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Aust Dent J ; 62(3): 386-389, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28466503


The objective of the present study was to report the case of a pregnant woman with severe gingival enlargement for 3 months with undiagnosed acute leukaemia. The pregnant woman presented with anaemia and generalized gingival enlargement. A provisional diagnosis of gingival enlargement in pregnancy was made. Twelve days after the initial treatment, the patient was referred and admitted to the haematology department of a local hospital with clinical signs of anaemia and thrombocytopenia. Blood count showed a white blood cell count of 9.68 × 109 /L, with a haemoglobin count of 64.0 g/L and a platelet count of 17 × 109 /L. Bone marrow aspiration showed 94.5% monoblasts, and the morphological diagnosis was acute monocytic leukaemia. One day after admission, the patient delivered a male infant by Caesarean section. Ten days after the Caesarean section, the patient was started on a course of chemotherapy. Pulmonary infection, hypokalaemia, and respiratory failure developed, and the patient died 23 days after the Caesarean section. The present case shows the importance of awareness of severe gingival enlargement as an initial oral sign of acute leukaemia.

Hiperplasia Gengival/diagnóstico , Leucemia Monocítica Aguda/diagnóstico , Complicações Neoplásicas na Gravidez , Adulto , Antineoplásicos/uso terapêutico , Evolução Fatal , Feminino , Humanos , Recém-Nascido , Leucemia Monocítica Aguda/tratamento farmacológico , Masculino , Gravidez , Resultado da Gravidez
Clin. transl. oncol. (Print) ; 17(1): 41-49, ene. 2015. tab, ilus
Artigo em Inglês | IBECS | ID: ibc-131903


Objectives. The present study is to evaluate the expression level of enhancer of zeste homolog 2 (EZH2) and vascular endothelial growth factor (VEGF), and analyze their correlations with clinicopathological characteristics and survival in patients with clear cell renal cell carcinoma (CCRCC). The effect of EZH2 on apoptosis and cell proliferation in 786-O renal cancer cell line is investigated. Methods. The expression level of EZH2 and VEGF was detected in 185 primary CCRCC patients’ tissues using tissue microarray and immunohistochemistry. Small interfering RNA or enhanced green fluorescent protein transfection was employed to investigate the effect of EZH2 inhibition or overexpression on VEGF expression, apoptosis and cell proliferation in 786-O cells using flow cytometry, immunofluorescence microscopy, quantitative real-time reverse-transcription polymerase chain reaction and Western blot analysis. Results. High expression level of EZH2 and VEGF was observed in advanced CCRCC and correlated with the TNM stage (p = 0.013, p = 0.001) and distant metastasis (p = 0.011, p = 0.038), respectively. EZH2 was positively correlated with VEGF in CCRCC tissues (correlation coefficient = 0.850, p < 0.001). Kaplan–Meier survival analysis revealed that patients with positive EZH2 expression had a shorter overall survival time compared to patients with negative EZH2 expression (34.3 vs. 67.2, p < 0.001). In 786-O cells, EZH2 silencing inhibited VEGF expression and cell proliferation while increasing apoptosis (p < 0.001). EZH2 overexpression promoted VEGF expression and cell proliferation while inhibiting apoptosis (p < 0.001). Conclusions. EZH2 correlates positively with VEGF and associates with adverse clinicopathologic characteristics and shorter survival time in CCRCC patients. EZH2 accelerates antiapoptosis and cell cycle in 786-O cells (AU)

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Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Carcinoma de Células Renais/diagnóstico , Regulação Neoplásica da Expressão Gênica , Regulação Neoplásica da Expressão Gênica/imunologia , Receptor 3 de Fatores de Crescimento do Endotélio Vascular , MicroRNAs , Western Blotting/métodos , Western Blotting/tendências , Estimativa de Kaplan-Meier , Apoptose , Fator de Indução de Apoptose , Citometria de Fluxo/tendências