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1.
Vopr Virusol ; 63(5): 218-223, 2018.
Artigo em Russo | MEDLINE | ID: mdl-30550098

RESUMO

Increased protease activity and a significant amount of granzyme B were observed in in organs of mice infected with acute herpes simplex virus HSV-1 with the introduction of Stimforte (100 or 250 µg/mouse). Thus, this drug activates killer cells, which play an extremely important role in the suppression of HSV-1 infection. Although the administration of Stimforte (100 µg/mouse) to intact mice results in the activation of IFN-ß production and does not activate the production of IFN-λ, Stimforte administration to animals infected with HSV-1 reduces production of IFN-ß in serum, brain and lungs, whereas the production of IFN-λ considerably increases as the result of administration of 100 µg/mouse of Stimforte.


Assuntos
Granzimas/genética , Infecções por Herpesviridae/tratamento farmacológico , Herpesvirus Humano 1/efeitos dos fármacos , Pulmão/efeitos dos fármacos , Compostos Orgânicos/farmacologia , Animais , Encéfalo/efeitos dos fármacos , Encéfalo/metabolismo , Encéfalo/virologia , Regulação Viral da Expressão Gênica/efeitos dos fármacos , Granzimas/metabolismo , Infecções por Herpesviridae/sangue , Infecções por Herpesviridae/metabolismo , Infecções por Herpesviridae/virologia , Herpesvirus Humano 1/patogenicidade , Humanos , Interferon beta/sangue , Interferon beta/genética , Interferon beta/metabolismo , Interferon gama/sangue , Interferon gama/genética , Interferon gama/metabolismo , Células Matadoras Naturais/efeitos dos fármacos , Pulmão/metabolismo , Pulmão/virologia , Camundongos , Compostos Orgânicos/uso terapêutico , Replicação Viral/efeitos dos fármacos
2.
Dokl Biol Sci ; 477(1): 219-222, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-29299800

RESUMO

Stimforte, an immune response-stimulating preparation, is active with respect to hepatitis C virus (HCV) and herpes simplex virus type I (HSV-1). The effects of Stimforte in animals infected with either HCV or HSV-1 are fundamentally different. In mice with acute herpes virus infection, Stimforte administration leads to a higher activity of natural killer cells and cytotoxic lymphocytes, and the amount of interferon (IFN) λ grows. In mice infected with HCV, Stimforte administration results in a significant increase in IFN-ß but not IFN-λ in blood and affected organs. Stimforte has been found to affect directly HCV reproduction that causes the infected cell death, but it does not affect HSV-1 reproduction in the Vero cells (V).


Assuntos
Antivirais/farmacologia , Hepatite C/tratamento farmacológico , Herpes Simples/tratamento farmacológico , Fatores Imunológicos/farmacologia , Animais , Antivirais/administração & dosagem , Antivirais/uso terapêutico , Chlorocebus aethiops , Hepacivirus/efeitos dos fármacos , Hepacivirus/fisiologia , Herpesvirus Humano 1/efeitos dos fármacos , Herpesvirus Humano 1/fisiologia , Fatores Imunológicos/administração & dosagem , Fatores Imunológicos/uso terapêutico , Interferons/metabolismo , Células Matadoras Naturais/efeitos dos fármacos , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Células Vero , Replicação Viral/efeitos dos fármacos
3.
Antibiot Khimioter ; 59(3-4): 16-21, 2014.
Artigo em Russo | MEDLINE | ID: mdl-25300117

RESUMO

Substances with gender action on immunity were detected in water soluble hydrolised matter from reptile carcases. The gender action was shown on isolated blood neutrophils, whole blood and in vivo by the antiviral activity on experimental animals, contaminated with three types of viruses: Herpes simplex type 1, the virus of encephalomyocarditis and the virus of hepatitis of mice. The possible mechanism of the inhibitory action on the male immunity was associated with the protein kinase cascade, including protein kinase C, activated by phorbolmyristate in the cells of the immune system.


Assuntos
Misturas Complexas/farmacologia , Imunidade Inata/efeitos dos fármacos , NADPH Oxidases/antagonistas & inibidores , Neutrófilos/efeitos dos fármacos , Proteína Quinase C/antagonistas & inibidores , Carga Viral/efeitos dos fármacos , Animais , Infecções por Cardiovirus/tratamento farmacológico , Infecções por Cardiovirus/virologia , Misturas Complexas/isolamento & purificação , Infecções por Coronavirus/tratamento farmacológico , Infecções por Coronavirus/virologia , Vírus da Encefalomiocardite/efeitos dos fármacos , Vírus da Encefalomiocardite/fisiologia , Feminino , Hepatite Viral Animal/tratamento farmacológico , Hepatite Viral Animal/virologia , Herpes Simples/tratamento farmacológico , Herpes Simples/virologia , Herpesvirus Humano 1/efeitos dos fármacos , Herpesvirus Humano 1/fisiologia , Humanos , Masculino , Camundongos , Vírus da Hepatite Murina/efeitos dos fármacos , Vírus da Hepatite Murina/fisiologia , NADPH Oxidases/metabolismo , Neutrófilos/citologia , Neutrófilos/imunologia , Proteína Quinase C/metabolismo , Répteis/metabolismo , Fatores Sexuais
4.
Eksp Klin Farmakol ; 77(11): 16-9, 2014.
Artigo em Russo | MEDLINE | ID: mdl-25668942

RESUMO

Peculiarities of the kinetics of accumulation and duration of circulation of three types of interferon under the action of acridonacetic acid salts have been studied. Optimum doses of meglumine salt of acridonacetic acid are established, which ensure efficient and consistent induction of three interferon types, ensuring their prolonged circulation in the blood.


Assuntos
Acridonas/farmacologia , Citocinas/biossíntese , Indutores de Interferon/farmacologia , Interferon-alfa/biossíntese , Interferon gama/biossíntese , Meglumina/análogos & derivados , Meglumina/farmacologia , Acridonas/química , Administração Oral , Animais , Citocinas/sangue , Feminino , Interferon-alfa/sangue , Interferon gama/sangue , Meglumina/química , Camundongos , Camundongos Endogâmicos CBA
5.
Eksp Klin Farmakol ; 76(7): 39-42, 2013.
Artigo em Russo | MEDLINE | ID: mdl-24006616

RESUMO

The article describes the clinical forms of chronic hyperplastic laryngitis, characterized by persistent and recurrent course, a tendency to the formation of oncological pathology, at the expense of hyperplastic changes in the larynx, leading to a malignancy of the inflammatory process. It was demonstrated the bacterization of larynx by Epstein-Barr virus (EBV) and Mycoplasma in imbalance of system of interferon. Clinical recovery, depending on the clinical form of the disease, using cycloferon, was observed in 57.4% of patients. The inclusion in the complex of the medical support of chronic hyperplastic laryngitis inducer of interferon - cycloferon, provided the reduction of the number of relapses.


Assuntos
Acridinas/uso terapêutico , Infecções por Vírus Epstein-Barr/tratamento farmacológico , Hiperplasia/tratamento farmacológico , Indutores de Interferon/uso terapêutico , Laringite/tratamento farmacológico , Infecções por Mycoplasma/tratamento farmacológico , Anticorpos Antibacterianos/sangue , Anticorpos Antibacterianos/imunologia , Anticorpos Antivirais/sangue , Anticorpos Antivirais/imunologia , Doença Crônica , Infecções por Vírus Epstein-Barr/complicações , Infecções por Vírus Epstein-Barr/imunologia , Infecções por Vírus Epstein-Barr/patologia , Herpesvirus Humano 4/efeitos dos fármacos , Herpesvirus Humano 4/fisiologia , Humanos , Hiperplasia/complicações , Hiperplasia/imunologia , Hiperplasia/patologia , Interferon-alfa/sangue , Interferon-alfa/imunologia , Interferon gama/sangue , Interferon gama/imunologia , Laringite/complicações , Laringite/imunologia , Laringite/patologia , Laringe/efeitos dos fármacos , Laringe/imunologia , Laringe/patologia , Mycoplasma/efeitos dos fármacos , Mycoplasma/crescimento & desenvolvimento , Infecções por Mycoplasma/complicações , Infecções por Mycoplasma/imunologia , Infecções por Mycoplasma/patologia , Prevenção Secundária
6.
Antibiot Khimioter ; 58(5-6): 24-31, 2013.
Artigo em Russo | MEDLINE | ID: mdl-24757822

RESUMO

The clinical course of various forms of chronic laryngitis, including contact granulomas not only persistant and relapsing, but also inclined to oncologic pathology due to hyperplastic changes in the larynx resulting in malignization was described. Inhibition of the leukocyte interferon-synthesizing activity was observed in more than 88.1% of the subjects. Pathogenic viruses were isolated from 48.2% of the patients, EBV and mycoplasma prevailing. High direct correlation between chronic laryngitis and Herpes viruses was shown. The presence of three-component virus associations in the larynx mucosa was likely indicative of the bening process malignancy. The use of the interferon inductor cycloferon in the complex surgical and medicamentous management of chronic laryngitis was shown valid. The rate of the relapses lowered to 1.7 episodes a year.


Assuntos
Acridinas/uso terapêutico , Infecções por Vírus Epstein-Barr/terapia , Granuloma/terapia , Indutores de Interferon/uso terapêutico , Laringite/terapia , Infecções por Mycoplasma/terapia , Adulto , Doença Crônica , Coinfecção , Infecções por Vírus Epstein-Barr/imunologia , Infecções por Vírus Epstein-Barr/microbiologia , Infecções por Vírus Epstein-Barr/virologia , Granuloma/imunologia , Granuloma/microbiologia , Granuloma/virologia , Herpesvirus Humano 4/efeitos dos fármacos , Herpesvirus Humano 4/imunologia , Humanos , Laringite/imunologia , Laringite/microbiologia , Laringite/virologia , Laringe/efeitos dos fármacos , Laringe/imunologia , Laringe/microbiologia , Laringe/virologia , Mycoplasma/efeitos dos fármacos , Mycoplasma/imunologia , Infecções por Mycoplasma/imunologia , Infecções por Mycoplasma/microbiologia , Infecções por Mycoplasma/virologia , Prevenção Secundária , Resultado do Tratamento
7.
Antibiot Khimioter ; 58(7-8): 17-22, 2013.
Artigo em Russo | MEDLINE | ID: mdl-24757829

RESUMO

The data on the efficacy of cycloferon as an agents of antirelapsing therapy in management of 123 patients with chronic hyperplastic sinusitis are presented. The drug induction of endogenous interferons was validated by the properties of the local mucosal immunity, virus invasion and virus persistence in the nasal an d accessory nasal sinuses mucosa, as well as by different levels ofthe interferon production deficiency. The clinical efficacy was stated in 53% of the cases. The relapses were recorded in 13.1% of the patients treated with cycloferon vs. 33.3% of the patients under the local corticosteroid therapy.


Assuntos
Acridinas/uso terapêutico , Imunidade nas Mucosas/efeitos dos fármacos , Indutores de Interferon/uso terapêutico , Mucosa Nasal/efeitos dos fármacos , Pólipos Nasais/tratamento farmacológico , Sinusite/tratamento farmacológico , Adolescente , Corticosteroides/uso terapêutico , Adulto , Idoso , Doença Crônica , Feminino , Humanos , Interferon-alfa/biossíntese , Interferon-alfa/imunologia , Interferon gama/biossíntese , Interferon gama/imunologia , Masculino , Pessoa de Meia-Idade , Mucosa Nasal/imunologia , Mucosa Nasal/patologia , Pólipos Nasais/imunologia , Pólipos Nasais/patologia , Testes de Função Respiratória , Prevenção Secundária , Sinusite/imunologia , Sinusite/patologia
9.
Antibiot Khimioter ; 54(3-4): 52-7, 2009.
Artigo em Russo | MEDLINE | ID: mdl-19711852

RESUMO

Cycloferon, a prospective interferon inductor, and the mechanism of its action were characterized. Its formulation for external use as liniment was developed. The pharmacotherapeutic effect of the drug in the treatment of paradontitis was shown. The drug efficacy in herpetic lesions of the mouth and lips mucosa was observed. The use of cycloferon in the treatment of the buccal mucosa affections in HIV-infected subjects was substantiated.


Assuntos
Acridinas/uso terapêutico , Indutores de Interferon/uso terapêutico , Doenças Maxilares/tratamento farmacológico , Doenças Periodontais/tratamento farmacológico , Estomatite Herpética/tratamento farmacológico , Acridinas/administração & dosagem , Administração Tópica , Humanos , Indutores de Interferon/administração & dosagem , Linimentos , Doenças Maxilares/microbiologia , Doenças Maxilares/virologia , Doenças Periodontais/microbiologia , Ensaios Clínicos Controlados Aleatórios como Assunto , Resultado do Tratamento
10.
Ross Fiziol Zh Im I M Sechenova ; 91(1): 46-52, 2005 Jan.
Artigo em Russo | MEDLINE | ID: mdl-15773579

RESUMO

Influence of a high-molecular compound capable of augmenting viscosity, namely: polyethylene oxide Polyox WSR-301, on hemodynamic parameters in rat mesenteric microvessels was investigated. A substantial decrease in the arteriolar hemodynamic resistance caused by the polymer was revealed. Special research has shown that this reaction is not connected with a vasodilatation and, therefore, is caused by a reduction in the "apparent" viscosity of the blood, i.e., it is a consequence of changed properties of the blood flow.


Assuntos
Viscosidade Sanguínea/efeitos dos fármacos , Intestinos/irrigação sanguínea , Polietilenoglicóis/farmacologia , Animais , Velocidade do Fluxo Sanguíneo/efeitos dos fármacos , Hemorreologia , Masculino , Artérias Mesentéricas/fisiologia , Veias Mesentéricas/fisiologia , Microcirculação/efeitos dos fármacos , Ratos , Ratos Wistar , Resistência Vascular/efeitos dos fármacos
11.
Artigo em Russo | MEDLINE | ID: mdl-12669503

RESUMO

With the aim to assess the influence of pre-examination psychoemotional stress on the level of centralization of the heart rate control, mathematical analysis of ECG of students was performed in normal condition (a common day of academic semester), before, and after an examination. The ECG was recorded and processed with the help of IBM-486 PC. R-R cardiointevalograms were processed by the method of variational pulsometry after Baevsky. Common quantitative heart rate indices were studied. The level of anxiety of students was assessed by Spilberger, and subjective estimations of general condition, activity and mood were obtained from the respective questionnaire. Three types of heart rate reactions on the examination stress were revealed. The reactions depended on the individual typological characteristics and the state of autonomic nervous system.


Assuntos
Frequência Cardíaca/fisiologia , Estresse Psicológico/psicologia , Estudantes/psicologia , Sistema Nervoso Autônomo/fisiologia , Avaliação Educacional , Eletrocardiografia , Processamento Eletrônico de Dados , Humanos , Psicofisiologia/instrumentação
12.
Gig Sanit ; (3): 41-4, 2002.
Artigo em Russo | MEDLINE | ID: mdl-12198903

RESUMO

Current psychological tests and classic methods for recording and calculating autonomic correlates were used to study changes in students' psychophysiological indices during examinations. During this period, the students were found to develop emotional stress characterized by a complex of psychophysiological and autonomic changes. The nature and direction of the latter were determined by the individual and typological properties the examinees, by the significance of the emotional and stress situation of the autonomic nervous system and its responsiveness.


Assuntos
Sistema Nervoso Autônomo/fisiologia , Fenômenos Fisiológicos Cardiovasculares , Estudantes de Medicina/psicologia , Escala de Ansiedade Frente a Teste/estatística & dados numéricos , Adolescente , Adulto , Armênia , Educação de Graduação em Medicina/estatística & dados numéricos , Avaliação Educacional/estatística & dados numéricos , Feminino , Humanos , Masculino , Estresse Psicológico/etiologia
13.
Ter Arkh ; 74(2): 31-5, 2002.
Artigo em Russo | MEDLINE | ID: mdl-11899820

RESUMO

AIM: To examine validity of using interferon inductors (amixin and cycloferon) in combined treatment of patients with non-specific ulcerous colitis (NUC). MATERIAL AND METHODS: 113 NUC patients received basic antiinflammatory therapy (glucocorticoids and preparations of 5-aminosalycylic acid). Patients of groups 1 and 2 received interferon inductors (amixin and cycloferon in tables), respectively. Patients of groups 1a and 2a received placebo. All the patients were examined clinically with evaluation of interferon status and cellular immunity before and after the treatment. Colon mucosa biopsies obtained endoscopically were studied histologically. RESULTS: Alpha- and gamma-interferon production by leukocytes was substantially suppressed in all the examinees against normal levels of serum and spontaneous interferon. The interferon inductors stimulated relief of clinical symptoms and eliminated endoscopic signs of the disease. Amixin and cycloferon normalized interferon status in 36.3 and 33.3% of the treated patients, respectively. No response was registered in 9.1 and 8.4%, respectively. Improvement was seen in 54.6 and 58.3%, respectively. CONCLUSION: Cycloferon and amixin, interferon inductors, are effective in the treatment of NUC.


Assuntos
Acridinas/uso terapêutico , Colite Ulcerativa/tratamento farmacológico , Indutores de Interferon/uso terapêutico , Interferons/sangue , Tilorona/uso terapêutico , Acridinas/efeitos adversos , Adulto , Anti-Inflamatórios/uso terapêutico , Colite Ulcerativa/imunologia , Quimioterapia Combinada , Feminino , Humanos , Indutores de Interferon/efeitos adversos , Masculino , Placebos , Tilorona/efeitos adversos
14.
Klin Med (Mosk) ; 80(1): 15-9, 2002.
Artigo em Russo | MEDLINE | ID: mdl-11855309

RESUMO

Etiology of nonspecific ulcerous colitis (NSUC) as well as its pathogenetic mechanisms remain obscure. Cytokines are presently shown to play an essential role in development of inflammation. Cytokines are produced by the cells in the inflammatory infiltrate in NSUC, therefore, changes of their level in the blood and biopsies from colon mucosa is naturally determined. Current investigations register various changes in the levels of both proinflammatory and antiinflammatory cytokines. Further studies of unknown mechanisms of cytokines action may contribute to design of new methods of NSUC management.


Assuntos
Colite Ulcerativa/imunologia , Citocinas/fisiologia , Citocinas/imunologia , Humanos
15.
Artigo em Russo | MEDLINE | ID: mdl-12506629

RESUMO

The impact of purified staphylococcal toxoid (PST) on the in vitro production of interferon (IFN) by blood leukocytes was evaluated. PST was found to produce a stimulating effect on the production of alpha-IFN in patients with atopic dermatitis (AD): in 88% of cases a two-fivefold increase in IFN production was observed in AD patients in comparison with healthy donors. In addition, the incubation of leukocytes obtained from atopic and nonatopic patients with PST was shown to stimulate the production of gamma-IFN by these leukocytes fivefold, on the average. These results give theoretical basis for use of PST (as an inducer of endogenic IFN) for AD patients treatment.


Assuntos
Dermatite Atópica/imunologia , Interferon-alfa/biossíntese , Interferon gama/biossíntese , Leucócitos Mononucleares/imunologia , Toxoide Estafilocócico/farmacologia , Células Cultivadas , Dermatite Atópica/sangue , Humanos , Técnicas In Vitro , Interferon-alfa/efeitos dos fármacos , Interferon gama/efeitos dos fármacos , Masculino , Toxoide Estafilocócico/isolamento & purificação
16.
Vestn Otorinolaringol ; (5): 54-7, 2000.
Artigo em Russo | MEDLINE | ID: mdl-11051860

RESUMO

Seventy three patients aged 16 to 88 years who had laryngeal papillomatosis (LP) were followed up. Microsurgical endolaryngeal removal of laryngeal papillomas was made in all the patients. The interferon inducers amixine and cycloferon as antirecurrent drugs were used in 45 patients by the regime the authors developed by taking into account the interferon status and cellular immunity of patients. The criteria for the efficiency of treatment were their improved interferon status and longer remission. The efficiency of treatment with amixine and cycloferon was 72 and 80%, respectively. Thus, the use of a sparing microsurgical intervention in combination with interferon inducers may be regarded as the method of choice in the LP treatment.


Assuntos
Acridinas/uso terapêutico , Indutores de Interferon/uso terapêutico , Neoplasias Laríngeas/tratamento farmacológico , Papiloma/tratamento farmacológico , Tilorona/uso terapêutico , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Terapia Combinada , Feminino , Humanos , Neoplasias Laríngeas/diagnóstico , Neoplasias Laríngeas/cirurgia , Masculino , Microcirurgia , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Papiloma/diagnóstico , Papiloma/cirurgia
17.
Vopr Virusol ; 44(3): 130-3, 1999.
Artigo em Russo | MEDLINE | ID: mdl-10392438

RESUMO

Cycloferon, a low molecular weight interferon inducer synthesized in Russia, was used for treating chronic acute gynecological inflammations. The etiology of diseases was mixed in the majority of cases. Clinical efficacy of the drug was 79%. Cycloferon, an antiviral immunomodulating drug, is recommended for combined therapy of chronic and acute gynecological inflammations.


Assuntos
Acridinas/uso terapêutico , Doenças dos Genitais Femininos/tratamento farmacológico , Indutores de Interferon/uso terapêutico , Doença Aguda , Contagem de Linfócito CD4 , Relação CD4-CD8 , Linfócitos T CD8-Positivos , Doença Crônica , Feminino , Doenças dos Genitais Femininos/imunologia , Humanos , Inflamação/tratamento farmacológico , Inflamação/imunologia
19.
Aviakosm Ekolog Med ; 32(1): 77-9, 1998.
Artigo em Russo | MEDLINE | ID: mdl-9606520

RESUMO

High-molecular polymers apt to directly influence flow microstructure were tested as a fundamentally new method for correcting microhemodynamics in microgravity. Pressure in the mesenteric arterial microvessels was measured two weeks in rats adapted to the head-down suspension. Intravenous polyethylene oxide (Polyox WSR-301, end-concentration in the order of 2.10(-7) g/ml), reduced the microvascular pressure by 26%, whereas in the control pressure was reduced by only 15%. Systemic arterial pressure showed an equal drop in the groups (by 10 to 11%). These results suggest that the biomechanical agent weakens resistance to the blood flow in the body region where blood supply is impaired by microgravity.


Assuntos
Adaptação Psicológica , Hipotensão Ortostática , Artérias Mesentéricas/efeitos dos fármacos , Polietilenoglicóis/farmacologia , Polímeros/farmacologia , Animais , Hemodinâmica/efeitos dos fármacos , Ratos , Fatores de Tempo , Ausência de Peso
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