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J Fam Pract ; 68(6): 334-340, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31381621


Failure to control these dermatologic changes can lead to lower dosages of cancer agents or an interrupted course of Tx. These steps can help you to head off trouble.

Pediatr Diabetes ; 12(1): 50-7, 2011 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-20456085


Type 2 diabetes in youth was almost unheard of only two decades ago. However, tracking the recent dramatic rise in childhood obesity, type 2 diabetes has become increasingly prevalent. Thus, there is an urgent need for high-quality clinical trials to increase in-depth knowledge about pathophysiology, optimal treatment, and prevention. We therefore systematically reviewed published and ongoing clinical trials of type 2 diabetes in children and adolescents. The results demonstrate that (i) few randomized clinical trials have been completed and published in children with type 2 diabetes; (ii) ongoing trials in type 1 diabetes clearly outnumber trials in type 2 diabetes; and (iii) recruitment and enrollment into the latter trials are challenging, however once achieved, drop-out rates are not excessively high. We conclude that type 2 diabetes in youth is an important but difficult new field of clinical research, and we discuss the existing barriers to successful recruitment, conduct, and support of these clinical trials.

Ensaios Clínicos como Assunto , Diabetes Mellitus Tipo 2/tratamento farmacológico , Adolescente , Criança , Humanos , Seleção de Pacientes , Fatores de Risco
Fertil Steril ; 94(5): 1627-31, 2010 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-19945097


OBJECTIVE: To assess the prevalence of patient-reported, physician-diagnosed comorbid conditions in women with endometriosis. DESIGN: Cross-sectional study of self-reported survey data. SETTING: Academic research. PATIENT(S): Four thousand three hundred thirty-one Endometriosis Association (EA) members reporting surgically diagnosed endometriosis. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Self-reported, physician-diagnosed infectious diseases, cancers, and endocrine diseases. RESULT(S): Nearly two-thirds of women reported one or more of the assessed conditions. Recurrent upper respiratory infections and recurrent vaginal infections were common and more likely in women responding to the EA survey. Melanoma was reported by 0.7% (n=29), breast cancer by 0.4% (n=16), and ovarian cancer by 0.2% (n=10). While ovarian cancer and melanoma were significantly more common than in the general population, breast cancer was surprisingly less common. Addison's disease and Cushing's syndrome were rare (0.2% and 0.1%, respectively). CONCLUSION(S): Respondents reported a higher prevalence of recurrent upper respiratory or vaginal infections, melanoma, and ovarian cancer than the general population. These findings document other potential associations related to the immune system, which may help focus future research into this disease.

Doenças do Sistema Endócrino/epidemiologia , Endometriose/epidemiologia , Melanoma/epidemiologia , Neoplasias Ovarianas/epidemiologia , Infecções Respiratórias/epidemiologia , Doenças Uterinas/epidemiologia , Doenças Vaginais/epidemiologia , Doença de Addison/epidemiologia , Adolescente , Adulto , Idoso , Comorbidade , Anormalidades Congênitas/epidemiologia , Estudos Transversais , Síndrome de Cushing/epidemiologia , Endometriose/cirurgia , Feminino , Humanos , Pessoa de Meia-Idade , Prolapso da Valva Mitral/epidemiologia , Prevalência , Recidiva , Autorrevelação , Neoplasias Cutâneas/epidemiologia , Doenças Uterinas/cirurgia , Adulto Jovem