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1.
Vet Comp Orthop Traumatol ; 32(1): 33-40, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30485878

RESUMO

OBJECTIVE: The main purpose of this study was to define criteria to systemically describe craniovertebral junction (CVJ) anomalies and to report the prevalence of CVJ anomalies in small breed dogs with and without atlantoaxial instability (AAI). MATERIALS AND METHODS: Retrospective multicentre matched case-control study evaluating magnetic resonance imaging and computed tomographic images of small breed dogs with and without AAI for the presence of CVJ anomalies. RESULTS: One hundred and twenty-two dogs were enrolled (61 with and 61 without AAI). Only dogs with AAI had dens axis anomalies such as separation (n = 20) or a short-rounded conformation (n = 35). Patients with AAI were more likely to have atlantooccipital overlapping based on transection of McRae's line by the dorsal arch of the atlas (odds ratio [OR] = 5.62, p < 0.01), a transection of Wackenheim's clivus line (OR = 41.62, p < 0.01) and rostral indentation of the occipital bone (OR = 2.79, p < 0.05). Patients with AAI were less likely to have a larger clivus canal angle (OR = 0.94, p < 0.01) and larger occipital bone lengths (OR = 0.89, p < 0.05). CLINICAL SIGNIFICANCE: Small breed dogs with AAI are more likely to have other CVJ anomalies such as atlantooccipital overlapping or dens anomalies. The grade of brachycephaly does not differ between patients with and without AAI. Certain objective criteria from human literature were found useful for the assessment of both AAI and atlantooccipital overlapping such as McRae's line, Wackenheim's clivus line, and clivus canal angle. The classification criteria used can help to evaluate CVJ anomalies in a more systematic way.


Assuntos
Articulação Atlantoaxial/anormalidades , Articulação Atlantoccipital/anormalidades , Cães/anormalidades , Instabilidade Articular/veterinária , Animais , Articulação Atlantoaxial/diagnóstico por imagem , Articulação Atlantoccipital/diagnóstico por imagem , Estudos de Casos e Controles , Feminino , Instabilidade Articular/diagnóstico por imagem , Instabilidade Articular/etiologia , Imagem por Ressonância Magnética/veterinária , Masculino , Estudos Retrospectivos , Especificidade da Espécie , Tomografia Computadorizada por Raios X/veterinária
2.
Ecol Evol ; 8(22): 10868-10878, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30519413

RESUMO

Global ecosystem models are essential tools for predicting climate change impacts on marine systems. Modeled biogenic carbon fluxes in the ocean often match measured data poorly and part of this could be because small copepods (<2 mm) are modeled as unicellular feeders grazing on phytoplankton and microzooplankton. The most abundant copepods from a seasonal upwelling region of the Eastern North Atlantic were sorted, and a molecular method was applied to copepod gut contents to evaluate the extent of metazoan predation under two oceanographic conditions, a trophic pathway not accounted for in global models. Scaling up the results obtained herein, based on published field and laboratory estimates, suggests that small copepods could ingest 1.79-27.20 gigatons C/year globally. This ignored metazoan-copepod link could increase current estimates of biogeochemical fluxes (remineralization, respiration, and the biological pump) and export to higher trophic levels by 15.6%-24.4%. It could also account for global discrepancies between measured daily ingestion and copepod metabolic demand/growth. The inclusion of metazoan predation into global models could provide a more realistic role of the copepods in the ocean and if these preliminary data hold true at larger sample sizes and scales, the implications would be substantial at the global scale.

6.
Prog. obstet. ginecol. (Ed. impr.) ; 57(9): 413-417, nov. 2014.
Artigo em Espanhol | IBECS | ID: ibc-127147

RESUMO

El síndrome de insensibilidad a los andrógenos se caracteriza por la presencia de fenotipo femenino, gónadas masculinas y cariotipo 46,XY. Es la causa más común de seudohermafroditismo masculino y la tercera causa más frecuente de amenorrea primaria, después de la disgenesia gonadal y la ausencia congénita de vagina. Es una entidad cuya importancia radica en su diagnóstico precoz en la pubertad por el riesgo de desarrollo de tumoraciones testiculares. En este artículo se presenta un caso de diagnóstico tardío de síndrome de insensibilidad a los andrógenos asociado a adenoma de células de Sertoli (AU)


Androgen insensitivity syndrome is characterized by the presence of a female phenotype, masculine gonads, and 46,XY karyotype. This syndrome is the most common cause of masculine pseudohermaphroditism and is the third most frequent cause of primary amenorrhea after gonadal dysgenesis and congenital absence of the vagina. The importance of this entity lies in its early diagnosis in puberty because of the risk of testicular tumors. In this article, we present a case of late diagnosis of androgen insensitivity syndrome related to Sertoli cell adenoma (AU)


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Tumor de Células de Sertoli/complicações , Tumor de Células de Sertoli/diagnóstico , Tumor de Células de Sertoli/cirurgia , Diagnóstico Precoce , Síndrome de Resistência a Andrógenos/complicações , Síndrome de Resistência a Andrógenos/diagnóstico , Tumor de Células de Sertoli/fisiopatologia , Tumor de Células de Sertoli , Síndrome de Células de Sertoli/complicações , Síndrome de Células de Sertoli , Síndrome de Resistência a Andrógenos , Imagem por Ressonância Magnética/métodos , Imagem por Ressonância Magnética
7.
J Comp Psychol ; 128(4): 427-30, 2014 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-25198542

RESUMO

The first description of cannibalism in wild adult Octopus vulgaris is presented from 3 observations made in the Ría de Vigo (NW Spain), which were filmed by scuba divers. These records document common traits in cannibalistic behavior: (a) it was intercohort cannibalism; (b) attacks were made by both males and females; (c) in 2 of the records, the prey were transported to the den, which was covered with stones of different sizes; (d) the predator started to eat the tip of the arms of its prey; (e) predation on conspecifics occurred even if there were other abundant prey available (i.e., mussels); and (f) the prey/predator weight ratio in the 3 cases ranged from 20% to 25% body weight. The relationships between this behavior and sex, defense of territory, energy balance, food shortage, competition and predation, as well as how the attacker kills its victim are discussed.


Assuntos
Canibalismo , Octopodiformes/fisiologia , Comportamento Predatório/fisiologia , Animais , Feminino , Masculino , Fatores Sexuais
8.
Adv Mar Biol ; 67: 361-437, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24880797

RESUMO

Cephalopod life cycles generally share a set of stages that take place in different habitats and are adapted to specific, though variable, environmental conditions. Throughout the lifespan, individuals undertake a series of brief transitions from one stage to the next. Four transitions were identified: fertilisation of eggs to their release from the female (1), from eggs to paralarvae (2), from paralarvae to subadults (3) and from subadults to adults (4). An analysis of each transition identified that the changes can be radical (i.e. involving a range of morphological, physiological and behavioural phenomena and shifts in habitats) and critical (i.e. depending on environmental conditions essential for cohort survival). This analysis underlines that transitions from eggs to paralarvae (2) and from paralarvae to subadults (3) present major risk of mortality, while changes in the other transitions can have evolutionary significance. This synthesis suggests that more accurate evaluation of the sensitivity of cephalopod populations to environmental variation could be achieved by taking into account the ontogeny of the organisms. The comparison of most described species advocates for studies linking development and ecology in this particular group.


Assuntos
Comportamento Animal/fisiologia , Cefalópodes/crescimento & desenvolvimento , Cefalópodes/fisiologia , Ecossistema , Estágios do Ciclo de Vida , Animais
9.
Proc Biol Sci ; 280(1759): 20130273, 2013 May 22.
Artigo em Inglês | MEDLINE | ID: mdl-23516246

RESUMO

Despite its charismatic appeal to both scientists and the general public, remarkably little is known about the giant squid Architeuthis, one of the largest of the invertebrates. Although specimens of Architeuthis are becoming more readily available owing to the advancement of deep-sea fishing techniques, considerable controversy exists with regard to topics as varied as their taxonomy, biology and even behaviour. In this study, we have characterized the mitochondrial genome (mitogenome) diversity of 43 Architeuthis samples collected from across the range of the species, in order to use genetic information to provide new and otherwise difficult to obtain insights into the life of this animal. The results show no detectable phylogenetic structure at the mitochondrial level and, furthermore, that the level of nucleotide diversity is exceptionally low. These observations are consistent with the hypotheses that there is only one global species of giant squid, Architeuthis dux (Steenstrup, 1857), and that it is highly vagile, possibly dispersing through both a drifting paralarval stage and migration of larger individuals. Demographic history analyses of the genetic data suggest that there has been a recent population expansion or selective sweep, which may explain the low level of genetic diversity.


Assuntos
Decapodiformes/genética , Variação Genética , Genoma Mitocondrial , Animais , DNA Mitocondrial/genética , DNA Mitocondrial/metabolismo , Decapodiformes/classificação , Feminino , Masculino , Dados de Sequência Molecular , Filogenia , Filogeografia , Reação em Cadeia da Polimerase , Análise de Sequência de DNA , Homologia de Sequência
10.
J Pediatric Infect Dis Soc ; 1(4): 268-77, 2012 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-23687580

RESUMO

BACKGROUND: Rotavirus is the most common cause of infectious diarrhea in children worldwide. Recent studies have described changes in the burden of all-cause gastroenteritis; however, there are limited data on the clinical and economic impact of rotavirus vaccine on cases of laboratory-confirmed rotavirus disease. METHODS: We performed a retrospective study of laboratory-confirmed rotavirus disease from July 2003 through June 2010 at a children's hospital and a community hospital in Utah. Demographics and hospital costs for children <5 years with rotavirus symptoms and a positive rotavirus enzyme immunoassay test on a stool specimen were abstracted from electronic medical records. We compared the prevaccine period (2003-2007) with the postvaccine period (2008-2010). RESULTS: The overall incidence of rotavirus gastroenteritis declined in the postvaccine period, from 26.6 to 5.2 cases per 10 000 person-years for Salt Lake County residents. The largest decrease in the incidence of rotavirus gastroenteritis was among children <12 months (-87%; 95% confidence interval [CI], 79-93). Older children (12-23 months) also experienced significant decreases (-81%; 95% CI, 72-88), as did those 24-59 months (-61%; 95% CI, 51-71). In 2009, 3 years after rotavirus vaccine introduction, there was a 79% decrease in emergency department visits and a 78% decrease in hospitalizations across both hospitals. The cost of emergency department visits and hospitalizations for rotavirus gastroenteritis decreased by 79% and 72%, respectively, resulting in annual savings of $790 000 at a children's hospital and $140 000 at a community hospital. CONCLUSION: Rotavirus vaccination in infants has dramatically decreased the clinical burden and direct medical costs of rotavirus gastroenteritis in both infants and young children.

13.
J Morphol ; 271(2): 143-51, 2010 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-19722250

RESUMO

A morphological comparison of the spermatozoa of the octopods Bathypolypus bairdii and B. sponsalis has been carried out by electron microscopy. Although the mature spermatozoon of B. bairdii is longer and thinner than that of B. sponsalis, its general ultrastructure is similar except for some minor differences. Their characteristic acrosomes, described here for the first time, consist of a periodically banded cone surrounded by a double helix whose arrangement has been defined by a numeric expression. The plasma membrane of sponsalis that surrounds the acrosome has many projections filled with abundant granular cytoplasm, which appears as a star-shaped acrosome in cross-section. The mitochondrial sheath contains 9-11 mitochondria in bairdii but only 9 in sponsalis. A comparison with other Octopodidae shows that the nucleus of both species is the largest ever seen. Our results support the capability of sperm morphology to discriminate between species and could even discern at higher taxonomic levels.


Assuntos
Octopodiformes/ultraestrutura , Espermatozoides/ultraestrutura , Acrossomo/fisiologia , Acrossomo/ultraestrutura , Animais , Axonema/fisiologia , Axonema/ultraestrutura , Membrana Celular/fisiologia , Membrana Celular/ultraestrutura , Núcleo Celular/fisiologia , Núcleo Celular/ultraestrutura , Tamanho do Núcleo Celular/fisiologia , Tamanho Celular , Citoplasma/fisiologia , Citoplasma/ultraestrutura , Citoesqueleto/fisiologia , Citoesqueleto/ultraestrutura , Fertilização/fisiologia , Flagelos/fisiologia , Flagelos/ultraestrutura , Masculino , Microscopia Eletrônica de Varredura , Microscopia Eletrônica de Transmissão , Mitocôndrias/fisiologia , Mitocôndrias/ultraestrutura , Octopodiformes/fisiologia , Especificidade da Espécie , Espermatozoides/fisiologia
14.
Rev Med Inst Mex Seguro Soc ; 48(4): 443-6, 2010.
Artigo em Espanhol | MEDLINE | ID: mdl-21194516

RESUMO

BACKGROUND: To preserve the umbilical cord blood (UCB), the volume containing the cells must be reduced before freezing, but the quality, quantity and functionality of the cells has to be preserved during this procedure. The aim is to compare the performance of two different techniques for volume reduction. METHODS: A semiautomatic system and an automatic system were compared as two different UCB volume reduction techniques. Total nucleated cell (TNC) counts and viability were measured before and after volume reduction. The CD34+ cell counts also were measured. RESULTS: Seventy units of cord blood cells (UCB) were collected. Thirty-three volume reduction procedures were performed by semiautomatic system and thirty-seven by automatic system. The volume recovered and the CD34+ count in both techniques was similar, although the viability differed slightly (1% higher by Optipress II). CONCLUSIONS: The semiautomatic and automatic techniques are suitable to reduce volumes of UCB units.


Assuntos
Preservação de Sangue/métodos , Sangue Fetal , Células Sanguíneas , Humanos
15.
Pediatr Dermatol ; 26(2): 159-61, 2009.
Artigo em Inglês | MEDLINE | ID: mdl-19419462

RESUMO

Approximately one-third of adult patients with dermatomyositis develop malignancy, usually within 1 year of diagnosis of dermatomyositis. This phenomenon is not seen in patients with juvenile dermatomyositis. We are reporting a case of B-cell lymphoma arising from a calcinotic lesion in a 14-year-old girl who had been diagnosed with juvenile dermatomyositis 3 years prior. Our review of the literature revealed only one other case of malignancy arising from an area of calcinosis.


Assuntos
Calcinose/complicações , Dermatomiosite/complicações , Linfoma de Células B/complicações , Síndromes Paraneoplásicas/complicações , Dermatopatias/complicações , Adolescente , Feminino , Humanos
16.
Biol Rev Camb Philos Soc ; 82(2): 257-63, 2007 May.
Artigo em Inglês | MEDLINE | ID: mdl-17437560

RESUMO

We here investigate the relationship between oceanographic processes and variability in parasite recruitment to host populations using existing data from host-parasite systems encountering differing hydrographic conditions. Combined epidemiological data obtained from both exploited fish and cephalopod populations indicate that variability in recruitment of parasite infracommunities tends to be associated with major current systems of the World's oceans. It appears that instability in water masses caused by physical perturbations (e.g. water mass convergence and turbulent mixing in upwelling systems) is associated with instability of trophic interactions over time, which in turn leads to a paucity of parasite communities in that area. The likely relationship between parasite recruitment and oceanographic regime should be extremely useful to the fishing industry and also as an indicator of ecosystem health.


Assuntos
Cefalópodes/parasitologia , Peixes/parasitologia , Interações Hospedeiro-Parasita , Animais , Oceanos e Mares
17.
J Med Genet ; 44(1): 75-80, 2007 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-16825434

RESUMO

BACKGROUND: Mdm2 is a natural inhibitor of p53 function and its overexpression impairs p53 transcriptional activity. T-->G single-nucleotide polymorphism at position 309 (SNP309) of mdm2 induces overexpression of mdm2, but inhibits p53. OBJECTIVES: To determine whether SNP309 is a risk-modifier polymorphism in colorectal cancer (CRC) and whether tumour selection of P53 mutations are influenced by SNP309. METHODS: Single-stranded conformation polymorphism and automatic sequencing were performed. RESULTS: SNP309 is not associated with the risk of CRC or recurrence of tumours. These data do not over-ride the tumour-selection capabilities of P53 mutations in CRC. However, a significant association with non-dominant-negative P53 mutations (p = 0.02) was found. CONCLUSIONS: MDM2-SNP309 favours tumour selection of non-dominant negative P53 mutations in CRC, which also show an earlier age of tumour onset.


Assuntos
Neoplasias Colorretais/genética , Genes p53 , Homozigoto , Proteínas Proto-Oncogênicas c-mdm2/genética , Idade de Início , Idoso , Idoso de 80 Anos ou mais , Estudos de Casos e Controles , Neoplasias Colorretais/epidemiologia , Humanos , Polimorfismo de Nucleotídeo Único , Polimorfismo Conformacional de Fita Simples , Fatores de Risco
18.
Vet J ; 174(1): 206-8, 2007 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-16782369

RESUMO

An eight-year old Rottweiler dog was presented with signs of enophthalmia, ptosis, anisocoria and mydriasis of the right eye, which showed visual disturbance, reduced or absent reflexes, and ophthalmoplegia. Consensual pupillary light reflex was also absent in the left eye. These neurological deficits were compatible with cavernous sinus syndrome. Computed tomography images of the cavernous sinus and the optical fissure revealed a mildly calcified mass arising from the right presphenoid bone extending further caudally into the orbital foramina. This extension of the mass affected the normal function of several cranial nerves. The dog was euthanased within one year of the initial presentation following development of forebrain signs. A chondrosarcoma was diagnosed histologically after necropsy.


Assuntos
Condrossarcoma/veterinária , Doenças do Cão/diagnóstico , Neoplasias Oculares/veterinária , Animais , Seio Cavernoso/patologia , Condrossarcoma/diagnóstico , Condrossarcoma/patologia , Doenças do Cão/patologia , Cães , Neoplasias Oculares/diagnóstico , Neoplasias Oculares/patologia , Evolução Fatal , Feminino , Tomografia Computadorizada por Raios X/veterinária
19.
Bol Asoc Med P R ; 98(4): 304-11, 2006.
Artigo em Inglês | MEDLINE | ID: mdl-19610572

RESUMO

Medical statements from previous epidemiologic studies consider temporal arteritis as extremely rare or absent in Hispanic patients. A probable genetic protective condition was proposed as an explanation for this. We performed a descriptive observational, retrospective, comparable and not randomized study in the southern region of Puerto Rico (Ponce Area). The period for recollection of data was July/2002 to March/2004. We reviewed all the information of the clinical charts of patients diagnosed with temporal arteritis who were seen in the medical offices of one internist and two rheumatologists of the teaching staff of Damas Hospital. The subjects of our study consisted of 11 patients (8 female and 3 male), between the ages of 70 to 90, all of Hispanic origin, with a diagnosis of temporal arteritis. Frequencies and percentages were used to describe the data of the study. Headache was the most common symptom. Other symptoms included the presence of fatigue, malaise, anorexia, scalp tenderness, amaurosis fugax and decreased vision. Laboratory results showed the presence of a mild leukocytosis and anemia in most of the patients. Renal and liver functions were observed to be well-preserved, and serum electrolyte levels were within normal limits. The increase of the ESR and C Reactive Protein values and positive unilateral and bilateral biopsy studies were statistically significant. All of the above characterization of Hispanic population with temporal arteritis cited in our study correlates well with the classic description of the disease in previous epidemiological studies conducted on non-Hispanic subjects. Our study confirmed the presence of temporal arteritis in a Hispanic population. The disease was more prevalent in women than men, with a female to male ratio of 2:6, which is the lowest ratio found for this disease compared to previous epidemiological studies. In our study group, the disease was found in patients over 70 years of age, with a mean age of 75.7. Arterial hypertension was the most commonly associated condition in our patients, probably due to its high prevalence in our community. The clinical characteristics of our patients correlate closely with the previous data from other ethnic groups.


Assuntos
Arterite de Células Gigantes , Hispano-Americanos , Idoso , Idoso de 80 Anos ou mais , Estudos Transversais , Feminino , Arterite de Células Gigantes/diagnóstico , Arterite de Células Gigantes/epidemiologia , Humanos , Masculino , Porto Rico , Estudos Retrospectivos
20.
Rev Gastroenterol Mex ; 67(2): 76-81, 2002.
Artigo em Espanhol | MEDLINE | ID: mdl-12214338

RESUMO

OBJECTIVE: To report our results with surgical procedures for treatment of iatrogenic injuries of bile duct. SETTING: Tertiary-level health care hospital. DESIGN: Retrospective, observational, and descriptive study. MATERIAL AND METHOD: We studied all patients operated on due to iatrogenic of injuries of the bile duct over the last 21 years (1980-2001). We analyzed the following variables: age; gender; previous bile duct surgical procedure; auxiliary diagnosis; type of bile duct injury according to Bismuth's classification; surgical procedure used; non-related mortality, and postoperative morbimortality. RESULTS: Fifty four patients were operated on (46 female, eight male) ranging from 19 to 71 years of age; 39 were sent to the hospital, 15 were injured at the hospital in 7,098 gallbladder and bile duct procedures (0.21%), 83.3% in open cholecystectomy, and 16.6% in laparoscopic cholecystectomy. In 86% of cases, diagnosis was made by percutaneous cholangiography and injuries types were: I = 13%, II = 26%, III = 50%, IV = 9.2%, and V = 1.8%. Roux-en-Y intrahepaticojejunostomy was the most common procedure (51.9%) followed by hepaticojejunostomy (37%). Of 54 surgical patients, five died due to situations unrelated to bile duct illness, and they were cared for more than one year without complications; 46 patients (85.2%) did not show strictures, three patients (5.5%) were reoperated on because of strictures, all without recurrent strictures for more than one year of care, with a total of good results of 90.7%; mortality: four patients (7.2%), and complications after procedure: 11%. Strictures were developed during the first year after surgical procedure. CONCLUSION: Our results are similar to others found in researches from Mexico and other countries; therefore, we recommend long-term care of patients.


Assuntos
Ductos Biliares/lesões , Ductos Biliares/cirurgia , Adolescente , Adulto , Idoso , Criança , Colecistectomia , Colecistectomia Laparoscópica , Feminino , Seguimentos , Humanos , Doença Iatrogênica , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias , Reoperação , Estudos Retrospectivos , Fatores de Tempo
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