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1.
Chem Commun (Camb) ; 2019 Sep 04.
Artigo em Inglês | MEDLINE | ID: mdl-31482876

RESUMO

The construction of a nano-heterojunction photoanode is an attractive strategy for accelerated charge separation. Here, α-Fe2O3 nanorod arrays (Fe2O3 NAs) top-decorated with an MIL-101 layer are achieved via the CVD method for constructing one intimate contact between two layers. The systematical analysis in time-dependent deposition shows that the photoelectric response capability can be modulated by controlling the thickness of the MIL-101 layer as a function of CVD duration. An optimized thickness of 4-6 nm MIL-101 in the Fe2O3/MIL-101 photoanode presents the best PEC performance with the IPCE of 25% and a photocurrent density of 1 mA cm-2 at 1.3 V vs. RHE, about 2.5 times higher than that of pristine Fe2O3 NAs. The exciton lifetime and the electrochemical active surface area of the composited electrode are greatly improved by 14 and 1.3 times respectively compared to that of pristine Fe2O3. The notable advancement can be attributed to the fact that the top-decorated MOF layer can promote charge separation efficiency led by the built-in electric field and form a tight interface between Fe2O3 and MIL-101 with a favorable diffusion length for holes, as well as the fact that it can reduce surface defects and provide more reaction sites.

2.
Thorac Cancer ; 2019 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-31474003

RESUMO

Leiomyosarcoma with osteoclast-like giant cells (LMS-OGC) has seldom been reported clinically. LMS-OGC of the breast is extremely rare according to the literature. Here, we report a case of LMS-OGC leiomyosarcoma with osteoclast-like giant cells of the breast. A 51-year-old female patient presented with a breast mass which was treated surgically and the pathological examination of the tumor indicated LMS-OGC. Microscopically, the tumor was composed of spindle cells arranged in bundles or spokes with giant tumor cells and mitosis. Eosinophilic cytoplasm and morphologically benign osteoclast-like cells were mixed together. Immunohistochemistry examination revealed SMA and desmin were positive with a Ki-67 proliferation index of 40%. However, CK (AE1/AE3), E-cadherin, ER, PR, CD34, S-100 and CD10 were negatively expressed in the tumor tissue. LMS-OGC is a soft tissue malignant tumor which develops extremely rarely in the breast. It should be differentiated and diagnosed according to the history, histological characteristics and immunohistochemical staining.

3.
J Enzyme Inhib Med Chem ; 34(1): 1607-1614, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31474167

RESUMO

Steroids are classes of natural products widely distributed in nature, which have been demonstrated to exhibit broad biological functions, and have also attracted increasing interest from bioorganic and pharmaceutical researches. In order to develop novel chemical entities as potential cytotoxic agents, a series of steroidal isatin conjugations derived from epiandrosterone and androsterone were efficiently prepared and characterized, and all these obtained compounds were screened for their potential cytotoxic activities. The preliminary bioassay indicated that most of the newly synthesized compounds exhibited good cytotoxic activities against human gastric cancer (SGC-7901), melanoma (A875), and hepatocellular liver carcinoma (HepG2) cell lines compared with 5-fluorouracil (5-FU), which might be considered as promising scaffold for further development of potential anticancer agents.

4.
J Phys Chem Lett ; : 5499-5506, 2019 Sep 04.
Artigo em Inglês | MEDLINE | ID: mdl-31475525

RESUMO

Experiments show that excess lead atoms accelerate charge recombination while oxygen passivation can heal the defects and enhance solar cell efficiency. Using ab initio nonadiabatic (NA) molecular dynamics, we demonstrate that an excess lead atom forms a Pb-dimer with a single surface lead atom of CsPbBr3(001) surface and creates a deep hole trap. The electron-hole recombination is accelerated to over 10 ps via fast hole trapping or bypassing the hole trap compared to the pristine CsPbBr3, occurring on tens of picoseconds. Pb-dimer passivated with oxygen molecules forms Pb-O bonds, breaks the Pb-dimer, and removes the trap state, leading to a decrease in the recombination and extending excited-state lifetime to over 100 ps. The deceleration arises mainly due to the reduced NA coupling and short decoherence time. The study advances our understanding of excited-state dynamics of all-inorganic perovskites in the presence of excess lead and oxygen atmosphere.

5.
J Phys Chem A ; 123(34): 7337-7350, 2019 Aug 29.
Artigo em Inglês | MEDLINE | ID: mdl-31373814

RESUMO

The mixed quantum-classical dynamical approaches have been widely used to study nonadiabatic phenomena in photochemistry and photobiology, in which the time evolutions of the electronic and nuclear subsystems are treated based on quantum and classical mechanics, respectively. The key issue is how to deal with coherence and decoherence during the propagation of the two subsystems, which has been the subject of numerous investigations for a few decades. A brief description on Ehrenfest mean-field and surface-hopping (SH) methods is first provided, and then different algorithms for treatment of quantum decoherence are reviewed in the present paper. More attentions were paid to quantum trajectory mean-field (QTMF) method under the picture of quantum measurements, which is able to overcome the overcoherence problem. Furthermore, the combined QTMF and SH algorithm is proposed in the present work, which takes advantages of the QTMF and SH methods. The potential to extend the applicability of the QTMF method was briefly discussed, such as the generalization to other type of nonadiabatic transitions, the combination with multiscale computational models, and possible improvements on its accuracy and efficiency by using machine-learning techniques.

6.
Medicine (Baltimore) ; 98(35): e16998, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31464952

RESUMO

RATIONALE: Syncope caused by head and neck cancer (HNC) is rare. However, syncope caused by tongue cancer (TC) is even rarer. In TC, syncope is caused by tumor-mediated compression of the carotid sinus and stimulation of the glossopharyngeal nerve. PATIENT CONCERNS: In this study, we report the case of a 48-year-old male patient who was diagnosed with advanced TC and bilateral cervical lymph node metastasis. On the third day of admission, the patient experienced recurrent syncope with hypotension and bradycardia. DIAGNOSES: The patient was diagnosed with a well-differentiated squamous cell carcinoma of the tongue along with massive cervical lymph node metastasis and carotid sinus syndrome. INTERVENTIONS: Initially, symptomatic treatment of syncope boosted the blood pressure and increased the heart rate. Thereafter, a temporary pacemaker was implanted. Finally, chemotherapy was used to control the tumor and relieve syncope. OUTCOMES: After chemotherapy, the tongue ulcers and cervical lymph node reduced in size; syncope did not recur. LESSONS: This case shows that chemotherapy may be a valid treatment option in patients with cancer-related syncope; however, the choice of chemotherapeutic drugs is critical. Intensive care provides life support to patients and creates opportunities for further treatment.

7.
Acta Pharmacol Sin ; 2019 Aug 20.
Artigo em Inglês | MEDLINE | ID: mdl-31431734

RESUMO

Long non-coding RNAs (lncRNAs) have been identified as essential mediators in neurological dysfunction. Our previous study shows that berberine (BBR) hampers the nuclear-to-cytosolic translocation of high-mobility group box 1 (HMGB1) in the process of poststroke inflammation. In this study, we explored the role of lncRNA metastasis-associated lung adenocarcinoma transcript 1 (Malat1) in the process of BBR-induced inhibition of HMGB1 in ischemic brain. Before the 60-min MCAO surgery, the mice were pretreated with BBR (50 mg· kg-1 per day, ig) for 14 days or ICV injected with specific lentiviral vector or shRNA. We showed that MCAO caused marked increase in the expression Malat1 and HMGB1 in the ipsilateral cortex, which was significantly attenuated by pretreatment with BBR. Knockdown of Malat1 attenuated the inflammatory injury after brain ischemia, whereas overexpression of Malat1 exacerbated ischemic brain inflammation. Overexpression of Malat1 also reversed BBR-induced reduction of HMGB1 and proinflammatory cytokines. The above results suggested a potential correlation between Malat1 and stroke inflammation. Based on informatics analysis we predicted that HMGB1 was a direct downstream target of miR-181c-5p, whereas Malat1 acted as a competitive endogenous RNA (ceRNA) for miR-181c-5p targeted the 3'-UTR of HMGB1 to promote inflammation after ischemic stroke. Knockdown of Malat1 significantly decreased HMGB1 level, which could be abrogated by transfection with miR-181c-5p inhibitors. Taken together, our results demonstrate for the first time that Malat1/miR-181c-5p/HMGB1 axis may be a key pathway of BBR-induced antiinflammation effects in stroke, and they may provide a novel avenue for targeted therapy.

8.
Front Immunol ; 10: 1725, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31404168

RESUMO

Tumor necrosis factor alpha (TNF-α) plays a critical role in the control of cryptococcal infection, and its insufficiency promotes cryptococcal persistence. To explore the therapeutic potential of TNF-α supplementation as a booster of host anti-cryptococcal responses, we engineered a C. neoformans strain expressing murine TNF-α. Using a murine model of pulmonary cryptococcosis, we demonstrated that TNF-α-producing C. neoformans strain enhances protective elements of host response including preferential T-cell accumulation and improved Th1/Th2 cytokine balance, diminished pulmonary eosinophilia and alternative activation of lung macrophages at the adaptive phase of infection compared to wild type strain-infected mice. Furthermore, TNF-α expression by C. neoformans enhanced the fungicidal activity of macrophages in vitro. Finally, mice infected with the TNF-α-producing C. neoformans strain showed improved fungal control and considerably prolonged survival compared to wild type strain-infected mice, but could not induce sterilizing immunity. Taken together, our results support that TNF-α expression by an engineered C. neoformans strain while insufficient to drive complete immune protection, strongly enhanced protective responses during primary cryptococcal infection.

9.
Org Biomol Chem ; 2019 Aug 12.
Artigo em Inglês | MEDLINE | ID: mdl-31402366

RESUMO

Two novel sorbicillinoid adducts containing bicyclo[2.2.2]octane and tetrahydrofuran moieties, named sorbicillfurans A and B (1 and 2), were isolated from the static culture of the marine-derived fungus Penicillium citrinum SCSIO41402. Their structures including absolute configurations were determined by spectroscopic and calculated ECD analyses. Sorbicillfurans A and B (1 and 2) are the first examples of sorbicillinoids possessing a tetrahydrofuran unit. In the proposed biosynthetic pathway, sorbicillfuran B (2), harboring a rare and complex polycyclic framework, is probably formed by two Diels-Alder reactions. Both isolates were evaluated for the cytotoxicity against six human cancer cell lines, only sorbicillfuran B (2) showed weak cytotoxicity against HL-60 cells with an IC50 value of 9.6 µM.

10.
J Phys Chem A ; 2019 Aug 28.
Artigo em Inglês | MEDLINE | ID: mdl-31419385

RESUMO

Understanding of photoinduced interfacial carrier dynamics in organic-transition metal dichalcogenides heterostructures is very important for the enhancement of their potential photoelectronic conversion efficiencies. In this work we have used density functional theory (DFT) calculations and DFT-based fewest-switches surface-hopping dynamics simulations to explore the photoinduced hole transfer and subsequent nonadiabatic electron-hole recombination dynamics taking place at the interface of pentacene and MoS2 in pentacene@MoS2. Upon photoexcitation the electronic transition mainly occurs on the MoS2 monolayer, which corresponds to moving an electron to the MoS2 conduction band. As a result, a hole is left in the valence band. This hole state is energetically lower than certain occupied states of the pentacene molecule; thus, the interfacial hole transfer from MoS2 to pentacene is favorable in energy. In terms of nonadiabatic dynamics simulations, the hole transfer time to the HOMO-1 state of the pentacene is estimated to be about 600 fs; however, the following hole relaxation process from HOMO-1 to HOMO takes much longer time of ca. 15 ps due to the large energy gap between HOMO-1 and HOMO. Moreover, our results also show that the subsequent radiationless recombination process between the hole transferred to the pentacene molecule and the remaining electron on the MoS2 CBM needs about 10.2 ns. The computational results shed important mechanistic insights on the interfacial carrier dynamics of mixed-dimensional pentacene@MoS2. These insights could help to design excellent interfaces for organic-TMDs heterostructures.

11.
Pestic Biochem Physiol ; 159: 91-97, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31400790

RESUMO

The organophosphorus pesticide, triazophos (TAP) was banned to use in agriculture in several countries due to its high toxicity. However, TAP was still widely used and frequently detected in foods. Recently, many studies reported the endocrine-disrupting effect of pesticides, especially the hypothalamic-pituitary-thyroid and hypothalamic-pituitary-gonadal axis. In this study, adult male Wistar rats were exposed to TAP at the dose of 0.164 and 1.64 mg/kg bodyweight (~1/500th and 1/50th of LD50) for 24 weeks and serum contents of hormones were measured. TAP exposure significantly reduced serum contents of adrenocorticotropic hormone, corticosterone and epinephrine in rats (p < .05), leading to the delay in glucose homeostasis during the insulin tolerance test and decrease in serum contents of total cholesterol, triglyceride and low density lipoprotein. Molecular docking results suggested TAP may be an antagonist of glucocorticoid receptor which decreased significantly in the liver of rats, resulting in the decreased expression of 11ß-hydroxysteroid dehydrogenase 1 and PEPCK1. This study revealed that TAP is a potential endocrine disruptor, especially in the hypothalamus-pituitary-adrenal system and may disturb the metabolism by affecting glucocorticoid receptor. This study provided new evidence about the toxicity of TAP and it was necessary to strictly control the usage of TAP in food.


Assuntos
Hipotálamo/efeitos dos fármacos , Organotiofosfatos/farmacologia , Praguicidas/farmacologia , Sistema Hipófise-Suprarrenal/efeitos dos fármacos , Triazóis/farmacologia , 11-beta-Hidroxiesteroide Desidrogenases/metabolismo , Animais , Colesterol/metabolismo , Lipoproteínas LDL/metabolismo , Masculino , Simulação de Acoplamento Molecular , Ratos , Ratos Wistar , Triglicerídeos/metabolismo
12.
ACS Nano ; 2019 Aug 27.
Artigo em Inglês | MEDLINE | ID: mdl-31430428

RESUMO

An in situ forming hydrogel has emerged as a promising wound dressing recently. As physically cross-linked hydrogels are normally unstable, most in situ forming hydrogels are chemically cross-linked. However, big concerns have remained regarding the slow gelation and the potential toxicity of residual functional groups from cross-linkers or the polymer matrix. Herein, we report a sprayable in situ forming hydrogel composed of poly(N-isopropylacrylamide166-co-n-butyl acrylate9)-poly(ethylene glycol)-poly(N-isopropylacrylamide166-co-n-butyl acrylate9) copolymer (P(NIPAM166-co-nBA9)-PEG-P(NIPAM166-co-nBA9), denoted as PEP) and silver-nanoparticles-decorated reduced graphene oxide nanosheets (Ag@rGO, denoted as AG) in response to skin temperature. This thermoresponsive hydrogel exhibits intriguing sol-gel irreversibility at low temperatures for the stable dressing of a wound, which is attributed to the inorganic/polymeric dual network and abundant coordination interactions between Ag@rGO nanosheets and PNIPAM. The biocompatibility and antibacterial ability against methicillin-resistant Staphylococcus aureus (MRSA) of this PEP-AG hydrogel wound dressing are confirmed in vitro and in vivo, which could transparently promote the healing of a MRSA-infected skin defect.

13.
Artigo em Inglês | MEDLINE | ID: mdl-31465874

RESUMO

A feeding experiment was conducted to determine the effects of fish oil replaced by olive oil (OO) on growth performance, serum biochemical, antioxidant capacity and inflammatory response in large yellow croaker (Larimichthys crocea). Four iso-nitrogenous and iso-lipidic diets were formulated by replacing fish oil (FO) with 0% (the control group), 33.3%, 66.7% and 100% OO. Fish fed the diet with 100% OO had the lowest growth performance among dietary treatments. However, there were no significant differences in SGR and FI among fish fed diets with 0% (the control group), 33.3% and 66.7% OO (P > 0.05). As to somatic index, HSI was significantly increased in fish fed the diet with 100% OO than the control group (P < 0.05). Furthermore, the lipid content of the liver in fish fed the diet with 100% OO was significantly higher than the control group (P < 0.05). Fish fed the diet with 100% OO had the highest content of C18:1n-9 among dietary treatments. Serum total triglyceride (TG), low-density lipoprotein-cholesterol (LDL-C) levels and activity of serum alanine transaminase (ALT) were significantly increased in fish fed the diet with 100% OO compared with the control group (P < 0.05). Meanwhile, dietary OO decreased the activity of superoxide dismutase (SOD) and the total antioxidant capacity (T-AOC) in fish fed diets with increasing dietary OO levels. However, the content of malondialdehyde (MDA) was significantly increased in fish fed the diet with 100% OO compared with the control group (P < 0.05). The expression of pro-inflammatory genes, COX-2, IL-1ß and TNFα, were significantly increased in the liver of fish fed the diet with 100% OO compared with the control group (P < 0.05), which was probably due to the activation of p38 mitogen-activated protein kinase (p38 MAPK) pathways and Jun N-terminal kinase (JNK) as the increased protein ratio of p-p38 MAPK to p38 MAPK and p-JNK to JNK. These results suggested that high level of dietary OO decreased the growth performance and antioxidant capacity but induced inflammation via the activation of p38 MAPK and JNK pathways in large yellow croaker.

14.
J Therm Biol ; 84: 375-383, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31466777

RESUMO

Bile acids (BAs) are critical for cholesterol homeostasis and new roles in metabolism and endocrinology have been demonstrated recently. It remains unknown whether BA metabolism can be affected by heat stress (HS). The objective of this study was to describe the shifts in serum, hepatic and intestinal BA profiles induced by chronic HS. Twenty-seven Large White pigs weighing 40.8 ±â€¯2.7 kg were assigned to one of the three treatments: a control group (CON, 23 °C), a HS group (33 °C), or a pair-fed group (PF, 23 °C and fed the same amount as HS group) for 21 d. The concentrations of taurine-conjugated BAs (TUDCA and THDCA in serum and TCDCA, TUDCA, THDCA and THCA in liver) were decreased in HS and PF pigs. However, in HS pigs, a reduction in taurine-conjugated BAs (TCBA) correlated with decreased liver genes expression of BA synthesis, conjugation and uptake transport. BA regulated-genes (FXR, TGR5 and FGFR4) in HS pigs and TGR5, FGFR4 and KLß in PF pigs were down-regulated in liver. In ileum, total BAs and glycoursodeoxycholic acid concentrations were higher in HS pigs than other groups and PF group, respectively (P < 0.05). TCBA (P = 0.01) and tauroursodeoxycholic acid (P < 0.01) were decreased in PF group. BA transporters (OSTα and MRP3) were up-regulated in HS pigs compared with CON and PF pigs, respectively (P < 0.01). In cecum, ursodeoxycholic acid was higher in HS (P = 0.02) group than CON group. The expression of apical sodium-coupled bile acid transporter (P = 0.04) was lower in HS pigs than CON pigs, while OSTß (P < 0.01) was greater in HS group than PF group. These results suggest that chronic HS suppressed liver activity of synthesis and uptake of TCBA, at least in part, which was independent of reduced feed intake.

15.
Zhongguo Yi Liao Qi Xie Za Zhi ; 43(4): 263-265, 2019 Jul 30.
Artigo em Chinês | MEDLINE | ID: mdl-31460717

RESUMO

This study was to design a chronic obstructive pulmonary disease (COPD) screening equipment, based on the dual-differential pressure throttling technique. The technique combined a wide range, but low-resolution ratio sensor and a narrow range, but high-resolution ratio one. It can accurately detect the indexes of forced vital capacity (FVC), forced expiratory volume in one second (FEV1), one second rate(FEV1/FVC (%)), and achieve them in a low-cost way. The new designed machine will be compared with a British machine, named ML-3500. The correlations of FVC and FEV1 between new machine and ML-3500 were 0.998 and 0.999, respectively. The P values of paired t test of these two indexes were over 0.05. Bland-Altman analysis of FVC, FEV1 and FEV1/FVC (%) showed that more than 90% of the scatter points of the three parameters fell within the consistency interval. This machine can be used to accurately screen COPD and its low-cost would be advantage to promote in large population.

16.
Food Chem Toxicol ; 133: 110759, 2019 Aug 14.
Artigo em Inglês | MEDLINE | ID: mdl-31421215

RESUMO

Triazophos (TAP) was a widely used organophosphorus insecticide in developing countries. TAP could produce specific metabolites triazophos-oxon (TAPO) and 1-phenyl-3-hydroxy-1,2,4-triazole (PHT) and non-specific metabolites diethylthiophosphate (DETP) and diethylphosphate (DEP). The objective of this study involved computational approaches to discover potential mechanisms of molecular interaction of TAP and its major metabolites with endocrine hormone-related proteins using molecular docking in silico. We found that TAP, TAPO and DEP showed high binding affinity with more proteins and enzymes than PHT and DETP. TAP might interfere with the endocrine function of the adrenal gland, and TAP might also bind strongly with glucocorticoid receptors and thyroid hormone receptors. TAPO might disrupt the normal binding of androgen receptor, estrogen receptor, progesterone receptor and adrenergic receptor to their natural hormone ligands. DEP might affect biosynthesis of steroid hormones and thyroid hormones. Meanwhile, DEP might disrupt the binding and transport of thyroid hormones in the blood and the normal binding of thyroid hormones to their receptors. These results suggested that TAP and DEP might have endocrine disrupting activities and were potential endocrine disrupting chemicals. Our results provided further reference for the comprehensive evaluation of toxicity of organophosphorus chemicals and their metabolites.

17.
Artigo em Inglês | MEDLINE | ID: mdl-31380736

RESUMO

A Gram-negative bacterium, namely strain ANRC-JHZ47T, was isolated from a seawater sample collected at Biological Bay, Fildes Peninsula, Antarctica. Cells of strain ANRC-JHZ47T were rod-shaped and motile by a single polar flagellum. Strain ANRC-JHZ47T was aerobic, oxidase-negative, and catalase-positive. The strain grew at 4-37 °C (optimum, 25 °C), pH at 3.5-10.0 (optimum, pH 5.5) and in NaCl at 1-7.0 % (w/v; optimum, 2-3 %). Strain ANRC-JHZ47T used Q-8 as the predominant respiratory quinone. Its predominant fatty acids were C16 : 0 (21.9 %), C12 : 0 (12.6 %), C19 : 0cyclo ω8c (12.4 %), summed feature 3 (C16 : 1ω7c and/or C16 : 1ω6c; 13.1 %), C10 : 0 3-OH (11.3 %) and summed feature 8 (C18 : 1ω7c and/or C18 : 1ω6c; 6.0 %). Its major polar lipids were phosphatidylglycerol, phosphatidylethanolamine, diphosphatidylglycerol, one unidentified aminolipid and five unknown polar lipids. The DNA G+C content was 42.6 mol%. Strain ANRC-JHZ47T showed the highest 16S rRNA gene sequence similarity to Marinomonas arenicola KMM 3893T (97.9 %), followed by Marinomonas primoryensis KMM 3633T (97.6 %), Marinomonas profundimaris D104T (97.2 %) and Marinomonas pollencensis IVIA-Po-185T (97.0 %). Furthermore, the average nucleotide identity values between strain ANRC-JHZ47T and M. arenicola KMM 3893T, M. primoryensis KMM 3633T and M. profundimaris D104T were 79.8, 74.0, and 74.1 %, respectively. The in silico DNA-DNA hybridization values between them were 22.5±2.5, 20.4±2.3 and 19.9±2.3 %, respectively. Based on the results of phenotypic and phylogenetic analyses, strain ANRC-JHZ47T is considered to represent a novel species of the genus Marinomonas, for which the name Marinomonas flavescens sp. nov. is proposed. The type strain is ANRC-JHZ47T (=MCCC 1K03604T=KCTC 72113T).

18.
Sensors (Basel) ; 19(13)2019 Jul 07.
Artigo em Inglês | MEDLINE | ID: mdl-31284673

RESUMO

When applying an optical current transformer (OCT) to direct current measurement, output signals exhibit a low signal-to-noise ratio and signal-to-noise band overlap. Sinusoidal wave modulation is used to solve this problem. A double correlation detection algorithm is used to extract the direct current (DC) signal, remove white noise and improve the signal-to-noise ratio. Our sensing unit uses a terbium gallium garnet crystal in order to increase the output signal-to-noise ratio and measurement sensitivity. Measurement errors of single correlation and double correlation detection algorithms are compared, and experimental results showed that this measurement method can control measurement error to about 0.3%, thus verifying its feasibility.

19.
PLoS One ; 14(7): e0219406, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31283774

RESUMO

Postoperative shed autologous blood reinfusion techniques have been used for decades in total knee arthroplasty (TKA), but the effectiveness of this procedure is still a matter of debate. This multicenter retrospective study investigated the medical records of patients who underwent unilateral and bilateral TKA from January 1, 2015 to December 31, 2017 in three hospitals. According to whether postoperative shed autologous blood reinfusion was used, the patients were divided into the control group and the shed autologous blood reinfusion group. The volume of perioperative infusion of red blood cells and plasma, the blood transfusion-related costs, and the postoperative hospital stay were compared between the two groups of patients. A total of 200 unilateral and 74 bilateral TKA were included after successful matching. Among the patients who underwent unilateral TKA, the control group and the shed autologous blood reinfusion group had 95 and 91 patients, respectively, who received allogeneic blood infusion (P = 0.268). There was no significant difference in the number of units of allogeneic red blood cells infused (P = 0.154), while the transfusion-related cost was increased (P<0.001). The same phenomena were observed over the patients underwent bilateral TKA. Shed autologous blood reinfusion does not reduce the need for infusing allogeneic red blood cells. In addition, the procedure increases patient expense and may also lead to an extended postoperative hospital stay.

20.
Waste Manag ; 95: 289-297, 2019 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-31351614

RESUMO

The effects of iron oxide nanoparticles (IONPs, including Fe2O3 NPs and Fe3O4 NPs) on composting were investigated through evaluating their influences on organic matter (OM) degradation, dehydrogenase (DHA) and urease (UA) activities, and quality of the final compost product. Results showed that composting amended with Fe2O3 NPs was more effective to facilitate OM degradation. At the end of composting, the total OM loss in T-C, T-Fe2O3 NPs and T-Fe3O4 NPs was 66.19%, 75.53% and 61.31%, respectively. DHA and UA were also improved on the whole by the amendment of IONPs, especially Fe2O3 NPs. Although relationships between enzyme activities and environmental variables were changed by different treatments, temperature was the most influential to variations of both DHA and UA in all treatments, which independently explained 75.1%, 34.7% and 38.4% of variations in the two enzyme activities in T-C, T-Fe2O3 NPs and T-Fe3O4 NPs, respectively. Compared with DHA, UA was more closely related to the environmental parameters. The germination index in T-C, T-Fe2O3 NPs and T-Fe3O4 NPs was 134.49%, 153.64% and 146.76%, and the average shoot length was 3.16, 3.87 and 3.45 cm, respectively, indicating that amendment of IONPs, especially Fe2O3 NPs, could promote seed germination and seedling growth. Therefore, composting amended with IONPs was a feasible and promising method to improve composting performance, enzyme activities as well as quality of the final compost product.

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