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1.
In. Avezum, Alvaro; Pinto, Ibraim Masciarelli Francisco; Ferreira, João Fernando Monteiro; Izar, Maria Cristina de Oliveira. SOCESP - Cardiologia: atualização e reciclagem. São Paulo, Atheneu, 2017. p.369-373.
Monografia em Português | Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: ses-35643
2.
Arq Bras Cardiol ; 104(6): 443-9, 2015 Jun.
Artigo em Inglês, Português | MEDLINE | ID: mdl-26131699

RESUMO

BACKGROUND: The aging process promotes a progressive increase in chronic-degenerative diseases. The effect of these diseases on the functional capacity has been well recognized. Another health parameter concerns "quality of life related to health". Among the elderly population, cardiovascular diseases stand out due to the epidemiological and clinical impact. Usually, these diseases have been associated with others. This set of problems may compromise both independence and quality of life in elderly patients who seek cardiologic treatment. These health parameters have not been well contemplated by cardiologists. OBJECTIVE: Evaluating, among the elderly population with cardiovascular disease, which are the most relevant clinical determinants regarding dependence and quality of life. METHODS: This group was randomly and consecutively selected and four questionnaires were applied: HAQ, SF-36, PRIME-MD e Mini Mental State. RESULTS: The study included 1,020 elderly patients, 63.3% women. The group had been between 60 and 97 years-old (mean: 75.56 ± 6.62 years-old). 61.4% were independent or mild dependence. The quality of life total score was high (HAQ: 88.66 ± 2.68). 87.8% of patients had a SF-36 total score > 66. In the multivariate analysis, the association between diagnoses and high degrees of dependence was significant only for previous stroke (p = 0.014), obesity (p < 0.001), lack of physical activity (p = 0.016), osteoarthritis (p < 0.001), cognitive impairment (p < 0.001), and major depression (p < 0.001). Analyzing the quality of life, major depression and physical illness for depression was significantly associated with all domains of the SF-36. CONCLUSION: Among an elderly outpatient cardiology population, dependence and quality of life clinical determinants are not cardiovascular comorbidities, especially the depression.


Assuntos
Doenças Cardiovasculares/psicologia , Transtorno Depressivo/psicologia , Qualidade de Vida/psicologia , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Brasil/epidemiologia , Doenças Cardiovasculares/epidemiologia , Comorbidade , Transtorno Depressivo/epidemiologia , Métodos Epidemiológicos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Atividade Motora , Valores de Referência , Índice de Gravidade de Doença
3.
Arq. bras. cardiol ; 104(6): 443-449, 06/2015. tab
Artigo em Inglês | LILACS | ID: lil-750700

RESUMO

Background: The aging process promotes a progressive increase in chronic-degenerative diseases. The effect of these diseases on the functional capacity has been well recognized. Another health parameter concerns “quality of life related to health”. Among the elderly population, cardiovascular diseases stand out due to the epidemiological and clinical impact. Usually, these diseases have been associated with others. This set of problems may compromise both independence and quality of life in elderly patients who seek cardiologic treatment. These health parameters have not been well contemplated by cardiologists. Objective: Evaluating, among the elderly population with cardiovascular disease, which are the most relevant clinical determinants regarding dependence and quality of life. Methods: This group was randomly and consecutively selected and four questionnaires were applied: HAQ, SF-36, PRIME-MD e Mini Mental State. Results: The study included 1,020 elderly patients, 63.3% women. The group had been between 60 and 97 years-old (mean: 75.56 ± 6.62 years-old). 61.4% were independent or mild dependence. The quality of life total score was high (HAQ: 88.66 ± 2.68). 87.8% of patients had a SF-36 total score > 66. In the multivariate analysis, the association between diagnoses and high degrees of dependence was significant only for previous stroke (p = 0.014), obesity (p < 0.001), lack of physical activity (p = 0.016), osteoarthritis (p < 0.001), cognitive impairment (p < 0.001), and major depression (p < 0.001). Analyzing the quality of life, major depression and physical illness for depression was significantly associated with all domains of the SF-36. Conclusion: Among an elderly outpatient cardiology population, dependence and quality of life clinical determinants are not cardiovascular comorbidities, especially the depression. .


Fundamento: Com o envelhecimento, a prevalência de doenças crônico-degenerativas sofreu aumento progressivo. A repercussão dessas doenças sobre a capacidade funcional foi reconhecida. Outro parâmetro de saúde é a “qualidade de vida relacionada à saúde”. Na população idosa, as doenças cardiovasculares destacam-se pelo impacto epidemiológico e clínico. Elas, geralmente, vêm associadas a outras afecções. Esse conjunto de problemas pode comprometer a independência e a qualidade de vida do idoso que busca tratamento cardiológico. Objetivo: Avaliar, em uma população de idosos cardiopatas, quais são os determinantes clínicos mais relevantes de dependência e de qualidade de vida. Métodos: O grupo foi selecionado aleatória e consecutivamente, sendo aplicados quatro questionários: HAQ, SF-36, PRIME‑MD e Mini Exame do Estado Mental. Resultados: Incluiu-se 1020 idosos, 63,3% mulheres. O grupo tinha em média 75,56 ± 6,62 anos. 61,4% mostrou-se independente ou com dependência leve. O escore de qualidade de vida foi elevado (HAQ: 88,66 ± 2,68). 87,8% dos pacientes apresentou escore total do SF-36 ≥ 66. À análise multivariada, a associação entre os diagnósticos e graus elevados de dependência foi significante apenas para acidente vascular cerebral prévio (p = 0,014), obesidade (p < 0,001), sedentarismo (p = 0,016), osteoartrite (p < 0,001), déficit cognitivo (p < 0,001), e depressão maior (p < 0,001). Ao analisarmos a qualidade de vida, a depressão maior e a depressão por doença física associou-se significativamente com todos os domínios do SF-36. Conclusão: Em uma população de idosos cardiopatas, os determinantes clínicos mais relevantes de prejuízos para dependência e qualidade de vida foram as comorbidades não cardiovasculares, particularmente a depressão. .


Assuntos
Humanos , Hepatócitos/patologia , Regeneração Hepática , Falência Hepática Aguda/metabolismo , Apoptose , /fisiologia , Proteína Ligante Fas/fisiologia , Hepatócitos/metabolismo , Falência Hepática Aguda/terapia , Necrose , Receptores do Fator de Necrose Tumoral/metabolismo , Transdução de Sinais , Ligante Indutor de Apoptose Relacionado a TNF/fisiologia , Fator de Necrose Tumoral alfa/metabolismo
4.
Clinics (Sao Paulo) ; 67(4): 305-11, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22522754

RESUMO

OBJECTIVES: Though elderly persons with chronic atrial fibrillation have more comorbidities that could limit indications for the chronic use of anticoagulants, few studies have focused on the risk of falls within this particular group. To evaluate the predictors of the risk of falls among elderly with chronic atrial fibrillation, a cross-sectional, observational study was performed. METHODS: From 295 consecutive patients aged 60 years or older with a history of atrial fibrillation who were enrolled within the last 2 years in the cardiogeriatrics outpatient clinic of the Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, 107 took part in this study. Their age was 77.9±6.4 years, and 62 were female. They were divided into two groups: a) no history of falls in the previous year and b) a history of one or more falls in the previous year. Data regarding the history of falls and social, demographic, anthropometric, and clinical information were collected. Multidimensional assessment instruments and questionnaires were applied. RESULTS: At least one fall was reported in 55 patients (51.4%). Among them, 27 (49.1%) presented recurrent falls, with body lesions in 90.4% and fractures in 9.1% of the cases. Multivariate logistic regression showed that self-reported difficulty maintaining balance, use of amiodarone, and diabetes were independent variables associated with the risk of falls, with a sensitivity of 92.9% and a specificity of 44.9%. CONCLUSION: In a group of elderly patients with chronic atrial fibrillation who were relatively independent and able to attend an outpatient clinic, the occurrence of falls with recurrence and clinical consequences was high. Difficulty maintaining balance, the use of amiodarone and a diagnosis of diabetes mellitus were independent predictors of the risk for falls. Thus, simple clinical data predicted falls better than objective functional tests.


Assuntos
Acidentes por Quedas/estatística & dados numéricos , Anticoagulantes/uso terapêutico , Fibrilação Atrial/complicações , Acidente Vascular Cerebral/prevenção & controle , Idoso , Anticoagulantes/efeitos adversos , Doença Crônica , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Recidiva , Medição de Risco , Fatores de Risco
5.
In. Timerman, Ari; Bertolami, Marcelo; Ferreira, João Fernando Monteiro. Manual de Cardiologia. São Paulo, Atheneu, 2012. p.1041-1048, tab, graf.
Monografia em Português | Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: ses-26935
6.
Clinics ; 67(4): 305-311, 2012. ilus, tab
Artigo em Inglês | LILACS | ID: lil-623108

RESUMO

OBJECTIVES: Though elderly persons with chronic atrial fibrillation have more comorbidities that could limit indications for the chronic use of anticoagulants, few studies have focused on the risk of falls within this particular group. To evaluate the predictors of the risk of falls among elderly with chronic atrial fibrillation, a cross-sectional, observational study was performed. METHODS: From 295 consecutive patients aged 60 years or older with a history of atrial fibrillation who were enrolled within the last 2 years in the cardiogeriatrics outpatient clinic of the Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, 107 took part in this study. Their age was 77.9±6.4 years, and 62 were female. They were divided into two groups: a) no history of falls in the previous year and b) a history of one or more falls in the previous year. Data regarding the history of falls and social, demographic, anthropometric, and clinical information were collected. Multidimensional assessment instruments and questionnaires were applied. RESULTS: At least one fall was reported in 55 patients (51.4%). Among them, 27 (49.1%) presented recurrent falls, with body lesions in 90.4% and fractures in 9.1% of the cases. Multivariate logistic regression showed that selfreported difficulty maintaining balance, use of amiodarone, and diabetes were independent variables associated with the risk of falls, with a sensitivity of 92.9% and a specificity of 44.9%. CONCLUSION: In a group of elderly patients with chronic atrial fibrillation who were relatively independent and able to attend an outpatient clinic, the occurrence of falls with recurrence and clinical consequences was high. Difficulty maintaining balance, the use of amiodarone and a diagnosis of diabetes mellitus were independent predictors of the risk for falls. Thus, simple clinical data predicted falls better than objective functional tests.


Assuntos
Idoso , Feminino , Humanos , Pessoa de Meia-Idade , Acidentes por Quedas/estatística & dados numéricos , Anticoagulantes/uso terapêutico , Fibrilação Atrial/complicações , Acidente Vascular Cerebral/prevenção & controle , Anticoagulantes/efeitos adversos , Doença Crônica , Estudos Transversais , Recidiva , Medição de Risco , Fatores de Risco
9.
Rev. bras. ter. intensiva ; 19(3): 317-321, jul.-set. 2007. ilus, graf
Artigo em Português | LILACS | ID: lil-470941

RESUMO

JUSTIFICATIVA E OBJETIVOS: A pressão do balonete transmitida diretamente na parede da traquéia de forma irregular pode ocasionar lesões e levar a broncoaspiração. O objetivo deste estudo foi demonstrar que ao implantar uma rotina de mensuração da pressão do balonete, obtém-se controle fidedigno para manter as medidas dentro dos parâmetros considerados seguros, evitando assim, as complicações descritas. MÉTODO: Foram avaliadas 3195 medidas de pressão de balonete em 1194 pacientes dos sexos masculino e feminino, internados nas unidades de terapia intensiva (UTI) e coronariana (UC), que estavam sob ventilação mecânica com uso de prótese endotraqueal e cânula de traqueostomia, nos períodos matutino e vespertino. RESULTADOS: Durante o período de março a agosto de 2005 foi realizado acompanhamento das medidas colhidas pelos profissionais de fisioterapia e observou-se que as medidas foram irregulares, em média, em 80 por cento dos casos. Diante desse fato foi elaborado um programa de treinamento, com foco nas Equipes de Enfermagem das UTI e UC, que consistiu na orientação dos procedimentos adequados realizados à beira do leito (treinamento em loco). Os treinamentos foram realizados em dois períodos (matutino e vespertino) para abranger toda a equipe. CONCLUSÕES: Sugere-se a necessidade da vigilância das pressões do balonete através da implantação de uma rotina de mensurações matutina, vespertina e noturna, como meio profilático, para prevenir as possíveis complicações da pressão de balão da prótese traqueal.


BACKGROUND AND OBJECTIVES: The tube cuff pressure directly transmitted on the tracheal wall in an irregular form can cause injuries and lead to bronchoaspiration. The aim of this study was to demonstrate that the implementation of routine tube cuff pressure measurements result in a reliable control to maintain the measurements within the parameters considered safe, thus preventing the described complications. METHODS: A total of 3,195 tube cuff measurements were obtained from 1,194 male and female patients admitted at the Intensive Care Unit (ICU) and Coronary Unit (CU), who were undergoing mechanical ventilation with endotracheal prosthesis and tracheotomy cannula, during the morning and afternoon periods. RESULTS: From March to August 2005 the follow-up of the measurements obtained by the physical therapy professionals was carried out and it was observed that the measurements were irregular, on average, in 80 percent of the cases. Thus, a training program was established, which was focused on the Nursing Teams of the ICU and CU, consisting in providing directions for the adequate procedures performed at the bedside (in loco training). The training procedures were carried out at two different periods (morning and afternoon) in order to include the whole team. CONCLUSIONS: It is suggested that it is necessary to monitor tube cuff pressure through the implementation of routine measurements in the morning, afternoon and evening periods as a prophylactic measure, in order to prevent the possible complications of tracheal prosthesis balloon pressure.


Assuntos
Humanos , Masculino , Feminino , História do Século XXI , Intubação Intratraqueal , Traqueostomia
10.
Rev. bras. ter. intensiva ; 19(1): 31-37, jan.-mar. 2007. ilus, graf, tab
Artigo em Português | LILACS | ID: lil-466766

RESUMO

JUSTIFICATIVA E OBJETIVOS: A retirada precoce da ventilação mecânica dos pacientes das unidades de terapia intensiva (UTI) é importante para a redução da morbimortalidade, porém na prática, os desmames são realizados aleatoriamente. Face à importância desse procedimento, esse estudo avaliou a implementação de protocolos de desmame e comparou dois métodos distintos. MÉTODO: Foram incluídos no estudo 120 pacientes dependentes de ventilação mecânica por mais de 48 horas. O método de Pressão Suporte + PEEP (PSP), foi aplicado aos pacientes em dias pares, constituindo o grupo 1 (GPSP) e em dias ímpares, utilizou-se o método do Tubo-T (TT), formando o grupo 2 (GTT), RESULTADOS: A resposta dos pacientes à extubação revelou evolução semelhante nos dois grupos, porém deixou claro, pela análise estatística do teste Qui-quadrado, o benefício de se utilizar um protocolo de desmame. De todos os pacientes estudados, 109 (90,83 por cento) tiveram sucesso na extubação não sendo necessário nenhum tipo de ventilação não-invasiva dentro de 24 horas após o desmame, enquanto que apenas 11 pacientes (9,17 por cento) necessitaram de ventilação mecânica não-invasiva ou de re-intubação no mesmo período, caracterizando o insucesso do desmame. CONCLUSÕES: A implementação e a padronização de protocolos de desmame da ventilação mecânica, reduziu significativamente o índice de re-intubação na UTI, diminuindo o período de internação e o índice de morbimortalidade, porém neste estudo, não foram encontradas diferenças estatísticas significativas entre os métodos analisados.


BACKGROUND AND OBJECTIVES: Mechanical ventilation incurs significant morbidity and mortality, weaning intensive care unit patients is highly desirable, although it is usuallyconducted in an empirical manner. Thus, this article assessed a weaning protocol implementation and compared two different methods. METHODS: It was carried out a study involving 120 patients who had received mechanical ventilation for more than 48 hours. These patients were randomlyassigned to undergo one of two weaning techniques: pressure-supportventilation + PEEP (PSP) technique, which was applied to the patients in equal days, forming the PSP group (PSPG) and the T-tube method (TT), applied in odd days and forming the TT group (TTG). Standardized protocols were followedfor each technique RESULTS: The patients response to extubation revealed similar progress in both PSP and TT groups, but after the Chi-square statistical test, the benefits of using a weaning protocol was clear. One hundred nine (90.83 percent) of all patients, had a successful weaning and any noninvasive ventilation type was needed in a span time of 24 hours after extubation, and only eleven (9.17 percent), had an unsuccessful weaning. CONCLUSIONS: Although this study didn't show any difference between the two methods applied, we could conclude that, the implementation of standardized weaning protocols can substantially decrease the patient's reintubation rate, promoting a downward trend in mortality and morbidity for these patients and shortening their hospital and intensive care units length of stay.


Assuntos
Humanos , Masculino , Feminino , Desmame do Respirador/instrumentação , Desmame do Respirador/métodos , Desmame do Respirador/normas , Desmame do Respirador
11.
Rev Bras Ter Intensiva ; 19(3): 317-21, 2007 Sep.
Artigo em Português | MEDLINE | ID: mdl-25310065

RESUMO

BACKGROUND AND OBJECTIVES: The tube cuff pressure directly transmitted on the tracheal wall in an irregular form can cause injuries and lead to bronchoaspiration. The aim of this study was to demonstrate that the implementation of routine tube cuff pressure measurements result in a reliable control to maintain the measurements within the parameters considered safe, thus preventing the described complications. METHODS: A total of 3,195 tube cuff measurements were obtained from 1,194 male and female patients admitted at the Intensive Care Unit (ICU) and Coronary Unit (CU), who were undergoing mechanical ventilation with endotracheal prosthesis and tracheotomy cannula, during the morning and afternoon periods. RESULTS: From March to August 2005 the follow-up of the measurements obtained by the physical therapy professionals was carried out and it was observed that the measurements were irregular, on average, in 80% of the cases. Thus, a training program was established, which was focused on the Nursing Teams of the ICU and CU, consisting in providing directions for the adequate procedures performed at the bedside (in loco training). The training procedures were carried out at two different periods (morning and afternoon) in order to include the whole team. CONCLUSIONS: It is suggested that it is necessary to monitor tube cuff pressure through the implementation of routine measurements in the morning, afternoon and evening periods as a prophylactic measure, in order to prevent the possible complications of tracheal prosthesis balloon pressure.

12.
Rev Bras Ter Intensiva ; 19(1): 31-7, 2007 Mar.
Artigo em Português | MEDLINE | ID: mdl-25310657

RESUMO

BACKGROUND AND OBJECTIVES: Mechanical ventilation incurs significant morbidity and mortality, weaning intensive care unit patients is highly desirable, although it is usuallyconducted in an empirical manner. Thus, this article assessed a weaning protocol implementation and compared two different methods. METHODS: It was carried out a study involving 120 patients who had received mechanical ventilation for more than 48 hours. These patients were randomlyassigned to undergo one of two weaning techniques: pressure-supportventilation + PEEP (PSP) technique, which was applied to the patients in equal days, forming the PSP group (PSPG) and the T-tube method (TT), applied in odd days and forming the TT group (TTG). Standardized protocols were followedfor each technique RESULTS: The patients response to extubation revealed similar progress in both PSP and TT groups, but after the Chi-square statistical test, the benefits of using a weaning protocol was clear. One hundred nine (90.83%) of all patients, had a successful weaning and any noninvasive ventilation type was needed in a span time of 24 hours after extubation, and only eleven (9.17%), had an unsuccessful weaning. CONCLUSIONS: Although this study didn't show any difference between the two methods applied, we could conclude that, the implementation of standardized weaning protocols can substantially decrease the patient's reintubation rate, promoting a downward trend in mortality and morbidity for these patients and shortening their hospital and intensive care units length of stay.

13.
Gynecol Endocrinol ; 20(4): 213-20, 2005 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-16019364

RESUMO

The digitalics (digoxin and digitoxin) have an estrogenic action, confirmed by the presence of gynecomastia observed in men who are users of steroids, and it is also confirmed by the increase of vaginal trophism in postmenopausal female users, although little is known about the endometrium. These effects might result from the similarity of the chemical structures between the digitalics and estrogens. This study evaluated 27 female mice. Twenty-four mice were oophorectomized and in three of them the ovaries were manipulated, but they were not extirpated. Forty days after the surgery each group of three animals received a medication with a specific drug (digoxin, digitoxin or estradiol) for 2 weeks. Twenty-four hours after the last medication, all the animals were hysterectomized and the wombs were processed, cut and put on laminae. By histomorphometry, we analysed the area of the transverse sections of the endometrium, the area of the endometrial glands and the height of the uterine epithelium. The respective averages and the standard deviations were calculated. The results showed that digoxin neither presented an estrogenic action (p > 0.05) nor raised the power of the estradiol action (p > 0.05). Digitoxin promoted an estrogenic action on the glandular area (p < 0.05), and also raised the power of the estradiol action on the transverse section of the endometrium and on the glandular area (p < 0.05).


Assuntos
Antiarrítmicos/farmacologia , Digitoxina/farmacologia , Digoxina/farmacologia , Endométrio/efeitos dos fármacos , Estradiol/farmacologia , Animais , Endométrio/patologia , Feminino , Histocitoquímica , Processamento de Imagem Assistida por Computador , Camundongos , Ovariectomia , Distribuição Aleatória
14.
Rev. SOCERJ ; 18(1): 77-81, Jan-Mar. 2005. tab
Artigo em Português | LILACS | ID: lil-407481

RESUMO

Objetivo: Dados encontrados na literatura sugerem que a terapia de reposição hormonal (TRH) pode promover alteração de repolarização e taquicardia ventricular. Como consequência houve um interesse na terapia com raloxifeno (R), um modulador seletivo do receptor do estrogênio, em função do seu potencial em apresentar a maioria dos efeitos benefícios do estrogênio, enquanto evita a maioria dos seus efeitos adversos.Métodos: Este estudo randomizado, duplo-cego e cruzado teve o objetivo de comparar o efeito do R com o TRH, no intervalo QT no eletrocardiograma, em 30 mulheres hipertensas, com idade média de 69 anos após um período run-in com hidroclorothiazida 12,5 mg uma vez ao dia. O intervalo QT foi corrigido(QTc) para a frequência cardíaca e a dispersão do QT(QTd) foi definida como a diferença entre os intervalos QT máximo e mínimo em quaisquer 2 derivações. As medidas foram realizadas no período basal, após 8 semanas de TRH (estradiol transdérmico+noretisterona) e após 8 semanas de R (60mg), com um período de wash-out entre as duas terapias.Resultados: verificou-se que R e TRH aumentaram QTc numa mesma extensão quando comparado aos níveis basais (p menor 0,05), embora não haja diferença significativa entre eles apesar dos valores de QTd.Conclusão: Os resultados encontrados neste estudo sugerem que o R e o TRH exercem os mesmos efeitos no intervalo QTc em mulheres hipertensas, em pós menopausa, não demonstrando qualquer efeito no QTd. Tal resultado deve encorajar futuros estudos para avaliar o impacto em eventos clínicos


Assuntos
Feminino , Idoso , Pressão Arterial/fisiologia , Cloridrato de Raloxifeno/farmacologia , Cloridrato de Raloxifeno/síntese química , Cloridrato de Raloxifeno/uso terapêutico , Terapia de Reposição Hormonal/métodos , Terapia de Reposição Hormonal/tendências , Terapia de Reposição Hormonal , Menopausa/fisiologia
15.
In. Aldrighi, José Mendes; Faludi, André Arpadi; Mansur, Antonio de Pádua; Aldrighi, José Mendes, d. Universidade de São Paulo. BrasilFaludi, André Arpadi, d. Instituto dante Pazzanese de Cardiologia. BrasilMansur, Antonio de Pádua, d. Universidade de São Paulo. Brasil. Doença cardiovascular no climatério. São Paulo, Atheneu, 200500002005. p.87-102, ilus. (BR).
Monografia em Português | Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: ses-5122
17.
Rev. Soc. Cardiol. Estado de Säo Paulo ; 14(6): 971-981, nov.-dez. 2004. ilus, tab
Artigo em Português | LILACS | ID: lil-413912

RESUMO

O impacto epidemiológico do infarto agudo do miocárdio com supradesnivelamento do segmento ST é enorme. Desse modo, é fundamental reconhecer o quadro, diagnóstica-lo e trata-lo com agilidade e eficiência. Idosos e mulheres já foram considerados, em publicações e diretrizes, grupos especiais. Obviamente não podemos considerar mais de 60 por cento dos pacientes infartados como tal. Neste artigo, é feita uma revisão de aspectos peculiares do comportamento de idosos e mulheres que sofrem infarto agudo do miocárdio com supradesnivelamento de ST.


Assuntos
Humanos , Masculino , Feminino , Idoso , Doenças Cardiovasculares/mortalidade , Infarto do Miocárdio/complicações , Infarto do Miocárdio/diagnóstico , Infarto do Miocárdio/mortalidade , Aspirina/uso terapêutico , Heparina/uso terapêutico
18.
Am J Cardiol ; 94(11): 1453-6, 2004 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-15566926

RESUMO

The administration of oral raloxifene in 30 postmenopausal hypertensive women was evaluated to demonstrate its effect on arterial stiffness. Casual and ambulatory blood pressure (BP) and pulse-wave velocity (PWV) data were obtained before and after patients received raloxifene, estrogen-progestin replacement therapy, or placebo in a randomized crossover study. It was shown that the 2 therapies decreased BP and carotid-femoral PWV, and the effect of raloxifene on vascular compliance was independent of the effects on BP.


Assuntos
Pressão Sanguínea/efeitos dos fármacos , Terapia de Reposição de Estrogênios , Hipertensão/tratamento farmacológico , Cloridrato de Raloxifeno/farmacologia , Cloridrato de Raloxifeno/uso terapêutico , Moduladores Seletivos de Receptor Estrogênico/farmacologia , Moduladores Seletivos de Receptor Estrogênico/uso terapêutico , Administração Oral , Idoso , Monitorização Ambulatorial da Pressão Arterial , Estudos Cross-Over , Feminino , Humanos , Pós-Menopausa , Resistência Vascular
20.
In. Luz, Protásio Lemos da; Laurindo, Francisco Rafael Martins; Chagas, Antônio Carlos Palandri. Endotélio e doenças cardiovasculares. São Paulo, Atheneu, 2003. p.281-295, ilus, tab.
Monografia em Português | LILACS | ID: lil-504071
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