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2.
Trials ; 22(1): 566, 2021 Aug 26.
Artigo em Inglês | MEDLINE | ID: mdl-34521466

RESUMO

BACKGROUND: Non-alcohol fatty liver disease (NAFLD) is the most common chronic liver disease in the world, with a high incidence and no effective treatment. At present, the targeted therapy of intestinal microbes for NAFLD is highly valued. Lycium barbarum polysaccharide (LBP), as the main active ingredient of Lycium barbarum, is considered to be a new type of prebiotic substance, which can improve NAFLD by regulating the gut microbiota. The purpose of this study is to evaluate the safety and efficacy of LBP supplementation in modulating gut microbiota for NAFLD patients. METHODS: This randomized, double-blind, placebo-control study will be conducted in the physical examination center of the Ningxia Hui Autonomous Region People's Hospital. A total of 50 patients with NAFLD confirmed by abdominal ultrasound, laboratory tests, and questionnaire surveys will be recruited and randomly assigned into the control group (maltodextrin placebo capsules) and the intervention group (LBP supplementation capsules) for 3 months. Neither patients, nor investigators, nor data collectors will know the contents in each capsule and the randomization list. The primary outcome measure is the level of ALT concentration relief after the intervention. Secondary outcomes include gut microbiota abundance and diversity, intestinal permeability, patient's characteristic demographic data and body composition, adverse effects, and compliance from patients. DISCUSSION: LBPs are potential prebiotics with the property of regulating host gut microbiota. Our previous studies have documented that LBP supplement can improve the liver damage and the gut microflora dysbiosis in NAFLD rats. This treatment would provide a more in-depth understanding of the effect of this LBP supplementation. TRIAL REGISTRATION: Chinese Clinical Trial Register, ChiCTR2000034740 . Registered on 17 July 2020.


Assuntos
Medicamentos de Ervas Chinesas , Microbioma Gastrointestinal , Hepatopatia Gordurosa não Alcoólica , Animais , Suplementos Nutricionais , Medicamentos de Ervas Chinesas/efeitos adversos , Humanos , Hepatopatia Gordurosa não Alcoólica/diagnóstico , Hepatopatia Gordurosa não Alcoólica/tratamento farmacológico , Ensaios Clínicos Controlados Aleatórios como Assunto , Ratos
3.
Int J Biol Macromol ; 183: 1379-1392, 2021 Jul 31.
Artigo em Inglês | MEDLINE | ID: mdl-33992651

RESUMO

Gut microbiota and intestinal permeability have been demonstrated to be the key players in the gut-liver cross talk in nonalcoholic fatty liver disease (NAFLD). Lycium barbarum polysaccharides (LBPs), which seem to be a potential prebiotic, and aerobic exercise (AE) have shown protective effects on NAFLD. However, their combined effects on intestinal microecology remain unclear. This study evaluated the effects of LBP, AE, and its combination (LBP + AE) on gut microbiota composition, intestinal barrier, and hepatic inflammation in NAFLD. LBP + AE showed high abundance and diversity of gut microbiota, restored the gut microbiota composition, increased some Bacteroidetes, short chain fatty acids, but decreased Proteobacteria and the ratio of Firmicutes/Bacteroidetes. Simultaneously, LBP, AE, and LBP + AE could restore the colonic and ileum tight junctions by increasing the expression of zonula occludens-1 and occludin. They also downregulated gut-derived lipopolysaccharides (LPSs), hepatic LPS-binding proteins, inflammatory factors, and related indicators of the LPS/TLR4/NF-κB signaling pathway for the liver. Our results implied that LBP could be considered a prebiotic agent, and LBP + AE might be a promising treatment for NAFLD because it could maintain gut microbiota balance, thereby restoring intestinal barrier and exerting hepatic benefits.


Assuntos
Medicamentos de Ervas Chinesas/uso terapêutico , Hepatopatia Gordurosa não Alcoólica/tratamento farmacológico , Hepatopatia Gordurosa não Alcoólica/terapia , Condicionamento Físico Animal/métodos , Animais , Microbioma Gastrointestinal/efeitos dos fármacos , Inflamação/tratamento farmacológico , Inflamação/microbiologia , Inflamação/terapia , Mucosa Intestinal/efeitos dos fármacos , Fígado/efeitos dos fármacos , Fígado/imunologia , Hepatopatia Gordurosa não Alcoólica/microbiologia , Prebióticos
4.
Trials ; 22(1): 29, 2021 Jan 06.
Artigo em Inglês | MEDLINE | ID: mdl-33407845

RESUMO

BACKGROUND: The pain management of postherpetic neuralgia (PHN) remains a major challenge, with no immediate relief. Nitrous oxide/oxygen mixture has the advantages of quick analgesic effect and well-tolerated. The purpose of this study is to investigate the analgesic effect and safety of nitrous oxide/oxygen mixture in patients with PHN. METHODS/DESIGN: This study is a single-center, two-group (1:1), randomized, placebo-controlled, double-blind clinical trial. A total of 42 patients with postherpetic neuralgia will be recruited and randomly divided into the intervention group and the control group. The control group will receive routine treatment plus oxygen, and the intervention group will receive routine treatment plus nitrous oxide/oxygen mixture. Data collectors, patients, and clinicians are all blind to the therapy. The outcomes of each group will be monitored at baseline (T0), 5 min (T1), and 15 min (T2) after the start of the therapy and at 5 min after the end of the therapy (T3). The primary outcome measure will be the pain intensity. Secondary outcomes included physiological parameters, adverse effects, patients' acceptance of analgesia, and satisfaction from patients. DISCUSSION: Previous studies have shown that nitrous oxide/oxygen mixture can effectively relieve cancer patients with breakthrough pain. This study will explore the analgesic effect of oxide/oxygen mixture on PHN. If beneficial to patients with PHN, it will contribute to the pain management of PHN. TRIAL REGISTRATION: Chinese Clinical Trial Register ChiCTR1900023730 . Registered on 9 June 2019.


Assuntos
Neuralgia Pós-Herpética , Óxido Nitroso , Analgésicos/efeitos adversos , Método Duplo-Cego , Humanos , Neuralgia Pós-Herpética/diagnóstico , Neuralgia Pós-Herpética/tratamento farmacológico , Óxido Nitroso/efeitos adversos , Oxigênio , Medição da Dor , Ensaios Clínicos Controlados Aleatórios como Assunto , Resultado do Tratamento
5.
J Adv Nurs ; 76(12): 3623-3630, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-32951241

RESUMO

AIM: This study aims to evaluate the safety and analgesic efficacy of pre-mixed nitrous oxide/oxygen mixture treatment of pain induced by dressing change for perianal abscess. DESIGN: This protocol is a randomized, double-blind, placebo-controlled trial. METHODS: This study will be implemented in the Hospital of Traditional Chinese Medicine. Subjects enrolled in this study are hospitalized patients who suffered from moderate to severe pain due to dressing change after incision and drainage. Two hundred patients will be selected and randomly assigned to either an intervention or a control group. The intervention group will get routine pain treatment plus pre-mixed nitrous oxide/oxygen mixture treatment and the control group will be treated with routine pain management plus medical air treatment. All these patients, medical staff and investigators are blind to the nature of the gas in each cylinder, which is randomized. Data will be collected at baseline (T0), 5 min (T1) after the starting of intervention and 5 min post intervention (T2) for each group. The primary outcome is the level of pain relief at T1 and T2. The secondary outcomes cover physiological parameters, adverse events, satisfaction of patients and health professionals and the acceptance from patients. DISCUSSION: Results of this study will be discussed and the safety and effect of nitrous oxide/oxygen treatment of pain induced by dressing change will be proven. IMPACT: When the finding of this study has an active effect on the treatment of pain caused by dressing change, it may provide more options for nursing staff to choose nurse-led analgesia techniques and then improving the level and quality of pain care as well as patients' overall satisfaction with the Anorectal Department in China.


Assuntos
Abscesso , Óxido Nitroso , Abscesso/terapia , Bandagens , China , Método Duplo-Cego , Humanos , Oxigênio , Dor/tratamento farmacológico , Dor/etiologia , Medição da Dor , Ensaios Clínicos Controlados Aleatórios como Assunto , Resultado do Tratamento
6.
J Zhejiang Univ Sci B ; 21(8): 668-672, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32748582

RESUMO

In December 2019, coronavirus disease 2019 (COVID-19), a new de novo infectious disease, was first identified in Wuhan, China and quickly spread across China and around the world. The etiology was a novel betacoronavirus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Lu et al., 2020). On Mar. 11, 2020, World Health Organization (WHO) characterized COVID-19 as a global pandemic. As of Mar. 22, 2020, over 292 000 confirmed COVID-19 cases have been reported globally. To date, COVID-19, with its high infectivity, has killed more people than severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) combined (Wu and McGoogan, 2020).


Assuntos
Infecções por Coronavirus/diagnóstico por imagem , Pneumonia Viral/diagnóstico por imagem , Radiografia Torácica , Tomografia Computadorizada por Raios X , Adulto , Betacoronavirus , COVID-19 , Teste para COVID-19 , China , Técnicas de Laboratório Clínico , Infecções por Coronavirus/diagnóstico , Feminino , Febre/virologia , Humanos , Contagem de Linfócitos , Masculino , Pessoa de Meia-Idade , Pandemias , SARS-CoV-2 , Resultado do Tratamento
7.
Dalton Trans ; 49(22): 7488-7495, 2020 Jun 14.
Artigo em Inglês | MEDLINE | ID: mdl-32441289

RESUMO

A two-dimensional Cd(ii) metal-organic framework (MOF) was constructed from a tris(pyridinium)-based hexacarboxylate zwitterionic ligand. The MOF shows a novel fashion of 2-fold 2D → 2D parallel entanglement. It is the entanglement that dictates close interlayer contacts between carboxylate (electron donor) and pyridinium (acceptor), which in turn impart the MOF with reversible photochromic properties through photoinduced electron transfer (PET). This is an extension of PET-based photochromism from bipyridinium to multipyridinium compounds. Thanks to the photoresponsive behaviour, the fluorescence of the MOF can be reversibly modulated or switched by photoirradiation. Besides, the fluorescence of the water-stable MOF in aqueous dispersion is very sensitive to nitrofuran antibiotics with high selectivity, and therefore the MOF is a good candidate of efficient and regenerable sensing material for determination of the antibiotics in water media.


Assuntos
Antibacterianos/análise , Corantes Fluorescentes/química , Estruturas Metalorgânicas/química , Nitrofuranos/análise , Compostos de Piridínio/química , Corantes Fluorescentes/síntese química , Estruturas Metalorgânicas/síntese química , Processos Fotoquímicos , Compostos de Piridínio/síntese química , Espectrometria de Fluorescência
8.
Trials ; 21(1): 102, 2020 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-31959220

RESUMO

BACKGROUND: Hysterosalpingography (HSG) is an accepted radiologic diagnostic modality for initial infertility workup, and is generally considered uncomfortable and painful. However, the management of pain related to HSG remains inefficient. As an emerging nonpharmacologic and noninvasive pain control strategy, virtual reality (VR) distraction has been successfully used in areas such as burns, blunt force trauma, hospital-based needle procedures, dental/periodontal procedures, and urological endoscopy patients. This study aims to evaluate the analgesic effect of VR during HSG. METHODS/DESIGN: A single-center, parallel-group, randomized controlled trial will be carried out in the Radiology Department of Yinchuan Women and Children Healthcare Hospital, Yinchuan. A total of 200 participants who are scheduled for HSG will be enrolled in this study. The participants will be randomized (1:1) into two groups: a VR group and a blank control group. The VR group will receive routine care plus immersive VR intervention and the blank control group will receive routine care. Outcomes will be monitored at baseline, immediately after HSG and 15 min after HSG for each group. The primary outcome is the worst pain score during HSG by a visual analog scale (VAS). The secondary outcomes include: affective pain, cognitive pain, and anxiety during the HSG procedure; worst pain within 15 min after HSG; patient satisfaction and acceptance with pain management; physiological parameters; adverse effects; HSG results; and immersion perception score of the VR system (for the VR condition only). DISCUSSION: This study will focus on exploring a simply operated, noninvasive and low-cost analgesia during the HSG procedure. The results of this trial will provide data on the feasibility and safety of VR distraction therapy during HSG. TRIAL REGISTRATION: Chinese Clinical Trial Register, ChiCTR1900021342. Registered on 16 February 2019.


Assuntos
Analgesia/métodos , Histerossalpingografia/métodos , Dor Processual/terapia , Realidade Virtual , Adulto , Afeto , Ansiedade/psicologia , Feminino , Humanos , Histerossalpingografia/psicologia , Pessoa de Meia-Idade , Medição da Dor , Dor Processual/psicologia , Aceitação pelo Paciente de Cuidados de Saúde , Satisfação do Paciente , Resultado do Tratamento , Adulto Jovem
9.
Mikrochim Acta ; 186(12): 762, 2019 11 11.
Artigo em Inglês | MEDLINE | ID: mdl-31712906

RESUMO

The metal-organic frameworks MIL-101 and sulfo-MIL-101 were used to modify graphite paste electrodes (GPEs) to obtain sensors for determination of dopamine (DA). Taking advantage of the catalytic activity of metal-organic frameworks (MOFs) and of the electrical conductivity of graphite, the modified GPEs show enhanced voltammetric responses, and the GPE modified with the sulfo-MOF displays superior sensitivity when operated at a working potential of -0.4 to 0.8 V (vs. Ag/AgCl). The sensor works in the 0.07 to100 µM DA concentration range and has a 43 nM detection limit. It is concluded that the sulfo group provides open sites for efficient electrostatic and hydrogen bonding interactions, which facilitates electron transfer. Graphical abstractSchematic representation of the structure of the sulfo-functionalized MOF (sulfo-MIL-101) and the different voltammetric signals of dopamine at the graphite paste electrodes (GPEs) modified with sulfo-MIL-101 and the parent MOF (MIL-101).


Assuntos
Dopamina/análise , Técnicas Eletroquímicas/instrumentação , Grafite/química , Estruturas Metalorgânicas/química , Dopamina/química , Técnicas Eletroquímicas/métodos , Eletrodos , Limite de Detecção , Oxirredução
10.
ACS Appl Mater Interfaces ; 11(50): 47112-47120, 2019 Dec 18.
Artigo em Inglês | MEDLINE | ID: mdl-31738506

RESUMO

Sensitive fluorescence turn-on response to specific substances is highly desired for development of chemical sensors and switches. Here we utilized a "two-in-one" strategy to prepare ionic metal-organic frameworks (MOFs) functionalized with the cationic bipyridinium receptors at the frameworks and anionic fluorescent indicators in the pores. The MOFs are rendered a fluorescence-resting state because the indicator's fluorescence is efficiently quenched by the ground-state charge-transfer (CT) complexation between the indicator and receptor. Addition of an alkylamine efficiently turns on the fluorescence because the indicator is displaced by the CT complexation between alkylamine with receptor. The turn-on response is highly specific to alkylamines. The MOFs can be used as recyclable sensors for selective and sensitive detection of alkylamines, with ultralow detection limits (0.5 nM). The fluorescence in solid state can be reversibly switched on and off with high contrast. The sensitive and high-contrast response can be attributed to the space confinement effects of the porous frameworks. The confined space can significantly enhance indicator-receptor and analyte-receptor interactions, and thereby both the quenching efficiency in the off state and the displacement efficiency in the on state are amplified.

11.
J Emerg Med ; 57(4): 444-452, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31514988

RESUMO

BACKGROUND: Acute pain is the most common complaint in Emergency Department (ED) admissions, and options for analgesia are limited. Nitrous oxide/oxygen possesses many properties showing it may be an ideal analgesic in the ED. OBJECTIVES: The aim of this study is to evaluate the safety and analgesic effect of the fixed nitrous oxide/oxygen mixture for trauma patients in the ED. METHODS: We enrolled 60 patients in this double-blind, randomized study. The treatment group received conventional pain treatment plus a mixture of 65% nitrous oxide/oxygen. The control group received the conventional pain treatment plus oxygen. Primary outcome was the reduction in pain intensity at 5 and 15 min after the start of intervention. Secondary outcomes include adverse events, physiological parameters, and satisfaction from both patients and health care professionals. RESULTS: Initial pain scores for the nitrous oxide/oxygen group (6.0 [5.0-8.0]) and the oxygen group (6.75 [5.0-9.0]) were comparable (p = 0.57). The mean numerical rating scale scores at 5 min were 3.4 ± 1.8 and 7.0 ± 1.8 for nitrous oxide/oxygen and oxygen, respectively (p < 0.01). The mean pain intensity at 15 min in the treatment group was 3.0 ± 1.9, compared with 6.3 ± 2.2 in the control group (p < 0.01). Both patients' (8.0 [7.0-9.0] vs. 4.0 [2.0-6.0], p < 0.01) and physicians' (8.5 [8.0-9.0] vs. 4.0 [3.0-6.0], p < 0.01) satisfaction scores in the treatment group were significantly higher than the oxygen group. No serious adverse events were observed. CONCLUSIONS: This study gives supporting evidence for the safety and effectiveness of using self-administered nitrous oxide/oxygen mixture in the ED for moderate-to-severe traumatic pain.


Assuntos
Analgésicos/normas , Óxido Nitroso/farmacologia , Oxigênio/farmacologia , Manejo da Dor/normas , Ferimentos e Lesões/tratamento farmacológico , Dor Aguda/tratamento farmacológico , Adulto , Analgésicos/uso terapêutico , Método Duplo-Cego , Combinação de Medicamentos , Serviço Hospitalar de Emergência/organização & administração , Serviço Hospitalar de Emergência/estatística & dados numéricos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Óxido Nitroso/uso terapêutico , Oxigênio/uso terapêutico , Manejo da Dor/métodos , Manejo da Dor/estatística & dados numéricos , Medição da Dor/métodos , Satisfação do Paciente , Resultado do Tratamento , Ferimentos e Lesões/complicações
12.
Inorg Chem ; 58(20): 14167-14174, 2019 Oct 21.
Artigo em Inglês | MEDLINE | ID: mdl-31557004

RESUMO

A novel metal-organic framework (MOF), formulated as [Cd2(TTVTC)Cl2(H2O)3]·2H2O (1), was synthesized from a tetracarboxylate ligand ([TTVTC]2-) functionalized with the thiazolothiazole extended viologen (TTV2+) fluorophore. The MOF features three-dimensional (10,3)-d frameworks with 6-fold interpenetration. The MOF exhibits reversible photochromism, due to photoinduced electron transfer from carboxylate to TTV2+. The photoactivity benefits from the electron donor-acceptor contacts enabled by mutual interpenetration of the frameworks. This is the first demonstration of photochromism in TTV2+ derivatives. In addition, the fluorescence arising from the TTV2+ fluorophore can be reversibly modulated during the photochromic process. The work demonstrates the great potential of extended viologen based ligands in the construction of MOFs with dual photomodulable optical properties, which could find future applications in photoelectronics.

13.
Trials ; 20(1): 399, 2019 Jul 04.
Artigo em Inglês | MEDLINE | ID: mdl-31272502

RESUMO

BACKGROUND: The morbidity of knee arthritis is increasing among aged people and total knee arthroplasty has been its mainstream treatment to date. Postoperative rehabilitation is an important part of the procedure. However, the intense pain during the functional exercise involved has always been a challenge for both patients and health care professionals. The aim of this study is to test the analgesic effect of a mixture of nitrous oxide/oxygeb (1:1) inhalation for patients who are doing functional exercise 1 month after total knee arthroplasty. METHODS/DESIGN: This double-blind, randomized, placebo-controlled study will be implemented in the Rehabilitation Department in the General Hospital of Ningxia Medical University. Patients aged between 50 and 75 years who underwent a primary unilateral total knee arthroplasty are eligible for inclusion. The key exclusion criteria include: epilepsy, pulmonary embolism, intestinal obstruction, aerothorax. The treatment group (A) will receive a pre-prepared nitrous oxide/oxygen mixture plus conventional treatment (no analgesics), and the control group (B) will receive oxygen plus conventional treatment (no analgesics). Patients, physicians, therapists, and data collectors are all blind to the experiment. Assessments will be taken immediately after functional exercise begins (T0), 5 min (T1) after functional exercise begins, and 5 min after functional exercise has finished (T2). Patients will be randomly allocated between a treatment group (A) and a control group (B) in a ratio of 1:1. Primary outcome, including pain severity in the procedure, will be taken for each group. Secondary outcomes include blood pressure, heart rate, oxygen saturation, side effects, knee joint range of motion, Knee Society Score (KSS), rescue analgesia need, and satisfaction from both therapists and patients. DISCUSSION: This study will focus on exploring a fast and efficient analgesic for patients who are doing functional exercise after total knee arthroplasty. Our previous studies suggested that the prefixed nitrous oxide/oxygen mixture was an efficacious analgesic for the management of burn-dressing pain and breakthrough cancer pain. The results of this study should provide a more in-depth insight into the effects of this analgesic method. If this treatment proves successful, it could be implemented widely for patients doing functional exercise in the rehabilitation department. TRIAL REGISTRATION: ChiCTR-INR-17012891 . Registered on 6 October 2017.


Assuntos
Analgésicos não Narcóticos/administração & dosagem , Artralgia/prevenção & controle , Artrite/cirurgia , Artroplastia do Joelho/reabilitação , Terapia por Exercício , Articulação do Joelho/cirurgia , Óxido Nitroso/administração & dosagem , Oxigenoterapia , Dor Pós-Operatória/prevenção & controle , Idoso , Analgésicos não Narcóticos/efeitos adversos , Artralgia/diagnóstico , Artralgia/etiologia , Artralgia/fisiopatologia , Artrite/diagnóstico , Artrite/fisiopatologia , Artroplastia do Joelho/efeitos adversos , China , Método Duplo-Cego , Terapia por Exercício/efeitos adversos , Feminino , Humanos , Articulação do Joelho/fisiopatologia , Masculino , Pessoa de Meia-Idade , Óxido Nitroso/efeitos adversos , Oxigenoterapia/efeitos adversos , Medição da Dor , Dor Pós-Operatória/diagnóstico , Dor Pós-Operatória/etiologia , Dor Pós-Operatória/fisiopatologia , Ensaios Clínicos Controlados Aleatórios como Assunto , Fatores de Tempo , Resultado do Tratamento
14.
J Pain Symptom Manage ; 57(6): 1043-1050, 2019 06.
Artigo em Inglês | MEDLINE | ID: mdl-30853549

RESUMO

CONTEXT: Leukemia is the most common cancer in the childhood population. Lumbar puncture (LP) plays central role in the diagnosis and treatment process, but options for analgesia are limited. OBJECTIVES: The present study aims to evaluate the efficacy of a fixed N2O/O2 mixture to reduce pain in children with leukemia during LP as compared with placebo. METHODS: A double-blind, placebo-controlled, and randomized clinical trial involving children who needed LP for diagnosis or treatment was conducted in the pediatrics department of the General Hospital of Ningxia Medical University. Eligible patients were randomly assigned to inhale either a fixed N2O/O2 mixture or O2. The primary endpoint was the maximal pain level felt by the patient during the procedure measured using a numerical rating scale (0-10). RESULTS: One-hundred fourteen consecutive patients were enrolled in this study and randomized. Pain scores during the procedure showed a significant decrease in N2O/O2 mixture-treated patients to 1.05 ± 1.40 versus 8.00 ± 2.13 in controls (P < 0.01). No serious adverse effects were attributed to N2O/O2 mixture inhalation. Analysis of the satisfaction of patients receiving N2O/O2 mixture indicated that medical staff were satisfied with this treatment. CONCLUSIONS: This study demonstrated that self-administered fixed N2O/O2 is efficient to reduce pain related to LP in children with leukemia.


Assuntos
Analgésicos não Narcóticos/uso terapêutico , Leucemia/complicações , Óxido Nitroso/uso terapêutico , Oxigênio/uso terapêutico , Dor/tratamento farmacológico , Dor/etiologia , Punção Espinal/métodos , Administração por Inalação , Adolescente , Analgésicos não Narcóticos/efeitos adversos , Criança , Pré-Escolar , Método Duplo-Cego , Feminino , Humanos , Masculino , Óxido Nitroso/efeitos adversos , Oxigênio/efeitos adversos , Medição da Dor/efeitos dos fármacos , Satisfação do Paciente , Punção Espinal/efeitos adversos , Resultado do Tratamento
15.
Trials ; 19(1): 527, 2018 Sep 29.
Artigo em Inglês | MEDLINE | ID: mdl-30268163

RESUMO

BACKGROUND: Acute pain is always the most common complaint in Emergency Department admissions and options for analgesia are limited. Nitrous oxide/oxygen possess many properties showing it may be an ideal analgesic method for the Emergency Department; it is quick-acting, well-tolerated, and does not mask signs and symptoms. The aim of this study is to evaluate the safety and analgesic effect of the fixed nitrous oxide/oxygen mixture for trauma patients in a busy emergency environment. METHODS: The randomized, double-blind, prospective, placebo-controlled study will be carried out in the Emergency Department of General Hospital of Ningxia Medical University. The target research objects are trauma patients who present to the Emergency Department and report moderate to severe intensities of acute pain. A total of 90 patients will be recruited and randomly assigned into the treatment and control group. The treatment group will receive conventional pain treatment plus nitrous oxide/oxygen mixture and the control group will receive conventional pain treatment plus oxygen. Neither patients, nor investigators, nor data collectors will know the nature of the gas mixture in each cylinder and the randomization list. Outcomes will be monitored at baseline(T0), 5 min (T1), and 15 min (T2) after the beginning of intervention and at 5 min post intervention (T3) for each group. The primary outcome is the level of pain relief after the initial administering of the intervention at T1, T2, and T3. Secondary outcomes include adverse events, physiological parameters, total time of the gas administration, satisfaction from both patients and healthcare professionals, and the acceptance of patients. DISCUSSION: Our previous studies suggested that a fixed nitrous oxide/oxygen mixture was an efficacious analgesic for the management of burning dressing pain and breakthrough cancer pain. The results of this study will provide a more in-depth understanding of the effect of this gas. If this treatment proves successful, it could help to generate preliminary guidelines and be implemented widely in trauma patients with pain in Emergency Departments. TRIAL REGISTRATION: Chinese Clinical Trial Register, ChiCTR-INR-16007807 . Registered on 21 January 2016.


Assuntos
Dor Aguda/tratamento farmacológico , Analgésicos não Narcóticos/administração & dosagem , Serviços Médicos de Emergência , Óxido Nitroso/administração & dosagem , Oxigenoterapia , Ferimentos e Lesões/tratamento farmacológico , Dor Aguda/diagnóstico , Dor Aguda/fisiopatologia , Administração por Inalação , Analgésicos não Narcóticos/efeitos adversos , China , Método Duplo-Cego , Humanos , Óxido Nitroso/efeitos adversos , Medição da Dor , Satisfação do Paciente , Estudos Prospectivos , Ensaios Clínicos Controlados Aleatórios como Assunto , Fatores de Tempo , Resultado do Tratamento , Ferimentos e Lesões/diagnóstico , Ferimentos e Lesões/fisiopatologia
16.
Pain Manag Nurs ; 19(5): 506-515, 2018 10.
Artigo em Inglês | MEDLINE | ID: mdl-29506898

RESUMO

BACKGROUND: Breakthrough pain is an extremely painful symptom that impairs quality of life in cancer patients. It negatively impacts their emotional wellbeing, physical function, and mental health. The aim of this study is to use a qualitative methodology to examine the perception of cancer patients with breakthrough pain in the Northwest of China. METHODS: A semi-structured, face-to-face interview was conducted with nine cancer patients who experienced breakthrough pain; and a qualitative content analysis was performed. RESULTS: Five themes were generated: (1) sufferings from breakthrough cancer pain, (2) hopelessness and helplessness, (3) perception of breakthrough cancer pain and analgesia, (4) strong as a Chinese, and (5) support needed from health care system. CONCLUSION: Although certain traditional cultural worldviews increase patients' acceptance of pain, healthcare providers need proper treatment guidelines to improve the quality of cancer patient care in Northwest China. We recommend that healthcare workers and hospital managers place cancer pain management in higher priority. Relevant pain management education programs should be provided to both healthcare providers and patients to improve their knowledge in these area. Healthcare professionals need to establish a mutual communication channel between patients and healthcare workers to meet patients' needs during breakthrough pain episodes in order to improve pain management. Nevertheless, the government and the healthcare system need to recognize the importance and urgency of palliative care services.


Assuntos
Dor Irruptiva/complicações , Neoplasias/complicações , Adulto , Idoso , Dor Irruptiva/etiologia , Dor Irruptiva/psicologia , China , Feminino , Humanos , Entrevistas como Assunto/métodos , Masculino , Pessoa de Meia-Idade , Neoplasias/psicologia , Manejo da Dor/métodos , Manejo da Dor/normas , Cuidados Paliativos/psicologia , Pesquisa Qualitativa , Qualidade de Vida/psicologia
17.
BMJ Open ; 7(9): e015727, 2017 Sep 21.
Artigo em Inglês | MEDLINE | ID: mdl-28939570

RESUMO

OBJECTIVE: To obtain in-depth insight into the perceptions of parents and paediatricians in China regarding current procedural pain management on bone marrow aspirations and lumbar punctures in paediatric haemato-oncology department. DESIGN, SETTING AND PARTICIPANTS: This qualitative study was conducted in a 4500-bed university hospital in northwest China. To collect data, in-depth semistructured interviews were conducted with parents of children with acute leukaemia (n=12) and haemato-oncology paediatricians (n=11) using purposive sampling. Interviews were audiotaped and transcribed and subjected to thematic analysis. RESULTS: The suffering of procedural pain among paediatric patients was not adequately recognised and properly treated at the paediatric haemato-oncology department. The current paediatric procedural pain management is inadequate for paediatric patients. Crucial factors were identified including lack of awareness about the damage of uncontrolled pain in children, parents' low supportive ability, the limited capacity to provide general analgesia by anaesthetists, inadequate knowledge in the usage of analgesia and sedation and lack of efficient analgesic for children's procedural pain. The participants strongly expected optimal interventions to improve paediatric procedural pain management. CONCLUSIONS: The result suggested a perceived and actual poor management of paediatric procedural pain in haemato-oncology department in northwest China. A relevant pain management education programme for paediatricians and parents as well as an effective pain medication are urgently needed in northwest China. TRIAL REGISTRATION: Chinese Clinical Trial Registry. Identifier: ChiCTR-INR-16007989.


Assuntos
Exame de Medula Óssea/métodos , Manejo da Dor , Dor/etiologia , Pais/psicologia , Pediatras/psicologia , Punção Espinal/efeitos adversos , Doença Aguda , Analgésicos/uso terapêutico , Criança , Pré-Escolar , China , Feminino , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Entrevistas como Assunto , Leucemia/patologia , Masculino , Pesquisa Qualitativa
18.
Nan Fang Yi Ke Da Xue Xue Bao ; 31(4): 665-8, 2011 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-21515465

RESUMO

OBJECTIVE: To observe the inhibitory effect of resveratrol against the cytopathogenicity of enterovirus type 71. METHODS: The cytotoxicity of resveratrol on Vero cells was detected using cell counting kit-8 (CCK-8). The antiviral activity of resveratrol in different stages of infection, with ribavirin as the control, was evaluated by determining the virus inhibition rate, medium effective concentration (IC(50)), and selection index (SI). RESULTS: Resveratrol was nonpoisonous to Vero cells with an median toxic concentration (TC50) of 307.6 mmol/L. Resveratrol produced an obvious inhibitory effect against enterovirus type 71 only before the cell infection by the virus (IC(50)=20.2 mmol/L , SI=15.2), and once the cells were infected, resveratrol no longer had such antiviral effect. CONCLUSIONS: Resveratrol may offer some protection against enterovirus type 71 in vitro.


Assuntos
Antivirais/farmacologia , Medicamentos de Ervas Chinesas/farmacologia , Enterovirus/efeitos dos fármacos , Estilbenos/farmacologia , Animais , Chlorocebus aethiops , Resveratrol , Células Vero
19.
Nan Fang Yi Ke Da Xue Xue Bao ; 30(7): 1604-5, 1609, 2010 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-20650778

RESUMO

OBJECTIVE: To establish a model for predicting the density of Aedes albopictus based on the climate factors. METHODS: The data of Aedes albopictus density and climate changes from 1995 to 2001 in Guangzhou were collected and analyzed. The predicting model for Aedes albopictus density was established using the Artificial Neural Network Toolbox of Matlab 7.0 software package. The climate factors used to establish the model included the average monthly pressure, evaporation capacity, relative humidity, sunshine hour, temperature, wind speed, and precipitation, and the established model was tested and verified. RESULTS: The BP network model was established according to data of mosquito density and climate factors. After training the neural network for 25 times, the error of performance decreased from 0.305 539 to 2.937 51x10(-14). Verification of the model with the data of mosquito density showed a concordance rate of prediction of 80%. CONCLUSION: The neural network model based on the climate factors is effective for predicting Aedes albopictus density.


Assuntos
Aedes/fisiologia , Clima , Redes Neurais de Computação , Animais , Estações do Ano , Software
20.
Nan Fang Yi Ke Da Xue Xue Bao ; 30(6): 1333-5, 2010 Jun.
Artigo em Chinês | MEDLINE | ID: mdl-20584671

RESUMO

OBJECTIVE: To analyze the characteristics and etiology of hand, foot and mouth disease (HFMD) in a sentinel hospital of Guangzhou. METHODS: The epidemiological data and clinical specimens were collected from May to December, 2008 for virological investigations (viral isolation, RT-PCR and molecular identification) and phylogenetic analysis. RESULTS: A total of 309 clinical cases were reported, and the incidence was the highest in 2-4-year-old children, among whom only 15 developed complications, with human enterovirus 71 (HEV71) as the main pathogen (64.7%). Phylogenetic analysis indicated that ten Guangzhou EV71 isolates belonged to Cluster C4a. CONCLUSION: HFMD is an important infectious disease in children resulting from infections by HEV71 as the main pathogen in 2008, and the Guangzhou C4a strains co-evolved with the isolates from other provinces in China and the neighboring countries.


Assuntos
Enterovirus Humano A/isolamento & purificação , Doença de Mão, Pé e Boca/epidemiologia , Doença de Mão, Pé e Boca/virologia , Pré-Escolar , China/epidemiologia , Feminino , Humanos , Incidência , Masculino , Reação em Cadeia da Polimerase Via Transcriptase Reversa
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