Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 26
Filtrar
1.
J Cardiol ; 76(2): 177-183, 2020 08.
Artigo em Inglês | MEDLINE | ID: mdl-32199753

RESUMO

BACKGROUND: Although recent attention to palliative care for patients with cardiovascular diseases has been increasing, there are no specific recommendations on detailed palliative care practices. We proceed on a discussion of the appropriateness and applicability of potential quality indicators for acute cardiovascular diseases according to our previous systematic review. METHODS: We created a multidisciplinary panel of 20 team members and 7 external validation clinicians composed of clinical cardiologists, a nutritionist, a physiotherapist, a clinical psychologist, a critical and emergent care specialist, a catheterization specialist, a primary care specialist, a palliative care specialist, and nurses. After crafting potential indicators, we performed a Delphi rating, ranging from "1 = minimum" to "9 = maximum". The criterion for the adoption of candidate indicators was set at a total mean score of seven or more. Finally, we subcategorized these indicators into several domains by using exploratory factor analysis. RESULTS: Sixteen of the panel members (80%) were men (age, 49.5 ± 13.7 years old). Among the initial 32 indicators, consensus was initially reached on total 23 indicators (71.8%), which were then summarized into 21 measures by selecting relatively feasible time variations. The major domains were "symptom palliation" and "supporting the decision-making process". Factor analysis could not find optimal model. Narratively-developed seven sub-categories included "presence of palliative care team", "patient-family relationship", "multidisciplinary team approach", "policy of approaching patients", "symptom screening and management", "presence of ethical review board", "collecting and providing information for decision-maker", and "determination of treatment strategy and the sharing of the care team's decision". CONCLUSION: In this study we developed 21 quality indicators, which were categorized into 2 major domains and 7 sub-categories. These indicators might be useful for many healthcare providers in the initiation and enhancement of palliative care practices for acute cardiovascular diseases in Japan.


Assuntos
Doenças Cardiovasculares/terapia , Cuidados Paliativos/normas , Indicadores de Qualidade em Assistência à Saúde , Adulto , Consenso , Técnica Delfos , Feminino , Humanos , Japão , Masculino , Pessoa de Meia-Idade
2.
Int J Qual Health Care ; 31(10): G139-G145, 2019 Dec 31.
Artigo em Inglês | MEDLINE | ID: mdl-31728518

RESUMO

PURPOSE: To examine the update status of clinical practice guidelines (CPGs) for 24 main diseases in Japan, and to clarify the quality of and issues pertaining to the most recent versions of CPGs for each disease. DATA SOURCES: CPGs were searched in two Japanese guideline databases. STUDY SELECTION: All relevant Japanese CPGs published between January 1999 and July 2016 were selected. DATA EXTRACTION: The developer and issue date were extracted for all target CPGs. The most recent CPGs were assessed using the Appraisal of Guidelines for Research and Evaluation-II (AGREE II) instrument. RESULTS OF DATA SYNTHESIS: Among 106 target CPGs, 24 most recent CPGs were subjected to assessment using the AGREE II instrument. CPGs for 11 diseases (46%) had a mean time interval for update of ≥5 years. Among the 24 CPGs subjected to AGREE II assessment, median domain scores were 74% for "Domain 1: Scope and Purpose," 43% for "Domain 2: Stakeholder Involvement," 46% for "Domain 3: Rigor of Development," 69% for "Domain 4: Clarity of Presentation," 24% for "Domain 5: Applicability" and 27% for "Domain 6: Editorial Independence." CONCLUSIONS: The systematic assessment of CPGs for 24 major diseases in Japan revealed a trend for a delay in timing of update for many CPGs. Moreover, the 24 most recent CPGs had low domain scores for domains 2, 3, 5 and 6. In the future, concrete measures will need to be considered in order to improve the quality of CPGs.


Assuntos
Medicina Baseada em Evidências , Guias como Assunto/normas , Humanos , Japão , Garantia da Qualidade dos Cuidados de Saúde/métodos
3.
J Phys Ther Sci ; 31(5): 429-434, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-31164780

RESUMO

[Purpose] To investigate how well rehabilitation is described in Japanese clinical practice guidelines of various diseases or disorders requiring rehabilitation. [Participants and Methods] Clinical practice guidelines were extracted from the MINDS database (Japan Council for Quality Health Care). Japanese clinical practice guidelines of specific diseases or disorders requiring rehabilitation were included. The exclusion criteria were clinical practice guidelines on the procedure, symptoms, and/or medical examination. To select the clinical practice guidelines of diseases or disorders requiring rehabilitation, eight participants evaluated the need for rehabilitation for the disease or disorder through the modified Delphi method. They graded the necessity of rehabilitation from 1 to 9 (1, completely disagree; 9, completely agree). The clinical practice guidelines that had grades 7 or higher as the median were included in the analyses. Systematic reviews were compiled as an indicator of the extent to which rehabilitation is described in clinical practice guidelines. [Results] Forty-four clinical practice guidelines were selected, and 26 (59.1%) included descriptions of rehabilitation. There were 443 existing systematic reviews related to rehabilitation for each disease or disorder enrolled in the present study and 67 (15.1%) systematic reviews quoted in those guidelines. [Conclusion] Rehabilitation was not well described in the clinical practice guidelines of the diseases or disorders that require rehabilitation.

4.
Microb Drug Resist ; 25(6): 915-924, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30897025

RESUMO

We investigated the prevalence and molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) among 356 residents of nine long-term care facilities (LTCFs) in Japan during 2015 and 2017. In total, 800 specimens were tested and 39 MRSA isolates were recovered from 31 (8.71%) residents. PCR-based open reading frame typing (POT) and pulsed-field gel electrophoresis typing were performed for the 39 MRSA isolates; five of them showing identical pulsotypes, and POT scores were excluded in further analysis. Staphylococcal cassette chromosome mec (SCCmec) typing, multilocus sequence typing, and toxin gene detection were performed for one representative MRSA isolate per resident. Among the 34 unrelated MRSA isolates, 15 (44.1%) and 19 (55.9%) were of SCCmec types II and IV, respectively, and belonged to seven sequence types (STs). Among the 15 SCCmec II isolates, 11 (73.3%), 3, and 1 belonged to ST764 (clonal complex [CC]5), ST5 (CC5), and ST630 (CC8), respectively. Among the 19 SCCmec IV isolates, 13 (68.4%), 3, 2, and 1 belonged to ST1 (CC1), ST474 (CC1), ST8 (CC8), and ST380 (CC8), respectively. Among the 14 CC5 lineage-SCCmec II isolates, one ST5 isolate and 7 of the 11 ST764 isolates (63.6%) carried seb gene, and 14 (87.5%) of 16 CC1 lineage-SCCmec IV isolates had sea gene (p < 0.05). The results indicate that the seb-positive SCCmec type II-ST764 clone has spread in Japanese LTCF environments. As LTCF residents have multiple comorbidities and increased susceptibility to infections, it is necessary to monitor MRSA colonization in LTCFs through periodic screening to prevent dissemination.


Assuntos
Antibacterianos/uso terapêutico , Staphylococcus aureus Resistente à Meticilina/isolamento & purificação , Meticilina/uso terapêutico , Infecções Estafilocócicas/tratamento farmacológico , Infecções Estafilocócicas/microbiologia , Idoso , Grupo com Ancestrais do Continente Asiático , Toxinas Bacterianas/genética , Cromossomos Bacterianos/genética , Infecção Hospitalar/tratamento farmacológico , Infecção Hospitalar/microbiologia , DNA Bacteriano/genética , Exotoxinas/genética , Genótipo , Humanos , Staphylococcus aureus Resistente à Meticilina/genética , Testes de Sensibilidade Microbiana/métodos , Tipagem de Sequências Multilocus/métodos , Fatores de Virulência/genética
5.
Int J Clin Oncol ; 24(2): 211-221, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30145745

RESUMO

BACKGROUND: To examine the effect of rehabilitation on postoperative pulmonary complication when it is conducted in combination of both before and after lung cancer surgery, as compared with either before or after surgery and no rehabilitation. METHODS: A retrospective cohort study was conducted to examine the effect of rehabilitation before and after lung cancer surgery on the causes of postoperative pneumonia. Data were collected from the diagnosis procedure combination (DPC) database. Patients admitted who received operative treatment for a new primary (ICD codes: C34) were selected. The inclusion criteria were patients who had pneumonectomy, malignant tumor surgery for the lung (thoracotomy), or thoracoscopic surgery (endoscopic; treatment code: K511-00, K513-00~03, and K514-00, 02). The exclusion criteria were patients who had a lung transplantation (treatment code: K514-03~06), suspected diagnosis, and a pneumonia within 3 months before being diagnosed as having lung cancer. Main outcome was onset of postoperative pneumonia. RESULTS: Among 76,739 lung cancer patients, 15,146 who underwent lung cancer surgery were included in the analysis. In the combination of pre- and postoperative group, as compared with the preoperative [odds ratio (OR), 95% confidence interval (CI) 2.8, 1.8-4.4], postoperative (1.9, 1.6-2.3), and no rehabilitation group (2.5, 2.1-2.8), the onset of pneumonia was less frequent. CONCLUSIONS: Combination of preoperative and postoperative rehabilitations significantly prevents postoperative pneumonia as compared with having preoperative, postoperative, or no rehabilitation.


Assuntos
Bases de Dados Factuais , Neoplasias Pulmonares/cirurgia , Pneumonectomia/efeitos adversos , Pneumonia/reabilitação , Complicações Pós-Operatórias/reabilitação , Toracotomia/efeitos adversos , Idoso , Feminino , Humanos , Japão , Neoplasias Pulmonares/diagnóstico , Masculino , Pneumonia/etiologia , Complicações Pós-Operatórias/etiologia , Período Pós-Operatório , Período Pré-Operatório , Prognóstico , Estudos Retrospectivos , Taxa de Sobrevida
6.
Phys Chem Chem Phys ; 20(20): 13974-13982, 2018 May 23.
Artigo em Inglês | MEDLINE | ID: mdl-29744493

RESUMO

Reactions of the free tantalum cation, Ta+, and tantalum cluster cations, Tan+ (n = 2-10), with ammonia are presented. The reaction of the monomer cation, Ta+, with two molecules of NH3 leads to the formation of TaN2H2+ along with release of two H2 molecules. The dehydrogenation occurs until the formal oxidation number of the tantalum atom reaches +5. On the other hand, all the tantalum cluster cations, Tan+, react with two molecules of NH3 and form TanN2+ with the release of three H2 molecules. Further exposure to ammonia showed that TanNmH+ and TanNm+ are produced through successive reactions; a pure nitride and three H2 molecules are formed for every other NH3 molecule. The nitridation occurred until the formal oxidation number of the tantalum atoms reaches +5 as in the case of TaN2H2+ in contrast to other group 5 elements, i.e., vanadium and niobium, which have been reported to produce nitrides with lower oxidation states. The present results on small gas-phase metal-nitride clusters show correlation with their bulk properties: tantalum is known to form bulk nitrides in the oxidation states of either +5 (Ta3N5) or +3 (TaN), whereas vanadium and niobium form nitrides in the oxidation state of +3 (VN and NbN). Along with DFT calculations, these findings reveal that nitridation is driven by the electron-donating ability of group 5 elements, i.e., electronegativity of the metal plays a key role in determining the composition of the metal nitrides.

7.
Microb Drug Resist ; 24(10): 1513-1520, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-29791251

RESUMO

We investigated the prevalence and characteristics of extended-spectrum ß-lactamase (ESBL)-producing Escherichia coli among 258 residents of long-term care facilities (LTCFs) in Japan. Out of 258 fecal samples collected from nine LTCFs between November 2015 and March 2017, we recovered 59 ESBL-producing E. coli isolates. All isolates carried blaCTX-M genes, mainly blaCTX-M-27 (42.4%), blaCTX-M-14 (23.7%), and blaCTX-M-15 (18.6%). The isolates showed 7 serotypes (STs), including ST131 (n = 49, 83.1%) and ST38 (n = 4, 6.8%), and 47 (79.7%) out of 49 isolates belonging to ST131 were identified as H30R. The 59 ESBL producers were divided into four groups, B2 (86.4%), D (8.5%), A (3.4%), and C (1.7%); 44 (74.6%) were epidemic clone B2-O25-ST131 H30R, of which 21, 11, and 6 harbored blaCTX-M-27, blaCTX-M-15, and blaCTX-M-14, respectively. Most plasmids were of IncF replicon types (n = 33), and 22 blaCTX-M-27-carrying plasmids showed multiple replicon types, including IncFII, FIA, and FIB. The ESBL producers were susceptible to imipenem, amikacin, and fosfomycin, but resistant to ceftazidime (49.2%), and ciprofloxacin (88.1%); in particular, the isolates harboring the blaCTX-M-15 gene showed significantly high resistance rate to ceftazidime (p < 0.01). Our findings indicate that a considerable proportion of the examined LTCF residents carried ESBL-producing E. coli isolates in feces and had high prevalence of epidemic clone B2-O25-ST131. Furthermore, continuous investigations would be very necessary to monitor actual carriage states of ESBL-producers among the LTCF residents from the viewpoint of both public health and healthcare viewpoints.


Assuntos
Antibacterianos/farmacologia , Infecções por Escherichia coli/epidemiologia , Proteínas de Escherichia coli/genética , Escherichia coli/isolamento & purificação , beta-Lactamases/genética , Idoso , Idoso de 80 Anos ou mais , Escherichia coli/enzimologia , Infecções por Escherichia coli/microbiologia , Fezes/microbiologia , Feminino , Humanos , Japão/epidemiologia , Assistência de Longa Duração , Masculino , Testes de Sensibilidade Microbiana , Pessoa de Meia-Idade , Plasmídeos , Prevalência , Resistência beta-Lactâmica
8.
Front Behav Neurosci ; 11: 173, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28979197

RESUMO

The parietal operculum (PO) often shows ipsilateral activation during tactile object perception in neuroimaging experiments. However, the relative contribution of the PO to tactile judgment remains unclear. Here, we examined the effect of transcranial direct current stimulation (tDCS) over bilateral PO to test the relative contributions of the ipsilateral PO to tactile object processing. Ten healthy adults participated in this study, which had a double-blind, sham-controlled, cross-over design. Participants discriminated grating orientation during three tDCS and sham conditions. In the dual-hemisphere tDCS conditions, anodal and cathodal electrodes were placed over the left and right PO. In the uni-hemisphere tDCS condition, anodal and cathodal electrodes were applied over the left PO and contralateral orbit, respectively. In the tDCS and sham conditions, we applied 2 mA for 15 min and for 15 s, respectively. Computational models of electric fields (EFs) during tDCS indicated that the strongest electric fields were located in regions in and around the PO. Compared with the sham condition, dual-hemisphere tDCS improved the discrimination threshold of the index finger contralateral to the anodal electrode. Importantly, dual-hemisphere tDCS with the anodal electrode over the left PO yielded a decreased threshold in the right finger compared with the uni-hemisphere tDCS condition. These results suggest that the ipsilateral PO inhibits tactile processing of grating orientation, indicating interhemispheric inhibition (IHI) of the PO.

9.
J Phys Ther Sci ; 29(2): 198-208, 2017 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-28265139

RESUMO

[Purpose] This study aimed to investigate Japanese physical therapists' attitudes of evidence-based practice and clinical practice guidelines. [Subjects and Methods] In 2014, a cross-sectional postal mail survey using a self-administered questionnaire was conducted. Of 2,982 physical therapists belonging to the Chiba Prefecture Physical Therapist Association, 1,000 were randomly selected. The questionnaire comprised 42 items pertaining to the attitudes of and behavior toward evidence-based practice and clinical practice guidelines. It was investigated to reveal the relationship between clinical practice guidelines/evidence-based practice and therapist characteristics. [Results] The response rate was 39.6%, and 384 questionnaires were available. The main results were as follows: 83.3% participants agreed to the importance of evidence-based practice, 77.1% agree to that evidence-based practice supports clinical decision of physical therapists, and about 11% agreed to have been educated about evidence-based practice. Then, 29.2% used, 54.9% agreed to the importance of, and 13.3% agreed to the utility of clinical practice guidelines. An important factor related mostly to a positive attitude, knowledge and behavior of evidence-based practice and clinical practice guidelines was participating in research activities. [Conclusion] Many of physical therapists do not use and understand the importance of clinical practice guidelines. Participating in research activities may partially contribute to improving these conditions.

10.
J Glob Antimicrob Resist ; 7: 19-23, 2016 12.
Artigo em Inglês | MEDLINE | ID: mdl-27973324

RESUMO

No reliable national antimicrobial consumption data have been available in Japan. The Japanese antimicrobial consumption surveillance (JACS) project started to collect data nationwide on antimicrobial consumption. This paper provides the first sales data from the JACS project on oral and parenteral antimicrobial consumption in Japan as well as the trends for the years from 2009 to 2013. The population-weighted total consumption was expressed as defined daily doses (DDDs) per 1000 inhabitants per day (DID). The value of DID increased from 14.7 in 2009 to 15.8 in 2013. Notably, oral antimicrobials accounted for 92.6% (mean of 2009, 2011 and 2013) of total consumption. Oral third-generation cephalosporins, macrolides and fluoroquinolones accounted for 77.1% (mean of 2009, 2011 and 2013) of oral consumption. Consumption of antimicrobials has increased during the years 2009 and 2013 regardless of the dosage form. This is the first report regarding the population-weighted consumption of oral and parenteral antimicrobials in Japan during the years 2009 and 2013. These results provide useful information for combating the menace of antimicrobial resistance in Japan.

11.
J Phys Ther Sci ; 28(4): 1307-11, 2016 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-27190473

RESUMO

[Purpose] The purpose of this study was to elucidate how well patients' perceptions related to the improvements in their hand function during hospitalization. [Subjects] Sixteen patients who were hospitalized after hand surgery. [Methods] Using the Japanese Society for Surgery of the Hand edition of the Quick-Disabilities of the Arm, Shoulder, and Hand questionnaire; tactile roughness discrimination acuity, motor imagery, motor function, sensory function, and pain of the upper limb were assessed at admission and discharge. Spearman's rank-order correlation coefficients were calculated using the differences in all assessment items at admission and discharge. A multiple regression analysis (stepwise method) was performed to investigate factors that correlated with improvements in Quick-Disabilities of the Arm, Shoulder, and Hand scores. [Results] The improvement of tactile roughness discrimination acuity was significantly associated with patient perception of improved hand function. [Conclusion] The results suggest that an improvement in tactile roughness discrimination acuity was most strongly correlated with patient perception of improved hand function.

12.
Front Neurosci ; 10: 128, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27064531

RESUMO

In healthy subjects, dual hemisphere transcranial direct current stimulation (tDCS) over the primary (S1) and secondary somatosensory cortices (S2) has been found to transiently enhance tactile performance. However, the effect of dual hemisphere tDCS on tactile performance in stroke patients with sensory deficits remains unknown. The purpose of this study was to investigate whether dual hemisphere tDCS over S1 and S2 could enhance tactile discrimination in stroke patients. We employed a double-blind, crossover, sham-controlled experimental design. Eight chronic stroke patients with sensory deficits participated in this study. We used a grating orientation task (GOT) to measure the tactile discriminative threshold of the affected and non-affected index fingers before, during, and 10 min after four tDCS conditions. For both the S1 and S2 conditions, we placed an anodal electrode over the lesioned hemisphere and a cathodal electrode over the opposite hemisphere. We applied tDCS at an intensity of 2 mA for 15 min in both S1 and S2 conditions. We included two sham conditions in which the positions of the electrodes and the current intensity were identical to that in the S1 and S2 conditions except that current was delivered for the initial 15 s only. We found that GOT thresholds for the affected index finger during and 10 min after the S1 and S2 conditions were significantly lower compared with each sham condition. GOT thresholds were not significantly different between the S1 and S2 conditions at any time point. We concluded that dual-hemisphere tDCS over S1 and S2 can transiently enhance tactile discriminative task performance in chronic stroke patients with sensory dysfunction.

13.
J Phys Ther Sci ; 27(9): 3003-5, 2015 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-26504345

RESUMO

[Purpose] The purpose of this study was to investigate the degree of collaboration between practitioners and researchers through research papers related to the implementation of electrical stimulation (ES) for stroke patients. [Methods] A systematic review of the literature was conducted to collect data from ES studies published before January 7, 2015. Five databases were searched for search terms related to stroke and ES. Inclusion criteria were original papers that reported on ES of the upper or lower limbs following stroke, after the exclusion of case reports, brain stimulation studies, and papers written in any languages other than English or Japanese. The outcome was the prevalence of research papers that included a practitioner as an author, that included a practitioner as an author or in the acknowledgements, and in which the practitioner was the first author. [Results] Based on the selection criteria, 165 papers were included in the final analysis. The prevalence of papers in which a practitioner was included as an author was 39%. The prevalence of papers in which a practitioner was included as an author or in the acknowledgements was 50%. A practitioner was the first author of 34% of the papers. [Conclusion] Collaboration on research papers related to ES for stroke patients is limited.

14.
Front Hum Neurosci ; 9: 671, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26733847

RESUMO

OBJECTIVE: We investigated the transient effect of short-duration paired-pulse electrical stimulation (ppES) on corticospinal excitability and the after-effect of long-duration ppES on excitability, short-latency afferent inhibition (SAI), and afferent facilitation (AF). METHODS: A total of 28 healthy subjects participated in two different experiments. In Experiment 1, motor-evoked potentials (MEPs) were measured in the abductor pollicis brevis (APB) and abductor digiti minimi (ADM) muscles before and immediately after short-duration ppES (5 s) at various inter-pulse intervals (2, 3, 4, 5, 6, 7, 10, 15, 20, and 30 ms). In Experiment 2, MEPs, SAI, and AF were measured before, immediately, and 20 and 40 min after long-duration ppES (20 min, inter-pulse interval of 5 and 15 ms) and peripheral electrical stimulation (20 min, 10 and 20 Hz). RESULTS: Short-duration ppES with inter-pulse intervals of 5 and 20 ms significantly increased MEP measured in APB but not in ADM. Long-duration ppES with an inter-pulse interval of 5 ms significantly decreased SAI but not MEPs in APB. In contrast, long-duration ppES did not affect ADM. CONCLUSION: The afferent inputs induced by ppES-5 ms were effective for transiently increasing MEP and sustaining SAI reduction.

15.
Clin Neurophysiol ; 125(8): 1669-74, 2014 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-24411524

RESUMO

OBJECTIVE: The aim of this study was to test the hypothesis that dual-hemisphere transcranial direct current stimulation (tDCS) over the primary somatosensory cortex (S1) could improve performance in a tactile spatial discriminative task, compared with uni-hemisphere or sham tDCS. METHODS: Nine healthy adults participated in this double-blind, sham-controlled, and cross-over design study. The performance in a grating orientation task (GOT) in the right index finger was evaluated before, during, immediately after and 30min after the dual-hemisphere, uni-hemisphere (1mA, 20min), or sham tDCS (1mA, 30s) over S1. In the dual-hemisphere and sham conditions, anodal tDCS was applied over the left S1, and cathodal tDCS was applied over the right S1. In the uni-hemisphere condition, anodal tDCS was applied over the left S1, and cathodal tDCS was applied over the contralateral supraorbital front. RESULTS: The percentage of correct responses on the GOT during dual-hemisphere tDCS was significantly higher than that in the uni-hemisphere or sham tDCS conditions when the grating width was set to 0.75mm (all p<0.05). CONCLUSIONS: Dual-hemisphere tDCS over S1 improved performance in a tactile spatial discrimination task in healthy volunteers. SIGNIFICANCE: Dual-hemisphere tDCS may be a useful strategy to improve sensory function in patients with sensory dysfunctions.


Assuntos
Córtex Somatossensorial/fisiologia , Processamento Espacial/fisiologia , Percepção do Tato/fisiologia , Tato/fisiologia , Estimulação Transcraniana por Corrente Contínua , Estimulação Magnética Transcraniana , Adulto , Análise de Variância , Atenção/fisiologia , Estudos Cross-Over , Método Duplo-Cego , Feminino , Lateralidade Funcional/fisiologia , Humanos , Masculino , Plasticidade Neuronal/fisiologia , Placebos , Valores de Referência , Inquéritos e Questionários , Adulto Jovem
16.
Gait Posture ; 37(3): 402-7, 2013 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-22963826

RESUMO

BACKGROUND: Trainings of the kneeling position, such as standing exercise on the knees and kneeling gait, have been anecdotally used in physical therapy to improve postural control of patients with various pathological conditions. However, clinical evidence is lacking and the movement characteristics of these kneeling trainings have not been well explored. The purpose of this study is to clarify the movement characteristics of the kneeling gait compared with the normal gait. METHODS: Twenty healthy volunteers (10 men and 10 women) aged 22-34 years were recruited. Participants were required to perform the kneeling gait and the normal gait at a self-selected comfortable speed on the treadmill. Surface electromyograms (EMG) and center of mass (COM) displacements were measured during each task. RESULTS: The EMGs of the gait-related proximal muscles during the kneeling gait were greater than during the normal gait, even at a comfortable speed. The COM displacement to the lateral direction was longer during the kneeling gait than it was during the normal gait. Furthermore, mechanical energy efficiency during the kneeling gait was less than that during the normal gait. CONCLUSION: The results suggest that the kneeling gait is an effective exercise to strengthen the gait-related proximal muscles. The increased muscle activities during the kneeling gait were probably due to the compensatory movements of the trunk and the pelvis.


Assuntos
Marcha/fisiologia , Músculo Esquelético/fisiologia , Equilíbrio Postural/fisiologia , Adulto , Fenômenos Biomecânicos , Eletromiografia , Técnicas de Exercício e de Movimento , Feminino , Humanos , Masculino , Movimento/fisiologia , Músculo Quadríceps/fisiologia , Reabilitação do Acidente Vascular Cerebral , Adulto Jovem
17.
Emerg Infect Dis ; 18(11): 1882-5, 2012 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-23092603

RESUMO

A population-based influenza surveillance study (using PCR virus subtyping) on Izu-Oshima Island, Japan, found that the cumulative incidence of influenza A(H1N1)pdm09 virus infections 2 seasons after the pandemic was highest for those 10-14 years of age (43.1%). No postpandemic A(H1N1)pdm09 case-patients had been infected with A(H1N1)pdm09 virus during the pandemic season.


Assuntos
Influenza Humana/epidemiologia , Orthomyxoviridae/genética , Pandemias , Adolescente , Criança , Pré-Escolar , Humanos , Incidência , Vírus da Influenza A Subtipo H1N1/genética , Influenza Humana/virologia , Ilhas , Japão/epidemiologia , Orthomyxoviridae/classificação , Vigilância da População , Estudos Retrospectivos , Estações do Ano , Adulto Jovem
18.
Antimicrob Agents Chemother ; 56(12): 6389-92, 2012 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-23006756

RESUMO

Five VanN-type vancomycin-resistant Enterococcus faecium strains were isolated from a sample of domestic chicken meat in Japan. All isolates showed low-level resistance to vancomycin (MIC, 12 mg/liter) and had the same pulsed-field gel electrophoresis profile. The vancomycin resistance was encoded on a large plasmid (160 kbp) and was expressed constitutively. The VanN-type resistance operon was identical to the first resistance operon to be reported, with the exception of a 1-bp deletion in vanT(N) and a 1-bp substitution in vanS(N).


Assuntos
Galinhas/fisiologia , Enterococcus faecium/efeitos dos fármacos , Carne/microbiologia , Resistência a Vancomicina/fisiologia , Animais , Primers do DNA , Bases de Dados Genéticas , Eletroforese em Gel de Campo Pulsado , Regulação Bacteriana da Expressão Gênica/genética , Japão , Testes de Sensibilidade Microbiana , Dados de Sequência Molecular , Tipagem de Sequências Multilocus , Óperon , Plasmídeos/genética , Vancomicina
19.
Phys Rev E Stat Nonlin Soft Matter Phys ; 80(1 Pt 2): 015304, 2009 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-19658762

RESUMO

We report a deformation phenomenon occurring at the interface between two immiscible liquids. The two liquids are in a cylindrical container and set into motion by a rotating lid positioned above the interface. The upper liquid is more viscous than the lower and the difference in densities between the liquids is fairly small. As the rotational speed of the lid (Omega) is increased in small increments, the center of the interface rises and the height increases. Depending on Omega , the topology of the interface changes drastically. The shape of the interface depends strongly on Omega and also the volume fraction of the liquids. Some dynamical behavior of the interface accompanies the changes in topology: interfacial waves, the generation of droplets, and interfacial instability.

20.
Antimicrob Agents Chemother ; 52(10): 3795-800, 2008 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-18694945

RESUMO

The mutation frequency for carbapenem resistance in Pseudomonas aeruginosa strains that were selected with carbapenems was enhanced in the presence of subinhibitory concentrations of fluoroquinolones. The mutants showed either a loss of OprD activity or increased mexAB-oprM expression. The highest mutant isolation frequency was obtained by selection with meropenem, while doripenem inhibited mutant growth.


Assuntos
Carbapenêmicos/farmacologia , Fluoroquinolonas/farmacologia , Mutação/efeitos dos fármacos , Pseudomonas aeruginosa/efeitos dos fármacos , Pseudomonas aeruginosa/genética , Tienamicinas/farmacologia , Resistência beta-Lactâmica/genética , Sequência de Bases , Primers do DNA/genética , DNA Bacteriano/genética , Doripenem , Genes Bacterianos/efeitos dos fármacos , Humanos , Técnicas In Vitro , Meropeném , Infecções por Pseudomonas/tratamento farmacológico , Infecções por Pseudomonas/microbiologia , Pseudomonas aeruginosa/isolamento & purificação
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...