of complications, we applied a surgery method using tumor-free autologous femoral head to reconstruct the defective acetabulum after resection of periacetabular tumors followed by performing a conventional total hip arthroplasty (THA). Moreover, we proposed a preliminary classification system for these surgery methods. METHODS: We retrospectively reviewed 6 patients treated with acetabulum reconstruction combined with autologous femoral head following peri-acetabulum resection between April 2010 and May 2018. All patients were diagnosed as periacetabular tumors including chondrosarcoma (n = 5) and chondroblastoma (n = 1). Clinical data such as age, diagnosis, complications, local recurrence or metastasis, and function (Musculoskeletal Tumor Society 1993, MSTS93) were documented. The average time of follow-up was 62.5 months (range, 17 to 106 months). RESULTS: A total of 5 patients survive with average MSTS93 score of 27.8 points (range, 26-30). One patient, suffering from multiple bone metastasis prior treatment, ended up dying. One who had received radiotherapy before surgery had poor incision healing. Further, a classification system was preliminary proposed in 2 patients involving the pubis (type A) and 4 patients involving ischium (type B). CONCLUSIONS: Based on the results, we preliminary proposed a classification system for reconstruction with autologous femoral head after periacetabular low malignant tumors resection. The clinical results suggested that surgery methods involving pubis (type A) and ischium (Type B) are safe and feasible. However, further researches should be conducted to verify our classification system.

20.
Nat Commun ; 12(1): 540, 2021 Jan 22.
Artigo em Inglês | MEDLINE | ID: mdl-33483483

RESUMO

Nonmagnetic Rashba systems with broken inversion symmetry are expected to exhibit nonreciprocal charge transport, a new paradigm of unidirectional magnetoresistance in the absence of ferromagnetic layer. So far, most work on nonreciprocal transport has been solely limited to cryogenic temperatures, which is a major obstacle for exploiting the room-temperature two-terminal devices based on such a nonreciprocal response. Here, we report a nonreciprocal charge transport behavior up to room temperature in semiconductor α-GeTe with coexisting the surface and bulk Rashba states. The combination of the band structure measurements and theoretical calculations strongly suggest that the nonreciprocal response is ascribed to the giant bulk Rashba spin splitting rather than the surface Rashba states. Remarkably, we find that the magnitude of the nonreciprocal response shows an unexpected non-monotonical dependence on temperature. The extended theoretical model based on the second-order spin-orbit coupled magnetotransport enables us to establish the correlation between the nonlinear magnetoresistance and the spin textures in the Rashba system. Our findings offer significant fundamental insight into the physics underlying the nonreciprocity and may pave a route for future rectification devices.

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