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1.
Curr Pharm Des ; 2020 Apr 17.
Artigo em Inglês | MEDLINE | ID: mdl-32303161

RESUMO

Nonalcoholic fatty liver disease (NAFLD) embraces histopathological entities ranging from the relatively benign simple steatosis to the progressive form nonalcoholic steatohepatitis (NASH), which is associated with fibrosis and an increased risk of progression to cirrhosis and hepatocellur carcinoma. NAFLD is the most common liver disease and is associated with extrahepatic comorbidities including a major cardiovascular disease burden. The non-invasive diagnosis of NAFLD and the identification of subjects at risk of progressive liver disease and cardio-metabolic complications are key in implementing personalized treatment schedules and follow-up strategies. In this review we highlight the potential role of ultrasound semiquantitative scores for detecting and assessing steatosis severity, progression of NAFLD and cardio-metabolic risk. Ultrasonographic scores of fatty liver severity act as sensors of cardio-metabolic health and may assist in selecting patients to submit to second-line non-invasive imaging techniques and/or liver biopsy.

2.
Adv Ther ; 37(5): 1910-1932, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32285340

RESUMO

Atrial fibrillation (AF) and venous thromboembolism (VTE) are highly prevalent and relevant healthcare issues. Direct oral anticoagulants (DOACs) are now the first-choice for anticoagulant treatment of these conditions displaying a better efficacy/safety profile than vitamin-K antagonists, mainly due to significantly reduced risk of major bleeding, especially of intracranial haemorrhage. Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in developed countries showing a continuously growing prevalence. Nonalcoholic steatohepatitis (NASH), its evolutive form, will be the leading cause for liver transplantation by 2020. NAFLD is independently associated with an increased risk of abnormalities of cardiac structure and function, including cardiac rhythm disorders (mainly AF). Moreover, data suggest an increased risk of unprovoked VTE associated with NAFLD/NASH. Therefore, a growing number of patients with chronic liver disease (CLD) will be candidate for anticoagulant therapy in the near future. Cirrhosis of any etiology is characterized by an unstable thrombosis/bleeding haemostatic balance, making anticoagulant therapy particularly challenging in this condition. Given that patients with significant active liver disease and cirrhosis were excluded from all pivotal randomized controlled trials on DOACs, this comprehensive review aims at critically discussing real-world evidence, including the latest population studies, regarding the use of DOACs in patients with CLD/cirrhosis.

3.
Vet Ital ; 54(2): 175-180, 2018 Jun 30.
Artigo em Inglês | MEDLINE | ID: mdl-30019334

RESUMO

The present case study concerns a case of predation of 4 individuals of captive pink flamingo in Emilia Romagna Region, Northeastern Italy. The pink flamingo (Phoenicopterus roseus) is a species included in the Red List of Threatened Species established by the International Union for Conservation of Nature (IUCN) which lists species in danger of extinction. During the Winter of 2013, 4 flamingos (2 in the Comacchio area, and 2 from Argenta and Codigoro oases - Ferrara province) were found dead some of them headless, with their bodies severely bitten. At first, a fox (Vulpes vulpes) was suspected to be the predator responsible for the killing and the birds were taken to the laboratory for further investigations. The investigations included: field observations, study of the predator behaviour, necropsy examinations, assessment of the intercanine distance, and genetic analysis on the predator's traces. The intercanine distance indicated that the predator could not have been a fox. The analysis of salivary DNA samples enabled us to establish that the predator was in fact a dog. This case highlights the importance of co-operation among the various branches of forensic sciences and the great usefulness of the roles filled by other veterinary forensic experts involved in solving crime.


Assuntos
Aves/lesões , Mordeduras e Picadas/patologia , Cães , Espécies em Perigo de Extinção , Animais , Ciências Forenses , Itália , Comportamento Predatório , Medicina Veterinária
4.
J Wildl Dis ; 49(4): 1042-6, 2013 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-24502738

RESUMO

Over a 7-day period beginning 8 August 2011, a large number of wild birds of several species were found dead or with neurologic clinical signs along the shore of Crostolo stream, in the Emilia Romagna region, Italy. Twenty-eight Mallards (Anas platyrhynchos), two Hooded Crows (Corvus corone cornix), and three coypus (Myocastor coypus) were found moribund on the Crostolo stream bank, collected, and sent to Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna, Reggio Emilia Section. The cause of mortality was determined to be Clostridium botulinum type C toxin. The toxin was identified by a mouse bioassay for botulinum toxins and confirmed in bird sera and blowfly larvae (Lucilia caesar) collected from the stomachs of birds.


Assuntos
Aves , Toxinas Botulínicas/toxicidade , Botulismo/veterinária , Surtos de Doenças/veterinária , Mamíferos , Animais , Botulismo/epidemiologia , Itália/epidemiologia
5.
Vet Parasitol ; 178(3-4): 370-3, 2011 Jun 10.
Artigo em Inglês | MEDLINE | ID: mdl-21296503

RESUMO

Trichinella pseudospiralis is a non-encapsulated species infecting both mammals and birds. In Italy, this parasite was reported only in two night-birds of prey of Central Italy. In January 2010, Trichinella larvae were detected in three wild boars (Sus scrofa) of two regions of Northern Italy by enzymatic digestion. The parasites were identified as T. pseudospiralis by multiplex-PCR. The first infected wild boar was hunted in the Emilia Romagna region and the other two infected wild boars were bred outdoors in a small family farm of the Friuli Venezia Giulia region. These new epidemiological data reinforce the role of the wild boar as the main reservoir of T. pseudospiralis in Europe.


Assuntos
Diafragma/parasitologia , Sus scrofa , Doenças dos Suínos/parasitologia , Trichinella/isolamento & purificação , Triquinelose/veterinária , Animais , Anticorpos Anti-Helmínticos/sangue , Ensaio de Imunoadsorção Enzimática/veterinária , Itália , Suínos , Triquinelose/parasitologia
6.
Res Vet Sci ; 91(2): 243-5, 2011 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-21310448

RESUMO

A new quantitative real-time PCR (qPCR) assay based on Taqman® technology and minor groove binding (MGB) probe was developed for the diagnosis of leishmaniosis and quantification of Leishmania infantum DNA in infected dogs. This method was based on the amplification of a 122bp fragment of the highly conserved kDNA minicircles of L. infantum. The reaction was performed using the StepOnePlus™ system with StepOne software™. This assay was able to detect the presence of protozoan parasite DNA in amounts as low as 0.03 parasites per reaction. The standard curve designed for the quantification of parasites showed linearity over seven log DNA concentration range with a correlation coefficient >0.999 and both intra- and inter-assay variability demonstrated the high efficiency and reproducibility of the assay. The qPCR also proved to be successfully applicable to different clinical samples including blood, bone marrow, lymph node aspirates and conjunctival swabs.


Assuntos
DNA de Cinetoplasto/análise , Doenças do Cão/diagnóstico , Leishmania infantum/isolamento & purificação , Leishmaniose/veterinária , Reação em Cadeia da Polimerase em Tempo Real/métodos , Animais , Medula Óssea/parasitologia , Túnica Conjuntiva/parasitologia , DNA de Cinetoplasto/sangue , DNA de Cinetoplasto/genética , Doenças do Cão/parasitologia , Cães , Leishmania infantum/genética , Leishmaniose/diagnóstico , Leishmaniose/parasitologia , Linfonodos/parasitologia , Reação em Cadeia da Polimerase em Tempo Real/veterinária , Reprodutibilidade dos Testes , Sensibilidade e Especificidade
7.
Psicol. rev ; (1): 69-78, set. 1995.
Artigo em Português | Index Psicologia - Periódicos técnico-científicos | ID: psi-18759

RESUMO

Devemos a Kretschmer o conceito de diagnóstico pluridimensional em psiquiatria. Entre nós, um dos que mais estudou o assunto foi Leme Lopes. Sem alterar a idéia básica de diagnóstico pluridimensional dinâmico, propomos um novo esquema, inspirado nas séries complementares de Freud. Mostram a vantagem e a clareza do novo esquema para uma visão holística dos pacientes (AU)

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