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1.
Int J Mol Sci ; 23(24)2022 Dec 14.
Artigo em Inglês | MEDLINE | ID: mdl-36555570

RESUMO

Surface-enhanced Raman spectroscopy (SERS) is an ultra-sensitive and rapid technique that is able to significantly enhance the Raman signals of analytes absorbed on functional substrates by orders of magnitude. Recently, semiconductor-based SERS substrates have shown rapid progress due to their great cost-effectiveness, stability and biocompatibility. In this work, three types of faceted Co3O4 microcrystals with dominantly exposed {100} facets, {111} facets and co-exposed {100}-{111} facets (denoted as C-100, C-111 and C-both, respectively) are utilized as SERS substrates to detect the rhodamine 6G (R6G) molecule and nucleic acids (adenine and cytosine). C-100 exhibited the highest SERS sensitivity among these samples, and the lowest detection limits (LODs) to R6G and adenine can reach 10-7 M. First-principles density functional theory (DFT) simulations further unveiled a stronger photoinduced charge transfer (PICT) in C-100 than in C-111. This work provides new insights into the facet-dependent SERS for semiconductor materials.


Assuntos
Nanopartículas Metálicas , Nanopartículas Metálicas/química , Análise Espectral Raman/métodos , Semicondutores
2.
Adv Mater ; : e2208190, 2022 Nov 23.
Artigo em Inglês | MEDLINE | ID: mdl-36417767

RESUMO

In contrast to closed-shell luminescent molecules, the electronic ground state and lowest excited state in organic luminescent radicals are both spin doublet, which results in spin-allowed radiative transitions. However, successful examples of highly efficient organic luminescent radicals are still rare. Most reported luminescent radicals with high photoluminescent quantum efficiency (PLQE) have a donor-acceptor (D-A•) chemical structure where an electron-donating group is covalently attached to an electron-withdrawing radical core (A•). Understanding the main factors that define the efficiency and stability of D-A• type luminescent radicals remains challenging. Here, we designed and synthesized a series of tri(2,4,6-trichlorophenyl)methyl (TTM) radical derivatives with donor substituents varying by their extent of conjugation and their number of imine-type nitrogen atoms. The experimental results suggest that the luminescence efficiency and stability of the radicals are proportional to the degree of conjugation but inversely proportional to the number of imine nitrogen atoms in the substituents; as a result, the molecule with the average extent of conjugation and number of imine nitrogen atoms in the substituent has the highest PLQE (89%). These experimental trends are very well reproduced by density functional theory calculations. The theoretical results indicate that both the luminescence efficiency and radical stability are related to the energy difference between the charge transfer (CT) and local-excitation (LE) states, which decreases as either the number of imine nitrogen atoms in the substituent increases or its conjugation length decreases. Our study underlines that the optimization of the CT energy is critical to maximize the emitter PLQE: On the one hand, the CT energy has to be high enough in order to reduce the non-radiative decay rate related to the energy-gap law; on the other hand, it should remain low with respect to the LE-state energies to prevent hybridization with the TTM local excitations. This article is protected by copyright. All rights reserved.

3.
J Psychiatr Res ; 156: 628-638, 2022 Nov 07.
Artigo em Inglês | MEDLINE | ID: mdl-36375230

RESUMO

Schizophrenia (SZ) is a serious neurodevelopmental disorder. As the etiology of SZ is complex and the pathogenesis is not thoroughly understood, the diagnosis of different subtypes still depends on the subjective judgment of doctors. Therefore, there is an urgent need to develop early objective laboratory diagnostic biomarkers to screen different subtypes of patients as early as possible, and to implement targeted prevention and precision medicine to reduce the risk of SZ and improve patients' quality of life. In this study, untargeted metabolomics and 16S rDNA sequencing were used to analyze the differences in metabolites and gut microflora among 28 patients with two types of schizophrenia and 11 healthy subjects. The results showed that the metabolome and sequencing data could effectively discriminate among paranoid schizophrenia patients, undifferentiated schizophrenia patients and healthy controls. We obtained 65 metabolites and 76 microorganisms with significant changes, and fecal metabolite composition was significantly correlated with the differential genera (|r|>0.5), indicating that there was a regulatory relationship between the gut microbiota and the host metabolites. The gut microbiome, as an objective and measurable index, showed good diagnostic value for distinguishing schizophrenia patients from healthy people, especially with a combination of several differential microorganisms, which had the best diagnostic effect (AUC>0.9). Our results are conducive to understanding the complicated metabolic changes in SZ patients and providing valuable information for the clinical diagnosis of SZ.

4.
Artigo em Inglês | MEDLINE | ID: mdl-36448542

RESUMO

As rising star materials, single-atom and dual-atom catalysts have been widely reported in the electro-catalysis area. To answer the key question: single-atom and dual-atom catalysts, which is better for electrocatalytic urea synthesis? we design two types of catalysts via a vacancy-anchorage strategy: single-atom Pd1-TiO2 and dual-atom Pd1Cu1-TiO2 nanosheets. An ultrahigh urea activity of 166.67 molurea molPd-1 h1 with the corresponding 22.54 % Faradaic efficiency at -0.5 V vs. reversible hydrogen electrode (RHE) is achieved over Pd1Cu1-TiO2, which is much higher than that of Pd1-TiO2. Various characterization including an in-situ diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) and theoretical calculations demonstrate that dual-atom Pd1Cu1 site in Pd1Cu1-TiO2 is more favorable for producing urea, which experiences a C-N coupling pathway with a lower energy barrier compared with Pd1 in Pd1-TiO2.

5.
Int J Mol Sci ; 23(19)2022 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-36232948

RESUMO

Patulin (PAT) is a common mycotoxin in the food industry, and is found in apple products in particular. Consumption of food or feed contaminated with PAT can cause acute or chronic toxicity in humans and animals. Lactiplantibacillus plantarum CCFM1287 is a probiotic strain that effectively degrades PAT in PBS and food systems. In this study, it was found that the concentration of PAT (50 mg/L) in MRS medium decreased by 85.09% during the first stages of CCFM1287 growth, and this change was consistent with the first-order degradation kinetic model. Meanwhile, the regulation of oxidative stress by L. plantarum CCFM1287 in response to PAT exposure and metabolic changes that occur during PAT degradation were investigated. The degree of intracellular damage was attenuated after 16 h of exposure compared to 8 h. Meanwhile, metabolomic data showed that 30 and 29 significantly different metabolites were screened intracellularly in the strain after 8 h and 16 h of PAT stress at 50 mg/L, respectively. The results of pathway enrichment analysis suggested that the purine metabolic pathway was significantly enriched at both 8 h and 16 h. However, as is consistent with the performance of the antioxidant system, the changes in Lactiplantibacillus diminished with increasing time of PAT exposure. Therefore, this study helps to further explain the mechanism of PAT degradation by L. plantarum CCFM1287.


Assuntos
Malus , Patulina , Probióticos , Animais , Antioxidantes , Humanos , Malus/metabolismo , Patulina/metabolismo , Patulina/toxicidade , Purinas
6.
Food Res Int ; 160: 111640, 2022 10.
Artigo em Inglês | MEDLINE | ID: mdl-36076376

RESUMO

The potential probiotic function of Latilactobacills curvatus has attracted the attention of researchers. To explore the differences in the genomes of L. curvatus, nine strains were isolated from various sources, including feces and fermented vegetables and compared with 25 strains from the NCBI database. The findings indicated that the average genome size, GC content, and CDS of L. curvatus were 1.94 MB, 41.9%, and 1825, respectively. Its core genome is associated with transcription, translation, carbohydrate transport and metabolism, and defense functions. The pan-genome of L. curvatus was in a closed state. The genetic diversity of L. curatus is mainly manifested in its ability to use carbohydrates, antibiotic resistance, bacteriocin operon, and polymeric regularly interspaced short palindromic repeats (CRISPR)-Cas for bacterial immunity. The CRISPR system of 34 strains of L. curvatus was predominantly found to be of the IIA type with a few IIC and IE types. These findings will contribute to a better understanding of this species.


Assuntos
Bacteriocinas , Bacteriófagos , Bacteriocinas/genética , Bacteriófagos/genética , Sistemas CRISPR-Cas , Metabolismo dos Carboidratos/genética , Resistência Microbiana a Medicamentos , Genoma Bacteriano/genética , Genótipo , Fenótipo
7.
Biomolecules ; 12(8)2022 07 29.
Artigo em Inglês | MEDLINE | ID: mdl-36008951

RESUMO

The inefficient use of water-insoluble drugs is a major challenge in drug delivery systems. Core-sheath fibers with various shell thicknesses based on cellulose acetate (CA) were prepared by the modified triaxial electrospinning for the controlled and sustained release of the water-insoluble Chinese herbal active ingredient curcumin. The superficial morphology and internal structure of core-sheath fibers were optimized by increasing the flow rate of the middle working fluid. Although the prepared fibers were hydrophobic initially, the core-sheath structure endowed fibers with better water retention property than monolithic fibers. Core-sheath fibers had flatter sustained-release profiles than monolithic fibers, especially for thick shell layers, which had almost zero-order release for almost 60 h. The shell thickness and sustained release of drugs brought about a good antibacterial effect to materials. The control of flow rate during fiber preparation is directly related to the shell thickness of core-sheath fibers, and the shell thickness directly affects the controlled release of drugs. The fiber preparation strategy for the precise control of core-sheath structure in this work has remarkable potential for modifying water-insoluble drug release and improving its antibacterial performance.


Assuntos
Curcumina , Nanofibras , Antibacterianos/farmacologia , Curcumina/farmacologia , Preparações de Ação Retardada/química , Preparações de Ação Retardada/farmacologia , Nanofibras/química , Água
8.
Biochem Biophys Res Commun ; 622: 122-128, 2022 09 24.
Artigo em Inglês | MEDLINE | ID: mdl-35849953

RESUMO

Two glycosylated naphthacemycins (naphthacemycins D1 and D2) were identified in Streptomyces sp. N12W1565. These two compounds not only showed antimicrobial potential against bacteria but also exhibited more aqueous solubility than naphthacemycins. Furthermore, the whole genome of Streptomyces sp. N12W1565 has been sequenced, the natY gene, located outside the biosynthetic gene cluster encoding a D-glucose glycosyltransferase, was identified to mediate glycosylation in the phenolic hydroxyl of the naphthacemycin core scaffold. Glycosyltransferase was elucidated in vitro by using a homologous enzyme, which showed potential as a biocatalyst.


Assuntos
Streptomyces , Antibacterianos/farmacologia , Glicosilação , Glicosiltransferases/genética , Glicosiltransferases/metabolismo , Família Multigênica
9.
J Nanobiotechnology ; 20(1): 244, 2022 May 28.
Artigo em Inglês | MEDLINE | ID: mdl-35643572

RESUMO

BACKGROUND: The diversified combination of nanostructure and material has received considerable attention from researchers to exploit advanced functional materials. In drug delivery systems, the hydrophilicity and sustained-release drug properties are in opposition. Thus, difficulties remain in the simultaneous improve sustained-release drug properties and increase the hydrophilicity of materials. METHODS: In this work, we proposed a modified triaxial electrospinning strategy to fabricate functional core-shell fibres, which could elaborate design of shell component for manipulating the sustained-release drug. Cellulose acetate (CA) was designed as the main polymeric matrix, whereas polyethylene glycol (PEG) was added as a hydrophilic material in the middle layer. Cur, as a model drug, was stored in the inner layer. RESULTS: Scanning electron microscopy (SEM) results and transmission electron microscopy (TEM) demonstrated that the cylindrical F2-F4 fibres had a clear core-shell structure. The model drug Cur in fibres was verified in an amorphous form during the X-ray diffraction (XRD) patterns, and Fourier transformed infrared spectroscopy (FTIR) results indicated good compatibility with the CA matrix. The water contact angle test showed that functional F2-F4 fibres had a high hydrophilic property in 120 s and the control sample F1 needed over 0.5 h to obtain hydrophilic property. In the initial stage of moisture intrusion into fibres, the quickly dissolved PEG component guided the water molecules and rapidly eroded the internal structure of functional fibres. The good hydrophilicity of F2-F4 fibres brought relatively excellent swelling rate around 4600%. Blank outer layer of functional F2 fibres with 1% PEG created an exciting opportunity for providing a 96 h sustained-release drug profile, while F3 and F4 fibres with over 3% PEG provided a 12 h modified drug release profile to eliminate tailing-off effect. CONCLUSION: Here, the functional F2-F4 fibres had been successfully produced by using the advanced modified triaxial electrospinning nanotechnology with different polymer matrices. The simple strategy in this work has remarkable potential to manipulate hydrophilicity and sustained release of drug carriers, meantime it can also enrich the preparation approaches of functional nanomaterials.


Assuntos
Nanofibras , Preparações de Ação Retardada , Portadores de Fármacos/química , Liberação Controlada de Fármacos , Nanofibras/química , Polietilenoglicóis/química , Água
10.
Zhongguo Gu Shang ; 35(3): 276-80, 2022 Mar 25.
Artigo em Chinês | MEDLINE | ID: mdl-35322620

RESUMO

OBJECTIVE: Osteosarcoma(OS) and Ewing's sarcoma (EWS) are the two most common primary malignant bone tumors in children. The aim of the study was to identify key genes in OS and EWS and investigate their potential pathways. METHODS: Expression profiling (GSE16088 and GSE45544) were obtained from GEO DataSets. Differentially expressed genes were identified using GEO2R and key genes involved in the occurrence of both OS and EWS were selected using venn diagram. Gene ontology and pathway enrichment analyses were performed for the ensembl. Protein-protein interaction (PPI) networks were established by STRING. Further, UCSC was used to predict the transcription factors of the cell division cycke 5-like(CDC5L) gene, and GEPIA was used to analyze the correlation between the transcription factors and the CDC5L gene. RESULTS: The results showed that CDC5L gene was the key gene involved in the pathogenesis of OS and EWS. The gene is mainly involved in mitosis, and is related to RNA metabolism, processing of capped intron-containing pre-mRNA, mRNA and pre-mRNA splicing. CONCLUSION: CDC5L, as a key gene, plays a role in development of OS and EWS, which may be reliable targets for diagnosis and treatment of these primary malignant tumors.


Assuntos
Neoplasias Ósseas , Proteínas de Ciclo Celular , Osteossarcoma , Proteínas de Ligação a RNA , Sarcoma de Ewing , Neoplasias Ósseas/genética , Neoplasias Ósseas/patologia , Proteínas de Ciclo Celular/genética , Criança , Biologia Computacional , Perfilação da Expressão Gênica , Humanos , Osteossarcoma/genética , Proteínas de Ligação a RNA/genética , Sarcoma de Ewing/genética
11.
Polymers (Basel) ; 14(3)2022 Jan 24.
Artigo em Inglês | MEDLINE | ID: mdl-35160459

RESUMO

In a drug delivery system, the physicochemical properties of the polymeric matrix have a positive impact on the bioavailability of poorly water-soluble drugs. In this work, monolithic F1 fibers and coaxial F2 fibers were successfully prepared using polyvinylpyrrolidone as the main polymer matrix for drug loading and the poorly water-soluble curcumin (Cur) as a model drug. The hydrophobic poly (3-hydroxybutyric acid-co-3-hydroxyvaleric acid) (PHBV) was designed as a blank layer to change the hydrophilicity of the fiber and restrain the drug dissolution rate. The curved linear morphology without beads of F1 fibers and the straight linear morphology with few spindles of F2 fibers were characterized using field-emission environmental scanning electron microscopy. The amorphous forms of the drug and its good compatibility with polymeric matrix were verified by X-ray diffraction and attenuated total reflectance Fourier transformed infrared spectroscopy. Surface wettability and drug dissolution data showed that the weaker hydrophilicity F2 fibers (31.42° ± 3.07°) had 24 h for Cur dissolution, which was much longer than the better hydrophilic F1 fibers (15.31° ± 2.79°) that dissolved the drug in 4 h.

12.
Clin Exp Rheumatol ; 40(3): 501-513, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33886462

RESUMO

OBJECTIVES: Adipokine resistin is highly expressed in the serum and synovial uid (SF) of patients with knee osteoarthritis (KOA) but its pathogenic role in KOA remains unclear. We aimed to explore the mechanism of resistin/CAP1 in human KOA chondrocytes. METHODS: We enrolled 103 patients with radiographic KOA and 86 healthy participants as controls. Resistin levels in serum and SF were determined by enzyme-linked immunosorbent assay (ELISA). CAP1 expression was measured in cartilage tissues using immunohistochemistry, quantitative real-time polymerase chain reaction (qRT-PCR), and western blot. Effects of resistin on chondrocytes and CAP1 were evaluated via qRT-PCR and co-immunoprecipitation. The roles of CAP1, p38-MAPK, and NF-κB signalling pathways in KOA development were evaluated using adenovirus-mediated CAP1 short hairpin RNA, qRT-PCR, western blot, and ELISA. RESULTS: Resistin expression in serum and SF was elevated in severe radiographic KOA. CAP1 levels were higher in KOA cartilage and were positively correlated with resistin expression. Resistin promoted CCL3, CCL4, MMP13, and ADAMTS-4 expression through the CAP1 receptor. Resistin also directly bound to CAP1, as confirmed by co-immunoprecipitation. CAP1 knockdown in chondrocytes attenuated resistin-induced expression of CCL3, CCL4, MMP13, and ADAMTS-4 and activated p38-MAPK and NF-κB signalling pathways. CONCLUSIONS: Resistin binds CAP1 and upregulates the expression of proinflammatory cytokines and matrix-degrading enzymes via p38-MAPK and NF-κB signalling in human chondrocytes.


Assuntos
Condrócitos , NF-kappa B , Proteínas de Ciclo Celular/metabolismo , Proteínas de Ciclo Celular/farmacologia , Células Cultivadas , Quimiocinas , Condrócitos/metabolismo , Proteínas do Citoesqueleto/metabolismo , Humanos , Metaloproteinases da Matriz/metabolismo , Metaloproteinases da Matriz/farmacologia , NF-kappa B/metabolismo , Oligopeptídeos , Resistina , Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo
13.
Front Neurol ; 12: 618055, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34393964

RESUMO

Recent advances in neuroimaging technologies have provided insights into detecting residual consciousness and assessing cognitive abilities in patients with disorders of consciousness (DOC). Functional near-infrared spectroscopy (fNIRS) is non-invasive and portable and can be used for longitudinal bedside monitoring, making it uniquely suited for evaluating brain function in patients with DOC at appropriate spatiotemporal resolutions. In this pilot study, an active command-driven motor imagery (MI) paradigm based on fNIRS was used to detect residual consciousness in patients with prolonged DOC. A support vector machine (SVM) classifier was used to classify yes-or-no responses. The results showed that relatively reliable responses were detected from three out of five patients in a minimally consciousness state (MCS). One of the patients answered all the questions accurately when assessed according to this method. This study confirmed the feasibility of using portable fNIRS technology to detect residual cognitive ability in patients with prolonged DOC by active command-driven motor imagery. We hope to detect the exact level of consciousness in DOC patients who may have a higher level of consciousness.

14.
J Hazard Mater ; 420: 126609, 2021 10 15.
Artigo em Inglês | MEDLINE | ID: mdl-34329113

RESUMO

To effectively address the serious human health challenges and ecological damage caused by organic dyes in wastewater, we developed a novel bionic adsorbent (LDH@PDA@MPNs) for the selective adsorption and removal of malachite green (MG) and crystalline violet (CV). The adsorbent was prepared using a facile two-step method based on mussel-inspired chemistry and metal complexation. The physicochemical structure, surface morphology, and composition of the LDH@PDA@MPNs were characterized by scanning electron microscopy, Fourier-transform infrared spectrometry, X-ray photoelectron spectroscopy, and thermogravimetric analysis. Adsorption of MG and CV with the LDH@PDA@MPNs was evaluated. Under optimal conditions, the maximum adsorption of MG and CV by the adsorbent was 89.608 and 40.481 mg/g, respectively. The adsorption kinetics showed that the experimental data were in good agreement with the pseudo-second-order kinetic model, and the equilibrium adsorption isotherm data fitted well with the Freundlich model. The thermodynamic results indicated that the adsorption of the dyes on LDH@PDA@MPNs was a spontaneous endothermic process. Importantly, the bionic adsorbent not only shows high removal efficiency by easy regeneration with low-cost reagents but also exhibits high selectivity for dyes in both single and binary systems. Therefore, LDH@PDA@MPNs have the potential to adsorb and remove dyes from complex wastewater solutions.


Assuntos
Corantes , Poluentes Químicos da Água , Adsorção , Biônica , Humanos , Concentração de Íons de Hidrogênio , Hidróxidos , Indóis , Polímeros , Polifenóis , Poluentes Químicos da Água/análise
15.
Food Chem ; 352: 129187, 2021 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-33652196

RESUMO

A novel covalent organic framework material (3DGA@COFs), for use as a solid-phase dispersion sorbent, has been synthesized for extracting organophosphorus pesticides (OPs) from vegetables. The prepared 3DGA@COFs material exhibited many advantageous features, including a large specific surface area (127.95 m2/g) and high pore volume (0.0344 cm3/g), which made it an ideal sorbent for sample pretreatment. The experimental conditions affecting extraction performance (adsorbent type, adsorbent amount, reaction time, pH, ionic concentration, and eluent) were optimized systematically. The extracted analytes were detected by HPLC-MS/MS. Under optimized conditions, the proposed method exhibited a wide linear range (0.5-100 µg/L) and low limits of detection (0.01-0.14 µg/L). The recoveries (75.40%-102.13%) satisfied the requirements for a precise detection method. The proposed method was successfully used for determining malathion, triazophos, quinalphos in lettuce, tomato and cucumber samples, thus indicating the potential of using 3DGA@COFs materials for pretreating vegetable samples.


Assuntos
Grafite/química , Hidrogéis/química , Estruturas Metalorgânicas/síntese química , Compostos Organofosforados/isolamento & purificação , Praguicidas/isolamento & purificação , Extração em Fase Sólida/métodos , Verduras/química , Adsorção , Técnicas de Química Sintética , Contaminação de Alimentos/análise , Concentração de Íons de Hidrogênio , Limite de Detecção , Estruturas Metalorgânicas/química , Compostos Organofosforados/análise , Compostos Organofosforados/química , Praguicidas/análise , Praguicidas/química , Fatores de Tempo
16.
Artigo em Inglês | MEDLINE | ID: mdl-33578273

RESUMO

Detection of low levels of triazole fungicides in agricultural product matrices is important. Although several detection methods have been developed, all have some drawbacks, such as being time-consuming, requiring complex sample pretreatment, and consuming large volumes of organic solvents. There is an urgent need for a simple and rapid detection method for triazole fungicides. In this study, the adsorbent composite material magnetic MOFs based on Fe3O4-MWCNT was synthesized by in-situ polymerization at room temperature, and was applied to extract triazole pesticides from fruits and vegetables. High-performance liquid chromatography-tandem mass spectrometry was used for quantification. Under optimized conditions, the constructed detection method showed a low detection (LOD) of 0.52-1.83 µg/L (S/N = 3) and wide linear range of 5.00-500.00 µg/L for triazole fungicides in the fruit and vegetable samples. The method recovery for spiked fungicides (10, 50, and 100 µg/L) in cabbage, spinach, orange juice, and apple juice ranged from 62.80% to 94.20%. The constructed detection method has a lower detection limit than previously reported methods and has a higher sensitivity for triazole pesticide residues in complex matrices.


Assuntos
Sucos de Frutas e Vegetais/análise , Estruturas Metalorgânicas/química , Resíduos de Praguicidas , Extração em Fase Sólida/métodos , Triazóis , Cromatografia Líquida de Alta Pressão , Limite de Detecção , Modelos Lineares , Nanopartículas de Magnetita/química , Resíduos de Praguicidas/análise , Resíduos de Praguicidas/isolamento & purificação , Reprodutibilidade dos Testes , Espectrometria de Massas em Tandem , Triazóis/análise , Triazóis/isolamento & purificação
17.
Nanomaterials (Basel) ; 12(1)2021 Dec 22.
Artigo em Inglês | MEDLINE | ID: mdl-35009970

RESUMO

A unique self-standing membrane composed of hierarchical thermoplastic polyurethane (TPU)/polyacrylonitrile (PAN) fibers is prepared by the electrospinning technique, followed by a simple dip-coating process. Fe3O4 nanoparticles are uniformly anchored on TPU/PAN fibers during the electrospinning process, enabling the membrane to achieve effective electromagnetic interference shielding (EMI SE) performance. Such a hybrid membrane has a high magnetization of 18.9 emu/g. When MXene (Ti3C2Tx) layers are further loaded on the TPU/PAN/Fe3O4NPs hybrid membrane, its EMI SE performance in the X band can exceed 30 dB due to the hydrogen bonds generated between the macromolecular chain of PAN and the functional group (Tx) on the surface of MXene. Simultaneously, the interfacial attraction between MXene and the TPU/PAN/Fe3O4NPs substrate is enhanced. The EMI SE mechanism of the hybrid membrane indicates that this film has great potential in the fields of wearable devices and flexible materials.

18.
ACS Appl Bio Mater ; 4(5): 4345-4353, 2021 05 17.
Artigo em Inglês | MEDLINE | ID: mdl-35006846

RESUMO

Various single-atom materials exhibit distinguished performances in catalysis and biology. To boost their applications, single-atom-based strategies are highly demanded to exhibit repeatable functions on advanced wearable substrates. However, single-atom approaches are rarely reported to anchor on wearable materials, i.e., widely applied cotton fabrics. Here, we developed a simple method of loading uniformly dispersed single tungsten atoms on cotton via ordinary direct-dye processing to exhibit superior sustainable functions. The single sites of tungsten atom centers are constructed by binding oxygen-coordinated single tungsten atom on the cotton fabric surface via -COOH groups. Consequently, the band gap of single sites decreases significantly to 2.75 from 3.03 eV. Therefore, the single-site-modified cotton exhibits excellent visible-light-driven (>420 nm) photocatalytic degradation efficiency of organic dyes, which exceeds other reported cotton-based materials by nearly two orders of magnitude. Furthermore, the single-site-modified cotton also exhibits great antibacterial performance due to reactive oxygen species. Moreover, the cotton with anchored single sites possesses great washing-resistance ability during 20 laundry cycles under soap-washing conditions. After recycling, the single sites on cotton have no obvious changes in the microstructure, which demonstrates the success of our sustainable strategy of single sites anchored on cotton. The single-site technique can be extended to many other elemental atoms on various wearable devices, providing a playground for functional material communities.


Assuntos
Antibacterianos/farmacologia , Materiais Biocompatíveis/farmacologia , Fibra de Algodão , Luz , Staphylococcus aureus/efeitos dos fármacos , Tungstênio/farmacologia , Animais , Antibacterianos/síntese química , Antibacterianos/química , Materiais Biocompatíveis/síntese química , Materiais Biocompatíveis/química , Catálise , Teste de Materiais , Camundongos , Camundongos Endogâmicos C57BL , Testes de Sensibilidade Microbiana , Tamanho da Partícula , Processos Fotoquímicos , Tungstênio/química , Cicatrização/efeitos dos fármacos
20.
J Med Food ; 24(1): 1-9, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33370169

RESUMO

Allergic rhinitis (AR) is an IgE-mediated chronic inflammatory disease of the allergic nasal mucosa. It has a significant effect on quality life; most patients with AR also suffer from sleep disorders, mood disorders, and deterioration in social relationships. As increasing numbers of medicinal plants show productive anti-inflammatory activity against inflammatory diseases, there is growing interest in natural medicinal plant ingredients. To this end, we selected Astragalus polysaccharides (APS) to evaluate its anti-inflammatory effect on ovalbumin-induced AR rats, and we further explored its impact on NLRP3 inflammasome activation and NOD2-mediated NF-κB activation. We found that APS can alleviate the nasal symptom of AR rats and attenuate pathological alterations. APS also reduced the inflammatory cytokine levels. APS not only inhibited the NLRP3 inflammasome activation but also inhibited NF-κB activation by decreasing NOD2 expression and blocking the phosphorylation of NF-κB (p65). In conclusion, APS can effectively improve the inflammatory symptoms of nasal mucosa in AR rats, which may be mediated by the inhibition of NLRP3 inflammasome activation and NOD2-mediated NF-κB activation. These findings indicate that APS has the potential to be used as a therapeutic agent for AR.


Assuntos
Inflamassomos/antagonistas & inibidores , Proteína 3 que Contém Domínio de Pirina da Família NLR/antagonistas & inibidores , Proteína Adaptadora de Sinalização NOD2/metabolismo , Polissacarídeos/uso terapêutico , Rinite Alérgica/tratamento farmacológico , Fator de Transcrição RelA/metabolismo , Animais , Astrágalo (Planta)/química , Inflamassomos/metabolismo , Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo , Ovalbumina , Ratos , Rinite Alérgica/induzido quimicamente
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