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1.
Rev Neurol ; 78(7): 185-197, 2024 04 01.
Artigo em Espanhol | MEDLINE | ID: mdl-38502167

RESUMO

INTRODUCTION: The primary objective of the core data set is to reduce heterogeneity and promote harmonization among data sources in EM, thereby reducing the time needed to execute real life data collection efforts. Recently, a group led by the Multiple Sclerosis Data Alliance has developed a core data set for collecting real-world data on multiple sclerosis (MS) globally. Our objective was to adapt this global data set to the needs of Latin America, so that it can be implemented by the registries already developed and in the process of development in the region. MATERIAL AND METHODS: A working group was formed regionally, the core data set created globally was adapted (translation process into Spanish, incorporation of regional variables and consensus on variables to be used). Consensus was obtained through the remote Delphi methodology of a round of questionnaires and remote discussion of the core data set variables. RESULTS: A total of 25 professionals from Latin America carried out the adaptation process between November 2022 and July 2023. Agreement was established on a core data set of nine categories and 45 variables, version 2023 to suggest its implementation in developed or developing registries, and MS cohorts in the region. CONCLUSION: The core data set seeks to harmonize the variables collected by registries and cohorts in MS in Latin America in order to facilitate said collection and allow collaboration between sources. Its implementation will facilitate real life data collection and collaboration in the region.


TITLE: Core data set para la generación de datos de la vida real en esclerosis múltiple: adaptación de una iniciativa global para América Latina.Introducción. Los objetivos primarios del core data set son reducir la heterogeneidad y promover la armonización entre las fuentes de datos en la esclerosis múltiple (EM), reduciendo así el tiempo necesario para ejecutar esfuerzos en la recolección de datos de vida real. Recientemente, un grupo liderado por la Multiple Sclerosis Data Alliance ha desarrollado un core data set para la recolección de datos del mundo real en EM a nivel global. Nuestro objetivo ha sido adaptar y consensuar este conjunto de datos globales a las necesidades de América Latina para que pueda ser implementado por los registros ya desarrollados y en proceso de desarrollo en la región. Material y métodos. Se conformó un grupo de trabajo regionalmente y se adaptó el core data set creado globalmente (proceso de traducción al español, incorporación de variables regionales y consenso sobre variables que se iban a utilizar). El consenso se obtuvo a través de la metodología Delphi remoto de ronda de cuestionarios y discusión a distancia de las variables del core data set. Resultados. Veinticinco profesionales de América Latina llevaron adelante el proceso de adaptación entre noviembre de 2022 y julio de 2023. Se estableció un acuerdo sobre un core data set de nueve categorías y 45 variables, versión 2023, con la sugerencia de implementarlo en registros desarrollados o en vías de desarrollo y cohortes de EM en la región. Conclusión. El core data set busca armonizar las variables recolectadas por los registros y las cohortes de EM en América Latina con el fin de facilitar dicha recolección y permitir una colaboración entre fuentes. Su implementación facilitará la recolección de datos de vida real y la colaboración en la región.


Assuntos
Esclerose Múltipla , Humanos , América Latina/epidemiologia , Esclerose Múltipla/epidemiologia , Comitês Consultivos , Consenso , Sistema de Registros
2.
Environ Res ; 222: 115358, 2023 04 01.
Artigo em Inglês | MEDLINE | ID: mdl-36702188

RESUMO

The subject of water contamination and how it gets defiled to the society and humans is confabulating from the past decades. Phenolic compounds widely exist in the water sources and it is emergent to determine the toxicity in natural and drinking water, because it is hazardous to the humans. Among these compounds, catechol has sought a strong concern because of its rapid occurrence in nature and its potential toxicity to humans. The present work aims to develop an effective electrochemical sensing of catechol using mesoporous structure of Fe3O4-TiO2 decorated on glassy carbon (GC) electrode. The creation of pure TiO2 using the sol-gel technique was the first step in the synthesis protocol for binary nanocomposite, which was then followed by the loading of Fe3O4 nanoparticles on the surface of TiO2 using the thermal decomposition method. The resultant Fe3O4-TiO2 based nanocomposite exhibited mesoporous structure and the cavities were occupied with highly active magnetite nanoparticles (Fe3O4) with high specific surface area (90.63 m2/g). When compared to pure TiO2, catechol showed a more prominent electrochemical response for Fe3O4-TiO2, with a significant increase in anodic peak current at a lower oxidation potential (0.387 V) with a detection limit of 45 µM. Therefore, the prepared magnetite binary nanocomposite can serve as an efficient electroactive material for sensing of catechol, which could also act as a promising electrocatalyst for various electrocatalytic applications.


Assuntos
Carbono , Nanopartículas de Magnetita , Humanos , Carbono/química , Nanopartículas de Magnetita/química , Catecóis , Água
3.
Environ Res ; 216(Pt 1): 114428, 2023 01 01.
Artigo em Inglês | MEDLINE | ID: mdl-36179883

RESUMO

Creating mesoporous architecture on the surface of metal oxides without using pore creating agent is significant interest in electrochemical sensors because these materials act as an efficient electron transfer process between the electrode interface and the analytes. Recent advances in mesoporous titanium dioxide (TiO2)-based materials have acquired extraordinary opportunities because of their interconnected porous structure could act as a host for doping with various transition metals or heteroatoms to form a new type of heterojunction. Herein, a simple method is developed to synthesize mesoporous copper oxide (CuO) decorated on TiO2 nanostructures in which homogenous shaped CuO nanocrystals act as dopants decorated on the mesoporous structure of TiO2, resulting in p-n heterojunction nanocomposite. The TiO2 particles exhibit a mesoporous structure with a pore volume of about 0.117 cm3/g is capable to load CuO nanocrystals on the surface. As a result, large pore volume 0.304 cm³/g is obtained for CuO-TiO2 heterojunction nanocomposite with the loading of uniform-shaped CuO nanocrystals on the mesoporous TiO2. The resulting CuO-TiO2 nanocomposite on modified glassy carbon (GC) electrode exhibits good electrochemical performance for oxidation of catechol with the observation of strong enhancement in the anodic peak potential at +0.36 V. The decrease in the overpotential for the oxidation of catechol when compared to TiO2/GC is attributed to the presence of CuO nanocrystals providing a large surface area, resulting in wide linear range 10 nM to 0.57 µM. Moreover, the resultant modified electrode exhibited good sensitivity, selectivity and reproducibility and the sensor could able to determine the presence of catechol in real samples such as lake and river water. Therefore, the obtained CuO-TiO2 nanocomposite on the modified GC delivered good electrochemical sensing performance and which could be able to perform a promising strategy for designing various metal oxide doped nanocomposites for various photochemical and electrocatalytic applications.


Assuntos
Técnicas Eletroquímicas , Nanocompostos , Técnicas Eletroquímicas/métodos , Reprodutibilidade dos Testes , Cobre/química , Nanocompostos/química , Óxidos/química , Carbono/química , Catecóis , Água
4.
Environ Res ; 215(Pt 3): 114427, 2022 12.
Artigo em Inglês | MEDLINE | ID: mdl-36179884

RESUMO

The capacity to generate a constant signal response from an enzyme on an electrode surface has been a fascinating topic of research from the past three decades. To nourish the enzymatic activity during electrochemical reactions, the immobilization of dual enzymes on the electrode surface could prevent the enzymatic loss without denaturation and thus long-term stability can be achieved. For effective immobilization of dual enzymes, mesoporous materials are the ideal choice because of its numerous advantages such as 1. The presence of porous structure facilitates high loading of enzymes 2. The formation of protective environment can withstand the enzymatic activity even at acidic or basic pH values and even at elevated temperatures. Herein, we develop bienzymatic immobilization of horseradish peroxidase (HRP) and cholesterol oxidase (ChOx) on mesoporous V2O5-TiO2 based binary nanocomposite for effective sensing of hydrogen peroxide (H2O2) in presence of redox mediator hydroquinone (HQ). The utilization of redox mediator in second-generation biosensing of H2O2 can eliminate the interference species and reduces the operating potential with higher current density for electrochemical reduction reaction. Using this mediator transfer process approach at HRP/ChOx/V2O5-TiO2 modified GC, the H2O2 can be determined at operating potential (-0.2 V) with good linear range (0.05-3.5 mM) higher sensitivity (1040 µAµM-1 cm-2) and lower detection limit of about 20 µM can be attained, which is due to higher mediation of electrons were transferred to the enzyme cofactors. These interesting characteristics could be due to mesoporous structure of V2O5-TiO2 can induce large immobilization and facilitate higher interaction with enzymes for wide range of biosensing applications.


Assuntos
Técnicas Biossensoriais , Peróxido de Hidrogênio , Colesterol Oxidase , Coenzimas , Enzimas Imobilizadas/química , Peroxidase do Rábano Silvestre/química , Peróxido de Hidrogênio/química , Hidroquinonas , Titânio
5.
Food Chem Toxicol ; 165: 113182, 2022 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-35643232

RESUMO

Enhancing the current signal response for semiconductors is the key factor for designing and fabrication of efficient electrode in electrochemical sensors. By the aid of doping with binary metal oxides, the conductivity of the resultant titanium oxide (TiO2) based nanocomposite will deliver fast electron transfer rate at the heterojunction interface. Herein, by taking advantage of mesoporous structure in TiO2, cubic shaped multivalent cerium oxide (CeO2) was incorporated into the porous cavity by simple ground assisted solvothermal process, which resulted in enormous enhancement in the current response towards detection of 2-aminophenol. The advantage of CeO2 on TiO2 not only involves the loading of binary metal oxide on its mesoporous sites, but also facilitates the formation of CeO2 nanocrystals which induce larger surface area and high electroactive sites with rapid diffusion of target species through pores. As a result, CeO2-TiO2 on modified GC electrode exhibits drastic enhancement in the current response for oxidation of 2-aminophenol with large decrease in the onset potential than TiO2/GC electrode. Furthermore, the CeO2-TiO2 modified electrode shows significant behavior for sensing of 2-aminophenol with wide linear range of 0.01-500 µM. The sensitivity and detection limit were calculated to be 0.603 µA µM cm-2 and 3.5 nM respectively. This work establishes the facile strategy for decoration of binary metal oxide-based nanocomposites as effective electrode and also possible to create new opportunities in the designing and fabrication of variety of efficient electrode in various electrochemical applications.


Assuntos
Nanopartículas Metálicas , Titânio , Aminofenóis , Técnicas Eletroquímicas/métodos , Nanopartículas Metálicas/química , Óxidos/química , Titânio/química
6.
Environ Pollut ; 287: 117304, 2021 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-34015669

RESUMO

The treatment of industrial waste and harmful bacteria is an important topic due to the release of toxins from the industrial pollutants that damage the water resources. These harmful sources frighten the life of every organism which was later developed as the carcinogenic and mutagenic agents. Therefore, the current study focuses on the breakdown or degradation of 4-chlorophenol and the antibacterial activity against Escherichia coli (E. coli). As a well-known catalyst, pure titanium-di-oxide (TiO2) had not shown the photocatalytic activity in the visible light region. Hence, band position of TiO2 need to be shifted to bring out the absorption in the visible light region. For this purpose, the n-type TiO2 nanocrystalline material's band gap got varied by adding different ratios of p-type CuO. The result had appeared in the formation of p (CuO) - n (TiO2) junction synthesized from sol-gel followed by chemical precipitation methods. The optical band gap value was determined by Kubelka-Munk (K-M) plot through UV-Vis diffusive reflectance spectroscopy (DRS). Further, the comprehensive mechanism and the results of photocatalytic and antibacterial activities were discussed in detail. These investigations are made for tuning the TiO2 catalyst towards improving or eliminating the existing various environmental damages.


Assuntos
Escherichia coli , Titânio , Antibacterianos , Catálise , Clorofenóis , Cobre , Luz , Fotólise
7.
Environ Res ; 195: 110852, 2021 04.
Artigo em Inglês | MEDLINE | ID: mdl-33556356

RESUMO

In recent times, cost effective synthesis of semiconductor materials has been a subject of concern for the day to today applications. In this work, novelty has been made on the facile synthesis of metal oxides (TiO2 and CeO2) and nanocomposites (TiO2-CeO2) through sol-gel and precipitation methods of imparting lemon extract. The synthesized materials behave as the functional catalysts which has been further carried out for the photocatalytic degradation against 2,4-Dichlorophenol (2,4-DCP). The materials are then valued for the structural and optical properties. The lemon extract used in synthesis has played a premier role in upgrading the charge carrier separation, bandgap, and size reduction of the composite system. Further, the CeO2 supported TiO2 sample acts as the better visible light catalyst, due to the prevention of aggregation and existence of line dislocation that supported to access the additional electron trap sites.


Assuntos
Clorofenóis , Nanocompostos , Titânio
9.
Sci Rep ; 6: 31641, 2016 08 16.
Artigo em Inglês | MEDLINE | ID: mdl-27528264

RESUMO

In this study, pure ZnO, CeO2 and ZnO/CeO2 nanocomposites were synthesized using a thermal decomposition method and subsequently characterized using different standard techniques. High-resolution X-ray photoelectron spectroscopy measurements confirmed the oxidation states and presence of Zn(2+), Ce(4+), Ce(3+) and different bonded oxygen species in the nanocomposites. The prepared pure ZnO and CeO2 as well as the ZnO/CeO2 nanocomposites with various proportions of ZnO and CeO2 were tested for photocatalytic degradation of methyl orange, methylene blue and phenol under visible-light irradiation. The optimized and highly efficient ZnO/CeO2 (90:10) nanocomposite exhibited enhanced photocatalytic degradation performance for the degradation of methyl orange, methylene blue, and phenol as well as industrial textile effluent compared to ZnO, CeO2 and the other investigated nanocomposites. Moreover, the recycling results demonstrate that the ZnO/CeO2 (90:10) nanocomposite exhibited good stability and long-term durability. Furthermore, the prepared ZnO/CeO2 nanocomposites were used for the electrochemical detection of uric acid and ascorbic acid. The ZnO/CeO2 (90:10) nanocomposite also demonstrated the best detection, sensitivity and performance among the investigated materials in this application. These findings suggest that the synthesized ZnO/CeO2 (90:10) nanocomposite could be effectively used in various applications.

10.
Univ. psychol ; 13(2): 585-599, abr.-jun. 2014. ilus, tab
Artigo em Espanhol | LILACS | ID: lil-735215

RESUMO

Los grupos de trabajo son centrales en las organizaciones actuales, y uno de los procesos más relevantes es el aprendizaje de equipo, su desarrollo y sus antecedentes. El presente estudio tiene dos objetivos principales: 1) analizar el efecto del clima del grupo sobre el desarrollo del aprendizaje de equipo y 2) estudiar el rol modulador de diferentes estresores de equipo (sobrecarga y presión temporal) en dicha relación. Los resultados muestran que el clima del equipo influye de manera concurrente y diferida sobre el aprendizaje. La sobrecarga de trabajo modula la relación entre el apoyo a la innovación y el aprendizaje de equipo al inicio del trabajo en grupo. Sin embargo, la presión temporal no parece tener efectos en dicha relación.


Teams are central work units in organizations. One of the processes that are receiving attention is team learning. The focus is on those processes that can predict team learning and its evolution over time. This study has two objectives. First, analyze team climate effect on team learning development. Second, test the moderator role of team stressors (work overload and time pressure) in the relationship between tem climate and team learning. Results obtained shows that team climate have concurrent and differed effects on team learning. On the other hand, work overload moderates the relationship between support for innovation and team learning at the beginning of teamwork, but time pressure does not have effects in the relationship between team climate and team learning.


Assuntos
Aprendizagem
11.
Mult Scler ; 19(2): 145-52, 2013 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-22492129

RESUMO

A very high prevalence of multiple sclerosis (MS) has been reported in some Western European and North American countries. The few surveys of MS epidemiology in South America reveal lower prevalence rates, implying that susceptibility varies between distinct ethnic groups, thus forming an important determinant of the geographic distribution of the disease. The objective of this study is to review MS prevalence estimates in different Latin American and Caribbean countries. We reviewed surveys of regional MS prevalence from 1991 to 2011. Sources included an online database, authors' reports and proceedings or specific lectures from regional conferences. We obtained a total of 30 prevalence surveys from 15 countries, showing low/medium MS prevalence rates. Both the number and the quality of prevalence surveys have greatly improved in this region over recent decades. This is the first collaborative study to map the regional frequency of MS. Establishment of standardized methods and joint epidemiological studies will advance future MS research in Latin America and the Caribbean.


Assuntos
Esclerose Múltipla/epidemiologia , Região do Caribe/epidemiologia , Coleta de Dados , Notificação de Doenças , Etnicidade , Geografia , Humanos , América Latina/epidemiologia , Prevalência , América do Sul/epidemiologia , Raios Ultravioleta
12.
Mult Scler ; 19(7): 844-54, 2013 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-23045380

RESUMO

The incidence and prevalence of multiple sclerosis (MS) varies geographically as shown through extensive epidemiological studies performed mainly in developed countries. Nonetheless, scant data is available in Latin America and the Caribbean (LAC). The objective of this review is to assess epidemiological data of MS in LAC. We conducted a systematic review of published articles and gray literature from January 1995 to May 2011. Twenty-two studies met the inclusion criteria after full-text review. Incidence data were found in only three studies and ranged from 0.3 to 1.9 annual cases per 100,000 person-years. Prevalence was reported in 10 studies and ranged from 0.83 to 21.5 cases per 100,000 inhabitants. The most prevalent subtype of MS was the relapsing-remitting form (48% to 91% of the series). No data about mortality were found. This study showed low frequency for MS in LAC compared with North American and European countries. The role of environmental and genetic factors should be well studied, providing new insights about its etiology.


Assuntos
Esclerose Múltipla/epidemiologia , Região do Caribe/epidemiologia , Humanos , Incidência , América Latina/epidemiologia , Prevalência
13.
Nanoscale Res Lett ; 7(1): 604, 2012 Oct 30.
Artigo em Inglês | MEDLINE | ID: mdl-23110990

RESUMO

Structural, compositional, morphological, and optical properties of silicon nanocrystal (Si-nc) embedded in a matrix of non-stoichiometric silicon oxide (SiOx) films were studied. SiOx films were prepared by hot filament chemical vapor deposition technique in the 900 to 1,400°C range. Different microscopic and spectroscopic characterization techniques were used. The film composition changes with the growth temperature as Fourier transform infrared spectroscopy, energy dispersive X-ray spectroscopy, and X-ray photoelectron spectroscopy reveal. High-resolution transmission electron microscopy supports the existence of Si-ncs with a diameter from 1 to 6.5 nm in the matrix of SiOx films. The films emit in a wide photoluminescent spectrum, and the maximum peak emission shows a blueshift as the growth temperature decreases. On the other hand, transmittance spectra showed a wavelength shift of the absorption border, indicating an increase in the energy optical bandgap, when the growth temperature decreases. A relationship between composition, Si-nc size, energy bandgap, PL, and surface morphology was obtained. According to these results, we have analyzed the dependence of PL on the composition, structure, and morphology of the Si-ncs embedded in a matrix of non-stoichiometric SiOx films.

14.
Neuroepidemiology ; 32(4): 287-93, 2009.
Artigo em Inglês | MEDLINE | ID: mdl-19246933

RESUMO

BACKGROUND: The first cases of multiple sclerosis (MS) in Panama were notified in the 1980s and it was considered a low-risk region for this disease. Between 2000 and 2005, a prevalence study was conducted to characterize MS in Panama. METHODS: An instrument was developed to gather information from clinical files and interviews with previous informed consent. The diagnosis was confirmed by neurologists applying the Poser and McDonald criteria as per the inclusion period. RESULTS: 178 patients from the public and private health sectors were captured between 1970 and 2005. The prevalence rate was 5.24/100,000 inhabitants, and the incidence was between 0.28 and 0.61/100,000 inhabitants. The disease was predominant among women, the mean age +/- SD being 34.76 +/- 10.909 years (1st crisis), and the average number of crises was 2.88. The most common clinical findings were motor, optic neuritis, sensitive and cerebellous. 52.4% presented monosymptomatic manifestations, 71.6% were clinically defined according to Poser's criteria and 55.6% had MS according to McDonald's criteria. 77.8% had their debut with the relapsing-remitting type and presented an Expanded Disability Status Scale score of 2.7 after the first crisis. CONCLUSION: MS is in Panama a neurological pathology with a low prevalence and the results of this investigation improved early treatment and diagnosis of this disease.


Assuntos
Esclerose Múltipla/epidemiologia , Adolescente , Adulto , Idade de Início , Idoso , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Transtornos dos Movimentos/epidemiologia , Transtornos dos Movimentos/etiologia , Esclerose Múltipla/complicações , Esclerose Múltipla Recidivante-Remitente/complicações , Esclerose Múltipla Recidivante-Remitente/epidemiologia , Testes Neuropsicológicos , Neurite Óptica/epidemiologia , Neurite Óptica/etiologia , Panamá/epidemiologia , Prevalência , Índice de Gravidade de Doença , Fatores Sexuais , Adulto Jovem
15.
Virology ; 277(1): 14-9, 2000 Nov 10.
Artigo em Inglês | MEDLINE | ID: mdl-11062031

RESUMO

Hantavirus pulmonary syndrome (HPS), a severe respiratory disease with high mortality caused by rodent-borne hantaviruses, has previously been identified in the United States and Canada as well as central and southern South America. In late 1999 and early 2000, an outbreak of acute illness compatible with HPS was reported in Los Santos, Panama, with the death of 3 of the 12 (25%) suspected cases. Hantavirus-specific antibodies were detected in patient sera, and virus RNA was detected by reverse transcriptase-polymerase chain reaction. Sequence analysis of virus genome N-, G1-, and G2-encoding fragments showed this to be a novel hantavirus, Choclo virus. Serologic and virus genetic analyses of rodents trapped in the area showed Oligoryzomys fulvescens to be the likely reservoir for the HPS-associated Choclo virus. In addition, Zygodontomys brevicauda rodents were shown to harbor another genetically unique hantavirus, Calabazo virus.


Assuntos
Reservatórios de Doenças , Síndrome Pulmonar por Hantavirus/virologia , Orthohantavírus/classificação , Filogenia , Animais , Canadá , Primers do DNA , Genoma Viral , Orthohantavírus/genética , Orthohantavírus/isolamento & purificação , Síndrome Pulmonar por Hantavirus/classificação , Humanos , Nucleocapsídeo/genética , Panamá , Ratos , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Sorotipagem , América do Sul , Estados Unidos
16.
Acta Neurol Scand ; 101(6): 405-12, 2000 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-10877159

RESUMO

Cerebellar symptoms at onset are unusual in HTLV-I/II-associated tropical spastic paraparesis (TSP). A prospective study of neurological disorders in Panama (1985-1990) revealed 13 patients with TSP and 3 with HTLV-I/II-associated spinocerebellar syndrome (HSCS) presenting at onset loss of balance, wide-based stance and gait, truncal instability, and mild leg ataxia (vermian cerebellar syndrome), with absent upper limb dysmetria but with postural tremor, downbeat nystagmus, and dysarthria. In 4-5 years, spinal cord manifestations of TSP developed, including spastic paraparesis, pyramidal signs, bladder and sphincter disturbances. Two patients were infected with HTLV-I and another one, a Guaymi Amerindian woman, with HTLV-II. Magnetic resonance imaging (MRI) demonstrated cerebellar atrophy involving predominantly the superior vermis. Mild axonal peripheral neuropathy in the lower limbs, dorsal column involvement and inflammatory myopathy were found by neurophysiology studies. There are 14 similar cases reported in Japan and Canada, but to our knowledge these are the first documented cases of HSCS in the tropics. A cerebellar syndrome constitutes another form of presentation of HTLV-I/II infection of the nervous system.


Assuntos
Cerebelo/patologia , Cerebelo/virologia , Infecções por Deltaretrovirus/complicações , Infecções por Deltaretrovirus/patologia , Vírus Linfotrópico T Tipo 1 Humano/fisiologia , Vírus Linfotrópico T Tipo 2 Humano/fisiologia , Degenerações Espinocerebelares/patologia , Degenerações Espinocerebelares/virologia , Cerebelo/fisiopatologia , Infecções por Deltaretrovirus/virologia , Feminino , Humanos , Imageamento por Ressonância Magnética , Pessoa de Meia-Idade , Panamá , Degenerações Espinocerebelares/fisiopatologia
17.
Rev Gastroenterol Mex ; 65(3): 124-8, 2000.
Artigo em Espanhol | MEDLINE | ID: mdl-11464605

RESUMO

OBJECTIVE: A clinical case report and literature review of the on the biliary-duct hamartoma is presented. BACKGROUND: The biliary hamartoma is a rare hepatic lesion described for the first time in 1918 by Von Meyenburg. It is consistent with biliary duct deformity and disorganization, forming cystic structures varying in sizes. METHODS: The patient is a 44-year-old female who had an ultrasonogram that showing disseminated hepatic lesions, which rendered an irregular shape to the viscera. An abdominal CT scan corroborated this hepatic lesion that appeared as multiple and low density in cystic form, disseminated through the entire organ. This study also showed a pelvic lesion in the left ligament of the uterus. The images were interpreted as malignant left ovaric tumor with hepatic metastases. The patient was taken to exploratory laparotomy. Liver biopsies and radical hysterectomy were performed. RESULTS: The frozen sections were reported as negative for malignancy and definitive diagnostic was biliary duct hamartoma and uterine myomatosis. CONCLUSIONS: The presence of biliary duct hamartoma causes diagnostic confusion and difficulty in the management of patients in that it appears to be liver metastases.


Assuntos
Neoplasias dos Ductos Biliares/diagnóstico , Ductos Biliares Intra-Hepáticos , Hamartoma/diagnóstico , Adulto , Feminino , Humanos
18.
J Infect Dis ; 180(3): 876-9, 1999 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-10438384

RESUMO

To examine risk factors for human T cell lymphotropic virus type II (HTLV-II) infection, a case-control study was conducted among the Guaymi Indians of Panama. In females, HTLV-II seropositivity was associated with early sexual intercourse (15 years; odds ratio [OR], 2.50; 95% confidence interval [CI], 1.11-6.14) and number of lifetime sex partners. One partner increased risk of seropositivity by 30% (OR, 1.30; CI, 1.05-1.64), and risk increased with number of partners. Similar risk was associated with number of long-term sexual relationships. Among males, intercourse with prostitutes was associated with HTLV-II seropositivity (OR, 1.68; CI, 1.04-2.72). These data support a role for sexual transmission in HTLV-II infection. Association of seropositivity with primary residence in a traditional village (OR, 3.75; CI, 1.02-15.38) and lack of formal education (0 vs. >6 years [OR, 3.89; CI, 1.67-9.82]) observed in males may reflect differences in sexual practices associated with acculturation.


Assuntos
Infecções por HTLV-II/epidemiologia , Indígenas Centro-Americanos , Comportamento Sexual , Adolescente , Adulto , Criança , Feminino , Infecções por HTLV-II/transmissão , Humanos , Masculino , Panamá/epidemiologia , Fatores de Risco , Assunção de Riscos , Fatores Sexuais , Trabalho Sexual
19.
Rev. méd. Panamá ; 23(2): 15-19, sept. 1998.
Artigo em Espanhol | LILACS | ID: lil-409818

RESUMO

Myasthenia Gravis is an infrequent disease. Diagnosis and treatment must be done early to avoid high morbidity that can compromise patients lives. Nine cases were identified during the eight year 1990-1997 at the Santo Tomas Hospital of Panama city but one had to be excluded because he refused treatment. Most of the patients (7/8) had symptoms for more than 3 months. The diagnosis of Myasthenia Gravis requires a high index of suspicion and the clinical impressión must be confirmed by various diagnostic studies that include the edrophonium test, the repetitive stimulation test, the therapeutic test with pyridostigmine, the determination of acetylcholine anti-receptor antibodies and a CT Scan of the thorax. Medical treatment consists mainly of anticholinesterase agents and surgical treatment consists of thymectomy by means of an extended transternal ablation. Operative results were excellent, seven out of eight improved


Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Pessoa de Meia-Idade , Miastenia Gravis/diagnóstico , Brometo de Piridostigmina/uso terapêutico , Distribuição por Idade , Inibidores da Colinesterase/uso terapêutico , Miastenia Gravis/tratamento farmacológico , Miastenia Gravis/cirurgia , Timectomia
20.
Rev. méd. Panamá ; 23(1): 41-46, Jan.-May 1998.
Artigo em Espanhol | LILACS | ID: lil-409821

RESUMO

The Human T-Cell lymphotropic virus type I (HTLV-I) is endemic in the Caribbean basin, Japan, Central Africa and South Pacific. It as been associated to Lymphoma-Leukemia of Adult T-Cells (ATLL) and a progressive spastic paraparesis (TSP/HAM). The nationwide seroprevalence of Panama is of 1-2%. We report a case of a 73 year old male, albino, single, patient, Panamanian descendent from Jamaican immigrants who presented a skin disorder which started 1 year ago, characterized by the appearance of infiltrative, intensely pruritic papules, nodules and a non exfoliative erythroderna involving face, neck, trunk and extremities. He also had painless enlarged cervical lymph nodes, non tender hepatomegaly. Laboratory studies revealed a keukocyte count of 128,000/ml wit 67% atypical lymphocytes, serum calcium was 12.5 mg/dl, DL in 583 UNI, [quot ]flower cells[quot ] and atypical lymphocytes with hyperlobulated nuclear contour was observed in the peripheral blood smear, seropositivity to TLV-I detected by enzyme-linked immunosorbent assay (Elisa) and confirmed by Western blot assay. The skin biopsy shows a bandlike dermal infiltrates of atypical lymphoid cells with epidermotropism and Pautrier's microabscesses. Once the treatment was initiated with prednisone, cyclophosphamide, and systemic antibiotics for a bronchopneumonic process most of the cutaneous lesions cleared up although the clinical condition of our patient became progressively worse and died after a acute renal failure and a lower gastrointestinal bleeding. In 1986, the tree first cases of ATLL were identified in Panama, there has not been apparently new cases reported until now


Assuntos
Humanos , Masculino , Idoso , Leucemia-Linfoma de Células T do Adulto/patologia , Neoplasias Cutâneas/patologia
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