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1.
Sante Publique ; Vol. 31(3): 433-441, 2019.
Artigo em Francês | MEDLINE | ID: mdl-31640331

RESUMO

OBJECTIVES: Non-communicable diseases (NCDs) represent a major public health problem worldwide. Giving their impact on the morbidity and mortality burden, understanding their chronological trends over time is a priority for epidemiological surveillance. We aimed to determine the epidemiological specificities of NCDs and to study their chronological trends over the period 2010-2015. METHODS: We retrospectively collected data of hospitalized patients from the regional registry of morbidity and mortality in the Southern University Hospital of Tunisia during the period 2010-2015. RESULTS: We included 18,081 patients with NCDs aged ≥ 25 years. The distribution of NCDs was characterized by the predominance of cardiovascular disease (CVD) (10,346 cases, 57.2%). Chronological trends analysis of NCDs showed that NCDs remained globally stable between 2010 and 2015. The same result applied to the group of cancers, chronic respiratory diseases and diabetes mellitus. However, CVD increased significantly between 2010 and 2015 (ρ = 0.84; p = 0.036). The proportion of CVD increased significantly among men (ρ = 0.87; p = 0.019) and elderly (ρ = 0.88; p = 0.019). The hospital mortality rate of NCDs increased significantly (ρ = 0.85; p = 0.031), notably for CVDs (ρ = 0.94; p = 0.005). CONCLUSION: Chronological trends analysis revealed a significant rise in the morbidity and mortality burden of CVDs during the period 2010-2015. It is imperative, therefore, to strengthen health care for these patients and to introduce the concept of integrated NCDs prevention as an essential component of the health system.


Assuntos
Doenças não Transmissíveis/epidemiologia , Adulto , Idoso , Doenças Cardiovasculares/epidemiologia , Doenças Cardiovasculares/mortalidade , Humanos , Masculino , Morbidade/tendências , Mortalidade/tendências , Doenças não Transmissíveis/mortalidade , Sistema de Registros , Estudos Retrospectivos , Tunísia/epidemiologia
2.
Artigo em Inglês | MEDLINE | ID: mdl-31100056

RESUMO

Background Body image is considered as central to many aspects of human functioning including emotions, thoughts, behaviors and relationships. Our study aimed to investigate the prevalence of body image distortion and dissatisfaction among adolescents and to assess their main determinants. Methods This was a cross-sectional school-based study conducted among school-adolescents in the south of Tunisia, between October 2017 and February 2018. Results Among 1210 school-adolescents, body image distortion and dissatisfaction prevalence were 44.8% and 42.4%, respectively. Multivariate analysis showed that being in the 16-18 years age group [adjusted odds ratio (AOR) = 1.28, p = 0.046], low family financial situation (AOR = 1.88, p = 0.014), as well as high frequency of eating pasta (AOR = 1.3, p = 0.04) and fast-food consumption (AOR = 1.7, p = 0.042) were independently associated with under-estimated body image. Skipping breakfast (AOR = 1.9, p = 0.017) and having one obese parent (AOR = 1.9, p = 0.01) were independently associated with higher frequency of over-estimated body image. Regarding body image dissatisfaction, independent factors associated with desire to lose weight were: female gender (AOR = 1.53, p = 0.007), high income family financial situation (AOR = 2.1, p = 0.008) and having one parent who is obese (AOR = 2.21, p < 0.001). However, frequent fast-food consumption (AOR = 1.9, p = 0.038) and eating between meals (AOR = 1.57, p = 0.01) were independently associated with a higher desire to gain weight. Conclusions Our study highlighted that the prevalence of body image distortion and dissatisfaction were substantially high among adolescents. Their determinants included socio-demographic factors and lifestyle behaviors. Increased awareness among parents, educators and public health planners may help adolescents improve accuracy of body image attitudes.

3.
J Res Health Sci ; 19(1): e00440, 2019 Mar 26.
Artigo em Inglês | MEDLINE | ID: mdl-31133629

RESUMO

BACKGROUND: Musculoskeletal pain (MSP) is a public health problem among school-adolescents. This study aimed to identify the prevalence, risk factors and consequences of neck, shoulders and low-back pain among school-adolescents. STUDY DESIGN: A cross-sectional study. METHODS: School-adolescents aged from 12 to 18 years between October 2017 and February 2018 in South of Tunisia were recruited. Eligible participants were randomly selected and were asked to respond a four-section questionnaire. Factors independently associated with MSP were determined through multivariate logistic regression analysis. RESULTS: Among 1221 enrolled subjects, shoulders, low-back and neck pain were reported in 43%, 35.8% and 32%, respectively. Multivariate analysis showed that independent risk factors of neck pain were female gender (Adjusted odds ratio AOR=1.55; P=0.002), using computer ≥4 hours/week (AOR=1.50; P=0.010), too low desk (AOR=2.30; P<0.001) and carrying schoolbag ≥60 minutes (AOR=1.58; P=0.008). Female gender (AOR=3.30; P<0.001), BMI ≥25 Kg/m2 (AOR=1.6; P=0.018), playing videogames ≥2 hours/day (AOR=2.37; P<0.001) and schoolbag weight to body weight ≥10% (AOR=1.46; P=0.026) were independently associated with shoulders pain. For low back-pain, independent risk factors were high-school grade (AOR=2.70; P<0.001), playing videogames ≥2 hours/day (AOR=1.83; P<0.001), watching TV≥12 hours/week (AOR=1.5; P=0.016), too low seat backrest (AOR=1.4; P=0.005) and too far seat-to-black (board) distance (AOR=1.5; P=0.041). School-adolescents consumed drugs for MSP in 19.5%, had sleep disturbance in 34% and aggressive behaviors in 22.8%. CONCLUSIONS: The prevalence of MSP was substantially high among school-adolescents and their associated risk factors included sociodemographic factors, leisure activities and classroom furniture. An ergonomic specific and behavior-based school program is urgently needed.


Assuntos
Dor Lombar/etiologia , Dor Musculoesquelética/etiologia , Cervicalgia/etiologia , Instituições Acadêmicas , Dor de Ombro/etiologia , Estudantes , Adolescente , Dorso , Índice de Massa Corporal , Criança , Estudos Transversais , Ergonomia , Feminino , Humanos , Atividades de Lazer , Modelos Logísticos , Dor Lombar/tratamento farmacológico , Dor Lombar/epidemiologia , Masculino , Dor Musculoesquelética/tratamento farmacológico , Dor Musculoesquelética/epidemiologia , Pescoço , Cervicalgia/tratamento farmacológico , Cervicalgia/epidemiologia , Prevalência , Fatores de Risco , Tempo de Tela , Ombro , Dor de Ombro/tratamento farmacológico , Dor de Ombro/epidemiologia , Inquéritos e Questionários , Tunísia/epidemiologia
4.
Am J Infect Control ; 47(8): 945-950, 2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-30777390

RESUMO

BACKGROUND: The aim of this study was to determine the prevalence of health care-associated infections (HAI) in our university hospitals (UH) and to delineate the risk factors associated with HAI. METHODS: We conducted a cross-sectional study in the 2 UH of Sfax, Tunisia on July 2017, including all patients hospitalized for at least 48 hours. It was a 1-day pass per department and a 1-week prevalence survey per UH. RESULTS: Of 752 patients eligible for the study, the total number of HAI was 82, representing an overall prevalence of HAI of 10.9%. Respiratory tract infections were the most prevalent HAI (36.6%). In multivariate analysis, intrinsic risk factors independently associated with HAI were immune-suppression (adjusted odds ratio (AOR) = 2.8; P < .001), diabetes (AOR = 2.2; P = .008), and malnutrition (AOR = 2.2; P = .019). Extrinsic risk factors were endotracheal intubation (AOR = 17; P = .01), transfer to another department (AOR = 9; P = .019), parental feeding (AOR = 7.2; P = .014), tobacco use (AOR = 6.3; P = .004), as well as surgical wound class contaminated or dirty (AOR = 6.3; P = .002), and peripheral venous catheter (AOR = 4.7; P = .006). CONCLUSIONS: Our study highlighted the magnitude of the HAI problem threatening the quality of care in Southern Tunisia. A wise identification of HAI risk factors may help health care workers to ascertain the avoidability of these infections.

5.
Pediatr Int ; 60(1): 76-82, 2018 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-28891268

RESUMO

BACKGROUND: The aim of this study was to describe the epidemiological profile of childhood respiratory tract diseases (RTD) in the region of Sfax, Tunisia, and to evaluate their trends over a 13 year period. METHODS: We conducted a retrospective study of all children hospitalized with RTD aged under 14 years. We collected data from the regional morbidity register of the university hospital of Sfax from 2003 to 2015. RESULTS: A total of 10 797 RTD patients were enrolled from 49 880 pediatric hospitalizations (21.7%). A male predominance was noted (60%). The median age was 8 months (IQR, 2-36 months). Acute bronchitis (AB) accounted for 53.8%, followed by asthma (15%), pneumonia (14%) and acute upper respiratory infection (AURI; 7.2%). The hospital incidence rate (HIR) of RTD was 34/10 000 inhabitants/year. It was 18.2; 5.07; 4.7 and 2.4/10 000 inhabitants for AB, asthma, pneumonia and AURI, respectively. We noted a significant increase in the HIR of RTD with an annual percentage change (APC) of 10.94% (P < 0.001); in the HIR of AB (APC, 5.27%; P < 0.001); and in asthma HIR (APC, 11.2%; P < 0.001). Otherwise, a significant decrease in AURI HIR was observed (APC, -8.8%; P < 0.001). AB lethality rate increased significantly, with an APC of 7.4% (P < 0.001). Projected trends analysis up to 2024 showed a significant rise in AB and in asthma, while AURI would significantly decrease. CONCLUSIONS: RTD continues to be a serious health problem over time in terms of morbidity and mortality. Preventive and curative strategies are needed urgently.


Assuntos
Doenças Respiratórias/epidemiologia , Adolescente , Criança , Pré-Escolar , Feminino , Hospitalização/tendências , Humanos , Lactente , Recém-Nascido , Masculino , Sistema de Registros , Estudos Retrospectivos , Tunísia/epidemiologia
6.
Spectrochim Acta A Mol Biomol Spectrosc ; 136 Pt B: 397-404, 2015 Feb 05.
Artigo em Inglês | MEDLINE | ID: mdl-25311521

RESUMO

Single crystals of a new organic-inorganic compound (C9H24N2) CdCl4 were grown by the slow evaporation technique and characterized by X-ray diffraction, infrared absorption Raman spectroscopy scattering, optical absorption, differential scanning calorimetry (DSC) analysis and dielectric measurements. The title compound belongs to the orthorhombic space group Pbca with the following unit cell parameters: a=11.397(7), b=13.843(4), c=22.678(5)Šand Z=8. In crystal structure, the tetrachlorocadmate anion is connected to organic cations through N-H⋯Cl hydrogen bonds. Theoretical calculations were performed using density functional theory (DFT) with the B3LYP/LanL2DZ level of theory for studying the molecular structure and vibrational spectra of the title compound. Good consistency is found between the calculated results and the experimental structure, IR, and Raman spectra. The detailed interpretation of the vibrational modes was carried out on the basis on our DFT calculations as primary source of assignment and by comparison with spectroscopic studies of similar compounds. The optical properties were investigated by optical absorption and show three bands at 300, 329 and 513 nm.


Assuntos
Complexos de Coordenação/química , Diaminas/química , Modelos Moleculares , Fenômenos Ópticos , Teoria Quântica , Análise Espectral Raman , Vibração , Varredura Diferencial de Calorimetria , Simulação por Computador , Cristalografia por Raios X , Eletricidade , Ligações de Hidrogênio , Espectroscopia de Infravermelho com Transformada de Fourier , Temperatura Ambiente
7.
Spectrochim Acta A Mol Biomol Spectrosc ; 137: 1235-43, 2015 Feb 25.
Artigo em Inglês | MEDLINE | ID: mdl-25305616

RESUMO

A new organic-inorganic material, diethylenetriammonium hexabromobismuthate (C4H16N3)BiBr6, was synthesized and characterized by X-ray diffraction, infrared absorption, Raman spectroscopy scattering and optical absorption. The crystal lattice is composed of discrete [BiBr6] anions surrounded by diethylenetriammonium cations. The title compound crystallizes in the non-centro-symmetric space group P212121 of orthorhombic system. Theoretical calculations were performed using density functional theory (DFT) at B3LYP/LanL2DZ level of theory for studying the molecular structure, vibrational spectra and non-linear optical (NLO) properties of the investigated molecule in the ground state. Good consistency is found between the calculated results and the experimental structure, IR, and Raman spectra. The results also show that the title compound might have important NLO behavior and can be a potential new nonlinear optical (NLO) material of interest.


Assuntos
Compostos de Amônio/química , Bismuto/química , Compostos Organometálicos/química , Cristalização , Cristalografia por Raios X , Halogenação , Modelos Moleculares , Dinâmica não Linear , Teoria Quântica , Espectrofotometria Ultravioleta , Espectroscopia de Infravermelho com Transformada de Fourier , Análise Espectral Raman
8.
Spectrochim Acta A Mol Biomol Spectrosc ; 133: 856-66, 2014 Dec 10.
Artigo em Inglês | MEDLINE | ID: mdl-25014546

RESUMO

Single crystals of 2,5-dimethylanilinium dihydrogen phosphate were grown by slow evaporation method at room temperature. The synthesized compound was characterized by powder X-ray diffraction analysis to confirm its crystalline nature. The optimized molecular structure, vibrational spectra and the optical properties were calculated by the density functional theory (DFT) method using the B3LYP function with the 6-31G(d,p) basis set. Theoretical simulation of infrared and Raman spectra led to excellent overall agreement with the observed spectral patterns. The complete assignments of the vibrational spectra were carried out with the aid of potential energy distribution (PED). The stability of the molecule arising from hyperconjugative interaction and charge delocalization has been analyzed using natural bond orbital (NBO) analysis leading to high nonlinear optical (NLO) activity. The lowering in the HOMO and LUMO energy gap explains the eventual charge transfer interactions that take place within the molecules.


Assuntos
Compostos de Anilina/química , Fosfatos/química , Cristalografia por Raios X , Modelos Moleculares , Conformação Molecular , Teoria Quântica , Espectroscopia de Infravermelho com Transformada de Fourier , Análise Espectral Raman
10.
Spectrochim Acta A Mol Biomol Spectrosc ; 131: 274-81, 2014 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-24835929

RESUMO

Single crystals of tetrapropylammonium dihydrogenmonoarsenate bis arsenic acid [CH3CH2CH2]4N (H2AsO4) (H3AsO4)2, a potential new nonlinear optical (NLO) material of interest were prepared by the slow evaporation technique and characterized by means of single-crystal X-ray diffraction, thermal analysis, FT-IR and Raman spectroscopy. The title compound belongs to the monoclinic space group Ia with the following unit cell dimensions: a=8.116(2) Ǻ, b=33.673(4) Ǻ, c=8.689(2) Ǻ, ß=95.34(2)°. The structure consists of infinite parallel two-dimensional planes built of mutually [H2AsO4(-)] and [H3AsO4] tetrahedra connected by strong O-H⋯O hydrogen bonding giving birth to trimmers. The planes of inorganic groups are alternated with those of the organic cations. The geometry, first hyperpolarizability and harmonic vibrational wavenumbers were calculated by means of density functional theory DFT with the B3LYP/6-31G(d) level of theory. Good consistency was found between the calculated results and the experimental structure, IR, and Raman spectra. The detailed interpretation of the vibrational modes was carried out building on the proposed DFT calculations as primary source of assignment and by comparison with the spectroscopic studies of similar compounds. The first hyperpolarizability ßtot of the title compound is about 14.6 times more than that of the reference crystal KDP, which may explain the importance of the compound under study.


Assuntos
Arseniatos/química , Compostos de Amônio Quaternário/química , Cristalografia por Raios X , Modelos Moleculares , Teoria Quântica , Espectroscopia de Infravermelho com Transformada de Fourier , Análise Espectral Raman , Temperatura Ambiente
11.
Artigo em Inglês | MEDLINE | ID: mdl-24704485

RESUMO

Single crystals of L-asparaginium picrate (LASP) were grown by slow evaporation technique at room temperature and were the subject of an X-ray powder diffraction study to confirm the crystalline nature of the synthesized compound. FT-IR and Raman spectra were recorded and analyzed with the aid of the density functional theory (DFT) calculations in order to make a suitable assignment of the observed bands. The optimum molecular geometry, normal mode wavenumbers, infrared and Raman intensities and the first hyperpolarizability were investigated with the help of B3LYP method using 6-31G(d) basis set. The theoretical FT-IR and Raman spectra of LASP were simulated and compared with the experimental data. A good agreement was shown and a reliable vibrational assignment was made. Natural bond orbital (NBO) analysis was carried out to demonstrate the various inter and intramolecular interactions that are responsible for the stabilization of the title compound leading to high NLO activity. A study on the electronic properties was performed by time-dependent DFT (TD-DFT) approach. The lowering in the HOMO and LUMO energy gap explains the eventual charge transfer interactions that take place within the molecules.


Assuntos
Asparagina/química , Modelos Moleculares , Picratos/química , Estrutura Molecular , Espectroscopia de Infravermelho com Transformada de Fourier/métodos , Análise Espectral Raman/métodos , Difração de Raios X/métodos
12.
Spectrochim Acta A Mol Biomol Spectrosc ; 127: 275-85, 2014 Jun 05.
Artigo em Inglês | MEDLINE | ID: mdl-24632236

RESUMO

Single crystals of 2,5-dimethylanilinim chloride monohydrate were grown by slow evaporation at room temperature and were characterized by X-ray powder diffraction study to confirm the crystalline nature of the synthesized compound. The optimized molecular structure, vibrational spectra and the optical properties were calculated by the density functional theory (DFT) method using the B3LYP function with the 6-31G(d,p) basis set. Simulation of infrared and Raman spectra led to excellent overall agreement with the observed spectral patterns. The complete assignments of the vibrational spectra were carried out with the aid of potential energy distribution (PED). The stability of the molecule arising from hyperconjugative interaction and charge delocalization has been analyzed using natural bond orbital (NBO) analysis leading to high nonlinear optical (NLO) activity. The lowering in the HOMO and LUMO energy gap explains the eventual charge transfer interactions that take place within the molecules.


Assuntos
Compostos de Anilina/química , Cristalização , Espectrofotometria Infravermelho , Análise Espectral Raman , Difração de Raios X
13.
Artigo em Inglês | MEDLINE | ID: mdl-24231749

RESUMO

In this work, we report a combined experimental and theoretical study of a nonlinear optical material, L-Phenylalanine L-Phenylalaninium Perchlorate. Single crystals of the title compound have been grown by slow evaporation of an aqueous solution at room temperature. Theoretical calculations were preceded by redetermination of the crystal X-ray structure. The compound crystallizes in the non-centro symmetric space group P2(1)2(1)2(1) of the orthorhombic system. The FT-IR and Raman spectra of the crystal were recorded and analyzed. The density functional theory (DFT) computations have been performed at B3LYP/6-31G(d) level to derive equilibrium geometry, vibrational wavenumbers, intensity and NLO properties. All observed vibrational bands have been discussed and assigned to normal mode or to combinations on the basis of our DFT calculations as a primary source of attribution and also by comparison with the previous results for similar compounds. Natural bond orbital analysis was carried out to demonstrate the various inter-and intramolecular interaction that are responsible of the stabilization of the compound. The lowering of highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) energy gap appears to be the cause of its enhanced charge transfer interaction leading to high NLO activity.


Assuntos
Modelos Moleculares , Fenômenos Ópticos , Percloratos/química , Fenilalanina/química , Teoria Quântica , Vibração , Ânions , Cristalografia por Raios X , Ligações de Hidrogênio , Conformação Molecular , Espectrofotometria Infravermelho , Análise Espectral Raman , Temperatura Ambiente
14.
Artigo em Inglês | MEDLINE | ID: mdl-23867646

RESUMO

Single crystals of l-leucine l-leucinium picrate were grown by slow evaporation at room temperature and were characterized by X-ray powder diffraction study to confirm the crystalline nature of the synthesized compound. The optimized molecular structure, vibrational spectra and the optical properties were calculated by the Density Functional Theory (DFT) method using the B3LYP function with the 6-31G(d) basis set. Good consistency is found between the calculated results and the experimental structure, IR, and Raman spectra. The detailed interpretation of the vibrational modes was carried out. The natural bond orbital (NBO) analysis, confirms the occurrence of intermolecular hydrogen bonds that are responsible for the stabilization of the title compound, leading to high nonlinear optical (NLO) activity. The lowering in the HOMO and LUMO energy gap explains the eventual charge transfer interactions that take place within the molecules.


Assuntos
Leucina/análogos & derivados , Modelos Moleculares , Dinâmica não Linear , Fenômenos Ópticos , Picratos/química , Teoria Quântica , Vibração , Ânions , Cristalização , Eletricidade , Ligações de Hidrogênio , Leucina/química , Conformação Molecular , Pós , Espectroscopia de Infravermelho com Transformada de Fourier , Análise Espectral Raman , Difração de Raios X
15.
Tunis Med ; 89(10): 745-51, 2011 Oct.
Artigo em Francês | MEDLINE | ID: mdl-22076895

RESUMO

AIM: To study the principal causes of death of the women dead at an âge ranging between 15 and 49 years old and having been hospitalized in a public medical structures of the gouvernorat of Sfax. METHODS: Retrospective study concerning all the included deaths between 1999 and 2007. RESULTS: The study was related to 728 deaths, which correspond to an average of 80.88 deaths FAR per year. Public highway accidents were the major cause of death (83 cases, 11.4 % of the causes of death) followed by the burns (37 cases, 5%) and the cerebral vascular accidents (31 cases, 4.25%). The classification of the causes of death according to groups of pathologies showed the prevalence of the cardio- vascular diseases (18.7%), the external causes of death (18.2%), cancers (11.6%) and the causes related to the pregnancy and the childbirth (8.5%). The maternal death rate was of 56.91 per 100000. The cause of maternal death was directly related to the pregnancy in 67.74 % of the cases. The immediate causes were prevailed by the hemorrhagic causes (27.5%). The death was avoidable in 48.83 % of the cases and the failures were related to the woman in 60% of the cases. CONCLUSION: The prevention of new practices of life (female nicotinism, obesity, bad food habits, lack of vigilance in traffic) and a better practice of the primary and secondary prevention in medicine could decrease the premature death rates in Tunisia.


Assuntos
Causas de Morte/tendências , Acidentes de Trânsito/mortalidade , Adolescente , Adulto , Feminino , Humanos , Mortalidade Materna , Pessoa de Meia-Idade , Gravidez , Estudos Retrospectivos , Tunísia/epidemiologia , Ferimentos e Lesões/mortalidade , Adulto Jovem
16.
Tunis Med ; 88(10): 703-6, 2010 Oct.
Artigo em Francês | MEDLINE | ID: mdl-20890815

RESUMO

BACKGROUND: Fibromyalgia is a chronic, non inflammatory, pain syndrome, characterized by widespread musculoskeletal pain and excessive fatigue. Although it is considered like being the second pathology met in ambulatory rheumatology practice, it is again, poorly understood by medical and scientific community. AIM: value the level of knowledge, attitudes and practices of Tunisian physicians, general practitioners concerning fibromyalgia. METHODS: It was about a cross-sectional survey using questionnaire, achieved by a representative sample of Tunisian physicians, general practitioners. These last, answered a questionnaire previously used in France, in Portugal and in Russia, valuing their knowledge on fibromyalgia, their attitudes and practice in the face of patients suffering from fibromyalgia. RESULTS: Fibromyalgia was recognized as a clinical entity by 26.7% of our physicians. Each general practitioner followed an average of 5.7 patients. The diagnosis of fibromyalgia was made based on widespread pain that persists more than 3 months, sensitive to NSAIDs, for 48% of general practitioners, or on tenderness that occurs in precise, localized areas of the body (trigger points) according to 54% among them. Main symptoms of Fibromyalgia were known with various degrees: pains (87.9%), excessive fatigue (85.7%), muscular weakness (78%), sleeping troubles (65.9%) and psychological disturbance (68.1%). Knowledge of physicians about attitudes and practices in front of cases of fibromyalgia were limited. CONCLUSION: Knowledge of this disease is still mysterious and not well know. General practitioner are aware of fibromyalgia which not included in the program during that training in the medical school. In consequence, our institution, our medical schools in Tunisia should teach this disease to our student and during post graduate courses.


Assuntos
Competência Clínica , Fibromialgia , Adulto , Estudos Transversais , Feminino , Clínicos Gerais , Humanos , Masculino , Inquéritos e Questionários , Tunísia
17.
Tunis Med ; 86(9): 806-11, 2008 Sep.
Artigo em Francês | MEDLINE | ID: mdl-19472780

RESUMO

OBJECTIVE: to estimate fibromyalgia (FM) prevalence in Tunisia. METHODS: Data on a cross-section of 1000 individuals aged 15 years or older living in Sfax were collected by interviewers using the London Fibromyalgia Epidemiology Study Screening Questionnaire (LFES- SQ). The sampling was realized by empirical poll and respecting quota according to delegation, rural or urban environment, sex and age according to the demographic national data. The positive screened subjects were invited to be examined to confirm or exclude the FM by applying the 1999 ACR criteria. The questionnaire was administered to a second group of 252 volunteers, all were afterward examined. This allowed to study specificity and sensibility of the questionnaire and allowed to calculate the FM prevalence. RESULTS: 159 subjects were screened positive, only 141 were examined. The specialized exam allowed confirming the diagnosis of FM in 67 subjects. FM prevalence is different according to sex, age, study level and socio-economic level. Two hundred and fifty two volunteers answered the questionnaire then all examined. The questionnaire specificity was 90.8% and the sensibility 79.4%. FM prevalence in Tunisia, calculated by Bayes theorem, is estimated between 8.27% and 12.3%. CONCLUSION: FM prevalence in Tunisia is estimated at least at 8.27%.


Assuntos
Fibromialgia/epidemiologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Tunísia/epidemiologia , Adulto Jovem
18.
Clin Biochem ; 40(1-2): 41-5, 2007 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-17020757

RESUMO

OBJECTIVES: To test the association between hyperhomocysteinemia (HHC) and deep venous thrombosis (DVT) of lower extremities in Tunisians. DESIGN AND METHODS: This case-control study included 90 patients with DVT of the lower extremities and 160 healthy controls. Plasma homocysteine, vitamin B(12) and folate were determined using immunoenzymatic methods. Logistic regression models were performed to test whether the association between HHC and DVT is independent and to precise determinants of HHC in DVT patients. RESULTS: Plasma total homocysteine concentrations were significantly higher in patients with DVT (17.4+/-11.5 micromol/L) and in patients with idiopathic DVT (15.2+/-6.4 micromol/L) as compared to controls (11.5+/-3.3 micromol/L). HHC was significantly associated (p<0.001) with all DVT (OR, 8.82; 95% CI, 3.96-19.6) as well as idiopathic DVT (OR, 7.40; 95% CI, 3.01-10.8). These associations persisted after adjustment for several thrombosis risk factors. In patients with DVT, HHC was related to folate and vitamin B(12) concentrations, but neither to the type of occurrence nor to the recurrence of DVT. CONCLUSION: HHC is independently associated with first DVT of lower extremities in Tunisians. Homocysteine should be assessed in patients with DVT and the effect of vitamin B supplementation should be tested among them.


Assuntos
Hiper-Homocisteinemia/complicações , Perna (Membro)/patologia , Trombose Venosa/complicações , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Estudos de Casos e Controles , Creatinina/metabolismo , Feminino , Ácido Fólico/sangue , Homocisteína/sangue , Humanos , Hiper-Homocisteinemia/epidemiologia , Masculino , Pessoa de Meia-Idade , Prevalência , Recidiva , Tunísia/epidemiologia , Trombose Venosa/prevenção & controle , Vitamina B 12/sangue
19.
Clin Lab ; 50(7-8): 447-53, 2004.
Artigo em Inglês | MEDLINE | ID: mdl-15330514

RESUMO

This study was aimed to determine the prevalence of several classical and non-classical cardiovascular risk factors, and to test their association with cardiovascular events in Tunisian patients with end-stage renal disease. A total of 35 chronic renal failure, 50 hemodialysed and 30 renal transplant recipient patients and 31 healthy subjects were included. Hypertension, elevated plasma concentrations of total homocysteine, fibrinogen, C-reactive protein, and lipoprotein(a) were highly prevalent in patients, whereas, smoking, hypertriglyceridemia, hypercholesterolemia, hypoHDLemia, and hypoalbuminemia were less common. In univariate analysis, cardiovascular events were associated with age, hypertension, and the top quartile of the total homocysteine and C-reactive protein values. When controlling for several potential confounding factors, cardiovascular events remained associated with age, hypertension (OR, 7.07; 95% CI, 1.76-28.34; P=0.01), and the top quartile of total homocysteine (OR, 10.41; 95% CI, 2.61-41.55; P=0.001) and C-reactive protein (OR, 3.99; 95% CI, 1.06-14.99; P=0.04).


Assuntos
Doenças Cardiovasculares/etiologia , Falência Renal Crônica/complicações , Adulto , Fatores Etários , Proteína C-Reativa/metabolismo , Doenças Cardiovasculares/sangue , Feminino , Fibrinogênio/metabolismo , Imunoensaio de Fluorescência por Polarização , Homocisteína/sangue , Humanos , Hipertensão/complicações , Falência Renal Crônica/sangue , Lipoproteína(a)/sangue , Masculino , Fatores de Risco , Tunísia
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