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1.
J Am Chem Soc ; 2020 Feb 07.
Artigo em Inglês | MEDLINE | ID: mdl-32031790

RESUMO

State-of-the-art, high-performance perovskite solar cells (PSCs) contain a large amount of iodine to realize smaller bandgaps. However, the presence of numerous iodine vacancies at the surface of the film formed by their evaporation during the thermal annealing process has been broadly shown to induce deep-level defects, incur non-radiative charge recombination and induce photocurrent hysteresis, all of which limit the efficiency and stability of PSCs. In this work, modifying the defective surface of perovskite films with cadmium iodide (CdI2) effectively reduces the degree of surface iodine deficiency, and stabilizes iodine ions via the formation of strong Cd-I ionic bonds. This largely reduces the interfacial charge recombination loss, yielding a high efficiency of 21.9% for blade-coated PSCs with an open-circuit voltage of 1.20 V, corresponding to a record small voltage deficit of 0.31 V. The CdI2 surface treatment also improves the operational stability of the PSCs, retaining 92% efficiency after constant illumination at 1 sun intensity for 1000 h. This work provides a promising strategy to optimize the surface/interface optoelectronic properties of perovskites for more efficient and stable solar cells and other optoelectronic devices.

2.
Sci Total Environ ; 707: 135587, 2020 Mar 10.
Artigo em Inglês | MEDLINE | ID: mdl-31784147

RESUMO

Mulch drip irrigation is widely used in the arid areas of Northwest China. Consequently, the Manas River Basin has developed into the fourth largest irrigated agricultural area in China. In this study, a groundwater model of the regional water cycle was developed to quantitatively assess the groundwater balance in response to different irrigation schemes, including traditional irrigation, conventional water-saving irrigation, and high-efficiency water-saving irrigation schemes. Our results reveal that 1) The water-saving irrigation technology has affected the water cycle process in farmlands. The higher the degree of water conservation, the lower the infiltration into groundwater, the higher the deficit of the groundwater balance, and the more significant the decline of the groundwater level. 2) The groundwater at the Manas River Basin remains in a negative equilibrium state. To achieve an equilibrium state of the groundwater at the Manas River Basin, the catchment management agencies should restrict the scale of oasis development and the utilization of groundwater.

3.
ACS Appl Mater Interfaces ; 12(1): 989-996, 2020 Jan 08.
Artigo em Inglês | MEDLINE | ID: mdl-31818105

RESUMO

The direct band gap CsPbBr3 perovskite is regarded as a promising alternative for low-cost and high-performance X-ray radiation detectors. Despite the fact that CsPbBr3 nanocrystals have been shown to be good scintillators in the indirect conversion mode, the direct X-ray conversion with CsPbBr3 single crystals is expected to yield higher spatial resolution. Here, rubidium (Rb) doping is demonstrated to be an efficient approach to improve carrier transport and X-ray detection performance in the direct-conversion X-ray detectors based on Cs(1-x)RbxPbBr3 single crystals. Electrical properties' characterizations as combined with X-ray photoelectron spectroscopy (XPS) measurements have revealed that Rb doping in Cs(1-x)RbxPbBr3 single crystals can enhance the atomic interaction and orbital coupling between Pb and Br atoms, leading to an enhancement of carrier transport and X-ray detection performance. X-ray detectors based on a small amount (0.037%) of Rb-doped Cs(1-x)RbxPbBr3 single crystals exhibited a high X-ray sensitivity of 8097 µC Gyair-1 cm-2. This work offers a feasible strategy to improve the X-ray detection performance by chemical doping in all-inorganic perovskite X-ray detectors.

4.
Cell Signal ; 66: 109444, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31629025

RESUMO

Laryngeal cancer is one of the most malignant cancers among the head and neck malignant tumors. Abnormal expression of microRNAs (miRNAs) contributes to cancer development through regulating proliferation and apoptosis of cancer cells. In this study, we aim to explore the roles of microRNA-141 (miR-141), Homeobox C6 (HOXC6) and TGF-ß signaling pathway in epithelial-mesenchymal transition (EMT) and lymph node metastasis in laryngeal cancer. Initially, we identified differentially expressed genes in laryngeal cancer, among which HOXC6 was identified. Then the target miRNA of HOXC6 was predicted and verified. Next, expression of miR-141, HOXC6, TGF-ß1, Smad3, Vimentin and Snail in cancer tissues was detected. Then, AMC-HN-8 cells were transfected with miR-141 mimic, miR-141 inhibitor and HOXC6-siRNA to investigate specific role of miR-141, HOXC6 and TGF-ß signaling pathway in laryngeal cancer in vivo and in vitro. Our results showed that HOXC6 was a target gene of miR-141, which was downregulated in laryngeal cancer. Besides, overexpression of miR-141 could downregulate HOXC6 and inhibit the TGF-ß signaling pathway. Upregulation of miR-141 or silencing of HOXC6 can repress EMT, viability, migration and invasion abilities of laryngeal cancer cells. In addition, upregulation of miR-141 inhibited the tumor growth and lymph node metastasis in vivo. In summary, our findings demonstrated that upregulated miR-141 decreased HOXC6 expression, and inhibited the TGF-ß signaling pathway, EMT and lymph node metastasis in laryngeal cancer, which is of clinical significance in the treatment of laryngeal cancer.

5.
ACS Appl Mater Interfaces ; 12(2): 3127-3133, 2020 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-31833753

RESUMO

Two-dimensional (2D) lead halide perovskite has recently been recognized as a promising candidate to stabilize perovskite solar cells due to its extraordinary moisture resistance. These 2D perovskite films often consist of multiple phases with layered (n) lead halide (from n = 1, 2, 3 to ≈∞). However, a convincing evidence is still lacking to clarify the phase distribution with respect to different n, thus causes the misleading for device design. Herein, confocal photoluminescence (PL) spectroscopy was applied to probe the inhomogeneity of 2D perovskite films along the vertical direction to construct a clear-phase distribution mapping consequently. It reveals that the 2D perovskite phases (n = 2, 3, 4) locate preferentially near the substrate, while large n phases are predominantly near the top surface. Moreover, we successfully developed a simple method to manipulate the phase distribution in 2D perovskite thin films, which results in a dramatic increase of device efficiency from 4.95 to 11.6%. Our findings thus provide insights to the understanding of 2D perovskite film growth. The utilization of visualized phase distribution data could also guide the further development of 2D perovskite materials for optoelectronic devices.

6.
Adv Mater ; : e1906171, 2019 Dec 12.
Artigo em Inglês | MEDLINE | ID: mdl-31833134

RESUMO

Pain-perceptual nociceptors (PPN) are essential sensory neurons that recognize harmful stimuli and can empower the human body to react appropriately and perceive precisely unusual or dangerous conditions in the real world. Furthermore, the sensitization-regulated nociceptors (SRN) can greatly assist pain-sensitive human to reduce pain sensation by normalizing hyperexcitable central neural activity. Therefore, the implementation of PPNs and SRNs in hardware using emerging nanoscale devices can greatly improve the efficiency of bionic medical machines by giving them different sensitivities to external stimuli according to different purposes. However, current most-normal organic/oxide transistors face a great challenge due to channel scaling, especially in the sub-10 nm channel technology. Here, a sub-10 nm indium-tin-oxide transistor with an ultrashort vertical channel as low as ≈3 nm, using sodium alginate bio-polymer electrolyte as gate dielectric, is demonstrated. This device can emulate important characteristics of PPN such as pain threshold, memory of prior injury, and pain sensitization/desensitization. Furthermore, the most intriguing character of SRN can be achieved by tuning the channel thickness. The proposed device can open new avenues for the fascinating applications of next-generation neuromorphic brain-like systems, such as bio-inspired electronic skins and humanoid robots.

7.
Proc Natl Acad Sci U S A ; 116(35): 17201-17206, 2019 Aug 27.
Artigo em Inglês | MEDLINE | ID: mdl-31405969

RESUMO

Tropical rainfall variability is closely linked to meridional shifts of the Intertropical Convergence Zone (ITCZ) and zonal movements of the Walker circulation. The characteristics and mechanisms of tropical rainfall variations on centennial to decadal scales are, however, still unclear. Here, we reconstruct a replicated stalagmite-based 2,700-y-long, continuous record of rainfall for the deeply convective northern central Indo-Pacific (NCIP) region. Our record reveals decreasing rainfall in the NCIP over the past 2,700 y, similar to other records from the northern tropics. Notable centennial- to decadal-scale dry climate episodes occurred in both the NCIP and the southern central Indo-Pacific (SCIP) during the 20th century [Current Warm Period (CWP)] and the Medieval Warm Period (MWP), resembling enhanced El Niño-like conditions. Further, we developed a 2,000-y-long ITCZ shift index record that supports an overall southward ITCZ shift in the central Indo-Pacific and indicates southward mean ITCZ positions during the early MWP and the CWP. As a result, the drying trend since the 20th century in the northern tropics is similar to that observed during the past warm period, suggesting that a possible anthropogenic forcing of rainfall remains indistinguishable from natural variability.

8.
Science ; 365(6452): 473-478, 2019 08 02.
Artigo em Inglês | MEDLINE | ID: mdl-31371610

RESUMO

We show that converting the surfaces of lead halide perovskite to water-insoluble lead (II) oxysalt through reaction with sulfate or phosphate ions can effectively stabilize the perovskite surface and bulk material. These capping lead oxysalt thin layers enhance the water resistance of the perovskite films by forming strong chemical bonds. The wide-bandgap lead oxysalt layers also reduce the defect density on the perovskite surfaces by passivating undercoordinated surface lead centers, which are defect-nucleating sites. Formation of the lead oxysalt layer increases the carrier recombination lifetime and boosts the efficiency of the solar cells to 21.1%. Encapsulated devices stabilized by the lead oxysalt layers maintain 96.8% of their initial efficiency after operation at maximum power point under simulated air mass (AM) 1.5 G irradiation for 1200 hours at 65°C.

9.
J Phys Chem Lett ; 10(15): 4203-4208, 2019 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-31291727

RESUMO

van der Waals (vdW) epitaxy offers a promising strategy without lattice and processing constraints to prepare atomically clean and electronically sharp interfaces for fundamental studies and electronic device demonstrations. Herein, PbI2 was thermally deposited at high-vacuum conditions onto CVD-grown monolayer MoS2 flakes in a vdW epitaxial manner to form 3D-2D heterojunctions, which are promising for vdW epitaxial growth of perovskite films. X-ray diffraction, X-ray photoemission spectroscopy, Raman, and atomic force microscopy measurements reveal the structural properties of the high-quality heterojunctions. Photoluminescence (PL) measurements reveal that the PL emissions from the bottom MoS2 flakes are greatly quenched compared to their as-grown counterparts, which can be ascribed to the band alignment-induced distinct interfacial charge-transfer behaviors. Strong interlayer excitons can be detected at the PbI2/MoS2 interface, indicating an effective type II band alignment, which can be further confirmed by ultraviolet photoemission spectroscopy measurements. The results provide a new material platform for the application of the vdW heterojunctions in electronic and optoelectronic devices.

10.
Nanoscale ; 11(28): 13469-13476, 2019 Jul 28.
Artigo em Inglês | MEDLINE | ID: mdl-31287485

RESUMO

The realization of p-n homojunctions, which can be achieved via spatially controlled carrier-type modulation, remains a challenge for two-dimensional transition metal dichalcogenides. Here, we report an effective method to tune intrinsic n-type few-layer MoSe2 to p-type through controlling precisely the ultraviolet-ozone treatment time, which can be attributed to the surface charge transfer from the underlying MoSe2 to MoOx (x < 3). The resulting hole mobility and concentration are ∼20.1 cm2 V-1 s-1 and ∼1.9 × 1012 cm-2, respectively, and the on-off ratio is ∼105, which are comparable to the values of pristine n-type MoSe2. Moreover, the lateral p-n homojunction prepared by partially treating MoSe2 displays a high rectification ratio of 2.4 × 104, an ideality factor of 1.1, and a high photoresponsivity of 0.23 A W-1 to the 633 nm laser at Vd = 0 V and Vg = 0 V due to the built-in potential in the p-n homojunction area. Our findings ensure the MoSe2 p-n diode as a promising candidate for future low-power operating photodevices.

11.
J Phys Condens Matter ; 31(29): 295702, 2019 Jul 24.
Artigo em Inglês | MEDLINE | ID: mdl-30959497

RESUMO

Negative Poisson's ratio (NPR) materials have attracted tremendous interest due to their unusual physical properties and potential applications. Certain two-dimensional (2D) monolayer materials have also been found to exhibit NPR and the corresponding deformation mechanism varies. In this study, we found, based on first-principles calculations, that the Poisson's ratio (PR) sign of monolayer blue phosphorus oxide (BPO) can be tuned by strain: the PR is positive under uniaxial strain [Formula: see text] but becomes negative under [Formula: see text] > 0. The deformation mechanism for BPO under strain depends on the mutual competition between the P-P attraction and P-O repulsion effect, and these two factors induce two different deformation pathways (one with positive PR, and the other with NPR). Moreover, with increasing of strain, both the decreased strength of P-P attraction and the increased strength of P-O repulsion effect modulates the PR of BPO from positive to negative.

12.
J Contam Hydrol ; 223: 103475, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31029465

RESUMO

Selection of proper surfactants is critical for applying surfactant-enhanced remediation (SER) to sites contaminated with nonaqueous phase liquids (NAPLs). Here, ethoxylated nonionic surfactants (Tween 20, Tween 40, Tween 80, and Triton X-100) were evaluated for their applicability to remedy chlorinated organic phases, chloroform (CF), trichloroethylene (TCE), and tetrachloroethylene (PCE), on the basis of solubilization capacity, partitioning behavior, and macroemulsion formation. The most hydrophilic CF was not relevant for SER applications since excessive surfactant partitioning into CF rendered only few of them available for its solubilization. In contrast, the more hydrophobic TCE and PCE, having moderate surfactant partitioning, were effectively solubilized. Among Tween surfactants, a more hydrophobic surfactant showed a larger solubilization potential for both chloroethylenes, but it suffered from a greater partitioning loss. Depending on the type and extent of NAPL contaminations, thus, a prior consideration should be given to either solubilization capacity or partitioning loss when selecting the optimal Tween surfactant. Compared to Tween surfactants, the more hydrophobic Triton X-100 showed greater partitioning losses into all three NAPLs. Of particular, its partitioning into CF and TCE was nearly complete, making impractical its application to the remediation of both organic liquids. The formation of macroemulsions, characterized by a high turbidity, may significantly deteriorate SER applicability by producing undesirable flows in aquifers. Their formation became more problematic with the increasing surfactant hydrophilicity and the increasing NAPL hydrophobicity. When these combinations are applied, it is critical to keep such surfactant concentrations as to exploit the solubilization potential but not to cause the macroemulsion formation.


Assuntos
Tetracloroetileno , Tricloroetileno , Interações Hidrofóbicas e Hidrofílicas , Solubilidade , Tensoativos
13.
Zhongguo Gu Shang ; 32(4): 346-349, 2019 Apr 25.
Artigo em Chinês | MEDLINE | ID: mdl-31027411

RESUMO

OBJECTIVE: To evaluate clinical effect of autologous osteochondral transplantation in treating localized knee cartilage defects. METHODS: Fifteen patients with knee cartilage defects were treated by autologous osteochondral transplantation from January 2007 to January 2008, including 8 females and 7 males, aged from 23 to 45 years old. Preoperative and postoperative KSS score at 10 years were compared. RESULTS: All patients were followed up for 10.0 to 10.7 years, with an average of(10.2±0.3) years. Clinical score of KSS was improved from 38.86±4.09 to 85.07±2.19 at 10 years after operation(P<0.05), functional score increased from 3.33±4.88 to 82.67±4.58 at 10 years after operation(P<0.05), KSS score was improved form 42.20±7.84 befor operation to 167.73±6.29 at 10 years after operation, and had statistical differences before and after operation. While there was no statistical difference in stability of knee joint(P>0.05). All patients had no other complications. CONCLUSIONS: Through long-term follow-up of patients with cartilage defect in knee treated by autologous bone cartilage transplantation showed that this method could effectively improve function of knee joint and alleviate pain. So it is an effective method for repair of osteochondral defect.


Assuntos
Cartilagem Articular , Osteocondrite Dissecante , Adulto , Transplante Ósseo , Feminino , Seguimentos , Humanos , Articulação do Joelho , Masculino , Pessoa de Meia-Idade , Osteocondrite Dissecante/cirurgia , Transplante Autólogo , Adulto Jovem
14.
PLoS One ; 14(4): e0200978, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31017890

RESUMO

1,3-Propanediol (1,3-PDO) is an important compound that is mainly used in industry for polymer production. Fermentation of 1,3-PDO from glycerol by Klebsiella pneumoniae is accompanied by formation of 2,3-butanediol (2,3-BDO) as one of the main byproduct. The first step in the formation of 2,3-BDO from pyruvate is catalyzed by acetolactate synthase (ALS), an enzyme that competes with 1,3-PDO oxidoreductase for the cofactor NADH. This study aimed to analyze the impact of engineering the 2,3-BDO formation pathway via inactivation of ALS on 1,3-PDO fermentation by K. pneumoniae HSL4. An ALS mutant was generated using Red recombinase assisted gene replacement. The ALS specific activities of K. pneumoniae ΔALS were notably lower than that of the wild-type strain. Fed-batch fermentation of the mutant strain resulted in a 1,3-PDO concentration, productivity and conversion of 72.04 g L-1, 2.25 g L-1 h-1, and 0.41 g g-1, increase by 4.71%, 4.65% and 1.99% compared with the parent strain. Moreover, inactivation of ALS decreased meso-2,3-BDO formation to trace amounts, significantly increased 2S,3S-BDO and lactate production, and a pronounced redistribution of intracellular metabolic flux was apparent.


Assuntos
Acetolactato Sintase/metabolismo , Proteínas de Bactérias/metabolismo , Klebsiella pneumoniae/enzimologia , Engenharia Metabólica , Propilenoglicóis/metabolismo , Acetolactato Sintase/genética , Proteínas de Bactérias/genética , Butileno Glicóis/metabolismo , Klebsiella pneumoniae/genética
15.
Medicine (Baltimore) ; 98(6): e14486, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30732220

RESUMO

Serum albumin (SA) is associated with inflammation and thrombosis, which are involved in acute aortic dissection (AAD). Our aim was to investigate the effect of SA level on survival in patients with AAD.We analyzed 777 patients with AAD. The patients were divided into hypoalbuminemia and non-hypoalbuminemia groups according to their AAD Stanford classification. Multivariable Cox regression was used to investigate the association between SA levels and in-hospital mortality in type A and B AAD.A total of 103 (13.3%) patients died in-hospital. The in-hospital mortality in type A and B patients with hypoalbuminemia was higher compared to those without (type A: 34.2% vs 13.9%, P <.001; type B: 7.9% vs 1.6%, P = .001). Kaplan-Meier analysis showed that survival was significantly lower in patients with hypoalbuminemia compared to those without, regardless of AAD type (type A: log-rank χ = 14.71; P <.001; Type B: log-rank χ = 10.42; P = .001). After adjusting for confounding factors, hypoalbuminemia was an independent predictor of in-hospital mortality in patients with either type A (HR, 2.492; 95% confidence interval [CI], 1.247-4.979; P = .010) or type B (HR, 8.729; 95% CI, 1.825-41.736; P = .007).SA is independently associated with increased in-hospital mortality in both type A and B AAD.


Assuntos
Aneurisma Dissecante/sangue , Aneurisma Dissecante/mortalidade , Albumina Sérica/análise , Adulto , Idoso , Aneurisma Dissecante/epidemiologia , Biomarcadores , Feminino , Mortalidade Hospitalar , Humanos , Hipoalbuminemia/epidemiologia , Estimativa de Kaplan-Meier , Masculino , Pessoa de Meia-Idade , Prognóstico , Estudos Retrospectivos , Fatores de Risco
16.
Nanoscale ; 11(3): 1360-1369, 2019 Jan 17.
Artigo em Inglês | MEDLINE | ID: mdl-30604810

RESUMO

The hardware implementation of neuromorphic computing has attracted growing interest as a promising candidate for confronting the bottleneck of traditional von Neumann computers. However, most previous reports are focusd on emulating the synaptic behaviors by a mono-mode using an electric-driving or photo-driving approach, resulting in a big challenge to synchronously handle the natural photoelectric information. Herein, we report a multifunctional photoelectronic hybrid-integrated synaptic device based on the electric-double-layer (EDL) MoS2 phototransistor. Interestingly, the electric MoS2 synapse exhibits a potentiation filtering effect, while the photonic counterpart can implement both potentiation and depression filtering effects. Most importantly, for the first time, photoelectronic and spatio-temporal four-dimensional (4D) hybrid integration was successfully demonstrated by the synergic interplay between photonic and electric stimuli within a single MoS2 synapse. An energy band model is proposed to further understand such a photoelectronic and spatio-temporal 4D hybrid coupling mechanism. These results might provide an alternative solution for the size-scaling and intellectualization campaign of the post-Moore era, and for more sophisticated photoelectronic hybrid computing in the emerging neuromorphic nanoelectronics.

17.
J Cell Physiol ; 234(8): 12757-12770, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-30537034

RESUMO

OBJECTIVE: This study aimed to investigate the expression levels of miR-133a-3p and collagen type I α 1 (COL1A1) in esophageal squamous cell carcinoma (ESCC) to find out the relationship between miR-133a-3p and COL1A1 and their influence on ESCC propagation, migration, invasion, and apoptosis. METHODS: The messenger RNA expression levels of miR-133a-3p and COL1A1 in ESCC were detected by quantitative reverse-transcription polymerase chain reaction. The expression of COL1A1 protein was examined via western blot analysis and immunohistochemistry assay. Cell propagation and apoptosis were, respectively, confirmed by CCK-8 and flow cytometry assay, whereas cell mobility and invasiveness were analyzed by wound healing assay and transwell assay. The targeted relationship between miR-133a-3p and COL1A1 was validated by the dual luciferase reporter assay. The tumor xenograft model was constructed to further verify the impact of miR-133a-3p on esophageal squamous tumor growth and COL1A1 expression in vivo. RESULTS: miR-133a-3p was found low-expressed whereas COL1A1 was highly expressed in esophageal squamous cancer tissue and cells. The expression of miR-133a-3p was negatively correlated with COL1A1 expression. The dual luciferase reporter gene assay confirmed that miR-133a-3p directly targeted COL1A1 and suppressed its expression. Cell Counting Kit-8 assay, transwell assay, and flow cytometry analysis demonstrated that COL1A1 promoted ESCC propagation and invasion and suppressed cell apoptosis, whereas miR-133a-3p reversed such adverse effects by regulating COL1A1. CONCLUSIONS: miR-133a-3p inhibited the cell propagation, invasion, and migration and facilitated apoptosis in ESCC by targeting COL1A1.

18.
Nanoscale ; 11(5): 2162-2169, 2019 Jan 31.
Artigo em Inglês | MEDLINE | ID: mdl-30519691

RESUMO

One-dimensional semiconducting SnO2 nanowires with wide bandgaps are promising candidates to build many important optoelectronic devices. Because building these devices involves the assembly of nanowires into complex structures, manipulation of the active materials needs to be done with high spatial precision. In this paper, an optical tweezer system, comprising a spatial light-modulator, a microscope, and optical elements, is used to individually trap, transfer, and assemble SnO2 nanowires into two-terminal photodetectors in a liquid environment. After the assembly using optical trapping, the two ends of the SnO2 nanowire photodetectors, which are connected with the electrodes, were further stabilized using a focused laser. During exposure to 275 nm deep-ultraviolet light, the as-assembled photodetectors show a high Iph/Idark ratio of 2.99 × 105, a large responsivity of 4.3 × 104 A W-1, an excellent external quantum efficiency of 1.94 × 105, and a high detectivity of 2.32 × 1013 Jones. The photoresponse-speed of the devices could be improved further using passivation with a polymer. The rise and decay times are about 60 ms and 100 ms, respectively. As a result of this study, we can confirm that non-contact optical trapping can enable the construction of nanowire architectures for optoelectronic, bioelectronic, and other devices.

19.
Medicine (Baltimore) ; 97(50): e13615, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30558040

RESUMO

The inflammation-based Glasgow Prognostic Score (GPS), which involves C-reactive protein and serum albumin levels, has been reported to be a strong independent predictor of mortality in many cancers. This study aimed to investigate whether the GPS is associated with mortality in patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI).In this study, 406 consecutive patients with STEMI at our emergency department (ED) who were undergoing pPCI were prospectively enrolled and assigned a GPS of 0, 1, or 2. Kaplan-Meier survival and multivariable Cox regression analyses were used to evaluate the associations between the GPS and long-term mortality.Twenty-three patients (5.7%) died at the hospital, and 37 (9.7%) died during follow-up (14.4 [9.3-17.6] months). Compared with patients with a lower GPS, those with a higher GPS had significantly higher in-hospital mortality (GPS = 0 vs GPS = 1 vs GPS = 2: 3.3% vs 6.3% vs 28.0%, P < .001), follow-up mortality (4.6% vs 14.3% vs 55.6%, P < .001), and cumulative mortality (9.6% vs 21.1% vs 71.1%, P < .001). Multivariable Cox regression analysis revealed that in patients with a GPS of 1 and 2 (versus 0), the multivariable adjusted hazard ratios (HR) for all-cause mortality were 2.068 (95% CI: 1.082-3.951, P = .028) and 8.305 (95% CI: 4.017-17.171, P < .001), respectively, after controlling for all of the confounding factors. Subgroup analysis showed that a higher GPS was associated with an increased risk of cumulative mortality in the different subgroups.The GPS on admission may be useful for stratifying the risk of adverse outcomes in patients with STEMI undergoing pPCI in the ED.


Assuntos
Inflamação/classificação , Prognóstico , Infarto do Miocárdio com Supradesnível do Segmento ST/classificação , Idoso , Biomarcadores/análise , Biomarcadores/sangue , Proteína C-Reativa/análise , Estudos de Coortes , Feminino , Escala de Resultado de Glasgow/normas , Mortalidade Hospitalar , Humanos , Estimativa de Kaplan-Meier , Masculino , Pessoa de Meia-Idade , Modelos de Riscos Proporcionais , Estudos Prospectivos , Análise de Regressão , Fatores de Risco , Infarto do Miocárdio com Supradesnível do Segmento ST/mortalidade , Albumina Sérica/análise
20.
Nanoscale ; 10(46): 21782-21789, 2018 Nov 29.
Artigo em Inglês | MEDLINE | ID: mdl-30431038

RESUMO

We have provided a no-touch and inexpensive technique to present the three-dimensional (3D) structure of two-dimensional (2D) films, based on the equal thickness interference fringes. In these experiments, the interference colors were obtained by an optical microscope without contact with the sample, and the 3D structures of curved 2D membranes were reconstructed by MATLAB programs in real time. The theoretical model and experimental results both showed that natural bending can improve the stiffness of 2D materials by more than 10 times. By using micro-droplets as the workbench, the 3D bending orientation and curvature of the 2D material could be manipulated and detected at the same time. The selected 3D curved shapes of cylindrical, ellipsoid and saddle surfaces can increase the bending stiffness over 10 000 times based on theoretical calculation. A saddle-shaped 3D structure (classic crisps shape) is predicted to obtain the maximum bending stiffness. Herein, a simple and practical method to comprehensively detect the basic deformation of 2D membranes is proposed, which should be promoted to explore the out-of-plane mechanical properties of 2D materials under external fields.

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