Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 60
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Nature ; 604(7906): 451-456, 2022 04.
Artigo em Inglês | MEDLINE | ID: mdl-35444318

RESUMO

The ability to engineer parallel, programmable operations between desired qubits within a quantum processor is key for building scalable quantum information systems1,2. In most state-of-the-art approaches, qubits interact locally, constrained by the connectivity associated with their fixed spatial layout. Here we demonstrate a quantum processor with dynamic, non-local connectivity, in which entangled qubits are coherently transported in a highly parallel manner across two spatial dimensions, between layers of single- and two-qubit operations. Our approach makes use of neutral atom arrays trapped and transported by optical tweezers; hyperfine states are used for robust quantum information storage, and excitation into Rydberg states is used for entanglement generation3-5. We use this architecture to realize programmable generation of entangled graph states, such as cluster states and a seven-qubit Steane code state6,7. Furthermore, we shuttle entangled ancilla arrays to realize a surface code state with thirteen data and six ancillary qubits8 and a toric code state on a torus with sixteen data and eight ancillary qubits9. Finally, we use this architecture to realize a hybrid analogue-digital evolution2 and use it for measuring entanglement entropy in quantum simulations10-12, experimentally observing non-monotonic entanglement dynamics associated with quantum many-body scars13,14. Realizing a long-standing goal, these results provide a route towards scalable quantum processing and enable applications ranging from simulation to metrology.

2.
Nature ; 595(7866): 227-232, 2021 07.
Artigo em Inglês | MEDLINE | ID: mdl-34234334

RESUMO

Motivated by far-reaching applications ranging from quantum simulations of complex processes in physics and chemistry to quantum information processing1, a broad effort is currently underway to build large-scale programmable quantum systems. Such systems provide insights into strongly correlated quantum matter2-6, while at the same time enabling new methods for computation7-10 and metrology11. Here we demonstrate a programmable quantum simulator based on deterministically prepared two-dimensional arrays of neutral atoms, featuring strong interactions controlled by coherent atomic excitation into Rydberg states12. Using this approach, we realize a quantum spin model with tunable interactions for system sizes ranging from 64 to 256 qubits. We benchmark the system by characterizing high-fidelity antiferromagnetically ordered states and demonstrating quantum critical dynamics consistent with an Ising quantum phase transition in (2 + 1) dimensions13. We then create and study several new quantum phases that arise from the interplay between interactions and coherent laser excitation14, experimentally map the phase diagram and investigate the role of quantum fluctuations. Offering a new lens into the study of complex quantum matter, these observations pave the way for investigations of exotic quantum phases, non-equilibrium entanglement dynamics and hardware-efficient realization of quantum algorithms.

3.
Nat Commun ; 12(1): 3905, 2021 06 23.
Artigo em Inglês | MEDLINE | ID: mdl-34162847

RESUMO

Image-like data from quantum systems promises to offer greater insight into the physics of correlated quantum matter. However, the traditional framework of condensed matter physics lacks principled approaches for analyzing such data. Machine learning models are a powerful theoretical tool for analyzing image-like data including many-body snapshots from quantum simulators. Recently, they have successfully distinguished between simulated snapshots that are indistinguishable from one and two point correlation functions. Thus far, the complexity of these models has inhibited new physical insights from such approaches. Here, we develop a set of nonlinearities for use in a neural network architecture that discovers features in the data which are directly interpretable in terms of physical observables. Applied to simulated snapshots produced by two candidate theories approximating the doped Fermi-Hubbard model, we uncover that the key distinguishing features are fourth-order spin-charge correlators. Our approach lends itself well to the construction of simple, versatile, end-to-end interpretable architectures, thus paving the way for new physical insights from machine learning studies of experimental and numerical data.

4.
FEBS J ; 287(21): 4612-4640, 2020 11.
Artigo em Inglês | MEDLINE | ID: mdl-32133789

RESUMO

In mammalian cells, one-third of all polypeptides are integrated into the membrane or translocated into the lumen of the endoplasmic reticulum (ER) via the Sec61 channel. While the Sec61 complex facilitates ER import of most precursor polypeptides, the Sec61-associated Sec62/Sec63 complex supports ER import in a substrate-specific manner. So far, mainly posttranslationally imported precursors and the two cotranslationally imported precursors of ERj3 and prion protein were found to depend on the Sec62/Sec63 complex in vitro. Therefore, we determined the rules for engagement of Sec62/Sec63 in ER import in intact human cells using a recently established unbiased proteomics approach. In addition to confirming ERj3, we identified 22 novel Sec62/Sec63 substrates under these in vivo-like conditions. As a common feature, those previously unknown substrates share signal peptides (SP) with comparatively longer but less hydrophobic hydrophobic region of SP and lower carboxy-terminal region of SP (C-region) polarity. Further analyses with four substrates, and ERj3 in particular, revealed the combination of a slowly gating SP and a downstream translocation-disruptive positively charged cluster of amino acid residues as decisive for the Sec62/Sec63 requirement. In the case of ERj3, these features were found to be responsible for an additional immunoglobulin heavy-chain binding protein (BiP) requirement and to correlate with sensitivity toward the Sec61-channel inhibitor CAM741. Thus, the human Sec62/Sec63 complex may support Sec61-channel opening for precursor polypeptides with slowly gating SPs by direct interaction with the cytosolic amino-terminal peptide of Sec61α or via recruitment of BiP and its interaction with the ER-lumenal loop 7 of Sec61α. These novel insights into the mechanism of human ER protein import contribute to our understanding of the etiology of SEC63-linked polycystic liver disease. DATABASES: The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository (http://www.ebi.ac.uk/pride/archive/projects/Identifiers) with the dataset identifiers: PXD008178, PXD011993, and PXD012078. Supplementary information was deposited at Mendeley Data (https://data.mendeley.com/datasets/6s5hn73jcv/2).


Assuntos
Retículo Endoplasmático/metabolismo , Proteínas de Membrana Transportadoras/metabolismo , Chaperonas Moleculares/metabolismo , Sinais Direcionadores de Proteínas , Proteínas de Ligação a RNA/metabolismo , Animais , Células HEK293 , Proteínas de Choque Térmico HSP40/metabolismo , Células HeLa , Humanos , Proteínas de Membrana Transportadoras/genética , Camundongos Endogâmicos C57BL , Camundongos Knockout , Chaperonas Moleculares/genética , Transporte Proteico , Proteoma/metabolismo , Proteômica/métodos , Proteínas de Ligação a RNA/genética , Canais de Translocação SEC/genética , Canais de Translocação SEC/metabolismo , Especificidade por Substrato
5.
Phys Rev Lett ; 123(23): 230504, 2019 Dec 06.
Artigo em Inglês | MEDLINE | ID: mdl-31868463

RESUMO

We demonstrate quantum many-body state reconstruction from experimental data generated by a programmable quantum simulator by means of a neural-network model incorporating known experimental errors. Specifically, we extract restricted Boltzmann machine wave functions from data produced by a Rydberg quantum simulator with eight and nine atoms in a single measurement basis and apply a novel regularization technique to mitigate the effects of measurement errors in the training data. Reconstructions of modest complexity are able to capture one- and two-body observables not accessible to experimentalists, as well as more sophisticated observables such as the Rényi mutual information. Our results open the door to integration of machine learning architectures with intermediate-scale quantum hardware.

6.
Phys Rev Lett ; 123(17): 170503, 2019 Oct 25.
Artigo em Inglês | MEDLINE | ID: mdl-31702233

RESUMO

We report the implementation of universal two- and three-qubit entangling gates on neutral-atom qubits encoded in long-lived hyperfine ground states. The gates are mediated by excitation to strongly interacting Rydberg states and are implemented in parallel on several clusters of atoms in a one-dimensional array of optical tweezers. Specifically, we realize the controlled-phase gate, enacted by a novel, fast protocol involving only global coupling of two qubits to Rydberg states. We benchmark this operation by preparing Bell states with fidelity F≥95.0(2)%, and extract gate fidelity ≥97.4(3)%, averaged across five atom pairs. In addition, we report a proof-of-principle implementation of the three-qubit Toffoli gate, in which two control atoms simultaneously constrain the behavior of one target atom. These experiments demonstrate key ingredients for high-fidelity quantum information processing in a scalable neutral-atom platform.

7.
Nature ; 573(7774): 385-389, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-31485075

RESUMO

Phase transitions are driven by collective fluctuations of a system's constituents that emerge at a critical point1. This mechanism has been extensively explored for classical and quantum systems in equilibrium, whose critical behaviour is described by the general theory of phase transitions. Recently, however, fundamentally distinct phase transitions have been discovered for out-of-equilibrium quantum systems, which can exhibit critical behaviour that defies this description and is not well understood1. A paradigmatic example is the many-body localization (MBL) transition, which marks the breakdown of thermalization in an isolated quantum many-body system as its disorder increases beyond a critical value2-11. Characterizing quantum critical behaviour in an MBL system requires probing its entanglement over space and time4,5,7, which has proved experimentally challenging owing to stringent requirements on quantum state preparation and system isolation. Here we observe quantum critical behaviour at the MBL transition in a disordered Bose-Hubbard system and characterize its entanglement via its multi-point quantum correlations. We observe the emergence of strong correlations, accompanied by the onset of anomalous diffusive transport throughout the system, and verify their critical nature by measuring their dependence on the system size. The correlations extend to high orders in the quantum critical regime and appear to form via a sparse network of many-body resonances that spans the entire system12,13. Our results connect the macroscopic phenomenology of the transition to the system's microscopic structure of quantum correlations, and they provide an essential step towards understanding criticality and universality in non-equilibrium systems1,7,13.


Assuntos
Modelos Teóricos , Teoria Quântica , Partículas Elementares , Termodinâmica
8.
Science ; 365(6450): 251-256, 2019 07 19.
Artigo em Inglês | MEDLINE | ID: mdl-31320533

RESUMO

Understanding strongly correlated quantum many-body states is one of the most difficult challenges in modern physics. For example, there remain fundamental open questions on the phase diagram of the Hubbard model, which describes strongly correlated electrons in solids. In this work, we realize the Hubbard Hamiltonian and search for specific patterns within the individual images of many realizations of strongly correlated ultracold fermions in an optical lattice. Upon doping a cold-atom antiferromagnet, we find consistency with geometric strings, entities that may explain the relationship between hole motion and spin order, in both pattern-based and conventional observables. Our results demonstrate the potential for pattern recognition to provide key insights into cold-atom quantum many-body systems.

9.
Opt Lett ; 44(12): 3178-3181, 2019 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-31199410

RESUMO

In this Letter, to the best of our knowledge, we report a new method to generate uniform large-scale optical focus arrays (LOFAs). By identifying and removing undesired phase rotation in the iterative Fourier transform algorithm (IFTA), our approach rapidly produces computer-generated holograms of highly uniform LOFAs. The new algorithm also shows a faster compensation of system-induced LOFA intensity inhomogeneity than the conventional IFTA. After only three adaptive correction steps, we demonstrate LOFAs consisting of O(103) optical foci with an intensity uniformity greater than 98%.

10.
Science ; 364(6437): 256-260, 2019 04 19.
Artigo em Inglês | MEDLINE | ID: mdl-31000657

RESUMO

An interacting quantum system that is subject to disorder may cease to thermalize owing to localization of its constituents, thereby marking the breakdown of thermodynamics. The key to understanding this phenomenon lies in the system's entanglement, which is experimentally challenging to measure. We realize such a many-body-localized system in a disordered Bose-Hubbard chain and characterize its entanglement properties through particle fluctuations and correlations. We observe that the particles become localized, suppressing transport and preventing the thermalization of subsystems. Notably, we measure the development of nonlocal correlations, whose evolution is consistent with a logarithmic growth of entanglement entropy, the hallmark of many-body localization. Our work experimentally establishes many-body localization as a qualitatively distinct phenomenon from localization in noninteracting, disordered systems.

11.
Nature ; 568(7751): 207-211, 2019 04.
Artigo em Inglês | MEDLINE | ID: mdl-30936552

RESUMO

Quantum phase transitions (QPTs) involve transformations between different states of matter that are driven by quantum fluctuations1. These fluctuations play a dominant part in the quantum critical region surrounding the transition point, where the dynamics is governed by the universal properties associated with the QPT. Although time-dependent phenomena associated with classical, thermally driven phase transitions have been extensively studied in systems ranging from the early Universe to Bose-Einstein condensates2-5, understanding critical real-time dynamics in isolated, non-equilibrium quantum systems remains a challenge6. Here we use a Rydberg atom quantum simulator with programmable interactions to study the quantum critical dynamics associated with several distinct QPTs. By studying the growth of spatial correlations when crossing the QPT, we experimentally verify the quantum Kibble-Zurek mechanism (QKZM)7-9 for an Ising-type QPT, explore scaling universality and observe corrections beyond QKZM predictions. This approach is subsequently used to measure the critical exponents associated with chiral clock models10,11, providing new insights into exotic systems that were not previously understood and opening the door to precision studies of critical phenomena, simulations of lattice gauge theories12,13 and applications to quantum optimization14,15.

12.
Phys Rev Lett ; 121(12): 123603, 2018 Sep 21.
Artigo em Inglês | MEDLINE | ID: mdl-30296143

RESUMO

Individual neutral atoms excited to Rydberg states are a promising platform for quantum simulation and quantum information processing. However, experimental progress to date has been limited by short coherence times and relatively low gate fidelities associated with such Rydberg excitations. We report progress towards high-fidelity quantum control of Rydberg-atom qubits. Enabled by a reduction in laser phase noise, our approach yields a significant improvement in coherence properties of individual qubits. We further show that this high-fidelity control extends to the multi-particle case by preparing a two-atom entangled state with a fidelity exceeding 0.97(3), and extending its lifetime with a two-atom dynamical decoupling protocol. These advances open up new prospects for scalable quantum simulation and quantum computation with neutral atoms.

13.
Phys Rev Lett ; 120(24): 243201, 2018 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-29956952

RESUMO

Accessing new regimes in quantum simulation requires the development of new techniques for quantum state preparation. We demonstrate the quantum state engineering of a strongly correlated many-body state of the two-component repulsive Fermi-Hubbard model on a square lattice. Our scheme makes use of an ultralow entropy doublon band insulator created through entropy redistribution. After isolating the band insulator, we change the underlying potential to expand it into a half-filled system. The final many-body state realized shows strong antiferromagnetic correlations and a temperature below the exchange energy. We observe an increase in entropy, which we find is likely caused by the many-body physics in the last step of the scheme. This technique is promising for low-temperature studies of cold-atom-based lattice models.

14.
Biomol Concepts ; 9(1): 53-63, 2018 May 19.
Artigo em Inglês | MEDLINE | ID: mdl-29779013

RESUMO

Treatment with analogues of the SERCA-inhibitor Thapsigargin is a promising new approach for a wide variety of cancer entities. However, our previous studies on various tumor cells suggested resistance of SEC62 over-expressing tumors to this treatment. Therefore, we proposed the novel concept that e.g. lung-, prostate-, and thyroid-cancer patients should be tested for SEC62 over-expression, and developed a novel therapeutic strategy for a combinatorial treatment of SEC62 over-expressing tumors. The latter was based on the observations that treatment of SEC62 over-expressing tumor cells with SEC62-targeting siRNAs showed less resistance to Thapsigargin as well as a reduction in migratory potential and that the siRNA effects can be mimicked by the Calmodulin antagonist Trifluoperazine. Therefore, the combinatorial treatment of SEC62 over-expressing tumors was proposed to involve Thapsigargin and Trifluoperazine. Here, we addressed the impact of Thapsigargin and Trifluoperazine in separate and combined treatments of heterotopic tumors, induced by inoculation of human hypopharyngeal squamous cell carcinoma (FaDu)-cells into the mouse flank. Seeding of the tumor cells and/or their growth rate were significantly reduced by all three treatments, suggesting Trifluoperazine is a small molecule to be considered for future therapeutic strategies for patients, suffering from Sec62-overproducing tumors.


Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Carcinoma de Células Escamosas/tratamento farmacológico , Inibidores Enzimáticos/uso terapêutico , Neoplasias de Cabeça e Pescoço/tratamento farmacológico , Neoplasias Hipofaríngeas/tratamento farmacológico , Proteínas de Membrana Transportadoras/metabolismo , Tapsigargina/uso terapêutico , Trifluoperazina/uso terapêutico , Animais , Calmodulina/antagonistas & inibidores , Carcinoma de Células Escamosas/genética , Linhagem Celular Tumoral , Proliferação de Células , Inibidores Enzimáticos/sangue , Neoplasias de Cabeça e Pescoço/genética , Humanos , Neoplasias Hipofaríngeas/genética , Camundongos , ATPases Transportadoras de Cálcio do Retículo Sarcoplasmático/antagonistas & inibidores , Carcinoma de Células Escamosas de Cabeça e Pescoço , Tapsigargina/sangue , Trifluoperazina/sangue
15.
Nature ; 551(7682): 579-584, 2017 11 29.
Artigo em Inglês | MEDLINE | ID: mdl-29189778

RESUMO

Controllable, coherent many-body systems can provide insights into the fundamental properties of quantum matter, enable the realization of new quantum phases and could ultimately lead to computational systems that outperform existing computers based on classical approaches. Here we demonstrate a method for creating controlled many-body quantum matter that combines deterministically prepared, reconfigurable arrays of individually trapped cold atoms with strong, coherent interactions enabled by excitation to Rydberg states. We realize a programmable Ising-type quantum spin model with tunable interactions and system sizes of up to 51 qubits. Within this model, we observe phase transitions into spatially ordered states that break various discrete symmetries, verify the high-fidelity preparation of these states and investigate the dynamics across the phase transition in large arrays of atoms. In particular, we observe robust many-body dynamics corresponding to persistent oscillations of the order after a rapid quantum quench that results from a sudden transition across the phase boundary. Our method provides a way of exploring many-body phenomena on a programmable quantum simulator and could enable realizations of new quantum algorithms.

16.
Nature ; 546(7659): 519-523, 2017 06 21.
Artigo em Inglês | MEDLINE | ID: mdl-28640260

RESUMO

The interplay between magnetic fields and interacting particles can lead to exotic phases of matter that exhibit topological order and high degrees of spatial entanglement. Although these phases were discovered in a solid-state setting, recent innovations in systems of ultracold neutral atoms-uncharged atoms that do not naturally experience a Lorentz force-allow the synthesis of artificial magnetic, or gauge, fields. This experimental platform holds promise for exploring exotic physics in fractional quantum Hall systems, owing to the microscopic control and precision that is achievable in cold-atom systems. However, so far these experiments have mostly explored the regime of weak interactions, which precludes access to correlated many-body states. Here, through microscopic atomic control and detection, we demonstrate the controlled incorporation of strong interactions into a two-body system with a chiral band structure. We observe and explain the way in which interparticle interactions induce chirality in the propagation dynamics of particles in a ladder-like, real-space lattice governed by the interacting Harper-Hofstadter model, which describes lattice-confined, coherently mobile particles in the presence of a magnetic field. We use a bottom-up strategy to prepare interacting chiral quantum states, thus circumventing the challenges of a top-down approach that begins with a many-body system, the size of which can hinder the preparation of controlled states. Our experimental platform combines all of the necessary components for investigating highly entangled topological states, and our observations provide a benchmark for future experiments in the fractional quantum Hall regime.

17.
Nature ; 545(7655): 462-466, 2017 05 24.
Artigo em Inglês | MEDLINE | ID: mdl-28541324

RESUMO

Exotic phenomena in systems with strongly correlated electrons emerge from the interplay between spin and motional degrees of freedom. For example, doping an antiferromagnet is expected to give rise to pseudogap states and high-temperature superconductors. Quantum simulation using ultracold fermions in optical lattices could help to answer open questions about the doped Hubbard Hamiltonian, and has recently been advanced by quantum gas microscopy. Here we report the realization of an antiferromagnet in a repulsively interacting Fermi gas on a two-dimensional square lattice of about 80 sites at a temperature of 0.25 times the tunnelling energy. The antiferromagnetic long-range order manifests through the divergence of the correlation length, which reaches the size of the system, the development of a peak in the spin structure factor and a staggered magnetization that is close to the ground-state value. We hole-dope the system away from half-filling, towards a regime in which complex many-body states are expected, and find that strong magnetic correlations persist at the antiferromagnetic ordering vector up to dopings of about 15 per cent. In this regime, numerical simulations are challenging and so experiments provide a valuable benchmark. Our results demonstrate that microscopy of cold atoms in optical lattices can help us to understand the low-temperature Fermi-Hubbard model.

18.
Int J Med Microbiol ; 307(2): 116-125, 2017 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-28117265

RESUMO

Staphyloccocus aureus is a major human pathogen and a common cause for superficial and deep seated wound infections. The pathogen is equipped with a large arsenal of virulence factors, which facilitate attachment to various eukaryotic cell structures and modulate the host immune response. One of these factors is the extracellular adherence protein Eap, a member of the "secretable expanded repertoire adhesive molecules" (SERAM) protein family that possesses adhesive and immune modulatory properties. The secreted protein was previously shown to impair wound healing by interfering with host defense and neovascularization. However, its impact on keratinocyte proliferation and migration, two major steps in the re-epithelialization process of wounds, is not known. Here, we report that Eap affects the proliferation and migration capacities of keratinocytes by altering their morphology and adhesive properties. In particular, treatment of non-confluent HaCaT cell cultures with Eap resulted in cell morphology changes as well as a significant reduction in cell proliferation and migration. Eap-treated HaCaT cells changed their appearance from an oblong via a trapezoid to an astral-like shape, accompanied by decreases in cell volume and cell stiffness, and exhibited significantly increased cell adhesion. Eap had a similar influence on endothelial and cancer cells, indicative for a general effect of Eap on eukaryotic cell morphology and functions. Specifically, Eap was found to interfere with growth factor-stimulated activation of the mitogen-activated protein kinase (MAPK) pathway that is known to be responsible for cell shape modulation, induction of proliferation and migration of epithelial cells. Western blot analyses revealed that Eap blocked the phosphorylation of extracellular signal-regulated kinase 1 and 2 (Erk1/2) in keratinocyte growth factor (KGF)-stimulated HaCaT cells. Together, these data add another antagonistic mechanism of Eap in wound healing, whereby the bacterial protein interferes with keratinocyte migration and proliferation.


Assuntos
Proteínas de Bactérias/metabolismo , Movimento Celular/efeitos dos fármacos , Proliferação de Células/efeitos dos fármacos , Queratinócitos/efeitos dos fármacos , Queratinócitos/fisiologia , Proteínas de Ligação a RNA/metabolismo , Staphylococcus aureus/patogenicidade , Adesão Celular/efeitos dos fármacos , Linhagem Celular , Células Endoteliais/efeitos dos fármacos , Células Epiteliais/efeitos dos fármacos , Humanos , Queratinócitos/citologia , Transdução de Sinais/efeitos dos fármacos , Cicatrização/efeitos dos fármacos
20.
Oncotarget ; 8(3): 4922-4934, 2017 Jan 17.
Artigo em Inglês | MEDLINE | ID: mdl-28002801

RESUMO

Chromosome 3q26 amplification represents a frequent alteration in head and neck squamous cell carcinomas (HNSCCs). Overexpression of 3q26 encoded genes SEC62 and SOX2 was detected in various cancers, including HNSCCs, indicating their potential function as oncogenes. In our study, we elucidated the function of SEC62 and SOX2 in HNSCC patients, with a main focus on their effect on lymphatic metastasis and patient survival. We analyzed SEC62 and SOX2 expression in tissue specimens from 65 HNSCC patients and 29 patients with cervical cancer of unknown primary (CUP); a higher SEC62 and lower SOX2 expression was observed in the lymph node metastases from HNSCC patients compared with the respective primary tumor. Lymph node metastases from CUP patients showed higher SEC62 and lower SOX2 expression compared with lymph node metastases from HNSCC patients. When proceeding from the N1 to the N3 stage, SEC62 expression in the lymph node metastases showed an increase and SOX2 expression showed a decrease. Moreover, both genes showed a highly significant relevance as prognostic biomarkers, with the worst prognosis for patients with high SEC62 and low SOX2 expression levels. In functional analyses, knockdown of SEC62 resulted in an inhibition of HNSCC cell migration while, conversely, SEC62 and SOX2 overexpression stimulated cell migration. Taken together, our study showed that the expression of the 3q oncogenes SEC62 and SOX2 affects lymphatic metastasis and cell migration in HNSCC and CUP patients and has a high prognostic relevance in these diseases.


Assuntos
Carcinoma de Células Escamosas/patologia , Cromossomos Humanos Par 3/genética , Neoplasias de Cabeça e Pescoço/patologia , Proteínas de Membrana Transportadoras/metabolismo , Fatores de Transcrição SOXB1/metabolismo , Idoso , Biomarcadores Tumorais/metabolismo , Carcinoma de Células Escamosas/genética , Carcinoma de Células Escamosas/metabolismo , Linhagem Celular Tumoral , Movimento Celular , Proliferação de Células , Cromossomos Humanos Par 3/metabolismo , Feminino , Regulação Neoplásica da Expressão Gênica , Neoplasias de Cabeça e Pescoço/genética , Neoplasias de Cabeça e Pescoço/metabolismo , Humanos , Metástase Linfática , Masculino , Proteínas de Membrana Transportadoras/genética , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Prognóstico , Fatores de Transcrição SOXB1/genética , Carcinoma de Células Escamosas de Cabeça e Pescoço , Análise de Sobrevida
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...