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1.
Mol Cancer ; 21(1): 4, 2022 01 03.
Artigo em Inglês | MEDLINE | ID: mdl-34980131

RESUMO

BACKGROUND: Camrelizumab plus chemotherapy significantly prolonged progression-free survival (PFS) and overall survival (OS) compared to chemotherapy alone as first-line treatment in advanced lung squamous cell carcinoma (LUSC) in the phase III trial (CameL-sq), which has become an option of standard-of-cares for Chinese patients with advanced LUSC. However, the predictive biomarkers remain unknown. METHODS: Tumor tissue samples at baseline, and peripheral blood samples at baseline (pretreatment) and after two cycles of treatment (on-treatment) were prospectively collected from 270 LUSC patients from the CameL-sq study. Blood tumor mutation burden (bTMB) and its dynamics were analyzed to explore their predictive values. RESULTS: Pretreatment bTMB was not associated with objective response, PFS and OS in camrelizumab or placebo plus chemotherapy groups. Low on-treatment bTMB was associated with significantly better objective response (73.8% vs 27.8%, P < 0.001), PFS (median, 9.1 vs 4.1 months; P < 0.001) and OS (median, not reached vs 8.0 months; P < 0.001) in camrelizumab plus chemotherapy group whereas it did not correlate with objective response and PFS in chemotherapy alone group. Importantly, on-treatment bTMB level could discriminate patients of initially radiological stable disease who would long-term benefit from camrelizumab plus chemotherapy (low vs high, median OS, 18.2 vs 7.8 months; P = 0.001). Combing on-treatment bTMB and its dynamics improved the ability for predicting the efficacy of camrelizumab plus chemotherapy. CONCLUSION: On-treatment bTMB together with its dynamics could serve as a predictive biomarker for camrelizumab plus chemotherapy in patients with advanced LUSC. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT03668496.

2.
Nanotechnology ; 33(13)2022 Jan 07.
Artigo em Inglês | MEDLINE | ID: mdl-34915460

RESUMO

Random nanowire networks (NWNs) are regarded as promising memristive materials for applications in information storage, selectors, and neuromorphic computing. The further insight to understand their resistive switching properties and conduction mechanisms is crucial to realize the full potential of random NWNs. Here, a novel planar memristive device based on necklace-like structure Ag@TiO2NWN is reported, in which a strategy only using water to tailor the TiO2shell on Ag core for necklace-like core-shell structure is developed to achieve uniform topology connectivity. With analyzing the influence of compliance current on resistive switching characteristics and further tracing evolution trends of resistance state during the repetitive switching cycles, two distinctive evolution trends of low resistance state failure and high resistance state failure are revealed, which bear resemblance to memory loss and consolidation in biological systems. The underlying conduction mechanisms are related to the modulation of the Ag accumulation dynamics inside the filaments at cross-point junctions within conductive paths of NWNs. An optimizing principle is then proposed to design reproducible and reliable threshold switching devices by tuning the NWN density and electrical stimulation. The optimized threshold switching devices have a high ON/OFF ratio of ∼107with threshold voltage as low as 0.35 V. This work will provide insights into engineering random NWNs for diverse functions by modulating external excitation and optimizing NWN parameters to satisfy specific applications, transforming from neuromorphic systems to threshold switching devices as selectors.

3.
Food Chem ; 372: 131142, 2022 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-34600193

RESUMO

To determine the glutathione (GSH) content in vegetables, an "on-off-on" fluorescence probe was developed by a synthesis of nitrogen and sulfur co-doped carbon dots (N,S-CDs) using the microwave pyrolysis considering citric acid and L-cysteine as precursors. The fluorescence of N,S-CDs was quenched by adding Cu2+ at a concentration of 20-200 µmol/L due to the inner filter effect. The quenched fluorescence of N,S-CDs@Cu2+ system was recovered by adding the GSH at a concentration of 10-150 µmol/L due to the sulfhydryl-metal compound mechanism. By observing the GSH concentrations measured by our N,S-CDs@Cu2+ system vs. a traditional fluorescent chelating method, the two measurements provided the GSH data with a good consistence by showing the RSD range of 1.86%-2.27%. This indicates the validation and novelty of our N,S-CDs@Cu2+ system as being a powerful fluorescent probe for effectively and efficiently determining the GSH in vegetables.


Assuntos
Glutationa , Pontos Quânticos , Carbono , Corantes Fluorescentes , Nitrogênio , Espectrometria de Fluorescência , Enxofre , Verduras
4.
Food Chem ; 370: 130976, 2022 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-34788945

RESUMO

To use hydrocolloids for improving the breadmaking performance of whole wheat flour dough, relationships between hydrocolloid addition and dough thermomechanical, viscoelastic and microstructural properties were investigated. The responses of dough thermomechanical and viscoelastic properties to hydrocolloid addition depended on the hydrocolloid type. A power-law gel model fitted well to the linear and non-linear viscoelastic parameters, i.e., G'(ω), G''(ω) and J(t), of doughs. The model parameters gel strength (S) and exponent (n) were well indicative of hydrocolloid-induced changes in dough strength and relaxation behavior. The torque-scale mixolab parameters C2, C3 and C5, showed a good linear relationship with hydrocolloid addition. These parameters were also well correlated with S and n. Hydrocolloids played a crucial role in the modification for dough microstructure by forming a more continuous gluten network and better connection between starch granules and protein matrix.


Assuntos
Pão , Farinha , Coloides , Glutens , Triticum
5.
Food Chem ; 369: 130877, 2022 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-34455327

RESUMO

This study focused on exploring the structural variations of starch co-fermented by Lactobacillus plantarum LB-1 and yeast (Saccharomyces cerevisiae), and the relationship between fermented starch structure and dough characteristics. Co-fermentation resulted in the increased short chain content and crystallinity (32.07%) of starch with lower molecular weight. A higher content of fingerprint A-chains of amylopectin and fingerprint B-chains of α, ß-limited dextrin in the co-fermented starch endowed dough with excellent anti-retrogradation ability. Moreover, the co-fermented starch with higher swelling power (9.44 g/g) and solubility (20.40%) had a rough and irregular structure and many gaps in the appearance, which were conducive to binding water, thus promoting high dough elasticity and strength. These results extended the knowledge of starch structure-property relationship under the microbial activities, which may be beneficial to promote better flour products.


Assuntos
Lactobacillus plantarum , Amido , Amilopectina , Fermentação , Farinha , Saccharomyces cerevisiae
6.
J Colloid Interface Sci ; 606(Pt 2): 1745-1757, 2022 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-34500172

RESUMO

Herein, the optional and controllable growth of Bi2S3 onto NH2-MIL-125 via covalent conjunction strategy was reported. The experimental results demonstrate that the obtained heterojunction exhibits boosting photocatalytic reduction CO2 and organic dye degradation. The 18-Bi2S3@NH2-MIL-125-SH displays the highest yield of 12.46 µmol g-1h-1 of CO, >13 times that of pure NH2-MIL-125. Meanwhile, the reaction kinetic of 18-Bi2S3@NH2-MIL-125-SH in the degradation of methylene blue is uppermost, which is 160 times than that of the commercial P25. The enhancement of photocatalytic performance could be ascribed to the covalent coordination-driven intimate interfacial interaction in n-scheme heterojunction. Meanwhile, the plausible mechanism was also investigated by UV-vis diffuse reflectance (UV-vis), photoluminescence (PL), electrochemical photocurrent, electron spin resonance (ESR) and electrochemical impedance spectroscopy (EIS).


Assuntos
Dióxido de Carbono , Titânio , Catálise , Luz , Dietilamida do Ácido Lisérgico/análogos & derivados
7.
Food Chem ; : 131666, 2021 Nov 25.
Artigo em Inglês | MEDLINE | ID: mdl-34848090

RESUMO

An optical detection platform based on laser induced spectroscopy and double integrating spheres techniques was developed to obtain absorption (µa), reduced scattering coefficients (µ's) and fluorescence intensity of oil. The validation experiment carried on liquid phantoms showed that the developed system could achieve high linearity, and the results of spectra analysis indicated that the fluorescence intensity has a significant negative correlation with both µa and µ's. A total of 1620 oils with six categories were detected. The reason for the difference of fluorescence and µa spectra was analyzed by comparing the measured chlorophyll, polyphenol and α-tocopherol contents. Linear discriminant analysis combined with principal component analysis based on fluorescence and µa spectra was employed, to calibrate the AFB1 classification models. The discrimination results manifested that by integrating µa with fluorescence signal, the correct classification rate could be improved by more than 10%, and the false negative rate was greatly reduced.

8.
J Cancer Res Ther ; 17(5): 1141-1156, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34850761

RESUMO

The Expert Consensus reviews current literatures and provides clinical practice guidelines for thermal ablation of pulmonary subsolid nodules or ground-glass nodule (GGN). The main contents include the following: (1) clinical evaluation of GGN; (2) procedures, indications, contraindications, outcomes evaluation, and related complications of thermal ablation for GGN; and (3) future development directions.

9.
Comput Intell Neurosci ; 2021: 8548482, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34868298

RESUMO

How to solve the numerical solution of nonlinear partial differential equations efficiently and conveniently has always been a difficult and meaningful problem. In this paper, the data-driven quasiperiodic wave, periodic wave, and soliton solutions of the KdV-mKdV equation are simulated by the multilayer physics-informed neural networks (PINNs) and compared with the exact solution obtained by the generalized Jacobi elliptic function method. Firstly, the different types of solitary wave solutions are used as initial data to train the PINNs. At the same time, the different PINNs are applied to learn the same initial data by selecting the different numbers of initial points sampled, residual collocation points sampled, network layers, and neurons per hidden layer, respectively. The result shows that the PINNs well reconstruct the dynamical behaviors of the quasiperiodic wave, periodic wave, and soliton solutions for the KdV-mKdV equation, which gives a good way to simulate the solutions of nonlinear partial differential equations via one deep learning method.

10.
Biotechnol Biofuels ; 14(1): 242, 2021 Dec 17.
Artigo em Inglês | MEDLINE | ID: mdl-34920748

RESUMO

BACKGROUND: Pleurotus ostreatus is an edible mushroom popularly cultivated worldwide. Distilled grain waste (DGW) is a potential substrate for P. ostreatus cultivation. However, components in DGW restrict P. ostreatus mycelial growth. Therefore, a cost-effective approach to facilitate rapid P. ostreatus colonization on DGW substrate will benefit P. ostreatus cultivation and DGW recycling. RESULTS: Five dominant indigenous bacteria, Sphingobacterium sp. X1, Ureibacillus sp. X2, Pseudoxanthomonas sp. X3, Geobacillus sp. X4, and Aeribacillus sp. X5, were isolated from DGW and selected to develop a consortium-based microbial agent to compost DGW for P. ostreatus cultivation. Microbial agent inoculation led to faster carbohydrate metabolism, a higher temperature (73.2 vs. 71.2 °C), a longer thermophilic phase (5 vs. 3 days), and significant dynamic changes in microbial community composition and diversity in composts than those of the controls. Metagenomic analysis showed the enhanced microbial metabolisms, such as xenobiotic biodegradation and metabolism and terpenoid and polyketide metabolism, during the mesophilic phase after microbial agent inoculation, which may facilitate the fungal colonization on the substrate. In accordance with the bioinformatic analysis, a faster colonization of P. ostreatus was observed in the composts with microbial inoculation than in control after composting for 48 h, as indicated from substantially higher fungal ergosterol content, faster lignocellulose degradation, and higher lignocellulase activities in the former than in the latter. The final mushroom yield shared no significant difference between composts with microbial inoculation and control, with 0.67 ± 0.05 and 0.60 ± 0.04 kg fresh mushroom/kg DGW, respectively (p > 0.05). CONCLUSION: The consortium-based microbial agent comprised indigenous microorganisms showing application potential in composting DGW for providing substrate for P. ostreatus cultivation and will provide an alternative to facilitate DGW recycling.

11.
Chem Sci ; 12(45): 15151-15156, 2021 Nov 24.
Artigo em Inglês | MEDLINE | ID: mdl-34909157

RESUMO

Molecules with luminescence have been extensively investigated, but the luminescence of a stable molecule with a triplet ground state has not been observed. Synthesis of boron-containing radicals has attracted lots of interest because of their unique electronic structures and potential applications in organic semiconductors. Though some boron-based diradicals have been reported, neutral boron-containing diradicals with triplet ground states are rare. Herein two borocyclic diradicals with different substituents (3 and 4) have been isolated. Their electronic structures were investigated by EPR and UV spectroscopy, and SQUID magnetometry, in conjunction with DFT calculations. Both experiment and calculation suggest that 3 is an open shell singlet diradical while 4 is a triplet ground state diradical with a large singlet-triplet gap (0.25 kcal mol-1). Both diradicals show multi fluorescence peaks (3: 414, 431, and 470 nm; 4: 420, 433, and 495 nm). 3 displays multiple redox steps and is a potential material towards the design of high-density memory devices. 4 represents the first example of a neutral triplet boron-containing diradical with a strong ferromagnetic interaction, and also is the first stable triplet diradical emitter.

12.
Front Oncol ; 11: 789915, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34956906

RESUMO

Purpose: Immunotherapy for gastrointestinal stromal tumors (GISTs) remains a clinical challenge. The present study aimed to explore the clinical and prognostic significance of immune cell infiltration and PD-L1 expression in GISTs. Methods: A total of 507 clinical tissue specimens of primary GISTs were collected for immunohistochemical analysis of immune cell infiltration and PD-L1 expression. Influencing factors of survival were evaluated by Kaplan-Meier analysis. Univariate and multivariate analyses were performed using the Cox regression model. Results: There were significant differences in sex, tumor location, size, mitotic index, NIH risk grade, and cell morphology between different gene mutation types of GISTs. Immune cell infiltration in GISTs mainly involved macrophages and T cells. PD-1 was expressed in 48.5% of the tissue specimens, and PD-L1 expression was detected in 46.0% of the samples. PD-L1 expression was negatively correlated with the tumor size and mitotic index but positively correlated with the number of CD8+ T cells. There were significant differences in the number of CD8+ T cells between different gene mutation types. Wild type-mutant GISTs were enriched with CD8+ T cells as compared with KIT- and PDGFRA-mutant GISTs. The number of CD8+ T cells was higher in non-gastric GISTs. PD-L1 and CD8+ T cells were independent predictors for better relapse-free survival of GISTs. Conclusions: PD-L1 expression is a predictive biomarker for better prognosis of GISTs. Non-gastric GIST patients with wild-type mutations may be the beneficiaries of PD-1/PD-L1 inhibitors.

13.
J Thorac Oncol ; 2021 Dec 16.
Artigo em Inglês | MEDLINE | ID: mdl-34923163

RESUMO

INTRODUCTION: Camrelizumab, a humanized IgG4-κ monoclonal antibody against PD-1, has demonstrated anti-tumor activity and tolerability across various tumors, including lung cancers. We conducted this double-blind, randomized phase 3 trial to investigate the efficacy and safety of camrelizumab or placebo plus chemotherapy as first-line treatment for patients with advanced squamous non-small-cell lung cancer (NSCLC). The predictive value of circulating tumor DNA (ctDNA) dynamics was also analyzed. METHODS: CameL-sq, a double-blind, randomized phase 3 trial (NCT03668496), was conducted in 53 centers in China. 389 patients with stage IIIB-IV squamous NSCLC were randomized (1:1) to receive 4-6 cycles of carboplatin plus paclitaxel with camrelizumab or placebo (q3w), followed by maintenance therapy with camrelizumab or placebo. Peripheral blood ctDNA samples were collected at the baseline and the time after two cycles of treatment. RESULTS: Of 389 eligible patients, 193 patients allocated camrelizumab plus chemotherapy and 196 patients allocated placebo plus chemotherapy were included in the efficacy and safety analysis. The results showed significantly prolonged progression-free survival (PFS, median, 8·5 vs 4.9 months; p<0.0001) and overall survival (OS, median, not reached vs 14.5 months; p<0.0001) with camrelizumab-chemotherapy versus placebo-chemotherapy. No unexpected treatment/immune-related adverse events were observed in both two groups. Biomarker analysis revealed that ctDNA clearance after two cycles treatment was independently associated with dramatically longer PFS (p<0.0001) and OS (p<0.0001) in camrelizumab plus chemotherapy group. CONCLUSIONS: Our findings support camrelizumab plus chemotherapy as a first-line treatment option in advanced squamous NSCLC. On-treatment ctDNA dynamics showed the potent to predict the efficacy of camrelizumab plus chemotherapy.

14.
Nutrients ; 13(11)2021 Oct 22.
Artigo em Inglês | MEDLINE | ID: mdl-34835986

RESUMO

The use of dietary supplements is common in the general population and even more prevalent among cancer survivors. The World Cancer Research Fund/American Institute for Cancer Research specifies that dietary supplements should not be used for cancer prevention. Several dietary supplements have potential pharmacokinetic and pharmacodynamic interactions that may change their clinical efficacy or potentiate adverse effects of the adjuvant endocrine therapy prescribed for breast cancer treatment. This analysis examined the prevalence of self-reported dietary supplement use and the potential interactions with tamoxifen and aromatase inhibitors (AIs) among breast cancer survivors enrolled in three randomized controlled trials of lifestyle interventions conducted between 2010 and 2017. The potential interactions with tamoxifen and AIs were identified using the Natural Medicine Database. Among 475 breast cancer survivors (2.9 (mean) or 2.5 (standard deviation) years from diagnosis), 393 (83%) reported using dietary supplements. A total of 108 different types of dietary supplements were reported and 36 potential adverse interactions with tamoxifen or AIs were identified. Among the 353 women taking tamoxifen or AIs, 38% were taking dietary supplements with a potential risk of interactions. We observed a high prevalence of dietary supplement use among breast cancer survivors and the potential for adverse interactions between the prescribed endocrine therapy and dietary supplements was common.

15.
Aging (Albany NY) ; 13(22): 24686-24709, 2021 Nov 27.
Artigo em Inglês | MEDLINE | ID: mdl-34837690

RESUMO

Although endometrioid carcinoma (EC) and endometrioid ovarian carcinoma (EnOC) display similar pathological features, their molecular characteristics remain to be determined. Somatic mutation data from 2777 EC, 423 EnOC, and 57 endometriosis patients from the Catalogue of Somatic Mutations in Cancer (COSMIC) dataset were analyzed and showed similar profiles with different mutation frequencies among them. By using 275 overlapping mutated genes, EC was clustered into two groups with different disease outcomes and different clinical characteristics. Although BRCA-associated mutation characteristics were identified in both EC and EnOC, the mutation frequencies of BRCA1 (P=0.0146), BRCA2 (P=0.0321), ATR (P=3.25E-11), RAD51 (P=3.95E-08), RAD1 (P=0.0003), TP53 (P=6.11E-33), and BRIP1 (P=2.90E-09) were higher in EnOC. Further analysis showed that EnOC cell lines with BRCA-associated mutation characteristics were more sensitive to poly ADP-ribose polymerase (PARP) inhibitors than EC cell lines, including olaparib, talazoparib, rucaparib, and veliparib. Moreover, based on BRCA-associated mutational and transcriptomic profiles, EC with BRCA-associated mutational burdens shows lower levels of immune cell infiltration, higher expression of immunosuppressive checkpoint molecules and worse prognosis than EC without BRCA mutation. Our study comprehensively analyzed the genome mutation features of EC and EnOC and provide insights into the molecular characteristics of EC and EnOC.

16.
Microbiol Res ; 255: 126921, 2021 Nov 16.
Artigo em Inglês | MEDLINE | ID: mdl-34839170

RESUMO

Colorectal cancer (CRC) is the third most common malignant tumor in the world. Previous research has shown that Lacticaseibacillus paracasei strains and its cultures have anti-colon cancer effects, but the study of L. paracasei-derived extracellular vesicles (LpEVs) as intercellular communication molecule against colon cancer has not been previously reported. Our research showed LpEVs were taken in by colorectal cancer cells. Subsequently, LpEVs inhibited the proliferation, migration, invasion and promote apoptosis of colorectal cancer cells. LpEVs inhibited the growth of CRC xenograft in nude mice and promoted tumor apoptosis in vivo. Transcriptome sequencing analysis revealed that differentially expressed genes were involved in the regulation of apoptosis. LpEVs significantly inhibited the phosphorylation level of 3-phosphoinositide-dependent protein kinase-1 (PDK1) and AKT in colorectal cancer cells and reduced the expression of Bcl-2 protein. In conclusion, extracellular vesicles of Lacticaseibacillus paracasei PC-H1 can inhibit the growth of colorectal cancer cells in vivo and vitro and induce apoptosis through PDK1/AKT/Bcl-2 signaling pathway. This research not only provides a new mechanism for the anti-tumor effects of probiotics, but also opens up new opportunity for the treatment of colon cancer.

17.
Waste Manag ; 2021 Nov 25.
Artigo em Inglês | MEDLINE | ID: mdl-34840025

RESUMO

The cone angle of a hydrocyclone is believed to be an important parameter to affect the separation performance. For the recycling of waste plastics, this paper focused on the study of the influence of cone angles on the separation of light dispersed plastics (PET) and heavy dispersed plastics (PVC) by experiments and numerical simulations. The cone angle was changed from 3° to 28° either at given length of the cylindrical section or at fixed total length of the hydrocyclone. The separation performance varied with cone angles at given length of the cylindrical section more greatly than that at fixed total length of the hydrocyclone. Results show that particles with different sizes in mixture exhibited discrepant separation behaviors at various cone angles. There was an optimum cone angle at which the Newton efficiency peaked as 90.2%, while the purity of PET could also reach the highest. The proportion of cylindrical section could be properly small for the enhancement of Newton efficiency.

18.
Cytotechnology ; 73(6): 775-785, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34776628

RESUMO

Psoriasis is a skin disorder that is classed as an autoimmune disease. It is characterized by excessive proliferation, abnormal migration and differentiation of keratinocytes, as well as inflammatory cell infiltration. Circular RNAs (circRNAs/circ) have been reported to play an important role in several aspects of psoriasis. Thus in the present study, the role of circ-insulin-like growth factor 1 receptor (circ-IGF1R) in the development of psoriasis was assessed, and the involvement of microRNA (miR)-194-5p was also investigated as its expression was downregulated in psoriasis. StarBase analysis and dual luciferase reporter assays confirmed the interaction between circ-IGF1R with miR-194-5p. The increased expression of circ-IGF1R and decreased expression of miR-194-5p were further confirmed by reverse transcription-quantitative polymerase chain reaction in interleukin (IL-22)-stimulated HaCaT cells. The increased proliferation, migration and invasion, as well as decreased apoptosis, caspase 3 activity and cleaved-caspase 3/caspase 3 ratio were observed in IL-22-stimulated HaCaT cells. Conversely, transfection of circ-IGF1R-small interfering (si)RNA resulted in significantly increased expression of miR-194-5p with or without stimulation of IL-22 in HaCaT cells, and also overcame the effects of the miR-194-5p inhibitor. Additionally, transfection of circ-IGF1R-siRNA inhibited cell proliferation, migration and invasion, which were reversed by transfection of a miR-194-5p inhibitor. Similarly, circ-IGF1R-siRNA promoted apoptosis, caspase 3 activity and the cleaved-caspase 3/caspase 3 ratio, which were reversed by miR-194-5p inhibitor. These results showed that circ-IGF1R could affect the proliferation, apoptosis, migration and invasion of IL-22-stimulated HaCaT cells by regulating the expression of miR-194-5p. Based on TargetScan prediction and dual luciferase reporter assays, it was shown that cyclin-dependent kinase (CDK)1 was targeted by miR-194-5p. Additionally, the expression of CDK1 was upregulated following stimulation with IL-22 in HaCaT cells at the mRNA and protein levels. Transfection of miR-194-5p mimic or miR-194-5p inhibitor negatively regulated CDK1 expression in the IL-22 induced HaCaT cells. In conclusion, circ-IGF1R-siRNA could inhibit the cell proliferation, migration and invasion, and induce apoptosis by regulating the miR-194-5p/CDK1 axis. circ-IGF1R may thus serve as a potential treatment target for psoriasis.

19.
Comput Intell Neurosci ; 2021: 1502932, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34745245

RESUMO

Accurate electricity load forecasting is an important prerequisite for stable electricity system operation. In this paper, it is found that daily and weekly variations are prominent by the power spectrum analysis of the historical loads collected hourly in Tai'an, Shandong Province, China. In addition, the influence of the extraneous variables is also very obvious. For example, the load dropped significantly for a long period of time during the Chinese Lunar Spring Festival. Therefore, an artificial neural network model is constructed with six periodic and three nonperiodic factors. The load from January 2016 to August 2018 was divided into two parts in the ratio of 9 : 1 as the training set and the test set, respectively. The experimental results indicate that the daily prediction model with selected factors can achieve higher forecasting accuracy.


Assuntos
Eletricidade , Redes Neurais de Computação , China , Previsões , Estações do Ano
20.
Front Med (Lausanne) ; 8: 754890, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34746191

RESUMO

Objective: To systematically evaluate lymph node metastasis (LNM) patterns in patients with endometrial cancer (EC) who underwent complete surgical staging, which included systematic pelvic and para-aortic lymphadenectomy. Methods: Four thousand and one patients who underwent complete surgical staging including systematic pelvic and para-aortic lymphadenectomy for EC were enrolled from 30 centers in China from 2001 to 2019. We systematically displayed the clinical and prognostic characteristics of patients with various LNM patterns, especially the PLN-PAN+ [para-aortic lymph node (PAN) metastasis without pelvic lymph node (PLN) metastasis]. The efficacy of PAN+ (para-aortic lymph node metastasis) prediction with clinical and pathological features was evaluated. Results: Overall, 431 of the 4,001 patients (10.8%) showed definite LNM according to pathological diagnosis. The PAN+ showed the highest frequency (6.6%) among all metastatic sites. One hundred fourteen cases (26.5%) were PLN-PAN+ (PAN metastasis without PLN metastasis), 167 cases (38.7%) showed PLN+PAN-(PLN metastasis without PAN metastasis), and 150 cases (34.8%) showed metastasis to both regions (PLN+PAN+). There was also 1.9% (51/2,660) of low-risk patients who had PLN-PAN+. There are no statistical differences in relapse-free survival (RFS) and disease-specific survival (DSS) among PLN+PAN-, PLN-PAN+, and PLN+PAN+. The sensitivity of gross PLNs, gross PANs, and lymphovascular space involvement (LVSI) to predict PAN+ was 53.8 [95% confidence interval (CI): 47.6-59.9], 74.2 95% CI: 65.6-81.4), and 45.8% (95% CI: 38.7-53.2), respectively. Conclusion: Over one-fourth of EC patients with LMN metastases were PLN-PAN+. PLN-PAN+ shares approximate survival outcomes (RFS and DSS) with other LNM patterns. No effective clinical methods were achieved for predicting PAN+. Thus, PLN-PAN+ is a non-negligible LNM pattern that cannot be underestimated in EC, even in low-risk patients.

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