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1.
Front Psychol ; 13: 859234, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35572241

RESUMO

The Anticipatory and Consummatory Interpersonal Pleasure Scale (ACIPS) is a psychometric instrument that has been used to indirectly measure social anhedonia in many cross-cultural contexts, such as in Western (US), European (French, Spanish), Eastern (Chinese), and Israeli samples. However, little is known about the psychometric properties of the ACIPS in Korean samples. The primary goal of this study was to validate the Korean version of the ACIPS among non-help-seeking individuals. The sample consisted of 307 adult individuals who had no current or prior psychiatric history. Participants were administered the ACIPS, along with the Behavioral Inhibition and Behavioral Activation Scales (BIS/BAS) and Beck Depression Inventory (BDI). We examined the association of the total ACIPS scores with the other measures. The ACIPS showed good internal consistency. We also explored the factor structure of the Korean translation of the ACIPS using principal component analysis with Promax rotation and Kaiser normalization. Factor analysis yielded a three-factor structure that accounted for 58.8% of the variance. The three-factor model included the following subdomains: interactions involving close relationships, casual interactions, and interactions involving family members. Total BAS and BIS scores were significantly associated with total ACIPS scores, while BDI scores were inversely associated with total ACIPS scores. The current research indicates that the Korean version of the ACIPS is a useful and valid scale. Future directions include using the Korean translation of the ACIPS to elucidate the varying degrees of hedonic capacity in psychiatric patients.

3.
Alzheimers Dement ; 2021 Dec 06.
Artigo em Inglês | MEDLINE | ID: mdl-34870885

RESUMO

Black Americans are disproportionately affected by dementia. To expand our understanding of mechanisms of this disparity, we look to Alzheimer's disease (AD) biomarkers. In this review, we summarize current data, comparing the few studies presenting these findings. Further, we contextualize the data using two influential frameworks: the National Institute on Aging-Alzheimer's Association (NIA-AA) Research Framework and NIA's Health Disparities Research Framework. The NIA-AA Research Framework provides a biological definition of AD that can be measured in vivo. However, current cut-points for determining pathological versus non-pathological status were developed using predominantly White cohorts-a serious limitation. The NIA's Health Disparities Research Framework is used to contextualize findings from studies identifying racial differences in biomarker levels, because studying biomakers in isolation cannot explain or reduce inequities. We offer recommendations to expand study beyond initial reports of racial differences. Specifically, life course experiences associated with racialization and commonly used study enrollment practices may better account for observations than exclusively biological explanations.

4.
Dev Psychopathol ; 33(1): 363-371, 2021 02.
Artigo em Inglês | MEDLINE | ID: mdl-32375907

RESUMO

Social anhedonia is well established as a transdiagnostic factor, but little is known about its development. This study examined whether temperament and parenting in early childhood predict social anhedonia in early adolescence. We also explored whether the relationships between early predictors and social anhedonia are moderated by a child's sex. A community sample of children participated in laboratory observations of temperament and parenting practices at age 3 (n = 275). The participants returned at age 12 and completed the Anticipatory and Consummatory Interpersonal Pleasure Scale-Child Version (ACIPS-C). Our results indicated that, at age 3, lower observed sociability predicted higher levels of social anhedonia at age 12. These associations were moderated by child sex, such that males with diminished sociability reported greater social anhedonia. These findings indicate that predictors of early adolescent social anhedonia are evident as early as 3 years of age. However, these effects were evident only for males, suggesting that the pathways to social anhedonia in early adolescence differ as a function of sex.


Assuntos
Anedonia , Temperamento , Adolescente , Criança , Pré-Escolar , Humanos , Masculino , Poder Familiar , Prazer , Inquéritos e Questionários
5.
Affect Sci ; 2(3): 289-300, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-35330700

RESUMO

Disturbances in positive affect and reductions in social reward/interpersonal pleasure are common across a range of clinical disorders and are often related. We examined the relationship between the Anticipatory and Consummatory Interpersonal Pleasure Scale (ACIPS-A), and other measures of positive affect in adolescents in a genetically informative research design. The sample consisted of 177 MZ and 136 same sex DZ twins drawn from a study of adolescent twins (M = 16.4 ± .97 years) who were part of the Wisconsin Twin Project. The self-report questionnaires included the Behavioral Activation Scale (BAS), Psychological Well-Being Scale, revised Early Adolescent Temperament Questionnaire (EATQR) and the adolescent version of the ACIPS (ACIPS-A). Structural equation modeling estimated the relative contribution of genetic and environmental factors to the phenotypic variance in each of the measures. Follow-up bivariate analyses parsed the genetic and environmental contributions to the phenotypic covariances between the ACIPS-A and each of the other measures of positive affect. We found evidence of moderate heritability for the ACIPS-A scale scores. Overall, models specifying additive genetic and unique environmental effects (AE models) were the most parsimonious models for each of the measures. Several of the measures showed moderate positive phenotypic intercorrelations, and all but one of these intercorrelations showed significant partial genetic underpinnings. Moreover, the bivariate biometric analyses indicated that the ACIPS-A also captures unique heritable variation. Thus, the ACIPS-A captures unique heritable contributions to social/interpersonal pleasure, as well as shared genetic variance with other measures of positive affectivity.

7.
Psych J ; 9(2): 160-162, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31958899

RESUMO

The present study validated the Chinese version of the Anticipatory and Consummatory Interpersonal Pleasure Scale (ACIPS) in a group of patients with mental disorders. The results replicated the four-factor structure of the ACIPS in a Chinese setting and showed good discrimination validity.


Assuntos
Anedonia , Relações Interpessoais , Transtornos Mentais , Prazer , Escalas de Graduação Psiquiátrica , Psicometria , Inquéritos e Questionários/normas , Adulto , China , Feminino , Humanos , Masculino , Comportamento Social , Tradução
8.
Schizophr Res ; 212: 6-14, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-31387828

RESUMO

The present study aimed to explore the relationship between autistic and schizotypal traits in the non-clinical population. We first conducted a meta-analysis to quantify the correlation between self-reported autistic traits and the three dimensions of schizotypal traits (positive, negative and disorganization). The strongest correlation was found between autistic traits and negative schizotypal traits (r = 0.536, 95% CI [0.481, 0.586]), followed by the disorganization (r = 0.355, 95% CI [0.304, 0.404]) and positive (r = 0.256, 95% CI [0.208, 0.302]) dimensions. To visualize the partial correlations between dimensional behavioural traits, we constructed a network model based on a large sample of college students (N = 2469). Negative schizotypal traits were strongly correlated with autistic social/communicative deficits, whereas positive schizotypal traits were inversely correlated with autistic-like traits, lending support to the psychosis-autism diametrical model. Disentangling the overlapping and diametrical structure of autism and schizophrenia may help to elucidate the aetiology of these two neurodevelopmental disorders.


Assuntos
Transtorno do Espectro Autista , Modelos Estatísticos , Transtorno da Personalidade Esquizotípica , Adolescente , Adulto , Transtorno do Espectro Autista/classificação , Transtorno do Espectro Autista/fisiopatologia , Feminino , Humanos , Masculino , Transtorno da Personalidade Esquizotípica/classificação , Transtorno da Personalidade Esquizotípica/fisiopatologia , Adulto Jovem
9.
Schizophr Bull ; 44(suppl_2): S460-S467, 2018 10 15.
Artigo em Inglês | MEDLINE | ID: mdl-29788473

RESUMO

The latent structure of schizotypy and psychosis-spectrum symptoms remains poorly understood. Furthermore, molecular genetic substrates are poorly defined, largely due to the substantial resources required to collect rich phenotypic data across diverse populations. Sample sizes of phenotypic studies are often insufficient for advanced structural equation modeling approaches. In the last 50 years, efforts in both psychiatry and psychological science have moved toward (1) a dimensional model of psychopathology (eg, the current Hierarchical Taxonomy of Psychopathology [HiTOP] initiative), (2) an integration of methods and measures across traits and units of analysis (eg, the RDoC initiative), and (3) powerful, impactful study designs maximizing sample size to detect subtle genomic variation relating to complex traits (the Psychiatric Genomics Consortium [PGC]). These movements are important to the future study of the psychosis spectrum, and to resolving heterogeneity with respect to instrument and population. The International Consortium of Schizotypy Research is composed of over 40 laboratories in 12 countries, and to date, members have compiled a body of schizotypy- and psychosis-related phenotype data from more than 30000 individuals. It has become apparent that compiling data into a protected, relational database and crowdsourcing analytic and data science expertise will result in significant enhancement of current research on the structure and biological substrates of the psychosis spectrum. The authors present a data-sharing infrastructure similar to that of the PGC, and a resource-sharing infrastructure similar to that of HiTOP. This report details the rationale and benefits of the phenotypic data collective and presents an open invitation for participation.


Assuntos
Conjuntos de Dados como Assunto , Modelos Teóricos , Transtornos Psicóticos/classificação , Esquizofrenia/classificação , Transtorno da Personalidade Esquizotípica/classificação , Humanos , Disseminação de Informação , Colaboração Intersetorial
10.
Schizophr Bull ; 44(suppl_2): S536-S546, 2018 10 15.
Artigo em Inglês | MEDLINE | ID: mdl-29618094

RESUMO

Meehl conceptualized schizotypy as the phenotypic manifestations of a neural integrative defect resulting from a schizophrenia diathesis. The majority of schizotypy studies recruited subjects from the general population and revealed a multidimensional construct. This 2-phase investigation first examined the clustering of schizotypy in 194 unaffected relatives of schizophrenia patients using the Chapman Psychosis Proneness scales and then directly compared the cognitive profiles of negative schizotypal individuals and positive schizotypal individuals with schizophrenia patients and controls. In the first phase, cluster analysis categorized 194 unaffected relatives of schizophrenia patients into positive schizotypy (n = 33), negative schizotypy (n = 66), mixed schizotypy (n = 27), and low schizotypy (n = 64). Positive schizotypal participants showed more self-report pleasure experiences than negative schizotypal participants, replicating earlier cluster analytic findings. In the second phase, 27 negative schizotypal individuals, 18 positive schizotypal individuals, 19 schizophrenia patients, and 29 controls were recruited. Although the groups were matched in terms of age, gender, and IQ, they differed significantly in cognitive profiles. While schizophrenia patients exhibited the broadest cognitive impairments, negative schizotypal participants exhibited visual memory, working memory, and verbal fluency impairments, and positive schizotypal participants exhibited logical memory, visual memory, working memory, and theory-of-mind impairments. Among people with familial risk of schizophrenia, individuals exhibiting positive rather than negative schizotypal features resembled schizophrenia patients in cognitive profiles. Using the psychometric-familial method to identify schizotypy, our findings support the heterogeneity of schizotypy as well as the potential utility of the positive schizotypy dimension in genetically high-risk individuals to predict the risk of developing schizophrenia.


Assuntos
Disfunção Cognitiva/fisiopatologia , Predisposição Genética para Doença , Esquizofrenia/fisiopatologia , Transtorno da Personalidade Esquizotípica/fisiopatologia , Adolescente , Adulto , Disfunção Cognitiva/etiologia , Família , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Esquizofrenia/complicações , Adulto Jovem
11.
Psychiatry Res ; 264: 398-403, 2018 06.
Artigo em Inglês | MEDLINE | ID: mdl-29679842

RESUMO

Patients with schizophrenia show performance deficits on tasks requiring empathy-related social cognition. The extent to which empathy impairments are observed in psychometric schizotypy is unclear. We compared accuracy and reaction time in three groups of individuals characterized by positive schizotypy (n = 79), negative schizotypy (n = 123), or low schizotypy group (n = 137). On a social cognition task that provided context, namely, the Emotion Perspective Taking Task, the positive schizotypes showed poorer performance than the negative schizotypy and control groups. These results suggest that some schizotypes differ in their ability to make use of context (e.g., social cues from the environment) to affect their social cognitive performance. However, on the Affective Responsiveness Task, in which no context was given, both groups of psychometric schizotypes displayed lower performance than the controls. These findings highlight the importance of assessing multiple groups of schizotypes as well as the value of including several social cognition tasks in order to reveal relative performance deficits.


Assuntos
Cognição/fisiologia , Emoções/fisiologia , Desempenho Psicomotor/fisiologia , Transtorno da Personalidade Esquizotípica/psicologia , Comportamento Social , Adolescente , Transtornos Cognitivos/diagnóstico , Transtornos Cognitivos/fisiopatologia , Transtornos Cognitivos/psicologia , Empatia/fisiologia , Feminino , Humanos , Masculino , Estimulação Luminosa/métodos , Psicometria , Distribuição Aleatória , Tempo de Reação/fisiologia , Esquizofrenia/diagnóstico , Esquizofrenia/fisiopatologia , Transtorno da Personalidade Esquizotípica/diagnóstico , Transtorno da Personalidade Esquizotípica/fisiopatologia , Inquéritos e Questionários , Adulto Jovem
12.
Artigo em Inglês | MEDLINE | ID: mdl-30687788

RESUMO

There are relatively few investigations of the emotion expressivity of children at risk for the later development of schizophrenia and schizophrenia-spectrum disorders. Using data from the New York High-Risk Project, we compared children's emotional expressivity during a semi-structured videotaped interview. Data were coded for 173 child subjects: 61 with schizophrenic parents (HRSz); 54 with affectively ill parents (HRAff); and 58 with psychiatrically "normal" parents (NC). A child's affective responses were rated for the presence of discrete positive, negative, or neutral emotions by coders naive to group membership. Responses were also rated for anxiety, flat affect, inappropriate affect, and emotional withdrawal/disengagement. Compared with the two other two groups, HRSz children displayed significantly more negative affect in response to questions regarding their most negative experiences and, when questioned about their self-concept, they displayed significantly less positive affect. Both HRSz and HRAff children showed more inappropriate affect than NC children. Significantly more HRSz children were rated as demonstrating a lack of emotional engagement. Children making inappropriate displays of positive affect while discussing a negative topic were most likely to manifest a psychiatric disorder as an adult. These findings suggest that inappropriate affect may be a nonspecific indicator of risk for psychopathology. Emotional withdrawal in childhood may be a potential indicator of risk for schizophrenia.

13.
Early Hum Dev ; 116: 28-32, 2018 01.
Artigo em Inglês | MEDLINE | ID: mdl-29112888

RESUMO

BACKGROUND: The second to fourth digit ratio (2D:4D) is used as a marker of prenatal sex hormone exposure. The aim of this study was to evaluate the possible relation between digit ratio and age of pubertal onset. METHODS: Participants were 321 men and 202 women aged between 18 and 28 at the time of assessment who self-reported their onset of puberty (i.e., age at first conscious ejaculation or menarche). Participants' right and left digit lengths were measured from hand scans. RESULTS: All groups of males, i.e., early, average, and late pubertal onset, had lower mean 2D:4D than the comparable female groups, regardless of the relative timing of their pubertal onset. Among the males, there was a significant difference in digit ratios between individuals who experienced early, average, and late onset of puberty. In the males, we observed a positive relationship between 2D:4D and age of pubertal onset for both right and left hands. There were no significant differences in 2D:4D among the three groups of female maturers. We observed no significant association between digit ratios and age at menarche. CONCLUSIONS: These data lend further support for using 2D:4D as a measure of prenatal androgen exposure.


Assuntos
Dedos/anatomia & histologia , Puberdade/fisiologia , Adolescente , Adulto , Fatores Etários , Feminino , Humanos , Masculino , Menarca/fisiologia
14.
Schizophr Res ; 193: 384-390, 2018 03.
Artigo em Inglês | MEDLINE | ID: mdl-28751128

RESUMO

Schizotypy is a set of personality traits that convey liability to develop schizophrenia. Studying schizotypy in healthy individuals may facilitate the understanding of the psychopathological processes underlying schizophrenia. The present study aimed to examine the developmental trajectories of schizotypy over time using a longitudinal study design. The Chapman Scales for Psychosis Proneness were administered to 1541 college students at baseline, and subsequently at six-monthly intervals up to 18months. Latent class growth analysis was conducted to track the different trajectories. In addition, self-reported scales were used to measure idea of reference, emotional experiences and expression, stress and coping, as well as social functioning. We identified four latent classes with distinct trajectories: "nonschizotypy" group (LC1), "stable high schizotypy" group (LC3), "high reactive schizotypy" group (LC2) and "low reactive schizotypy" group (LC4). These findings suggest that there may be distinct developmental trajectories for schizotypy. Two groups may be of particular interest: the "stable high schizotypy" group that displayed the worst clinical and functioning outcomes on almost all measures and the "high reactive schizotypy" group characterized by a relatively rapid decline in functioning.


Assuntos
Transtornos do Humor/etiologia , Transtorno da Personalidade Esquizotípica/complicações , Transtorno da Personalidade Esquizotípica/psicologia , Comportamento Social , Adaptação Psicológica , Adolescente , Análise de Variância , Feminino , Humanos , Estudos Longitudinais , Masculino , Escalas de Graduação Psiquiátrica , Psicometria , Fatores de Tempo , Adulto Jovem
15.
Psychiatry Res ; 257: 418-423, 2017 11.
Artigo em Inglês | MEDLINE | ID: mdl-28837930

RESUMO

Nearly all self-report measures of anhedonia have been developed for use in adults. Recently we developed an age and developmentally appropriate measure of social/interpersonal pleasure for adolescents (ACIPS-A), whereby lower scores are indicative of social anhedonia. However the scale had not been administered to Eastern samples. The adolescent version of the Anticipatory and Consummatory Interpersonal Pleasure Scale (ACIPS-A) was administered to a general, community-derived Chinese adolescent sample of 442 students, including 186 males (44%), who ranged in age from 12 to 18 years old. The 20-item Chinese Temporal Experience of Pleasure (TEPS) was also administered to the sample. Exploratory factor analysis revealed that three factors (Casual bonding, Close relationships, and Shared interests) accounted for nearly 69% of the variance. The total ACIPS-A showed excellent internal consistency, with ordinal alpha = 0.94. Scores on the adolescent version of the ACIPS were positively and significantly associated with total scores on the four Chinese TEPS subscales. The ACIPS-A is a sufficiently robust measure to be useful and valid in Chinese samples as well as in Western (i.e. European and U.S.) samples.


Assuntos
Anedonia/fisiologia , Apego ao Objeto , Prazer/fisiologia , Comportamento Social , Adolescente , Criança , Feminino , Humanos , Masculino , Psicometria , Autorrelato , Estudantes/psicologia , Inquéritos e Questionários
16.
Front Psychol ; 8: 1296, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28804473

RESUMO

The Anticipatory and Consummatory Interpersonal Pleasure Scale (ACIPS), a measure specifically designed to assess hedonic capacity for social and interpersonal pleasure, was used to evaluate the presence of social anhedonia in patients as well as the general population. The first goal of this study was to validate the structure of the French version of the ACIPS. The second objective was to verify whether a one, two or three factor solution is most appropriate for the ACIPS scale. The French version of the ACIPS was tested on 263 French-speaking pre-graduate students or professional volunteers. For the confirmatory factor analysis, data were treated as categorical ordinal and all the models were estimated using a robust weighted least squares estimator with adjustments for the mean and variance. Three models were estimated. A one-factor model representing a general undifferentiated "pleasure" latent construct was first tested on the 17 ACIPS items. A two-factor model distinguishing anticipatory-pleasure and consummatory-pleasure was tested next. Finally, a three-factor model including subdomains of intimate social interactions, group social interactions, and social bonding was tested. The one and two-factor models showed a somewhat poor fit to the data. However, the goodness of fit of the three factor model was adequate. These results suggest that individuals who enjoyed interaction in one of these three subdomains were more likely to enjoy doing so in the two other domains. However, on the basis of the comparison between the one and three factor models, these three types of interactions may not be considered as indistinguishable. Rather, they represent distinct and theoretically meaningful dimensions. These results show the French version of the ACIPS is a useful and valid scale to measure the capacity of savoring different kinds of social relationships.

17.
Front Psychol ; 8: 147, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28223956

RESUMO

The goal was to examine the nature of social anhedonia using two validated measures and study their relationship to scores on the NEO-Five Factor Inventory (NEO-FFI). Nearly 1,900 college-aged participants completed the Chapman Revised Social Anhedonia Scale (RSAS), Anticipatory and Consummatory Interpersonal Pleasure Scale (ACIPS), and the NEO-FFI. Although both the RSAS and ACIPS were associated with the NEO-FFI domains of Extraversion, Agreeableness, and Neuroticism, linear regression analyses revealed that the RSAS and ACIPS were differentially predicted by NEO-FFI item clusters. The RSAS scores were predicted by Sociability, Nonantagonistic Orientation, Positive Affect, and Activity item clusters. The ACIPS scores were predicted by Sociability, Prosocial Orientation, Activity, and Positive Affect item clusters in addition to gender. In summary, it appears that social anhedonia is multidimensional, associated with various personality domains encompassing social approach and withdrawal.

18.
Psych J ; 5(4): 238-244, 2016 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-27667317

RESUMO

Social anhedonia, the reduced capacity for social and interpersonal pleasure, often accompanies several forms of psychopathology. The goal of the present study was to validate the Chinese translation of the Anticipatory and Consummatory Interpersonal Pleasure Scale (ACIPS), a promising new tool for the assessment of individual differences in social pleasure. The Chinese versions of the ACIPS, the Temporal Experience of Pleasure Scale (TEPS), and the Schizotypal Personality Questionnaire (SPQ) were administered to 389 nonclinical adults. Factor analysis revealed that a four-factor structure accounted for nearly 53% of the variance, and the factors were consistent with those identified from factor analyses of the ACIPS in Western (U.S.) samples. The ACIPS measure showed high internal consistency as well. Correlational analysis revealed evidence of convergent validity. Individuals who scored high on the ACIPS were more likely to score high on measures of anticipatory and consummatory pleasure. Moreover, ACIPS total scores were inversely associated with scores on the No Close Friends subscale and the Constricted Affect subscale of the Schizotypal Personality Questionnaire (SPQ). Taken together, the findings suggest that the Chinese translation of the ACIPS is a reliable, valid measure that can be used to assess individual differences in the capacity to experience social and interpersonal pleasure in Chinese individuals.


Assuntos
Anedonia , Prazer , Psicometria , Adulto , Análise Fatorial , Feminino , Humanos , Masculino , Inquéritos e Questionários
19.
Psychiatry Res ; 243: 246-54, 2016 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-27423122

RESUMO

This study is an attempt to evaluate extant psychometric indicators using latent profile analysis for classifying community-derived individuals based on a set of clinical, behavioural, and personality traits considered risk markers for psychosis spectrum disorders. The present investigation included four hundred and forty-nine high-school students between the ages of 12 and 19. We used the following to assess risk: the Prodromal Questionnaire-Brief (PQ-B), Oviedo Schizotypy Assessment Questionnaire (ESQUIZO-Q), Anticipatory and Consummatory Interpersonal Pleasure Scale-Adolescent version (ACIPS-A), and General Health Questionnaire 12 (GHQ-12). Using Latent profile analysis six latent classes (LC) were identified: participants in class 1 (LC1) displayed little or no symptoms and accounted for 38.53% of the sample; class 2 (LC2), who accounted for 28.06%, also produced low mean scores across most measures though they expressed somewhat higher levels of subjective distress; LC3, a positive schizotypy group (10.24%); LC4 (13.36%), a psychosis high-risk group; LC5, a high positive and negative schizotypy group (4.45%); and LC6, a very high distress, severe clinical high-risk group, comprised 5.34% of the sample. The current research indicates that different latent classes of early individuals at risk can be empirically defined in adolescent community samples using psychometric indicators for psychosis spectrum disorders. These findings may have implications for early detection and prevention strategies in psychosis spectrum disorders.


Assuntos
Personalidade , Transtornos Psicóticos/diagnóstico , Adolescente , Feminino , Humanos , Masculino , Psicometria , Transtornos Psicóticos/psicologia , Medição de Risco , Fatores de Risco , Fatores Sexuais , Inquéritos e Questionários
20.
PLoS One ; 11(6): e0157084, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27299996

RESUMO

There is a need for a better understanding of transdiagnostic psychiatric symptoms that relate to neurophysiological abnormalities following rewarding and aversive feedback in order to inform development of novel targeted treatments. To address this need, we examined a transdiagnostic sample of 44 adults (mean age: 35.52; 57% female), which consisted of individuals with broadly-defined schizophrenia-spectrum disorders (n = 16), bipolar disorders (n = 10), other mood and anxiety disorders (n = 5), and no history of a psychiatric disorder (n = 13). Participants completed a Pavlovian monetary reward prediction task during 32-channel electroencephalogram recording. We assessed the event-related potentials (ERPs) of feedback-related negativity (FRN), feedback-related positivity (FRP), and the late positive potential (LPP), following better and worse than expected outcomes. Examination of symptom relationships using stepwise regressions across the entire sample revealed that an increase in the clinician-rated Negative Symptoms factor score from the Positive and Negative Syndrome Scale, was related to a decreased LPP amplitude during better than expected (i.e., rewarding) outcomes. We also found that increased self-reported scores on the Schizotypal Personality Questionnaire (Brief-Revised) Disorganized factor related to an increased FRN amplitude during worse than expected (i.e., aversive) outcomes. Across the entire sample, the FRP component amplitudes did not show significant relationships to any of the symptoms examined. Analyses of the three diagnostic groups of schizophrenia-spectrum disorders, bipolar disorders, and nonpsychiatric controls did not reveal any statistically significant differences across the ERP amplitudes and conditions. These findings suggest relationships between specific neurophysiological abnormalities following rewarding and aversive outcomes and particular transdiagnostic psychiatric symptoms.


Assuntos
Transtornos de Ansiedade/diagnóstico , Transtorno Bipolar/diagnóstico , Potenciais Evocados , Esquizofrenia/diagnóstico , Adulto , Afeto , Transtornos de Ansiedade/fisiopatologia , Transtorno Bipolar/fisiopatologia , Eletroencefalografia , Retroalimentação , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Recompensa , Esquizofrenia/fisiopatologia , Adulto Jovem
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