Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 1.959
Filtrar
1.
Clin Infect Dis ; 2019 Nov 22.
Artigo em Inglês | MEDLINE | ID: mdl-31754695

RESUMO

BACKGROUND: Some HCV-infected patients with sustained virological response (SVR) develops hepatic complications. Liver stiffness (LS) predicts clinical outcome in HIV-infected patients with active HCV coinfection, but information after SVR is lacking. We aimed to analyze the predictive ability of LS at SVR for liver complications in HIV/HCV-coinfected patients with advanced fibrosis treated with direct-acting antivirals (DAA). METHODS: 640 HIV/HCV-coinfected patients fulfilling the following criteria were included: i) Achieved SVR with DAA-including regimen; ii) LS ≥9.5 kPa before therapy and; iii) LS measurement available at SVR. The primary end-point was the occurrence of a liver complication -hepatic decompensation or hepatocellular carcinoma (HCC) - or requiring liver transplant after SVR. RESULTS: During a median (Q1-Q3) follow-up of 31.6 (22.7-36.6) months, 19 (3%) patients reached the primary end-point. In the multivariate analysis, variables (subhazard ratio [SHR] [95% CI]) associated with developing clinical outcomes were: prior hepatic decompensations (3.42 [1.28-9.12]), pre-treatment CPT class B or C (62.5 [3.08-1246.42]) and MELD scores (1.37 [1.03-1.82]), CPT class B or C at SVR (10.71 [1.32-87.01]), CD4 cell counts <200/µL at SVR time-point (4.42 [1.49-13.15]), FIB-4 index at SVR (1.39 [1.13-1.70]) and LS at SVR (1.05 [1.02-1.08] for 1 kPa increase). None out of 374 patients with LS <14kPa at SVR time-point developed a liver complication or required hepatic transplant. CONCLUSIONS: LS at the time of SVR after DAA therapy predicts the clinical outcome of HIV/HCV-coinfected patients with advanced fibrosis. These results suggest that LS measurement may be helpful to select candidates to be withdrawn from surveillance programs.

2.
J Fr Ophtalmol ; 2019 Nov 06.
Artigo em Inglês | MEDLINE | ID: mdl-31706462

RESUMO

PURPOSE: To prospectively analyse macular and optic disc changes after the occurrence of non-arteritic anterior ischemic optic neuropathy (NAION) and study possible predictors of final visual outcome. METHODS: Patients with NAION underwent a complete ophthalmic examination, including spectral-domain optical coherence tomography of the macula and optic nerve head. The examination was repeated 1, 3, 6, 9 and 12 months after onset. Final visual prognosis was evaluated by visual field (VF) and best-corrected visual acuity (BCVA) at the final visit. Data within the NAION group were analysed over the course of the disease and compared to a disease-free control group at each visit. RESULTS: Twenty-two eyes with NAION and 43 eyes from a control group were included. The retinal nerve fiber layer (RNFL) was significantly thicker in NAION eyes than controls at presentation (P=0.00), and significantly decreased during the next 3 months after presentation (P=0.02). The ganglion cell+inner plexiform layer (GCIPL) was thinner in the NAION group throughout the course of the disease (all P<0.05). Although the acute NAION eyes had significantly lower cup/disc ratios and higher neuroretinal and disc sizes (all P=0.00), there were no significant differences between groups from the third month onwards (all P>0.05). The best predictors of BCVA and VF were GCIPL at 3 months of follow-up (r2=0.32; P=0.03) and RNFL at 6 months of follow-up (r2=0.41; P=0.01) respectively. CONCLUSIONS: RNFL and optic disc changes occur during the first 3 months after the onset of NAION, whereas GCIPL is affected soon after the onset of symptoms. GCIPL and RNFL are useful predictors of final visual outcome.

3.
Comput Biol Med ; 114: 103466, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31568974

RESUMO

Dopamine has a major behavioral impact related to drug dependence, learning and memory functions, as well as pathologies such as schizophrenia and Parkinson's disease. Phasic release of dopamine can be measured in vivo with fast-scan cyclic voltammetry. However, even for a specialist, manual analysis of experiment results is a repetitive and time consuming task. This work aims to improve the automatic dopamine identification from fast-scan cyclic voltammetry data using convolutional neural networks (CNN). The best performance obtained in the experiments achieved an accuracy of 98.31% using a combined CNN approach. The end-to-end object detection system using YOLOv3 achieved an accuracy of 97.66%. Also, a new public dopamine release dataset was presented, and it is available at https://web.inf.ufpr.br/vri/databases/phasicdopaminerelease/.

5.
Cir. pediátr ; 32(4): 195-200, oct. 2019. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-ET2-2583

RESUMO

Objetivo. Estudio retrospectivo descriptivo de pacientes con en-fermedad de Hirschsprung (EH) intervenidos en nuestro centro por vía transanal. Material y métodos. Se seleccionaron a los pacientes con diagnóstico de EH intervenidos por vía transanal con sutura automática circular en nuestro centro entre los años 2006 y 2018. Se realizó biopsia laparoscópica de la zona previa a la dilatación en todos los casos. Tras la confirmación de la presencia de células, se procedió al descenso transanal tipo De la Torre hasta alcanzar la zona de la biopsia. La anastomosis se realizó con sutura automática circular (CEEA 21 o 25 mm). Resultados. Se intervinieron 21 pacientes, 16 niños y 5 niñas, con una mediana de edad de 12 meses (5-62). Ningún paciente presentó enterocolitis preoperatoria. La mediana de la longitud resecada fue de 14,5 cm (3-45), sin incidencias intraoperatorias. Un paciente (5%) presentó absceso rectosigmoideo postoperatorio, resuelto con antibióticos. Un caso (5%) necesitó de nueva cirugía por eventración del acceso umbilical. Un paciente (5%) presentó estenosis, resuelta mediante sección y otro (5%) compresión del manguito seromuscular, que fue tratada con sección laparoscópica. No hubo casos de enterocolitis postoperatoria. Tras una mediana de seguimiento de 97 meses (12-159), un niño presenta encopresis (5%) tratada mediante sistema de irrigaciones transanales periódicas y otro caso (5%) cursa con estreñimiento, en tratamiento con enemas periódicos. El resto se hallan asintomáticos. Conclusión. En definitiva, podemos afirmar que en nuestra serie el descenso transanal con sutura automática circular es una técnica segura y eficaz, que presenta una tasa baja de complicaciones intra y postoperatorias, con buenos resultados a largo plazo


Objective. Retrospective and descriptive study of patients with diagnosis of Hirschsprung disease (HD) in whom transanal pull-through was performed in our center. Material and methods. All patients with diagnosis of HD in whom transanal surgery was performed between 2006 and 2018 in our center were selected. In all cases laparoscopic biopsy was performed in the previous dilated area. Once intraoperatory biopsy revealed the presence of ganglionic cells, transanal De la Torre surgery was performed, until reaching the localization of the biopsied area. Circular automatic suture was performed in all cases. Results. Surgery was performed in 21 patients (16 boys and 5 girls) with a median age of 12 months (5-62). No patient had enterocolitis. The median resection length was 14.5 cm (3-45) and no intraoperative complications happened. One patient (5%) developed a rectosigmoideal abscess, which was solved with antibiotic. One case (5%) needed another surgery due to umbilical trochar eventration. No patient had enterocolitis after the surgery. One patient (5%) had stenosis, solved by its section and other case (5%) had sleeve compres-sion which was solved by laparoscopic section. After a median follow up of 97 months (12-159), one child (5%) developed encopresis, which is treated with periodic anal irrigations and other patient (5%) has chronic constipation, which require periodic enemas. The rest of the patients have no symptomatology. Conclusion. In conclusion, in our series of cases, transanal pull-through with circular automatic suture was a safe and useful technique. It has a low rate of operative and postoperative complications and provides good prospective results


Assuntos
Humanos , Masculino , Feminino , Lactente , Pré-Escolar , Doença de Hirschsprung/diagnóstico , Doença de Hirschsprung/cirurgia , Cirurgia Endoscópica Transanal/instrumentação , Técnicas de Sutura , Anastomose Cirúrgica/métodos , Cirurgia Endoscópica Transanal/métodos , Malformações Anorretais/cirurgia , Biópsia
6.
Cir Pediatr ; 32(4): 195-200, 2019 Oct 01.
Artigo em Espanhol | MEDLINE | ID: mdl-31626405

RESUMO

OBJECTIVE: Retrospective and descriptive study of patients with diagnosis of Hirschsprung disease (HD) in whom transanal pull-through was performed in our center. MATERIAL AND METHODS: All patients with diagnosis of HD in whom transanal surgery was performed between 2006 and 2018 in our center were selected. In all cases laparoscopic biopsy was performed in the previous dilated area. Once intraoperatory biopsy revealed the presence of ganglionic cells, transanal De la Torre surgery was performed, until reaching the localization of the biopsied area. Circular automatic suture was performed in all cases. RESULTS: Surgery was performed in 21 patients (16 boys and 5 girls) with a median age of 12 months (5-62). No patient had enterocolitis. The median resection length was 14.5 cm (3-45) and no intraoperative complications happened. One patient (5%) developed a rectosigmoideal abscess, which was solved with antibiotic. One case (5%) needed another surgery due to umbilical trochar eventration. No patient had enterocolitis after the surgery. One patient (5%) had stenosis, solved by its section and other case (5%) had sleeve compression which was solved by laparoscopic section. After a median follow up of 97 months (12-159), one child (5%) developed encopresis, which is treated with periodic anal irrigations and other patient (5%) has chronic constipation, which require periodic enemas. The rest of the patients have no symptomatology. CONCLUSION: In conclusion, in our series of cases, transanal pull-through with circular automatic suture was a safe and useful technique. It has a low rate of operative and postoperative complications and provides good prospective results.

7.
Chemosphere ; 241: 125009, 2019 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-31597109

RESUMO

Iron (III) was incorporated, to the surface of a synthesized ZnO, using two nominal molar percentages of Fe (III): 1% and 5% Fe relative to ZnO. Samples dried and calcined at 200 °C and 400 °C for 2 h, were characterized by XRD, XPS, XRF, N2-adsorption-BET and (UV-vis)-DRS. Photocatalytic activities of the catalysts were assessed based on the degradation of rhodamine B (RhB) and caffeine (CAF) in aqueous solution under two irradiation conditions: UV and visible light illumination. Prior to the photocatalytic tests, the interaction of each one of the substrates with either Fe(III) or Fe(II) was studied in homogeneous medium under UV-illumination and oxygenated environment. It was found that Fe (III) can play an important role in homogeneous media in the photoassisted degradation, both of rhodamine B and caffeine, while Fe (II) does not exert a relevant role in the photoassisted degradation of the referred substrates. Fe-ZnO samples display similar or poorer performance than pure ZnO in the presence of UV light for both studied substrates. The phenomenon can be attributed to the formation of either goethite or ZnFe2O4 at the ZnO surface where the coupled Fe3+/Fe2+ can act as recombination centers for the photogenerated charges. On the contrary, all Fe-ZnO samples showed enhanced photocatalytic activity under visible illumination which seems to be independent of the iron content. In this context, the mechanisms for photoassisted degradation of both the substrates in homogeneous medium and photocatalytic degradation are discussed, as well as the role of Fe in the photodegradation processes.

9.
Rehabilitación (Madr., Ed. impr.) ; 53(3): 211-213, jul.-sept. 2019.
Artigo em Espanhol | LILACS-Express | ID: ibc-ET1-3747

RESUMO

La malformación de Dandy Walker se define por hipoplasia del vermis cerebeloso y dilatación quística del cuarto ventrículo. Algunas de las manifestaciones clínicas son hidrocefalia, retraso en el desarrollo motor, hipotonía y ataxia. El objetivo del tratamiento es mejorar el funcionamiento general del individuo y proporcionar una mejor calidad de vida a través de un equipo multidisciplinario. En el presente caso clínico se describe la evolución de un paciente diagnosticado con malformación de Dandy Walker tras la intervención del modelo médico del Centro de Rehabilitación e Inclusión Infantil Teletón Guanajuato (CRIT) el cual se centra en la rehabilitación del paciente y la familia, cubriendo cada una de las áreas que engloban al paciente


Dandy-Walker malformation is characterised by hypoplasia of the cerebellar vermis and cystic dilation of the fourth ventricle. Some of the clinical manifestations of this malformation are hydrocephalus, delayed motor development, hypotonia, and ataxia. Treatment aims to improve the individual's overall functioning and enhance quality of life through a multidisciplinary team. This case report describes the outcome of a patient diagnosed with Dandy-Walker malformation, after the intervention of the medical model at Centro de Rehabilitación e Inclusión Infantil Teletón Guanajuato (CRIT), which focuses on rehabilitating the patient and the family, covering each of the areas encompassing the patient

10.
J Nutr Health Aging ; 23(8): 710-716, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31560028

RESUMO

OBJECTIVES: To assess the 3-month impact on physical function of a program for community-dwelling frail older adults, based on the integration of primary care, geriatric medicine, and community resources, implemented in "real life". DESIGN: Interventional cohort study. SETTING: Primary care in Barcelona, Spain. PARTICIPANTS: Individuals aged ≥80 years (n=134), presenting at least one sign of frailty (i.e., slow gait speed, weakness, memory complaints, involuntary weight loss, poor social support). INTERVENTION: After frailty screening by the primary care team, candidates were referred to a geriatric team (geriatrician + physical therapist), who performed a comprehensive geriatric assessment and designed a tailored multidisciplinary intervention in the community, including a) multi-modal physical activity (PA) sessions, b) promotion of adherence to a Mediterranean diet c) health education and d) medication review. MEASUREMENTS: Participants were assessed based on a comprehensive geriatric assessment including physical performance (Short Physical Performance Battery -SPPB- and gait speed), at baseline and at a three month follow-up. RESULTS: A total of 112 (83.6%) participants (mean age=80.8 years, 67.9% women) were included in this research. Despite being independent in daily life, participants' physical performance was impaired (SPPB=7.5, SD=2.1, gait speed=0.71, SD=0.20 m/sec). After three months, 90.2% of participants completed ≥7.5 physical activity sessions. The mean improvements were +1.47 (SD 1.64) points (p<0.001) for SPPB, +0.08 (SD 0.13) m/sec (p<0.001) for gait speed, -5.5 (SD 12.10) sec (p<0.001) for chair stand test, and 53% (p<0.001) improved their balance. Results remained substantially unchanged after stratifying the analyses according to the severity of frailty. CONCLUSIONS: Our results suggested that a "real-world" multidisciplinary intervention, integrating primary care, geriatric care, and community services may improve physical function, a marker of frailty, within 3 months. Further studies are needed to address the long-term impact and scalability of this implementation program.

12.
Fisioterapia (Madr., Ed. impr.) ; 41(4): 213-218, jul.-ago. 2019. tab
Artigo em Espanhol | IBECS | ID: ibc-183098

RESUMO

Antecedentes y objetivo: La medición de la movilidad torácica tiene importancia en la valoración clínica de niños con afecciones del sistema respiratorio; sin embargo, se sabe que los valores pueden cambiar de acuerdo con las características de la población de cada país. El objetivo del estudio fue describir los valores de la movilidad torácica en niños colombianos. Materiales y métodos: Estudio descriptivo transversal realizado en 2colegios de la ciudad de Cali (Colombia) mediante un muestreo aleatorizado simple con asignación proporcional por grupo etario. Se evaluó la movilidad torácica con cirtometría y se tomaron las medidas antropométricas peso, talla e IMC para la edad. Resultados: Se incluyó a 79 niños y 72 niñas que, en su mayoría, tuvieron un IMC normal para la edad (62,3%). Los promedios de cirtometría axilar y xifoidea fueron 4,3±1,1cm y 4,1±1,1cm respectivamente. Los niños de 11años tuvieron una cirtometría axilar mayor que las niñas de esa misma edad (4,3±0,5 vs. 3,7±0,9; p =0,006). En las niñas, la cirtometría axilar desciende a medida que aumenta la edad (p=0,040). Conclusiones: En las edades estudiadas la movilidad torácica difiere entre niños y niñas, probablemente porque el desarrollo de la composición corporal varía durante la pubertad y es diferencial por sexo


Background and objective: Although the measurement of thoracic mobility is important in the clinical assessment of children with respiratory system disorders, it is known that the values can change according to the characteristics of the population of each country. The aim of the study was to report the thoracic mobility values in healthy Colombian children between 8 and 11 years old. Materials and methods: Cross-sectional descriptive study carried out in 2schools in the city of Cali, Colombia, using simple random sampling with proportional allocation by age group. The thoracic mobility was measured with cirtometry (measurement of circumferences), and the anthropometric measurements recorded for weight, height, and BMI-for-age. Results: A total of 79 boys and 72 girls were included. Most of them had a normal BMI-for-age (62.3%), with mean axillary and xiphoid cirtometry being 4.3±1.1cm and 4.1±1.1cm, respectively. Eleven-year-old boys had a higher axillary cirtometry than girls of the same age (4.3±0.5 vs. 3.7±0.9, p=.006). In girls, axillary cirtometry decreased as age increased (p=.040). Conclusions: At the ages studied, thoracic mobility differs between boys and girls, probably because the development of body composition varies during puberty and is differentiated by gender


Assuntos
Humanos , Masculino , Feminino , Criança , Composição Corporal/fisiologia , Pesos e Medidas Corporais/métodos , Parede Torácica/fisiologia , Fenômenos Fisiológicos Respiratórios , Antropometria , Índice de Massa Corporal , Estudos Transversais , Colômbia , Análise de Dados , Análise de Variância
13.
Rehabilitacion (Madr) ; 53(3): 211-213, 2019.
Artigo em Espanhol | MEDLINE | ID: mdl-31370948

RESUMO

Dandy-Walker malformation is characterised by hypoplasia of the cerebellar vermis and cystic dilation of the fourth ventricle. Some of the clinical manifestations of this malformation are hydrocephalus, delayed motor development, hypotonia, and ataxia. Treatment aims to improve the individual's overall functioning and enhance quality of life through a multidisciplinary team. This case report describes the outcome of a patient diagnosed with Dandy-Walker malformation, after the intervention of the medical model at Centro de Rehabilitación e Inclusión Infantil Teletón Guanajuato (CRIT), which focuses on rehabilitating the patient and the family, covering each of the areas encompassing the patient.

14.
Clin Biochem ; 71: 69-71, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31299317

RESUMO

We report two cases of hemoglobin Sendagi in a Romanian family residing in Spain: a four-year-old boy and his mother, who had been previously diagnosed with another type of congenital hemolytic anemia and had undergone splenectomy in her country during childhood. The unstable hemoglobin variant, hemoglobin Sendagi, is characterized by decreased oxygen affinity caused by replacement of one of the critical amino acid residues, phenylalanine beta 42 (CD1) of the beta-chain, with valine in the heme pocket, resulting in methemoglobin formation. As a result of migratory movements in Europe, new disease-causing hemoglobin variants are emerging in our country. Here, capillary electrophoresis enabled the identification of the variant and a molecular study was used to establish an accurate diagnosis.


Assuntos
Eletroforese Capilar/métodos , Hemoglobinas Anormais/metabolismo , Mutação , Adulto , Pré-Escolar , Feminino , Humanos , Masculino
15.
Behav Brain Res ; 373: 112085, 2019 Nov 05.
Artigo em Inglês | MEDLINE | ID: mdl-31319133

RESUMO

Alcohol exposure is linked to behavioral flexibility deficits in humans, but it is unclear when the critical exposure occurred or if alcohol exposure alone is sufficient to produce behavior deficits. Increasing evidence shows that binge levels of alcohol during adolescence are particularly harmful to the brain, producing physiological and behavioral effects that can persist into adulthood. The present study determined whether adolescent intermittent ethanol (AIE) in rats impaired action selection in a discriminative stimulus task using a foraging response. Rats were exposed to ethanol during adolescence (5 g/kg/day, IG, 2-days-on/2-days-off, postnatal day 25-54). In adulthood, they learned to dig for food reward buried in one of two media, cued with one of two odors. AIE and control rats both learned to discriminate between olfactory cues, but AIE rats were impaired when reversing that learned association (first intra-dimensional reversal). However, AIE rats were faster to reinstate the original odor discrimination rule (second reversal), suggesting perseverative behavior. Next, the reward location was cued by digging media rather than odor. Both groups learned this extra-dimensional shift; however, control rats were slower to reach criterion. These findings are consistent with studies of people with substance abuse disorder, who learn new stimulus-response associations similarly to, or better than, control subjects, but perseverate when attempting to replace a well-learned association. These data suggest that adolescent binge-alcohol exposure contributes to behavioral flexibility deficits observed in adulthood.

17.
Rev Neurol ; 69(4): 135-144, 2019 Aug 16.
Artigo em Espanhol | MEDLINE | ID: mdl-31334556

RESUMO

INTRODUCTION: Spinal cord injury is a complex and life-disrupting condition. The functional recovery of the upper limb has been considered as an important objective in tetraplegia because it improves significantly the quality of living in these patients. Virtual reality is a new emerging tool of rehabilitation in spinal cord injured patients. AIM: To carry out a systematic review about the information about the application of these systems in spinal cord injury in the rehabilitation of the upper limb. PATIENTS AND METHODS: This review includes clinical trials dated until April 2018, which investigate the functional recovery of the upper limb through virtual reality systems in patients with complete or incomplete tetraplegia. The following databases were used to search for those clinical trials: Scopus, Web of Science, PubMed, Medline Complete, Science Direct, CINHAL and Brain. RESULTS: Five articles were selected for this review, including randomized clinical trials and clinical trials. The main results show a good tendency on the functional recovery with the combination of virtual reality systems and conventional therapy. CONCLUSIONS: The main limitations and the low quality of the studies show the necessity of further investigations with this new tool of rehabilitation. However, the incorporation of virtual reality systems as a rehabilitation supplement might be a beneficial tool on the functional recovery in spinal cord injury.

18.
Rev Neurol ; 68(10): 401-408, 2019 May 16.
Artigo em Espanhol | MEDLINE | ID: mdl-31070231

RESUMO

INTRODUCTION: There have been studies in which contralesional inhibitory and ipsilesional excitatory transcranial magnetic stimulation (TMS) has been used as coadjuvant therapy in the motor rehabilitation of the thoracic limb in patients. However, there is no consensus regarding the stimulation variables or their clinical outcomes. AIM: To describe the results of clinical trials where TMS has been applied in rehabilitation in patients with cerebrovascular disease (CVD). PATIENTS AND METHODS: A systematic review of the PubMed database was performed. The articles cataloged as originals in English, whose population had limitation of thoracic limb after CVD were selected. Pilot studies, as well as studies in which patients under pharmacological treatment included any intervention other than physical or occupational therapy were excluded. Given their heterogeneity, it was not possible to apply inferential statistics, only descriptive statistics were use. RESULTS: Seven studies were identified; 259 cases with an age of 64.3 ± 4.28 years (range: 35-89 years) were reported. The TMS protocols, for the most part, were performed by contralesional inhibitory type stimulation. There were positive results in five studies. CONCLUSION: In accordance with the results obtained, we observed that TMS could contribute to the improvement of motor control of the thoracic limb in patients with sequelae due to CVD.

19.
Clin Nutr ; 2019 Apr 20.
Artigo em Inglês | MEDLINE | ID: mdl-31053509

RESUMO

BACKGROUND & AIMS: Little is known about the impact of specific dietary patterns on the development of obesity phenotypes. We aimed to determine the association of longitudinal changes in adherence to the traditional Mediterranean diet (MedDiet) with the transition between different obesity phenotypes. METHODS: Data of 5801 older men and women at high cardiovascular risk from PREDIMED trial were used. Adherence to MedDiet was measured with the validated 14p-Mediterranean Diet Adherence Screener (MEDAS). Using the simultaneous combination of metabolic health- and body size-related parameters participants were categorized into one of four phenotypes: metabolically healthy and abnormal obese (MHO and MAO), metabolically healthy and abnormal non-obese (MHNO and MANO). Cox regression models with yearly repeated measures during 5-year of follow-up were built with use of Markov chain assumption. RESULTS: Each 2-point increase in MEDAS was associated with the following transitions: in MAO participants, with a 16% (95% CI 3-31%) greater likelihood of becoming MHO; in MHO participants with a 14% (3-23%) lower risk of becoming MAO; in MHNO participants with a 18% (5-30%) lower risk of becoming MHO. In MANO women, but not in men, MEDAS was associated with 20% (5-38%) greater likely of becoming MHNO (p for interaction by gender 0.014). No other significant associations were observed. CONCLUSIONS: Better adherence to the traditional MedDiet is associated with transitions to healthier phenotypes, promoting metabolic health improvement in MAO, MANO (only in women), and MHO, as well as protecting against obesity incidence in MHNO subjects.

20.
Neurología (Barc., Ed. impr.) ; 34(4): 241-247, mayo 2019. tab
Artigo em Espanhol | IBECS | ID: ibc-180814

RESUMO

Introducción: El examen de la sensibilidad al contraste permite determinar la calidad de la función visual en pacientes con esclerosis múltiple (EM). El objetivo de este estudio es analizar las modificaciones evolutivas de la función visual en pacientes con EM remitente-recurrente. Métodos: Estudio longitudinal de 61 pacientes clasificados en 3 grupos: a) pacientes libres de enfermedad (grupo control); b) pacientes con EM y sin antecedentes de neuritis óptica (NO), y c) pacientes con EM y antecedentes de NO unilateral. A todos los pacientes se les realizó una exploración oftalmológica que incluía agudeza visual y test de sensibilidad al contraste tipo Pelli-Robson mono y binocularmente, tanto al inicio como a los 6 años de seguimiento. Resultados: La sensibilidad al contraste monocular en pacientes con EM con y sin antecedentes de NO fue significativamente inferior al grupo control tanto al inicio (p=0,00 y p=0,01) como a los 6 años (p = 0,01 y p = 0,02), manteniéndose estable a lo largo del seguimiento excepto en el grupo de pacientes con NO en el cual existe una pérdida significativa de sensibilidad al contraste (p = 0,01). La agudeza visual y la sensibilidad al contraste binocular al inicio y a los 6 años de seguimiento fueron significativamente inferiores en el grupo de pacientes con antecedentes de NO que en el grupo control (p = 0,003 y p = 0,002; p = 0,006 y p = 0,005) y con EM sin NO (p = 0,04 y p = 0,038; p = 0,008 y p = 0,01); sin embargo, no encontramos diferencias significativas en el seguimiento (p = 0,1 y p = 0,5). Conclusiones: El test de Pelli-Robson monocular podría servir como marcador evolutivo del deterioro de la función visual en ojos con NO


Introduction: The contrast sensitivity test determines the quality of visual function in patients with multiple sclerosis (MS). The purpose of this study is to analyse changes in visual function in patients with relapsing-remitting MS with and without a history of optic neuritis (ON). Methods: We conducted a longitudinal study including 61 patients classified into 3 groups as follows: a) disease-free patients (control group); b) patients with MS and no history of ON; and c) patients with MS and a history of unilateral ON. All patients underwent baseline and 6-year follow-up ophthalmologic examinations, which included visual acuity and monocular and binocular Pelli-Robson contrast sensitivity tests. Results: Monocular contrast sensitivity was significantly lower in MS patients with and without a history of ON than in controls both at baseline (P=.00 and P=.01, respectively) and at 6 years (P=.01 and P=.02). Patients with MS and no history of ON remained stable throughout follow-up whereas those with a history of ON displayed a significant loss of contrast sensitivity (P=.01). Visual acuity and binocular contrast sensitivity at baseline and at 6 years was significantly lower in the group of patients with a history of ON than in the control group (P=.003 and P=.002 vs P=.006 and P=.005) and the group with no history of ON (P=.04 and P=.038 vs P=.008 and P=.01). However, no significant differences were found in follow-up results (P=.1 and P=.5). Conclusions: Monocular Pelli-Robson contrast sensitivity test may be used to detect changes in visual function in patients with ON


Assuntos
Humanos , Masculino , Feminino , Adulto , Esclerose Múltipla Recidivante-Remitente/complicações , Neurite Óptica/epidemiologia , Acuidade Visual/fisiologia , Seleção Visual/métodos , Sensibilidades de Contraste/fisiologia , Estudos Longitudinais , Testes Visuais/estatística & dados numéricos , Estudos de Casos e Controles
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA