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Medicine (Baltimore) ; 99(20): e20243, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32443361


BACKGROUND: Previous studies have reported that cuff-assisted colonoscopy (CAC) can be used for detection of adenoma (DA). However, there are inconsistent results regarding the CAC for DA. Thus, this study will systematically explore the impact of CAC for DA. METHODS: In order to retrieve potential eligible articles, this study will identify the following electronic databases from their inceptions to present: MEDLINE, EMBASE, Cochrane Library, PSYCINFO, Web of Science, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure. All electronic databases will be searched without any language limitation. We will consider case-controlled studies that focused on exploring the impacts of CAC for DA. Two authors will perform study selection, information collection and risk of bias assessment, respectively. Any discrepancies between 2 authors will be resolved through discussion with a third author. RESULTS: This study will summarize the most recent evidence to assess the impact of CAC for DA. CONCLUSION: The findings of this study will provide evidence of CAC for DA in clinical practice. SYSTEMATIC REVIEW REGISTRATION: INPLASY202040042.

Adenoma/diagnóstico , Colonoscopia/métodos , Adenoma/fisiopatologia , Protocolos Clínicos , Colonoscopia/normas , Colonoscopia/tendências , Neoplasias Colorretais/diagnóstico , Neoplasias Colorretais/fisiopatologia , Detecção Precoce de Câncer/métodos , Detecção Precoce de Câncer/normas , Detecção Precoce de Câncer/tendências , Humanos , Metanálise como Assunto
Chin J Cancer ; 32(11): 624-8, 2013 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-23668927


Paraganglioma is a rare neuroendocrine neoplasm observed in patients of all ages, with an estimated incidence of 3/1,000,000 population. It has long been recognized that some cases are familial. The majority of these tumors are benign, and the only absolute criterion for malignancy is the presence of metastases at sites where chromaffin tissue is not usually found. Some tumors show gross local invasion and recurrence, which may indeed kill the patient, but this does not necessarily associate with metastatic potential. Here, we report a case of vertebral metastatic paraganglioma that occurred 19 months after the patient had undergone partial cystectomy for urinary bladder paraganglioma. We believe this to be a rarely reported bone metastasis of paraganglioma arising originally within the urinary bladder. In this report, we also provide a summary of the general characteristics of this disease, together with progress in diagnosis, treatment, and prognosis.

Paraganglioma , Neoplasias da Coluna Vertebral/secundário , Vértebras Torácicas , Neoplasias da Bexiga Urinária , Cromogranina A/metabolismo , Cistectomia , Feminino , Humanos , Pessoa de Meia-Idade , Paraganglioma/metabolismo , Paraganglioma/patologia , Paraganglioma/secundário , Paraganglioma/cirurgia , Fosfopiruvato Hidratase/metabolismo , Prognóstico , Cintilografia , Neoplasias da Coluna Vertebral/diagnóstico por imagem , Neoplasias da Coluna Vertebral/cirurgia , Sinaptofisina/metabolismo , Tecnécio , Tomografia Computadorizada por Raios X , Neoplasias da Bexiga Urinária/metabolismo , Neoplasias da Bexiga Urinária/patologia , Neoplasias da Bexiga Urinária/cirurgia
Zhonghua Zhong Liu Za Zhi ; 28(8): 583-5, 2006 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-17236551


OBJECTIVE: To explore the feasibility of transfecting DHFR (human double-mutant dihydrofolate reductase) gene into mouse bone marrow cells and the effect of resistance to high dose MTX chemotherapy. METHODS: After DHFR gene was transfected into mouse bone marrow cells with retroviral vector, the cells were treated with methotrexate (MTX) and then CFU-GM (granulocyte-macrophage colony-forming unit) assay was performed. Peripheral blood leucocytes and platelets, body weight and survival rate were observed. After treatment with high dose MTX, the expression of drug resistance gene was checked by RT-PCR in the transfected bone marrow cells. RESULTS: SFG-F/S-NeoR gene-transfected mice bone marrow cells yielded drug-resistance colonies to MTX (donor mice: 15.8%, recipient mice: 18.0%, control: 0) The peripheral blood leucocytes and platelets, body weight recovered gradually and the survival rate was 83.3% at the 40th day, while 0 in controls in gene transfected mice after large dose MTX treatment. RT-PCR of transgenic mouse marrow cells showed the band of F/S gene (400 bp). CONCLUSION: DHFR gene can not only be integrated and expressed in bone marrow cells but also improve their drug-resistence to MTX.

Células da Medula Óssea/efeitos dos fármacos , Metotrexato/farmacologia , Mutação , Tetra-Hidrofolato Desidrogenase/genética , Animais , Antimetabólitos Antineoplásicos/farmacologia , Células da Medula Óssea/citologia , Células da Medula Óssea/metabolismo , Transplante de Medula Óssea , Células Cultivadas , Resistencia a Medicamentos Antineoplásicos/genética , Contagem de Eritrócitos , Vetores Genéticos , Contagem de Leucócitos , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Retroviridae/genética , Análise de Sobrevida , Tetra-Hidrofolato Desidrogenase/metabolismo , Transfecção