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1.
Zhonghua Yu Fang Yi Xue Za Zhi ; 53(10): 1012-1017, 2019 Oct 06.
Artigo em Chinês | MEDLINE | ID: mdl-31607047

RESUMO

Objective: Using three models too estimate excess mortality associated with influenza of Shanxi Province during 2013-2017. Methods: Mortality data and influenza surveillance data of 11 cities of Shanxi Province from the 2013-2014 through 2016-2017 were used to estimate influenza-associated all cause deaths, circulatory and respiratory deaths and respiratory deaths. Three models were used: (i) Serfling regression, (ii)Poisson regression, (iii)General line model. Results: The total reported death cases of all cause were 157 733, annual death cases of all cause were 39 433, among these cases, male cases 93 831 (59.50%), cases above 65 years old 123 931 (78.57%). Annual influenza-associated excess mortality, for all causes, circulatory and respiratory deaths, respiratory deaths were 8.62 deaths per 100 000, 6.33 deaths per 100 000 and 0.68 deaths per 100 000 estimated by Serfling model, respectively; and 21.30 deaths per 100 000, 16.89 deaths per 100 000 and 2.14 deaths per 100 000 estimated by General line model, respectively; and 21.76 deaths per 100 000, 17.03 deaths per 100 000 and 2.05 deaths per 100 000, estimated by Poisson model, respectively. Influenza-related excess mortality was higher in people over 75 years old; influenza-associated excess mortalityfor all causes, circulatory and respiratory deaths, respiratory deaths were 259.67 deaths per 100 000, 229.90 deaths per 100 000 and 32.63 deaths per 100 000, estimated by GLM model, respectively; and 269.49 deaths per 100 000, 233.69 deaths per 100 000 and 31.27 deaths per 100 000, estimated by Poisson model,respectively. Conclusion: Excess mortality associated with influenza mainly caused by A (H3N2), Influenza caused the most associated death amongold people.


Assuntos
Influenza Humana/epidemiologia , China/epidemiologia , Cidades , Humanos , Vírus da Influenza A Subtipo H3N2 , Mortalidade/tendências
2.
Neoplasma ; 66(4): 532-542, 2019 07 23.
Artigo em Inglês | MEDLINE | ID: mdl-30943748

RESUMO

Long noncoding RNAs (lncRNAs) play crucial roles in the development of human cancers. LncRNA small nucleolar RNA host gene 20 (SNHG20) has been reported to be an oncogene in several cancers, whereas the specific role of SNHG20 in glioblastoma is unclear. In this study, we found that SNHG20 was significantly upregulated in glioblastoma tissues and cell lines. Survival analysis suggested that high expression of SNHG20 indicated the low overall survival rate of glioblastoma patients. Subsequently, gain or loss-of-function assays were carried out to examine the effect of SNHG20 on glioblastoma cell proliferation and apoptosis. We found that SNHG20 knockdown obviously suppressed cell proliferation, increased cell apoptosis and impaired stem properties, while SNHG20 overexpression led to the opposite results. In vivo experiment demonstrated that knockdown of SNHG20 efficiently suppressed cell growth in vivo. Furthermore, western blotting demonstrated that the PI3K/Akt/mTOR signaling pathway was activated by SNHG20 in glioblastoma cells. At last, rescue assays validated that PI3K/Akt/mTOR signaling pathway involved in the glioblastoma progression mediated by SNHG20. Taken together, this study revealed that SNHG20 regulated PI3K/Akt/mTOR signaling pathway to promote tumorigenesis and stemness of glioblastoma.


Assuntos
Glioblastoma/patologia , Células-Tronco Neoplásicas/citologia , RNA Longo não Codificante/genética , Transdução de Sinais , Carcinogênese , Linhagem Celular Tumoral , Regulação Neoplásica da Expressão Gênica , Técnicas de Silenciamento de Genes , Humanos , Fosfatidilinositol 3-Quinases , Proteínas Proto-Oncogênicas c-akt , Serina-Treonina Quinases TOR
3.
Zhonghua Yi Xue Za Zhi ; 98(30): 2407-2413, 2018 Aug 14.
Artigo em Chinês | MEDLINE | ID: mdl-30138985

RESUMO

Objective: To study the role of chemerin in the development and progression of non-alcoholic fatty liver disease (NAFLD) rats complicated with prediabetes and explore the effect of sitagliptin on the expression of chemerin. Methods: The model of NAFLD and prediabetic rats was established. The rats were then randomly divided into normal group, model group and intervention group. Sitagliptin intervention was performed for 8 weeks after 8 weeks's feeding with high-fat diet. After that, the level of blood glucose, insulin and chemerin was measured. Cytological changes of liver, omentum and epididymal adipose tissue were observed by HE staining. The distribution of chemerin in the tissues was observed by immunohistochemistry. The mRNA and protein expression of chemerin and chemokine-like receptor 1 (chemR23) in liver and adipose tissue were detected by RT-PCR and Western blotting. Results: After 8 weeks of sitagliptin treatment, compared with the normal group(n=8), serum chemerin in the model group (n=6) increased[(35.19±3.86) ng/L vs (29.90±2.17) ng/L, P=0.046)]. Serum chemerin in the intervention group (n=6) was lower than that of the normal group[(23.20±1.89) ng/L vs (29.90±2.17) ng/L, P=0.013)]. Compared with the normal group, the mRNA and protein expression of chemerin in the liver and omentum adipose tissue of the model group increased (P<0.05). The expression amount of the omental adipose tissue was more than that of the liver(P<0.05). The mRNA expression of chemR23 both in liver and omental adipose tissue increased (P<0.05), and the expression amount of the liver was more than that of omental adipose tissue. The levels of fasting blood glucose[(5.72 ±1.36)mmol/L vs(3.77±0.77)mmol/L, P=0.002], total cholesterol[(1.53±0.09)mmol/L vs (1.23±0.17)mmol/L, P=0.032], aspartate aminotransferase[(319.8±104.4)U/L vs (195.0±25.0) U/L, P=0.016]in the model group were significantly higher than those in the normal group. The differences between the intervention group and the normal group was not significant. But the level of fasting blood glucose[(4.33±0.39)mmol/L vs (5.72±1.36)mmol/L, P=0.019], total cholesterol[(1.23±0.17)mmol/L vs (1.53±0.09)mmol/L, P=0.047]and aspartate aminotransferase[(198.4±22.8)U/L vs (319.8±104.4)U/L, P=0.014)]of the intervention group was significantly lower than those of the model group. Conclusions: Increasing expression of serum chemerin is consistent with hepatic steatosis, suggesting that chemerin can serve as a serological warning indicator for NAFLD complicated with pre-diabetes. Sitagliptin affects the mRNA and protein expression of chemerin and its receptor chemR23 in steatosis liver. This may provide a research direction for the pathophysiology and treatment of NAFLD.


Assuntos
Hepatopatia Gordurosa não Alcoólica , Tecido Adiposo , Animais , Aspartato Aminotransferases , Glicemia , Quimiocinas , Dieta Hiperlipídica , Modelos Animais de Doenças , Insulina , Resistência à Insulina , Peptídeos e Proteínas de Sinalização Intercelular , Fígado , Estado Pré-Diabético , RNA Mensageiro , Ratos , Ratos Sprague-Dawley , Fosfato de Sitagliptina
4.
Eur Rev Med Pharmacol Sci ; 21(23): 5445-5450, 2017 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-29243788

RESUMO

OBJECTIVE: To explore the effect of spontaneous reperfusion (SR) on three-dimensional myocardial strain in patients with acute anterior myocardial infarction by three-dimensional speckle tracking imaging (3D-STI) technology. PATIENTS AND METHODS: Patients diagnosed with acute anterior myocardial infarction during 2013 to 2016 were consecutively selected and divided into SR group and non-spontaneous reperfusion (Non-SR) group based on whether there was SR. Patients in both groups received direct percutaneous coronary intervention (PCI) in time window. Baseline information, patency rates of culprit vessel, durations of operation, intraoperative non-reflow phenomenon ratios, and thrombolysis in myocardial infarction (TIMI) blood flows after reperfusion of patients in each group were recorded. Hospital stays of patients were compared between the two groups. Before discharge, left ventricular ejection fraction (LVEF) and left ventricular end-diastolic diameter (LVEDd) were measured. Global longitudinal strain (GLS), global radial strain (GRS), and global circumferential strain (GCS) of left ventricular (LV) were also detected by 3D-STI, so as to assess movement situations of ventricular wall and cardiac muscle in occlusive blood vessel distribution area. LVEF, LVEDd and various 3D-STI parameters were reexamined and compared one year after discharge. RESULTS: There were no significant differences between the Non-SR group and the SR group regarding the patency rate of culprit vessel, duration of operation, intraoperative non-reflow phenomenon ratio, TIMI blood flow after reperfusion, and LVEDd (p>0.05). Both LVEF before discharge and LV three-dimensional strain indexes of the SR group, were clearly higher than those of the Non-SR group (p<0.05). After one-year follow-up, the SR group had a remarkably lower LVEDd than the Non-SR group (p<0.05). LVEF of the SR group was overtly higher than that of the Non-SR group (p<0.05). LV three-dimensional strain indexes were also distinctly higher in the SR group than in the Non-SR group (p<0.05). There were good correlations between GLS, GRS, GCS and LVEF (r values were -0.620, -0.674 and 0.723, respectively). CONCLUSIONS: SR can improve nosocomial and long-term LV remodeling in patients with acute anterior myocardial infarction, and 3D-STI is able to assess ventricular remodeling after myocardial infarction.


Assuntos
Infarto do Miocárdio/fisiopatologia , Função Ventricular Esquerda , Ecocardiografia Tridimensional , Feminino , Ventrículos do Coração/diagnóstico por imagem , Ventrículos do Coração/fisiopatologia , Humanos , Processamento de Imagem Assistida por Computador , Tempo de Internação , Masculino , Infarto do Miocárdio/diagnóstico por imagem , Infarto do Miocárdio/terapia , Intervenção Coronária Percutânea , Reperfusão , Remodelação Ventricular
5.
Artigo em Chinês | MEDLINE | ID: mdl-28355708

RESUMO

Objective: To observe the effects of extract of Ginkgo biloba (Ginaton) on magnetic resonance imaging (MRI) and electroencephalography (EEG) in patients with delayed encephalopathy after acute carbon monoxide poisoning. Methods: The 84 patients with delayed encephalopathy after acute carbon monoxide poisoning treated in our hospital from Jan. 2011 to Apr. 2016 were randomly divied into therapy group and observation group. The therapy group received routine treatments of hyperbaric oxygen, cure cerebral edema and promote brain cell metabolism, and observation group was given intravenous injection (intravenous drip) Ginaton 70 mg (adding 0.9% sodium chloride injection 250 ml) , once a day, 2 weeks for one therapeutic course. The changes of MRI and EEG before and after treatment between therapy group and observation group were observed. Results: In the observation group, the white matter and globus pallidus lesions of 14 d after treatment were smaller than those in the treatment group, and the abnormal signal intensity was decreased. At 14 days after treatment the improvement of EEG in observation group were better than therapy group (P<0.05) . Conclusion: Early treatment of extract of Ginkgo biloba (Ginaton) in delayed encephalopathy after acute carbon monoxide poisoning can effectively improve lesion and signal on MRI and abnormal rate on EEG. It has a certain therapeutic effect in clinical.


Assuntos
Encefalopatias/etiologia , Encéfalo/diagnóstico por imagem , Intoxicação por Monóxido de Carbono/complicações , Medicamentos de Ervas Chinesas/farmacologia , Eletroencefalografia/métodos , Ginkgo biloba , Imagem por Ressonância Magnética/métodos , Humanos
6.
Eur J Clin Microbiol Infect Dis ; 35(11): 1877-1881, 2016 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-27530532

RESUMO

By comparing the safety and efficacy of 500 mg of oral levofloxacin for 3 days with those of intravenous antibiotics for 3 days in the prevention of infectious complications of ultrasound-guided transrectal prostate biopsy (TPB), we provided a safe and cost-effective infection preventive protocol for TPB in China. A total of 801 patients with indications for TPB in 12 centers were randomized into two groups from October 2011 to December 2015. Patients in the test group (n = 392) took 500 mg of oral levofloxacin for 3 days. Patients in the control group (n = 409) underwent intravenous antibiotics according to the traditional habits of the center for 3 days. All patients underwent ultrasound-guided TPB. Infectious complications were compared between the two groups. Different kinds of antibiotic were used in the control group. Comparing the two groups, the mean patient age was 70.6 ± 14.0 and 70.5 ± 14.0 years. The incidence of total infectious complications was 4.6 % (18/392) and 4.4 % (18/409) respectively, the incidence of asymptomatic bacteriuria was 3.1 % (12/392) and 2.7 % (11/409), the incidence of symptomatic urinary tract infection was 0.0 % and 0.2 % (1/409), the incidence of fever was 0.8 % (3/392) and 0.5 % (2/409), the incidence of bacteremia was 0.5 % (2/392) and 0.0 %, and the incidence of urosepsis was 0.3 % (1/392) and 1.0 % (4/409) respectively (all P > 0.05). The selection of antibacterial agents for TPB is in ca haotic condition in China. Oral levofloxacin at 500 mg once daily for 3 days is a safe, convenient, and cost-effective infection preventive protocol for TPB in China.


Assuntos
Antibacterianos/administração & dosagem , Antibioticoprofilaxia/métodos , Infecções Bacterianas/prevenção & controle , Biópsia Guiada por Imagem/efeitos adversos , Biópsia Guiada por Imagem/métodos , Levofloxacino/administração & dosagem , Neoplasias da Próstata/diagnóstico , Administração Intravenosa , Administração Oral , Idoso , Idoso de 80 Anos ou mais , Infecções Bacterianas/epidemiologia , China , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Cuidados Pré-Operatórios/métodos , Estudos Prospectivos , Resultado do Tratamento
7.
Zhonghua Xin Xue Guan Bing Za Zhi ; 44(5): 443-9, 2016 May 24.
Artigo em Chinês | MEDLINE | ID: mdl-27220582

RESUMO

OBJECTIVE: To explore the potential role and mechanism of microRNA(miR)-30a in myocardial fibrosis after myocardial infarction (MI). METHODS: Rats were randomly divided into 1 week MI group (n=11), 2 weeks MI group (n=13) and 4 weeks MI group (n=15) by applying random number table after left anterior descending coronary artery ligation. Rats in Sham group were examined at respective time points (n=16). Heart function was monitored by echocardiography. Myocardial collagen volume fraction (CVF) was determined on Masson stained sections. Myocardial expression of collagen Ⅰ and Ⅲ was determined by immunohistochemistry. The myocardial mRNA level of miR-30a, TGF-ß1 and CTGF were detected by real time-quantitative PCR analysis. The myocardial protein levels of TGF-ß1 and CTGF were measured by Western blot analysis. RESULTS: The LVEDD ((8.37±0.58) mm) and LVESD ((6.12±0.82) mm) in 4 weeks MI group were significantly higher than those in Sham group ((6.08±0.57) mm, (4.17±0.60) mm), all P<0.01. The FS ((27.0±3.9) %) and LVEF ((51.0±6.3) %) in 4 weeks MI group were significantly lower than those in Sham group ((47.0±2.1) %, (82.0±2.3)%), all P<0.01. The level of myocardial CVF in 1 week MI group, 2 weeks MI group and 4 weeks MI group were significantly higher than in Sham group (all P<0.01) in a time-dependent manner. The level of myocardial collagen Ⅰ and Ⅲ was increased gradually from 1 week to 4 weeks post MI compared with Sham group (all P<0.01). The collagen Ⅰ/Ⅲ ratio was similar between 1 week MI group and Sham group (P=0.58), however, which was significantly higher in 2 weeks MI group and 4 weeks MI group compared with Sham group (all P<0.01), and the ratio was significantly higher in 4 weeks MI group than 2 weeks MI group (P<0.01). The level of miR-30a was significantly and gradually reduced in all MI groups compared with Sham group (all P<0.01). The mRNA and protein levels of TGF-ß1 and CTGF were significantly and gradually increased after MI compared with Sham group (all P<0.001). CONCLUSIONS: Our results indicate that overexpression of miR-30a after MI might be a potential strategy for suppressing myocardial fibrosis by modulating the mRNA and protein levels of TGF-ß1 and CTGF.


Assuntos
MicroRNAs/metabolismo , Infarto do Miocárdio/metabolismo , Miocárdio/patologia , Animais , Cardiomiopatias , Colágeno Tipo I/metabolismo , Colágeno Tipo III/metabolismo , Fator de Crescimento do Tecido Conjuntivo/metabolismo , Ecocardiografia , Infarto do Miocárdio/patologia , RNA Mensageiro/metabolismo , Distribuição Aleatória , Ratos , Fator de Crescimento Transformador beta1/metabolismo
8.
Int J Tuberc Lung Dis ; 19(2): 223-30, 2015 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-25574923

RESUMO

OBJECTIVE: To describe the quality of life (QOL) of the migrant population with pulmonary tuberculosis (PTB) in West China, and identify factors associated with QOL. METHODS: A pilot investigation was conducted among 103 migrant individuals with PTB in Nanchong Region, Sichuan Province, China. The QOL and social support of the patients were investigated using a short version of the World Health Organization Quality of Life questionnaire and the Social Support Rating Scale, respectively. RESULTS: The mean scores of the QOL of the migrant population were respectively 12.1, 12.9 and 11.7 for the physical, psychological and environmental domains; these were significantly lower than those of the general Chinese population. Non-parametric tests detected the significant effects of the following: 1) educational levels on all domains, including social relationship; 2) age on all domains, except psychological; 3) personal income on the physical and environmental domains; and 4) subjective support on all domains, except psychological. Multivariate logistic regression analyses confirmed that educational levels and subjective support were significantly associated with the global health status of the migrant population. CONCLUSIONS: The QOL of patients with TB among the migrant population in West China was poor; education and subjective support were important influential factors.


Assuntos
Qualidade de Vida , Migrantes/estatística & dados numéricos , Tuberculose Pulmonar/epidemiologia , Adolescente , Adulto , China/epidemiologia , Escolaridade , Feminino , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Projetos Piloto , Apoio Social , Estatísticas não Paramétricas , Inquéritos e Questionários , Tuberculose Pulmonar/psicologia , Adulto Jovem
9.
Int J Infect Dis ; 15(9): e594-600, 2011 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-21715206

RESUMO

OBJECTIVE: To evaluate the efficacy and safety of adjunctive therapy using interferon-gamma (IFN-γ; an immunomodulator) for the treatment of pulmonary tuberculosis (TB). METHODS: We conducted a systematic review of controlled clinical trials that compared anti-TB drugs in combination with IFN-γ with the same anti-TB drugs alone for the treatment of pulmonary TB. RESULTS: Nine trials were identified, with IFN-γ being aerosolized or administered subcutaneously in one trial, aerosolized only in five trials, and administered intramuscularly in three trials. The methodology quality of all trials was rated 'C'. Meta-analysis of the trials with aerosolized IFN-γ showed statistical benefits on sputum negative conversion and chest radiograph: the pooled relative risk (RR) for conversion was 1.97 (95% confidence interval (CI) 1.20-3.24, p=0.008) after 1 month of treatment, 1.74 (95% CI 1.30-2.34, p=0.0002) after 2 months of treatment, 1.53 (95% CI 1.16-2.01, p=0.003) after 3 months of treatment, 1.57 (95% CI 1.20-2.06, p=0.001) after 6 months of treatment, and 1.55 (95% CI 1.17-2.05, p=0.002) at the end of treatment; the pooled RR for the chest radiograph was 1.38 (95% CI 1.10-1.17, p=0.006) at the end of treatment. For intramuscularly administered IFN-γ, meta-analysis of three trials showed its significant improvement on sputum negative conversion after 2 months of treatment. A randomized controlled trial with aerosolized and subcutaneously administered IFN-γ reported significant reductions in the symptoms of fever, wheeze, and night sweats in the IFN-γ-treated groups compared with the control group after 1 month of treatment. No patients discontinued treatment because of adverse effects caused by IFN-γ. CONCLUSION: Adjuvant therapy using IFN-γ, especially by aerosol, might be beneficial to TB patients, but large randomized controlled trials are needed for further evaluation of its efficacy and safety considering the quality of the trials analyzed.


Assuntos
Adjuvantes Imunológicos/uso terapêutico , Interferon gama/uso terapêutico , Tuberculose Pulmonar/tratamento farmacológico , Adjuvantes Imunológicos/efeitos adversos , Antituberculosos/uso terapêutico , Ensaios Clínicos como Assunto , Humanos , Interferon gama/efeitos adversos , Radiografia , Recidiva , Resultado do Tratamento , Tuberculose Pulmonar/diagnóstico por imagem , Tuberculose Pulmonar/microbiologia
10.
Int J Tuberc Lung Dis ; 13(7): 810-9, 2009 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-19555529

RESUMO

OBJECTIVE: To evaluate the efficacy and safety of rifapentine (RPT) vs. rifampicin (RMP) for the treatment of pulmonary tuberculosis (PTB). DESIGN: Systematic review of randomised controlled trials (RCTs) that compared combination drug regimens containing RPT with those containing RMP for the treatment of drug-susceptible or previously untreated PTB. RESULTS: Nine RCTs were identified. Statistically significant differences were not found in the cure rates, severe adverse effects, severe hepatotoxicity or bacteriological relapse rates between the regimens containing once- or twice-weekly RPT and those containing daily RMP for human immunodeficiency virus (HIV) negative patients, but were found in the bacteriological relapse rates between regimens containing once-weekly or less frequent RPT and those containing twice- or thrice-weekly RMP: the pooled relative risks in the two subgroups were respectively 1.71 (95%CI 1.13-2.58, P = 0.01) and 2.44 (95%CI 1.15-5.18, P = 0.02). The trial for HIV-positive patients did not show significant differences in the sputum conversion rate, severe adverse effects or bacteriological relapse rate between the RPT- and RMP-containing regimens; four of the five relapses were associated with the RPT-containing regimen, but none of the three relapses with the RMP-containing regimen produced monoresistance to rifamycin (RIF). CONCLUSION: Once- or twice-weekly RPT and daily RMP have similar efficacy and safety for the treatment of HIV-negative PTB, but once-weekly or less frequent use of RPT, in comparison with twice- or thrice-weekly RMP, increases the risk of bacteriological relapse. RPT might increase the risk of resistance to RIF in HIV-positive patients.


Assuntos
Antituberculosos/uso terapêutico , Rifampina/análogos & derivados , Rifampina/uso terapêutico , Tuberculose Pulmonar/tratamento farmacológico , Antituberculosos/efeitos adversos , Humanos , Ensaios Clínicos Controlados Aleatórios como Assunto , Rifampina/efeitos adversos
11.
Diabetologia ; 52(5): 912-20, 2009 May.
Artigo em Inglês | MEDLINE | ID: mdl-19224198

RESUMO

AIMS/HYPOTHESIS: Carnitine palmitoyltransferase-1 (CPT1)c is a novel isoform in the CPT1 family and is found specifically in the brain. Cpt1c knockout (KO) mice are more susceptible to high-fat diet (HFD)-induced obesity. However, the underlying mechanism of this phenotype and the question of whether CPT1c is involved in the pathogenesis of diet-induced insulin resistance are unclear. METHODS: To assess the potential role of CPT1c in the regulation of whole-body glucose homeostasis, we generated Cpt1c KO mice and challenged them with HFD or standard chow. Glucose homeostasis of each group was assessed weekly. RESULTS: After 8 weeks of HFD feeding, Cpt1c KO mice developed a phenotype of more severe insulin resistance than that in wild-type controls. The increased susceptibility of Cpt1c KO mice to HFD-induced insulin resistance was independent of obesity. Impaired glucose tolerance in Cpt1c KO mice was attributable to elevated hepatic gluconeogenesis and decreased glucose uptake in skeletal muscle. These effects correlated with decreased hepatic and intramuscular fatty acid oxidation and expression of oxidative genes as well as with elevated triacylglycerol content in these tissues. Interestingly, Cpt1c deletion caused a specific elevation of hypothalamic CPT1a and CPT1b isoform expression and activity. We demonstrated that elevated plasma NEFA concentration is one mechanism via which this compensatory effect is induced. CONCLUSIONS/INTERPRETATION: These results further establish the role of CPT1c in controlling whole-body glucose homeostasis and in the regulation of hypothalamic Cpt1 isoform expression. We identify changes in hepatic and skeletal muscle glucose metabolism as important mechanisms determining the phenotype of Cpt1c KO mice.


Assuntos
Carnitina O-Palmitoiltransferase/genética , Gorduras na Dieta/efeitos adversos , Gluconeogênese/fisiologia , Intolerância à Glucose/enzimologia , Intolerância à Glucose/etiologia , Glucose/metabolismo , Fígado/metabolismo , Músculo Esquelético/metabolismo , Animais , Sequência de Bases , Peso Corporal , Carnitina O-Palmitoiltransferase/deficiência , Colesterol/sangue , Intolerância à Glucose/metabolismo , Teste de Tolerância a Glucose , Heterozigoto , Resistência à Insulina/genética , Masculino , Camundongos , Camundongos Knockout , Dados de Sequência Molecular , Obesidade/enzimologia , Obesidade/etiologia , Obesidade/metabolismo , Interferência de RNA , RNA Mensageiro/genética , Triglicerídeos/sangue
12.
J Hazard Mater ; 163(2-3): 823-8, 2009 Apr 30.
Artigo em Inglês | MEDLINE | ID: mdl-18718710

RESUMO

Concrete waste constitutes the major proportion of construction waste at about 50% of the total waste generated. An effective way to reduce concrete waste is to reuse it as recycled aggregate (RA) for the production of recycled aggregate concrete (RAC). This paper studies the physio-chemical reactions of cement paste around aggregate for normal aggregate concrete (NAC) and RAC mixed with normal mixing approach (NMA) and two-stage mixing approach (TSMA) by differential scanning calorimetry (DSC) and scanning electron microscopy (SEM). Four kinds of physio-chemical reactions have been recorded from the concrete samples, including the dehydration of C(3)S(2)H(3), iron-substituted ettringite, dehydroxylation of CH and development of C(6)S(3)H at about 90 degrees C, 135 degrees C, 441 degrees C and 570 degrees C, respectively. From the DSC results, it is confirmed that the concrete samples with RA substitution have generated less amount of strength enhancement chemical products when compared to those without RA substitution. However, the results from the TSMA are found improving the RAC quality. The pre-mix procedure of the TSMA can effectively develop some strength enhancing chemical products including, C(3)S(2)H(3), ettringite, CH and C(6)S(3)H, which shows that RAC made from the TSMA can improve the hydration processes.


Assuntos
Fenômenos Químicos , Conservação dos Recursos Naturais , Materiais de Construção , Resíduos Industriais , Minerais/química , Eliminação de Resíduos/métodos
13.
Int J Tuberc Lung Dis ; 10(10): 1080-90, 2006 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-17044199

RESUMO

SETTING: Six trials from Haiti, Mexico, the U.S.A., Brazil, Spain, Zambia and Hong Kong. OBJECTIVE: To evaluate the efficacy and safety of rifampicin plus pyrazinamide (RZ) vs. isoniazid (INH) for the prevention of tuberculosis (TB) among persons with or without human immunodeficiency virus (HIV) infection. DESIGN: Meta-analysis of randomised controlled trials (RCTs) and quasi-RCTs that compared RZ for 2-3 months with INH for 6-12 months. Endpoints were development of active TB, severe adverse effects and death. Treatment effects were summarised as risk difference (RD) with 95% confidence intervals (CI). RESULTS: Three trials conducted in HIV-infected patients and three trials conducted in non-HIV-infected persons were identified. The rates of TB in the RZ group were similar to those in the INH group, whether the subjects were HIV-infected or not (HIV-infected patients: pooled RD = 0%, 95% CI -1-2, P = 0.89; non-HIV-infected persons: pooled RD = 0%, 95% CI -2-1, P = 0.55). There was no difference in mortality between the two treatment groups (HIV-infected patients: pooled RD = -1%, 95% CI -4-2, P = 0.53; non-HIV-infected persons: pooled RD = 0%, 95% CI -1-1, P = 1.00). However, both subgroup analyses showed that a higher incidence of all severe adverse events was associated with 2RZ than INH among non-HIV-infected persons (RD = 29%, 95% CI 13-46, P = 0.0005 vs. RD = 7%, 95% CI 4-10, P < 0.0001). CONCLUSION: RZ is equivalent to INH in terms of efficacy and mortality in the treatment of latent tuberculosis infection. However, this regimen increases the risk of severe adverse effects compared with INH in non-HIV-infected persons.


Assuntos
Antibióticos Antituberculose/uso terapêutico , Antituberculosos/uso terapêutico , Isoniazida/uso terapêutico , Pirazinamida/uso terapêutico , Rifampina/uso terapêutico , Tuberculose/prevenção & controle , Antibióticos Antituberculose/efeitos adversos , Antituberculosos/efeitos adversos , Comorbidade , Quimioterapia Combinada , Infecções por HIV/epidemiologia , Humanos , Isoniazida/efeitos adversos , Fígado/efeitos dos fármacos , Pirazinamida/efeitos adversos , Ensaios Clínicos Controlados Aleatórios como Assunto , Rifampina/efeitos adversos , Medição de Risco , Tuberculose/tratamento farmacológico , Tuberculose/epidemiologia
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