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1.
Phys Ther ; 2020 Mar 11.
Artigo em Inglês | MEDLINE | ID: mdl-32157307

RESUMO

BACKGROUND: Virtual reality (VR) is a frequently used intervention for the rehabilitation of individuals with neurological disorders. PURPOSE: The aims of this review were to identify the short-term effect of VR on balance and to compare it with the effect of active interventions in individuals with Parkinson disease (PD). DATA SOURCES: Searches for relevant articles available in English were conducted using the MEDLINE (via PubMed), EMBASE, CENTRAL, CINAHL, PsycINFO, and Physiotherapy Evidence Database databases from inception until March 2019. STUDY SELECTION: All randomized controlled trials comparing the effect of training with VR and the effect of training without VR on balance in individuals with PD were included. DATA EXTRACTION: Two authors independently extracted data, assessed the methodological quality, and evaluated the evidence quality of the studies. DATA SYNTHESIS: Fourteen randomized controlled trials including 574 individuals were eligible for qualitative analyses, and 12 of the studies involving 481 individuals were identified as being eligible for meta-analyses. Compared with active interventions, the use of VR improved the Berg Balance Scale score mean difference = 1.23; 95% CI = 0.15 to 2.31; I2 = 56%). The Dynamic Gait Index and Functional Gait Assessment results were also significant after the sensitivity analyses (mean difference = 0.69; 95% CI = 0.12 to 1.26; I2 = 0%). Both provided moderate statistical evidence. (However, the Timed "Up & Go" Test and the Activities-Specific Balance Confidence Scale did not differ significantly. LIMITATIONS: Publication bias and diversity in the interventions were the main limitations. CONCLUSIONS: Existing moderate evidence of the effectiveness of VR with the Berg Balance Scale, Dynamic Gait Index, and Functional Gait Assessment for individuals with PD was promising. Although the differences did not reach the clinically important change threshold, VR was comparable to the active interventions and could be considered an adjuvant therapy for balance rehabilitation in individuals with PD.

2.
Nano Lett ; 2020 Mar 11.
Artigo em Inglês | MEDLINE | ID: mdl-32142296

RESUMO

Polaritons in two-dimensional (2D) materials have shown their unique capabilities to concentrate light into deep subwavelength scales. Precise control of the excitation and propagation of 2D polaritons has remained a central challenge for future on-chip nanophotonic devices and circuits. To solve this issue, we exploit Cherenkov radiation, a classic physical phenomenon that occurs when a charged particle moves at a velocity greater than the phase velocity of light in that medium, in low-dimensional material heterostructures. Here, we report an experimental observation of Cherenkov phonon polariton wakes emitted by superluminal one-dimensional plasmon polaritons in a silver nanowire and hexagonal boron nitride heterostructure using near-field infrared nanoscopy. The observed Cherenkov radiation direction and radiation rate exhibit large tunability through varying the excitation frequency. Such tunable Cherenkov phonon polaritons provide opportunities for novel deep subwavelength-scale manipulation of light and nanoscale control of energy flow in low-dimensional material heterostructures.

3.
Environ Technol ; : 1-9, 2020 Mar 16.
Artigo em Inglês | MEDLINE | ID: mdl-32149576

RESUMO

ABSTRACTAgrobacterium sp. LAD9 capable of heterotrophic-aerobic nitrogen removal was applied into a single biological aerated filter (BAF) for bioaugmented treatment of municipal wastewater. The achievement of simultaneous nitrogen and carbon removal in the bioaugmented system was systematically evaluated by ratios of COD to nitrogen (COD/N), ranging from 1 to 20. The results showed that at an appropriate COD/N ratio of 10, the BAF exhibited excellent carbon and nutrients removal, the averaged removal efficiencies for COD, NH4+-N and TN were 92.3%, 100% and 80.0%, respectively. Long-term operation of the bioaugmented system also confirmed the stability of the treatment efficiency. Further comparisons of SOUR and PCR-DGGE profiles between the bioaugmented and the control system revealed that the introduction of strain LAD9 greatly changed the structure of original microbial community and facilitated their capabilities of aerobic nutrients removal. The proposed bioaugmentation strategy is of particular importance to upgrading or retrofitting concurrent municipal wastewater treatment systems.

4.
Elife ; 92020 Mar 24.
Artigo em Inglês | MEDLINE | ID: mdl-32207684

RESUMO

Carbon catabolite repression 4 (CCR4) is a conserved mRNA deadenylase regulating posttranscriptional gene expression. However, regulation of CCR4 in virus infections is less understood. Here, we characterized a pro-viral role of CCR4 in replication of a plant cytorhabdovirus, Barley yellow striate mosaic virus (BYSMV). The barley (Hordeum vulgare) CCR4 protein (HvCCR4) was identified to interact with the BYSMV phosphoprotein (P). The BYSMV P protein recruited HvCCR4 from processing bodies (PBs) into viroplasm-like bodies. Overexpression of HvCCR4 promoted BYSMV replication in plants. Conversely, knockdown of the small brown planthopper CCR4 inhibited viral accumulation in the insect vector. Biochemistry experiments revealed that HvCCR4 was recruited into N-RNA complexes by the BYSMV P protein and triggered turnover of N-bound cellular mRNAs, thereby releasing RNA-free N protein to bind viral genomic RNA for optimal viral replication. Our results demonstrate that the co-opted the CCR4-mediated RNA decay facilitates cytorhabdovirus replication in plants and insects.

5.
Artigo em Inglês | MEDLINE | ID: mdl-32125146

RESUMO

Flexible strain or pressure sensors have potential applications in electronic skin, healthcare, etc. It remains a challenge to explore multifunctional strain or pressure sensors that possess excellent water repellent and heating performance and hence can be used in harsh environments such as high moisture and low-temperature conditions. Here, a self-derived superhydrophobic and multifunctional polymer composite foam is prepared by adsorption of the Ag precursor in tetrahydrofuran (THF) onto the rubber sponge followed by reduction of Ag+ to Ag nanoparticles (AgNPs). During the Ag+ reduction in hydrazine solution, the swollen rubber sponge by THF is partially precipitated based on the nonsolvent-induced phase separation (NIPS). The NIPS creates a porous structure on the sponge surface and thus a high surface roughness, contributing to the material superhydrophobicity. The precipitated polymer wrapping the AgNPs could enhance the interaction between the individual AgNPs. The obtained conductive sponge composite possesses excellent Joule heating and photothermal performance and can be used as both a strain and pressure sensor. The conductive sponge composite sensor possesses good reliability and durability and can be applied to real-time monitoring of human body movements.

6.
J Ovarian Res ; 13(1): 12, 2020 Feb 03.
Artigo em Inglês | MEDLINE | ID: mdl-32014030

RESUMO

BACKGROUND: Degeneration of ovarian function is an obvious feature of female aging. In addition, studies have shown that autophagy decreases with age, and DNA methylation is a hallmark epigenetic pattern during aging. However, it is not clear whether the expression and DNA methylation of autophagy genes are involved in the declines in ovarian function that occur during aging. RESULTS: Three groups of rats were used: 6-month-old (6 M) rats, 12-month-old (12 M) rats and 24-month-old (24 M) rats. Serum E2 levels and the mRNA and protein expression levels of Atg5, Atg12, Atg16L, Beclin1 and Lc3B were significantly decreased in aged rats. In addition, the methylation levels of the Atg5 gene were significantly increased in aged rats. The expression of the Dnmt1 and Dnmt2 genes decreased with aging; however, the expression of the Dnmt3A and Dnmt3B genes gradually increased with aging. CONCLUSIONS: Decreased autophagic activity was involved in the declines in ovarian function in aging rats. Upregulation of the DNA methyltransferases Dnmt3A and Dnmt3B may have led to methylation of the autophagy genes Atg5 and Lc3B to ultimately cause the observed decreases in autophagic activity.

7.
Sensors (Basel) ; 20(3)2020 Feb 04.
Artigo em Inglês | MEDLINE | ID: mdl-32033014

RESUMO

Wireless sensor network (WSN) nodes are devices with limited power, and rational utilization of node energy and prolonging the network lifetime are the main objectives of the WSN's routing protocol. However, irrational considerations of heterogeneity of node energy will lead to an energy imbalance between nodes in heterogeneous WSNs (HWSNs). Therefore, in this paper, a routing protocol for HWSNs based on the modified grey wolf optimizer (HMGWO) is proposed. First, the protocol selects the appropriate initial clusters by defining different fitness functions for heterogeneous energy nodes; the nodes' fitness values are then calculated and treated as initial weights in the GWO. At the same time, the weights are dynamically updated according to the distance between the wolves and their prey and coefficient vectors to improve the GWO's optimization ability and ensure the selection of the optimal cluster heads (CHs). The experimental results indicate that the network lifecycle of the HMGWO protocol improves by 55.7%, 31.9%, 46.3%, and 27.0%, respectively, compared with the stable election protocol (SEP), distributed energy-efficient clustering algorithm (DEEC), modified SEP (M-SEP), and fitness-value-based improved GWO (FIGWO) protocols. In terms of the power consumption and network throughput, the HMGWO is also superior to other protocols.

8.
J Colloid Interface Sci ; 566: 401-410, 2020 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-32018180

RESUMO

Exploiting water-based fabric coatings outfitted with multiple protections (e.g., waterproofness, ultraviolet (UV) resistance and thermal insulation) are urgently demanded. Nevertheless, achieving the multifunction and durability poses the major challenge. In the present study, novel multifunctional cellulose/silica hybrid microcapsules were developed by one-step emulsion-solvent diffusion; these microcapsules were well dispersed into waterborne silicone resins to form waterborne multiple protective fabric coatings. Since the encapsulated phase change materials were in the core of capsules, and the hydrophobic coupling reagent and UV absorber were grafted onto the silicas in the shell of capsules, these fabric coatings exhibited high superhydrophobicity, UV protection and thermal insulation. Moreover, because hydrophobic coupling reagent and UV absorber in the shell-cellulose of capsules exhibited easy mobility, the fabric coatings displayed self-repairability of superhydrophobicity and UV protection even after being damaged chemically or mechanically. The fabric coating presented in this study could have a range of applications, covering special protective fabric, high-altitude garments as well as self-cleaning materials.

9.
Cancer Lett ; 476: 67-74, 2020 Apr 28.
Artigo em Inglês | MEDLINE | ID: mdl-32061752

RESUMO

Drug resistance is a big problem in cancer treatment and one of the most prominent mechanisms underlain is overexpression of ATP-binding cassette (ABC) transporters, particularly ABCB1, ABCC1 and ABCG2. Inhibition of ABC transporters is an important approach to overcome drug resistance. The inositol-requiring enzyme 1α (IRE1α), an arm of unfolded protein response (UPR), splices XBP1 mRNA to generate an active transcription factor XBP1s. UPR is implicated in drug resistance. However, the underlying mechanism is unclear. We found that the anticancer drugs such as 5-fluorouracil (5-FU) activated the IRE1α-XBP1 pathway to induce the expression of ABCB1, ABCC1 and ABCG2 in colon cancer cells. Inhibition of IRE1α RNase activity with small molecule 4µ8c suppressed the drug-induced expression of these ABC transporters and sensitized 5-FU-resistant colon cancer cells to drug treatment. In vivo xenograft assay indicates that administration of 4µ8C substantially enhanced the efficacy of 5-FU chemotherapy on 5-FU-resistant colon cancer cells. These results suggest that IRE1α-targeting might be a strategy to cope with drug resistance of colon cancer.

10.
Nanoscale ; 2020 Feb 28.
Artigo em Inglês | MEDLINE | ID: mdl-32108839

RESUMO

Based on density functional theory calculations, we investigated two-dimensional in-plane ordered MXenes (i-MXenes), focusing particularly on their magnetic properties. It has been observed that robust two-dimensional magnetism can be achieved by alloying nonmagnetic MXenes with magnetic transition metal atoms. Moreover, both the magnetic ground states and the magnetocrystalline anisotropy energy of i-MXenes can be effectively manipulated by strain, indicating a strong piezomagnetic effect. Further studies on the transport properties reveal that i-MXenes provide an interesting platform to realize large thermoelectric response, antiferromagnetic topological insulators, and spin-gapless semiconductors. Thus, i-MXenes are a new class of multifunctional two-dimensional magnetic materials which are promising for future spintronic applications.

11.
Carbohydr Polym ; 232: 115821, 2020 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-31952616

RESUMO

The synthesis of multifunctional microcapsules using natural polymers has contributed to a broad range of practical applications on fabric coatings. This paper presents a facile and environment-friendly approach for waterborne multifunctional fabric coatings by using cellulose/silica hybrid microcapsules. In this method, lavender fragrance oil-loaded cellulose/silica hybrid microcapsules were one-step synthesized via emulsion solvent diffusion. This microcapsule is core-shell structure with UV absorbers and methacrylic acid grafted silica in the shell and then added into the waterborne polysiloxane resins to form multifunctional fabric coatings. The as-obtained fabric coatings not only exhibited controlled lavender fragrance oil-releasing performance, and it can keep above 30 % fragrance after ninety days due to the slow releasing of lavender fragrance oil in the capsules, but also showed excellent UV resistant property with 159 UPF value.

12.
Cell Death Differ ; 2020 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-31959916

RESUMO

Intestinal epithelia self-renew constantly and generate differentiated cells such as secretary goblet cells. The intestine goblet cells secrete gel-forming mucins that form mucus to create a barrier of defense. We reported previously that loss of prolyl hydroxylase (PHD) 3 led to disruption of the intestinal epithelial barrier function. However, the underlying mechanism remains elusive. Here, we demonstrate that PHD3 controls the generation of intestine goblet cell. We found that genetic ablation of Phd3 in mice intestine epithelial cells reduced the amount of goblet cells. Mechanistically, PHD3 bounds the E3 ubiquitin ligase HUWE1 and prevented HUWE1 from mediating ubiquitination and degradation of ATOH1, an essential driver for goblet cell differentiation. The prolyl hydroxylase activity-deficient variant PHD3(H196A) also prevented ATOH1 destruction. A genetic intestine epithelial PHD3(H196A)-knockin had no effect on ATOH1 expression or goblet cell amount in mice, suggesting that the PHD3 prolyl hydroxylase activity is dispensable for its ability to control ATOH1 expression and goblet cell generation. In dextran sulfate sodium (DSS)-induced experimental colitis, PHD3-knockout rather than PHD3(H196A)-knockin sensitized the mice to DSS treatment. Our results reveal an additional critical mechanism underlying the regulation of ATOH1 expression and goblet cell generation and highlight that PHD3 plays a role in controlling intestine goblet cell generation in a hydroxylase-independent manner.

13.
J Med Chem ; 63(3): 1233-1244, 2020 Feb 13.
Artigo em Inglês | MEDLINE | ID: mdl-31939669

RESUMO

Human hand, foot, and mouth disease (HFMD) is a serious public health threat with high infection rates in children and infants who reside in Asia and the Pacific regions, and no effective drugs are currently available. Enterovirus 71 (EV71) and coxsackievirus A16 are the major etiological pathogens. Based on an essential hydrophobic pocket on the viral capsid protein VP1, we designed and synthesized a series of small molecular weight compounds as inhibitors of EV71. A potential drug candidate named NLD-22 exhibited excellent antiviral activity (with an EC50 of 5.056 nM and a 100% protection rate for mice at a dose of 20 mg/kg) and low toxicity. NLD-22 had a favorable pharmacokinetic profile. High-resolution cryo-electron microscopy structural analysis confirmed NLD-22 bound to the hydrophobic pocket in VP1 to block viral infection. In general, NLD-22 was indicated to be a promising potential drug candidate for the treatment of HFMD.

14.
Bioinformatics ; 2020 Jan 30.
Artigo em Inglês | MEDLINE | ID: mdl-31999326

RESUMO

MOTIVATION: One of the most important problems in drug discovery research is to precisely predict a new indication for an existing drug, i.e. drug repositioning. Recent recommendation system-based methods have tackled this problem using matrix completion models. The models identify latent factors contributing to known drug-disease associations, and then infer novel drug-disease associations by the correlations between latent factors. However, these models have not fully considered the various drug data sources and the sparsity of the drug-disease association matrix. In addition, using the global structure of the drug-disease association data may introduce noise, and consequently limit the prediction power. RESULTS: In this work, we propose a novel drug repositioning approach by using Bayesian inductive matrix completion (DRIMC). Firstly, we embed four drug data sources into a drug similarity matrix and two disease data sources in a disease similarity matrix. Then, for each drug or disease, its feature is described by similarity values between it and its nearest neighbors, and these features for drugs and diseases are mapped onto a shared latent space. We model the association probability for each drug-disease pair by inductive matrix completion, where the properties of drugs and diseases are represented by projections of drugs and diseases, respectively. As the known drug-disease associations have been manually verified, they are more trustworthy and important than the unknown pairs. We assign higher confidence levels to known association pairs compared with unknown pairs. We perform comprehensive experiments on three benchmark datasets, and DRIMC improves prediction accuracy compared with six stat-of-the-art approaches. AVAILABILITY AND IMPLEMENTATION: Source code and datasets are available at https://github.com/linwang1982/DRIMC. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

15.
Med Sci Monit ; 26: e919601, 2020 Jan 30.
Artigo em Inglês | MEDLINE | ID: mdl-31997826

RESUMO

BACKGROUND Ischemia-reperfusion injury (IRI) results from the restoration of blood supply to ischemic organs, including the heart. Expression of microRNA-668-3p (miR-668-3p) is known to protect the kidney from IRI. This study aimed to investigate the role of miR-668-3p in oxygen-glucose deprivation (OGD) in a rat H9c2 cardiomyocyte model of IRI. MATERIAL AND METHODS Rat H9c2 cardiomyocytes were cultured in glucose-free Dulbecco's modified Eagle's medium (DMEM) under anaerobic conditions, followed by oxygenation, to create the OGD model of IRI. The luciferase reporter assay evaluated the interaction between stromal cell-derived factor-1 (SDF-1), or CXC motif chemokine 12 (CXCL12), and miR-668-3p. Protein and mRNA levels of SDF-1, CXCR4, Bcl2, Bax, cleaved caspase-3, endothelial nitric oxide synthase (eNOS), and phosphorylated endothelial nitric oxide synthase (p-eNOS) were analyzed by Western blot and quantitative reverse transcription-polymerase chain reaction (RT-qPCR), and apoptosis were assessed by flow cytometry. Enzyme-linked immunosorbent assay (ELISA) measured reactive oxygen species (ROS), including malondialdehyde (MDA), nitric oxide (NO), p-eNOS, and the inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha), interleukin-1ß (IL-1ß), IL-6, and monocyte chemoattractant protein-1 (MCP-1) in H9c2 cell supernatants. RESULTS In the OGD rat H9c2 cardiomyocyte model of IRI, miR-668-3p levels were reduced. Overexpression of miR-668-3p inhibited SDF-1, CXCR4, the expression of inflammatory cytokines, markers of oxidative stress, and p-eNOS. The overexpression of SDF-1 reversed these findings. Overexpression of SDF-1 promoted cell apoptosis, which was reduced by miR-668-3p. CONCLUSIONS In the OGD rat H9c2 cardiomyocyte model of IRI, miR-668-3p suppressed mediators of inflammation and oxidative stress and enhanced cell viability through the SDF-1/CXCR4 signaling pathway.

16.
Cancer Biomark ; 27(2): 265-275, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31929144

RESUMO

BACKGROUND: Tumor-infiltrating immune cells are indispensable to the progression and prognosis of clear cell renal cell carcinoma (ccRCC). OBJECTIVE: The aim of this study was to explore the clinical implications of immune cell infiltrates in ccRCC. METHODS: The Cancer Genome Atlas (TCGA) database (N= 515) and E-MTAB-1980 cohort of patients (N= 101) were adopted to estimate the prognostic value of immune cell infiltration. Twenty-four types of immune cells were evaluated using single-sample gene set enrichment analysis. Cox regression analyses were conducted to develop an immune risk score. RESULTS: Survival analyses revealed that 13 genes significantly associated with the overall survival (OS). Furthermore, multivariate Cox analysis identified an immune risk score on the basis of mast cells, natural killer CD56bright cells, T helper 17 (Th17) cells, and Th2 cells. The immune risk score was associated with OS, with hazard ratios of 2.72 (95% CI 2.17-3.40) and 3.24 (95% CI 1.64-6.44) in TCGA and E-MTAB-1980 datasets, respectively. This immune risk score was significantly correlated with some immunotherapy-related biomarkers. CONCLUSIONS: We profiled a prognostic signature and established an immune risk score model for ccRCC, which could provide novel predictive markers for patients with ccRCC and an indicator for immunotherapy response measurement.

17.
FASEB J ; 34(1): 1872-1884, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31914700

RESUMO

Intracerebral hemorrhage (ICH) remains a devastating type of stroke that lacks an effective treatment. Recent evidence has demonstrated that CCL2 is involved in the blood-brain barrier (BBB) disruption and propagermanium (PG) as a CCL2 receptor inhibitor is neuroprotective in ischemic stroke. However, whether PG therapy exert effective role in acute ICH still unclear. In this study, our goal was to investigate the potential role of CCL2 and the effects of PG in ICH. Differentially expressed RNAs including CCL2 were detected in human ICH. CCL2 and the activation of p-p38 MAPK and AQP4 expression were analyzed in rats after ICH. Brain water content and BBB integrity as well as neurological function were also examined after PG administration. In addition, the mechanism by which CCL2-mediated BBB injury was further investigated by cell coculture. Our findings showed that PG could effectively reduce brain edema and improve neurobehavioral functions. p-p38 MAPK and AQP4 expression were significantly inhibited by PG in vivo and in vitro. To the best of our knowledge, this is the first demonstration of PG in neuroprotecting the BBB integrity by inhibition of CCL2-CCR2-p38 MAPK pathway following ICH, targeting CCL2 could be developed as a novel treatment for hemorrhagic stroke.

18.
Cell Death Dis ; 11(1): 37, 2020 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-31959747

RESUMO

As the foundation of male fertility, spermatogenesis is a complicated and highly controlled process. YTHDF2 plays regulatory roles in biological processes through accelerating the degradation of target mRNAs. However, the function of YTHDF2 in spermatogenesis remains elusive. Here, we knocked out Ythdf2 in mouse spermatogonia via CRISPR/Cas9, and found that depletion of Ythdf2 mainly downregulated the expression of matrix metallopeptidase (MMPs), thus affecting cell adhesion and proliferation. m6A-IP-PCR and RIP-PCR analysis showed that Mmp3, Mmp13, Adamts1 and Adamts9 were modified with m6A and simultaneously interacted with YTHDF2. Moreover, inhibition of Mmp13 partially rescued the phenotypes in Ythdf2-KO cells. Taken together, YTHDF2 regulates cell-matrix adhesion and proliferation through modulating the expression of Mmps by the m6A/mRNA degradation pathway.

19.
J Mater Chem B ; 2020 Jan 03.
Artigo em Inglês | MEDLINE | ID: mdl-31897454

RESUMO

The electrochemiluminescence (ECL) method has attracted increasing attention in analytical fields. However, ECL luminophores with high ECL efficiency both at positive and negative potentials still remain rare. Herein, we synthesized ruthenium complex-functionalized CdS quantum dots (QDs) with high ECL efficiency both at positive and negative potentials in aqueous solution. CdS QDs were chosen as the ECL donor while bis(2,2'-bipyridine)-(5-aminophenanthroline)ruthenium bis(hexafluorophosphate) (Ru-NH2) was employed as the ECL acceptor. Ru-NH2 was covalently coupled to the surface of CdS QDs via diazonium salt chemistry to form CdS-Ru nanoparticles. ECL resonance energy transfer (ECL-RET) occurred inside the CdS-Ru nanoparticles and strong ECL emissions were obtained from CdS-Ru nanoparticles at both positive potential in the presence of tri-n-propylamine and at negative potential in the presence of peroxydisulfate. Further, the combination of the excellent recognition ability of the aptamer and the good ECL behavior of CdS-Ru nanoparticles, as a proof-of-concept, showed that two sensitive ECL methods for the detection of thrombin were readily achieved under different ECL measurement conditions with a low detection limit of 0.6 pM and 0.7 pM. This work demonstrates that CdS-Ru nanoparticles with intramolecular ECL-RET are good ECL luminophores in the sensitive detection of targets, which is promising in multiple assays with spectrum-resolved and potential-resolved possibility for biological applications.

20.
Small ; : e1907172, 2020 Jan 22.
Artigo em Inglês | MEDLINE | ID: mdl-31967725

RESUMO

Structural symmetry is a simple way to quantify the anisotropic properties of materials toward unique device applications including anisotropic transportation and polarization-sensitive photodetection. The enhancement of anisotropy can be achieved by artificial symmetry-reduction design. A core-shell SbI3 /Sb2 O3 nanowire, a heterostructure bonded by van der Waals forces, is introduced as an example of enhancing the performance of polarization-sensitive photodetectors via symmetry reduction. The structural, vibrational, and optical anisotropies of such core-shell nanostructures are systematically investigated. It is found that the anisotropic absorbance of a core-shell nanowire is obviously higher than that of two single compounds from both theoretical and experimental investigations. Anisotropic photocurrents of the polarization-sensitive photodetectors based on these core-shell SbI3 /Sb2 O3 van der Waals nanowires are measured ranging from ultraviolet (UV) to visible light (360-532 nm). Compared with other van der Waals 1D materials, low anisotropy ratio (Imax /Imin ) is measured based on SbI3 but a device based on this core-shell nanowire possesses a relatively high anisotropy ratio of ≈3.14 under 450 nm polarized light. This work shows that the low-symmetrical core-shell van der Waals heterostructure has large potential to be applied in wide range polarization-sensitive photodetectors.

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