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1.
J Am Dent Assoc ; 151(4): 276-286, 2020 04.
Artigo em Inglês | MEDLINE | ID: mdl-32222176

RESUMO

BACKGROUND: The objective of this study was to compare the experience and distribution of tooth loss in people with and without diabetes. METHODS: The authors conducted a comparative cross-sectional study of patients at a public university. Analysis included medical records of those treated from 2013 through 2017. The dependent and main independent variables were the number of missing teeth and a diagnosis of diabetes, respectively. As covariables, the authors analyzed the sociodemographic and socioeconomic characteristics, as well as the general and oral health status of patients. A multivariate model based on negative binomial regression was constructed. RESULTS: Of the 3,406 medical records analyzed, 64.2% (n = 2,185) pertained to women, the mean age was 42.45 years, 87.9% did not have diabetes, and 12.1% had received a diagnosis of diabetes. The mean (standard deviation) number of missing teeth was 7.46 (7.89), 7.09 (7.60) in patients without diabetes, and 10.12 (9.32) in patients with diabetes. According to our final multivariate model, the expected mean number of missing teeth was 11.4% higher in patients with diabetes than in those without (P = .006). For every 1-year increase in age, the expected mean number of missing teeth increased by 3.9% (P < .001). Other variables related to tooth loss included occupation, marital status, and type of insurance. CONCLUSIONS: The results of the study indicate that the mean number of missing teeth is higher in people with diabetes and suggest that certain socioeconomic inequalities exist in the area of oral health. PRACTICAL IMPLICATIONS: The population needs to be apprised of the impact of diabetes on oral health.


Assuntos
Diabetes Mellitus , Perda de Dente , Adulto , Estudos Transversais , Feminino , Humanos , México , Saúde Bucal
2.
J Matern Fetal Neonatal Med ; : 1-6, 2019 May 07.
Artigo em Inglês | MEDLINE | ID: mdl-31035800

RESUMO

INTRODUCTION: Preterm delivery is a multifactorial health problem that represents a serious public health problem around the world. In recent years, there has been an increase in scientific evidence suggesting associations between oral health status (mainly periodontal disease and tooth loss) and an increased risk of systemic diseases and various adverse pregnancy outcomes. This study explores the association between indicators of oral health and preterm delivery in a sample of Mexican pregnant women. MATERIALS AND METHODS: A case-control study was carried out with 111 pregnant (36 cases, 75 controls) who received prenatal care and delivered in an obstetric hospital in Pachuca, Mexico. Clinical files were reviewed to obtain the necessary information for the variables studied. The dependent variable was preterm delivery and the independent variables were gingivitis, periodontitis, DMFT index and its components, the number of decayed teeth with pulpal exposure or endodontic lesions, age of the mother, education, alcohol use, smoking status, number of gestations, and sex of the newborn. RESULTS: The average ages were similar between the cases and the controls (24.29 ± 5.42 versus 24.89 ± 5.67, p = .5781). Significant differences were observed with gingivitis (p < .01) and periodontitis (p < .001). In addition, when the severity of gingivitis or periodontitis increased, the percentage of cases of preterm delivery increased (p < .01). The average number of teeth lost was higher among the cases than among the controls (1.33 ± 1.89 versus 0.81 ± 1.82, p < .05). CONCLUSIONS: It was found that gingivitis, periodontitis, and tooth loss were associated with preterm delivery. It is necessary to carry out actions aimed at the preservation of oral health in pregnant patients to avoid adverse results. These findings indicate a likely association, but it needs to be confirmed by large and well-designed studies.

3.
Tumour Biol ; 37(3): 3389-404, 2016 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-26449822

RESUMO

A relationship between Epstein-Barr virus (EBV) infection and cancer of lymphoid and epithelial tissues such as Burkitt's lymphoma, Hodgkin's disease, nasopharyngeal carcinoma (NPC), gastric carcinoma, and oral cancer has been reported. EBV is transmitted orally and infects B cells and epithelial cells. However, it has remained uncertain whether EBV plays a role in carcinogenesis of oral mucosal tissue. In the present study, we detected the EBV genome and latent EBV gene expression in normal mucosal epithelia, epithelial dysplasia, and oral squamous cell carcinoma (OSCC) to clarify whether EBV is involved in carcinogenesis of the oral cavity. We examined 333 formalin-fixed, paraffin-embedded tissue samples (morphologically normal oral mucosa 30 samples, gingivitis 32, tonsillitis 17, oral epithelial dysplasia 83, OSCC 150, and NPC 21). EBV latent infection genes (EBNA-2, LMP-1) were detected not only in OSCC (50.2 %, 10.7 %) but also in severe epithelial dysplasia (66.7 %, 44.4 %), mild to moderate epithelial dysplasia (43.1 %, 18.5 %), gingivitis (78.1 %, 21.9 %), and normal mucosa (83.3 %, 23.3 %). Furthermore, the intensity of EBV latent infection gene expression (EBER, LMP-1) was significantly higher in severe epithelial dysplasia (94.4 %, 72.2 %) than in OSCC (34.7 %, 38.7 %). These results suggest that EBV latent infection genes and their increased expression in severe epithelial dysplasia might play an important role in the dysplasia-carcinoma sequence in the oral cavity.


Assuntos
Carcinoma de Células Escamosas/virologia , Antígenos Nucleares do Vírus Epstein-Barr/genética , Mucosa Bucal/patologia , Mucosa Bucal/virologia , Neoplasias Bucais/virologia , Proteínas da Matriz Viral/genética , Proteínas Virais/genética , Genoma Viral , Humanos
4.
Med Oral Patol Oral Cir Bucal ; 19(6): e538-44, 2014 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-24880448

RESUMO

OBJECTIVE: To evaluate the effectiveness of Toki's criteria in identifying the HPV L1 protein in oral lesions with the use of immunohistochemistry (IHC) and to determine which criteria optimize such identification. STUDY DESIGN: Retrospective study of 277 cases diagnosed as HPV lesions at 22 years. Tests of sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), kappa coefficients, and chi2 values, as well as two logistic regression analyses (p≤0.05), were conducted. RESULTS: Of the lesions studied, 96.4% (267 of 277) were positive for HPV using Toki's criteria and 28.5% (79 of 277) were positive for L1 by IHC. Toki's criteria showed sensitivity=93.67%, specificity=2.53%, PPV=6.99%, and NPV=46.55%. Neither concordance nor statistically significant associations were observed between both tests. The logistic regression of Toki's criteria was useful in the diagnosis of L1, correctly classified 71.8% of the lesions positive for L1, and showed a Hosmer-Lemeshow adjustment of p=0.614 and a Nagelkerke's coefficient of determination of 6.8%. The explanatory variables statistically significant at p≤0.05 were dyskeratosis (p=0.01) and papillomatosis (p=0.04). Forty-nine independent variables (clinical and histopathologic) were involved in the second regression analysis. The model correctly classified 85.2% of the lesions and showed a Hosmer-Lemeshow adjustment of p=0.696 and a Nagelkerke's coefficient of determination of 60.2%. The explanatory variables statistically significant at p≤0.05 were: age younger than 35 years (p=0.001), multiple lesions (p=0.031), hyperorthokeratosis (p=0.019), focal intracellular edema (p=0.002), and the presence of 1 to more than 5 cells with degenerative changes in their nucleus (p=0.048). CONCLUSIONS: Toki's criteria are not adequate to make a diagnosis of lesions by HPV in the mouth, but the logistic regression analysis showed clinical and histopathologic variables which optimize the identification of lesions through the L1 protein. However, a PCR study is advisable when the presence of high-risk HPV is suspected.


Assuntos
Proteínas do Capsídeo/isolamento & purificação , Mucosa Bucal/química , Neoplasias Bucais/diagnóstico , Neoplasias Bucais/virologia , Proteínas Oncogênicas Virais/isolamento & purificação , Infecções por Papillomavirus/patologia , Infecções por Papillomavirus/virologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Feminino , Humanos , Imuno-Histoquímica , Lactente , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Sensibilidade e Especificidade , Adulto Jovem
5.
Angle Orthod ; 81(4): 700-6, 2011 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-21299411

RESUMO

OBJECTIVE: To compare the influence of four systems for dental bleaching on the shear bond strength (SBS) of orthodontic brackets. MATERIALS AND METHODS: One-hundred and fifty freshly extracted bovine teeth were randomly divided into five groups. In group I the teeth were untreated (control). In the remaining groups the teeth were bleached, as follows: group II: 38% hydrogen peroxide; group III: 10% carbamide peroxide; group IV: resin-based coating material (RBCM), Beauty Coat; and group V: RBCM, White Coat. In all groups the enamel was conditioned with a self-etching primer and brackets were bonded with composite resin. Samples were stored (37°C, 24 hours), tested, and statistically analyzed, with significance predetermined at P ≤ .05. The adhesive remnant index (ARI) was also evaluated and analyzed. RESULTS: The SBS of group V (22.49 ± 5.34 MPa) was significantly higher than that of all other groups (I: 17.1 ± 5.11 MPa; II: 14.72 ± 5.42 MPa; III: 12.04 ± 5.29 MPa; and IV: 18.23 ± 5.58 MPa). In contrast, the SBS of group III was significantly lower than that of all groups (except group II). Significant differences in the ARI scores were present between groups. CONCLUSIONS: The use of RBCM for dental bleaching before bonding orthodontic brackets did not reduce the SBS. In contrast, hydrogen and carbamide peroxides negatively affected the SBS. The SBS yielded after bleaching with carbamide peroxide was significantly lower.


Assuntos
Colagem Dentária , Facetas Dentárias , Braquetes Ortodônticos , Clareadores Dentários/química , Clareamento Dental/métodos , Animais , Peróxido de Carbamida , Bovinos , Resinas Compostas/química , Análise do Estresse Dentário , Peróxido de Hidrogênio/química , Peróxidos/química , Distribuição Aleatória , Cimentos de Resina , Resistência ao Cisalhamento , Ureia/análogos & derivados , Ureia/química
6.
Rev. ADM ; 62(5): 191-197, sept.-oct. 2005. ilus
Artigo em Espanhol | LILACS | ID: lil-417870

RESUMO

El propósito de este estudio es discutir el tratamiento de un paciente con retención bilateral de caninos superiores y reabsorción radicular de los dientes adyacentes. Se muestran los problemas asociados con los caninos superiores retenidos y las intervenciones biomecánicas utilizadas en el tratamiento de ortodoncia


Assuntos
Humanos , Feminino , Pré-Escolar , Dente Canino , Ortodontia Corretiva , Dente Impactado , Aparelhos Ortodônticos , Dente Canino , Incisivo , Má Oclusão/terapia , Maxila , Planejamento de Assistência ao Paciente , Reabsorção da Raiz/etiologia , Extração Seriada , Braquetes Ortodônticos
7.
J Oral Sci ; 46(4): 259-66, 2004 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-15901072

RESUMO

A family case of Cleidocranial Dysplasia is presented. A mother and two adolescent girls were examined. In all three cases, a radiological series was performed over the entire body. Generalized dysplasia in bones, prolonged retention of primary teeth, and delayed eruption of permanent, as well as supernumerary teeth was diagnosed. The citogenetic study with GTG band showed normal 46, XX. Bilateral audiometry in the mother demonstrated a mild to moderate hypoacustic condition. Radiological findings are presented and the importance of early diagnosis is discussed.


Assuntos
Displasia Cleidocraniana/complicações , Displasia Cleidocraniana/genética , Anormalidades Maxilomandibulares/etiologia , Anormalidades Dentárias/etiologia , Adolescente , Adulto , Cefalometria , Displasia Cleidocraniana/diagnóstico por imagem , Ossos Faciais/anormalidades , Saúde da Família , Feminino , Perda Auditiva Bilateral/etiologia , Humanos , Anormalidades Maxilomandibulares/diagnóstico por imagem , Masculino , Linhagem , Radiografia , Irmãos , Anormalidades Dentárias/diagnóstico por imagem
8.
Rev. ADM ; 52(3): 129-37, mayo-jun. 1995. tab, ilus
Artigo em Espanhol | LILACS | ID: lil-162978

RESUMO

Con el propósito de detectar las alteraciones de la cavidad bucal y de estructuras relacionadas más frecuentes en población geriátrica, se llevó a cabo un estudio epidemiológico en los 24 municipios que constituyen la región I del estado de México. Un total de 10.561 domicilios fueron visitados, captándose 2.308 personas, de las cuales 699 (30.29 por ciento) fueron varones y 1.609 (69.71 por ciento) mujeres. El examen consistió en la observación y palpación de los tejidos bucales, de la cabeza y del cuello. El diagnóstico se estableció a través de la correlación de los hallazgos clínicos y el interrogatorio. Durante el estudio se detectaron 537 lesiones con una prevalencia de 232 x 1.000 correspondiendo el 66.66 por ciento de los casos al sexo femenino y el 33.34 por ciento al sexo masculino. Las patologías más frecuentes fueron: hiperplasia fibrosa de Fordyce (.08 por ciento), lengua geográfica (6.90 por ciento), nevo pigmentado (5.4 por ciento), hiperplasia epitelial focal (3.16 por ciento), hematoma (3.16 por ciento), hipertrofia papilar (6.1 por ciento) y otras lesiones que en conjunto totalizaron un 29.79 por ciento. Estas prevalencias son diferentes a las reportadas en otros estudios nacionales e internacionales


Assuntos
Humanos , Masculino , Feminino , Idoso , Doenças da Boca/epidemiologia , Odontologia Geriátrica/métodos
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