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Emerg Microbes Infect ; 10(1): 2199-2201, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34749583


We report pilot studies to evaluate the susceptibility of common domestic livestock (cattle, sheep, goat, alpaca, rabbit, and horse) to intranasal infection with SARS-CoV-2. None of the infected animals shed infectious virus via nasal, oral, or faecal routes, although viral RNA was detected in several animals. Further, neutralizing antibody titres were low or non-existent one month following infection. These results suggest that domestic livestock are unlikely to contribute to SARS-CoV-2 epidemiology.

COVID-19/veterinária , Especificidade de Hospedeiro , Gado/virologia , SARS-CoV-2/patogenicidade , Animais , Anticorpos Neutralizantes/sangue , Anticorpos Neutralizantes/imunologia , Anticorpos Antivirais/sangue , Anticorpos Antivirais/imunologia , COVID-19/imunologia , COVID-19/virologia , Camelídeos Americanos/virologia , Bovinos/virologia , Chlorocebus aethiops , Reservatórios de Doenças/virologia , Cabras/virologia , Cavalos/virologia , Especificidade de Hospedeiro/imunologia , Humanos , Cavidade Nasal/virologia , RNA Viral/análise , Coelhos/virologia , Reto/virologia , Sistema Respiratório/virologia , SARS-CoV-2/genética , SARS-CoV-2/isolamento & purificação , Ovinos/virologia , Especificidade da Espécie , Células Vero , Eliminação de Partículas Virais , Vísceras/virologia
Emerg Infect Dis ; 27(8): 2073-2080, 2021 08.
Artigo em Inglês | MEDLINE | ID: mdl-34286685


Wild animals have been implicated as the origin of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but it is largely unknown how the virus affects most wildlife species and if wildlife could ultimately serve as a reservoir for maintaining the virus outside the human population. We show that several common peridomestic species, including deer mice, bushy-tailed woodrats, and striped skunks, are susceptible to infection and can shed the virus in respiratory secretions. In contrast, we demonstrate that cottontail rabbits, fox squirrels, Wyoming ground squirrels, black-tailed prairie dogs, house mice, and racoons are not susceptible to SARS-CoV-2 infection. Our results expand the knowledge base of susceptible species and provide evidence that human-wildlife interactions could result in continued transmission of SARS-CoV-2.

COVID-19 , SARS-CoV-2 , Animais , Animais Selvagens , Suscetibilidade a Doenças , Humanos , Mamíferos , Camundongos