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1.
Natl Sci Rev ; 8(5): nwaa155, 2021 May.
Artigo em Inglês | MEDLINE | ID: mdl-34691632

RESUMO

The rapid, complete, targeted and safe treatment for tumors remains a key issue in cancer therapy. A novel treatment of solid tumors by supramolecular photocatalyst Nano-SA-TCPP with the irradiation of 600-700 nm wavelength is established. Solid tumors (100 mm3) can be eliminated within 10 min. The 50-day mouse survival rate was increased from 0% to 100% after the photocatalytic therapy. The breakthrough was owing to the cell membrane rupture and the cytoplasmic loss caused by photogenerated holes inside cancer cells. The porphyrin-based photocatalysts can be internalized in a targeted manner by cancer cells due to the size selection effect, without entering the normal cells. The therapy has no toxicity or side effects for normal cells and organisms. Moreover, the photocatalytic therapy is effective for a variety of cancer cell lines. Because of its high efficiency, safety and universality, the photocatalytic therapy provides us with a new lancet to conquer the tumor.

2.
Adv Healthc Mater ; 10(18): e2100539, 2021 09.
Artigo em Inglês | MEDLINE | ID: mdl-34319006

RESUMO

Nonapoptotic ferroptosis has been a novel form of programmed cell death, which provides a new solution to enrich the anticancer treatment efficacy of traditional apoptotic therapeutic modality. Herein, a novel nanohybrid is designed by loading the PEG-encapsulated Artemisinin (denoted as A@P) on the ultrathin MgFe-LDH nanosheets (denoted as uLDHs) for improved chemodynamic therapy (CDT). The A@P/uLDHs cannot only realize the self-assembly between the Art and carrier but also be regarded as free radical generator. A comprehensive mechanistic study suggests that this unique A@P/uLDHs is able to in situ activate Art and self-cycling generate toxic C-centered free radical inside the cancer cells, without depending on abundant H2 O2 , accompanied with diminished cancerous antioxidation by depleting glutathione (GSH). The accumulation of ROS and depletion of GSH can further oxidize unsaturated fatty acid to generate lipid peroxide, whose overexpression can induce cell ferroptosis accompanied by cellular iron homeostasis turbulence. Both in vitro and in vivo results exhibit that A@P/uLDHs are an efficient nanoagent for highly efficient ferroptosis-enhanced CDT treatment. This work imparts the promising new visions about the ferroptosis-enhanced CDT via fine regulation of material design for improved cancer treatments.


Assuntos
Ferroptose , Neoplasias , Linhagem Celular Tumoral , Radicais Livres , Glutationa/metabolismo , Humanos , Neoplasias/tratamento farmacológico , Oxirredução
3.
ACS Biomater Sci Eng ; 7(7): 3370-3378, 2021 07 12.
Artigo em Inglês | MEDLINE | ID: mdl-34120445

RESUMO

Recently, tremendous attention has been evoked in the discovery of defect-engineered nanomaterials for near-infrared second window (NIR-II)-driven cancer therapy. Herein, we have constructed a novel type of carbon defects enriched in boron carbide nanomaterial (denoted as B4C@C) through reacting B4C and glucose by a hydrothermal method. The carbon defect concentration in B4C@C has been significantly increased after coating with glucose; thus, B4C@C exhibited a distinct photothermal response under the NIR-II window and the efficiency of photothermal conversion is determined to reach 45.4%, which is higher than the carbon-based nanomaterials in the NIR-II region. Both Raman spectra and X-ray photoelectron spectroscopy (XPS) spectra reveal that B4C@C has rich sp2-hybridized carbon defects and effectively increases the NIR-II window light absorption capacity, thus enhancing the nonradiative recombination rate and improving the NIR-II photothermal effect. Furthermore, the B4C@C nanosheets allows for tumor phototherapy and simultaneous photoacoustic imaging. This work indicates the huge potential of B4C@C as a novel photothermal agent, which might arise much attention in exploring boron-based nanomaterials for the advantage of cancer therapy.


Assuntos
Técnicas Fotoacústicas , Boro , Carbono , Fototerapia , Terapia Fototérmica
4.
ACS Appl Mater Interfaces ; 13(15): 17920-17930, 2021 Apr 21.
Artigo em Inglês | MEDLINE | ID: mdl-33827214

RESUMO

For the design and optimization of near-infrared photothermal nanohybrids, tailoring the energy gap of nanohybrids plays a crucial role in attaining a satisfactory photothermal therapeutic efficacy for cancer and remains a challenge. Herein, we report an electron donor-acceptor effect-induced organic/inorganic nanohybrid with a low energy gap (denoted as ICG/Ag/LDH) by the in situ deposition of Ag nanoparticles onto the CoAl-LDH surface, followed by the coupling of ICG. A combination study verifies that the supported Ag nanoparticles as the electron donor (D) push electrons into the conjugated system of ICG by the electronic interaction between ICG and Ag, while OH groups of LDHs as the electron acceptor (A) pull electrons from the conjugated system of ICG by hydrogen bonding (N···H-O). This induces the formation of the D-A conjugated π-system and has a strong influence on the π-conjugated system of ICG, thus leading to a prominent decrease toward the energy gap and correspondingly an ultra-long redshift (∼115 nm). The resulting ICG/Ag/LDHs show an enhanced photothermal conversion efficiency (∼45.5%) at 808 nm laser exposure, which is ∼1.6 times larger than that of ICG (∼28.4%). Such a high photothermal performance is attributed to the fact that ICG/Ag/LDHs possess a D-π-A hybrid structure and a resulting lower energy gap, thus effectively promoting nonradiative transitions and leading to enhancement of the photothermal effect. Both in vitro and in vivo results confirm the good biocompatible properties and capability of the ICG/Ag/LDHs for NIR-triggered cancer treatment. This research demonstrates a successful paradigm for the rational design and preparation of new nanohybrids through the modulation of electron donor-acceptor effect, which offers a new avenue to achieve efficient phototherapeutic agent for improving the cancer therapeutic outcomes.


Assuntos
Nanopartículas Metálicas/química , Nanocompostos/química , Nanocompostos/uso terapêutico , Nanomedicina/métodos , Compostos Orgânicos/química , Fototerapia/métodos , Prata/química , Transporte de Elétrons , Ligação de Hidrogênio , Propriedades de Superfície
5.
ACS Appl Mater Interfaces ; 12(49): 54916-54926, 2020 Dec 09.
Artigo em Inglês | MEDLINE | ID: mdl-33233881

RESUMO

Currently, two-dimensional materials are being actively pursued in catalysis and other fields due their abundance of defects, which results in enhanced performance relative to their bulk defect-free counterparts. To date, the exploitation of defects in two-dimensional materials to enhance photothermal therapies has received little attention, motivating a detailed investigation. Herein, we successfully fabricated a series of novel CoFe-based photothermal agents (CoFe-x) by heating CoFe-layered double hydroxide (CoFe-LDH) nanosheets at different temperatures (x) between 200-800 °C under a Ar atmosphere. The CoFe-x products differed in their particle size, cobalt defect concentration, and electronic structure, with the CoFe-500 product containing the highest concentration of Co2+ defects and most efficient photothermal performance under near-infrared (NIR, 808 nm) irradiation. Experiments and density functional theory (DFT) calculations revealed that Co2+ defects modify the electronic structure of CoFe-x, narrowing the band gap and thus increasing the nonradiative recombination rate, thereby improving the NIR-driven photothermal properties. In vitro and in vivo results demonstrated that CoFe-500 was an efficient agent for photothermal cancer treatment and also near-infrared (NIR) thermal imaging, magnetic resonance (MR) imaging, and photoacoustic (PA) imaging. This work provides valuable new insights about the role of defects in the rational design of nanoagents with optimized structures for improved cancer therapy.


Assuntos
Cobalto/química , Compostos Férricos/química , Hidróxidos/química , Nanoestruturas/química , Neoplasias/terapia , Animais , Sobrevivência Celular/efeitos dos fármacos , Teoria da Densidade Funcional , Células HeLa , Humanos , Raios Infravermelhos , Camundongos , Camundongos Nus , Nanoestruturas/uso terapêutico , Nanoestruturas/toxicidade , Neoplasias/diagnóstico por imagem , Neoplasias/patologia , Tamanho da Partícula , Técnicas Fotoacústicas , Terapia Fototérmica
6.
J Mater Chem B ; 8(43): 9881-9887, 2020 11 11.
Artigo em Inglês | MEDLINE | ID: mdl-33001121

RESUMO

Quantum dots (QDs) are increasingly being utilized as near infrared (NIR) active photothermal agents for cancer diagnosis and therapy, with the main emphasis of current research being the enhancement of photothermal conversion efficiencies. Herein, we report the facile synthesis of 2-3 nm boron quantum dots (B QDs), which demonstrated a remarkable photothermal conversion efficiency of 57% under NIR excitation. This outstanding performance can be attributed to the alteration of the electronic structure, which was a result from the distorted edge-effect induced by the unique empty orbit of B atoms in the B QDs. These results can be verified by B K-edge near edge X-ray absorption fine structure (NEXAFS), high-resolution transmission electron microscopy (HR-TEM) and density functional theory (DFT) calculations. The results demonstrate that B QDs represent a promising new and non-toxic agent for both multimodal NIR-driven cancer imaging and photothermal therapy. This work thus identifies B QDs as an exciting new and theranostic agent for cancer therapy. Furthermore, the synthetic strategy used here to synthesize the B QDs was simple and easily scalable.


Assuntos
Boro/uso terapêutico , Neoplasias/terapia , Terapia Fototérmica , Pontos Quânticos/uso terapêutico , Boro/química , Células HeLa , Humanos , Modelos Moleculares , Neoplasias/diagnóstico , Técnicas Fotoacústicas , Pontos Quânticos/química , Nanomedicina Teranóstica
7.
Bioresour Technol ; 302: 122878, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32014318

RESUMO

In order to improve the yield of reducing sugar from corn stalk, ultrasonic-assisted ammonium bicarbonate pretreatment of corn stalk was proposed. Three ultrasonic factors (time (0-30 min), temperature (30-60 °C) and liquid/solid mass ratio (5-20)) were optimized by response surface experiment. The optimal conditions of ultrasonic pretreatment were obtained (liquid/solid mass ratio is 12:1, temperature is 42 °C and time is 11 min). The highest saccharification rate of corn stalk was of 82.61%, which was remarkably increased by 355% compared to the control group.


Assuntos
Açúcares , Zea mays , Bicarbonatos , Carboidratos , Hidrólise , Ultrassom
8.
Small ; 16(1): e1905184, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-31788959

RESUMO

Currently, there is tremendous interest in the discovery of new and improved photothermal agents for near-infrared (NIR)-driven cancer therapy. Herein, a series of novel photothermal agents, comprising copper nanoparticles supported on defective porous carbon polyhedra are successfully prepared by heating a Cu-BTC metal-organic framework (MOF) precursor at different temperatures (t) in the range 400-900 °C under an argon atmosphere. The copper nanoparticle size and carbon defect concentration in the obtained products (denoted herein as Cu@CPP-t) increase with synthesis temperature, thus imparting the Cu@CPP-t samples with distinct NIR absorption properties and photothermal heating responses. The Cu@CPP-800 sample shows a remarkable photothermal conversion efficiency of 48.5% under 808 nm laser irradiation, representing one of the highest photothermal efficiencies yet reported for a carbon-based photothermal agent. In vivo experiments conducted with tumor bearing nude Balb/c mice confirm the efficacy of Cu@CPP-800 as a very promising NIR-driven phototherapy agent for cancer treatment. Results encourage the wider use of MOFs as low cost precursors for the synthesis of carbon-supported metal nanoparticle composites for photothermal therapy.


Assuntos
Carbono/química , Cobre/química , Raios Infravermelhos , Nanopartículas Metálicas/química , Neoplasias/terapia , Fototerapia , Porosidade , Linhagem Celular Tumoral , Humanos , Estruturas Metalorgânicas/química , Difração de Raios X
9.
ACS Appl Mater Interfaces ; 11(38): 35228-35237, 2019 Sep 25.
Artigo em Inglês | MEDLINE | ID: mdl-31479230

RESUMO

In recent years, single-atom catalysts (SACs) have attracted enormous attention due their effectiveness in promoting a variety of catalytic reactions. However, the ability of SACs to enhance cancer phototherapies has received little attention to date. Herein, we synthesized a metal organic framework (MOF) rich in porphyrin-like single atom Fe(III) centers (denoted herein as porphyrin-MOF or P-MOF) and then evaluated the performance of the P-MOF for cancer treatment by photodynamic therapy (PDT) and photothermal therapy (PTT) under NIR (808 nm) irradiation, as well as photoacoustic imaging (PAI) of tumors. On acccount of the abundance of single atom Fe(III) centers, the P-MOF material demonstrated excellent performance for modulation of the hypoxic tumor microenvironment of Hela cell tumors in mice, while also demonstrating good properties as a photoacoustic imaging (PAI) agent. Density functional theory (DFT) calculations were used to elucidate the superior performance of P-MOF in these applications relative to Fe2O3 (a Fe(III) reference compound). The calculations revealed that the narrow band gap energy of P-MOF (1.31 eV) enabled strong absorption of NIR photons, thereby inducing nonradiative transitions that converted incident light into heat to promote PTT. Further, a facile change of the spin state of the single atom Fe(III) centers in P-MOF under NIR irradiation transformed coordinated triplet oxygen (3O2) to singlet oxygen (1O2), benefiting PDT. This work demonstrates the great future potential of both SACs and MOFs as multifunctional agents for cancer treatment and tumor imaging.


Assuntos
Estruturas Metalorgânicas , Modelos Químicos , Neoplasias/tratamento farmacológico , Fotoquimioterapia , Porfirinas , Microambiente Tumoral/efeitos dos fármacos , Células HeLa , Humanos , Estruturas Metalorgânicas/química , Estruturas Metalorgânicas/farmacologia , Neoplasias/metabolismo , Neoplasias/patologia , Porfirinas/química , Porfirinas/farmacologia
10.
Bioresour Technol ; 292: 122052, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31473038

RESUMO

This work studied the effects of ammonium carbonate pretreatment on biogas production during sequential anaerobic digestion. The results showed that the addition of ammonium bicarbonate (8%, w/w) obtained the highest biogas production of 14,690 mL with a yield of 222.6 mL g-1, which was 31% higher than that of un-pretreated (control experiment). Interestingly, the COD removal was increased by 100%. Furthermore, it was also helpful in stabilizing the pH of anaerobically digested corn stalk. Based on the results, the modified Gompertz equation fitted the cumulative biogas production curves very well, with high correlation coefficients (>0.994).


Assuntos
Metano , Zea mays , Anaerobiose , Bicarbonatos , Biocombustíveis
11.
Chem Sci ; 10(8): 2336-2341, 2019 Feb 28.
Artigo em Inglês | MEDLINE | ID: mdl-30881661

RESUMO

Oxygen vacancy (OV) engineering in semiconductors can greatly enhance the separation of photo-induced electron-hole pairs, thereby enhancing the photocatalytic activity. Taking inspiration from this, we prepared a novel BiOBr-H/Rub2d composite by functionalizing OV-rich BiOBr (named BiOBr-H) with a carboxyl functionalized ruthenium photosensitizer (Ru(bpy)2C-pyCl2, abbreviated as Rub2d), which was then successfully applied for photodynamic therapy (PDT). Density functional theory (DFT) calculations confirmed efficient electron transfer from the Rub2d complex to the intermediate energy level of BiOBr-H under visible light irradiation. In vitro and in vivo studies demonstrated that BiOBr-H/Rub2d was a superior agent for photodynamic therapy compared with the free ruthenium complex. The theoretical and experimental data presented thus reveal for the first time that abundant OVs in BiOBr-H can significantly improve the photocatalytic activity of a photosensitizer, resulting in the generation of more reactive oxygen species to enhance PDT. The findings of this study thus offer a new strategy for the development of highly efficient cancer therapies.

12.
ACS Appl Mater Interfaces ; 11(6): 6267-6275, 2019 Feb 13.
Artigo em Inglês | MEDLINE | ID: mdl-30672683

RESUMO

In medical applications, two-dimensional nanomaterials have been widely studied on account of their intriguing properties such as good biocompatibility, stability, and multifunctionality. Herein, an ultrathin MnO2 nanosheet has been fabricated by a simplistic hydrothermal process. The high photothermal conversion performance (62.4%) can be attributed to the vacancy in the ultrathin MnO2 nanosheet, as confirmed by the extended X-ray absorption fine structure results and the density functional theory calculation, benefiting photoacoustic imaging-guided cancer therapy. This highly efficient vacancy-induced photothermal therapy has been reported for the first time. As a result, this work demonstrates that this ultrathin MnO2 nanosheet has a potential to construct a nanosystem for imaging-guided cancer therapy.


Assuntos
Compostos de Manganês/química , Nanoestruturas/química , Óxidos/química , Animais , Sobrevivência Celular/efeitos dos fármacos , Células HeLa , Humanos , Peróxido de Hidrogênio/química , Raios Infravermelhos , Compostos de Manganês/uso terapêutico , Camundongos , Nanoestruturas/toxicidade , Neoplasias/tratamento farmacológico , Neoplasias/patologia , Neoplasias/terapia , Óxidos/uso terapêutico , Fototerapia , Transplante Heterólogo
13.
J Mater Chem B ; 7(11): 1920-1925, 2019 03 21.
Artigo em Inglês | MEDLINE | ID: mdl-32255054

RESUMO

Okara is a by-product of tofu manufacturing and is usually used as a feedstuff. Herein, we developed a methodology of using okara as a carbon source for the preparation of photothermal nano-materials. It's interesting to find that just after calcination, the carbonized okara forms sphere-shaped hollow particles (denoted as HCNS) with an average diameter of 200 nm. Owning to the existence of a cavity, the HCNS was found to exhibit not only a good photothermal conversion efficiency, but also an ideal photoacoustic imaging property, which makes it a promising agent for imaging-guided photothermal therapy (PTT). The high photothermal conversion efficiency can result from the high carbon content and its hollow morphology. The in vitro and in vivo results both demonstrated the biocompatibility and capacity of the plant source carbon spheres for NIR-triggered cancer treatment. Therefore, the current work suggests a new method to gain a safe and low-cost photothermal platform which could be further exploited in biomedical fields.


Assuntos
Carbono/química , Nanosferas/uso terapêutico , Neoplasias/terapia , Fototerapia/métodos , Nanomedicina Teranóstica/métodos , Animais , Materiais Biocompatíveis/uso terapêutico , Células HeLa , Células Hep G2 , Humanos , Hipertermia Induzida , Células MCF-7 , Masculino , Camundongos Endogâmicos BALB C , Camundongos Nus , Proteínas de Plantas/química , Polissacarídeos/química , Alimentos de Soja
14.
Ultrasonics ; 91: 161-169, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30146324

RESUMO

Resistance spot welding (RSW) ultrasonic testing signal contains nugget size and internal defect information which can reflect the mechanical property of spot-welded joint. The mechanical property of spot-welded joint is the most direct indicator for evaluation of spot welding quality. In this paper, 100 samples of different quality spot-welded joints are detected by ultrasonic detection technology, then ultrasonic signals are processed by fast Fourier transform (FFT) and wavelet packet transform (WPT). After that, mathematical statistical methods are used to feature extraction for ultrasonic detection signals in time domain, frequency domain, and wavelet domain based on WPT. 100 samples are subjected to tensile-shear tests to obtain the maximum tensile-shear strength (MTSS) that is used as the classification identifier here. Finally, back-propagation (BP) neural network classifier and particle swarm optimization support vector machine (PSO-SVM) classifier are used to classify the MTSS of spot-welded joints and comparing the accuracy of the two classifiers with different number of features. The results show that the PSO-SVM classifier with all 9 features has a good accuracy, which verifies the feasibility and correctness of the spot welding quality classification method proposed in this paper.


Assuntos
Resistência à Tração , Ultrassom , Soldagem , Algoritmos , Análise de Fourier , Máquina de Vetores de Suporte , Análise de Ondaletas
15.
Nanomaterials (Basel) ; 8(9)2018 Sep 10.
Artigo em Inglês | MEDLINE | ID: mdl-30201913

RESUMO

Emphasis using phototheranostics has been placed on the construction of multifunctional nanoplatforms for simultaneous tumor diagnosis and therapy. Herein, we put forth a novel nanosized luminescent material using the incorporation of red emissive carbon dots on gold nanorods through polyethylene glycol as a covalent linkage for dual-modal imaging and photothermal therapy. The novel nanohybrids, not only retain the optical properties of the gold nanorod and carbon dots, but also possess superior imaging performance in both confocal laser scanning microscopy and fluorescence lifetime imaging microscopy. The nanohybrids also exhibit excellent photothermal performance as phototheranostic nanohybrid probes for in vitro assays. This study promises a new multifunctional nanoplatform for cancer diagnostics and therapeutics.

16.
Carbohydr Polym ; 197: 38-46, 2018 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-30007626

RESUMO

To increase pancreatic tumor-targeted phototoxicity of photosensitizers, a hyperbranched cationic amylopectin derivative conjugated with 3-(dimethylamino)-1-propylamine (DMAPA-Amp) was invevstigated as a multi-guest molecular host for the targeted delivery of a photosensitizer to human pancreatic cancer (Panc-1) cells. We selected protoporphyrin IX (PpIX) and folic acid as a photosensitizer and a tumor-targeting factor, respectively. The complexation mechanism of DMAPA-Amp with PpIX and folic acid was characterized using NMR spectroscopy including 1H NMR, two-dimensional diffusion ordered spectroscopy (2D DOSY) NMR, fluorescence and UV-vis spectroscopy. The results indicated that the DMAPA-Amp derivative could serve as a host for the encapsulation of two guests, PpIX and folic acid, through intermolecular interactions. The complex showed high phototoxicity against Panc-1 cells, and its folic-acid-mediated cancer-cell-targeting property was confirmed by laser confocal microscopy and flow cytometry analysis. We provide a method to study hyperbranched cationic polymer-based complexes containing multiple guests, which could facilitate the design of multi-functional complexes in the drug delivery field.


Assuntos
Amilopectina/química , Sistemas de Liberação de Medicamentos , Ácido Fólico/farmacologia , Neoplasias Pancreáticas/tratamento farmacológico , Fármacos Fotossensibilizantes/farmacologia , Protoporfirinas/farmacologia , Cátions/química , Linhagem Celular Tumoral , Sobrevivência Celular/efeitos dos fármacos , Relação Dose-Resposta a Droga , Ácido Fólico/química , Humanos , Espectroscopia de Ressonância Magnética , Neoplasias Pancreáticas/patologia , Fármacos Fotossensibilizantes/química , Protoporfirinas/química , Espectrometria de Fluorescência , Espectrometria por Raios X , Espectrofotometria Ultravioleta , Relação Estrutura-Atividade
17.
ACS Appl Mater Interfaces ; 10(18): 16005-16014, 2018 May 09.
Artigo em Inglês | MEDLINE | ID: mdl-29663793

RESUMO

Carbon dots (CDs) have potentials to be utilized in optoelectronic devices, bioimaging, and photocatalysis. The majority of the current CDs with high quantum yield to date were limited in the blue light emission region. Herein, on the basis of surface electron-state engineering, we report a kind of CDs with reversible switching ability between green and red photoluminescence with a quantum yield (QY) of both up to 80%. Highly efficient green and red solid-state luminescence is realized by doping CDs into a highly transparent matrix of methyltriethoxysilane and 3-triethoxysilylpropylamine to form CDs/gel glasses composites with QYs of 80 and 78%. The CDs/gel glasses show better transmittance in visible light bands and excellent thermal stability. A blue-pumped CDs/gel glasses phosphor-based trichromatic white light-emitting diode (WLED) is realized, whose color rendering index is 92.9. The WLED gets the highest luminous efficiency of 71.75 lm W-1 in CDs-based trichromatic WLEDs. This work opens a door for developing highly efficient green- and red-emissive switching CDs which were used as phosphors for WLEDs and have the tendency for applications in other fields, such as sensing, bioimaging, and photocatalysis.

18.
Talanta ; 184: 50-57, 2018 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-29674075

RESUMO

It is a great challenge to develop multifunctional nanocarriers for cancer diagnosis and therapy. Herein, versatile CDs/ICG-uLDHs nanovehicles for triple-modal fluorescence/photoacoustic/two-photon bioimaging and effective photothermal therapy were prepared via a facile self-assembly of red emission carbon dots (CDs), indocyanine green (ICG) with the ultrathin layered double hydroxides (uLDHs). Due to the J-aggregates of ICG constructed in the self-assembly process, CDs/ICG-uLDHs was able to stabilize the photothermal agent ICG and enhanced its photothermal efficiency. Furthermore, the unique confinement effect of uLDHs has extended the fluorescence lifetime of CDs in favor of bioimaging. Considering the excellent in vitro and in vivo phototherapeutics and multimodal imaging effects, this work provides a promising platform for the construction of multifunctional theranostic nanocarrier system for the cancer treatment.


Assuntos
Carbono/química , Corantes Fluorescentes/química , Hidróxidos/química , Neoplasias/diagnóstico por imagem , Imagem Óptica , Fototerapia , Pontos Quânticos/química , Fluorescência , Humanos , Hidróxidos/síntese química , Neoplasias/terapia
19.
Adv Healthc Mater ; 7(10): e1701123, 2018 05.
Artigo em Inglês | MEDLINE | ID: mdl-29430871

RESUMO

In this work, a novel ruthenium complex loaded monolayer layered double hydroxide (LDH) (denoted as Ru(C-bpy)2 /mLDH) as supramolecular nanosensor is synthesized, which is greatly exclusive to the hypoxic tumor microenvironment. The Ru(C-bpy)2 /mLDH ultrathin sheet displays not only enhanced luminescence lifetime compared to the parent Ru(C-bpy)2 alone, but also improved oxygen responsibility under an excitation of 488 or 800 nm. Moreover, the Ru(C-bpy)2 /mLDH is possessed of two-photon fluorescence imaging ability under the 800 nm irradiation. In addition, the Ru(C-bpy)2 /mLDH can generate singlet oxygen with a high yield (φ∆ ) of 0.28 under the 520 nm irradiation, while the φ∆ of Ru(C-bpy)2 is 0.19. Therefore, the Ru(C-bpy)2 /mLDH can be applied as a supramolecular theranostic agent with light-switchable cancer imaging and photodynamic therapy properties.


Assuntos
Nanoestruturas , Neoplasias Experimentais , Fotoquimioterapia , Compostos de Rutênio , Nanomedicina Teranóstica , Hipóxia Tumoral , Microambiente Tumoral , Animais , Diagnóstico por Imagem , Células HeLa , Humanos , Medições Luminescentes , Camundongos , Camundongos Nus , Nanoestruturas/química , Nanoestruturas/uso terapêutico , Neoplasias Experimentais/tratamento farmacológico , Neoplasias Experimentais/metabolismo , Neoplasias Experimentais/patologia , Compostos de Rutênio/síntese química , Compostos de Rutênio/química , Compostos de Rutênio/farmacologia , Nanomedicina Teranóstica/métodos , Ensaios Antitumorais Modelo de Xenoenxerto
20.
J Mater Chem B ; 6(15): 2315-2322, 2018 Apr 21.
Artigo em Inglês | MEDLINE | ID: mdl-32254570

RESUMO

In this work, we synthesized a hypoxia responsive upconversion nanosensor by the conjugation of oxygen insensitive upconversion carbon dots (CDs) with an oxygen sensitive ruthenium(ii) complex (Rud2b). The CD-Rud2b conjugate was then PEGylated to mediate the formation of nano-sized assemblies of the resultant polymer probe (CD-Ru-mPEG) in aqueous solution. The strategy allows the oxygen sensitive probe (Rud2b) to be excited by NIR irradiation and achieve upconverted emission through the Förster resonance energy transfer process from the CDs. The oxygen sensitivity of the ruthenium moiety was well-preserved in the polymeric aggregates because the PEG chains could prohibit the occurrence of self-quenching that may occur due to the close packing of the probes. Such an upconversion photoluminescence property makes the CD-Ru-mPEG nanosensor work as a biocompatible imaging system to monitor the oxygen level in cells and the hypoxic condition in vivo.

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