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1.
Mikrobiol Z ; 70(4): 18-24, 2008.
Artigo em Russo | MEDLINE | ID: mdl-19044007

RESUMO

It has been shown that biotopes of upper respiratory system and intestine were contaminated with yeast in 44.6% of patients with leukaemia (of 112 examined ones). Their quantity exceeds the boundary value for practically healthy people and is > or = 10(2) KOE/ml in the nasal activity and fauces and < or = 10(4) KOE/g in the intestine. It was established that in patients with leucemia the mycotic complications are mainly caused by anamorphous yeast of ascomycetic affinity. Candida albicans, as well as C. glabrata, C. rugosa and Candida sp. play the leading role. The Candida genus species are mainly sensitive to amphotericine B, clotrisamol and nistatin.


Assuntos
Intestinos/microbiologia , Leucemia/microbiologia , Micoses/prevenção & controle , Infecções Oportunistas/prevenção & controle , Sistema Respiratório/microbiologia , Leveduras/isolamento & purificação , Adulto , Idoso , Antifúngicos/farmacologia , Humanos , Leucemia/complicações , Testes de Sensibilidade Microbiana , Pessoa de Meia-Idade , Micoses/complicações , Micoses/microbiologia , Infecções Oportunistas/complicações , Infecções Oportunistas/microbiologia , Leveduras/efeitos dos fármacos , Adulto Jovem
2.
Lik Sprava ; (8): 74-6, 2005 Dec.
Artigo em Russo | MEDLINE | ID: mdl-16498790

RESUMO

A new donor antidiphtheritic immunoglobulin produced in the Hematology and Transfusiology Institute of AMS of Ukraine and Donetsk transfusiology station is discussed in the article. The medication, antidiphtheritic horse serum had been used during the diphtheria epidemic, as a medication in Donetsk clinics. The medication meets requirements of State and International Standards and is registered in Ukraine.


Assuntos
Antitoxina Diftérica/uso terapêutico , Difteria/tratamento farmacológico , Soros Imunes/imunologia , Imunoglobulinas/uso terapêutico , Animais , Doadores de Sangue , Difteria/imunologia , Antitoxina Diftérica/administração & dosagem , Cavalos , Humanos , Soros Imunes/administração & dosagem , Imunoglobulinas/administração & dosagem , Injeções Intramusculares , Ucrânia
4.
Mikrobiol Z ; 61(5): 85-96, 1999.
Artigo em Russo | MEDLINE | ID: mdl-10643278

RESUMO

An analytical survey of literature on the problem of the study of interrelations between the immune status of the organism and microbial ecology of a man is presented. The criteria which characterize normal flora of human organism varying in the process of evolutionary adaptation, interaction with microorganism and response of the immune system, its participation in formation of protective functions of the organism are considered. It is shown that the proceeding character and the finite result of different infectious processes depend on the state of the organism immune system. A possibility of correction of certain immunological indices with the help of representatives of normal microflora has been considered. A conclusion has been made on the necessity to solve the problem of infectious diseases and complications in a complex of microbiological and immunological investigations.


Assuntos
Bactérias/patogenicidade , Ecossistema , Imunidade , Bactérias/imunologia , Infecções Bacterianas/imunologia , Infecções Bacterianas/microbiologia , Humanos , Sistema Imunitário/imunologia , Sistema Imunitário/microbiologia , Fagocitose/imunologia , Valores de Referência
5.
Mikrobiol Z ; 60(4): 88-92, 1998.
Artigo em Russo | MEDLINE | ID: mdl-9859645

RESUMO

Morphological-cultural and physiological-biochemical properties of 24 strains of microorganisms agents of pyo-inflammatory complications of different localization in patients with hemophilia have been studied. Microorganisms strains presented by the following species: Staphylococcus aureus, S. epidermidis, S. saprophyticus, Proteus vulgaris, P. morganii, Hafnia alvei, Serratia marcescens, have been identified. It was found out that in monoculture staphylococci prove to be the leading etiological agent (60.9%), gram-negative enterobacteria (52.2%) and bacterial associations (8.7%) occur more rarely. Special attention was paid to the study of resistance of antibiotics, circulation and pathogenicity factors that had a direct effect on the main disease severity. It was ascertained that high activity of enzymes and presence of pathogenicity factors were the peculiarities of microorganisms isolated from pyo-septic sites in patients with hemophilia. All the strains possessed multiple resistance to antibiotics.


Assuntos
Bactérias/isolamento & purificação , Hemofilia A/complicações , Hemofilia A/microbiologia , Antibacterianos/farmacologia , Bactérias/classificação , Bactérias/efeitos dos fármacos , Infecção Focal/microbiologia , Humanos , Articulações/microbiologia , Testes de Sensibilidade Microbiana , Prognóstico , Infecção da Ferida Cirúrgica/microbiologia , Infecção dos Ferimentos/microbiologia
8.
Lik Sprava ; (5-6): 87-91, 1994.
Artigo em Russo | MEDLINE | ID: mdl-7831922

RESUMO

Studied were particular features of peripheral blood, certain immunological and biochemical indices under long-term exposure of human body to radiation after the accident at the Chernobyl Nuclear Power Plant. The study comprised 5578 individuals. The examinees were liquidators of the Chernobyl accident sequels (n = 1052), inhabitants of Pripyat evacuated from the town (n = 850), the Kiev SSBT primary donors (n = 1738). Control group consisted of 936 Kievans who had been examined before the accident between 1982-1985 by the same methods. The results obtained allowed for the most informative indices to be found in order that risk groups might be formed.


Assuntos
Contaminação Radioativa do Ar/efeitos adversos , Exposição Ambiental/efeitos adversos , Centrais Elétricas , Liberação Nociva de Radioativos , Contaminação Radioativa do Ar/estatística & dados numéricos , Formação de Anticorpos/efeitos da radiação , Sangue/efeitos da radiação , Exposição Ambiental/estatística & dados numéricos , Humanos , Imunidade Celular/efeitos da radiação , Fígado/efeitos da radiação , Doses de Radiação , Liberação Nociva de Radioativos/estatística & dados numéricos , Medição de Risco , Fatores de Risco , Ucrânia , População Urbana/estatística & dados numéricos
11.
Lik Sprava ; (2-3): 65-7, 1993.
Artigo em Russo | MEDLINE | ID: mdl-8191740

RESUMO

The possibility was studied of obtaining of a highly-specific antirabies plasma from donor blood actively immunized with concentrated culture antirabies vaccine and optimal terms were determined for obtaining immunoreactive raw material for manufacturing of antirabies immunoglobulin. Technical aspects of manufacturing antirabies donor plasma are discussed.


Assuntos
Doadores de Sangue , Plasma/imunologia , Vacinas Antirrábicas/isolamento & purificação , Anticorpos Antivirais/sangue , Especificidade de Anticorpos , Humanos , Imunoglobulina G/sangue , Testes de Neutralização , Plasmaferese , Vacinas Antirrábicas/administração & dosagem , Vacinas Antirrábicas/imunologia , Vírus da Raiva/imunologia , Fatores de Tempo , Vacinação
12.
Klin Khir ; (3): 12-4, 1992.
Artigo em Russo | MEDLINE | ID: mdl-1619855

RESUMO

Antiproteic donor plasma was included into the complex of treatment of 54 severely burned children, who had their clinical state, immunologic and hematologic indices been studied. A pronounced therapeutic effect of antiproteic immunotherapy was noted.


Assuntos
Queimaduras/terapia , Imunoterapia/métodos , Plasma/imunologia , Proteínas/imunologia , Queimaduras/imunologia , Criança , Humanos
13.
Artigo em Russo | MEDLINE | ID: mdl-1414104

RESUMO

The comparative study of the isolation rate, level, antigenic and class specificity of serum antibodies to the causative agents of purulent septic infections (Staphylococcus aureus, Pseudomonas aeruginosa, Proteus mirabilis) and acute enteric infections in healthy adults with different ABO blood groups before (836 persons) and after (1,429 persons) the catastrophe at the Chernobyl nuclear power station was made. The study revealed the fact that the genesis of antibodies directed against different microorganisms can be stimulated without additional antigenic challenge in the form of disease or immunization, which was definitely indicative of the influence of small radiation doses in Kiev on the humoral immunity of the population. The multifactor character of the dependence of antibacterial antibody formation under altered radiation conditions on the specific features of the infective agent and the intensity of its circulation among the population, individual immune responsiveness of the body and concrete radiation conditions was established.


Assuntos
Acidentes , Infecções Bacterianas/imunologia , Reatores Nucleares , Centrais Elétricas , Adulto , Anticorpos Antibacterianos/sangue , Anticorpos Antibacterianos/efeitos da radiação , Formação de Anticorpos/efeitos da radiação , Relação Dose-Resposta à Radiação , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de Tempo , Ucrânia , População Urbana
14.
Fiziol Zh ; 37(5): 81-7, 1991.
Artigo em Russo | MEDLINE | ID: mdl-1790822

RESUMO

The experiments on 52 rabbits have been carried out to show the possibility to use Proteus antigen with high content of H-component (H1; H2; H3 Proteus antigens are most frequently found) for active immunization to make highly specific humoral immunity. The optimal scheme of immunization consists of 3 subcutaneous injections in doses of 0.25-0.25-0.5 mg of antigen within 7 days intervals and 0.25 mg dose of single revaccination. The duration of cycle immunization is 14 days.


Assuntos
Formação de Anticorpos/imunologia , Antígenos de Bactérias/imunologia , Imunização , Proteus/imunologia , Animais , Coelhos
15.
Vrach Delo ; (5): 35-8, 1991 May.
Artigo em Russo | MEDLINE | ID: mdl-1866911

RESUMO

A study is presented of homeostasis in 18 volunteer donors after immunisation with Proteus vaccine and in the dynamics of subsequent plasmapheresis for 12 months. It was shown that as a result of anti-Proteus immunisation there occurs an increase of the titer of anti-Proteus antibodies in the blood serum which was maintained at a high level in the course of plasmapheresis for three months. Indices of the peripheral blood, urine, liver function, humoral unspecific and cellular immunity were within normal levels. The blood of donors immunized with Proteus vaccine is a source of obtaining anti-Proteus plasma--an immune allogenous preparation for complex treatment of patients with severe forms of diseases of Proteus etiology.


Assuntos
Vacinas Bacterianas/imunologia , Doadores de Sangue , Plasma/imunologia , Plasmaferese , Proteus mirabilis/imunologia , Adulto , Anticorpos Antibacterianos/sangue , Humanos , Imunidade/imunologia , Imunização , Imunoglobulinas/análise , Fagocitose/imunologia
16.
Vrach Delo ; (4): 65-7, 1991 Apr.
Artigo em Russo | MEDLINE | ID: mdl-2063572

RESUMO

Twenty patients with chronic myeloleucosis in the stage of blast crisis were examined. Results of immunological investigations indicate that these patients showed below normal indices of the absorptive and bactericidal function of polymorphous-nuclear neutrophils and cationic proteins. The number of T- and B-lymphocytes was also reduced. The immunity values were to the same degree inhibited as in patients with acute leucosis. Changes of the immune status depend on the degree of blastemia. Along with cytostatic agents patients with chronic myeloleucosis in the stage of blast crisis should undergo immunocorrection, primarily correction of cellular immunity.


Assuntos
Crise Blástica/imunologia , Leucemia Mielogênica Crônica BCR-ABL Positiva/imunologia , Formação de Anticorpos/imunologia , Humanos , Imunidade Celular/imunologia , Leucemia Mieloide Aguda/imunologia , Fagocitose/imunologia , Leucemia-Linfoma Linfoblástico de Células Precursoras/imunologia
18.
Mikrobiol Zh ; 52(3): 63-5, 1990.
Artigo em Russo | MEDLINE | ID: mdl-2215288

RESUMO

Blast transformation of peripheral blood lymphocytes in healthy people is studied by enzymes of the microbic origin possessing the lectin activity. Galactose oxidase of Fusarium graminearum IMV-F-1060 is shown to be mitogenically active with respect to the lymphocytes in the culture in vitro and may be one of home sources of lymphocytic mitogens for the laboratory investigations.


Assuntos
Fusarium/enzimologia , Mitógenos/farmacologia , Rhodococcus/enzimologia , Escherichia coli , Galactose Oxidase/isolamento & purificação , Galactose Oxidase/farmacologia , Humanos , Lipopolissacarídeos/farmacologia , Ativação Linfocitária/efeitos dos fármacos , Manosidases/isolamento & purificação , Manosidases/farmacologia , Fito-Hemaglutininas/farmacologia
19.
Vrach Delo ; (1): 90-3, 1990 Jan.
Artigo em Russo | MEDLINE | ID: mdl-1970445

RESUMO

The authors evaluate a method of procuring and preserving fetal liver cells in a medium containing low-molecular polyvynilpyrrolidon, glucose, lactose, sodium phosphate and sodiumhydrocitrate not requiring washing off. The biomaterial is stored at a temperature of -196 degrees C. The efficiency of this method of cryopreservation of fetal liver cell suspensions was confirmed by high morphological intactness, functional activity and proliferative capacity. Patients with hypoplastic anemia subjected to transfusion of cryopreserved fetal liver cells showed a normalization of bone marrow hemopoiesis, remissions.


Assuntos
Criopreservação/métodos , Transplante de Fígado/métodos , Fígado/citologia , Anemia Aplástica/congênito , Anemia Aplástica/terapia , Contagem de Células , Divisão Celular , Sobrevivência Celular , Células Cultivadas , Criança , Cultura em Câmaras de Difusão , Feto , Transplante de Células-Tronco Hematopoéticas , Células-Tronco Hematopoéticas/citologia , Humanos , Suspensões
20.
Vrach Delo ; (5): 123-4, 1989 May.
Artigo em Russo | MEDLINE | ID: mdl-2505453

RESUMO

The authors studied the immune response of the body of 23 donors formerly hyperimmunized with staphylococcal anatoxin to pyocyaneus antigen. It was established that immunization of these donors with Bacillus pyocyaneus anatoxin did not produce pathological reactions of the body, resulted in activation of the immune systems and production and antipyocyaneus antibodies.


Assuntos
Formação de Anticorpos , Antígenos de Bactérias/imunologia , Imunização , Pseudomonas aeruginosa/imunologia , Toxoide Estafilocócico/imunologia , Toxoides/imunologia , Humanos
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