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1.
Expert Rev Clin Pharmacol ; 10(11): 1203-1214, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-28836870

RESUMO

INTRODUCTION: In the modern antimicrobial era, the rapid spread of resistance to antibiotics and introduction of new and mutating viruses is a global concern. Combating antimicrobial resistant microbes (AMR) requires coordinated international efforts that incorporate new conventional antibiotic development as well as development of alternative drugs with antimicrobial activity, management of existing antimicrobials, and rapid detection of AMR pathogens. Areas covered: This manuscript discusses some conventional strategies to control microbial resistance. The main purpose of the manuscript is to present information on specific herbal medicines that may serve as good treatment alternatives to conventional antimicrobials for infections sensitive to conventional as well as resistant strains of microorganisms. Expert commentary: Identification of potential new antimicrobials is challenging; however, one source for potential structurally diverse and complex antimicrobials are natural products. Natural products may have advantages over other post-germ theory antimicrobials. Many antimicrobial herbal medicines possess simultaneous antibacterial, antifungal, antiprotozoal and/or antiviral properties. Herbal products have the potential to boost host resistance to infections, particularly in immunocompromised patients. Antimicrobial broad-spectrum activity in conjunction with immunostimulatory properties may help to prevent microbial resistance to herbal medicine. As part of the efforts to broaden use of herbal medicines to treat microbial infections, pre-clinical and clinical testing guidelines of these compounds as a whole should be implemented to ensure consistency in formulation, efficacy and safety.


Assuntos
Anti-Infecciosos/administração & dosagem , Fitoterapia/métodos , Preparações de Plantas/administração & dosagem , Animais , Anti-Infecciosos/farmacologia , Desenho de Fármacos , Resistência Microbiana a Medicamentos , Humanos , Hospedeiro Imunocomprometido , Infecções/tratamento farmacológico , Infecções/microbiologia , Preparações de Plantas/farmacologia
2.
Expert Rev Clin Pharmacol ; 10(3): 327-338, 2017 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-27923318

RESUMO

INTRODUCTION: Herbal medicine (HM) use is growing worldwide. Single herb preparations, ethnic and modern HM formulations are widely used as adjunct therapies or to improve consumer wellbeing. Areas covered: This final part in the publication series summarizes common tendencies in HM use as adjunct or alternative medicine, education of healthcare professionals and consumers, current and proposed guidelines regulating of production. We discuss potential HM-HM and HM-drug interactions that could lead to severe adverse events in situations where HMs are taken without proper medical professional oversight. Expert commentary: A number of serious problems have arisen with the steady global increase in HM use. HM interaction with conventional drugs (CD) may result in inadequate dosing of CD or adverse reactions; HM-HM interaction within herbal supplements could lead to toxicity of formulations. Inadequate education of clinicians and patients regarding medicinal properties of HMs must be addressed regionally and globally to ensure consumer safety.


Assuntos
Terapias Complementares/métodos , Fitoterapia/métodos , Preparações de Plantas/uso terapêutico , Animais , Terapias Complementares/efeitos adversos , Terapias Complementares/tendências , Interações Ervas-Drogas , Humanos , Fitoterapia/efeitos adversos , Fitoterapia/tendências , Preparações de Plantas/efeitos adversos , Plantas Medicinais/química
3.
Expert Rev Clin Pharmacol ; 9(8): 1117-27, 2016 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-27171366

RESUMO

INTRODUCTION: Herbal medicines (HMs) have been well known to people of the European Union (EU) and Russia for centuries. Currently, Western HMs can be classified into two categories, plant-derived conventional medicines and dietary supplements. Interest to HMs has grown rapidly in all countries during the past two decades. AREAS COVERED: The main goal of this review article is to present the history of HMs in the EU and Russia, forms of modern HMs, including Oriental Medicines that are popular among consumers of both countries. Additional discussion points comprise safety and adulteration issues associated with HMs, including regulatory changes and new legislative measures undertaken by the authorities. Materials available from legislative and governmental websites, PubMed and news media were used. Expert commentary: Due to cultural diversities in the EU and Russia, traditional HMs of other regions, particularly Chinese Traditional and Ayurvedic medicines, are also popular. Recently, dietary supplements containing multiple herbal and other natural products have flooded the EU and Russian markets. Pharmacovigilance in these markets is challenging in terms of establishing quality and safety of ingredients, determining efficacy, and defining risks of herb-herb and herb-drug interactions. Both the EU and Russia have introduced new legislation aimed to overcome these deficiencies.


Assuntos
Fitoterapia/métodos , Preparações de Plantas/uso terapêutico , Plantas Medicinais/química , Animais , Suplementos Nutricionais/efeitos adversos , Suplementos Nutricionais/normas , União Europeia , Interações Ervas-Drogas , Humanos , Legislação de Medicamentos , Medicina Tradicional/métodos , Preparações de Plantas/efeitos adversos , Preparações de Plantas/normas , Federação Russa
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