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Neurosci Lett ; 650: 114-117, 2017 05 22.
Artigo em Inglês | MEDLINE | ID: mdl-28445770


Several studies have reported the presence of methylphenidate (MPH) in effluents; however, its impacts on aquatic life are not yet well understood. Here, we investigated the effects of acute exposure on endocrine and behavioral stress responses to environmentally relevant concentrations of MPH in zebrafish. We show that MPH blunts the response of cortisol to stress in zebrafish. On the other hand, MPH stresses fish per se. Additionally, MPH seems to modulate anxiety-like behaviors. We conclude that the presence of MPH in aquatic environments can alter neuroendocrine and behavior responses, which might considerably impact fish survival and welfare.

Comportamento Animal/efeitos dos fármacos , Comportamento Animal/fisiologia , Hidrocortisona/metabolismo , Metilfenidato/administração & dosagem , Estresse Fisiológico/efeitos dos fármacos , Poluentes Químicos da Água/administração & dosagem , Peixe-Zebra/fisiologia , Animais , Estimulantes do Sistema Nervoso Central/administração & dosagem , Relação Dose-Resposta a Droga , Sistema Endócrino/efeitos dos fármacos , Sistema Endócrino/fisiologia , Feminino , Humanos , Estresse Fisiológico/fisiologia
Fish Shellfish Immunol ; 30(1): 51-7, 2011 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-20883798


Using agrichemicals to control unwanted species has become a necessary and common worldwide practice to improve crop production. Although most currently used agrichemicals are considered relatively safe, continuous usage contributes for soil and water contamination and collateral toxic effects on aquatic species. Few studies correlated the presence of agrichemicals on fish blood cells and natural immune system. Thus, in this study, silver catfish (Rhamdia quelen) were exposed to sublethal concentrations (10% of the LC(50-96 h)) of a glyphosate based herbicide and hematological and natural immune system parameters were evaluated. Silver catfish fingerlings exposed to glyphosate for 96 h had a significant reduction on blood erythrocytes, thrombocytes, lymphocytes and total leukocytes in contrast to a significant increase in the number of immature circulating cells. The effect of glyphosate on natural immune system was evaluated after 24h or 10 days exposure by measuring the phagocytic index of coelomic cells, and lysozyme, total peroxidase, bacteria agglutination, bactericidal activity and natural complement hemolytic activity in the serum of fingerlings. A significant reduction on phagocytic index, serum bacteria agglutination and total peroxidase was observed only after 24h exposure to glyphosate. In contrast, fingerlings exposed to glyphosate for 10 days had a significant lower serum bacteria agglutination and lysozyme activity. Glyphosate had no effect on serum bactericidal and complement natural hemolytic activity after 24h or 10 days exposure. Nonetheless, the information obtained in this study indicates that glyphosate contaminated water contributes to alter blood cells parameters and to reduce the activity of natural immune components important to mediate fish resistance to infecting microorganisms.

Peixes-Gato , Doenças dos Peixes/induzido quimicamente , Glicina/análogos & derivados , Herbicidas/toxicidade , Poluentes Químicos da Água/toxicidade , Aeromonas , Animais , Ensaio de Atividade Hemolítica de Complemento/veterinária , Relação Dose-Resposta a Droga , Feminino , Doenças dos Peixes/sangue , Doenças dos Peixes/imunologia , Glicina/administração & dosagem , Glicina/toxicidade , Herbicidas/administração & dosagem , Masculino , Muramidase/sangue , Peroxidase/sangue , Fatores de Tempo