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1.
Drugs Today (Barc) ; 57(11): 653-663, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34821879

RESUMO

Multiple myeloma is the second most common hematologic malignancy worldwide. Despite the growing number of available therapeutic options and advances in the treatment since the 2000s, relapse of multiple myeloma is inevitable. Currently, the main therapeutic agents for multiple myeloma treatment include proteasome inhibitors, immunomodulatory drugs, monoclonal antibodies and others. Patients who relapse or are refractory to the above-mentioned treatments have poor prognosis. B-cell maturation antigen (BCMA) is a cell-surface receptor which is expressed on the membrane of multiple myeloma cells, but absent on naive and memory B cells, making it an ideal target for multiple myeloma treatment. Belantamab mafodotin (GSK-2857916) is a first-in-class BCMA antibody-drug conjugate with an overall response rate of 32% in the phase II clinical trial DREAMM-2, which is a phase II study designed to investigate the efficacy and safety of belantamab mafodotin in relapsed/refractory patients with multiple myeloma. In August 2020, based on the results of this pivotal DREAMM-2 study, the U.S. Food and Drug Administration (FDA) approved belantamab mafodotin as a monotherapy for relapsed/refractory multiple myeloma. Thereafter, the European Medicines Agency (EMA) also approved this indication. Although belantamab mafodotin has demonstrated single-agent activity in relapsed/refractory multiple myeloma, further studies to evaluate its efficacy and its combinational use with other drugs are necessary and ongoing.


Assuntos
Imunoconjugados , Mieloma Múltiplo , Anticorpos Monoclonais Humanizados , Humanos , Mieloma Múltiplo/tratamento farmacológico , Recidiva Local de Neoplasia
2.
Zhonghua Yi Xue Za Zhi ; 101(44): 3643-3649, 2021 Nov 30.
Artigo em Chinês | MEDLINE | ID: mdl-34823281

RESUMO

Objective: To understand gender differences of cardiovascular risk factors in patients with acute myocardial infarction (AMI) in China. Methods: A total of 26 592 patients with AMI from 107 hospitals in 31 provinces in China from January 1, 2013 to September 30, 2014 were included. Self-designed questionnaire was used to collect patients' age, gender, height, weight, type of AMI, medical history of cardiovascular and cerebrovascular diseases, medication history, lifestyle and AMI risk factors, including high blood pressure, diabetes, dyslipidemia, overweight and/or obesity, smoking history and family history of early onset coronary artery disease. A total of 24 394 patients with complete clinical data were included in the analysis, and gender differences in cardiovascular risk factors were analyzed in all and subgroups with different characteristics. Results: The patients were (62.2±13.8) years old, including 18 162 (74.5%) males and 18 209 (74.6%) ST-segment elevation myocardial infarction (STEMI). The age of male patients was (60.2±13.7) years, which was younger than that of female patients [(68.2±12.3) years]. The body mass index of male patients was (24.2±3.0) kg/m2, which was higher than that of female patients [(23.8±3.4) kg/m2]. The proportions of patients with overweight and/or obesity, smoking history, dyslipidemia, family history of early onset coronary heart disease, fatty diet and history of AMI were 51.8%, 55.2%, 7.2%, 3.8%, 80.4% and 7.7%, which were higher than those of females (45.9%, 9.9%, 5.8%, 2.3%, 65.0% and 5.9%, respectively]. The proportions of hypertension, diabetes, physical inactivity and stroke history were 46.5%, 17.2%, 77.8% and 8.5%, respectively, which were lower than those in female patients [61.4% (3 829 cases), 24.8%, 81.7% and 11.1%, respectively] (all P values<0.05).The proportions of peripheral vascular diseases history in male and female patients were 0.6% and 0.7%, respectively, with no statistical significance in difference (P>0.05). Subgroup analysis showed inconsistent results comparing to analysis of all patients: there were no statistical significance in gender differences as for the proportion of dyslipidemia in the non-ST-segment elevation MI group, the proportion of family history of early onset coronary heart disease in the young and middle aged groups, the proportion of overweight and/or obesity, and the proportion of physical inactivity in the elderly group (all P values>0.05). Conclusions: There are gender differences in cardiovascular risk factors among Chinese patients with acute myocardial infarction. Hypertension and diabetes are more common in women, and overweight and/or obesity, fatty diet and smoking are more common in men.


Assuntos
Doenças Cardiovasculares , Infarto do Miocárdio , Idoso , China/epidemiologia , Feminino , Fatores de Risco de Doenças Cardíacas , Humanos , Masculino , Pessoa de Meia-Idade , Infarto do Miocárdio/epidemiologia , Fatores de Risco , Fatores Sexuais
3.
Int J Cardiol ; 2021 Nov 12.
Artigo em Inglês | MEDLINE | ID: mdl-34780886

RESUMO

BACKGROUND: The aim of the study was to compare the real-world effectiveness and safety in atrial fibrillation (AF) patients treated with edoxaban versus other oral anticoagulants (OACs) (apixaban, dabigatran, rivaroxaban, and vitamin K antagonists [VKA]) in Germany. METHODS AND RESULTS: Using a representative database of 3.5 million statutory health-insured lives in Germany, a retrospective cohort study was conducted to examine ischemic stroke (IS) or systemic embolism (SE) and major bleeding in AF patients initiating anticoagulant therapy from January 2014 through June 2017. Inverse probability of treatment weighting using propensity score was applied for baseline covariate adjustment. Cox proportional hazards models were used to estimate the adjusted risk (hazard ratio [HR]) of each outcome comparing edoxaban versus other OACs. Among 21,038 patients treated with OACs, 1236 edoxaban, 6053 apixaban, 1306 dabigatran, 7013 rivaroxaban, and 5430 VKA patients were included. The adjusted combined risks of IS or SE were lower (p < 0.05) for each edoxaban pairwise comparison with other OACs (HR: 0.83 vs. apixaban, 0.60 vs. dabigatran, 0.72 vs. rivaroxaban, 0.64 vs. VKA). Edoxaban favored lower risks of major bleeding compared with rivaroxaban (HR: 0.74) and VKA (HR: 0.47). No differences in the risk of major bleeding were found between edoxaban and apixaban (p = 0.33), and between edoxaban and dabigatran (p = 0.06). CONCLUSIONS: Edoxaban was associated with better effectiveness compared with other OACs in AF patients from Germany. Edoxaban also demonstrated a favorable safety profile.

4.
Zhonghua Liu Xing Bing Xue Za Zhi ; 42(4): 651-655, 2021 Apr 10.
Artigo em Chinês | MEDLINE | ID: mdl-34814445

RESUMO

Objective: This study explored the association between antenatal calcium supplementation in the childbearing aged women and risk of small for gestational age infant (SGA) among singleton in Shaanxi province,China. Methods: Multi-stage random cluster sampling method was employed to collect information about pregnant women, who were pregnant and had definite outcomes, and their infants, from 30 districts (counties) in 2010 to 2013. Information was collected by face-to-face questionnaire survey. Generalized linear mixed models were employed after adjusting covariates. Dependent variable was whether single-birth neonate was SGA, and independent variable was calcium supplementation of childbearing aged women in different pregnant periods. Results: A total of 28 357 childbearing aged women was recruited in this study. The age of these women was (28.08±4.74) years old, of which, 79.28% were rural residents and 60.90% had calcium supplementation intake. There was a number of 12 810 female in singleton neonates. The neonatal birth weight and gestational age were (3.27±0.16) kg and (277.44±8.80) day, respectively. The prevalence of SGA was 11.35% in total, and 10.48% in mothers with maternal calcium supplementation and 12.70% in mothers without maternal calcium supplementation in whole antenatal period. There were statistically significant differences seen in antenatal calcium supplementation within the subgroups of maternal age (whether the mother was an advanced maternal woman), residential area, maternal occupation, maternal parity, maternal education level, and household incomes (P<0.05). After adjusting these covariates, the risk of SGA among childbearing aged women with antenatal calcium supplementation showed 16% decreased risk (OR=0.84, 95%CI: 0.77-0.92). Further analysis of the different antenatal periods showed that calcium supplementation during the second and third trimester had a statistically significant difference in reducing the risk of neonatal SGA (P<0.05). Besides, subgroup analysis showed that there was a statistically significant difference between the perinatal calcium supplementation and the single-born neonates with SGA Significance (P<0.05) in non-advanced women, those who had a low education level and moderate household economic status groups. Conclusion: The risk reduction of SGA among singleton neonates is related to calcium supplementation during antenatal period in Shaanxi province.


Assuntos
Cálcio , Ácido Fólico , Adulto , Idoso , Suplementos Nutricionais , Feminino , Idade Gestacional , Humanos , Recém-Nascido , Recém-Nascido Pequeno para a Idade Gestacional , Gravidez , Adulto Jovem
6.
Zhonghua Xin Xue Guan Bing Za Zhi ; 49(10): 1000-1011, 2021 Oct 24.
Artigo em Chinês | MEDLINE | ID: mdl-34674438

RESUMO

Objective: To analyze the effects of different types of sodium-glucose cotransporter 2 inhibitors (SGLT2i) on 24-hour ambulatory blood pressure in patients with type 2 diabetes mellitus and hypertension. Method: In this meta-analysis, we searched for randomized controlled trials on the effect of SGLT2i on 24-hour ambulatory blood pressure in patients with type 2 diabetes and hypertension. Three databases, namely PubMed, Web of Science and Cochrane Library, were searched. The search was organized on the concept of 3 conceptual groups: the first group contained terms used to describe SGLT2i, the second group contained terms related to blood pressure, and the third group contained terms used to describe randomized controlled trials. The search time was from the establishment of the database to December 2020. The inclusion and exclusion criteria were formulated in accordance with the requirements of the Cochrane systematic review. According to whether the heterogeneity of the study was significant or not, a random effect model or a fixed effect model were used to conduct the analysis on the impact of different types of SGLT2i on 24-hour ambulatory blood pressure and day and night blood pressure in patients with type 2 diabetes and hypertension. Further subgroup analysis was performed to define potential factors, which might lead to clinical heterogeneity. Results: Seven clinical trials were finally included. The result of the meta-analysis showed that compared with placebo group, SGLT2i could reduce the 24-hour dynamic systolic blood pressure of patients with type 2 diabetes and hypertension by 4.36 mmHg (1 mmHg=0.133 kPa). Reduction was 4.59, 3.74, 5.06, and 3.64 mmHg by canagliflozin, dapagliflozin, empagliflozin, and ertugliflozin respectively; SGLT2i could reduce the 24-hour dynamic diastolic blood pressure of patients with type 2 diabetes and hypertension by 2.20 mmHg, and the reduction was 2.30, 1.22, 2.00, and 2.69 mmHg by canagliflozin, dapagliflozin, empagliflozin and ertugliflozin respectively. SGLT2i could reduce the daytime systolic blood pressure of patients with type 2 diabetes and hypertension by 5.25 mmHg, and reduction was 5.38, 4.87, 6.00, and 4.37 mmHg by canagliflozin, dapagliflozin, empagliflozin and ertugliflozin, respectively. Simultaneously, SGLT2i could reduce the diastolic blood pressure of patients with type 2 diabetes and hypertension by 2.62 mmHg, and the reduction was 2.56, 2.47, and 2.80 mmHg by canagliflozin, empagliflozin and ertugliflozin, respectively. SGLT2i could reduce the nighttime systolic blood pressure of patients with type 2 diabetes and hypertension by 3.62 mmHg, and the reduction was 2.09, 2.06, 3.92, and 2.45 mmHg by canagliflozin, dapagliflozin, empagliflozin and ertugliflozin, respectively. At the same time, SGLT2i could reduce the nighttime diastolic blood pressure of patients with type 2 diabetes and hypertension by 1.60 and 1.51 mmHg, the reduction was 1.53 and 2.58 mmHg by canagliflozin, empagliflozin and ertugliflozin, respectively. Conclusion: SGLT2i can reduce 24-hour ambulatory blood pressure in patients with type 2 diabetes and hypertension.


Assuntos
Diabetes Mellitus Tipo 2 , Hipertensão , Inibidores do Transportador 2 de Sódio-Glicose , Pressão Sanguínea , Monitorização Ambulatorial da Pressão Arterial , Diabetes Mellitus Tipo 2/complicações , Diabetes Mellitus Tipo 2/tratamento farmacológico , Humanos , Hipertensão/complicações , Hipertensão/tratamento farmacológico , Inibidores do Transportador 2 de Sódio-Glicose/uso terapêutico
7.
Int J Radiat Oncol Biol Phys ; 111(3S): e244, 2021 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-34701001

RESUMO

PURPOSE/OBJECTIVE(S): Recent studies reported that the ultra-high dose rate (FLASH) irradiation induced less healthy tissue damages compared with conventional dose rate (CONV) irradiation, this phenomenon was referred to as the FLASH effect and the underlying mechanism remains elusive. This work aims to investigate the impact of antioxidants on the FLASH effect. MATERIALS/METHODS: BALB/c nude mice were treated with the antioxidant N-Acetylcysteine (NAC) and received whole abdominal 6 MeV X-ray FLASH (> 150 Gy/s) or CONV (0.2 Gy/s) irradiation. The prescribed doses were 16 Gy (lethal dose) and 10 Gy (non-lethal dose). EBT3 films were used to confirm the dose. Mice were sacrificed 24 h post-irradiation (pi) to study acute tissue responses or followed up to 6 weeks to look at late-stage responses and the survival probability. Whole blood count, cytokine expression, histologic analysis, and TUNEL assay of intestine were used performed. RESULTS: Mice that received FLASH irradiation had a higher survival probability 6 weeks pi, and less acute and late-stage intestine damages compared to CONV irradiation. For mice that received FLASH irradiation, there are no statistically significant differences in whole blood count, survival probability and intestine damages between NAC treated group and the non-NAC treated group. However, for mice who received CONV irradiation, mice treated with NAC had significantly lower survival probability, more white blood cells, lymphocytes, and neutrophils compared to those not treated with NAC. CONCLUSION: 6 MeV X-ray FLASH irradiation can spare healthy tissues compared to CONV irradiation. Administration of antioxidant lead to more radiation induced damages under CONV irradiation but no statistic significant impact on the tissue response to FLASH irradiation. More (ongoing) experiments should be performed to study the role of antioxidants in the FLASH effect.

8.
Int J Radiat Oncol Biol Phys ; 111(3S): e262, 2021 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-34701040

RESUMO

PURPOSE/OBJECTIVE(S): We retrospectively analyzed the oncological outcomes of T3 or G3 distal ureteral urothelial carcinoma (DUUC) underwent partial ureterectomy (PU) followed by adjuvant radiotherapy (ART). MATERIALS/METHODS: From January 2008 to September 2019, clinical data from a total of 221 patients with pathologic T3 or G3 who underwent PU or RNU at our hospital were analyzed. 17 patients of them were treated with PU+ART, 72 with PU alone and 132 with RNU. Clinicopathologic outcomes were evaluated. Survival was assessed using the Kaplan-Meier method. Cox regression addressed recurrence-free survival (RFS), metastasis-free survival (MFS), cancer specific survival (CSS) and overall survival (OS). RESULTS: Median age and follow-up time were 68 (IQR 62-76) years old and 43 (IQR 28-67) months, respectively. In univariate and multivariable analyses, no LNM and ART were independent prognostic factors of RFS (P = 0.031 and 0.016, respectively). ART significantly improved 5-year RFS Compared with the PU alone, (67.6% vs. 39.5%, HR: 2.431, 95% CI 1.210-4.883, P = 0.039). There was no statistical difference in 5-year RFS between PU+ART and RNU groups (67.6% vs. 64.4%, HR = 1.113, 95% CI 0.457-2.712, P = 0.821). Compared with PU alone or RNU, PU+ART demonstrated no statistical difference in 5-year MFS (PU+ART 73.2%, PU 57.2%, RNU69.4%), CSS (70.7%, 55.1%, 76.6%, respectively), and OS (70.7%, 54.1%, 69.2%, respectively). CONCLUSION: For distal ureteral urothelial carcinoma patients with T3 or G3, adjuvant radiotherapy could significantly improve recurrence-free survival compared with partial ureterectomy alone. There was no significant difference between survival outcomes of PU+ART and radical nephroureterectomy.

9.
Int J Radiat Oncol Biol Phys ; 111(3S): e291, 2021 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-34701107

RESUMO

PURPOSE/OBJECTIVE(S): The aim of this study was to evaluate the survival in synchronous oligometastatic prostate cancer patients treated with radiotherapy (RT) for both primary tumor and all metastatic lesions. MATERIALS/METHODS: This was a single-center cohort study. Synchronous oligometastatic (≤5) prostate cancer patients with RT for both primary tumor and all metastatic lesions were included. Kaplan-Meier method, log rank test and cox regression were used to calculate OS and PFS. PFS included PSA failure, local or distant failure assessed by imaging. RESULTS: This study analyzed 60 patients from 10/2011 to 12/2017 with median follow-up of 48 months. All patients had metastatic disease at the time of initial diagnosis and all patients received androgen deprivation therapy (ADT). Forty-four (73%) patients were hormone sensitive (HSPC) and 16 (27%) patients were castrate resistant (CRPC) at the time of RT. PSMA PET/CT was used for 7 (12%) men. The most common fractionation schemes of the primary tumor were 2 Gy for 35-38 fractions (67%) and 2.7-2.8 Gy for 13 fractions (22%). The median BED3 was 126 Gy (range, 100-128 Gy). A total of 37 (62%) patients were treated with whole pelvic RT (WPRT). A total of 87 metastatic lesions were treated with RT. The median BED3 was 120 Gy for metastatic lesions (range, 63-139 Gy). For the whole cohort, the PFS and OS were 51.4% and 47.4% at 4 years. Median PFS for men with HSPC was 78 months compared with 11 months in men with CRPC. Median OS for men was 45 months in men with CRPC. On univariable analysis, HSPC, shorter interval between diagnosis and RT, lower pre-RT PSA, lower Gleason score, lower metastatic burden/volume, use of WPRT were associated with improved PFS. CONCLUSION: Our study suggests that RT for the primary tumor and all metastatic lesions plus systemic therapy has better survival than clinical studies of prostate radiotherapy alone, especially for patients with HSPC, shorter interval between diagnosis and RT and lower metastatic burden/volume.

10.
Int J Radiat Oncol Biol Phys ; 111(3S): e291, 2021 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-34701108

RESUMO

PURPOSE/OBJECTIVE(S): To assess the toxicity profile and biochemical control of a moderately hypo-fractionated radiotherapy (RT) to the prostatic bed after prostatectomy. MATERIALS/METHODS: From Sep. 2017 to Nov. 2020, 215 Patients with prostate adenocarcinoma who were recommended to receive adjuvant or salvage RT were prescribed to moderately hypo-fractionated RT (62.75 Gy delivered in 2.51 Gy per fractions) to prostatic bed. Whole-pelvis irradiation was performed in 93.0% of patients. Concurrent hormone therapy was administrated in 97.2% of patients. All patients received IMRT with daily image-guided radiotherapy (IGRT). Acute and late toxicity was recorded and graded according to CTCAE 4.0. RESULTS: The median follow-up was 22 months (range, 1-46 months). Acute grade 2 GI and GU toxicities were 9.3% (20/215) and 11.6% (25/215) respectively. Late grade 2 GI and GU toxicity were 3.7% (8/215) and 16.3% (35/215). No patients complained of acute and late grade ≥3 GI, GU toxicities. The actuarial three-year estimated biochemical progression-free survival (b-PFS) was 89.6% for the entire population. CONCLUSION: After prostatectomy, moderately hypo-fractionated RT (2.51 Gy/f25 f) demonstrated promising early biochemical control and acceptable toxicity profile. Prospective randomized trials are warranted with longer follow-up in larger cohorts to confirm these findings.

11.
Int J Radiat Oncol Biol Phys ; 111(3S): e541-e542, 2021 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-34701703

RESUMO

PURPOSE/OBJECTIVE(S): This article will investigate the appropriate image-guidance (IG) strategy for spine metastases (SpM) radiotherapy by analyzing the delivered dose under different IG strategies with setup errors from daily cone-beam computed tomography (CBCT). MATERIALS/METHODS: A total of 720 CBCT scans about 36 vertebrae lesions from 2017 to 2019 were enrolled. All lesions were divided into two groups, twenty for simultaneous boost (PTV 40 Gy/20f, GTV 60 Gy/20f) and sixteen for conventional fractionated (PTV 40 Gy/20f). The actual fractionated plan was recalculated after transferring the isocenter of the original plan according to the inter-fraction setup error. Then under no daily image-guidance (no-DIG) strategies, like twice imaging guidance weekly (TIG), initial 5 days then weekly imaging guidance (5D+WIG), weekly imaging guidance (WIG) and no imaging guidance (NIG), the dose deviation was calculated between the delivered dose accumulated by each actual fractionated plan and the original RT-plan which is regarded as the dose distribution under daily image guidance (DIG). The tolerance of dose deviation for the target is within ± 5% and the Dmax of the spinal cord is limited below 45 Gy. RESULTS: When conventional fractionated radiotherapy, under strategies of image-guidance like TIG, 5D+WIG, WIG and NIG, the median dose deviations are 0% (-1.0% ∼ 1.2%), 0.2% (-0.8% ∼ 1.2%), 0.4% (-0.6% ∼ 1.8%), 0.8% (-0.2% ∼ 2.4%) for the Dmax of spinal cord; -0.2% (-1.4% ∼ 0%), -0.4% (-1.4% ∼ 0%), -0.8% (-2.3% ∼ -0.4%), -1.6% (-3.2% ∼ -0.8%) for the CTV D95; -6.0% (-8.4% ∼ -4.6%), -5.9% (-8.3% ∼ -4.6%), -8.0% (-11.3% ∼ -6.4%), -10.8% (-14.4% ∼ -8.7%) for the PTV D95. When simultaneous boosting, the median dose deviations correspondingly are 9.5% (7.2% ∼ 12.4%), 9.3% (7.0% ∼ 11.9%), 11.2% (9.3% ∼ 16.4%), 14.2% (11.6% ∼ 20.2%) and the proportions of case whose maximum irradiated dose of spinal cord is more than 45 Gy are all beyond 70% for the Dmax of spinal cord; -5.1% (-7.9% ∼ -4.2%), -4.7% (-7.4% ∼ -4.2%), -7.0% (-10.3% ∼ -6.0%), -8.6% (-13.1% ∼ -7.3%) for the GTV D95; -3.5% (-7.3% ∼ -2.1%), -3.4% (-6.8% ∼ -1.7%), -6.2% (-11.1% ∼ -3.9%), -9.0% (-16.5% ∼ -5.6%) for the PTV D95. CONCLUSION: When conventional fractionated radiotherapy, the image-guidance strategies could be chosen according to the clinical practice. However, it is necessary to do daily IGRT for spine metastases radiotherapy when simultaneous boosting because the dose deviations for the Dmax of spinal cord, GTV D95 are all out of the tolerance. AUTHOR DISCLOSURE: C.Jia: None. B. Zhao: None. X. Gao: None. Y. Bai: None. Z. Shang: None.

12.
Zhonghua Yu Fang Yi Xue Za Zhi ; 55(10): 1209-1213, 2021 Oct 06.
Artigo em Chinês | MEDLINE | ID: mdl-34706506

RESUMO

Objective: To establish the norm of the Chinese version of Karitane Parenting Confidence Scale (KPCS) in urban areas of China. Methods: From August to December 2017, the parents of 2 216 children (<36 months old) were selected from 15 cities (Beijing, Lianyungang, Hangzhou, Chengdu, Xi'an, Guangzhou, Changsha, Jinan, Guiyang, Ningbo, Dalian, Qinhuangdao, Maanshan, Chongqing and Wuhan) in 14 provinces by stratified random sampling. The general demographic characteristics and parents' parenting confidence were collected by a self-made questionnaire and KPCS Chinese version. The percentile norm was established. P3, P10 and P25 were used as the criteria to define the degree of lack of parenting confidence. Results: The age of mothers was (30.67±4.29). The age of the father was (32.50±4.99) years old. There were 726 (32.76%), 759 (34.25%) and 731 (32.99%) infants in 6-12, 12-23 and 24-35 months old groups. The total scores of P50, P25, P10 and P3 of KPCS (Chinese version) of infant parents in urban areas in China were 41, 38, 33, and 29 respectively. When the scores of parents were 34-37, 30-33, and ≤ 29, they were judged as mild, moderate, and severe lack of parenting confidence. There was no significant difference in the Chinese version of KPCS between parents of different age groups and parents of different gender (χ²=3.53, P=0.171; χ²=1.41, P=0.236). Each factor score≤P3 is defined as the boundary score, and the corresponding boundary scores of "parenting" "support" and "competence" were 13, 9, and 5 respectively. Conclusion: The Chinese version of KPCS can be used to assess the parenting confidence of infants in urban areas of China. It can used as one of the bases for scientific and objective evaluation of the parenting status of families.


Assuntos
Mães , Poder Familiar , Adulto , Pequim , Criança , China , Feminino , Humanos , Lactente , Inquéritos e Questionários
13.
Zhonghua Yu Fang Yi Xue Za Zhi ; 55(10): 1240-1244, 2021 Oct 06.
Artigo em Chinês | MEDLINE | ID: mdl-34706511

RESUMO

An epidemiological investigation was carried out on a local cluster of outbreak caused by imported cases of Coronavirus Disease 2019 (COVID-19) in rural areas of Chengdu in December 2020, to find out the source of infection and the chain of transmission. According to Prevention and Control Protocol for COVID-19 (Version 7), field epidemiological investigation was adopted, combined with big data technology, video image investigation, gene sequencing and other methods to carry out investigation into COVID-19 cases and infections source tracing, analyze the epidemiological association, and map the chain of transmission. From December 7 to 17, 2020, 13 local COVID-19 confirmed cases and 1 asymptomatic case were diagnosed in Chengdu, of which 12 cases (85.71%) had a history of residence and activity in the village courtyard of Taiping (TP), Pidu (P) District, Chengdu. From November 8, 2020 to November 28, 2020, a group of inbound people form Nepal were transferred to the designated entry personnel quarantine hotel of P District which was adjacent to the TP village. During quarantine, there were 5 cases who tested positive for COVID-19. Through gene sequencing alignment, genes of local cases and Nepalese imported cases from the same period are homologous, all belong to the lineage of L2.2.3 (B.1.36 according to Pangolin lineage typing method). According to the results of field epidemiological investigation and gene sequencing analysis, the index case was most likely infected by contact with household waste of quarantine site. Under the situation of normalization prevention and control of COVID-19, sentinel monitoring of fever clinics in primary medical institutions is the key to early detection of the epidemic. The multi-department joint epidemiological investigation and the application of gene technology are the core links of the investigation and traceability of modern infectious diseases. The allocation of public health resources in rural areas needs to be strengthened. We need to improve the capacity for early surveillance and early warning of the epidemic in rural areas.


Assuntos
COVID-19 , Epidemias , Surtos de Doenças , Humanos , Quarentena , SARS-CoV-2
14.
Artigo em Inglês | MEDLINE | ID: mdl-34479791

RESUMO

The aim of this study was to evaluate the rare postoperative supraclavicular metastasis originating from oral squamous cell carcinoma (OSCC) and to discuss epidermal growth factor receptor (EGFR) as a potential predictive marker. Tumour specimens of OSCC patients divided into three groups were included: supraclavicular metastasis (n = 8), conventional cervical metastasis (n = 28), no metastasis (n = 48). Basic information and EGFR expression were compared among these groups and the data were analysed to identify potentially related risk factors for supraclavicular metastasis. In the supraclavicular metastasis group (n = 8), all primary tumours were T1-T2 and located in the tongue and buccal region; five of eight cases were pathologically N0. The median interval from the primary tumour resection to the development of supraclavicular metastases was 21.5 months. All related deaths (5/8) occurred within 2 years. In the supraclavicular metastasis group, EGFR expression was highest in the supraclavicular metastases, followed by cervical lymph nodes, and was lowest in the primary tumours (P = 0.39). In contrast, in the conventional metastasis group and the N0 group, EGFR expression was higher in the primary tumours than in the lymph nodes (P < 0.01). Supraclavicular metastasis of OSCC is infrequent and associated with a poor prognosis. EGFR might predict the occurrence of supraclavicular metastasis.

15.
Plant Biol (Stuttg) ; 2021 Sep 07.
Artigo em Inglês | MEDLINE | ID: mdl-34490731

RESUMO

Most species in the genus Cypripedium (Cypripedioideae) produce trap flowers, making it a model lineage to study deceptive pollination. Floral attractants in most species studied appear to target bee species of different sizes. However, more recent publications report fly pollination in some subalpine species, suggesting novel suites of adaptive floral traits. Cypripedium lichiangense (section Trigonopedia) is an endangered subalpine species endemic to the Hengduan Mountains, China. We observed and analysed its floral traits, pollinators and breeding systems over 2 years in situ and in the lab. Cypripedium lichiangense was visited by females of Ferdinandea cuprea (Syrphidae). The pollinia were carried dorsally on the fly thoraces. The eggs of this fly were frequently found in the saccate labellum and on other floral organs, suggesting brood-site mimesis. The orchid is self-compatible, but cross-pollination produces more viable embryos. We propose a new mode of floral mimesis, humus-rich oviposition site mimicry, for C. lichiangense. Compared with the mimesis of aphid colonies attracting syrphid pollinators (subfamily Syrphinae), whose larvae are entomophagic, as reported in some Paphiopedilum species (Cypripedioideae), pollination by deceit in C. lichiangense represents a distinct and separate mode of exploitation of another saprophagic (or phytophagic) larvae syrphid lineage in the subfamily Eristalinae and appears to indicate diversity of pollination strategies in Section Trigonopedia of Cypripedium. However, this new brood-site mimesis seems to be less attractive to pollinators. As a possible adaptation to the weak attracted pollination strategy, this plant species has a long flowering period and extended lifespan of individual flowers to ensure reproductive success.

17.
Zhonghua Kou Qiang Yi Xue Za Zhi ; 56(9): 829-832, 2021 Sep 09.
Artigo em Chinês | MEDLINE | ID: mdl-34496529

RESUMO

Regarding the illegal performance of "tooth beauty" and the mal-practice in aesthetic dentistry, the author proposed boycotts and solutions that were making clear of the property and forming professional guidelines, getting supports from administrations by fully communication, enhancing oral health education, promoting self-discipline within professions, and standing firmly on medical profession morals.


Assuntos
Beleza , Estética Dentária
20.
J Dent Res ; : 220345211036663, 2021 Sep 13.
Artigo em Inglês | MEDLINE | ID: mdl-34515552

RESUMO

Early childhood caries is common in Hong Kong, and parental practices on maintaining good oral health of their young children are far from satisfactory. This article reports on the effectiveness of a randomized controlled trial on family-centered oral health promotion to new parents in establishing proper feeding habits and oral hygiene practices and in reducing caries risk among 3-y-old toddlers. At baseline, pregnant mothers and their husbands were recruited and randomly allocated into 2 groups. The test group received individualized oral health education (OHE) via a behavioral and educational counseling approach while the control group received the OHE pamphlets only. Information related to the feeding habits, oral hygiene practices, and oral health of the toddlers was collected by parent-completed questionnaires and oral examination annually via home visits. A total of 580 families were recruited at baseline, and 436 toddlers were followed up when they reached 3 y old (test, n = 228; control, n = 208; follow-up rate, 75.2%). The proportions of toddlers who held food in the mouth, fell asleep when milk feeding, had prolonged use of the nursing bottle, ate before bed, and consumed a sweet snack daily were significantly lower in the test group than in the control group (all P < 0.05). Significantly higher proportions of toddlers brushed their own teeth twice daily, were brushed by their parents twice daily, and used fluoride toothpaste than in the control group (all P < 0.001). Toddlers in the test group had better oral health status with a lower level of visible plaque, Streptococcus mutans, white spot lesion, and cavitated lesion (all P < 0.05). Family-centered oral health promotion and individualized OHE for parents via a behavioral and educational counseling approach are more effective in establishing good feeding habits and parental toothbrushing practices and in decreasing the caries risk of their toddlers than the distribution of OHE pamphlets alone (ClinicalTrials.gov NCT02937194).

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