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1.
J Hazard Mater ; 421: 126711, 2022 01 05.
Artigo em Inglês | MEDLINE | ID: mdl-34332489

RESUMO

Understanding the interactions between oil and other particles in shoreline can help determine the environmental risk and cleanup strategy after oil spill. Nevertheless, far less has been known regarding the impact of aged MPs on oil behavior in the shoreline environment. In this study, the aging course of polyethylene (PE) in shaking seawater and ultraviolet (UV) radiation conditions was investigated. The seawater aging mainly affected the physical properties of MPs, increasing its surface pores and hydrophilicity. UV aging significantly affected both the physical and chemical properties of MPs, which increased its hydrophilicity and crystallinity, decreased its mean particle size and introduced oxygen-containing functional groups onto MPs. The two-dimensional correlation spectroscopy (2D COS) analysis confirmed the evolution of oxygen-containing functional groups from C-O to CO. The effects of aged MPs on oil behavior in water-sand system were further explored. The oil remaining percentages were non-linearly changed with the increasing aging degree of MPs. The particle size of the aqueous phase after washing was inversely related to the oil remaining percentage. Further FTIR analysis revealed that C-O and C-H functional groups played an important role in the process of oil adsorbed on MPs.


Assuntos
Microplásticos , Poluentes Químicos da Água , Plásticos , Polietileno , Água do Mar , Poluentes Químicos da Água/análise
2.
Spectrochim Acta A Mol Biomol Spectrosc ; 265: 120367, 2022 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-34530197

RESUMO

A new fluorescence coordination polymer [Zn(Py2TTz)(5-OH-IPA)]n (1) (Py2TTz = 2,5-bis(4-pyridyl)thiazolo[5,4-d]thiazole, 5-OH-IPA = 5-hydroxyisophthalic acid dianion) was synthesized, which exhibited the characteristics of fluorescence quenching and bathochromic shift toward Hg(II) in aqueous solution at pH 7.00. Mechanism study showed that the interactions between Hg(II) ions and Py2TTz ligands in 1 were responsible for the fluorescence emission change. Thanks to the specific interactions between 1 and Hg(II), excellent selectivity was achieved both in aqueous solution and in solid test paper. The detection limit of 1 for Hg(II) sensing was 125.76 nmol L-1 and a linear rang was 1.00-10.00 µmol L-1. More importantly, satisfactory recovery and accuracy of 1 for Hg(II) sensing were also obtained in buffer-free real water samples.


Assuntos
Mercúrio , Polímeros , Espectrometria de Fluorescência , Tiazóis , Água
3.
J Environ Manage ; 301: 113913, 2022 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-34731942

RESUMO

In-situ burning can be used to prevent oil spreading in oil spill response. In this study, a steady-state Gaussian plume model was applied to analyze the concentration distribution of fine particulate matter produced by in-situ burning, as well as to assess the health risks associated with different combustion methods and ambient conditions, in reference to three simulation scenarios. The spatial and temporal distribution of emission sources can affect the dispersion pattern. The distribution into an array of different burning locations ensures better dispersion of emissions, thereby preventing the formation of high concentration regions. The wind and atmosphere stability play an important role in pollution dispersion. Lower wind and temperature inversion can seriously hinder the diffusion of pollutants. The health risk to technical staff adjacent to the burning areas is a serious concern, and when the community is more than 20 km away from the burning zone, there is few risks. Through simulation, the influences of combustion methods and natural factors on the concentration and diffusion of pollutants are evaluated. The results can help provide an optimized burning strategy for oil spill response in the Arctic area.


Assuntos
Poluentes Atmosféricos , Poluição por Petróleo , Poluentes Atmosféricos/análise , Monitoramento Ambiental , Humanos , Material Particulado/análise , Vento
4.
J Environ Manage ; 302(Pt B): 114130, 2021 Nov 18.
Artigo em Inglês | MEDLINE | ID: mdl-34801868

RESUMO

Although soil fungi play a pivotal role in determining soil ecosystematic feedbacks to afforestation, there remains a big knowledge gap in the effects of afforestation on soil fungal communities, especially at a watershed scale. In this study, the variations of soil fungal diversity and community structures under afforestation were investigated in Nanliu River Basin, where paddy field and dry farmland were converted to eucalyptus plantation at an unprecedented speed. Spatial distance along the upper, middle and lower reaches of the Basin were also considered to analyze the dominant sources of the variations. The results demonstrated that eucalyptus afforestation had little effect on soil fungal diversity but could significantly influence fungal community structures. As paddy field and dry farmland converted to eucalyptus plantation, dominant fungal phylum shifted from Ascomycota to Ascomycota and Basidiomycota. Compared with afforestation from dry farmland, much bigger variation of fungal community structures was found in afforestation from paddy field. In addition, the significant change of fungal community structures exhibited in the upper reaches was from dry farmland, while presented in the middle reaches was from paddy field. However, afforestation comprised a larger source of variation than spatial distance within the soil fungal community structures, and Fusarium, Westerdykella,Zopfiella and Scleroderma were the most sensitive genera affected by afforestation. These results showed that afforestation did not always cause soil fungal diversity change and the heterogeneity of fungal community structures under afforestation was mainly controlled by original land use practices, while spatial distance partly decided the results.

5.
Zhongguo Gu Shang ; 34(11): 1040-3, 2021 Jul 25.
Artigo em Chinês | MEDLINE | ID: mdl-34812022

RESUMO

OBJECTIVE: To investigate the method and clinical effects of modified anchor insertion with single-row suture arthroscopic rotator cuff repair for aged patients with rotator cuff tear. METHODS: From March 2016 to February 2020, 96 aged patients with rotator cuff tears were retrospectively analyzed, including 29 males and 67 females, aged from 65 to 85 years, with a mean of (68.8±3.9) years. Patients were treated with modified anchor insertion with single-row suture arthroscopic rotator cuff repair technique. Before and after operation, University of California Los Angeles (UCLA) score, American Shoulder and Elbow Surgeons (ASES) score were used to evaluate shoulder joint function, visual analogue scale (VAS)was used to evaluate patients' pain. Among them, 32 patients underwent magnetic resonance examination one year postoperatively. RESULTS: All operations were completed and the patients were followed up from 11 to 42 months, with a mean of (21.4±7.5) months. The UCLA score increased from preoperative 12.22±3.30 to final follow-up 31.30±2.49 (t=45.21, P<0.01);ASES score increased from preoperative 8.60±1.88 to final follow-up 12.60±0.84 (t=19.05, P<0.01);and the VAS decreased from preoperative 5.00 (2.00 to 8.00)scores to final follow-up 1.00 (0.00 to 3.00)scores (Z=-12.22, P<0.05). One year after operation, one of the 32 patients who underwent MRI showed that the repaired rotator cuff was torn again, but it did not affect the normal life and did not operate again. During the final follow-up, no anchor extraction was found in all 96 aged patients. CONCLUSION: Modified anchor insertion with single-row suture arthroscopic rotator cuff repair technique for rotator cuff tear in aged patients could achieve satisfactory results and effectively reduce the anchor extraction rate.

6.
Comput Intell Neurosci ; 2021: 7149631, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34733325

RESUMO

The rationalization of human resource management is helpful for enterprises to efficiently train talents in the field, improve the management mode, and increase the overall resource utilization rate of enterprises. The current computational models applied in the field of human resources are usually based on statistical computation, which can no longer meet the processing needs of massive data and do not take into account the hidden characteristics of data, which can easily lead to the problem of information scarcity. The paper combines recurrent convolutional neural network and traditional human resource allocation algorithm and designs a double recurrent neural network job matching recommendation algorithm applicable to the human resource field, which can improve the traditional algorithm data training quality problem. In the experimental part of the algorithm, the arithmetic F1 value in the paper is 0.823, which is 20.1% and 7.4% higher than the other two algorithms, respectively, indicating that the algorithm can improve the hidden layer features of the data and then improve the training quality of the data and improve the job matching and recommendation accuracy.


Assuntos
Algoritmos , Redes Neurais de Computação , Simulação por Computador , Humanos , Alocação de Recursos , Recursos Humanos
7.
Cancer Manag Res ; 13: 8077-8084, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34737636

RESUMO

Objective: To explore the influence of trastuzumab (TZ) combined with docetaxel (DTX) on serum tumor markers (TMs) in the treatment of human epidermal growth factor receptor 2-positive (HER-2+) breast cancer (BC) and to analyze the factors influencing therapeutic efficacy. Methods: Ninety-six patients with HER-2+ BC treated in the First Affiliated Hospital of Anhui University Of Science and Technology from January 2019 to December 2020 were selected. According to different treatment plans, the patients were divided into two arms with 48 cases each. The control group (CG) was treated with DTX, and the research group (RG) was given TZ combined with DTX (TZ+DTX). The two arms were compared regarding the following aspects: curative effects, adverse reaction, alterations of TMs and inflammatory factors (IFs), and quality of life. Logistic regression analysis was performed to analyze the factors affecting the efficacy of patients. Results: After treatment, the TMs carcinoembryonic antigen (CEA), carbohydrate antigen (CA)125 and CA15-3 were significantly lower in RG compared with CG. The levels of IFs C-reactive protein (CRP) and tumor necrosis factor-α (TNF-α) were also lower in CG. The overall response rate and the Karnofsky performance status (KPS) score were significantly higher in RG. No evident difference was observed in the total incidence of adverse reactions between the two arms. The high expression of CEA, CA125 and CA15-3 as well as DTX monotherapy increased the risk of adverse prognosis. Conclusion: TZ+DTX can effectively improve the clinical efficacy of HER-2+ BC patients and reduce their levels of serum TMs and IFs.

8.
J Int Med Res ; 49(11): 3000605211055387, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34738481

RESUMO

Pulmonary large cell neuroendocrine carcinoma (LCNEC), which accounts for approximately 1% of all lung cancers, is a rare and highly aggressive malignancy with a poor prognosis. Therefore, it is important to devise an effective treatment strategy. In the treatment of locally advanced complex LCNEC, it is unique to first administer radiotherapy combined with albumin-bound paclitaxel plus carboplatin, followed by durvalumab for immune maintenance treatment after concurrent radiotherapy and chemotherapy to achieve complete remission. We report a 54-year-old man who smoked and who felt chest tightness for 2 weeks and was diagnosed as having combined pulmonary LCNEC. For patients with locally advanced pulmonary LCNEC, chemoradiotherapy increases overall survival. After surgical resection and chemoradiotherapy, our patient achieved complete remission. Durvalumab was then started to consolidate the treatment. After six courses of immune maintenance therapy, the patient developed grade 2 immune-related pneumonitis and took prednisone orally until the symptoms resolved, and then reached complete remission again. The patient achieved complete remission, which was a challenge with this rare carcinoma, through albumin-bound paclitaxel plus platinum-based chemotherapy combined with radiotherapy and durvalumab for immune maintenance therapy. This approach may provide a treatment option for locally advanced combined pulmonary LCNEC.


Assuntos
Carcinoma de Células Grandes , Carcinoma Neuroendócrino , Neoplasias Pulmonares , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Carboplatina/uso terapêutico , Carcinoma de Células Grandes/tratamento farmacológico , Carcinoma Neuroendócrino/tratamento farmacológico , Quimiorradioterapia , Humanos , Neoplasias Pulmonares/tratamento farmacológico , Masculino , Pessoa de Meia-Idade
9.
Oxid Med Cell Longev ; 2021: 3259963, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34603595

RESUMO

The normal function of the mitochondria is crucial for most tissues especially for those that demand a high energy supply. Emerging evidence has pointed out that healthy mitochondrial function is closely associated with normal heart function. When these processes fail to repair the damaged mitochondria, cells initiate a removal process referred to as mitophagy to clear away defective mitochondria. In cardiomyocytes, mitophagy is closely associated with metabolic activity, cell differentiation, apoptosis, and other physiological processes involved in major phenotypic alterations. Mitophagy alterations may contribute to detrimental or beneficial effects in a multitude of cardiac diseases, indicating potential clinical insights after a close understanding of the mechanisms. Here, we discuss the current opinions of mitophagy in the progression of cardiac diseases, such as ischemic heart disease, diabetic cardiomyopathy, cardiac hypertrophy, heart failure, and arrhythmia, and focus on the key molecules and related pathways involved in the regulation of mitophagy. We also discuss recently reported approaches targeting mitophagy in the therapy of cardiac diseases.

10.
Int J Gen Med ; 14: 6251-6259, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34629891

RESUMO

Introduction: Langerhans cell histiocytosis (LCH) is a histiocytic proliferative disease without a well-understood etiology. The aim of our study is to summarize the imaging features of PET/MR in children with LCH and to explore its diagnostic role in LCH. Methods: Retrospective analysis was performed of the pretreatment PET/MR imaging data of 15 children with LCH. Comparison of ADC values was done between lesions and normal tissues. Results: Of the fifteen patients enrolled, five had single-organ or single-system involvement, and ten had multiple-system involvement. Nine patients had varying degrees of bone destruction and increased FDG uptake, whereas thickening and deviation of the pituitary stalk and disappearance of the normal high-signal intensity of T1WI in the neurohypophysis were observed in the pituitary gland in six of them. Splenomegaly with diffuse increased FDG uptake or a normal spleen with increased FDG uptake was found in four cases, liver in three, multiple lymph node enlargement in three, pulmonary lesions in three, and increased metabolism in medullary cavity in two cases. Additionally, two cases involved the skin. Hypermetabolic nodules were detected in muscle in one case, thyroid involvement in one case, and a mediastinal lesion in one case. Conclusion: PET/MR can show well the distribution of the organs, systems, and lesions involved in LCH and is of considerable significance in the systemic evaluation of LCH.

11.
Front Med (Lausanne) ; 8: 678424, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34650991

RESUMO

Background: While infliximab has revolutionized the treatment of ulcerative colitis, primary non-response is difficult to predict, which limits effective disease management. The study aimed to establish a novel genetic model to predict primary non-response to infliximab in patients with ulcerative colitis. Methods: Publicly available mucosal expression profiles of infliximab-treated ulcerative colitis patients (GSE16879, GSE12251) were utilized to identify potential predictive gene panels. The random forest algorithm and artificial neural network were applied to further screen for predictive signatures and establish a model to predict primary non-response to infliximab. Results: A total of 28 downregulated and 2 upregulated differentially expressed genes were identified as predictors. The novel model was successfully established on the basis of the molecular prognostic score system, with a significantly predictive value (AUC = 0.93), and was validated with an independent dataset GSE23597 (AUC = 0.81). Conclusion: Machine learning was used to construct a predictive model based on the molecular prognostic score system. The novel model can predict primary non-response to infliximab in patients with ulcerative colitis, which aids in clinical-decision making.

12.
Sci Rep ; 11(1): 20468, 2021 Oct 14.
Artigo em Inglês | MEDLINE | ID: mdl-34650116

RESUMO

Previous studies have shown that ticagrelor reduced risk of pneumonia in patients with acute coronary syndrome (ACS) compared to clopidogrel, however, its effect in patients with non-ACS cardiovascular diseases remains uncertain. The aim was to investigate the effect of ticagrelor on pneumonia and pneumonia-specific death compared to clopidogrel in non-ACS patients in Hong Kong. This was a population-based cohort study. We included consecutive patients using ticagrelor or clopidogrel admitted for non-ACS conditions in Hong Kong public hospitals from March 2012 to September 2019. Patients using both drugs were excluded. The outcomes of interest were incident pneumonia, all-cause death, and pneumonia-specific death. Multivariable survival analysis models were used to estimate the effects [hazard ratio (HR) and 95% confidence interval (CI)]. Propensity score matching, adjustment and weighting were performed as sensitivity analyses. In total, 90,154 patients were included (mean age 70.66 years, males 61.7%). The majority of them (97.2%) used clopidogrel. Ticagrelor was associated with a lower risk of incident pneumonia [0.59 (0.46-0.75)], all-cause death [0.83 (0.73-0.93)] and pneumonia-specific death [0.49 (0.36-0.67)]. Sensitivity analyses yielded similar results. Ticagrelor was associated with lower risk of all-cause death, pneumonia-specific death, and incident pneumonia in patients with non-ACS cardiovascular conditions, consistent with previous evidence in patients with ACS. This additional effect of anti-pneumonia should be considered when choosing a proper P2Y12 inhibitor for patients with high risk of pneumonia.

13.
Nutr Metab Cardiovasc Dis ; 31(12): 3335-3344, 2021 Nov 29.
Artigo em Inglês | MEDLINE | ID: mdl-34629246

RESUMO

BACKGROUND AND AIMS: Recent research demonstrated that obesity and high dietary sodium intake, the two established risk factors for hypertension, were associated with each other. The objective was to investigate the potential indirect effect of sodium intake on blood pressure via body mass index (BMI). METHODS AND RESULTS: Using ten years data from US NHANES (2007-2016), the study included adult participants (>20 years old) who were not taking antihypertensive medications and without baseline diseases (n = 12,262). BMI was modelled as the mediator of sodium intake on systolic and diastolic blood pressure, adjusted for age, sex, socioeconomic status, smoking, drinking, physical activity, calorie intake, fluid intake and potassium intake. Mediation analysis was performed to evaluate total effect, direct effect and indirect effect via BMI. Subgroup analyses based on three age subgroups (20-40, 41-60 and ≥61 years old) were performed. The mean age was 39.29 (13.4) years and 53.1 (0.45) % were males. The mean BMI was 27.8 (6.20) kg/m2. Overall, 1 g/d increase in sodium intake was associated with an increased systolic blood pressure by 0.36 (95% confidence interval 0.14 to 0.58) mmHg, with a direct effect (0.14 (0.09-0.19)) and an indirect effect via BMI (0.23 (0.02-0.44)). The indirect effect was mainly observed in participants ≤60 years old. CONCLUSION: Sodium intake showed both direct effect and indirect effect (via BMI) on systolic blood pressure in US NHANES. The findings provide evidence for combining sodium restriction and weight reduction measures for prevention of hypertension. Cautions should be taken when generalizing the findings to other populations with lower average BMI.

14.
Pharmacol Res ; 174: 105955, 2021 Oct 29.
Artigo em Inglês | MEDLINE | ID: mdl-34715330

RESUMO

Severe Coronavirus Disease 2019 (COVID-19) is characterized by numerous complications, complex disease, and high mortality, making its treatment a top priority in the treatment of COVID-19. Integrated traditional Chinese medicine (TCM) and western medicine played an important role in the prevention, treatment, and rehabilitation of COVID-19 during the epidemic. However, currently there are no evidence-based guidelines for the integrated treatment of severe COVID-19 with TCM and western medicine. Therefore, it is important to develop an evidence-based guideline on the treatment of severe COVID-19 with integrated TCM and western medicine, in order to provide clinical guidance and decision basis for healthcare professionals, public health personnel, and scientific researchers involved in the diagnosis, treatment, and care of COVID-19 patients. We developed and completed the guideline by referring to the standardization process of the "WHO handbook for guideline development", the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system, and the Reporting Items for Practice Guidelines in Healthcare (RIGHT).

15.
Zhongguo Gu Shang ; 34(9): 826-9, 2021 Sep 25.
Artigo em Chinês | MEDLINE | ID: mdl-34569206

RESUMO

OBJECTIVE: To compare clinical efficacy of intramedullary nail fixation following two-step closed reduction or limited open reduction for femoral subtrochanteric fractures. METHODS: Forty six patients with femoral subtrochanteric fractures were analyzed retrospectively from January 2014 to April 2020. Twenty four patients which including 16 males and 8 females, aged from 34 to 91 years old with an average of (55.42±18.25) years old, were treated with two step closed reduction and intramedullary nail fixation on supine position. Twenty-two patients which including 15 males and 7 females, aged from 33 to 87 years old with an average of (56.31±14.77) years old, were performed limited open reductionand intramedullary nail fixation. Operation time, intraoperative blood loss, complications and fracture healing time were recorded and compared between two groups. Postoperative Harris hip score at 8 months was applied to evalaute joint function. RESULTS: All patients were successfully complete operation without incision infection. All patients were followed up from 8 to 36 months with an average of (18.2± 6.1) months. Introperation blood loss, operation time in closed reduction group were (157.92±51.07) ml, (82.08±13.43) min respectively, while in limited open reduction group were (230.91±87.88) ml, (92.73±12.79) min respectively; while there were statistical difference between two groups (P<0.05). There was no difference in fracture healing time between two groups (P>0.05). There were 2 patients in each groups occurred pulmonary infection and healed after medical treatment. No statistical difference in postoperative Harris score at 8 months between closed reduction group (88.42±6.85) and limited open reduction group (88.55±6.31)(P>0.05). CONCLUSION: Femoral subtrochanteric fractures could be effectively treated by both methods. Two-step closed reduction and intramedullary nail fixation may be more advantageous in less tissue damage, shorter operation time and less intraoperative bleeding.


Assuntos
Fraturas do Fêmur , Fixação Intramedular de Fraturas , Fraturas do Quadril , Adulto , Idoso , Idoso de 80 Anos ou mais , Pinos Ortopédicos , Feminino , Consolidação da Fratura , Fraturas do Quadril/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Resultado do Tratamento
17.
Sci Total Environ ; 806(Pt 2): 150599, 2021 Sep 27.
Artigo em Inglês | MEDLINE | ID: mdl-34592278

RESUMO

In salt-affected and groundwater-fed oasis-desert systems, water and salt balance is critically important for stable coexistence of oasis-desert ecosystems, especially in the context of anthropogenic-induced over-development and perturbations due to climate variability that affects the sustainability of human-natural systems. Here, an investigation of the spatio-temporal variability of soil salinity and groundwater dynamics across four different hydrological regions in oasis-desert system is performed. An evaluation of the effects of soil salinization and groundwater degradation interplays on the coexistence of oasis-desert ecosystems in northwestern China is undertaken over 1995-2020, utilizing comprehensive measurements and ecohydrological modelling framework. We note that the process of salt migration and accumulation across different landscapes in oasis-desert system is reshaping, with soil salinization accelerating especially in water-saving agricultural irrigated lands. The continuous decline in groundwater tables, dramatic shifts in groundwater flow patterns and significant degradation of groundwater quality are occurring throughout the watershed. Worse so, a clear temporal-spatial relationship between soil salinization and groundwater degradation appearing to exacerbate the regional water-salt imbalance. Also, the eco-environmental flows are reaching to their limit with watershed closures, although these progressions were largely hidden by regional precipitation and streamflow variability. The oasis-desert ecosystems tend to display bistable dynamics with two preferential configurations of bare and vegetated soils, and soil salinization and groundwater degradation interplays are causing catastrophic shift in the oasis-desert ecosystems. The results highlight the importance of regional adaptive water and salt management to maintain the coexistence of oasis-desert ecosystems in arid areas.

18.
ACS Biomater Sci Eng ; 7(10): 4971-4981, 2021 10 11.
Artigo em Inglês | MEDLINE | ID: mdl-34503336

RESUMO

Simulating the structure and function of blood capillaries is very important for an in-depth insight into their role in the human body and treatment of capillary-related diseases. Due to the similar composition and structure, hollow hydrogel microfibers are well-recognized as potential biomimetic blood capillaries. In this paper, we report a novel, facile, and reproducible method to fabricate coaxial microfluidic chips via 3D printing-assisted soft lithography and then hollow hydrogel microfibers using the as-prepared coaxial microfluidic chips. Instead of traditional photoresist-based lithography, 3D printing of gelatin hydrogel under various extrusion pressures is used to construct sacrificial templates of coaxial microfluidic chips. Various solid and hollow hydrogel microfibers with complicated and hierarchical structures can be obtained via multitype coaxial microfluidic chips or a combination of coaxial microfluidic fabrication and post-treatment. The as-formed hollow hydrogel microfibers are evaluated in detail as biomimetic blood capillaries, including physicochemical and cytological properties. Our results prove that the hollow hydrogel microfibers exhibit excellent mass transport capacity, hemocompatibility, semipermeability, and mechanical strength, and their barrier function can be further enhanced in the presence of endothelial cells. Overall, our 3D printing-assisted fabrication strategy provides a new technique to construct microfluidic chips with complicated 3D microchannels, and the resulting hollow hydrogel microfibers are promising candidates for blood capillaries.


Assuntos
Hidrogéis , Microfluídica , Biomimética , Capilares , Células Endoteliais , Humanos , Impressão Tridimensional , Engenharia Tecidual
19.
Nat Commun ; 12(1): 5189, 2021 08 31.
Artigo em Inglês | MEDLINE | ID: mdl-34465768

RESUMO

Using Epstein-Barr virus (EBV)-based markers to screen populations at high risk for nasopharyngeal carcinoma (NPC) is an attractive preventive approach. Here, we develop a comprehensive risk score (CRS) that combines risk effects of EBV and human genetics for NPC risk stratification and validate this CRS within an independent, population-based dataset. Comparing the top decile with the bottom quintile of CRSs, the odds ratio of developing NPC is 21 (95% confidence interval: 12-37) in the validation dataset. When combining the top quintile of CRS with EBV serology tests currently used for NPC screening in southern China, the positive prediction value of screening increases from 4.70% (serology test alone) to 43.24% (CRS plus serology test). By identifying individuals at a monogenic level of NPC risk, this CRS approach provides opportunities for personalized risk prediction and population screening in endemic areas for the early diagnosis and secondary prevention of NPC.


Assuntos
Infecções por Vírus Epstein-Barr/genética , Carcinoma Nasofaríngeo/genética , Neoplasias Nasofaríngeas/genética , Adulto , Idoso , Anticorpos Antivirais/sangue , China , Detecção Precoce de Câncer , Infecções por Vírus Epstein-Barr/sangue , Infecções por Vírus Epstein-Barr/diagnóstico , Infecções por Vírus Epstein-Barr/virologia , Feminino , Genótipo , Herpesvirus Humano 4/genética , Herpesvirus Humano 4/imunologia , Herpesvirus Humano 4/isolamento & purificação , Humanos , Masculino , Pessoa de Meia-Idade , Carcinoma Nasofaríngeo/sangue , Carcinoma Nasofaríngeo/diagnóstico , Carcinoma Nasofaríngeo/virologia , Neoplasias Nasofaríngeas/sangue , Neoplasias Nasofaríngeas/diagnóstico , Neoplasias Nasofaríngeas/virologia , Polimorfismo de Nucleotídeo Único , Medição de Risco , Fatores de Risco
20.
Hepatology ; 2021 Sep 12.
Artigo em Inglês | MEDLINE | ID: mdl-34510514

RESUMO

Globally, NAFLD is one of the most common liver disorders, with an estimated prevalence rate of more than 30% in men and 15% in women, and an even higher prevalence in people with type 2 diabetes mellitus. Optimal pharmacologic therapeutic approaches for NAFLD are an urgent necessity. In this study, we showed that compared to healthy controls, hepatic ACSL4 levels in NAFLD patients were found to be elevated. Suppression of ACSL4 expression promoted mitochondrial respiration, thereby enhancing the capacity of hepatocytes to mediate ß-oxidation of fatty acids and to minimize lipid accumulation by up-regulating PGC1α. Moreover, we found that abemaciclib is a potent and selective ACSL4 inhibitor, low-dose of abemaciclib significantly ameliorated most of the NAFLD symptoms in multiple NAFLD mice models. Therefore, inhibition of ACSL4 is a potential alternative therapeutic approach for NAFLD.

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