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1.
Comput Intell Neurosci ; 2022: 7620287, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36052043

RESUMO

Moyamoya disease is a medical condition that shows the typical characteristics like continuous and chronic thickening of the walls and the contraction of the internal carotid artery; as a result, the internal diameter of the artery gets narrowed. There are six phases of the disease ranging from I to VI (moyamoya vessels completely disappear, followed by the complete blockage of the arteries). Surgery is a commonly recommended treatment for the moyamoya disease. Our research study identifies the effect of autologous bone marrow stem cell therapy (ABMSCT) on the levels of inflammatory factors and Conexin43 (Cx43) protein in patients suffering from moyamoya. In our study, we have selected 52 moyamoya patients admitted to our hospital from 30 July 2019 to 10 February 2020. The control group (CG) was treated with superficial temporal artery to a middle cerebral artery (STA-MCA) bypass + encephalo-duro-myosinangiosis (EDMS). The experimental group (Exp. Grp) was treated with ABMSC. The cerebral vascular tissue of the patients was treated with hematoxylin-eosin (HE) staining. Immunohistochemical staining was used to identify the levels of Cx43 protein. The concentrations of vascular endothelial growth factor (VEGF), inflammatory factor interleukin-6 (IL6), interleukin-1ß (IL1ß), tumor necrosis factor (TNFα), and anti-inflammatory factor interleukin-1ß (IL1ß) were determined by enzyme-linked immunosorbent assay (ELISA). We have found that after treatment of the expression of Cx43 protein, the proportions of grade IV (7.7%), grade III (311.5%), and grade II (3.8%) patients in the Exp. Grp were lower than those in the CG. The proportion of grade I patients in the Exp. Grp (77%) was higher than that in the CG (38.5%). After treatment, the inflammatory factors IL6 (0.97 ± 0.82 pg/mL), IL1ß (8.33 ± 1.21 pg/mL), and TNFα (1.73 ± 0.71 pg/mL) in the Exp. Grp were lower than those in the CG. The anti-inflammatory factor IL1ß (15.09 ± 4.72 pg/mL) increased in the Exp. Grp compared with the CG (11.25 ± 3.48 pg/mL) post treatment. Intracranial infection, hydrocephalus, hemiplegia, and transient neurological dysfunction in the Exp. Grp were lower than those in the CG, with statistical differences (P < 0.05). Our study suggests that the treatment of autologous bone marrow stem cells (ABMSC) was beneficial to balance the inflammatory response of disorders, reduce the damage of vascular tissue in the brain, and regulate tissue repair by co-acting with various inflammatory factors as compared to traditional surgery. We conclude that the involvement of Cx43 in the occurrence and development of moyamoya. We also have found that the risk factors of intracranial infection after ABMSCT were less as compared to those after conventional surgery.


Assuntos
Revascularização Cerebral , Doença de Moyamoya , Medula Óssea/patologia , Medula Óssea/cirurgia , Células da Medula Óssea/patologia , Conexina 43 , Humanos , Interleucina-1beta , Interleucina-6 , Doença de Moyamoya/patologia , Doença de Moyamoya/terapia , Fator de Necrose Tumoral alfa , Fator A de Crescimento do Endotélio Vascular
2.
Phys Chem Chem Phys ; 24(36): 21666-21673, 2022 Sep 21.
Artigo em Inglês | MEDLINE | ID: mdl-36069358

RESUMO

Metal chalcogenides have become popular materials for next-generation electronic devices due to their wide band gap and excellent transport properties. Specifically, two-dimensional metal chalcogenides also have outstanding physical properties. For electronic devices, the carrier mobility is a key parameter because it affects the material conductivity and the response time. As a member of metal chalcogenides, GaS has attracted the attention of scholars. In this work, by using first principles calculations and the Wannier function interpolation, the electronic and phonon properties, the electron-phonon interaction, the scattering rate, and the carrier mobility of monolayer and bulk GaS are systematically studied. The results show that GaS is a semiconductor and both monolayer and bulk GaS are dynamically stable. The LO phonon modes at long wavelengths strongly affect the carrier migration in GaS. We give the carrier mobility of monolayer and bulk GaS as a function of temperature (100 < K < 500). In addition, we compare the carrier mobility of GaS with several other metal chalcogenides (monolayer and bulk InSe, monolayer GeS, and monolayer GeSe) at 300 K. The results show that an increase in temperature leads to a decrease in the carrier mobility and the electron (hole) mobility of monolayer and bulk GaS is 10.85 cm2 V-1 s-1 (0.22 cm2 V-1 s-1) and 1229.79 cm2 V-1 s-1 (9.28 cm2 V-1 s-1), respectively. By comparing with the carrier mobility of other chalcogenides, we can find that the electron mobility of bulk GaS is the highest, which indicates that bulk GaS has high application potential.

3.
Chem Asian J ; : e202200587, 2022 Aug 22.
Artigo em Inglês | MEDLINE | ID: mdl-35994590

RESUMO

Non-aqueous redox flow batteries (RFBs) are emerging electrochemical technologies for grid energy storage. Non-aqueous Mg RFBs that use Mg metal as the anode are especially promising due to various benefits of the Mg metal anode, including its low potential, high volumetric capacity, SEI-free, highly reversible operation and low cost. Despite the potential, there are rarely any studies on developing non-aqueous Mg RFBs. Herein, a non-aqueous Mg redox flow battery using a polymer catholyte is reported. Through rational molecular engineering, a carbonyl-based moiety is combined with a polyethylene glycol moiety to achieve a polymer with high voltage and high solubility in the ether-based electrolyte. A series of polymers with different polyethylene glycol chain lengths are synthesized and their performances are measured first at the molecular level, and then at the device level in a Mg redox flow battery using a Mg foil as the anode, the polymer solution as the catholyte and a porous membrane as the separator. The flow battery delivers a voltage of 1.8 V, a maximum capacity of 475 mAh/L, an average Coulombic efficiency of 90.5%, an average voltage efficiency of 67.4%, an energy efficiency of 61.0%, and an energy density of 0.855 Wh/L. Systematic mechanistic studies are performed to understand the performance decay mechanism and possible strategies for future improvement are discussed. This work opens a new avenue for the development of energy storage technologies for grid electricity storage.

4.
Spectrochim Acta A Mol Biomol Spectrosc ; 282: 121679, 2022 Dec 05.
Artigo em Inglês | MEDLINE | ID: mdl-35917619

RESUMO

We theoretically investigate the possibility of laser cooling 87Sr35Cl molecule in accordance with vibrational and hyperfine spectroscopy. The potential energy curves and dipole moment of the X2Σ+1/2, A2Π1/2,3/2 and B2Σ+ states are calculated using ab initio method and the spectroscopic parameters are in good agreement with the experimental data. On account of the accurate potential energy curves and the transition dipole moment, the Franck - Condon factors and radiative lifetimes are predicted. Comparing the conditions of laser cooling candidate molecules, the A2Π 1/2 â†” X2Σ+1/2 transition is selected as the laser cooling cycle system. In order to obtain an approximately closed cooling cycle system, we employed matrix element algorithm to calculated the hyperfine spectroscopy and branching ratios of the 87Sr35Cl molecule. Furthermore, an electro-optical modulator (EOM) is designed including six hyperfine levels of the ground state X2Σ+1/2 (v = 0, N = 1).

5.
Chemosphere ; 307(Pt 2): 135885, 2022 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-35926747

RESUMO

Manganese oxide (especially manganese dioxide [MnO2]) is an excellent catalytic material for SO2 removal in flue gas desulfurization. In this study, the effect of crystalline structure of MnO2 (α-MnO2, ß-MnO2, γ-MnO2 and δ-MnO2) on their activity for SO2 oxidation was studied based on density functional theory with Hubbard U corrections (DFT + U). The calculated results showed that α-MnO2 has mild energy barriers of 0.69 eV and 0.46 eV, and ß-MnO2 has poor redox performance on SO2 molecules, which has the highest energy barrier of 2.17 eV and the largest oxygen formation energy of 1.74 eV, making it difficult for the oxygen atom to remove from the surface lattice to form reactive sites. Thermodynamic calculations showed that α-MnO2 is suitable for SO2 oxidation for its low energy barriers, reaction energy close to zero in the first half, and relatively high spontaneity in the whole reaction. Experimental tests showed that α-MnO2 had the best catalytic oxidation effect, with the highest sulfur capacity (304.11 mg/g), but ß-MnO2 had poor catalytic oxidation performance, with a sulfur capacity of 41.59 mg/g. This work studies the catalytic performance and mechanism of SO2 removal and proposes a strategy to improve the catalytic activity by phase structure.

6.
Artigo em Inglês | MEDLINE | ID: mdl-35822941

RESUMO

To enable the mass adoption of electric vehicles, the charging performance of Li-ion batteries needs to be significantly enhanced. The development of electrolytes with enhanced transport properties and faster interfacial reaction is one critical approach to realize fast charging within 10 min. Most current electrolyte studies are focusing on ester-based electrolytes. In this work, an ether-based electrolyte is reported, which shows remarkably better charging performance than commercial carbonate electrolytes and other reported ester-based electrolytes in both half and full cells. Electrochemical and spectroscopic characterization shows that the superior charging performance of the reported electrolyte is due to significantly reduced SEI resistance and charge transfer resistance. Cycling tests show remarkable stability in Li||graphite (gr) half cells, suggesting the potential of the electrolytes to enhance battery charging performance. LiFePO4 (LFP)||gr full cells were further tested, and it is found that the resistance of cells builds up during cycling due to gelation of the electrolyte, which limits the cycling performance of full cells. Potential strategies to address this limitation are discussed.

7.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi ; 36(7): 866-872, 2022 Jul 15.
Artigo em Chinês | MEDLINE | ID: mdl-35848184

RESUMO

Objective: To investigate the influence of axis pedicle and intra-axial vertebral artery (IAVA) alignment on C 2 pedicle screw placement by measuring the data of head and neck CT angiography. Methods: The axis pedicle diameter (D), isthmus height (H), isthmus thickness (T), and IAVA alignment types were measured in 116 patients (232 sides) who underwent head and neck CT angiography examinations between January 2020 and June 2020. Defined the IAVA offset direction by referencing the vertical line through the center of C 3 transverse foramen on the coronal scan, it was divided into lateral (L), neutral (N), and medial (M). Defined the IAVA high-riding degree by referencing the horizontal line through the outlet of the C 2 transverse foramen, it was divided into below (B), within (W), and above (A). The rate of pedicle stenosis, high-riding vertebral artery, and different IAVA types were calculated, and their relationships were analysed. Simulative C 2 pedicle screws were implanted by Mimics 19.0 software, and the interrelation among the rates of pedicle stenosis, high-riding vertebral artery, IAVA types, and vertebral artery injury were analyzed. Results: The rate of C 2 pedicle stenosis was 33.6% (78/232), and the rate of high-riding vertebral artery was 35.3% (82/232). According to the offset direction and the degree of riding, IAVA was divided into 9 types, among which the N-W type (29.3%) was the most, followed by the L-W type (19.0%) and the L-B type (12.9%), accounting for 60.9%. The vertebral artery injury rate of simulative implanted C 2 pedicle screws was 35.3% (82/232). The vertebral artery injury rate in patients with pedicle stenosis and high-riding vertebral artery was significantly higher than that who were not ( P<0.001). The rate of pedicle stenosis, high-riding vertebral artery, and vertebral artery injury were significantly different among IAVA types ( P<0.001), and M-A type was the most common. Conclusion: Vertebral artery injury is more common in pedicle stenosis and/or high-riding vertebral artery and/or IAVA M-A type. Preoperative head and neck CT angiography examination has clinical guiding significance.


Assuntos
Parafusos Pediculares , Vértebras Cervicais/cirurgia , Constrição Patológica , Humanos , Tomografia Computadorizada por Raios X , Artéria Vertebral/lesões , Artéria Vertebral/cirurgia
8.
ACS Cent Sci ; 8(6): 729-740, 2022 Jun 22.
Artigo em Inglês | MEDLINE | ID: mdl-35756376

RESUMO

Iron (Fe) metal batteries, such as Fe-ion batteries and all Fe flow batteries, are promising energy storage technologies for grid applications due to the extremely low cost of Fe and Fe salts. Nonetheless, the cycle life of Fe metal batteries is poor primarily due to the low Coulombic efficiency of the Fe deposition/stripping reaction. Current aqueous electrolytes based on Fe chloride or sulfate salts can only operate at a Coulombic efficiency of <91% under mild operation conditions (<5 mA/cm2), largely due to undesired hydrogen evolution reaction (HER). This work reports a series of novel Fe electrolytes, Fe electrolytes reinforced with Mg ions (FERMI) and Ca ions (FERCI), which have remarkably better Coulombic efficiency, higher conductivity, and faster deposition/stripping kinetics. By the addition of 4.5 M MgCl2 or CaCl2 into the baseline FeCl2 electrolyte, the Fe deposition/stripping efficiency can be significantly improved to 99.1%, which greatly boosts the cycling performance of Fe metal batteries in both half-cells and full-cells. Mechanistic studies reveal that the remarkably improved efficiency is due to a reduced amount of "dead Fe" as well as suppressed HER. By the combination of experiments and molecular dynamics and density functional theory computation, the electrolyte structure is revealed, and the mechanism for enhanced water reduction resistance is elucidated. These novel electrolytes not only enable a highly reversible Fe metal anode for low-cost energy storage technologies but also have the potential to address the HER side reaction problem in other electrochemical technologies based on aqueous electrolytes, such as CO2 reduction, NH3 synthesis, etc.

9.
J Comput Biol ; 29(9): 1022-1030, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-35749149

RESUMO

Coordinated hunting is widely observed in animals, and sharing rewards is often considered a major incentive for its success. While current theories about the role played by sharing in coordinated hunting are based on correlational evidence, we reveal the causal roles of sharing rewards through computational modeling with a state-of-the-art Multi-agent Reinforcement Learning (MARL) algorithm. We show that counterintuitively, while selfish agents reach robust coordination, sharing rewards undermines coordination. Hunting coordination modeled through sharing rewards (1) suffers from the free-rider problem, (2) plateaus at a small group size, and (3) is not a Nash equilibrium. Moreover, individually rewarded predators outperform predators that share rewards, especially when the hunting is difficult, the group size is large, and the action cost is high. Our results shed new light on the actual importance of prosocial motives for successful coordination in nonhuman animals and suggest that sharing rewards might simply be a byproduct of hunting, instead of a design strategy aimed at facilitating group coordination. This also highlights that current artificial intelligence modeling of human-like coordination in a group setting that assumes rewards sharing as a motivator (e.g., MARL) might not be adequately capturing what is truly necessary for successful coordination.


Assuntos
Inteligência Artificial , Caça , Algoritmos , Animais , Humanos , Aprendizagem , Recompensa
10.
Neurology ; 2022 Jun 22.
Artigo em Inglês | MEDLINE | ID: mdl-35732505

RESUMO

BACKGROUND AND OBJECTIVES: Whether acupuncture is effective for chronic tension-type headache (CTTH) is inconclusive. We aimed to examine the effectiveness of acupuncture with a follow-up period of 32 weeks. METHODS: We conducted a randomized controlled trial, and 218 participants who were diagnosed with CTTH were recruited from June 2017 to September 2020. The participants in the intervention group received 20 sessions of true acupuncture (TA group) over 8 weeks. The acupuncture treatments were standardized across participants, and each acupuncture site was needled to achieve deqi sensation. Each treatment session lasted 30 minutes. The participants in the control group received the same sessions and treatment frequency of superficial acupuncture (SA group)-defined as a type of sham control by avoiding deqi sensation at each acupuncture site. The main outcome was the responder rate at 16 weeks after randomization (week 16) and was followed up at week 32. A responder was defined as a participant who reported at least a 50% reduction in the monthly number of headache days (MHDs). RESULTS: Our study included 218 participants (mean age: 43.1 years, mean disease duration: 130 months, MHDs: 21.5 days). The responder rate was 68.2% in the TA group (n=110) versus 48.1% in the SA group (n=108) at week 16 (odds ratio, 2.65; 95%CI, 1.5 to 4.77; p<0.001); and it was 68.2% in the TA group versus 50% in the SA group at week 32 (odds ratio, 2.4; 95%CI, 1.36 to 4.3; p<0.001). The reduction in MHDs was 13.1±9.8 days in the TA group versus 8.8±9.6 days in the SA group at week 16 (mean difference, 4.3 days; 95%CI, 2.0 to 6.5; p<0.001), and the reduction was 14±10.5 days in the TA group versus 9.5±9.3 days in the SA group at week 32 (mean difference, 4.5 days; 95%CI, 2.1 to 6.8; p<0.001). Four mild adverse events were reported; three in the TA group versus one in the SA group. CONCLUSION: The 8-week TA treatment was effective for the prophylaxis of CTTH. Further studies might focus on the cost-effectiveness of the treatment. TRIAL: Registration Information: ClinicalTrials.gov: NCT03133884 (https://clinicaltrials.gov/ct2/show/NCT03133884) CLASSIFICATION OF EVIDENCE: This study provides Class I evidence that acupuncture (achieving deqi sensation) reduces mean headache days (per month) in patients with chronic tension-type headache.

11.
Small ; 18(29): e2201094, 2022 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-35695333

RESUMO

Developing new oxide solid electrolytes with fast Li-ion transport and high stability is an important step to realize high-performance solid-state Li-ion batteries. Hydrate materials containing confined water widely exist in nature or can be easily synthesized. However, they have seldom been explored as Li-ion solid electrolytes due to the stereotype that the presence of water limits the electrochemical stability window of a solid electrolyte. In this work, it is demonstrated that confined water can enhance Li-ion transport while not compromising the stability window of solid electrolytes using Li-H-Ti-O quaternary compounds as an example system. Three Li-H-Ti-O quaternary compounds containing different amounts of confined water are synthesized, and their ionic conductivity and electrochemical stability are compared. The compound containing structural pseudo-water is demonstrated to have an ionic conductivity that is 2-3 order of magnitude higher than the water-free Li4 Ti5 O12 and similar stability window. A solid-state battery is made with this new compound as the solid electrolyte, and good rate and cycling performance are achieved, which demonstrates the promise of using such confined-water-containing compounds as Li-ion solid electrolytes. The knowledge and insights gained in this work open a new direction for designing solid electrolytes for future solid-state Li-ion batteries. Broadly, by confining water into solid crystal structures, new design freedoms for tailing the properties of ceramic materials are introduced, which creates new opportunities in designing novel materials to address critical problems in various engineering fields.

12.
Cell Commun Signal ; 20(1): 82, 2022 06 03.
Artigo em Inglês | MEDLINE | ID: mdl-35659308

RESUMO

Distant spreading of metastatic tumor cells is still the leading cause of tumor death. Metastatic spreading is a complex process, in which epithelial-mesenchymal transition (EMT) is the primary and key event to promote it. Presently, extensive reviews have given insights on the occurrence of EMT at the primary tumor site that depends on invasive properties of tumor cells and the tumor-associated microenvironment. However, essential roles of circulation environment involved in tumor cell EMT is not well summarized. As a main constituent of the blood, platelet is increasingly found to work as an important activator to induce EMT. Therefore, this review aims to emphasize the novel role of platelet in EMT through signal communications between platelets and circulation tumor cells, and illustrate potent interventions aiming at their communications. It may give a complementary view of EMT in addition to the tissue microenvironment, help for better understand the hematogenous metastasis, and also illustrate theoretical and practical basis for the targeted inhibition. Video abstract.


Assuntos
Transição Epitelial-Mesenquimal , Neoplasias , Plaquetas/metabolismo , Humanos , Neoplasias/metabolismo , Microambiente Tumoral
13.
Circulation ; 146(2): 94-109, 2022 07 12.
Artigo em Inglês | MEDLINE | ID: mdl-35652342

RESUMO

BACKGROUND: Cardiovascular health (CVH) from young adulthood is strongly associated with an individual's future risk of cardiovascular disease (CVD) and total mortality. Defining epigenomic biomarkers of lifelong CVH exposure and understanding their roles in CVD development may help develop preventive and therapeutic strategies for CVD. METHODS: In 1085 CARDIA study (Coronary Artery Risk Development in Young Adults) participants, we defined a clinical cumulative CVH score that combines body mass index, blood pressure, total cholesterol, and fasting glucose measured longitudinally from young adulthood through middle age over 20 years (mean age, 25-45). Blood DNA methylation at >840 000 methylation markers was measured twice over 5 years (mean age, 40 and 45). Epigenome-wide association analyses on the cumulative CVH score were performed in CARDIA and compared in the FHS (Framingham Heart Study). We used penalized regression to build a methylation-based risk score to evaluate the risk of incident coronary artery calcification and clinical CVD events. RESULTS: We identified 45 methylation markers associated with cumulative CVH at false discovery rate <0.01 (P=4.7E-7-5.8E-17) in CARDIA and replicated in FHS. These associations were more pronounced with methylation measured at an older age. CPT1A, ABCG1, and SREBF1 appeared as the most prominent genes. The 45 methylation markers were mostly located in transcriptionally active chromatin and involved lipid metabolism, insulin secretion, and cytokine production pathways. Three methylation markers located in genes SARS1, SOCS3, and LINC-PINT statistically mediated 20.4% of the total effect between CVH and risk of incident coronary artery calcification. The methylation risk score added information and significantly (P=0.004) improved the discrimination capacity of coronary artery calcification status versus CVH score alone and showed association with risk of incident coronary artery calcification 5 to 10 years later independent of cumulative CVH score (odds ratio, 1.87; P=9.66E-09). The methylation risk score was also associated with incident clinical CVD in FHS (hazard ratio, 1.28; P=1.22E-05). CONCLUSIONS: Cumulative CVH from young adulthood contributes to midlife epigenetic programming over time. Our findings demonstrate the role of epigenetic markers in response to CVH changes and highlight the potential of epigenomic markers for precision CVD prevention, and earlier detection of subclinical CVD, as well.


Assuntos
Doenças Cardiovasculares , Doença da Artéria Coronariana , Adulto , Biomarcadores , Doenças Cardiovasculares/diagnóstico , Doenças Cardiovasculares/epidemiologia , Doenças Cardiovasculares/genética , Metilação de DNA , Nível de Saúde , Humanos , Incidência , Pessoa de Meia-Idade , Medição de Risco , Fatores de Risco , Adulto Jovem
14.
ACS Appl Mater Interfaces ; 14(22): 26014-26023, 2022 Jun 08.
Artigo em Inglês | MEDLINE | ID: mdl-35608943

RESUMO

Although numerous studies on polymeric protective films to stabilize lithium (Li)-metal electrodes have been reported, the construction of self-healing polymers that enables the long-term operation of Li-metal batteries (LMBs) at relatively low temperatures has rarely been demonstrated. Herein, a highly stretchable, autonomous self-healable, and ionic-conducting polymer network (SHIPN) is synthesized as an efficient protective film for LMBs. The network backbone, synthesized from copolymerization of poly(ethylene glycol)-mono-methacrylate (PEGMMA) and 2-[[(butylamino)carbonyl]oxy]ethyl acrylate (BCOE), is chemically cross-linked via diisocyanate. With SHIPN-modified electrodes, enhanced electrochemical performance can be achieved in Li/Cu, Li/Li, and Li/LiFePO4 (Li/LFP) cells. The SHIPN@Li/LFP cell delivers a capacity retention of 85.6% after 500 cycles at 5 °C, resulting from the low-temperature self-healability of SHIPN. In full cells with a high-mass-loading LFP cathode (∼17 mg cm-2), the capacity retention is at least 300% higher than that with a bare Li electrode. Further physical characterizations of electrodes confirm the effect of SHIPN in enhancing the interfacial stability and suppressing Li dendrite growth. Our results will provide insights into rationally designing soft and hybrid materials toward stable LMBs at different temperatures.

15.
Front Surg ; 9: 863718, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35620191

RESUMO

Intracranial aneurysms are vascular diseases characterized by local aneurysms of intracranial arteries. Their etiology involves a variety of environmental and genetic factors. Unruptured intracranial aneurysms (UIAs) are more common in intracranial aneurysms, but once an aneurysm is ruptured, the fatality rate and disability rate are extremely high. Therefore, accurate assessment of each step in the detection of intracranial aneurysms, assessment of the risk of rupture, formulation of treatment strategies, and treatment benefits will help to better treat the disease. At present, the treatment of intracranial aneurysms is limited. Except for surgical intervention, there are no other effective methods. Therefore, when a patient has a UIA, the formulation of treatment and management strategies is a difficult issue facing neurosurgery. This article introduces the choice of different treatment strategies for 3 patients with intracranial aneurysms complicated with other diseases and reviews the literature.

16.
J Food Biochem ; 46(9): e14235, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-35579221

RESUMO

It has been reported that the aqueous extract from Oxalis corniculate has excellent pharmacological effects, but its polysaccharide as the major ingredient in the aqueous extract has not been reported. When the temperature of 50°C, ultrasonic power of 270 W, time of 25 min, solid to liquid ratio of 30 ml·g-1 , the optimal O. corniculate polysaccharide (OCP) yield was 9.45%. The physicochemical properties indicated that OCP-3, as the major fraction of OCP, was an acidic polysaccharide with 31.5 kDa, and it mainly consisted of arabinose (47.83%), galacturonic acid (17.81%), and galactose (14.25%). In addition, OCP-3 displayed an excellent antioxidant activity in vitro, including scavenging free radical, anti-lipid peroxidation, and protecting plasmid DNA from oxidative damage. Meanwhile, OCP-3 significantly reduced the levels of malondialdehyde and protein carbonyl by significantly increasing the activity of superoxide dismutase, catalase, and glutathione peroxidase, which protected the HEK 293 cell and Caenorhabditis elegans from oxidative damage. All the results suggested that OCP-3 might be the major active ingredient of the aqueous extract from O. corniculate, and OCP-3 might be a potent antioxidant supplement in the food, cosmetics, and medical industries. PRACTICAL APPLICATIONS: Oxalis corniculate is a kind of wild vegetable and ethnomedicine, and it is widely distributed in temperate zones. Unfortunately, its utilization rate is low compared to its yield. Our research suggested that the polysaccharide of OCP-3 from O corniculate might be used as a potent antioxidant supplement in the food, cosmetics, and medical industries.


Assuntos
Antioxidantes , Oxalidaceae , Ácidos , Antioxidantes/química , Células HEK293 , Humanos , Peroxidação de Lipídeos , Oxalidaceae/química , Oxalidaceae/metabolismo , Polissacarídeos/química , Polissacarídeos/farmacologia
17.
Materials (Basel) ; 15(10)2022 May 11.
Artigo em Inglês | MEDLINE | ID: mdl-35629472

RESUMO

Uniaxial and notched tension samples are utilized to investigate the damage and failure of titanium alloy Ti6Al4V. The strain fields on the samples are obtained by the digital image correlation (DIC) method. Strain localization occurs before fracturing in all samples, and the width and size of the localized zone are characterized. Slant fractures are observed in uniaxial and notched tension specimen, which indicate that the initiation and propagation of cracks in thin sheet specimens are highly affected by the shear stress. Numerical simulations were performed for identification of hybrid hardening laws, and the results were compared with the experiments. The influence of the stress triaxiality on damage mechanism of Ti6Al4V was analyzed by observation of the specimen fracture surfaces using SEM. The results show that a higher stress triaxiality facilitates the formation and growth of micro-voids, which leads to a decrement of strain at failure.

18.
Spectrochim Acta A Mol Biomol Spectrosc ; 277: 121279, 2022 Sep 05.
Artigo em Inglês | MEDLINE | ID: mdl-35512446

RESUMO

The feasibility of laser cooling of AuF molecule and its cation are investigated from vibrational and rotational perspectives. The spectroscopy of AuF molecule and AuF+ molecular cation are obtained by the method of multireference configuration interaction plus Davidson correction (MRCI + Q) and spin-orbit coupling (SOC) effect. On account of the accurate molecular spectroscopy and the transition dipole moment, the Franck-Condon factors and radiative lifetimes of AuF molecule and AuF+ molecular cation are calculated. Comparing the criterias of laser cooling candidate molecules, the AuF is an excellent candidate for laser cooling and while AuF+ is not sutable. The b3Π0+ ↔ Χ1Σ+0+ transition of AuF is selected for laser cooling and an optical cycling scheme is proposed. The scheme possesses highly diagonally Franck-Condon factors and the scattered photons achieve âˆ¼ 104. Furthermore, the rotational transition analysis is also included in our work and found that its Franck Condon factors and Einstein coefficients are undistorted. Our work could provide theoretical support and accelerate the laser cooling of AuF molecules in experiments.

19.
Brain Res ; 1786: 147902, 2022 07 01.
Artigo em Inglês | MEDLINE | ID: mdl-35381215

RESUMO

BACKGROUND: In traumatic spinal cord injury (SCI), secondary injuries, including cellular death, mitochondrial dysfunction, and vascular injury, have been considered as important causes of impaired functional recovery after SCI. Postinjury angiogenesis has been considered to be a potential strategy for SCI treatment. New-born vessels may play a key role in nerve regeneration, which indicates the importance of angiogenesis in nerve regeneration. Recent studies have revealed the crosstalk between reactive oxygen species (ROS) and angiogenesis. As the main source of cellular ROS, mitochondria have been proven to be essential to the angiogenesis process. METHODS: SCI was established in a T10 clip-compression animal model. Then, the animals received an intraperitoneal injection of MitoQ (5 mg/kg/d) on Days 0, 1, and 2 after surgery. The Basso Mouse Scale (BMS) score and footprint analysis (CatWalk analysis) were performed to evaluate functional recovery after SCI. Immunofluorescence and fluorescence assays (LEL-FITC/CD31/Iba-1/Neurofilament) were performed to evaluate angiogenesis, microglia activation and neural regeneration. RT-qPCR (VEGFR-1, VEGFR-2 and VEGFA) was performed to evaluate angiogenesis-related factor in injured spinal cord. ATP production assay and western-blotting assay (Mfn-1 and Drp-1) were performed to evaluate mitochondrial function in the injured spinal cord. BV2 cells were used as in vitro cell model. After receiving TBHP or TBHP-MitoQ treatment, ELISA and immunofluorescence assays were used to evaluate the level of VEGFA secretion from BV2 cells. A coculture system of HUVECs and BV2 cells was established. Tube formation assays and immunofluorescence assays (CD31) were performed on HUVECs in a coculture system to evaluate angiogenesis promotion. ATP production assays were performed to evaluate mitochondrial function in BV2 cells. MitoSOX Red and DCFH-DA staining were performed to evaluate mitochondrial and cellular ROS. RESULTS: In vitro MitoQ promoted the secretion of VEGFA from BV2 cells, which was verified through ELISA and immunofluorescence assays. The angiogenic promotion of MitoQ-treated BV2 cells was evaluated by tube formation and immunofluorescence assays (CD31) in a coculture system of BV2 cells and HUVECs. MitoQ inhibited cellular and mitochondrial-derived ROS in TBHP-treated BV2 cells. ATP production was increased in MitoQ-treated BV2 cells. To verify MitoQ's effect in vivo, a T10 clip-compression animal model was established successfully. MitoQ significantly promoted functional recovery, as shown by the BMS assay and gait analysis. The promotion of neural regeneration was identified through immunofluorescence assay of neurofilament. Immunofluorescence and fluorescence assays (LEL-FITC/CD31/Iba-1) and RT-qPCR (VEGFR-1, VEGFR-2 and VEGFA) indicated that MitoQ could promote angiogenesis and inhibit macrophage/microglia activation in lesion-site after SCI. Enhanced ATP production and increased Mfn-1 with decreased Drp-1 protein expression showed MitoQ could promote mitochondrial function in SCI. CONCLUSION: The mitochondrial-specific antioxidant MitoQ promotes functional recovery and tissue preservation through the enhancement of angiogenesis with the modification of mitochondrial function after SCI.


Assuntos
Traumatismos da Medula Espinal , Receptor 1 de Fatores de Crescimento do Endotélio Vascular , Trifosfato de Adenosina/metabolismo , Animais , Antioxidantes/metabolismo , Antioxidantes/farmacologia , Modelos Animais de Doenças , Fluoresceína-5-Isotiocianato/metabolismo , Fluoresceína-5-Isotiocianato/farmacologia , Camundongos , Mitocôndrias/metabolismo , Espécies Reativas de Oxigênio/metabolismo , Recuperação de Função Fisiológica/fisiologia , Medula Espinal/metabolismo , Receptor 1 de Fatores de Crescimento do Endotélio Vascular/metabolismo , Receptor 1 de Fatores de Crescimento do Endotélio Vascular/farmacologia , Receptor 2 de Fatores de Crescimento do Endotélio Vascular/metabolismo
20.
Front Nutr ; 9: 741630, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35399675

RESUMO

Food is an important factor affecting the treatment of patients with early gastric cancer (EGC). We have established a hospital cohort to guide dietary patterns and observe the health status of patients with EGC after endoscopic submucosal dissection (ESD) after dietary modification. A total of 273 patients with EGC who underwent ESD were recruited to the cohort. They were given dietary instruction and education through a dietary manual and were followed up for 12 months. If the dietary pattern changed to the "traditional food" pattern (high consumption of vegetables, wheat products, and red meat) after the nutritional guidance, subjects were defined as the improvement diet group. Dietary patterns focused on "alcohol and fish" (drink a lot of wine and beer and eating freshwater and marine fish) or "coarse cereals" (mainly whole grains, beans and poultry) were the main ones in the unimproved diet group. The nutritional status, gastric mucosa, and gastrointestinal symptoms of the two groups of patients before and after the dietary instruction were compared. Compared with the unimproved diet group, the endoscopic performance score and the symptom score in the improved diet group were decreased by an average of 1.31 and 1.90, respectively. Except for lymphocyte count (P = 0.227), total protein (P < 0.000), albumin (P = 0.003), globulin (P = 0.014), red blood cell count (P < 0.000), and hemoglobin (P < 0.000) values were improved to varying degrees. After changing the diet, the intake of wheat products and vegetables in the improved diet group increased by 15.58 and 17.52%, respectively, while the intake of alcohol, fish, and pickled products was reduced by 43.36, 36.43, and 31.41%, respectively. After 1 year of dietary adjustment, the nutritional status, gastric mucosa, and gastrointestinal symptoms of patients with EGC after ESD eating the "traditional food" diet were all improved.

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