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1.
Angew Chem Int Ed Engl ; 58(35): 12190-12194, 2019 Aug 26.
Artigo em Inglês | MEDLINE | ID: mdl-31250946

RESUMO

Highly enantioselective [3+3] and [3+4] annulations of isatin-derived enals with ethynylethylene carbonates and ethynyl benzoxazinanones are enabled by NHC/cooper cooperative catalysis, leading to a big library of spirooxindole derivatives in high structural diversity and enantioselectivity (up to 99 % ee). Both reactions represent a nicely synergistic integration of NHC and copper catalysis, in which both catalysts activate the substrates and the chiral NHC perfectly controls the stereochemistry.

2.
Org Lett ; 20(24): 7907-7911, 2018 12 21.
Artigo em Inglês | MEDLINE | ID: mdl-30540196

RESUMO

The first catalytic asymmetric decarboxylative [3 + 2] cycloaddition reaction of ethynylethylene carbonates with malononitrile has been developed successfully by an organo/copper cooperative system. This strategy led to a series of optically active polysubstituted dihydrofurans in good yields with high levels of enantioselectivities (up to 99% yield, 97% ee). The presence of the terminal alkynyl and the cyano group in the dihydrofuran products provides a wide scope for further structural transformations. More importantly, this organo/metal cooperative catalytic system will broaden the substrate scope and enable fundamentally new reactions.

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