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1.
Polymers (Basel) ; 12(5)2020 May 13.
Artigo em Inglês | MEDLINE | ID: mdl-32413965

RESUMO

Metal organic frameworks (MOFs) are porous crystalline materials that can be designed to act as selective adsorbents. Due to their high porosity they can possess very high adsorption capacities. However, overcoming the brittleness of these crystalline materials is a challenge for many industrial applications. In order to make use of MOFs for large-scale liquid phase separation processes they can be immobilized on solid supports. For this purpose, nanocellulose can be considered as a promising supporting material due to its high flexibility and biocompatibility. In this study a novel flexible nanocellulose MOF composite material was synthesised in aqueous media by a novel and straightforward in situ one-pot green method. The material consisted of MOF particles of the type MIL-100(Fe) (from Material Institute de Lavoisier, containing Fe(III) 1,3,5-benzenetricarboxylate) immobilized onto bacterial cellulose (BC) nanofibers. The novel nanocomposite material was applied to efficiently separate arsenic and Rhodamine B from aqueous solution, achieving adsorption capacities of 4.81, and 2.77 mg g‒1, respectively. The adsorption process could be well modelled by the nonlinear pseudo-second-order fitting.

2.
Zootaxa ; 4603(2): zootaxa.4603.2.12, 2019 May 09.
Artigo em Inglês | MEDLINE | ID: mdl-31717236

RESUMO

The population of Mobula birostris ("giant manta ray") found in the waters of northern Peru and Ecuador is believed to be the largest in the world (Harding Beirwagen, 2009). This species is considered to be the largest within the group of manta rays, as they attains at least 670 cm disc width (reported to 910 cm) (White et al., 2006) and there is a record of an individual weighing 2000 kg (Kunjipalu Boopendranath, 1981). This species is ovoviviparous (matrotrophic viviparious) (Herbert, 2012). A single pup follows a gestation period of approximently one year, (Marshall et al., 2008, Mendonça et al., 2012). Sucessive pregnancies are speculated to be separated by a refactory period of two or more years (Mendonça et al., 2012). The objective of this study is to record the measurements of a M. birostris fetus of a female caught accidentally in the region of Tumbes, Peru. This is the first record of morphological and morphometric data regarding a manta fetus in Peru.


Assuntos
Elasmobrânquios , Rajidae , Animais , Equador , Feminino , Feto , Peru
3.
J Hazard Mater ; 364: 309-316, 2019 02 15.
Artigo em Inglês | MEDLINE | ID: mdl-30384240

RESUMO

The final repository for short-lived, low and intermediate level radioactive waste in Sweden is built to act as a passive repository. Already within a few years after closure water will penetrate the repository and conditions of high alkalinity (pH 10.5-13.5) and low temperature (< 7 °C) will prevail. The mobility of radionuclides in the repository is dependent on the radionuclides distribution between solid and liquid phases. In the present work the incorporation of strontium (II) and europium (III) in α-calcium isosaccharinate (ISA) under alkaline conditions (pH ∼10) at 5 °C and 50 °C have been studied. The results show that strontium and europium are incorporated into α-Ca(ISA)2 when crystallized both at 5 °C and 50 °C. Europium is incorporated to a greater extent than strontium. The highest incorporation of europium and strontium at 5 °C rendered the phase compositions Ca0.986Eu0.014(ISA)2 (2.4% of Eu(ISA)3 by mass) and Ca0.98Sr0.02(ISA)2 (2.2% of Sr(ISA)2 by mass). XPS spectra show that both trivalent and divalent Eu coexist in the Eu incorporated samples. Strontium ions were found to retard the elongated growth of the Ca(ISA)2 crystals. The incorporation of Sr2+ and Eu3+ into the solid phase of Ca(ISA)2 is expected to contribute to a decreased mobility of these ions in the repository.

4.
J Hazard Mater ; 340: 384-389, 2017 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-28735181

RESUMO

The deep repository for low and intermediate level radioactive waste SFR in Sweden will contain large amounts of cellulosic waste materials contaminated with radionuclides. Over time the repository will be filled with water and alkaline conditions will prevail. In the present study degradation of cellulosic materials and the ability of cellulosic degradation products to solubilize and thereby mobilise Eu(III) under repository conditions has been investigated. Further, the possible immobilization of Eu(III) by sorption onto cement in the presence of degradation products has been investigated. The cellulosic material has been degraded under anaerobic and aerobic conditions in alkaline media (pH: 12.5) at ambient temperature. The degradation was followed by measuring the total organic carbon (TOC) content in the aqueous phase as a function of time. After 173days of degradation the TOC content is highest in the anaerobic artificial cement pore water (1547mg/L). The degradation products are capable of solubilising Eu(III) and the total europium concentration in the aqueous phase was 900µmol/L after 498h contact time under anaerobic conditions. Further it is shown that Eu(III) is adsorbed to the hydrated cement to a low extent (<9µmol Eu/g of cement) in the presence of degradation products.

5.
Artigo em Inglês | MEDLINE | ID: mdl-27570649

RESUMO

With the development of platforms enabling the use of routinely collected clinical data in the context of international clinical research, scalable solutions for cross border semantic interoperability need to be developed. Within the context of the IMI EHR4CR project, we first defined the requirements and evaluation criteria of the EHR4CR semantic interoperability platform and then developed the semantic resources and supportive services and tooling to assist hospital sites in standardizing their data for allowing the execution of the project use cases. The experience gained from the evaluation of the EHR4CR platform accessing to semantically equivalent data elements across 11 European participating EHR systems from 5 countries demonstrated how far the mediation model and mapping efforts met the expected requirements of the project. Developers of semantic interoperability platforms are beginning to address a core set of requirements in order to reach the goal of developing cross border semantic integration of data.

6.
Dalton Trans ; 44(31): 14130-8, 2015 Aug 21.
Artigo em Inglês | MEDLINE | ID: mdl-26174497

RESUMO

We have reinvestigated the crystal structure of the low-dimensional fluoride ß-FeF3(H2O)2·H2O using high resolution neutron and X-ray diffraction data. Moreover we have studied the magnetic behavior of this material combining medium resolution and high flux neutron powder diffraction together with magnetic susceptibility measurements. This fluoride compound exhibits vertex-shared 1D Fe(3+) octahedral chains, which are extended along the c-axis. The magnetic interactions between adjacent chains involve super-superexchange interactions via an extensive network of hydrogen bonds. This interchain hydrogen bonding scheme is sufficiently strong to induce a long range magnetic order appearing below T = 20(1) K. The magnetic order is characterized by the propagation vector k = (0, 0, 1/2), giving rise to a strictly antiferromagnetic structure where the Fe(3+) spins are lying within the ab-plane. Magnetic exchange couplings extracted from magnetization measurements are found to be J∥/kb = -18 K and J⊥/kb = -3 K. These values are in good agreement with the neutron diffraction data, which show that the system became antiferromagnetically ordered at ca. TN = 20(1) K.

7.
Ther Innov Regul Sci ; 49(1): 116-125, 2015 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30222460

RESUMO

Although much information is already available publically from information-sharing initiatives such as ClinicalTrials.gov, information about clinical programs is unstructured, inconsistent, and incomplete. Clinical research within bioscience companies, health care, academia, and governmental agencies could benefit from easier access to best practices, historical information, and improved information sharing. Facilitating information sharing requires a standardized information model. Information standards today focus on individual clinical trials and the representation of clinical trial data. Although work is ongoing to expand standards to cover the protocol, these are insufficient to capture the objectives, rationale, and design thinking behind clinical programs. An information model is proposed to cover the rationalization and decision-making aspects of designing a clinical program and its associated trials. This paper is the output of a newly formed multicompany working group that examines the merits of a clinical program-level information standard. An example information model is presented to explain the concept.

8.
Stud Health Technol Inform ; 205: 594-8, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25160255

RESUMO

Use of medical terminologies and mappings across them are considered to be crucial pre-requisites for achieving interoperable eHealth applications. Built upon the outcomes of several research projects, we introduce a framework for evaluating and utilizing terminology mappings that offers a platform for i) performing various mappings strategies, ii) representing terminology mappings together with their provenance information, and iii) enabling terminology reasoning for inferring both new and erroneous mappings. We present the results of the introduced framework from SALUS project where we evaluated the quality of both existing and inferred terminology mappings among standard terminologies.


Assuntos
Algoritmos , Documentação/normas , Guias como Assunto , Processamento de Linguagem Natural , Garantia da Qualidade dos Cuidados de Saúde/métodos , Terminologia como Assunto , Vocabulário Controlado , Garantia da Qualidade dos Cuidados de Saúde/normas , Semântica
9.
Artigo em Inglês | MEDLINE | ID: mdl-25954572

RESUMO

Integration profiles collaboratively developed by CDISC and IHE for integrating data from Electronic Health Records (EHRs) with clinical research and pharmacovigilance are limited to resolving lexical/syntactic data integration issues and do not address semantic barriers. This paper describes the collaboration between two European projects - EHR4CR and SALUS - in implementing ISO/IEC 11179-based metadata registries (MDRs) and semantically integrated cross-platform data access. A common "semantic MDR" provides a framework for bidirectional/cross-MDR mapping and federated queries are enabled using the newly-defined IHE Data Exchange (DEX) profile. In the pilot implementation, mappings for 178 EHR4CR and 199 SALUS metadata elements were persisted in the semantic MDR. The DEX profile was then used to access semantically equivalent data elements in SALUS or EHR4CR participating EHR systems. ISO/IEC 11179-based MDRs and DEX integration profile address the goal of developing pan-EU computable semantic integration of data from clinical care, clinical research, and patient safety platforms.

10.
BMC Bioinformatics ; 8 Suppl 3: S2, 2007 May 09.
Artigo em Inglês | MEDLINE | ID: mdl-17493285

RESUMO

BACKGROUND: A fundamental goal of the U.S. National Institute of Health (NIH) "Roadmap" is to strengthen Translational Research, defined as the movement of discoveries in basic research to application at the clinical level. A significant barrier to translational research is the lack of uniformly structured data across related biomedical domains. The Semantic Web is an extension of the current Web that enables navigation and meaningful use of digital resources by automatic processes. It is based on common formats that support aggregation and integration of data drawn from diverse sources. A variety of technologies have been built on this foundation that, together, support identifying, representing, and reasoning across a wide range of biomedical data. The Semantic Web Health Care and Life Sciences Interest Group (HCLSIG), set up within the framework of the World Wide Web Consortium, was launched to explore the application of these technologies in a variety of areas. Subgroups focus on making biomedical data available in RDF, working with biomedical ontologies, prototyping clinical decision support systems, working on drug safety and efficacy communication, and supporting disease researchers navigating and annotating the large amount of potentially relevant literature. RESULTS: We present a scenario that shows the value of the information environment the Semantic Web can support for aiding neuroscience researchers. We then report on several projects by members of the HCLSIG, in the process illustrating the range of Semantic Web technologies that have applications in areas of biomedicine. CONCLUSION: Semantic Web technologies present both promise and challenges. Current tools and standards are already adequate to implement components of the bench-to-bedside vision. On the other hand, these technologies are young. Gaps in standards and implementations still exist and adoption is limited by typical problems with early technology, such as the need for a critical mass of practitioners and installed base, and growing pains as the technology is scaled up. Still, the potential of interoperable knowledge sources for biomedicine, at the scale of the World Wide Web, merits continued work.


Assuntos
Pesquisa Biomédica/métodos , Bases de Dados Factuais , Disseminação de Informação/métodos , Internet , Processamento de Linguagem Natural , Neurociências/métodos , Projetos de Pesquisa , Pesquisa Biomédica/organização & administração , Documentação/métodos , Armazenamento e Recuperação da Informação/métodos , Internacionalidade , Neurociências/organização & administração , Pesquisa/organização & administração , Semântica
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