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1.
PeerJ ; 5: e3739, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28890851

RESUMO

Chemical communication relating to predation risk is a trait common among fish species. Prey fish under threat of predation can signal risk to conspecific fish, which then exhibit defensive responses. Fish also assess predation risk by visual cues and change their behavior accordingly. Here, we explored whether these behavioral changes act as visual alarm signals to conspecific fish that are not initially under risk. We show that shoals of zebrafish (Danio rerio) visually exposed to a predator display antipredator behaviors. In addition, these defensive maneuvers trigger antipredator reactions in conspecifics and, concomitantly, stimulate the hypothalamus-pituitary-interrenal axis, leading to cortisol increase. Thus, we conclude that zebrafish defensive behaviors act as visual alarm cues that induce antipredator and stress response in conspecific fish.

2.
Sci Rep ; 6: 37612, 2016 11 22.
Artigo em Inglês | MEDLINE | ID: mdl-27874070

RESUMO

Here we provide, at least to our knowledge, the first evidence that aripiprazole (APPZ) in the water blunts the stress response of exposed fish in a concentration ten times lower than the concentration detected in the environment. Although the mechanism of APPZ in the neuroendocrine axis is not yet determined, our results highlight that the presence of APPZ residues in the environment may interfere with the stress responses in fish. Since an adequate stress response is crucial to restore fish homeostasis after stressors, fish with impaired stress response may have trouble to cope with natural and/or imposed stressors with consequences to their welfare and survival.


Assuntos
Aripiprazol/toxicidade , Estresse Fisiológico/efeitos dos fármacos , Poluentes Químicos da Água/toxicidade , Peixe-Zebra/fisiologia , Animais , Feminino , Hidrocortisona/metabolismo , Masculino
3.
Arch Environ Contam Toxicol ; 71(3): 415-22, 2016 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-27423874

RESUMO

In agriculture intensive areas, fishponds and natural water bodies located in close proximity to these fields receive water with variable amounts of agrichemicals. Consequently, toxic compounds reach nontarget organisms. For instance, aquatic organisms can be exposed to tebuconazole-based fungicides (TBF), glyphosate-based herbicides (GBH), and atrazine-based herbicides (ABH) that are potentially dangerous, which motivates the following question: Are these agrichemicals attractant or aversive to fish? To answer this question, adult zebrafish were tested in a chamber that allows fish to escape from or seek a lane of contaminated water. This attraction and aversion paradigm was evaluated with zebrafish in the presence of an acute contamination with these compounds. We showed that only GBH was aversive to fish, whereas ABH and TBF caused neither attraction nor aversion for zebrafish. Thus, these chemicals do not impose an extra toxic risk by being an attractant for fish, although TBF and ABH can be more deleterious, because they induce no aversive response. Because the uptake and bioaccumulation of chemicals in fish seems to be time- and dose-dependent, a fish that remains longer in the presence of these substances tends to absorb higher concentrations than one that escapes from contaminated sites.


Assuntos
Agroquímicos/toxicidade , Peixes/fisiologia , Poluentes Químicos da Água/toxicidade , Animais , Aprendizagem da Esquiva , Comportamento Animal , Testes de Toxicidade , Peixe-Zebra
4.
PLoS One ; 10(10): e0140800, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26473477

RESUMO

The presence of drugs and their metabolites in surface waters and municipal effluents has been reported in several studies, but its impacts on aquatic organisms are not yet well understood. This study investigated the effects of acute exposure to the antipsychotic risperidone on the stress and behavioral responses in zebrafish. It became clear that intermediate concentration of risperidone inhibited the hypothalamic-pituitary-interrenal axis and displayed anxiolytic-like effects in zebrafish. The data presented here suggest that the presence of this antipsychotic in aquatic environments can alter neuroendocrine and behavior profiles in zebrafish.


Assuntos
Ansiolíticos/efeitos adversos , Sistema Hipotálamo-Hipofisário/metabolismo , Sistema Hipófise-Suprarrenal/metabolismo , Risperidona/efeitos adversos , Poluentes Químicos da Água/efeitos adversos , Peixe-Zebra/metabolismo , Animais , Ansiolíticos/farmacologia , Comportamento Animal/efeitos dos fármacos , Sistema Hipotálamo-Hipofisário/patologia , Sistema Hipófise-Suprarrenal/patologia , Risperidona/farmacologia , Poluentes Químicos da Água/farmacologia
5.
PLoS One ; 9(7): e103232, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25054216

RESUMO

The presence of pharmaceutical products in the aquatic environment has been reported in several studies. However, the impact of these drugs on living organisms is still uncharacterized. Here, we investigated the effects of acute exposure to either diazepam or fluoxetine on the stress response in Danio rerio. We showed that diazepam and fluoxetine inhibited the stress axis in zebrafish. Intermediate concentrations of diazepam suppressed the stress response as measured by cortisol levels, whereas fluoxetine inhibited cortisol increase at concentrations similar to those found in the environment. These data suggest that the presence of psychoactive drugs in aquatic ecosystems could cause neuroendocrine dysfunction in fish.


Assuntos
Ansiolíticos/farmacologia , Antidepressivos de Segunda Geração/farmacologia , Diazepam/farmacologia , Fluoxetina/farmacologia , Estresse Fisiológico/efeitos dos fármacos , Poluentes Químicos da Água/farmacologia , Peixe-Zebra/fisiologia , Animais , Feminino , Masculino
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