Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 123
Filtrar
Mais filtros










Intervalo de ano de publicação
1.
J Biol Regul Homeost Agents ; 33(5 Suppl. 1): 7-11, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31630707

RESUMO

The purpose of this article is to review the main congenital anomalies of kidneys and urinary tract that can be diagnosed prenatally and postnatally by imaging technique. The incidence of congenital anomalies of the kidney and urinary tract during the past decade has been estimated to be 0.4 to 4.0 cases per 1000 births. Congenital kidney disease can evolve in chronic disease in childhood and in adulthood. A diagnostic imaging of the various congenital renal and urological conditions allows pediatricians to make a correct diagnosis and treatment. Because of the concerns about long-term effects of ionizing radiation, the most commonly and first used imaging modality for evaluation of the urinary system is ultrasound.


Assuntos
Nefropatias/congênito , Nefropatias/diagnóstico por imagem , Rim/patologia , Sistema Urinário/patologia , Humanos , Recém-Nascido , Rim/diagnóstico por imagem , Pediatria , Sistema Urinário/diagnóstico por imagem
2.
J Biol Regul Homeost Agents ; 33(5 Suppl. 1): 45-51, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31630713

RESUMO

Nocturnal enuresis (NE) was defined by the World Health Organization (ICD-10) and the American Psychiatric Association (DSM-5) as bed-wetting in children aged >5 years. In cases of mental retardation, the developmental age may be equivalent to 5 years. In this review, we focus on the current knowledge about the etiology of enuresis and the most recent therapeutical options. Both non-pharmacological and pharmacological therapies are included, although the relative effectiveness of each remains uncertain. To date, motivational, alarm and drug therapies are the mainstay of treatment. Alarm therapy remains the first-line treatment modality for NE, while desmopressin is the most commonly used medical treatment.


Assuntos
Desamino Arginina Vasopressina/uso terapêutico , Enurese Noturna/terapia , Criança , Pré-Escolar , Humanos
3.
J Biol Regul Homeost Agents ; 33(5 Suppl. 1): 65-67, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31630716

RESUMO

The use of the dilated ureter for bladder augmentation is universally accepted for its lower rate of complications compared to the use of gastrointestinal segments. We report the case of a 16 yearold boy affected by Goldenhar syndrome who presented with neurogenic bladder with small-capacity, 5° grade vescico-ureteral reflux (VUR) with megaureter and bilateral hydronephrosis. Bladder augmentation using the distal dilated ureter, transuretero-ureterostomy left to right and Mitrofanoff's appendicovescicostomy were performed. Six months after surgery voiding cystourethrogram (VCUG) revealed a compliant bladder with a functional capacity of 400 ml. Ureterocystoplasty is a safe and effective method of augmenting small capacity urinary bladder. We suggest using the ureter, when available, instead of using gastrointestinal segments.


Assuntos
Síndrome de Goldenhar/cirurgia , Bexiga Urinaria Neurogênica/cirurgia , Procedimentos Cirúrgicos Urológicos , Adolescente , Humanos , Masculino , Ureter/cirurgia
4.
J Biol Regul Homeost Agents ; 33(5 Suppl. 1): 79-85, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31630719

RESUMO

Obesity in children has been recognized as a major underlying factor of the pathogenesis of several diseases and a reduced life expectancy. This study aims to verify if clinical parameters, such as waist circumference and/or body mass index and biohumoral and inflammatory parameters can help predict cardiac structural and functional alterations, through an echocardiogram test in obese children and adolescents. Children were prospectively enrolled at the AUOC outpatients' department of Emergency Paediatrics, University Hospital, Messina, from June to December 2017. Clinical, metabolic parameters and an inflammation marker (HMGB1) were evaluated and a transthoracic echocardiogram was carried out. Twenty-two obese subjects were prospectively enrolled.HMGB1 values were 12.6 ± 2ng/ml, significantly higher compared to a previously studied healthy control group. A significant positive correlation was found both between total cholesterol levels and HMGB1 values (r=0.846, p=0.000) and between LDL cholesterol and HMBG1 values (r=0.663, p=0.001). No correlation was found between clinical, biohumoral and echocardiograph parameters. In obese children cardiac parameters obtained from echocardiogram tests may be in the normal range. However, other parameters may be altered in the early phase, showing that infantile obesity can compromise myocardial functions, even in the absence of comorbidities. Furthermore, the evaluation of concentrations of HMBG1 could explain how an initial inflammation can trigger the condition of meta-inflammation.


Assuntos
Cardiopatias/complicações , Obesidade Pediátrica/complicações , Adolescente , Índice de Massa Corporal , Criança , LDL-Colesterol/sangue , Proteína HMGB1/sangue , Humanos , Dados Preliminares , Estudos Prospectivos , Circunferência da Cintura
5.
J Biol Regul Homeost Agents ; 33(5 Suppl. 1): 91-94, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31630721

RESUMO

The natural history of children with end stage renal disease is dialysis until a transplant can be done. There are two types of dialysis: hemodialysis and peritoneal dialysis (1). Peritoneal dialysis is preferred in young children because getting the vascular access for hemodialysis is challenging (2). Catheters should be surgically placed in a paramedian or lateral abdominal region with an extremity located in Douglas' pouch.


Assuntos
Falência Renal Crônica/terapia , Ozônio/uso terapêutico , Diálise Peritoneal , Criança , Humanos
6.
J Biol Regul Homeost Agents ; 33(5 Suppl. 1): 95-103, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31630722

RESUMO

Despite laparoscopy in children is considered safe and is routinely used for several procedures, even in neonates and in pediatric oncology, its role in the treatment of pediatric renal tumors is still controversial. This study analyzes the results of laparoscopic nephrectomy for Wilms Tumor (WT) in pediatric age compared with open nephrectomy after 10 years of experience in a single centre. From 1993 in our center of reference for pediatric oncology, 30 patients with WT have been treated. We performed 21 open nephrectomy and in the last 10 years 9 laparoscopic nephrectomy. In all patients treated laparoscopically, the same technique made by the same equip was used. Compared with patients treated by open surgery, we did not find a significant difference in terms of outcome and survival. In the open surgery group, two patients had lung relapse while in the other group there was one local relapse. These three children obtained and maintained a second complete remission with chemotherapy. Open surgery complications were a tumor rupture in two cases, and an episode of pancreatitis 10 days after surgery. In the laparoscopic group, there were two conversions to open surgery not considered as complications but a surgical choice for cystic areas present in the tumor. As far as complications and oncologic outcomes are concerned, both techniques showed similar results. In experienced hands, laparoscopy proves to be an attractive alternative to open surgery for pediatric renal tumors.


Assuntos
Neoplasias Renais/cirurgia , Laparoscopia , Nefrectomia , Tumor de Wilms/cirurgia , Criança , Humanos , Recidiva Local de Neoplasia , Resultado do Tratamento
7.
J Biol Regul Homeost Agents ; 33(5 Suppl. 1): 105-110, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31630723

RESUMO

Pelviureteric junction obstruction (PUJO) due to intrinsic or extrinsic causes is a common problem in childhood. Extrinsic compression by a lower pole-crossing blood vessel can present symptomatically in older children. In these cases, laparoscopies Vascular Hitch can represent a valid alternative to pyeloplasty dismembered. We analyzed the data of 4 children affected by extrinsic PUJO treated at our institution with the laparoscopic Vascular Hitch procedure modified by Chapman. Surgical indications included presence of clinical symptoms, worsening of intermittent hydronephrosis, signs of obstruction on the MAG-3 scan, clear or suspected images of polar crossing vessels on CT scan or Uro-MRI. All procedures were completed laparoscopically. No complications occurred. Mean follow-up was 13 months with resolution of symptoms and PUJ obstruction and significant improvement of hydronephrosis in all cases. When blood vessels crossing lower pole represent the pure mechanical cause of UPJ obstruction the laparoscopic Vascular Hitch procedure represents an excellent alternative to dismembered pyeloplasty. It is less technically demanding then pyeloplasty and is associated with a lower complication rate. The main challenge is to intraoperatively ascertain the absence of associated intrinsic stenosis.


Assuntos
Hidronefrose/congênito , Laparoscopia , Rim Displásico Multicístico/cirurgia , Obstrução Ureteral/cirurgia , Procedimentos Cirúrgicos Urológicos , Idoso , Criança , Humanos , Hidronefrose/cirurgia , Pelve Renal
8.
Int J Obes (Lond) ; 41(3): 427-433, 2017 03.
Artigo em Inglês | MEDLINE | ID: mdl-28017964

RESUMO

BACKGROUND/OBJECTIVES: This trial evaluated the safety and effectiveness of the Orbera Intragastric Balloon as an adjunct to lifestyle intervention. SUBJECTS/METHODS: In this multicenter, randomized, open-label clinical trial, 255 adults with a body mass index of 30-40 kg m-2 were treated and outcomes were assessed up to 12 months. Participants were randomized to endoscopic placement of an intragastric balloon plus lifestyle or lifestyle intervention alone. Balloons were removed at 6 months and lifestyle intervention continued for both groups through 12 months. At 9 months, coprimary end points were two measures of weight loss. RESULTS: At 6 months, weight loss was -3.3% of total body weight (-3.2 kg) in the lifestyle arm vs -10.2% (-9.9 kg) in the balloon plus lifestyle arm (P<0.001); at 9 months (3 months postballoon removal), weight loss was -3.4% (-3.2 kg) vs -9.1% (-8.8 kg, P⩽0.001); and at 12 months, -3.1% (-2.9 kg) vs -7.6% (-7.4 kg, P⩽0.001). For the primary end points, at 9 months, mean percent loss of weight in excess of ideal body weight (s.d.) at 9 months was 26.5% (20.7) (P=0.32) and 9.7% (15.1) in the balloon and control groups, respectively. Also, 45.6% (36.7, 54.8) of the subjects randomized to the balloon achieved at least 15% loss of weight in excess of ideal body weight greater than the control group (P<0.001). The majority of balloon subjects experienced adverse events; 86.9% nausea, 75.6% vomiting, 57.5% abdominal pain and 18.8% had their device removed before 6 months because of an adverse event or subject request. Five subjects (3.1%) in the balloon group had a gastric abnormality at the time of device removal, and no ulcers were found. CONCLUSIONS AND RELEVANCE: Intragastric balloon achieved greater short-term weight loss at 3 and 6 months postballoon removal than lifestyle intervention alone. Adverse gastrointestinal events were common.


Assuntos
Balão Gástrico , Gastroscopia , Obesidade Mórbida/prevenção & controle , Obesidade Mórbida/terapia , Comportamento de Redução do Risco , Dor Abdominal , Adulto , Índice de Massa Corporal , Remoção de Dispositivo , Método Duplo-Cego , Feminino , Seguimentos , Balão Gástrico/efeitos adversos , Gastroscopia/efeitos adversos , Gastroscopia/métodos , Humanos , Masculino , Náusea , Obesidade Mórbida/epidemiologia , Complicações Pós-Operatórias , Estudos Prospectivos , Fatores de Tempo , Resultado do Tratamento , Estados Unidos/epidemiologia , Vômito , Perda de Peso
10.
Vet J ; 207: 85-91, 2016 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-26639824

RESUMO

This study aimed to investigate potential new target(s)/mechanism(s) for the palmitoylethanolamide (PEA) analogue, adelmidrol, and its role in an in vitro model of contact allergic dermatitis. Freshly isolated canine keratinocytes, human keratinocyte (HaCaT) cells and human embryonic kidney (HEK)-293 cells, wild-type or transfected with cDNA encoding for N-acylethanolamine-hydrolysing acid amidase (NAAA), were treated with adelmidrol or azelaic acid, and the concentrations of endocannabinoids (anandamide and 2-arachidonoylglycerol) and related mediators (PEA and oleoylethanolamide) were measured. The mRNA expression of PEA catabolic enzymes (NAAA and fatty acid amide hydrolase, FAAH), and biosynthetic enzymes (N-acyl phosphatidylethanolamine-specific phospholipase D, NAPE-PLD) and glycerophosphodiester phosphodiesterase 1, was also measured. Brain or HEK-293 cell membrane fractions were used to assess the ability of adelmidrol to inhibit FAAH and NAAA activity, respectively. HaCaT cells were stimulated with polyinosinic-polycytidylic acid and the release of the pro-inflammatory chemokine, monocyte chemotactic protein-2 (MCP-2), was measured in the presence of adelmidrol. Adelmidrol increased PEA concentrations in canine keratinocytes and in the other cellular systems studied. It did not inhibit the activity of PEA catabolic enzymes, although it reduced their mRNA expression in some cell types. Adelmidrol modulated the expression of PEA biosynthetic enzyme, NAPE-PLD, in HaCaT cells, and inhibited the release of the pro-inflammatory chemokine MCP-2 from stimulated HaCaT cells. This study demonstrates for the first time an 'entourage effect' of adelmidrol on PEA concentrations in keratinocytes and suggests that this effect might mediate, at least in part, the anti-inflammatory effects of this compound in veterinary practice.


Assuntos
Anti-Inflamatórios não Esteroides/farmacologia , Dermatite Alérgica de Contato/veterinária , Ácidos Dicarboxílicos/farmacologia , Etanolaminas/metabolismo , Queratinócitos/efeitos dos fármacos , Ácidos Palmíticos/metabolismo , Ácidos Palmíticos/farmacologia , Amidoidrolases/metabolismo , Animais , Membrana Celular/enzimologia , Sobrevivência Celular/efeitos dos fármacos , Quimiocina CCL8/metabolismo , Dermatite Alérgica de Contato/tratamento farmacológico , Dermatite Alérgica de Contato/metabolismo , Cães , Regulação para Baixo , Endocanabinoides/metabolismo , Células HEK293 , Humanos , Inflamação/metabolismo , Queratinócitos/metabolismo , RNA Mensageiro/metabolismo
11.
G Ital Dermatol Venereol ; 150(3): 309-16, 2015 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-25236315

RESUMO

AIM: The aims of this study were to describe the quality of life (QoL) in patients suffering of scalp psoriasis and to assess the impact of the socio-demographic and clinical features of this condition on patients' health-related QoL, using general and specific QoL scales. METHODS: This research is a cross-sectional study. The study involved 55 patients attending their first examination at the Dermatology Clinic of Padua University over the course of one year (April 2010-March 2011). The outcome was quality of life analyzed by means Scalpdex and SF-36 questionnaire. RESULTS: The sample's mean Scalpdex score was 43.60±17.52, while the mean SF-36 score was 68.28±20.32. The SF-36 identified statistically significant differences between the psoriasis patients and the Italian general population in two domains, i.e. general health (P=0.0075) and emotional role (P=0.0048). The severity of patients' scalp lesions emerged as a factor associated with a reduced QoL in these patients, irrespective of the severity of their disease as a whole. Sex, age, schooling and other socio-demographic factors also characterized patients' perceived QoL. CONCLUSION: Patients with scalp psoriasis suffered from a lower QoL relating to the highly visible site of their psoriatic lesions. Specific supportive measures should be dedicated to these patients by health care workers.


Assuntos
Avaliação do Impacto na Saúde , Psoríase/psicologia , Qualidade de Vida , Dermatoses do Couro Cabeludo/psicologia , Adulto , Artrite Psoriásica/epidemiologia , Imagem Corporal , Comorbidade , Estudos Transversais , Escolaridade , Emoções , Emprego , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Obesidade/epidemiologia , Índice de Gravidade de Doença , Fumar/epidemiologia , Percepção Social , Fatores Socioeconômicos , Inquéritos e Questionários
12.
Ann Ig ; 26(5): 409-17, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25405371

RESUMO

BACKGROUND: The elderly are involved in an ever-increasing proportion of Emergency Department (ED) visits, consuming a large share of the available resources. The aim of this study was to assess elderly individuals' demand for ED hospital care, in terms of the management process and outcomes by level of urgency at triage. METHODS: The design was a retrospective cohort study. Details on ED attendance were drawn from the 2010 dataset of the Local Health Agency n°18 (n=18,648) in the Veneto Region, North-East Italy and the participants were resident seniors seen at the ED aged 65 or more. RESULTS: At triage on arrival, their priority was most often (in 38.63% of cases) considered non-urgent (white triage tag - Wt). In the majority of these cases, the elderly patients were self-referred, although about 1 in 5 of them had been referred by their General Practitioners. The consumption of resources for specialist visit and routine X-rays is higher for non-urgent patients. Injuries, requests for specialist examinations and musculoskeletal disorders account for a large proportion of the reasons why elderly people classified as Wt at triage had gone to the ED. CONCLUSIONS: Our findings show that older patients have high rates of non-urgent ED attendance, especially for minor traumatic events or requests to see a specialist. This picture emphasizes the need to develop new organizational models for delivering care to meet the most common health care needs of this special frail population.


Assuntos
Serviço Hospitalar de Emergência/estatística & dados numéricos , Índice de Gravidade de Doença , Triagem/estatística & dados numéricos , Idoso , Idoso de 80 Anos ou mais , Estudos de Coortes , Assistência à Saúde/organização & administração , Feminino , Idoso Fragilizado , Necessidades e Demandas de Serviços de Saúde , Humanos , Itália , Masculino , Modelos Organizacionais , Encaminhamento e Consulta/estatística & dados numéricos , Estudos Retrospectivos
13.
Diabetes Obes Metab ; 16(10): 1009-15, 2014 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-24824326

RESUMO

AIMS: The 5-year, open-label, prospective, observational helping evaluate reduction in obesity (HERO) study (N = 1106) examines efficacy and safety of the LAP-BAND AP(®) laparoscopic adjustable gastric band (LAGB) in obese patients. This interim analysis assessed the control of type 2 diabetes (T2D), 1 year after the implantation of the LAGB. METHODS: Baseline T2D was defined by chart review or use of antidiabetic medications or haemoglobin A1c (HbA1c) ≥ 7.0%. Control of T2D at 1 year was defined as A1c <7.0% (with or without antidiabetic medications). RESULTS: After 1 year, 187 of 273 patients with T2D at baseline had adequate data available to assess T2D status, of which 135 patients (72.2%) achieved target control of T2D compared with 42.8% control rate at baseline. Independent predictors of achieving target control at 1 year included the following: (i) shorter diabetes duration odds ratio (OR) 0.914 [95% confidence interval (CI), 0.839, 0.995, p = 0.038], (ii) not using insulin therapy OR 0.16 (95% CI, 0.06, 0.47, p < 0.001) and (iii) greater mean % weight loss OR 1.176 (95% CI, 1.093, 1.266, p < 0.001). Patients using insulin at baseline were 84% less likely to achieve control of T2D after 1 year; each additional year of diabetes at baseline reduced the likelihood of good control by 9%; and each 1% of weight loss increases the likelihood of good control by 18%. Rates of device-related adverse events and reoperations were low and were not significantly different between patients with and without baseline T2D at 1 year. CONCLUSIONS: Greater % weight loss, not using insulin therapy, and shorter disease duration predicted increased likelihood of target control of T2D, 1 year after implantation of the LAGB.


Assuntos
Diabetes Mellitus Tipo 2/prevenção & controle , Gastroplastia , Hemoglobina A Glicada/metabolismo , Laparoscopia , Obesidade Mórbida/cirurgia , Perda de Peso , Adulto , Diabetes Mellitus Tipo 2/epidemiologia , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Obesidade Mórbida/complicações , Obesidade Mórbida/epidemiologia , Estudos Prospectivos , Indução de Remissão , Fatores de Tempo , Resultado do Tratamento , Estados Unidos/epidemiologia
14.
Curr Med Chem ; 19(9): 1295-9, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22304707

RESUMO

Multiple sclerosis (MS) has been considered for a long time a typical inflammatory demyelinating disease of the central nervous system due to autoimmunity targeting oligodendrocytes with sparing of axons until advanced stages of the disease. For this reason, most of the earliest experimental studies focused on the role of cytokines and chemokines at the site of oligodendrocytes loss and on the importance in MS pathogenesis of classical inflammatory mechanisms. As a result, several attempts to treat MS through reduction of the local inflammatory milieau have been performed, leading to the current "immunomodulatory" treatment of the disease. However, more recently the importance of axonal loss and neurodegeneration even in the earliest stages of MS has been also recognized, and additional or concomitant players have been therefore searched. Evidence is now increasing that excessive glutamate is released at the site of demyelination and axonal degeneration in MS plaques, and the most probable candidates for this cellular release are infiltrating leukocytes and activated microglia. These observations are no longer simply preclinical results obtained in the MS animal model, i.e. experimental allergic encephalomyelitis, but have already been partially confirmed by post-mortem studies and in vivo analysis in MS patients, thus raising the possibility that modulation of glutamate release and transport as well as receptors blockade might be relevant targets for the development of future therapeutic interventions.


Assuntos
Sistema Nervoso Central/metabolismo , Sistema Nervoso Central/patologia , Ácido Glutâmico/metabolismo , Esclerose Múltipla/metabolismo , Esclerose Múltipla/patologia , Animais , Sistema Nervoso Central/imunologia , Doenças Desmielinizantes/imunologia , Doenças Desmielinizantes/metabolismo , Doenças Desmielinizantes/patologia , Ácido Glutâmico/imunologia , Humanos , Esclerose Múltipla/imunologia , Estresse Oxidativo
15.
Epidemiol Prev ; 35(5-6 Suppl 4): 189-91, 2011.
Artigo em Italiano | MEDLINE | ID: mdl-22166301

RESUMO

Cancer incidence is an outcome of interest in studies assessing the health impact of polluted sites, for which an example is represented by SENTIERI Project. Incidence data are characterized by better diagnostic quality and are not influenced by survival factors, furthermore they allow the investigation of high-survival neoplasms (i.e. childhood cancer) and rare malignancies. Furthermore, the study of incidence is more informative than mortality for non-lethal tumours, therefore it represents an advancement in respect to the study of mortality completed in SENTIERI Project. In the last decade in Italy some environmental epidemiology studies used cancer register data, for example the Biancavilla (Sicily) investigation on fluoro-edenite related mesothelioma and the study in an area of Naples Province where hazardous waste was extensively dumped. In this frame, ISS planned some collaborative studies with Siracusa, Mantua and Ferrara cancer Registries, where three major polluted sites are located. Following these pilot studies an ISS-AIRTUM (Italian Association of Cancer Registries) collaborative study has been planned. For a description of SENTIERI, refer to the 2010 supplement of Epidemiology & Prevention, devoted to the Project.


Assuntos
Saúde Ambiental/métodos , Poluição Ambiental/efeitos adversos , Resíduos Perigosos/efeitos adversos , Resíduos Industriais/efeitos adversos , Neoplasias/epidemiologia , Vigilância da População/métodos , Sistema de Registros , Exposição Ambiental , Poluição Ambiental/estatística & dados numéricos , Substâncias Perigosas/efeitos adversos , Resíduos Perigosos/estatística & dados numéricos , Humanos , Incidência , Resíduos Industriais/estatística & dados numéricos , Itália/epidemiologia , Estudos Multicêntricos como Assunto
16.
Epidemiol Prev ; 35(5-6 Suppl 4): 192-8, 2011.
Artigo em Italiano | MEDLINE | ID: mdl-22166302

RESUMO

The collaborative study between Istituto superiore di sanità and Associazione italiana registri tumori (ISS-AIRTUM) aims at investigating cancer incidence in polluted sites for adults and for children (0-14 years) and adolescents (15-19 years) to comment the study results in the light of a set of a priori hypotheses. On the whole, 141 out of 298 municipalities included in SENTIERI Project are served by a Cancer Register participating to the AIRTUM network. For a description of SENTIERI, refer to the 2010 Supplement of Epidemiology & Prevention devoted to SENTIERI Project. The time window of the study is the period 1996-2005. The number of expected cases in each polluted site will be estimated by applying incidence rates of the national pool of cancer registries and of the pool of the geographic macroarea in which each site is located: Northern, Central, Southern Italy and Islands. Cancer incidence in children and adolescents is one of the main priorities of international public health institutions, because of the need to protect childhood health from involuntary exposure to environmental risk factors. Standardized incidence ratios (SIRs) will be computed using expected figures derived from the national pool of cancer registries.


Assuntos
Academias e Institutos , Comportamento Cooperativo , Poluição Ambiental/efeitos adversos , Resíduos Perigosos/efeitos adversos , Neoplasias/epidemiologia , Vigilância da População/métodos , Sistema de Registros , Adolescente , Adulto , Idade de Início , Criança , Pré-Escolar , Exposição Ambiental , Poluição Ambiental/estatística & dados numéricos , Feminino , Substâncias Perigosas/efeitos adversos , Resíduos Perigosos/estatística & dados numéricos , Humanos , Incidência , Lactente , Recém-Nascido , Itália/epidemiologia , Masculino , Saúde da População Urbana , Adulto Jovem
17.
Braz. j. microbiol ; 41(3): 581-587, Oct. 2010. ilus, tab
Artigo em Inglês | LILACS | ID: lil-549398

RESUMO

Antibacterial activity of organic and aqueous extracts of Acacia aroma was evaluated against methicillin-resistant Staphylococcus aureus (MRSA), methicillin sensitive Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus epidermidis. Inhibition of bacterial growth was determined using agar diffusion and bioautographic methods. Among all assayed organic extracts only ethanolic and ethyl acetate extracts presented highest activities against all tested Staphylococcus strains with minimal inhibitory concentration (MIC) values ranging from 2.5 to 10 mg/ml and from 2.5 to 5 mg/ml respectively. The aqueous extracts show little antibacterial activity against Staphylococcus strains. The bioautography assay demonstrated well-defined growth inhibition zones against S. aureus in correspondence with flavonoids and saponins. A. aroma would be an interesting topic for further study and possibly for an alternative treatment for skin infections.


Assuntos
Humanos , Antibacterianos , Acacia/crescimento & desenvolvimento , Estruturas Vegetais/crescimento & desenvolvimento , Extratos Vegetais/análise , Resistência a Meticilina , Staphylococcus epidermidis/isolamento & purificação , Crescimento Bacteriano , Métodos , Técnicas
18.
Eur J Clin Nutr ; 64(8): 894-8, 2010 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-20502467

RESUMO

BACKGROUND/OBJECTIVES: Disease-related malnutrition is a common comorbidity at hospital admission. The purpose of the present report was to describe the data on nutritional care routines collected during the Project: Iatrogenic MAlnutrition in Italy (PIMAI) study, as these may be helpful to avoid iatrogenic malnutrition and improve nutritional policies. SUBJECTS/METHODS: Standards of nutritional care were assessed on the basis of (1) adherence to study protocol (completeness of data collected); (2) attitude in assessing the nutritional status; (3) prescription of nutritional therapy (within 3 days) at least in patients presenting with overt malnutrition (body mass index (BMI) <18.5 kg/m(2) or significant weight loss (>or=10% in 3 months and/or >or=5% in the last month)), regardless of its adequacy, and adherence to current guidelines and (4) attitude in monitoring nutritional status during the stay (number of weight measurements performed compared with those expected). RESULTS: In total, 1583 subjects were assessed. A minimum data set for performing the Nutritional Risk Screening 2002 tool was available in 1284 patients (81.1%), but nutritional screening was possible in every patient by alternative analytical criteria related to food intake, anthropometry and biochemistry. However, several missing values were recorded, particularly in biochemical parameters due to lack of prescription by admission wards. According to ward practices, only 38.2% of the patients had the BMI calculated. A nutritional support was prescribed only to 26/191 patients (13.6%) presenting with overt malnutrition. Finally, we recorded that only 21.6% of the patients (207/960 were randomly selected) had their weight monitored on a scheduled basis. This reality was worse in surgical rather than medical departments (17 vs 26%; P<0.001). CONCLUSION: Present results confirm that in Italy, nutritional care routines are still poor and need improvements.


Assuntos
Assistência à Saúde/normas , Hospitalização , Desnutrição/terapia , Avaliação Nutricional , Ciências da Nutrição , Apoio Nutricional/estatística & dados numéricos , Antropometria , Atitude do Pessoal de Saúde , Biomarcadores/análise , Índice de Massa Corporal , Competência Clínica , Comorbidade , Ingestão de Energia , Guias como Assunto , Humanos , Itália/epidemiologia , Desnutrição/diagnóstico , Desnutrição/epidemiologia , Inquéritos Nutricionais , Medição de Risco , Perda de Peso
19.
Curr Pharm Des ; 16(7): 840-6, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-20388095

RESUMO

Lipid peroxidation has supposed as the major biochemical alteration underling oxidant-induced cell injury in stress including numerous diseases. One of the natural molecules know to prevent or retard oxidation is alpha-lipoic acid (LA) and, therefore, the lipoic acid/dihydrolipoic acid (LA/DHLA) redox couple has received considerable attention. Recent studies have highlighted the potential of free LA and DHLA as powerful metabolic antioxidants that are able to scavenge the reactive oxygen species, to recycle other antioxidants. Our aim was to investigate the beneficial effects of LA in the treatment of Italian pre-obese and obese subjects. We screened 1612 subjects for enrollment; of these, 1127 subjects (445 men and 682 women, 18-60 age) met enrolment criteria and were enrolled in the study. According to body mass index (BMI) the 53% was obese and the 43% was pre-obese. The subjects were treated for 4 month with 800 mg/day of LA. In pre-obese subject significant reduction (p<0.001) of weight (8%, both gender), BMI (2 points), blood pressure, and abdominal circumference (female 6 cm, male 7 cm) were observed. In obese subjects significant reductions (p<0.001) of weight (9%, both gender), BMI (female 3 point, male 4 point), blood pressure and abdominal circumference (female 9 cm, male 11 cm) were observed. Our study indicated that LA is an ideal antioxidant candidate for the therapy of obesity related diseases. Further clinical studies should be considered to highlight the role and efficacy of LA treatment.


Assuntos
Antioxidantes/administração & dosagem , Obesidade/tratamento farmacológico , Ácido Tióctico/administração & dosagem , Adolescente , Adulto , Pressão Sanguínea/efeitos dos fármacos , Índice de Massa Corporal , Peso Corporal/efeitos dos fármacos , Suplementos Nutricionais , Feminino , Humanos , Peroxidação de Lipídeos/efeitos dos fármacos , Masculino , Pessoa de Meia-Idade , Oxirredução , Espécies Reativas de Oxigênio/metabolismo , Ácido Tióctico/análogos & derivados , Adulto Jovem
20.
J Neuroimmunol ; 220(1-2): 104-7, 2010 Mar 30.
Artigo em Inglês | MEDLINE | ID: mdl-20149932

RESUMO

OBJECTIVE AND SUBJECTS: To examine in vivo levels of BAFF (B-cell activating factor of the tumor necrosis factor family) and APRIL (a proliferation-inducing ligand) in both the cerebrospinal fluid (CSF) and serum of 30 naïve MS patients and 79 subjects affected by acute or chronic inflammatory or non-inflammatory neurological diseases. DESIGN: Case-control study. RESULTS: No difference among groups was evidenced in serum BAFF or APRIL levels. By contrast, CSF levels of BAFF in MS (mean 144.3 pg/ml+/-141.2), although not significantly different from those observed in NIND (164.2 pg/ml+/-92.0), acute peripheral OIND (243.1 pg/ml+/-139.0) or chronic OIND (240.2 pg/ml+/-122.5), were significantly higher in acute central OIND patients (1274.0 pg/ml+/-803.8; p<0.001 vs. all groups). Similarly, CSF APRIL levels in MS (1541.0 pg/ml+/-1071.0), NIND (2629.0 pg/ml+/-1669.0), acute peripheral OIND (2834.0 pg/ml+/-1118.) or chronic OIND (2764.0 pg/ml+/-659.7) were not significantly different, while they were significantly higher in acute central OIND (6218.0 pg/ml+/-3790.0; p<0.001 vs. MS and NIND; and p<0.05 vs. acute peripheral OIND). CONCLUSIONS: Our results strongly suggest that further investigation is warranted to elucidate the role of BAFF and APRIL in MS and that serum levels of BAFF and APRIL do not reflect CSF levels.


Assuntos
Fator Ativador de Células B/líquido cefalorraquidiano , Sistema Nervoso Central/imunologia , Sistema Nervoso Central/metabolismo , Esclerose Múltipla/líquido cefalorraquidiano , Esclerose Múltipla/imunologia , Membro 13 da Superfamília de Ligantes de Fatores de Necrose Tumoral/líquido cefalorraquidiano , Adulto , Idoso , Fator Ativador de Células B/análise , Fator Ativador de Células B/sangue , Linfócitos B/imunologia , Linfócitos B/metabolismo , Biomarcadores/análise , Biomarcadores/sangue , Biomarcadores/líquido cefalorraquidiano , Estudos de Casos e Controles , Sistema Nervoso Central/fisiopatologia , Feminino , Humanos , Imunidade Humoral/imunologia , Ativação Linfocitária/imunologia , Masculino , Pessoa de Meia-Idade , Esclerose Múltipla/fisiopatologia , Valor Preditivo dos Testes , Membro 13 da Superfamília de Ligantes de Fatores de Necrose Tumoral/análise , Membro 13 da Superfamília de Ligantes de Fatores de Necrose Tumoral/sangue , Regulação para Cima/imunologia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA