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2.
Clin Cosmet Investig Dent ; 11: 163-170, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31308759

RESUMO

Prader-Willi syndrome (PWS) is a rare complex multisystem disorder and presents several aspects related to dentistry. The purpose of this review is to present current perspectives about oral health in patients with PWS. Delay development, hyperphagia, foamy and highly viscous saliva raise the risk of caries and contribute to tooth wear. Cariogenic foods uncontrolled consumption allows to obesity and dental problems progress worsening systemic disorders. These factors can be controlled. The success in follow-ups with caries free and oral health controlled demonstrate the importance of multidisciplinary team intervention corroborated by support at home from birth to adulthood. Thereby, current perspective on the disease is that there is possibility of proper maintenance of oral health in PWS patients. Guided care interferes positively with the overall well-being and quality of life of the individual with PWS and their family. A multidisciplinary team with a focus on teaching patients and family members will help minimize eventual problems.

3.
Ultrason Sonochem ; 56: 437-446, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31101282

RESUMO

The aim of this study was determinate the best sonochemical time in order to obtain better bone characteristics when a bioactive material (Biogran) is used in the filling periimplantar defects. In this study, 32 rats were submitted to surgical proceedings to create a periimplantar defect that was filled with Biogran receiving different sonochemical times: 15 (G1), 30 (G2), 45 (G3) or 90 min (G4). The biomaterial was characterized through X-ray diffraction and scanning electron microscopy (SEM). In vivo analysis was performed through micro CT, laser confocal microscopy, immunohistochemistry and evaluation of bone cytoarchitecture through hematoxylin and eosin (HE) staining. The data were submitted to statistical testing, considering a significance level of p < 0.05. Rx diffraction of pure bioglass showed that it is predominantly amorphous; otherwise, there are small peaks at 23° and 31°. SEM shows that the longer the sonochemical time, the less edges the biomaterial will present. Within the groups, G1 and G2 showed the best quantity and quality by micro CT (p > 0.05). The best bone turnover result was found in G1 and G2, otherwise the better results were related to neoformed bone area, bone mineral apposition rate and bone implant contact to G1 (p < 0.05). G1 had the best results in terms of bone cytoarchitectural evaluation and immunohistochemistry. It is possible to conclude that Biogran that received 15 min of sonochemical treatment (G1) presented periimplantar bone repair with the best extracellular matrix properties, including the best quality and quantity of vital bone.


Assuntos
Prótese Ancorada no Osso , Cerâmica/química , Ondas Ultrassônicas , Animais , Masculino , Ratos , Padrões de Referência , Tíbia/cirurgia
6.
Arch. Health Invest ; 8(2): 91-93, fev. 2019. ilus
Artigo em Português | BBO - Odontologia | ID: biblio-1006756

RESUMO

Em seu estudo, René Le Fort caracterizou três tipos de padrões fratura: Le Fort I, II e III. Na Le Fort I, observou um traço de fratura transverso na maxila acima do ápice dos dentes. Com o aumento da força de intensidade nos traumas, os três padrões de fratura Le Fort, são cada vez mais improváveis de acontecer de forma isolada. Com isso, este trabalho tem como objetivo apresentar um caso clínico de uma fratura do tipo Le Fort I em um paciente jovem, tratada com placas de titânio nos pilares caninos e zigomáticos da maxila(AU)


In his study, René Le Fort characterized three types of fracture patterns: Le Fort I, II and III. At Le Fort I, he observed a trace of transverse fracture in the maxilla above the apex of the teeth. With increased strength of intensity in traumas, the three Le Fort fracture patterns are increasingly unlikely to occur in isolation. The aim of this study is to present a case report of a Le Fort I type fracture in a young patient, treated with titanium plates in the canine and zygomatic maxillary pillars(AU)


En su estudio, René Le Fort caracterizó tres tipos de patrones fractura: Le Fort I, II y III. En la Le Fort I, observó un trazo de fractura transverso en la mandíbula encima del ápice de los dientes. Con el aumento de la fuerza de intensidad en los traumas, los tres patrones de fractura Le Fort, son cada vez más improbables de suceder de forma aislada. Con ello, este trabajo tiene como objetivo presentar un caso clínico de una fractura del tipo Le Fort I en un paciente joven, tratada con placas de titanio en los pilares caninos y zigomáticos de la mandíbula(AU)


Assuntos
Humanos , Masculino , Adolescente , Osteotomia de Le Fort , Maxila/cirurgia , Fixação de Fratura , Fraturas Maxilares
7.
Arch. Health Invest ; 8(1): 20-27, jan. 2019. ilus
Artigo em Português | BBO - Odontologia | ID: biblio-994972

RESUMO

A osteoporose é responsável por causar condições devastadoras no tecido ósseo elevando o risco de fraturas, constituindo uma problemática importante de saúde pública. É comum o uso de medicamentos, como os bifosfonatos para o controle dessa patologia. Contudo, a associação do uso desse medicamento com a osteonecrose dos maxilares vem sendo amplamente discutido na literatura, assim como a dificuldade da reabilitação desses pacientes como implantes e do protocolo de tratamento dessa condição. Assim sendo, o objetivo do presente trabalho foi realizar uma revisão de literatura para discutir as principais falhas associadas a instalação de implantes em pacientes portadores de osteonecrose dos maxilares associada ao uso de bifosfonatos (OMAB), assim como as possibilidades de tratamento, e relatar um caso clínico. As informações obtidas na revisão nos permitiu concluir que o uso de bifosfonatos orais, como o alendronato, é capaz de levar ao desenvolvimento da OMAB sendo necessária bastante precaução na reabilitação oral com implantes dentários, tanto em pacientes que fazem uso, como pacientes que apresentam risco de futura utilização de bifosfonatos para o tratamento de desordens esqueléticas(AU)


Osteoporosis is responsible for the devastating disease in the bone tissue, increasing the risk of fractures, constituting an important public health problem. It is common to use medications, such as bisphosphonates to control this pathology. The dosage application with osteonecrosis of the jaws has been discussed in the literature, as well as a rehabilitation task such as the implant and the transport protocol of this condition. Thus, the present study was carried out in a literature review on the main problems related to bisphosphonate-related osteonecrosis of the jaw (BRONJ) as well as the possibilities of treatment, and to report a clinical case. The information can be reviewed together, so that the use of oral bisphosphonates, such as alendronate, will be able to lead to the development of bisphosphonate-related osteonecrosis of the jaw (BRONJ), the future use of bisphosphonates for the treatment of skeletal disorders(AU)


La osteoporosis es responsable de causar condiciones devastadoras en el tejido óseo, elevando el riesgo de fracturas, constituyendo una problemática importante de salud pública. Es común el uso de medicamentos, como los bifosfonatos para el control de esa patología. Sin embargo, la asociación de los usos de este medicamento con la osteonecrosis de los maxilares viene siendo ampliamente discutida en la literatura, así como la dificultad de la rehabilitación dos pacientes como implantes y del protocolo de tramo de esa condición. Por lo tanto, el objetivo del presente trabajo fue realizar una revisión de literatura para discutir las principales fallas asociadas a la instalación de implantes en pacientes portadores de osteonecrosis maxilar inducida por bifosfonatos (ONMB), así como las posibilidades de tratamiento, e informar un caso clínico. La información obtenida en la revisión nos permitió concluir que el uso de bifosfonatos orales, como el alendronato, es capaz de llevar al desarrollo de la osteonecrosis maxilar inducida por bifosfonatos (ONMB), siendo necesario bastante precaución en la rehabilitación oral con implantes dentales, tanto en pacientes que hacen uso, como pacientes que presentan riesgo de la futura utilización de bifosfonatos para el tratamiento de desórdenes esqueléticos(AU)


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Implantes Dentários , Osteonecrose da Arcada Osseodentária Associada a Difosfonatos , Osteonecrose , Osteoporose/tratamento farmacológico , Alendronato
8.
Int J Oral Maxillofac Implants ; 34(1): 47­60, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30282090

RESUMO

PURPOSE: The purpose of this systematic review was to evaluate the outcome of dental implant treatment in fully edentulous patients who underwent Le Fort I osteotomy as a preprosthetic surgical technique. MATERIALS AND METHODS: A search was conducted of the PubMed (MEDLINE), EMBASE, Scopus, and Cochrane databases to identify records published from 1995 to 2017 dealing with Le Fort I osteotomy procedures for implant placement purposes. The primary outcomes of interest were the survival and success rates. The secondary outcomes consisted of the analysis of intra- and postsurgical complications and the surgical and prosthetic loading protocols. RESULTS: Overall, 20 articles were selected for data analysis. A total of 483 patients accounting for 3,596 implants were analyzed. The cumulative survival rate was 90.22% ± 0.8% at 10 years (mean: 59.20 ± 32.31 months). The cumulative success rate was 89.07% ± 1.3% at 10 years (mean: 62.82 ± 25 months). Higher survival rates were found for implants with a rough surface (P < .001) and for implants loaded with a delayed protocol (P < .001). The fracture of the palatine bone during the downfracture procedure was the main intrasurgical drawback, while sinus pathology and graft resorption were commonly observed during the postoperative healing. Surgical and prosthetic loading protocols were heterogenous. CONCLUSION: Based on this review, Le Fort I osteotomy might be considered a viable technique to recreate favorable conditions for implant-supported rehabilitations. Caution has to be taken when using machined implants, particularly in the case of a simultaneous approach.


Assuntos
Implantação Dentária Endo-Óssea/métodos , Implantes Dentários , Boca Edêntula/reabilitação , Osteotomia de Le Fort/métodos , Aumento do Rebordo Alveolar/métodos , Transplante Ósseo/métodos , Humanos , Fraturas Maxilomandibulares/etiologia , Maxila/cirurgia , Complicações Pós-Operatórias
9.
J Craniofac Surg ; 29(8): 2304-2306, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30277950

RESUMO

Atrophy of the alveolar ridge requires bone grafting at the implant site for rehabilitation of the masticatory function with dental implants. Despite the advances in the development of bone substitutes, autogenous bone graft remains the "criterion standard" because of its osteogenic, osteoinductive, osteoconductive potential, and non-immunogenic properties. However, harvesting of autogenous bone is not exempt from donor site morbidity. In this context, the use of autogenous bone derived from the proximal ulna might be a viable resource to obtain corticocancellous bone graft, as the harvesting from this donor site is associated with low morbidity. Thus, this article aimed to describe a case in which a maxillary sinus floor augmentation was performed by means of autogenous bone graft harvested from the proximal ulna, as the donor site. An appositional bone block graft harvested from the same region was used to augment the residual alveolar ridge. Clinically, healing proceeded uneventfully with no major complications. After 8 months, a proper amount of bone was found at the implant site, allowing a prosthetically driven implant insertion and subsequent implant-supported rehabilitation. Results were clinically and radiographically stable after a 3-year follow-up. The present case report suggested that proximal ulna as a donor site should be considered as a safe and reliable alternative for alveolar ridge augmentation. Besides the case presentation, a comprehensive review of the literature was also provided.


Assuntos
Processo Alveolar/cirurgia , Aumento do Rebordo Alveolar/métodos , Levantamento do Assoalho do Seio Maxilar/métodos , Ulna/transplante , Processo Alveolar/patologia , Atrofia , Implantes Dentários , Humanos , Masculino , Pessoa de Meia-Idade , Cicatrização
10.
Artigo em Inglês | LILACS-Express | ID: biblio-959756

RESUMO

ABSTRACT: Objective: This study was reduction of a bilateral mandibular fracture through the installation of dental implants with immediate loading, re-establishing the stomatognathic function of the patient. Case Report: A 58-year-old male patient seek the emergency room from hospital after suffering a motorcycle accident. After physical and imaging examinations was diagnosed with bilateral mandibular fracture. The treatment of choice, once the patient was edentulous, was the reduction and stabilization of the fracture with the installation of 5 dental implants with immediate loading. After 1 year of postoperative follow-up, the facial contour along with the occlusion were reestablished. Radiographically, it was found the proper placement of plates and screws with correct baseline realignment and maintenance of implant-supported prosthesis. Conclusion: In this case report with follow-up of 18 months, the functional prosthetic rehabilitation and immediate aesthetic with immediate loading system, after reduction and fixation of mandibular fractures proved to be a good treatment option.

11.
J Craniofac Surg ; 29(6): e555-e556, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-30015727

RESUMO

Myiasis has been defined as a pathologic condition where dipterous larvae are lodged in mammalian hosts causing an infestation, which feeds on living or dead tissue for at least a certain period inside the host and develops itself as parasites. In humans, the most commonly affected sites are the nose, eyes, skin wounds, sinuses, lungs, ears, gut, gall bladder, vagina, nasal cavities, and rarely the mouth because the oral tissues are rarely exposed to the external environment. The etiology of oral myiasis is usually related to local factors such as poor oral hygiene, periodontal disease and labial incompetence, and systemic factors such as neurologic deficits.


Assuntos
Infecções por HIV/complicações , HIV , Ivermectina/uso terapêutico , Larva , Doenças da Boca/tratamento farmacológico , Miíase/tratamento farmacológico , Toxoplasmose/complicações , Adulto , Animais , Antiparasitários/uso terapêutico , Diagnóstico Bucal , Humanos , Masculino , Doenças da Boca/complicações , Doenças da Boca/diagnóstico , Miíase/complicações , Miíase/diagnóstico , Toxoplasmose/diagnóstico
12.
J Appl Oral Sci ; 26: e20170470, 2018 Jul 10.
Artigo em Inglês | MEDLINE | ID: mdl-29995145

RESUMO

INTRODUCTION: The hypothesis of this study was that the peri-implant bone healing of the group of pinealectomized rats would differ from the control group. The samples were subjected to immunohistochemical, microtomographic (total porosity and connectivity density), and fluorochrome (mineralized surface) analyses. OBJECTIVES: The goal of this study was to investigate the cellular changes and bone remodeling dynamics along the bone/implant interface in pinealectomized rats. MATERIAL AND METHODS: The total of 18 adult male rats (Rattus norvegicus albinus, Wistar) was divided into three groups (n=6): control (CO), pinealectomized without melatonin (PNX) and pinealectomized with melatonin (PNXm). All animals were submitted to the first surgery (pinealectomy), except the CO group. Thirty days after the pinealectomy without melatonin, the second surgery was conducted, in which all animals received an implant in each tibia (36 titanium implants with surface treatment were installed - Implalife® São Paulo, SP, Brazil). By gavage, the rats of the PNX group received the vehicle solution, and the procedure. RESULTS: Immunohistochemical analysis for runt-related transcription factor 2 (RUNX2), alkaline phosphatase (ALP), osteopontin (OP) and osteocalcin (OC) showed that the bone repair process in the PNXm group was similar to that of the CO group, whereas the PNX group showed a delay. The microtomographic parameters of total porosity [Po(tot)] and bone surface (BS) showed no statistically significant differences, whereas for the connective density (Conn.Dn) a statistical difference was found between the CO and PNXm groups. Fluorochrome analysis of the active mineralized surface showed statistically significant difference between the CO and PNX and between the CO and PNXm groups. CONCLUSION: The absence of the pineal gland impaired the bone repair process during osseointegration, however the daily melatonin replacement was able to restore this response.


Assuntos
Conservadores da Densidade Óssea/farmacologia , Interface Osso-Implante , Melatonina/farmacologia , Osseointegração/efeitos dos fármacos , Glândula Pineal/cirurgia , Fosfatase Alcalina/análise , Animais , Subunidade alfa 1 de Fator de Ligação ao Core/análise , Implantação Dentária Endo-Óssea , Corantes Fluorescentes , Imuno-Histoquímica , Implantes Experimentais , Masculino , Osteocalcina/análise , Osteopontina/análise , Ratos Wistar , Reprodutibilidade dos Testes , Tíbia/efeitos dos fármacos , Tíbia/patologia , Tíbia/cirurgia , Titânio , Resultado do Tratamento , Microtomografia por Raio-X
13.
J Craniofac Surg ; 29(6): e617-e618, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-29916971

RESUMO

Necrotizing fasciitis (NF) is a devastating disease that typically affects immunocompromised patients, chronically debilitated patients or drug users, but can also affect healthy patients. Necrotizing fasciitis can rapidly produce septic shock and requires immediate surgical management of the necrotic tissue. It is a bacterial infection that progresses rapidly and has a high mortality generally caused by aerobic and anaerobic bacteria. The patient was immunocompromised and drug user. During treatment, a combination of broad-spectrum antibiotic therapy with Ciprofloxacin and Metronidazole, besides the use of activated charcoal dressing composed of carbonized fabric and impregnated with 0.15% silver nitrate enveloped by layer of fabric without activated carbon, chemical-mechanical debridement with hydrogen peroxide, 0.9% saline, and povidone iodine. According to the patient presented, for the treatment of NF there is a need for broad-spectrum antibiotic therapy associated with surgical debridement, use of activated charcoal for antiseptic compression and general intensive care.


Assuntos
Antibacterianos/uso terapêutico , Anti-Infecciosos Locais/uso terapêutico , Fasciite Necrosante/terapia , Adulto , Desbridamento , Fasciite Necrosante/complicações , Humanos , Hospedeiro Imunocomprometido , Masculino , Transtornos Relacionados ao Uso de Substâncias/complicações
14.
Implant Dent ; 27(4): 461-466, 2018 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-29864050

RESUMO

PURPOSE: The association of doxycycline (DOX) and autogenous bone on repair of critical-size defects was evaluated. MATERIALS AND METHODS: Fifty albino rats were divided into 5 groups (n = 10). A 5-mm diameter defect was treated with: control (CO)-blood clot; DOX in Natrosol (NAT)-10% gel; NAT-gel; particulate autogenous bone (PAB); and PAB + DOX - PAB associated with 10% DOX gel. The animals were euthanized at 4 and 8 weeks postoperatively. Histomorphometric analysis was performed to assess the percentage of new bone in the defect area. Statistical analysis of the results was performed using analysis of variance and the Tukey test (P < 0.05). RESULTS: The results showed that new bone formation was limited to the margins of the defect. At 4 and 8 weeks, the group PAB + DOX showed higher bone formation (38.59% and 47.86%, respectively), with statistical difference in comparison with the CO (19.52%) at 4 weeks and CO (18.80%), DOX (22.05%), and NAT (15.89%) at 8 weeks (P < 0.05). CONCLUSIONS: The association of 10% DOX with autogenous bone significantly improved bone healing in critical-size defects.


Assuntos
Regeneração Óssea/fisiologia , Transplante Ósseo/métodos , Doxiciclina/farmacologia , Crânio/cirurgia , Animais , Géis , Masculino , Ratos , Retalhos Cirúrgicos , Cicatrização/fisiologia
15.
J Craniofac Surg ; 29(6): 1578-1582, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-29742566

RESUMO

OBJECTIVE: To evaluate the effect of reusing drills and piezosurgery tips during implant osteotomy on immediate bone cell viability through immunohistochemical analysis. MATERIALS AND METHODS: Six male rabbits were divided into 2 groups and then divided into 5 subgroups-correspond to drills and tips used 10, 20, 30, 40, and 50 times, respectively. All animals received 10 osteotomies in each tibia, by use of the classic drilling procedure in one group (G1) and the piezosurgery device in the other group (G2). For immunohistochemical technique were utilized the osteoprotegerin, RANKL, osteocalcin, and caspase 3. Control procedures were performed by omitting the primary antibodies (negative control). RESULTS: Bone formation and resorption responses presented in more intense way during the piezosurgery. The expression of osteocalcin had become quite intense in piezosurgery groups, but with reduced immunostaining from the 30th osteotomy. The caspase 3 showed the viability of the osteoblast from the 20th osteotomy with piezosurgery and remained constant until the 50th. CONCLUSION: Piezosurgery provides greater osteoblastic cell viability than the system of conventional drilling. CLINICAL RELEVANCE: This study will provide data so that the authors can recycle the drills and tips for implant placement, thus enabling a better cell viability for osseointegration.


Assuntos
Osso e Ossos , Sobrevivência Celular/fisiologia , Osseointegração/fisiologia , Osteoblastos/fisiologia , Osteotomia/métodos , Piezocirurgia/métodos , Animais , Osso e Ossos/fisiologia , Osso e Ossos/cirurgia , Implantação Dentária Endo-Óssea/métodos , Imuno-Histoquímica , Masculino , Osteocalcina/metabolismo , Coelhos , Tíbia/cirurgia
16.
J Craniofac Surg ; 29(4): 975, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29481496

RESUMO

The frequency of accidents due to dog bite in children is high, and in the most cases, the child already knows the aggressor dog. Patient, 3 years, female, melanoderm, victim of pet dog attack on the right side of the face region. After the physical examination, conscious sedation was performed with the supplementation of oxygen by pediatrics and the suture by oral and maxillofacial surgeon, under local anesthesia with adrenergic vasoconstrictor, with internal points in the muscles using vicryl 4-0 and in the skin with 5-0 nylon; the lesser number of stitches were performed in the lower region of the wound, allowing spontaneous drainage spaces. The immediate wounds closure of dog bites on the face is safe, even in cases after several hours of the injury.


Assuntos
Mordeduras e Picadas/cirurgia , Face/cirurgia , Traumatismos Faciais/cirurgia , Suturas , Animais , Pré-Escolar , Cães , Feminino , Humanos
17.
J Appl Oral Sci ; 26: e20160645, 2018 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-29340482

RESUMO

Clear cell odontogenic carcinoma (CCOC) is a rare odontogenic tumor of the jaws, histologically characterized by the presence of agglomerates of cells with eosinophilic cytoplasm. The patient, a 62-year-old Caucasian woman, presented an intraosseous lesion in the mandibular symphysis. A clinical examination revealed a discrete volumetric increase with a hard consistency, palpable to extraoral and intraoral examinations. Imaging studies revealed an extensive radiolucent area, without defined limits, extending from the region of the right second premolar to the left canine. Incisional biopsy analysis indicated a diagnosis of CCOC. The treatment proposed was segmental resection of the mandible with a safety margin. After six months without recurrence, definitive mandibular reconstruction was performed using an iliac crest graft, followed by rehabilitation with implant-supported denture after five months. After three years of post-resection follow-up, the patient has shown no evidence of recurrence or metastasis. She continues to be under follow-up. To conclude, CCOC must be considered a malignant tumor with aggressive behavior. Previous studies have shown that resection with free margins is a treatment with a lower rate of recurrence. Nevertheless, long-term follow-up is necessary for such patients.


Assuntos
Adenocarcinoma de Células Claras/cirurgia , Neoplasias Mandibulares/cirurgia , Tumores Odontogênicos/cirurgia , Adenocarcinoma de Células Claras/diagnóstico por imagem , Adenocarcinoma de Células Claras/patologia , Biópsia , Transplante Ósseo/métodos , Feminino , Humanos , Ílio/transplante , Neoplasias Mandibulares/diagnóstico por imagem , Neoplasias Mandibulares/patologia , Osteotomia Mandibular/métodos , Pessoa de Meia-Idade , Tumores Odontogênicos/diagnóstico por imagem , Tumores Odontogênicos/patologia , Radiografia Panorâmica , Resultado do Tratamento
18.
J. appl. oral sci ; 26: e20170470, 2018. graf
Artigo em Inglês | LILACS-Express | ID: biblio-954503

RESUMO

Abstract The hypothesis of this study was that the peri-implant bone healing of the group of pinealectomized rats would differ from the control group. The samples were subjected to immunohistochemical, microtomographic (total porosity and connectivity density), and fluorochrome (mineralized surface) analyses. Objectives The goal of this study was to investigate the cellular changes and bone remodeling dynamics along the bone/implant interface in pinealectomized rats. Material and Methods The total of 18 adult male rats (Rattus norvegicus albinus, Wistar) was divided into three groups (n=6): control (CO), pinealectomized without melatonin (PNX) and pinealectomized with melatonin (PNXm). All animals were submitted to the first surgery (pinealectomy), except the CO group. Thirty days after the pinealectomy without melatonin, the second surgery was conducted, in which all animals received an implant in each tibia (36 titanium implants with surface treatment were installed - Implalife® São Paulo, SP, Brazil). By gavage, the rats of the PNX group received the vehicle solution, and the procedure. Results Immunohistochemical analysis for runt-related transcription factor 2 (RUNX2), alkaline phosphatase (ALP), osteopontin (OP) and osteocalcin (OC) showed that the bone repair process in the PNXm group was similar to that of the CO group, whereas the PNX group showed a delay. The microtomographic parameters of total porosity [Po(tot)] and bone surface (BS) showed no statistically significant differences, whereas for the connective density (Conn.Dn) a statistical difference was found between the CO and PNXm groups. Fluorochrome analysis of the active mineralized surface showed statistically significant difference between the CO and PNX and between the CO and PNXm groups. Conclusion The absence of the pineal gland impaired the bone repair process during osseointegration, however the daily melatonin replacement was able to restore this response.

19.
J. appl. oral sci ; 26: e20160645, 2018. graf
Artigo em Inglês | LILACS-Express | ID: biblio-893726

RESUMO

Abstract Clear cell odontogenic carcinoma (CCOC) is a rare odontogenic tumor of the jaws, histologically characterized by the presence of agglomerates of cells with eosinophilic cytoplasm. The patient, a 62-year-old Caucasian woman, presented an intraosseous lesion in the mandibular symphysis. A clinical examination revealed a discrete volumetric increase with a hard consistency, palpable to extraoral and intraoral examinations. Imaging studies revealed an extensive radiolucent area, without defined limits, extending from the region of the right second premolar to the left canine. Incisional biopsy analysis indicated a diagnosis of CCOC. The treatment proposed was segmental resection of the mandible with a safety margin. After six months without recurrence, definitive mandibular reconstruction was performed using an iliac crest graft, followed by rehabilitation with implant-supported denture after five months. After three years of post-resection follow-up, the patient has shown no evidence of recurrence or metastasis. She continues to be under follow-up. To conclude, CCOC must be considered a malignant tumor with aggressive behavior. Previous studies have shown that resection with free margins is a treatment with a lower rate of recurrence. Nevertheless, long-term follow-up is necessary for such patients.

20.
J Lasers Med Sci ; 8(4): 201-203, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-29071028

RESUMO

Case Presentation: This study aimed to report a case of medication related osteonecrosis of the jaw (MRONJ) of a 65-year-old female patient referred to the Oral and Maxillofacial Surgery team from Araçatuba Dental School, complaining about mobility of a previously dental implant placed on the posterior maxillary region. Clinical examination revealed an extensive necrosis area around the implant region. The patient reported bisphosphonate therapy with sodium alendronate for prevention of osteoporosis 5 years ago. A diagnosis of MRONJ was reached and the treatment decided was to remove the dental implant damaged and use the lower-level laser therapy (LLLT) associated with antibiotic therapy with clindamycin 300 mg and mouth rinses with chlorhexidine 0.12%. Conclusion: Six months after the treatment with LLLT a complete healing of the affected area was observed and 12 months after treatment the patient was rehabilitated with fixed dental prosthesis and showed excellent tissue healing of the necrosis areas. It was concluded that the use of LLLT showed to be a good option in the treatment of MRONJ.

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