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Sci Rep ; 10(1): 4149, 2020 03 05.
Artigo em Inglês | MEDLINE | ID: mdl-32139743


Following recent tsunamis, most studies have focused on the onshore deposits, while the offshore backwash deposits, crucial for a better understanding of the hydrodynamic processes during such events and offering an opportunity for sedimentary archives of past tsunamis, have mostly been omitted. Here, we present a unique sedimentary record of the backwash from two historical tsunamis sampled in a sheltered bay in American Samoa, namely the 2009 South Pacific Tsunami and the 1960 Great Chilean Earthquake Tsunami. Although not always concomitant with a marked grain size change, backwash deposits are identified by terrestrial geochemical and mineralogical signatures, associated with basal soft sediment micro-deformations. These micro-deformations, including asymmetric flame structures, are described for the first time in historic shallow marine backwash deposits and lead us to propose an improved depositional mechanism for tsunami backflow based on hyperpycnal currents. Moreover, this study brings a potential new criterion to the proxy toolkit for identifying tsunami backwash deposits, namely the basal soft sediment micro-deformations. We suggest that further studies focus on these micro-deformations in order to test the representability of this criterion for tsunami backwash deposits. Sheltered shallow marine environments in areas repeatedly impacted by tsunamis have a higher potential for the reconstruction of paleo-tsunami catalogs and should be preferentially investigated for coastal risk assessment.

BMC Anesthesiol ; 17(1): 171, 2017 Dec 19.
Artigo em Inglês | MEDLINE | ID: mdl-29258432


BACKGROUND: This pilot study was designed to compare the efficacy of ultramicronized palmitoylethanolamide (um-PEA) as add-on therapy to tapentadol (TP) with TP therapy only in patients suffering from chronic low back pain (LBP). METHODS: This pilot observational study consists in two arms: the prospective arm and the retrospective one. In the prospective arm patients consecutively selected received um-PEA as add-on therapy to TP for 6 months; in the retrospective arm patients were treated with TP only for 6 months. Pain intensity and neuropathic component were evaluated at baseline, during and after 6 months. The degree of disability and TP dosage assumption were evaluated at baseline and after 6 months. RESULTS: Statistical analysis performed with generalized linear mixed model on 55 patients (30 in the prospective group and 25 in the retrospective group) demonstrated that um-PEA as add-on treatment to TP in patients with chronic LBP, in comparison to TP alone, led to a significantly higher reduction in pain intensity, in the neuropathic component, the degree of disability and TP dosage assumption. No serious side effects were observed. CONCLUSION: Overall, the present findings suggest that um-PEA may be an innovative therapeutic intervention as add-on therapy to TP for the management of chronic LBP with a neuropathic component, as well as to improve patient quality of life. Additionally, this combination treatment allowed a reduction in TP dose over time and did not show any serious side effects.

Analgésicos/administração & dosagem , Etanolaminas/administração & dosagem , Dor Lombar/diagnóstico , Dor Lombar/tratamento farmacológico , Ácidos Palmíticos/administração & dosagem , Fenóis/administração & dosagem , Idoso , Amidas , Relação Dose-Resposta a Droga , Composição de Medicamentos , Quimioterapia Combinada , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Projetos Piloto , Estudos Prospectivos , Estudos Retrospectivos , Tapentadol , Resultado do Tratamento
J Environ Radioact ; 178-179: 411-418, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-28689881


The National Health and Medical Research Council and Natural Resource Management Ministerial Council of Australia developed the current Australian Drinking Water Guidelines which recommend an annual radiation dose value of 1 mSv year-1. One of the potential major contributors to the radiation dose from drinking water is radium-228, a naturally occurring radionuclide arising from the thorium decay series. Various methods of analysing for radium-228 in water have been established and adapted by analytical radiochemistry laboratories. Seven laboratories in Australia participated in analysing radium-228 spiked water samples with activity concentrations ranging from 6 mBq L-1 to 20 Bq L-1. The aim of the exercise was to compare and evaluate radium-228 results reported by the participating laboratories, the methods used and the detection limits. This paper presents the outcome of the exercise.

Laboratórios/estatística & dados numéricos , Monitoramento de Radiação , Rádio (Elemento)/análise , Poluentes Radioativos da Água/análise , Austrália